                         SEQUENCE LISTING

<110>  THE ROCKEFELLER UNIVERSITY
 
<120>  ANTIBODY GENE EDITING IN B LYMPHOCYTES

<130>  076091.00106

<150>  62/991,482
<151>  2020-03-18

<160>  56    

<170>  PatentIn version 3.5

<210>  1
<211>  18
<212>  PRT
<213>  artificial sequence

<220>
<223>  skipping sequence

<400>  1

Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro 
1               5                   10                  15      


Gly Pro 
        


<210>  2
<211>  19
<212>  PRT
<213>  artificial sequence

<220>
<223>  skipping sequence

<400>  2

Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn 
1               5                   10                  15      


Pro Gly Pro 
            


<210>  3
<211>  20
<212>  PRT
<213>  artificial sequence

<220>
<223>  skipping sequence

<400>  3

Gln Cys Thr Asn Tyr Ala Leu Leu Lys Leu Ala Gly Asp Val Glu Ser 
1               5                   10                  15      


Asn Pro Gly Pro 
            20  


<210>  4
<211>  22
<212>  PRT
<213>  artificial sequence

<220>
<223>  skipping sequence

<400>  4

Val Lys Gln Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val 
1               5                   10                  15      


Glu Ser Asn Pro Gly Pro 
            20          


<210>  5
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  guide RNA per DNA sequence

<400>  5
gttcaagaag cacacgactg                                                   20


<210>  6
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  guide RNA per DNA sequence

<400>  6
gttaactgct cactggatgg                                                   20


<210>  7
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  guide RNA per DNA sequence

<400>  7
ggagccggct gagagaagtt                                                   20


<210>  8
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  guide RNA per DNA sequence

<400>  8
gtggagataa tctgtcctaa                                                   20


<210>  9
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  guide RNA per DNA sequence

<400>  9
agtccctatc ccatcatcca                                                   20


<210>  10
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  guide RNA per DNA sequence

<400>  10
tgagcattgc agactaatct                                                   20


<210>  11
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  guide RNA per DNA sequence

<400>  11
aagtccctat cccatcatcc                                                   20


<210>  12
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  guide RNA per DNA sequence

<400>  12
tcttggatat ttgtccctga                                                   20


<210>  13
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  guide RNA per DNA sequenc

<400>  13
gttgggaaat aaactgtcta                                                   20


<210>  14
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  guide RNA per DNA sequence

<400>  14
ggtggataac gccctccaat                                                   20


<210>  15
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  guide RNA per DNA sequence

<400>  15
gtggataacg ccctccaatc                                                   20


<210>  16
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  guide RNA per DNA sequence

<400>  16
ctgggagtta cccgattgga                                                   20


<210>  17
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  guide RNA per DNA sequence

<400>  17
cctccaatcg ggtaactccc                                                   20


<210>  18
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  guide RNA per DNA sequence

<400>  18
atccaccttc cactgtactt                                                   20


<210>  19
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  guide RNA per DNA sequence

<400>  19
ttcaactgct catcagatgg                                                   20


<210>  20
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  guide RNA per DNA sequence

<400>  20
gatttcaact gctcatcaga                                                   20


<210>  21
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  guide RNA per DNA sequence

<400>  21
tgggatagaa gttattcagc                                                   20


<210>  22
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  guide RNA per DNA sequence

<400>  22
attcagcagg cacacaacag                                                   20


<210>  23
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  guide RNA per DNA sequence

<400>  23
ggccaaagta cagtggaagg                                                   20


<210>  24
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  guide RNA per DNA sequence

<400>  24
gtcctcgggg catgttccga                                                   20


<210>  25
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  uide RNA per DNA sequence

<400>  25
tcctcggggc atgttccgag                                                   20


<210>  26
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  guide RNA per DNA sequence

<400>  26
aggcatcgga aaatccacag                                                   20


<210>  27
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  guide RNA per DNA sequence

<400>  27
ctcaggttgg gtgcgtctga                                                   20


<210>  28
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  guide RNA per DNA sequence

<400>  28
acgagatgcc tgaacaaacc                                                   20


<210>  29
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  guide RNA per DNA sequence

<400>  29
acctgagtcc cattttccaa                                                   20


<210>  30
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  guide RNA per DNA sequence

<400>  30
tcagccatca ctaagacccc                                                   20


<210>  31
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  guide RNA per DNA sequence

<400>  31
caaaccaggg gtcttagtga                                                   20


<210>  32
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  guide RNA per DNA sequence

<400>  32
ctaagacccc tggtttgttc                                                   20


<210>  33
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  guide RNA per DNA sequence

<400>  33
tcaggcatct cgtccaaatg                                                   20


<210>  34
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  guide RNA per DNA sequence

<400>  34
aagacacagg ttttcatgtt                                                   20


<210>  35
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  guide RNA per DNA sequence

<400>  35
gggctcatta tcagttgacg                                                   20


<210>  36
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  guide RNA per DNA sequence

<400>  36
ggtcttctag acgtttaagt                                                   20


<210>  37
<211>  2868
<212>  DNA
<213>  artificial sequence

<220>
<223>  gBlock sequence

<400>  37
gcatagctag cgctcttcag taagaatggc ctctccaggt ctttattttt aacctttgtt       60

atggagtttt ctgagcattg cagactaatc ttggatattt gtccctgagg gagccggctg      120

agagaagtta agagtagcaa caaggaaata gcagggtgta gagggatctc ctgtctgaca      180

ggaggcaaga agacagattc ttacccctcc atttctcttt tatccctctc tggtcctcag      240

agagttagaa cttgtttatt gcagcttata atggttacaa ataaagcaat agcatcacaa      300

atttcacaaa taaagcattt ttttcactgc attctagttg tggtttgtcc aaactcatca      360

atgtatctta tcatgtctgg tcgacagtat gcagagggct gtatccactg gagaggatga      420

agtcactgag ttggaaaaca gaacaggaca ggcacctaac aagtggttgc tatagcccac      480

tgttaccctt ttacatgtat aggctcagga taagcagtga tactgtgagg tttatgtgtg      540

agaacatcac agtataaaca catctcaata gaggtcttag agatcagcac aattagtgag      600

aagtcataaa cagtagatac tataaggcat aggctcagct acctagggtc aggtatctgt      660

gtaaatctga ttgtgtatca ggtttagatc aatatgactt agggaggcga gtcatatgca      720

aatctaagaa gactttagag aagaaatctg aggctcacct cacataacag caagagagtg      780

tccggttagt ctcaaggaag actgagacac agtcttagat atcaccatgg gatggtcatg      840

tatcatcctt tttctagtag caactgcaac cggtgtacat tctgacatcc agatgaccca      900

gtctccatcc tccctgtctg catctgtagg agacagagtc accatcactt gccaggcgag      960

tcaggacatt agcaactatt taaattggta tcagcagaaa ccagggaaag cccctaagct     1020

cctgatctac gatgcatcca atttggaaac aggggtccca tcaaggttca gtggaagtgg     1080

atctgggaca gattttactt tcaccatcag cagcctgcag cctgaagata ttgcaacata     1140

ttactgtcaa cagtatgagt ttatcggccc tgggaccaaa gtggatatca aacgggctga     1200

tgctgcacca actgtatcca tcttctcacc atccagtgag cagttaacat ctggaggtgc     1260

ttcagtcgtg tgcttcttga acaacttcta ccccaaagac atcaatgtca agtggaagat     1320

tgatggcagt gaacgacaaa atggcgtcct gaacagttgg actgatcagg acagcaaaga     1380

cagcacctac agcatgagca gcaccctcac gttgaccaag gacgagtatg aacgacataa     1440

cagctatacc tgtgaggcca ctcacaagac atcaacttca cccattgtca agagcttcaa     1500

caggaatgag tgtaggcgga agcgggggtc aggagcaacc aacttttctc tgctgaagca     1560

agccggggac gtagaggaaa accccggacc catgggatgg tcatgtatca tcctttttct     1620

agtagcaact gcaaccggtg tacattctca ggtccatttg tcacagtctg gggcagcggt     1680

gacgaagccc ggggcctcag tgagagtctc ctgcgaggct tccggataca agattagtga     1740

ccactttatt cattggtggc gacaggcccc aggacagggc cttcagtggg tggggtggat     1800

caatcctaag actggtcagc caaacaatcc tcgtcaattt cagggtagag tcagtctgac     1860

tcgacaggcg tcgtgggact ttgacacata ttccttttac atggacctca aggcagtaag     1920

atcggacgac acggccattt atttctgtgc gcgacaacgc agcgactttt gggatttcga     1980

cgtctggggc agcggcacgc aggtcactgt ctcgtcaggt aagctggctt ttttctttct     2040

gcacattcca ttctgaaacg ggatcgattg ggaaataaac tgtctaggga tctcagagcc     2100

tttaggacag attatctcca catctttgaa aaactaagaa tctgtgtgat ggtgttggtg     2160

gagtccctgg atgatgggat agggactttg gaggctcatt tgaagaagat gctaaaacaa     2220

tcctatggct ggagggatag ttggggctgt agttggagat tttcagtttt tagaataaaa     2280

gtattagttg tggaatatac ttcaggacca cctctgtgac agcatttata cagtatccga     2340

tgcataggga caaagagtgg agtggggcac tttctttaga tttgtgagga atgttccgca     2400

ctagattgtt taaaacttca tttgttggaa ggagagctgt cttagtgatt gagtcaaggg     2460

agaaaggcat ctagcctcgg tctcaaaagg gtagttgctg tctagagagg tctggtggag     2520

cctgcaaaag tccagctttc aaaggaacac agaagtatgt gtatggaata ttagaagatg     2580

ttgcttttac tcttaagttg gttcctagga aaaatagtta aatactgtga ctttaaaatg     2640

tgagagggtt ttcaagtact cattttttta aatgtccaaa attcttgtca atcagtttga     2700

ggtcttgttt gtgtagaact gatattactt aaagtttaac cgaggaatgg gagtgaggct     2760

ctctcataac ctattcagaa ctgactttta acaataataa attaagtttc aaatattttt     2820

aaatgaattg agcaatgttg agttggagtc aagatggcct cgaggaat                  2868


<210>  38
<211>  2347
<212>  DNA
<213>  artificial sequence

<220>
<223>  gBlock sequence

<400>  38
gcatagctag cgctcttcag taagaatggc ctctccaggt ctttattttt aacctttgtt       60

atggagtttt ctgagcattg cagactaatc ttggatattt gtccctgagg gagccggctg      120

agagaagtta agagtagcaa caaggaaata gcagggtgta gagggatctc ctgtctgaca      180

ggaggcaaga agacagattc ttacccctcc atttctcttt tatccctctc tggtcctcag      240

agggaagcgg agagggcaga ggaagtctgc taacatgcgg tgacgtcgag gagaatcctg      300

gacctatggg atggtcatgt atcatccttt ttctagtagc aactgcaacc ggtgtacatt      360

ctgacatcca gatgacccag tctccatcct ccctgtctgc atctgtagga gacagagtca      420

ccatcacttg ccaggcgagt caggacatta gcaactattt aaattggtat cagcagaaac      480

cagggaaagc ccctaagctc ctgatctacg atgcatccaa tttggaaaca ggggtcccat      540

caaggttcag tggaagtgga tctgggacag attttacttt caccatcagc agcctgcagc      600

ctgaagatat tgcaacatat tactgtcaac agtatgagtt tatcggccct gggaccaaag      660

tggatatcaa acgggctgat gctgcaccaa ctgtatccat cttctcacca tccagtgagc      720

agttaacatc tggaggtgct tcagtcgtgt gcttcttgaa caacttctac cccaaagaca      780

tcaatgtcaa gtggaagatt gatggcagtg aacgacaaaa tggcgtcctg aacagttgga      840

ctgatcagga cagcaaagac agcacctaca gcatgagcag caccctcacg ttgaccaagg      900

acgagtatga acgacataac agctatacct gtgaggccac tcacaagaca tcaacttcac      960

ccattgtcaa gagcttcaac aggaatgagt gtaggcggaa gcgggggtca ggagcaacca     1020

acttttctct gctgaagcaa gccggggacg tagaggaaaa ccccggaccc atgggatggt     1080

catgtatcat cctttttcta gtagcaactg caaccggtgt acattctcag gtccatttgt     1140

cacagtctgg ggcagcggtg acgaagcccg gggcctcagt gagagtctcc tgcgaggctt     1200

ccggatacaa gattagtgac cactttattc attggtggcg acaggcccca ggacagggcc     1260

ttcagtgggt ggggtggatc aatcctaaga ctggtcagcc aaacaatcct cgtcaatttc     1320

agggtagagt cagtctgact cgacaggcgt cgtgggactt tgacacatat tccttttaca     1380

tggacctcaa ggcagtaaga tcggacgaca cggccattta tttctgtgcg cgacaacgca     1440

gcgacttttg ggatttcgac gtctggggca gcggcacgca ggtcactgtc tcgtcaggta     1500

agctggcttt tttctttctg cacattccat tctgaaacgg gatcgattgg gaaataaact     1560

gtctagggat ctcagagcct ttaggacaga ttatctccac atctttgaaa aactaagaat     1620

ctgtgtgatg gtgttggtgg agtccctgga tgatgggata gggactttgg aggctcattt     1680

gaagaagatg ctaaaacaat cctatggctg gagggatagt tggggctgta gttggagatt     1740

ttcagttttt agaataaaag tattagttgt ggaatatact tcaggaccac ctctgtgaca     1800

gcatttatac agtatccgat gcatagggac aaagagtgga gtggggcact ttctttagat     1860

ttgtgaggaa tgttccgcac tagattgttt aaaacttcat ttgttggaag gagagctgtc     1920

ttagtgattg agtcaaggga gaaaggcatc tagcctcggt ctcaaaaggg tagttgctgt     1980

ctagagaggt ctggtggagc ctgcaaaagt ccagctttca aaggaacaca gaagtatgtg     2040

tatggaatat tagaagatgt tgcttttact cttaagttgg ttcctaggaa aaatagttaa     2100

atactgtgac tttaaaatgt gagagggttt tcaagtactc atttttttaa atgtccaaaa     2160

ttcttgtcaa tcagtttgag gtcttgtttg tgtagaactg atattactta aagtttaacc     2220

gaggaatggg agtgaggctc tctcataacc tattcagaac tgacttttaa caataataaa     2280

ttaagtttca aatattttta aatgaattga gcaatgttga gttggagtca agatggcctc     2340

gagatga                                                               2347


<210>  39
<211>  2910
<212>  DNA
<213>  artificial sequence

<220>
<223>  gBlock sequence

<400>  39
gcatagctag cgctcttcag taagaatggc ctctccaggt ctttattttt aacctttgtt       60

atggagtttt ctgagcattg cagactaatc ttggatattt gtccctgagg gagccggctg      120

agagaagtta agagtagcaa caaggaaata gcagggtgta gagggatctc ctgtctgaca      180

ggaggcaaga agacagattc ttacccctcc atttctcttt tatccctctc tggtcctcag      240

agagttagaa cttgtttatt gcagcttata atggttacaa ataaagcaat agcatcacaa      300

atttcacaaa taaagcattt ttttcactgc attctagttg tggtttgtcc aaactcatca      360

atgtatctta tcatgtctgg tcgacagtat gcagagggct gtatccactg gagaggatga      420

agtcactgag ttggaaaaca gaacaggaca ggcacctaac aagtggttgc tatagcccac      480

tgttaccctt ttacatgtat aggctcagga taagcagtga tactgtgagg tttatgtgtg      540

agaacatcac agtataaaca catctcaata gaggtcttag agatcagcac aattagtgag      600

aagtcataaa cagtagatac tataaggcat aggctcagct acctagggtc aggtatctgt      660

gtaaatctga ttgtgtatca ggtttagatc aatatgactt agggaggcga gtcatatgca      720

aatctaagaa gactttagag aagaaatctg aggctcacct cacataacag caagagagtg      780

tccggttagt ctcaaggaag actgagacac agtcttagat atcaccatgg gatggtcatg      840

tatcatcctt tttctagtag caactgcaac cggtgtacat tcttcctatg tgcgcccgct      900

gtcagtggcc ctgggggaga cggccaggat ttcctgtgga cgacaggccc ttggaagtag      960

agctgttcag tggtatcaac ataggccagg ccaggcccct atattgctca tttataataa     1020

tcaagaccgg ccctcaggga tccctgagcg attctctggc acccctgata ttaattttgg     1080

gaccagggcc accctgacca tcagcggggt cgaagccggg gatgaagccg actattactg     1140

tcacatgtgg gatagtagaa gtggcttcag ttggtctttc ggcggggcga ccaggctgac     1200

cgtcctacgg gctgatgctg caccaactgt atccatcttc tcaccatcca gtgagcagtt     1260

aacatctgga ggtgcttcag tcgtgtgctt cttgaacaac ttctacccca aagacatcaa     1320

tgtcaagtgg aagattgatg gcagtgaacg acaaaatggc gtcctgaaca gttggactga     1380

tcaggacagc aaagacagca cctacagcat gagcagcacc ctcacgttga ccaaggacga     1440

gtatgaacga cataacagct atacctgtga ggccactcac aagacatcaa cttcacccat     1500

tgtcaagagc ttcaacagga atgagtgtag gcggaagcgg gggtcaggag caaccaactt     1560

ttctctgctg aagcaagccg gggacgtaga ggaaaacccc ggacccatgg gatggtcatg     1620

tatcatcctt tttctagtag caactgcaac cggtgtacat tctcaggtgc agctgcagga     1680

gtcgggccca ggactggtga aaccttcgga gaccctgtcc gtcacctgca gtgtctctgg     1740

agattccatg aataattact actggacttg gatccggcag tcccccggaa agggactgga     1800

gtggataggc tatatctctg acagagaatc agcgacttac aacccctccc tcaatagtcg     1860

agtcgtcata tcacgagaca cgtcgaaaaa ccaattgtcc ctaaaattaa actccgtcac     1920

ccctgcggac acggccgtct attactgtgc gacagcgcgc cgaggacaga ggatttatgg     1980

agtggtttcc tttggagagt tcttctacta ctactccatg gacgtctggg gcaaggggac     2040

cacggtcacc gtctcctcag gtaagctggc ttttttcttt ctgcacattc cattctgaaa     2100

cgggatcgat tgggaaataa actgtctagg gatctcagag cctttaggac agattatctc     2160

cacatctttg aaaaactaag aatctgtgtg atggtgttgg tggagtccct ggatgatggg     2220

atagggactt tggaggctca tttgaagaag atgctaaaac aatcctatgg ctggagggat     2280

agttggggct gtagttggag attttcagtt tttagaataa aagtattagt tgtggaatat     2340

acttcaggac cacctctgtg acagcattta tacagtatcc gatgcatagg gacaaagagt     2400

ggagtggggc actttcttta gatttgtgag gaatgttccg cactagattg tttaaaactt     2460

catttgttgg aaggagagct gtcttagtga ttgagtcaag ggagaaaggc atctagcctc     2520

ggtctcaaaa gggtagttgc tgtctagaga ggtctggtgg agcctgcaaa agtccagctt     2580

tcaaaggaac acagaagtat gtgtatggaa tattagaaga tgttgctttt actcttaagt     2640

tggttcctag gaaaaatagt taaatactgt gactttaaaa tgtgagaggg ttttcaagta     2700

ctcatttttt taaatgtcca aaattcttgt caatcagttt gaggtcttgt ttgtgtagaa     2760

ctgatattac ttaaagttta accgaggaat gggagtgagg ctctctcata acctattcag     2820

aactgacttt taacaataat aaattaagtt tcaaatattt ttaaatgaat tgagcaatgt     2880

tgagttggag tcaagatggc ctcgaggaat                                      2910


<210>  40
<211>  2856
<212>  DNA
<213>  artificial sequence

<220>
<223>  gBlock sequence

<400>  40
gcatagctag cgctcttcag taagaatggc ctctccaggt ctttattttt aacctttgtt       60

atggagtttt ctgagcattg cagactaatc ttggatattt gtccctgagg gagccggctg      120

agagaagtta agagtagcaa caaggaaata gcagggtgta gagggatctc ctgtctgaca      180

ggaggcaaga agacagattc ttacccctcc atttctcttt tatccctctc tggtcctcag      240

agagttagaa cttgtttatt gcagcttata atggttacaa ataaagcaat agcatcacaa      300

atttcacaaa taaagcattt ttttcactgc attctagttg tggtttgtcc aaactcatca      360

atgtatctta tcatgtctgg tcgacagtat gcagagggct gtatccactg gagaggatga      420

agtcactgag ttggaaaaca gaacaggaca ggcacctaac aagtggttgc tatagcccac      480

tgttaccctt ttacatgtat aggctcagga taagcagtga tactgtgagg tttatgtgtg      540

agaacatcac agtataaaca catctcaata gaggtcttag agatcagcac aattagtgag      600

aagtcataaa cagtagatac tataaggcat aggctcagct acctagggtc aggtatctgt      660

gtaaatctga ttgtgtatca ggtttagatc aatatgactt agggaggcga gtcatatgca      720

aatctaagaa gactttagag aagaaatctg aggctcacct cacataacag caagagagtg      780

tccggttagt ctcaaggaag actgagacac agtcttagat atcaccatgg gatggtcatg      840

tatcatcctt tttctagtag caactgcaac cggtgtacat tctgacatcc agatgaccca      900

gtctccatcc tccctgtctg cctctgtggg agataccgtc actatcactt gccaggcaaa      960

cggctactta aattggtatc aacagaggcg agggaaagcc ccaaaactcc tgatctacga     1020

tgggtccaaa ttggaaagag gggtcccatc aaggttcagt ggaagaagat gggggcaaga     1080

atataatctg accatcaaca atctgcagcc cgaagacatt gcaacatatt tttgtcaagt     1140

gtatgagttt gtcgtccctg ggaccagact ggatttgaaa cgggctgatg ctgcaccaac     1200

tgtatccatc ttctcaccat ccagtgagca gttaacatct ggaggtgctt cagtcgtgtg     1260

cttcttgaac aacttctacc ccaaagacat caatgtcaag tggaagattg atggcagtga     1320

acgacaaaat ggcgtcctga acagttggac tgatcaggac agcaaagaca gcacctacag     1380

catgagcagc accctcacgt tgaccaagga cgagtatgaa cgacataaca gctatacctg     1440

tgaggccact cacaagacat caacttcacc cattgtcaag agcttcaaca ggaatgagtg     1500

taggcggaag cgggggtcag gagcaaccaa cttttctctg ctgaagcaag ccggggacgt     1560

agaggaaaac cccggaccca tgggatggtc atgtatcatc ctttttctag tagcaactgc     1620

aaccggtgta cattctcagg tccaattgtt acagtctggg gcagcggtga cgaagcccgg     1680

ggcctcagtg agagtctcct gcgaggcttc tggatacaac attcgtgact actttattca     1740

ttggtggcga caggccccag gacagggcct tcagtgggtg ggatggatca atcctaagac     1800

aggtcagcca aacaatcctc gtcaatttca gggtagagtc agtctgactc gacacgcgtc     1860

gtgggacttt gacacatttt ccttttacat ggacctgaag gcactaagat cggacgacac     1920

ggccgtttat ttctgtgcgc gacagcgcag cgactattgg gatttcgacg tctggggcag     1980

tggaacccag gtcactgtct cgtcaggtaa gctggctttt ttctttctgc acattccatt     2040

ctgaaacggg atcgattggg aaataaactg tctagggatc tcagagcctt taggacagat     2100

tatctccaca tctttgaaaa actaagaatc tgtgtgatgg tgttggtgga gtccctggat     2160

gatgggatag ggactttgga ggctcatttg aagaagatgc taaaacaatc ctatggctgg     2220

agggatagtt ggggctgtag ttggagattt tcagttttta gaataaaagt attagttgtg     2280

gaatatactt caggaccacc tctgtgacag catttataca gtatccgatg catagggaca     2340

aagagtggag tggggcactt tctttagatt tgtgaggaat gttccgcact agattgttta     2400

aaacttcatt tgttggaagg agagctgtct tagtgattga gtcaagggag aaaggcatct     2460

agcctcggtc tcaaaagggt agttgctgtc tagagaggtc tggtggagcc tgcaaaagtc     2520

cagctttcaa aggaacacag aagtatgtgt atggaatatt agaagatgtt gcttttactc     2580

ttaagttggt tcctaggaaa aatagttaaa tactgtgact ttaaaatgtg agagggtttt     2640

caagtactca tttttttaaa tgtccaaaat tcttgtcaat cagtttgagg tcttgtttgt     2700

gtagaactga tattacttaa agtttaaccg aggaatggga gtgaggctct ctcataacct     2760

attcagaact gacttttaac aataataaat taagtttcaa atatttttaa atgaattgag     2820

caatgttgag ttggagtcaa gatggcctcg aggaat                               2856


<210>  41
<211>  2901
<212>  DNA
<213>  artificial sequence

<220>
<223>  gBlock sequence

<400>  41
gcatagctag cgctcttcag taagaatggc ctctccaggt ctttattttt aacctttgtt       60

atggagtttt ctgagcattg cagactaatc ttggatattt gtccctgagg gagccggctg      120

agagaagtta agagtagcaa caaggaaata gcagggtgta gagggatctc ctgtctgaca      180

ggaggcaaga agacagattc ttacccctcc atttctcttt tatccctctc tggtcctcag      240

agagttagaa cttgtttatt gcagcttata atggttacaa ataaagcaat agcatcacaa      300

atttcacaaa taaagcattt ttttcactgc attctagttg tggtttgtcc aaactcatca      360

atgtatctta tcatgtctgg tcgacagtat gcagagggct gtatccactg gagaggatga      420

agtcactgag ttggaaaaca gaacaggaca ggcacctaac aagtggttgc tatagcccac      480

tgttaccctt ttacatgtat aggctcagga taagcagtga tactgtgagg tttatgtgtg      540

agaacatcac agtataaaca catctcaata gaggtcttag agatcagcac aattagtgag      600

aagtcataaa cagtagatac tataaggcat aggctcagct acctagggtc aggtatctgt      660

gtaaatctga ttgtgtatca ggtttagatc aatatgactt agggaggcga gtcatatgca      720

aatctaagaa gactttagag aagaaatctg aggctcacct cacataacag caagagagtg      780

tccggttagt ctcaaggaag actgagacac agtcttagat atcaccatgg gatggtcatg      840

tatcatcctt tttctagtag caactgcaac cggtgtacat tcttccgata tatctgtggc      900

cccaggagag acggccagga tttcctgtgg ggaaaagagc cttggaagta gagctgtaca      960

atggtatcaa cacagggccg gccaggcccc ctctttaatc atatataata atcaggaccg     1020

gccctcaggg atccctgagc gattctctgg ctcccctgac tccccttttg ggaccacggc     1080

caccctgacc atcaccagtg tcgaagccgg ggatgaggcc gactattact gtcatatatg     1140

ggatagtaga gttcccacca aatgggtctt cggcggaggg accacgctga ccgtgttacg     1200

ggctgatgct gcaccaactg tatccatctt ctcaccatcc agtgagcagt taacatctgg     1260

aggtgcttca gtcgtgtgct tcttgaacaa cttctacccc aaagacatca atgtcaagtg     1320

gaagattgat ggcagtgaac gacaaaatgg cgtcctgaac agttggactg atcaggacag     1380

caaagacagc acctacagca tgagcagcac cctcacgttg accaaggacg agtatgaacg     1440

acataacagc tatacctgtg aggccactca caagacatca acttcaccca ttgtcaagag     1500

cttcaacagg aatgagtgta ggcggaagcg ggggtcagga gcaaccaact tttctctgct     1560

gaagcaagcc ggggacgtag aggaaaaccc cggacccatg ggatggtcat gtatcatcct     1620

ttttctagta gcaactgcaa ccggtgtaca ttctcagatg cagttacagg agtcgggccc     1680

cggactggtg aagccttcgg aaaccctgtc cctcacgtgc agtgtgtctg gtgcctccat     1740

aagtgacagt tactggagct ggatccggcg gtccccaggg aagggacttg agtggattgg     1800

gtatgtccac aaaagcggcg acacaaatta cagcccctcc ctcaagagtc gagtcaactt     1860

gtcgttagac acgtccaaaa atcaggtgtc cctgagcctt gtggccgcga ccgctgcgga     1920

ctcgggcaaa tattattgcg cgagaacact gcacgggagg agaatttatg gaatcgttgc     1980

cttcaatgag tggttcacct acttctacat ggacgtctgg ggcaatggga ctcaggtcac     2040

cgtctcctca ggtaagctgg cttttttctt tctgcacatt ccattctgaa acgggatcga     2100

ttgggaaata aactgtctag ggatctcaga gcctttagga cagattatct ccacatcttt     2160

gaaaaactaa gaatctgtgt gatggtgttg gtggagtccc tggatgatgg gatagggact     2220

ttggaggctc atttgaagaa gatgctaaaa caatcctatg gctggaggga tagttggggc     2280

tgtagttgga gattttcagt ttttagaata aaagtattag ttgtggaata tacttcagga     2340

ccacctctgt gacagcattt atacagtatc cgatgcatag ggacaaagag tggagtgggg     2400

cactttcttt agatttgtga ggaatgttcc gcactagatt gtttaaaact tcatttgttg     2460

gaaggagagc tgtcttagtg attgagtcaa gggagaaagg catctagcct cggtctcaaa     2520

agggtagttg ctgtctagag aggtctggtg gagcctgcaa aagtccagct ttcaaaggaa     2580

cacagaagta tgtgtatgga atattagaag atgttgcttt tactcttaag ttggttccta     2640

ggaaaaatag ttaaatactg tgactttaaa atgtgagagg gttttcaagt actcattttt     2700

ttaaatgtcc aaaattcttg tcaatcagtt tgaggtcttg tttgtgtaga actgatatta     2760

cttaaagttt aaccgaggaa tgggagtgag gctctctcat aacctattca gaactgactt     2820

ttaacaataa taaattaagt ttcaaatatt tttaaatgaa ttgagcaatg ttgagttgga     2880

gtcaagatgg cctcgaggaa t                                               2901


<210>  42
<211>  2702
<212>  DNA
<213>  artificial sequence

<220>
<223>  gBlock sequence

<400>  42
gcatagctag cgctcttcaa ccacggtcac cgtctcctca ggtaagaatg gccactctag       60

ggcctttgtt ttctgctact gcctgtgggg tttcctgagc attgcaggtt ggtcctcggg      120

gcatgttccg aggggacctg ggcggactgg ccaggagggg atgggcactg gggtgccttg      180

aggatctggg agcctctgac agcgggacgc aagtagtgag ggcactcaga acgccactca      240

gccccgacag gcagggcacg aggaggcagc tcctcaccct ccctttctct tttgtcctgc      300

gggtcctcag ggagttagaa cttgtttatt gcagcttata atggttacaa ataaagcaat      360

agcatcacaa atttcacaaa taaagcattt ttttcactgc attctagttg tggtttgtcc      420

aaactcatca atgtatctta tcatgtctgg taacgagtgg ccaccttttc agtgttacca      480

gtgagctctg agtgttccta atgggaccag gatgggtcta ggtgcctgct caatgtcaga      540

gacagcaatg gtcccacaaa aaacccaggt aatctttagg ccaataaaat gtgggttcac      600

agtgaggagt gcatcctggg gttggggttt gttctgcagc gggaagagtg ctgtgcacag      660

aaagcttaga aatggggcaa gagatgcttt tcctcaggca ggatttaggg cttggtctct      720

cagcatccca cacttgtaca gctgatgtgg catctgtgtt ttctttctca tcctagatca      780

ggctttgagc tgtgaaatac cctgcctcat gcatatgcaa ataacctgag gtcttctgag      840

ataaatatag atatattggt gccctgagag catcacataa caaccacatt cctcctctga      900

agaagcccct gggagcacag ctcatcacca tgggatggtc atgtatcatc ctttttctag      960

tagcaactgc aaccggtgta cattctgaca tccagatgac ccagtctcca tcctccctgt     1020

ctgcatctgt aggagacaga gtcaccatca cttgccaggc gagtcaggac attagcaact     1080

atttaaattg gtatcagcag aaaccaggga aagcccctaa gctcctgatc tacgatgcat     1140

ccaatttgga aacaggggtc ccatcaaggt tcagtggaag tggatctggg acagatttta     1200

ctttcaccat cagcagcctg cagcctgaag atattgcaac atattactgt caacagtatg     1260

agtttatcgg ccctgggacc aaagtggata tcaaacgaac tgtggctgca ccatctgtct     1320

tcatcttccc gccatctgat gagcagttga aatctggaac tgcctctgtt gtgtgcctgc     1380

tgaataactt ctatcccaga gaggccaaag tacagtggaa ggtggataac gctctccaaa     1440

gcggtaactc ccaggagagt gtcacagagc aggacagcaa ggacagcacc tacagcctca     1500

gcagcaccct gacgctgagc aaagcagact acgagaaaca caaagtctac gcctgcgaag     1560

tcacccatca gggcctgagc tcgcccgtca caaagagctt caacagggga gagtgtaggc     1620

ggaagcgggg gtcaggagca accaactttt ctctgctgaa gcaagccggg gacgtagagg     1680

aaaaccccgg acccatggga tggtcatgta tcatcctttt tctagtagca actgcaaccg     1740

gtgtacattc tcaggtccat ttgtcacagt ctggggcagc ggtgacgaag cccggggcct     1800

cagtgagagt ctcctgcgag gcttccggat acaagattag tgaccacttt attcattggt     1860

ggcgacaggc cccaggacag ggccttcagt gggtggggtg gatcaatcct aagactggtc     1920

agccaaacaa tcctcgtcaa tttcagggta gagtcagtct gactcgacag gcgtcgtggg     1980

actttgacac atattccttt tacatggacc tcaaggcagt aagatcggac gacacggcca     2040

tttatttctg tgcgcgacaa cgcagcgact tttgggattt cgacgtctgg ggcagcggca     2100

cgcaggtcac tgtctcgtca ggtgagtcct cacaacctct ctcctgcttt aactctgaag     2160

ggttttgctg ctggattttc cgatgccttt ggaaaatggg actcaggttg ggtgcgtctg     2220

atggagtaac tgagcctggg ggcttgggga gccacatttg gacgagatgc ctgaacaaac     2280

caggggtctt agtgatggct gaggaatgtg tctcaggagc ggtgtctgta ggactgcaag     2340

atcgctgcac agcagcgaat cgtgaaatat tttctttaga attatgaggt gcgctgtgtg     2400

tcaacctgca tcttaaattc tttattggct ggaaagagaa ctgtcggagt gggtgaatcc     2460

agccaggagg gacgcgtagc cccggtcttg atgagagcag ggttgggggc aggggtagcc     2520

cagaaacggt ggctgccgtc ctgacagggg cttagggagg ctccaggacc tcagtgcctt     2580

gaagctggtt tccatgagaa aaggattgtt tatcttagga ggcatgctta ctgttaaaag     2640

acaggatatg tttgaagtgg cttctgagaa aaatggttaa gaaaattatg actcgaggaa     2700

tt                                                                    2702


<210>  43
<211>  2744
<212>  DNA
<213>  artificial sequence

<220>
<223>  gBlock sequence

<400>  43
gcatagctag cgctcttcaa ccacggtcac cgtctcctca ggtaagaatg gccactctag       60

ggcctttgtt ttctgctact gcctgtgggg tttcctgagc attgcaggtt ggtcctcggg      120

gcatgttccg aggggacctg ggcggactgg ccaggagggg atgggcactg gggtgccttg      180

aggatctggg agcctctgac agcgggacgc aagtagtgag ggcactcaga acgccactca      240

gccccgacag gcagggcacg aggaggcagc tcctcaccct ccctttctct tttgtcctgc      300

gggtcctcag ggagttagaa cttgtttatt gcagcttata atggttacaa ataaagcaat      360

agcatcacaa atttcacaaa taaagcattt ttttcactgc attctagttg tggtttgtcc      420

aaactcatca atgtatctta tcatgtctgg taacgagtgg ccaccttttc agtgttacca      480

gtgagctctg agtgttccta atgggaccag gatgggtcta ggtgcctgct caatgtcaga      540

gacagcaatg gtcccacaaa aaacccaggt aatctttagg ccaataaaat gtgggttcac      600

agtgaggagt gcatcctggg gttggggttt gttctgcagc gggaagagtg ctgtgcacag      660

aaagcttaga aatggggcaa gagatgcttt tcctcaggca ggatttaggg cttggtctct      720

cagcatccca cacttgtaca gctgatgtgg catctgtgtt ttctttctca tcctagatca      780

ggctttgagc tgtgaaatac cctgcctcat gcatatgcaa ataacctgag gtcttctgag      840

ataaatatag atatattggt gccctgagag catcacataa caaccacatt cctcctctga      900

agaagcccct gggagcacag ctcatcacca tgggatggtc atgtatcatc ctttttctag      960

tagcaactgc aaccggtgta cattcttcct atgtgcgccc gctgtcagtg gccctggggg     1020

agacggccag gatttcctgt ggacgacagg cccttggaag tagagctgtt cagtggtatc     1080

aacataggcc aggccaggcc cctatattgc tcatttataa taatcaagac cggccctcag     1140

ggatccctga gcgattctct ggcacccctg atattaattt tgggaccagg gccaccctga     1200

ccatcagcgg ggtcgaagcc ggggatgaag ccgactatta ctgtcacatg tgggatagta     1260

gaagtggctt cagttggtct ttcggcgggg cgaccaggct gaccgtccta cgaactgtgg     1320

ctgcaccatc tgtcttcatc ttcccgccat ctgatgagca gttgaaatct ggaactgcct     1380

ctgttgtgtg cctgctgaat aacttctatc ccagagaggc caaagtacag tggaaggtgg     1440

ataacgctct ccaaagcggt aactcccagg agagtgtcac agagcaggac agcaaggaca     1500

gcacctacag cctcagcagc accctgacgc tgagcaaagc agactacgag aaacacaaag     1560

tctacgcctg cgaagtcacc catcagggcc tgagctcgcc cgtcacaaag agcttcaaca     1620

ggggagagtg taggcggaag cgggggtcag gagcaaccaa cttttctctg ctgaagcaag     1680

ccggggacgt agaggaaaac cccggaccca tgggatggtc atgtatcatc ctttttctag     1740

tagcaactgc aaccggtgta cattctcagg tgcagctgca ggagtcgggc ccaggactgg     1800

tgaaaccttc ggagaccctg tccgtcacct gcagtgtctc tggagattcc atgaataatt     1860

actactggac ttggatccgg cagtcccccg gaaagggact ggagtggata ggctatatct     1920

ctgacagaga atcagcgact tacaacccct ccctcaatag tcgagtcgtc atatcacgag     1980

acacgtcgaa aaaccaattg tccctaaaat taaactccgt cacccctgcg gacacggccg     2040

tctattactg tgcgacagcg cgccgaggac agaggattta tggagtggtt tcctttggag     2100

agttcttcta ctactactcc atggacgtct ggggcaaggg gaccacggtc accgtctcct     2160

caggtgagtc ctcacaacct ctctcctgct ttaactctga agggttttgc tgctggattt     2220

tccgatgcct ttggaaaatg ggactcaggt tgggtgcgtc tgatggagta actgagcctg     2280

ggggcttggg gagccacatt tggacgagat gcctgaacaa accaggggtc ttagtgatgg     2340

ctgaggaatg tgtctcagga gcggtgtctg taggactgca agatcgctgc acagcagcga     2400

atcgtgaaat attttcttta gaattatgag gtgcgctgtg tgtcaacctg catcttaaat     2460

tctttattgg ctggaaagag aactgtcgga gtgggtgaat ccagccagga gggacgcgta     2520

gccccggtct tgatgagagc agggttgggg gcaggggtag cccagaaacg gtggctgccg     2580

tcctgacagg ggcttaggga ggctccagga cctcagtgcc ttgaagctgg tttccatgag     2640

aaaaggattg tttatcttag gaggcatgct tactgttaaa agacaggata tgtttgaagt     2700

ggcttctgag aaaaatggtt aagaaaatta tgactcgagg aatt                      2744


<210>  44
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer

<400>  44
cctggcccca ttgttcctta                                                   20


<210>  45
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer

<400>  45
gcgtctcagg acctttgtct                                                   20


<210>  46
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer

<400>  46
aatgtctgag ttgcccaggg                                                   20


<210>  47
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer

<400>  47
tgtcacagag gtggtcctga                                                   20


<210>  48
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer

<400>  48
atggctgcaa agagctccaa                                                   20


<210>  49
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer

<400>  49
ggaaaaaggg tcagaggcca                                                   20


<210>  50
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer

<400>  50
tgccctgtga ttatccgcaa                                                   20


<210>  51
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer

<400>  51
gagctggagg accgcaatag                                                   20


<210>  52
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer

<400>  52
gccactctag ggcctttgtt                                                   20


<210>  53
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer

<400>  53
agcttcaagg cactgaggtc                                                   20


<210>  54
<211>  19
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer

<400>  54
ctacatggac gtctggggc                                                    19


<210>  55
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer

<400>  55
ctgctctcat caagaccggg                                                   20


<210>  56
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  nuclear localization added to protein

<400>  56

Arg Arg Lys Arg 
1               


