                         SEQUENCE LISTING

<110>  The University of Florida Research Foundation, Inc.
 
<120>  GENE THERAPY FOR COCKAYNE SYNDROME

<130>  32917/54026

<150>  US 62/992,729
<151>  2020-03-20

<160>  17    

<170>  PatentIn version 3.5

<210>  1
<211>  2011
<212>  DNA
<213>  Homo Sapiens

<300>
<308>  GENBANK / U28413.1
<309>  1995-12-02
<313>  (1)..(2011)

<400>  1
cgacgtccag tgctccagcc ggtgtgagga cacgatatgc tggggttttt gtccgcacgc       60

caaacgggtt tggaggaccc tcttcgcctt cggagagcag agtcaacacg gagagttttg      120

ggactggaat taaataaaga cagagatgtt gaaagaatcc acggcggtgg aattaacacc      180

cttgacattg aacctgttga agggagatac atgttatcag gtggttcaga tggtgtgatt      240

gtactttatg accttgagaa ctccagcaga caatcttatt acacatgtaa agcagtgtgt      300

tccattggca gagatcatcc tgatgttcac agatacagtg tggagactgt acagtggtat      360

cctcatgaca ctggcatgtt cacatcaagc tcatttgata aaactctgaa agtatgggat      420

acaaatacat tacaaactgc agatgtattt aattttgagg aaacagttta tagtcatcat      480

atgtctccag tctccaccaa gcactgtttg gtagcagttg gtactagagg acccaaagta      540

caactttgtg acttgaagtc tggatcctgt tctcacattc tacagggtca cagacaagaa      600

atattagcag tttcctggtc tccacgttat gactatatct tggcaacagc aagtgctgac      660

agtagagtaa aattatggga tgtgagaaga gcatcaggat gtttgattac tcttgatcaa      720

cataatggga aaaagtcaca agctgttgaa tcagcaaaca ctgctcataa tgggaaagtt      780

aatggcttat gttttacaag tgatggactt cacctcctca ctgttggtac agataatcga      840

atgaggctct ggaatagttc caatggagaa aacacacttg tgaactatgg aaaagtttgt      900

aataacagta aaaaaggatt gaaattcact gtctcctgtg gctgcagttc agaatttgtt      960

tttgtaccat atggtagcac cattgctgtt tatacagttt actcaggaga acagataact     1020

atgcttaagg gacattataa aactgttgac tgctgtgtat ttcagtcaaa tttccaggaa     1080

ctttatagtg gtagcagaga ctgcaacatt ctggcttggg ttccatcctt atatgaacca     1140

gttcctgatg atgatgagac tacaacaaaa tcacaattaa atccggcctt tgaagatgcc     1200

tggagcagca gtgatgaaga aggatgaata tcatctttag tacctttttg tctctgctga     1260

aactttttaa atgagactgt gtttttttca actgtatggt ctattcctga cagctaaatt     1320

agccctaaat gcgggtaata tttttcctca tgttttaaaa tgaggttaat atttgcataa     1380

aatcctaaaa cagacttctg tatagtttat ttagtcaaaa tgtgttcctt gatcccagat     1440

gttgtggcct gggaaagccc tcattgctac agtacaagta acacaagtcg ttgtacctca     1500

gttgtgacct tcagcagatt ttatgaacta taagatgcag tctcagagga tcagcaagtg     1560

gaggccatca gtattgactt tctcttactt gctgtactat cagcctgctc gtttccacct     1620

ttaagaatga ttttgccaag aatgattata tcaaaaatag tagttgaaat ggtaacatca     1680

aaattatttt attctttctt cttcatgtat tcacattttt cagtggtttc atttaattaa     1740

ccatgcttta tgttaaacat tttggggctc aatgtctcct actatccaaa atgtgcatca     1800

caggaggctc ttaactttgt gaaaatccca tgtttgcttt attttatttt aatgtcagaa     1860

ggcagtttgc gctaatgctt gaactctttt tctgtgaaac tcattaaggt atgaccaaat     1920

cctgcctcat taattcaagc agaaaatatc ctggcaggga atctggctta aacatgaaat     1980

gctgtaataa aatttctatg ttattgtctc a                                    2011


<210>  2
<211>  4714
<212>  DNA
<213>  Homo Sapiens

<300>
<308>  Genbank / L04791.1
<309>  1994-11-08
<313>  (1)..(4714)

<400>  2
tgggttccaa ggcggctggc ggcggtagcg tctctgtttc cttgtgggcg ctcgcgcggc       60

cctgggtagt ctgtagagaa tgccaaatga gggaatcccc cactcaagtc aaactcagga      120

gcaagactgt ttacagagtc aacctgtcag taataatgaa gaaatggcaa tcaagcaaga      180

aagtggtggt gatggggagg tggaggagta cctgtccttt cgttctgtgg gtgacgggct      240

gtccacctct gctgtggggt gcgcatcagc agctccgagg agagggccag ccctgctgca      300

catcgaccga catcagatcc aggcagtaga gcctagcgcc caggcccttg agctgcaggg      360

tttgggtgtg gacgtctatg accaggacgt gctggaacag ggagtgcttc agcaggtgga      420

caatgccatc catgaggcca gccgtgcctc ccagctcgtt gacgtggaga aggagtatcg      480

gtcggtcctg gatgacctca cgtcatgtac gacatcccta aggcaaatca ataaaattat      540

tgaacagctt agccctcaag ctgccaccag cagagacatc aacaggaaac tagattctgt      600

aaaacgacag aagtataata aggaacaaca gctaaaaaag atcactgcaa aacaaaagca      660

tctccaggcc atccttggag gagcagaggt gaaaattgaa ctagatcacg ccagtctgga      720

ggaggatgca gagccggggc catccagtct tggcagcatg ctcatgcctg tccaggagac      780

tgcctgggaa gagctcatcc gcactggcca gatgacacct tttggtaccc agatccctca      840

gaaacaggag aaaaagccca gaaaaatcat gcttaatgaa gcatcaggct tcgaaaagta      900

tttggcagat caagcaaaac tgtcttttga aaggaagaag caaggttgta ataaaagagc      960

agctagaaaa gctccagccc cagtcacgcc tccagcccca gtgcaaaata aaaacaaacc     1020

aaacaagaaa gccagagttc tgtccaaaaa agaggagcgt ttgaaaaagc acatcaagaa     1080

actccagaag agggctttgc agttccaggg gaaagtggga ttgccaaagg caaggagacc     1140

ttgggagtca gacatgaggc cagaggcaga gggagactct gagggtgaag agtctgagta     1200

tttccccaca gaggaggagg aagaggagga agatgacgag gtggaggggg cagaggcgga     1260

cctgtctgga gatggtactg actatgagct gaagcctctg cccaagggcg ggaaacggca     1320

gaagaaagtg ccagtgcagg agattgatga tgactttttc ccaagttctg gggaagaagc     1380

tgaagctgct tctgtaggag aaggaggagg aggaggtcgg aaagtgggaa gataccgaga     1440

tgatggagat gaagattatt ataagcagcg gttaaggaga tggaataaac tgagactgca     1500

ggacaaagag aaacgtctga agctggagga cgattctgag gaaagtgatg ctgaatttga     1560

cgaaggtttt aaagtgccag gttttctgtt caaaaagctt tttaagtacc agcagacagg     1620

tgttaggtgg ctgtgggaat tgcactgcca gcaggcagga ggaattctgg gagatgaaat     1680

gggattgggc aagaccatcc agataattgc cttcttggca ggtctgagct acagcaagat     1740

caggactcgt ggttcaaatt acaggtttga ggggttgggt ccaactgtaa ttgtctgtcc     1800

aacaacagtg atgcatcagt gggtgaagga atttcacacg tggtggcctc cgttcagagt     1860

ggcaattcta catgaaaccg gttcctatac ccacaaaaag gagaaactaa ttcgagatgt     1920

tgctcattgt catggaattt tgatcacatc ttactcctac attcgattga tgcaggatga     1980

cattagcagg tatgactggc actatgtgat cttggacgaa ggacacaaaa ttcgaaatcc     2040

aaatgctgct gtcacccttg cttgcaaaca gtttcgcacc cctcatcgga tcattctgtc     2100

tggctcaccg atgcaaaata acctccgaga gctgtggtcg ctctttgact tcatcttccc     2160

gggaaagtta ggcacgttgc ctgtgtttat ggagcagttc tccgtcccca tcaccatggg     2220

gggatattca aatgcttccc cagtacaggt caaaactgct tacaagtgtg catgtgtctt     2280

acgagatacc ataaatccat acctactgcg gagaatgaag tcagatgtca agatgagcct     2340

ttctttgcca gataaaaatg aacaggtctt attttgccgt cttacagatg agcagcataa     2400

agtctaccaa aatttcgttg attccaaaga agtttacagg attctcaatg gagagatgca     2460

gattttctcc ggacttatag ccctaagaaa aatttgcaac caccctgatc tcttttctgg     2520

aggtcccaag aatctcaaag gtcttcctga tgatgaacta gaagaagatc agtttgggta     2580

ctggaaacgt tctgggaaaa tgattgttgt tgagtctttg ttgaaaatat ggcacaagca     2640

gggtcagcga gtattgctgt tttctcagtc aaggcagatg ctggacatac ttgaagtatt     2700

ccttagagcc caaaagtata cctatctcaa gatggatggt accactacaa tagcttcaag     2760

acagccactg attacgagat acaatgagga cacatccata tttgtgtttc ttctgaccac     2820

gcgggtgggc ggcttaggtg tcaacctgac gggggcaaac agagttgtca tctatgaccc     2880

agactggaac ccaagcacgg acacgcaggc ccgggagcga gcatggagaa taggccagaa     2940

gaagcaagtg actgtgtaca ggctcctgac tgcgggcacc attgaagaaa agatctacca     3000

ccgacaaatc ttcaagcagt ttttgacaaa tagagtgcta aaagacccaa aacaaaggcg     3060

gtttttcaaa tccaatgatc tctatgagct atttactctg actagtcctg atgcatccca     3120

gagcactgaa acaagtgcaa tttttgcagg aactggatca gatgttcaga cacccaaatg     3180

ccatctaaaa agaaggattc aaccagcctt tggagcagac catgatgttc caaaacgcaa     3240

gaagttccct gcttctaaca tatctgtaaa tgatgccaca tcatctgaag agaaatctga     3300

ggctaaagga gctgaagtaa atgcagtaac ttctaatcga agtgatcctt tgaaagatga     3360

ccctcacatg agtagtaatg taactagcaa tgataggctt ggagaagaga caaatgcagt     3420

atctggacca gaagagttgt cagtgattag tggaaatggg gaatgttcaa attcttcagg     3480

aacaggcaaa acttctatgc catctggtga tgaaagcatt gatgaaaagt taggtctttc     3540

ttacaaaaga gaaagaccca gccaggctca aacagaagct ttttgggaga ataaacaaat     3600

ggaaaataat ttttataagc acaagtcaaa aacaaaacat catagtgtgg cagaagaaga     3660

gaccctggag aaacatctga gaccaaagca aaagcctaag aactctaagc attgcagaga     3720

cgccaagttt gaaggaactc gaattccaca cctggtgaag aaaaggcgtt accagaagca     3780

agacagtgaa aacaagagtg aggccaagga acagagcaat gacgattatg ttttggaaaa     3840

gcttttcaaa aaatcagttg gcgtgcacag tgtcatgaag cacgatgcca tcatggatgg     3900

agccagccca gattatgtac tggtggaggc agaagccaac cgagtggccc aggatgccct     3960

gaaagcactg aggctctctc gtcagcggtg tctgggagca gtgtctggtg ttcccacctg     4020

gactggccac agggggattt ctggtgcacc agcaggaaaa aagagtagat ttggtaagaa     4080

aaggaattct aacttctctg tgcagcatcc ttcatcaaca tctccaacag agaagtgcca     4140

ggatggcatc atgaaaaagg agggaaaaga taatgtccct gagcatttta gtggaagagc     4200

agaagatgca gactcttcat ccgggcccct cgcttcctcc tcactcttgg ctaaaatgag     4260

agctagaaac cacctgattc tgccagagcg tttagaaagt gaaagcgggc acctgcagga     4320

agcttctgcc ctgctgccca ccacagaaca cgatgacctt ctggtggaga tgagaaactt     4380

catcgctttc caggcccaca ctgatggcca ggccagcacc agggagatac tgcaggagtt     4440

tgaatccaag ttatctgcat cacagtcttg tgtcttccga gaactattga gaaatctgtg     4500

cactttccat agaacttctg gtggtgaagg aatttggaaa ctcaagccag aatactgcta     4560

aacaacattg cttcctaaac tttcaagtcc ctttttctaa cgggcatttc tgattattaa     4620

tttattatta ataatcatgt ttgtcaatgg aagttggctg cacttgatgt ttgtttgcat     4680

gatgtctacc tcagaattaa aactttaagg aagg                                 4714


<210>  3
<211>  3660
<212>  DNA
<213>  Homo Sapiens

<300>
<308>  Genbank / D16305.1
<309>  2008-09-26
<313>  (1)..(3660)

<400>  3
cacccccttc atgggggtcc agggcctctg gaagctgctg gagtgctccg ggcggcaggt       60

cagccccgaa gcgctggaag ggaagatcct ggctgttgat attagcattt ggttaaacca      120

agcacttaaa ggagtccggg atcgccatgg gaactcaata gaaaatcctc atcctctcac      180

tttgtttcat cggctctgca aactcttatt ttttcgaatt cgtcctattt ttgtgtttga      240

tggggatgct ccactattga agaaacagac tttggtgaag agaaggcaga gaaaggactt      300

agcgtccagt gactccagga aaacgacaga gaagcttctg aaaacatttt tgaaaagaca      360

agccatccaa acttccttca gaagccaaag agatgaagca ctacccagtc ttacccaagt      420

tcgaagagaa aacgacctct atgttttgcc tcctttacaa gaggaagaaa aacacagttc      480

agaagaggaa gatgaaaaag aatggcaaga aagaatgaat caaaaacaag cattacagga      540

agagttcttt cataatcctc aagcgataga tattgagtct gaggacttca gcagcctgcc      600

ccctgaagta aagcatgaaa tcttgactga tatgaaagag ttcaccaagc gcagaagaac      660

attatttgaa gcaatgccag aggagtctga tgacttttca cagtaccaac tcaaaggctt      720

gcttaaaaag aactatctga accagcatat agaacatgtc caaaaggaag tgaatcagca      780

acattcagga cacatccgaa gcagtcatga agatgaaggg ggctttctga aggaggtaga      840

gtcaaggaga gtggtctctg aagacacttc acattacatc ttgataaaag gtattcaagc      900

taagacagtt gcagaagtgg attcagagtc tcttccttct tccagcaaaa tgcacggcat      960

gtcttttgac gtgaagtcat ctccatgtga aaaactgaag acagagaaag agcctgatgc     1020

tacccctcct tctccaagaa ctttactagc tatgcaagct gccctgctgg gaagtagctc     1080

agaagaggag ctggagagtg aaaatcgaag gcaggcccgt gggaggaacg cacctgctgc     1140

tgtagacgaa ggctccatat caccccggac tctttcagcc attaagagag ctcttgacga     1200

tgacgaagat gtaaaagtgt gtgctgggga tgatgtgcag acgggagggc caggagcaga     1260

agaaatgcgt ataaacagct ccaccgagaa cagtgatgaa ggacttaaag tgagagatgg     1320

aaaaggaata ccgtttactg caacacttgc gtcatctagt gtgaactctg cagaggagca     1380

cgtagccagc actaatgagg ggagagagcc cacagactca gttccaaaag aacaaatgtc     1440

acttgttcac gtggggactg aagcctttcc gataagtgat gagtctatga ttaaggacag     1500

aaaagatcgg ctgcctctgg agagtgcagt ggttagacat agtgacgcac ctgggctccc     1560

gaatggaagg gaactgacac cggcatctcc aacttgtaca aattctgtgt caaagaatga     1620

aacacatgct gaagtgcttg agcagcagaa cgaactttgc ccatatgaga gtaaattcga     1680

ttcttctctt ctttcaagtg atgatgaaac aaaatgtaaa ccgaattctg cttctgaagt     1740

cattggccct gtcagtttgc aagaaacaag tagcatagta agtgtccctt cagaggcagt     1800

agataatgtg gaaaatgtgg tgtcatttaa tgctaaagag catgagaatt ttctggaaac     1860

catccaagaa cagcagacca ctgaatctgc aggccaggat ttaatttcca ttccaaaggc     1920

cgtggaacca atggaaattg actcggaaga aagtgaatct gatggaagtt tcattgaagt     1980

gcaaagtgtg attagtgatg aggaacttca agcagaattc cctgaaactt ccaaacctcc     2040

ctcagaacaa ggcgaagagg aactggtagg aactagggag ggagaagccc ctgctgagtc     2100

cgagagcctc ctgagggaca actctgagag ggacgacgtg gatggtgagc cacaggaagc     2160

tgagaaagat gcggaagatt cgctccatga atggcaagat attaatttgg aggagttgga     2220

aactctggag agcaacctct tagcacagca gaattcactg aaagctcaaa aacagcagca     2280

agaacggttc gctgctactg tcaccggaca gatgttcctg gaaagccagg aactcctgcg     2340

cctgttcggc attccctaca tccaggctcc catggaagca gaggcgcagt gcgcagtcct     2400

ggacctgact gatcagactt ccggaaccat cactgatgac agtgatatct ggctgtttgg     2460

agcgcggcat gtctatagaa acttttttaa taaaaacaag tttgtagaat attatcaata     2520

tgtggacttt cacaatcaat tgggattgga ccggaataag ttaataaatt tggcttattt     2580

gcttggaagt gattataccg ggaataccaa ctgtgggttg tgtaccgcca tggaaattct     2640

caatgaattc cctgggcatg gcctggaacc tctcctaaaa ttctcagaat ggtggcatga     2700

agctcaaaaa aatccaaaga taagacctaa tcctcatgac accaaagtga aaaaaaaatt     2760

acggacattg caactcaccc ctggctttcc taacccagct gttgccgagg cctacctcaa     2820

acccgtggtg gatgactcga agggatcctt tctgtggggg aaacctgatc tcgacaaaat     2880

tagcgaattt tgtcagcggt atttcggctg gaacagaacg aagacagatg aatctctgtt     2940

tcctgtatta aagcaactcg atgcccagca gacacagctc cgaattgatt ccttctttag     3000

attagcacaa caggagaaag aagatgctaa acgtattaag agccagagac taaacagagc     3060

tgtgacatgt atgctaagga aagagaaaga agcagcagcc agcgaaatag aagcagtttc     3120

tgttgccatg gagaaagaat ttgagctact tgataaggca aaacgaaaaa cccagaagag     3180

aggcataaca aataccttag aagagtcatc aagcctgaaa agaaagaggc tttcagattc     3240

taaacgaaag aatacatgcg gtggattttt gggggagacc tgcctctcag aatcatctga     3300

tggatcttca agtgaagatg ctgaaagttc atctttaatg aatgtacaaa ggagaacagc     3360

tgcgaaagag ccaaaaacca gtgcttcaga ttcgcagaac tcagtgaagg aagctcccgt     3420

gaagaatgga ggtgcgacca ccagcagctc tagtgatagt gatgacgatg gagggaaaga     3480

gaagatggtc ctcgtgaccg ccagatctgt gtttgggaag aaaagaagga aactaagacg     3540

tgcgagggga agaaaaagga aaacctaatt aaaaaatatg tatcctctat aattagttat     3600

gacagccatt tgtaatgaat ttgtgtgaaa gacgtaataa aattaactgg tagcacggtc     3660


<210>  4
<211>  6
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer

<400>  4
aataaa                                                                   6


<210>  5
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  5
acaacattgc ttcctaaact ttcaagtccc                                        30


<210>  6
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  6
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtgg                     106


<210>  7
<211>  581
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  7
ttaatagtaa tcaattacgg ggtcattagt tcatagccca tatatggagt tccgcgttac       60

ataacttacg gtaaatggcc cgcctggctg accgcccaac gacccccgcc cattgacgtc      120

aataatgacg tatgttccca tagtaacgcc aatagggact ttccattgac gtcaatgggt      180

ggagtattta cggtaaactg cccacttggc agtacatcaa gtgtatcata tgccaagtcc      240

gccccctatt gacgtcaatg acggtaaatg gcccgcctgg cattatgccc agtacatgac      300

cttacgggac tttcctactt ggcagtacat ctacgtatta gtcatcgcta ttaccatggt      360

gatgcggttt tggcagtaca ccaatgggcg tggatagcgg tttgactcac ggggatttcc      420

aagtctccac cccattgacg tcaatgggag tttgttttgg caccaaaatc aacgggactt      480

tccaaaatgt cgtaataacc ccgccccgtt gacgcaaatg ggcggtaggc gtgtacggtg      540

ggaggtctat ataagcagag ctcgtttagt gaaccgtcag a                          581


<210>  8
<211>  1974
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  8
atgctgggct ttctgagcgc cagacagacc ggcctggaag atcccctgag actgagaagg       60

gccgagagca ccagaagagt gctgggcctg gaactgaaca aggaccggga cgtggaacgg      120

atccacggcg gaggcatcaa caccctggac atcgagcctg tggaaggccg gtacatgctg      180

agcggcggat ccgatggcgt gatcgtgctg tacgacctgg aaaacagcag ccggcagagc      240

tactacacat gcaaggccgt gtgcagcatc ggcagggacc accccgatgt gcaccggtac      300

agcgtggaaa ccgtgcagtg gtatccccac gacaccggca tgttcaccag cagcagcttc      360

gacaagaccc tgaaagtgtg ggacaccaat accctgcaga ccgccgacgt gttcaacttc      420

gaggaaacag tgtacagcca ccacatgagc cccgtgtcca ccaagcactg tctggtggcc      480

gtgggcacca gaggccctaa ggtgcagctg tgcgatctga agtccggcag ctgcagccac      540

atcctgcagg gccacagaca ggaaatcctg gccgtgtcct ggtcccccag atacgactac      600

atcctggcca ccgccagcgc cgacagcaga gtgaaactgt gggatgtgcg gagagccagc      660

ggctgcctga tcaccctgga tcagcacaac ggcaagaaaa gccaggccgt ggaaagcgcc      720

aacaccgccc acaatggcaa agtgaacggc ctgtgcttca ccagcgacgg cctgcatctg      780

ctgacagtgg gcaccgacaa ccggatgcgg ctgtggaaca gctccaacgg cgagaatacc      840

ctcgtgaact acggcaaagt gtgcaacaac agcaagaagg gcctgaagtt caccgtgtct      900

tgcggctgca gcagcgagtt cgtgttcgtg ccctacggca gcacaatcgc cgtgtacacc      960

gtgtactccg gcgagcagat cacaatgctg aagggccact acaagaccgt ggactgctgc     1020

gtgttccaga gcaacttcca ggaactgtac agcggcagcc gggactgcaa tatcctggcc     1080

tgggtgccca gcctgtacga gcccgtgcct gacgacgatg agacaaccac caagagccag     1140

ctgaaccccg ccttcgagga tgcctggtcc agctccgatg aggaaggctg aatatcatct     1200

ttagtacctt tttgtctctg ctgaaacttt ttaaatgaga ctgtgttttt ttcaactgta     1260

tggtctattc ctgacagcta aattagccct aaatgtgggt aatatttttc ctcatgtttt     1320

aaaatgaggt taatatttgc ataaaatcct aaaacagact tctgtatagt ttatttagtc     1380

aaaatgtgtt ccttgatccc agatgttgtg gcctgggaaa gccctcattg ctacagtaca     1440

agtaacacaa gtcgttgtac ctcagttgtg accttcagca gattttatga actataagat     1500

gcagtctcag aggatcagca agtggaggcc atcagtattg actttctctt acttgctgta     1560

ctatcagcct gctcgtttcc acctttaaga atgattttgc caagaatgat tatatcaaaa     1620

atagtagttg aaatggtaac atcaaaatta ttttattctt tcttcttcat gtattcacat     1680

ttttcagtgg tttcatttaa ttaaccatgc tttatgttaa acattttggg gctcaatgtc     1740

tcctactatc caaaatgtgc atcacaggag gcttttaact ttgtgaaaat cccatgtttg     1800

ctttatttta ttttaatgtc agaaggcagt ttgcgctaat gcttgaactc tttttctgtg     1860

aaactcatta aggtatgacc aaatcctgcc tcattaattc aagcagaaaa tatcctggca     1920

gggaatctgg cttaaacatg aaatgctgta ataaaatttc tatgttattg tctc           1974


<210>  9
<211>  145
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucelotide

<400>  9
aggaacccct agtgatggag ttggccactc cctctctgcg cgctcgctcg ctcactgagg       60

ccgcccgggc aaagcccggg cgtcgggcga cctttggtcg cccggcctca gtgagcgagc      120

gagcgcgcag agagggagtg gccaa                                            145


<210>  10
<211>  147
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  10
ggttggccac tccctctctg cgcgctcgct cgctcactga ggccgggcga ccaaaggtcg       60

cccgacgccc gggctttgcc cgggcggcct cagtgagcga gcgagcgcgc agagagggag      120

tggccaactc catcactagg ggttcct                                          147


<210>  11
<211>  595
<212>  DNA
<213>  Artificial Seuqence

<220>
<223>  Synthetic Polynucleotide

<400>  11
attcggtacc cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc       60

cccgcccatt gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc      120

attgacgtca atgggtggag tatttacggt aaactgccca cttggcagta catcaagtgt      180

atcatatgcc aagtacgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt      240

atgcccagta catgacctta tgggactttc ctacttggca gtacatctac gtattagtca      300

tcgctattac catggtgatg cggttttggc agtacatcaa tgggcgtgga tagcggtttg      360

actcacgggg atttccaagt ctccacccca ttgacgtcaa tgggagtttg ttttggcacc      420

aaaatcaacg ggactttcca aaatgtcgta acaactccgc cccattgacg caaatgggcg      480

gtaggcgtgt acggtgggag gtctatataa gcagagctcg tttagtgaac cgtcagatcg      540

cctggagacg ccatccacgc tgttttgacc tccatagaag acaccgggac cgatc           595


<210>  12
<211>  3696
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  12
atgttgcctt tacttctagg cctgtacgga agtgttactt ctgctctaaa agctgcggaa       60

ttgtacccgc ggccgccgat gggagtacag ggactctgga aactgctgga atgcagtggg      120

agacaagtga gtccggaagc actggaaggt aagattctgg ctgtcgatat ctctatctgg      180

ctcaatcagg ccctgaaagg ggtcagggat agacatggta actccatcga aaatccccac      240

ccgcttaccc tttttcaccg cctgtgcaag cttctgttct tcagaatcag accaatcttc      300

gtgtttgacg gtgacgcacc cctgctgaag aagcaaacac tcgtaaaaag gcgacaacgg      360

aaggatctgg cgagctctga ctcccggaag accacagaga agttgctcaa gacattcctt      420

aagaggcagg ccattcaaac tagtttccgc tcccaacgcg atgaagccct gccttctttg      480

acacaagtga gaagagagaa tgacctgtac gtcctgccac cgctccagga ggaagagaaa      540

cattcttcag aggaggaaga tgaaaaggag tggcaggagc gaatgaatca gaaacaagcc      600

ctgcaggaag aattttttca caacccccag gccatcgaca tcgaatccga ggactttagc      660

tccctcccgc ccgaagtcaa acacgaaatc ctcacagaca tgaaagaatt taccaagcgc      720

cgaagaacct tgtttgaagc catgccagaa gagtccgatg atttcagcca atatcaactt      780

aagggactct tgaaaaagaa ttatttgaac cagcatatag agcatgttca gaaggaggtc      840

aatcagcagc acagcggaca tatccgatcc agccatgaag atgaaggcgg gttccttaag      900

gaagtggaat cccgaagggt cgtatcagaa gacacttctc attacatact gatcaaaggt      960

attcaggcaa aaacggtcgc agaagtggat tccgaaagtc tcccaagcag ctcaaaaatg     1020

catggaatgt cattcgatgt gaagtcaagt ccatgtgaga aactgaaaac agagaaagaa     1080

ccagatgcta caccccccag ccctcgaact ctcttggcga tgcaggcggc cctccttggt     1140

tcctcaagcg aagaggaatt ggagtcagag aaccggagac aggcacgcgg tcggaacgca     1200

cccgcagccg ttgacgaagg atccattagc ccccgcaccc ttagcgccat caaacgggcc     1260

ctcgatgacg acgaggacgt gaaagtatgt gctggagacg acgttcagac tggagggccg     1320

ggggccgaag agatgagaat taacagcagc acagagaata gcgatgaagg cctcaaagtg     1380

agggatggta aagggattcc atttacagcg actctggcgt ccagcagcgt gaattccgca     1440

gaagagcatg tcgcatcaac aaatgaaggc cgcgaaccca cagacagtgt gccgaaggag     1500

caaatgtcac ttgtccacgt cggaactgaa gcctttccaa tcagcgacga atcaatgata     1560

aaagatcgca aagacaggct gcccctcgaa tccgccgtag tgaggcactc cgacgctccg     1620

gggcttccca atggtagaga gcttactcca gcaagcccaa cctgtactaa ttcagtttct     1680

aaaaacgaga ctcatgcaga agtgctcgag cagcagaacg agctttgccc atatgaaagt     1740

aaatttgata gttcactcct ttcttctgac gacgagacaa agtgtaagcc aaattccgca     1800

tctgaagtga taggccctgt atccctccag gaaacctcaa gcatagtgtc cgttccatct     1860

gaagcggttg acaacgtaga gaatgtggtt tcattcaacg caaaagaaca cgagaacttc     1920

ctcgagacca ttcaggagca gcaaacaact gagtctgccg gccaggatct gattagcata     1980

ccaaaagccg tcgaaccaat ggagatcgac agcgaggagt ctgaatccga tgggagcttc     2040

atcgaagtgc agagcgtgat tagcgacgag gaactgcagg cagaattccc ggaaaccagc     2100

aaaccaccga gcgaacaggg tgaggaggaa cttgtcggta cgagggaagg tgaggctcct     2160

gccgagagtg agagcctgct tagggataat agcgagaggg acgacgtcga tggagagccc     2220

caggaagccg agaaggacgc tgaagattct ctccacgaat ggcaggacat taatctggag     2280

gagctggaaa ccttggaaag caatctgctt gcccaacaaa actcactcaa ggcgcagaaa     2340

caacagcagg aacgctttgc agccaccgtt accggacaga tgtttctcga atctcaagag     2400

ttgcttcgcc tgttcggcat cccttacatc caagcaccta tggaggctga agcccaatgt     2460

gcagtgctgg acctcacaga tcagactagc gggacaatca cggatgattc agatatctgg     2520

ctctttggcg ctagacacgt ctaccgcaat tttttcaaca agaataagtt cgtcgagtat     2580

tatcagtatg tggacttcca taaccagctg ggactcgacc gcaataaact gatcaatttg     2640

gcgtaccttc tggggagcga ctacacaggg aacaccaatt gcggcctgtg cacagcaatg     2700

gaaattttga acgaattccc cggccacggt ctggagccgc tcctgaaatt tagcgagtgg     2760

tggcacgaag ctcagaagaa tcctaagatt agaccaaacc cgcatgacac caaggtcaaa     2820

aaaaagctta ggacactgca gctcacaccc gggttcccga atcccgcggt tgcagaagct     2880

tacctcaagc cagtcgttga cgattccaag ggtagcttct tgtggggaaa accggatctt     2940

gataaaatct ccgagttctg tcagagatat tttggttgga atagaactaa gaccgacgag     3000

tctcttttcc ctgttctgaa acaactggat gcacagcaga cacaactgag aatcgattcc     3060

tttttccgcc tggctcaaca ggaaaaagaa gacgccaagc gcataaagag ccaacgcctg     3120

aaccgggcag tgacctgcat gctgagaaaa gaaaaggaag cagcagcaag tgagattgaa     3180

gccgtgagtg tcgctatgga gaaagaattt gagctcctgg ataaggctaa aagaaaaacc     3240

caaaaaagag ggattactaa tacccttgaa gagtcatcta gcttgaagcg aaaaagattg     3300

tccgattcca agcgcaagaa cacgtgcgga ggatttctcg gcgaaacgtg ccttagcgaa     3360

tcctccgacg ggtcaagttc agaggacgcc gaatcttctt ctttgatgaa tgtgcaaaga     3420

agaactgccg ccaaagagcc caagacatct gcaagtgaca gccagaacag cgttaaggaa     3480

gctccagtta aaaatggcgg cgccacaaca tcaagctctt ccgactccga cgacgatggt     3540

ggaaaagaaa agatggtact cgtgacagct cggtctgttt ttggtaagaa aagaagaaag     3600

cttcggaggg ctagaggtcg gaaaagaaaa accggggatc cagacatgat aagatacatt     3660

gatgagtttg gacaaaccac aactagaatg cagtga                               3696


<210>  13
<211>  146
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  13
aggaacccct agtgatggag ttggccactc cctctctgcg cgctcgctcg ctcactgagg       60

ccgcccgggc aaagcccggg cgtcgggcga cctttggtcg cccggcctca gtgagcgagc      120

gagcgcgcag agagggagtg gccaac                                           146


<210>  14
<211>  4479
<212>  DNA
<213>  Artificial Seuqence

<220>
<223>  Synthetic Polynucleotide

<400>  14
atgcccaatg agggcatccc tcacagcagc cagacacaag agcaggactg cctgcagagc       60

cagcctgtgt ccaacaacga ggaaatggcc atcaagcaag agtctggcgg cgacggcgag      120

gtggaagagt acctgagctt tagaagcgtt ggcgacggcc tgagcacatc tgctgtggga      180

tgtgcttctg ccgctcctag aagaggacct gctctgctgc acatcgaccg gcatcagatt      240

caggccgtgg aaccttctgc acaggccctg gaactgcaag gcctgggagt cgatgtgtac      300

gaccaggacg ttctggaaca gggcgtgctg caacaggtgg acaatgccat tcacgaggcc      360

agcagagcct ctcagctggt ggacgtggaa aaagaatatc ggagcgtgct ggacgacctg      420

accagctgta caaccagcct gcggcagatc aacaagatca tcgagcagct gtctccccag      480

gccgccacca gcagagacat caacagaaag ctggacagcg tgaagcgcca gaagtacaac      540

aaagagcagc agctgaagaa gatcaccgcc aagcagaaac atctgcaggc cattctcggc      600

ggagccgaag tgaagatcga actggatcac gccagcctgg aagaggatgc cgaacctgga      660

ccaagcagcc tgggctctat gctgatgccc gtgcaagaga cagcctggga agaactgatc      720

cggaccggcc agatgacccc tttcggaaca cagatccctc agaagcaaga gaagaaaccc      780

cggaagatca tgctgaacga ggcctccggc ttcgagaagt acctggccga tcaggccaag      840

ctgagcttcg agagaaagaa gcagggctgc aacaagagag ccgccagaaa agctcccgct      900

cctgtgacac ctcctgctcc agtgcagaac aagaacaagc ccaacaagaa agcccgggtg      960

ctgagcaaga aagaggaacg cctgaagaaa cacatcaaga agctgcagaa gcgggccctg     1020

cagtttcaag gcaaagtggg cctgcctaag gccagaaggc cttgggaaag cgacatgagg     1080

cctgaggccg agggcgattc tgagggcgaa gagagcgagt acttccccac cgaggaagaa     1140

gaagaggaag aggacgacga ggttgagggc gccgaagctg atcttagcgg agatggcacc     1200

gactacgagc tgaagcctct gcctaaaggc ggcaagaggc agaaaaaggt gccagtgcaa     1260

gaaatcgacg acgacttctt cccatcctcc ggcgaagaag ccgaagccgc ctctgttgga     1320

gaaggcggcg gaggcggaag aaaagtgggc agatacagag atgacggcga cgaggactac     1380

tacaagcagc ggctgagaag gtggaacaag ctgagactgc aggacaaaga gaagaggctg     1440

aagctggaag atgacagcga ggaatccgac gccgagttcg acgagggctt taaggtgccc     1500

ggcttcctgt ttaagaagct gttcaagtac cagcagaccg gcgtgcggtg gctgtgggaa     1560

ctgcattgtc aacaggcagg cggaatcctg ggcgacgaaa tgggactggg caagacaatc     1620

cagattatcg ccttcctggc cggcctgtcc tacagcaaga tcagaacccg gggcagcaac     1680

tacagattcg aaggactggg ccccaccgtg atcgtgtgtc ctacaacagt gatgcaccag     1740

tgggtcaaag aattccacac ctggtggcct ccattcagag tggccatcct gcacgagaca     1800

ggcagctaca cccacaagaa agaaaagctg atccgcgacg tggcccactg ccacggcatc     1860

ctgatcacaa gctacagcta catccggctg atgcaggacg acatcagcag atacgactgg     1920

cactacgtga tcctggacga gggccacaag attcggaacc ccaatgccgc tgtgaccctg     1980

gcctgcaagc agttcagaac ccctcaccgg atcatcctga gcggcagccc catgcaaaac     2040

aacctgagag agctgtggtc cctgttcgac ttcatcttcc ctggcaagct gggcaccctg     2100

cctgtgttca tggaacagtt cagcgtgccc atcaccatgg gcggctacag caatgcctct     2160

cctgtgcaag tgaaaaccgc ctacaagtgc gcctgcgtgc tgcgggatac catcaatcct     2220

tacctgctgc ggcggatgaa gtccgacgtg aagatgagcc tgagcctgcc tgacaagaac     2280

gaacaggtgc tgttctgccg gctgaccgac gagcagcaca aggtgtacca gaacttcgtg     2340

gacagcaaag aggtgtaccg gatcctgaac ggcgagatgc agatcttcag cggactgatc     2400

gccctgcgga agatctgtaa tcaccccgac ctgttcagcg gcggacccaa gaatctgaag     2460

ggcctgccag acgacgaact cgaggaagat cagtttggct actggaagcg gagcggcaag     2520

atgatcgtgg tggaaagcct gctgaagatt tggcacaagc agggccagag agtgctgctg     2580

ttcagccaga gcagacagat gctggatatc ctggaagtgt tcctgcgggc ccagaagtat     2640

acctacctga agatggacgg caccaccaca atcgccagca gacagcctct gatcacccgg     2700

tacaatgagg atacctccat cttcgtcttt ctgctgacca ccagagtcgg cggactgggc     2760

gttaacctga ctggcgccaa tcgggtcgtg atctatgacc ccgactggaa ccccagcacc     2820

gacacacagg ctagagagag agcttggaga atcggccaga aaaagcaagt gaccgtgtac     2880

cggctgctga ccgccggaac aatcgaagag aagatctacc accggcagat ctttaagcag     2940

ttcctgacca acagggtgct gaaggacccc aagcagagaa gattcttcaa gagcaacgac     3000

ctgtatgagc tgttcaccct gacaagcccc gatgccagcc agtctacaga gacaagcgcc     3060

atctttgccg gcaccggctc tgatgtgcag acccctaagt gtcacctgaa gcggagaatc     3120

cagcctgcct ttggcgccga tcacgacgtg cccaagcgga agaagttccc cgccagcaac     3180

atcagcgtga acgatgccac cagctccgag gaaaagagcg aagccaaagg cgctgaagtg     3240

aacgccgtga ccagcaacag aagcgaccct ctgaaggacg accctcacat gagcagcaac     3300

gtgacctcca acgaccggct gggagaagag acaaatgccg tgtctggccc cgaggaactg     3360

agcgtgatat ctggcaatgg cgagtgcagc aacagctctg gcaccggcaa gacctctatg     3420

ccatctggcg acgagagcat cgacgagaag ctgggcctgt cttacaagag agagcggcct     3480

tctcaggccc agaccgaggc cttttgggag aacaagcaga tggaaaacaa cttctacaag     3540

cacaagtcca agaccaagca ccacagcgtg gccgaagagg aaaccctgga aaagcacctg     3600

aggcctaagc agaagcccaa gaactccaag cactgccggg atgccaagtt cgagggcacc     3660

agaattcccc atctggtcaa gaagcggcgc taccagaagc aggacagcga gaacaagtcc     3720

gaggccaaag aacagtccaa cgacgactac gtgctggaaa aactgttcaa gaaaagcgtg     3780

ggcgtgcaca gcgtgatgaa gcacgacgcc attatggacg gcgctagccc cgattatgtg     3840

ctggtggaag ccgaggctaa tagagtggcc caggatgccc tgaaggccct gagactctcc     3900

agacagagat gtctgggagc tgtgtccggc gtgccaacat ggacaggaca cagaggaatt     3960

tctggcgccc ctgccggcaa gaagtctcgc tttggcaaga agagaaacag caacttctcc     4020

gtgcagcacc cctccagcac aagccctaca gagaagtgcc aggacggcat catgaagaaa     4080

gaaggcaagg acaacgtccc cgagcacttt agcggcagag ccgaggatgc tgatagctct     4140

agtggacctc tggccagcag ttccctgctg gctaagatga gagcccggaa ccacctgatc     4200

ctgccagaga gactggaaag cgagtccggc catctgcaag aagctagcgc actgctgcct     4260

accaccgagc acgatgatct gctggtcgag atgcggaact tcattgcctt tcaagcccac     4320

acagacggcc aggcctctac cagagagatc ctgcaagagt ttgagagcaa gctgtccgcc     4380

tctcagagct gcgtgttcag agagctgctg agaaacctgt gcaccttcca cagaaccagc     4440

ggaggcgaag gcatctggaa gctgaaaccc gagtactgc                            4479


<210>  15
<211>  1185
<212>  PRT
<213>  Homo Sapiens

<400>  15

Met Gly Val Gln Gly Leu Trp Lys Leu Leu Glu Cys Ser Gly Arg Gln 
1               5                   10                  15      


Val Ser Pro Glu Ala Leu Glu Gly Lys Ile Leu Ala Val Asp Ile Ser 
            20                  25                  30          


Ile Trp Leu Asn Gln Ala Leu Lys Gly Val Arg Asp Arg His Gly Asn 
        35                  40                  45              


Ser Ile Glu Asn Pro His Pro Leu Thr Leu Phe His Arg Leu Cys Lys 
    50                  55                  60                  


Leu Leu Phe Phe Arg Ile Arg Pro Ile Phe Val Phe Asp Gly Asp Ala 
65                  70                  75                  80  


Pro Leu Leu Lys Lys Gln Thr Leu Val Lys Arg Arg Gln Arg Lys Asp 
                85                  90                  95      


Leu Ala Ser Ser Asp Ser Arg Lys Thr Thr Glu Lys Leu Leu Lys Thr 
            100                 105                 110         


Phe Leu Lys Arg Gln Ala Ile Gln Thr Ser Phe Arg Ser Gln Arg Asp 
        115                 120                 125             


Glu Ala Leu Pro Ser Leu Thr Gln Val Arg Arg Glu Asn Asp Leu Tyr 
    130                 135                 140                 


Val Leu Pro Pro Leu Gln Glu Glu Glu Lys His Ser Ser Glu Glu Glu 
145                 150                 155                 160 


Asp Glu Lys Glu Trp Gln Glu Arg Met Asn Gln Lys Gln Ala Leu Gln 
                165                 170                 175     


Glu Glu Phe Phe His Asn Pro Gln Ala Ile Asp Ile Glu Ser Glu Asp 
            180                 185                 190         


Phe Ser Ser Leu Pro Pro Glu Val Lys His Glu Ile Leu Thr Asp Met 
        195                 200                 205             


Lys Glu Phe Thr Lys Arg Arg Arg Thr Leu Phe Glu Ala Met Pro Glu 
    210                 215                 220                 


Glu Ser Asp Asp Phe Ser Gln Tyr Gln Leu Lys Gly Leu Leu Lys Lys 
225                 230                 235                 240 


Asn Tyr Leu Asn Gln His Ile Glu His Val Gln Lys Glu Val Asn Gln 
                245                 250                 255     


Gln His Ser Gly His Ile Arg Ser Ser His Glu Asp Glu Gly Gly Phe 
            260                 265                 270         


Leu Lys Glu Val Glu Ser Arg Arg Val Val Ser Glu Asp Thr Ser His 
        275                 280                 285             


Tyr Ile Leu Ile Lys Gly Ile Gln Ala Lys Thr Val Ala Glu Val Asp 
    290                 295                 300                 


Ser Glu Ser Leu Pro Ser Ser Ser Lys Met His Gly Met Ser Phe Asp 
305                 310                 315                 320 


Val Lys Ser Ser Pro Cys Glu Lys Leu Lys Thr Glu Lys Glu Pro Asp 
                325                 330                 335     


Ala Thr Pro Pro Ser Pro Arg Thr Leu Leu Ala Met Gln Ala Ala Leu 
            340                 345                 350         


Leu Gly Ser Ser Ser Glu Glu Glu Leu Glu Ser Glu Asn Arg Arg Gln 
        355                 360                 365             


Ala Arg Gly Arg Asn Ala Pro Ala Ala Val Asp Glu Gly Ser Ile Ser 
    370                 375                 380                 


Pro Arg Thr Leu Ser Ala Ile Lys Arg Ala Leu Asp Asp Asp Glu Asp 
385                 390                 395                 400 


Val Lys Val Cys Ala Gly Asp Asp Val Gln Thr Gly Gly Pro Gly Ala 
                405                 410                 415     


Glu Glu Met Arg Ile Asn Ser Ser Thr Glu Asn Ser Asp Glu Gly Leu 
            420                 425                 430         


Lys Val Arg Asp Gly Lys Gly Ile Pro Phe Thr Ala Thr Leu Ala Ser 
        435                 440                 445             


Ser Ser Val Asn Ser Ala Glu Glu His Val Ala Ser Thr Asn Glu Gly 
    450                 455                 460                 


Arg Glu Pro Thr Asp Ser Val Pro Lys Glu Gln Met Ser Leu Val His 
465                 470                 475                 480 


Val Gly Thr Glu Ala Phe Pro Ile Ser Asp Glu Ser Met Ile Lys Asp 
                485                 490                 495     


Arg Lys Asp Arg Leu Pro Leu Glu Ser Ala Val Val Arg His Ser Asp 
            500                 505                 510         


Ala Pro Gly Leu Pro Asn Gly Arg Glu Leu Thr Pro Ala Ser Pro Thr 
        515                 520                 525             


Cys Thr Asn Ser Val Ser Lys Asn Glu Thr His Ala Glu Val Leu Glu 
    530                 535                 540                 


Gln Gln Asn Glu Leu Cys Pro Tyr Glu Ser Lys Phe Asp Ser Ser Leu 
545                 550                 555                 560 


Leu Ser Ser Asp Asp Glu Thr Lys Cys Lys Pro Asn Ser Ala Ser Glu 
                565                 570                 575     


Val Ile Gly Pro Val Ser Leu Gln Glu Thr Ser Ser Ile Val Ser Val 
            580                 585                 590         


Pro Ser Glu Ala Val Asp Asn Val Glu Asn Val Val Ser Phe Asn Ala 
        595                 600                 605             


Lys Glu His Glu Asn Phe Leu Glu Thr Ile Gln Glu Gln Gln Thr Thr 
    610                 615                 620                 


Glu Ser Ala Gly Gln Asp Leu Ile Ser Ile Pro Lys Ala Val Glu Pro 
625                 630                 635                 640 


Met Glu Ile Asp Ser Glu Glu Ser Glu Ser Asp Gly Ser Phe Ile Glu 
                645                 650                 655     


Val Gln Ser Val Ile Ser Asp Glu Glu Leu Gln Ala Glu Phe Pro Glu 
            660                 665                 670         


Thr Ser Lys Pro Pro Ser Glu Gln Gly Glu Glu Glu Leu Val Gly Thr 
        675                 680                 685             


Arg Glu Gly Glu Ala Pro Ala Glu Ser Glu Ser Leu Leu Arg Asp Asn 
    690                 695                 700                 


Ser Glu Arg Asp Asp Val Asp Gly Glu Pro Gln Glu Ala Glu Lys Asp 
705                 710                 715                 720 


Ala Glu Asp Ser Leu His Glu Trp Gln Asp Ile Asn Leu Glu Glu Leu 
                725                 730                 735     


Glu Thr Leu Glu Ser Asn Leu Leu Ala Gln Gln Asn Ser Leu Lys Ala 
            740                 745                 750         


Gln Lys Gln Gln Gln Glu Arg Phe Ala Ala Thr Val Thr Gly Gln Met 
        755                 760                 765             


Phe Leu Glu Ser Gln Glu Leu Leu Arg Leu Phe Gly Ile Pro Tyr Ile 
    770                 775                 780                 


Gln Ala Pro Met Glu Ala Glu Ala Gln Cys Ala Val Leu Asp Leu Thr 
785                 790                 795                 800 


Asp Gln Thr Ser Gly Thr Ile Thr Asp Asp Ser Asp Ile Trp Leu Phe 
                805                 810                 815     


Gly Ala Arg His Val Tyr Arg Asn Phe Phe Asn Lys Asn Lys Phe Val 
            820                 825                 830         


Glu Tyr Tyr Gln Tyr Val Asp Phe His Asn Gln Leu Gly Leu Asp Arg 
        835                 840                 845             


Asn Lys Leu Ile Asn Leu Ala Tyr Leu Leu Gly Ser Asp Tyr Thr Gly 
    850                 855                 860                 


Asn Thr Asn Cys Gly Leu Cys Thr Ala Met Glu Ile Leu Asn Glu Phe 
865                 870                 875                 880 


Pro Gly His Gly Leu Glu Pro Leu Leu Lys Phe Ser Glu Trp Trp His 
                885                 890                 895     


Glu Ala Gln Lys Asn Pro Lys Ile Arg Pro Asn Pro His Asp Thr Lys 
            900                 905                 910         


Val Lys Lys Lys Leu Arg Thr Leu Gln Leu Thr Pro Gly Phe Pro Asn 
        915                 920                 925             


Pro Ala Val Ala Glu Ala Tyr Leu Lys Pro Val Val Asp Asp Ser Lys 
    930                 935                 940                 


Gly Ser Phe Leu Trp Gly Lys Pro Asp Leu Asp Lys Ile Ser Glu Phe 
945                 950                 955                 960 


Cys Gln Arg Tyr Phe Gly Trp Asn Arg Thr Lys Thr Asp Glu Ser Leu 
                965                 970                 975     


Phe Pro Val Leu Lys Gln Leu Asp Ala Gln Gln Thr Gln Leu Arg Ile 
            980                 985                 990         


Asp Ser Phe Phe Arg Leu Ala Gln  Gln Glu Lys Glu Asp  Ala Lys Arg 
        995                 1000                 1005             


Ile Lys  Ser Gln Arg Leu Asn  Arg Ala Val Thr Cys  Met Leu Arg 
    1010                 1015                 1020             


Lys Glu  Lys Glu Ala Ala Ala  Ser Glu Ile Glu Ala  Val Ser Val 
    1025                 1030                 1035             


Ala Met  Glu Lys Glu Phe Glu  Leu Leu Asp Lys Ala  Lys Arg Lys 
    1040                 1045                 1050             


Thr Gln  Lys Arg Gly Ile Thr  Asn Thr Leu Glu Glu  Ser Ser Ser 
    1055                 1060                 1065             


Leu Lys  Arg Lys Arg Leu Ser  Asp Ser Lys Arg Lys  Asn Thr Cys 
    1070                 1075                 1080             


Gly Gly  Phe Leu Gly Glu Thr  Cys Leu Ser Glu Ser  Ser Asp Gly 
    1085                 1090                 1095             


Ser Ser  Ser Glu Asp Ala Glu  Ser Ser Ser Leu Met  Asn Val Gln 
    1100                 1105                 1110             


Arg Arg  Thr Ala Ala Lys Glu  Pro Lys Thr Ser Ala  Ser Asp Ser 
    1115                 1120                 1125             


Gln Asn  Ser Val Lys Glu Ala  Pro Val Lys Asn Gly  Gly Ala Thr 
    1130                 1135                 1140             


Thr Ser  Ser Ser Ser Asp Ser  Asp Asp Asp Gly Gly  Lys Glu Lys 
    1145                 1150                 1155             


Met Val  Leu Val Thr Ala Arg  Ser Val Phe Gly Lys  Lys Arg Arg 
    1160                 1165                 1170             


Lys Leu  Arg Arg Ala Arg Gly  Arg Lys Arg Lys Thr  
    1175                 1180                 1185 


<210>  16
<211>  396
<212>  PRT
<213>  Homo Sapiens

<400>  16

Met Leu Gly Phe Leu Ser Ala Arg Gln Thr Gly Leu Glu Asp Pro Leu 
1               5                   10                  15      


Arg Leu Arg Arg Ala Glu Ser Thr Arg Arg Val Leu Gly Leu Glu Leu 
            20                  25                  30          


Asn Lys Asp Arg Asp Val Glu Arg Ile His Gly Gly Gly Ile Asn Thr 
        35                  40                  45              


Leu Asp Ile Glu Pro Val Glu Gly Arg Tyr Met Leu Ser Gly Gly Ser 
    50                  55                  60                  


Asp Gly Val Ile Val Leu Tyr Asp Leu Glu Asn Ser Ser Arg Gln Ser 
65                  70                  75                  80  


Tyr Tyr Thr Cys Lys Ala Val Cys Ser Ile Gly Arg Asp His Pro Asp 
                85                  90                  95      


Val His Arg Tyr Ser Val Glu Thr Val Gln Trp Tyr Pro His Asp Thr 
            100                 105                 110         


Gly Met Phe Thr Ser Ser Ser Phe Asp Lys Thr Leu Lys Val Trp Asp 
        115                 120                 125             


Thr Asn Thr Leu Gln Thr Ala Asp Val Phe Asn Phe Glu Glu Thr Val 
    130                 135                 140                 


Tyr Ser His His Met Ser Pro Val Ser Thr Lys His Cys Leu Val Ala 
145                 150                 155                 160 


Val Gly Thr Arg Gly Pro Lys Val Gln Leu Cys Asp Leu Lys Ser Gly 
                165                 170                 175     


Ser Cys Ser His Ile Leu Gln Gly His Arg Gln Glu Ile Leu Ala Val 
            180                 185                 190         


Ser Trp Ser Pro Arg Tyr Asp Tyr Ile Leu Ala Thr Ala Ser Ala Asp 
        195                 200                 205             


Ser Arg Val Lys Leu Trp Asp Val Arg Arg Ala Ser Gly Cys Leu Ile 
    210                 215                 220                 


Thr Leu Asp Gln His Asn Gly Lys Lys Ser Gln Ala Val Glu Ser Ala 
225                 230                 235                 240 


Asn Thr Ala His Asn Gly Lys Val Asn Gly Leu Cys Phe Thr Ser Asp 
                245                 250                 255     


Gly Leu His Leu Leu Thr Val Gly Thr Asp Asn Arg Met Arg Leu Trp 
            260                 265                 270         


Asn Ser Ser Asn Gly Glu Asn Thr Leu Val Asn Tyr Gly Lys Val Cys 
        275                 280                 285             


Asn Asn Ser Lys Lys Gly Leu Lys Phe Thr Val Ser Cys Gly Cys Ser 
    290                 295                 300                 


Ser Glu Phe Val Phe Val Pro Tyr Gly Ser Thr Ile Ala Val Tyr Thr 
305                 310                 315                 320 


Val Tyr Ser Gly Glu Gln Ile Thr Met Leu Lys Gly His Tyr Lys Thr 
                325                 330                 335     


Val Asp Cys Cys Val Phe Gln Ser Asn Phe Gln Glu Leu Tyr Ser Gly 
            340                 345                 350         


Ser Arg Asp Cys Asn Ile Leu Ala Trp Val Pro Ser Leu Tyr Glu Pro 
        355                 360                 365             


Val Pro Asp Asp Asp Glu Thr Thr Thr Lys Ser Gln Leu Asn Pro Ala 
    370                 375                 380                 


Phe Glu Asp Ala Trp Ser Ser Ser Asp Glu Glu Gly 
385                 390                 395     


<210>  17
<211>  1493
<212>  PRT
<213>  Homo Sapiens

<400>  17

Met Pro Asn Glu Gly Ile Pro His Ser Ser Gln Thr Gln Glu Gln Asp 
1               5                   10                  15      


Cys Leu Gln Ser Gln Pro Val Ser Asn Asn Glu Glu Met Ala Ile Lys 
            20                  25                  30          


Gln Glu Ser Gly Gly Asp Gly Glu Val Glu Glu Tyr Leu Ser Phe Arg 
        35                  40                  45              


Ser Val Gly Asp Gly Leu Ser Thr Ser Ala Val Gly Cys Ala Ser Ala 
    50                  55                  60                  


Ala Pro Arg Arg Gly Pro Ala Leu Leu His Ile Asp Arg His Gln Ile 
65                  70                  75                  80  


Gln Ala Val Glu Pro Ser Ala Gln Ala Leu Glu Leu Gln Gly Leu Gly 
                85                  90                  95      


Val Asp Val Tyr Asp Gln Asp Val Leu Glu Gln Gly Val Leu Gln Gln 
            100                 105                 110         


Val Asp Asn Ala Ile His Glu Ala Ser Arg Ala Ser Gln Leu Val Asp 
        115                 120                 125             


Val Glu Lys Glu Tyr Arg Ser Val Leu Asp Asp Leu Thr Ser Cys Thr 
    130                 135                 140                 


Thr Ser Leu Arg Gln Ile Asn Lys Ile Ile Glu Gln Leu Ser Pro Gln 
145                 150                 155                 160 


Ala Ala Thr Ser Arg Asp Ile Asn Arg Lys Leu Asp Ser Val Lys Arg 
                165                 170                 175     


Gln Lys Tyr Asn Lys Glu Gln Gln Leu Lys Lys Ile Thr Ala Lys Gln 
            180                 185                 190         


Lys His Leu Gln Ala Ile Leu Gly Gly Ala Glu Val Lys Ile Glu Leu 
        195                 200                 205             


Asp His Ala Ser Leu Glu Glu Asp Ala Glu Pro Gly Pro Ser Ser Leu 
    210                 215                 220                 


Gly Ser Met Leu Met Pro Val Gln Glu Thr Ala Trp Glu Glu Leu Ile 
225                 230                 235                 240 


Arg Thr Gly Gln Met Thr Pro Phe Gly Thr Gln Ile Pro Gln Lys Gln 
                245                 250                 255     


Glu Lys Lys Pro Arg Lys Ile Met Leu Asn Glu Ala Ser Gly Phe Glu 
            260                 265                 270         


Lys Tyr Leu Ala Asp Gln Ala Lys Leu Ser Phe Glu Arg Lys Lys Gln 
        275                 280                 285             


Gly Cys Asn Lys Arg Ala Ala Arg Lys Ala Pro Ala Pro Val Thr Pro 
    290                 295                 300                 


Pro Ala Pro Val Gln Asn Lys Asn Lys Pro Asn Lys Lys Ala Arg Val 
305                 310                 315                 320 


Leu Ser Lys Lys Glu Glu Arg Leu Lys Lys His Ile Lys Lys Leu Gln 
                325                 330                 335     


Lys Arg Ala Leu Gln Phe Gln Gly Lys Val Gly Leu Pro Lys Ala Arg 
            340                 345                 350         


Arg Pro Trp Glu Ser Asp Met Arg Pro Glu Ala Glu Gly Asp Ser Glu 
        355                 360                 365             


Gly Glu Glu Ser Glu Tyr Phe Pro Thr Glu Glu Glu Glu Glu Glu Glu 
    370                 375                 380                 


Asp Asp Glu Val Glu Gly Ala Glu Ala Asp Leu Ser Gly Asp Gly Thr 
385                 390                 395                 400 


Asp Tyr Glu Leu Lys Pro Leu Pro Lys Gly Gly Lys Arg Gln Lys Lys 
                405                 410                 415     


Val Pro Val Gln Glu Ile Asp Asp Asp Phe Phe Pro Ser Ser Gly Glu 
            420                 425                 430         


Glu Ala Glu Ala Ala Ser Val Gly Glu Gly Gly Gly Gly Gly Arg Lys 
        435                 440                 445             


Val Gly Arg Tyr Arg Asp Asp Gly Asp Glu Asp Tyr Tyr Lys Gln Arg 
    450                 455                 460                 


Leu Arg Arg Trp Asn Lys Leu Arg Leu Gln Asp Lys Glu Lys Arg Leu 
465                 470                 475                 480 


Lys Leu Glu Asp Asp Ser Glu Glu Ser Asp Ala Glu Phe Asp Glu Gly 
                485                 490                 495     


Phe Lys Val Pro Gly Phe Leu Phe Lys Lys Leu Phe Lys Tyr Gln Gln 
            500                 505                 510         


Thr Gly Val Arg Trp Leu Trp Glu Leu His Cys Gln Gln Ala Gly Gly 
        515                 520                 525             


Ile Leu Gly Asp Glu Met Gly Leu Gly Lys Thr Ile Gln Ile Ile Ala 
    530                 535                 540                 


Phe Leu Ala Gly Leu Ser Tyr Ser Lys Ile Arg Thr Arg Gly Ser Asn 
545                 550                 555                 560 


Tyr Arg Phe Glu Gly Leu Gly Pro Thr Val Ile Val Cys Pro Thr Thr 
                565                 570                 575     


Val Met His Gln Trp Val Lys Glu Phe His Thr Trp Trp Pro Pro Phe 
            580                 585                 590         


Arg Val Ala Ile Leu His Glu Thr Gly Ser Tyr Thr His Lys Lys Glu 
        595                 600                 605             


Lys Leu Ile Arg Asp Val Ala His Cys His Gly Ile Leu Ile Thr Ser 
    610                 615                 620                 


Tyr Ser Tyr Ile Arg Leu Met Gln Asp Asp Ile Ser Arg Tyr Asp Trp 
625                 630                 635                 640 


His Tyr Val Ile Leu Asp Glu Gly His Lys Ile Arg Asn Pro Asn Ala 
                645                 650                 655     


Ala Val Thr Leu Ala Cys Lys Gln Phe Arg Thr Pro His Arg Ile Ile 
            660                 665                 670         


Leu Ser Gly Ser Pro Met Gln Asn Asn Leu Arg Glu Leu Trp Ser Leu 
        675                 680                 685             


Phe Asp Phe Ile Phe Pro Gly Lys Leu Gly Thr Leu Pro Val Phe Met 
    690                 695                 700                 


Glu Gln Phe Ser Val Pro Ile Thr Met Gly Gly Tyr Ser Asn Ala Ser 
705                 710                 715                 720 


Pro Val Gln Val Lys Thr Ala Tyr Lys Cys Ala Cys Val Leu Arg Asp 
                725                 730                 735     


Thr Ile Asn Pro Tyr Leu Leu Arg Arg Met Lys Ser Asp Val Lys Met 
            740                 745                 750         


Ser Leu Ser Leu Pro Asp Lys Asn Glu Gln Val Leu Phe Cys Arg Leu 
        755                 760                 765             


Thr Asp Glu Gln His Lys Val Tyr Gln Asn Phe Val Asp Ser Lys Glu 
    770                 775                 780                 


Val Tyr Arg Ile Leu Asn Gly Glu Met Gln Ile Phe Ser Gly Leu Ile 
785                 790                 795                 800 


Ala Leu Arg Lys Ile Cys Asn His Pro Asp Leu Phe Ser Gly Gly Pro 
                805                 810                 815     


Lys Asn Leu Lys Gly Leu Pro Asp Asp Glu Leu Glu Glu Asp Gln Phe 
            820                 825                 830         


Gly Tyr Trp Lys Arg Ser Gly Lys Met Ile Val Val Glu Ser Leu Leu 
        835                 840                 845             


Lys Ile Trp His Lys Gln Gly Gln Arg Val Leu Leu Phe Ser Gln Ser 
    850                 855                 860                 


Arg Gln Met Leu Asp Ile Leu Glu Val Phe Leu Arg Ala Gln Lys Tyr 
865                 870                 875                 880 


Thr Tyr Leu Lys Met Asp Gly Thr Thr Thr Ile Ala Ser Arg Gln Pro 
                885                 890                 895     


Leu Ile Thr Arg Tyr Asn Glu Asp Thr Ser Ile Phe Val Phe Leu Leu 
            900                 905                 910         


Thr Thr Arg Val Gly Gly Leu Gly Val Asn Leu Thr Gly Ala Asn Arg 
        915                 920                 925             


Val Val Ile Tyr Asp Pro Asp Trp Asn Pro Ser Thr Asp Thr Gln Ala 
    930                 935                 940                 


Arg Glu Arg Ala Trp Arg Ile Gly Gln Lys Lys Gln Val Thr Val Tyr 
945                 950                 955                 960 


Arg Leu Leu Thr Ala Gly Thr Ile Glu Glu Lys Ile Tyr His Arg Gln 
                965                 970                 975     


Ile Phe Lys Gln Phe Leu Thr Asn Arg Val Leu Lys Asp Pro Lys Gln 
            980                 985                 990         


Arg Arg Phe Phe Lys Ser Asn Asp  Leu Tyr Glu Leu Phe  Thr Leu Thr 
        995                 1000                 1005             


Ser Pro  Asp Ala Ser Gln Ser  Thr Glu Thr Ser Ala  Ile Phe Ala 
    1010                 1015                 1020             


Gly Thr  Gly Ser Asp Val Gln  Thr Pro Lys Cys His  Leu Lys Arg 
    1025                 1030                 1035             


Arg Ile  Gln Pro Ala Phe Gly  Ala Asp His Asp Val  Pro Lys Arg 
    1040                 1045                 1050             


Lys Lys  Phe Pro Ala Ser Asn  Ile Ser Val Asn Asp  Ala Thr Ser 
    1055                 1060                 1065             


Ser Glu  Glu Lys Ser Glu Ala  Lys Gly Ala Glu Val  Asn Ala Val 
    1070                 1075                 1080             


Thr Ser  Asn Arg Ser Asp Pro  Leu Lys Asp Asp Pro  His Met Ser 
    1085                 1090                 1095             


Ser Asn  Val Thr Ser Asn Asp  Arg Leu Gly Glu Glu  Thr Asn Ala 
    1100                 1105                 1110             


Val Ser  Gly Pro Glu Glu Leu  Ser Val Ile Ser Gly  Asn Gly Glu 
    1115                 1120                 1125             


Cys Ser  Asn Ser Ser Gly Thr  Gly Lys Thr Ser Met  Pro Ser Gly 
    1130                 1135                 1140             


Asp Glu  Ser Ile Asp Glu Lys  Leu Gly Leu Ser Tyr  Lys Arg Glu 
    1145                 1150                 1155             


Arg Pro  Ser Gln Ala Gln Thr  Glu Ala Phe Trp Glu  Asn Lys Gln 
    1160                 1165                 1170             


Met Glu  Asn Asn Phe Tyr Lys  His Lys Ser Lys Thr  Lys His His 
    1175                 1180                 1185             


Ser Val  Ala Glu Glu Glu Thr  Leu Glu Lys His Leu  Arg Pro Lys 
    1190                 1195                 1200             


Gln Lys  Pro Lys Asn Ser Lys  His Cys Arg Asp Ala  Lys Phe Glu 
    1205                 1210                 1215             


Gly Thr  Arg Ile Pro His Leu  Val Lys Lys Arg Arg  Tyr Gln Lys 
    1220                 1225                 1230             


Gln Asp  Ser Glu Asn Lys Ser  Glu Ala Lys Glu Gln  Ser Asn Asp 
    1235                 1240                 1245             


Asp Tyr  Val Leu Glu Lys Leu  Phe Lys Lys Ser Val  Gly Val His 
    1250                 1255                 1260             


Ser Val  Met Lys His Asp Ala  Ile Met Asp Gly Ala  Ser Pro Asp 
    1265                 1270                 1275             


Tyr Val  Leu Val Glu Ala Glu  Ala Asn Arg Val Ala  Gln Asp Ala 
    1280                 1285                 1290             


Leu Lys  Ala Leu Arg Leu Ser  Arg Gln Arg Cys Leu  Gly Ala Val 
    1295                 1300                 1305             


Ser Gly  Val Pro Thr Trp Thr  Gly His Arg Gly Ile  Ser Gly Ala 
    1310                 1315                 1320             


Pro Ala  Gly Lys Lys Ser Arg  Phe Gly Lys Lys Arg  Asn Ser Asn 
    1325                 1330                 1335             


Phe Ser  Val Gln His Pro Ser  Ser Thr Ser Pro Thr  Glu Lys Cys 
    1340                 1345                 1350             


Gln Asp  Gly Ile Met Lys Lys  Glu Gly Lys Asp Asn  Val Pro Glu 
    1355                 1360                 1365             


His Phe  Ser Gly Arg Ala Glu  Asp Ala Asp Ser Ser  Ser Gly Pro 
    1370                 1375                 1380             


Leu Ala  Ser Ser Ser Leu Leu  Ala Lys Met Arg Ala  Arg Asn His 
    1385                 1390                 1395             


Leu Ile  Leu Pro Glu Arg Leu  Glu Ser Glu Ser Gly  His Leu Gln 
    1400                 1405                 1410             


Glu Ala  Ser Ala Leu Leu Pro  Thr Thr Glu His Asp  Asp Leu Leu 
    1415                 1420                 1425             


Val Glu  Met Arg Asn Phe Ile  Ala Phe Gln Ala His  Thr Asp Gly 
    1430                 1435                 1440             


Gln Ala  Ser Thr Arg Glu Ile  Leu Gln Glu Phe Glu  Ser Lys Leu 
    1445                 1450                 1455             


Ser Ala  Ser Gln Ser Cys Val  Phe Arg Glu Leu Leu  Arg Asn Leu 
    1460                 1465                 1470             


Cys Thr  Phe His Arg Thr Ser  Gly Gly Glu Gly Ile  Trp Lys Leu 
    1475                 1480                 1485             


Lys Pro  Glu Tyr Cys 
    1490             


