                               SEQUENCE LISTING

<110> AVIDITY BIOSCIENCES, INC.
 
<120> COMPOSITIONS AND METHODS OF TREATING FACIOSCAPULOHUMERAL
      MUSCULAR DYSTROPHY

<130> 45532-742.601

<140> PCT/US2021/022214
<141> 2021-03-12

<150> 63/066,655
<151> 2020-08-17

<150> 62/992,071
<151> 2020-03-19

<160> 410   

<170> PatentIn version 3.5

<210> 1
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 1
cgacaccctc ggacagcac                                                    19


<210> 2
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 2
acggcgacgg agactcgtt                                                    19


<210> 3
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 3
cggcgacgga gactcgttt                                                    19


<210> 4
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 4
ggcgacggag actcgtttg                                                    19


<210> 5
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 5
gcgacggaga ctcgtttgg                                                    19


<210> 6
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 6
cgacggagac tcgtttgga                                                    19


<210> 7
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 7
gacggagact cgtttggac                                                    19


<210> 8
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 8
acggagactc gtttggacc                                                    19


<210> 9
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 9
ggaccccgag ccaaagcga                                                    19


<210> 10
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 10
gaccccgagc caaagcgag                                                    19


<210> 11
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 11
accccgagcc aaagcgagg                                                    19


<210> 12
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 12
cctgcgagcc tgctttgag                                                    19


<210> 13
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 13
gcgagcctgc tttgagcgg                                                    19


<210> 14
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 14
tcgccaccag agaacggct                                                    19


<210> 15
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 15
caggccatcg gcattccgg                                                    19


<210> 16
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 16
ggccatcggc attccggag                                                    19


<210> 17
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 17
gccatcggca ttccggagc                                                    19


<210> 18
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 18
gcaccggcgg gaatctcgg                                                    19


<210> 19
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 19
caccggcggg aatctcggc                                                    19


<210> 20
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 20
ccagaaggcc ggcgaaagc                                                    19


<210> 21
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 21
agaaggccgg cgaaagcgg                                                    19


<210> 22
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 22
gaaggccggc gaaagcgga                                                    19


<210> 23
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 23
gcgaaagcgg accgccgtc                                                    19


<210> 24
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 24
gaaagcggac cgccgtcac                                                    19


<210> 25
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 25
cggaccgccg tcaccggat                                                    19


<210> 26
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 26
ggaccgccgt caccggatc                                                    19


<210> 27
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 27
gaccgccgtc accggatcc                                                    19


<210> 28
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 28
agacgggcct cccggagtc                                                    19


<210> 29
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 29
cctcgtgggt cgccttcgc                                                    19


<210> 30
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 30
ctcgtgggtc gccttcgcc                                                    19


<210> 31
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 31
gaggggatct cccaacctg                                                    19


<210> 32
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 32
cgcgcgggga tttcgccta                                                    19


<210> 33
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 33
gcgcggggat ttcgcctac                                                    19


<210> 34
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 34
cggggatttc gcctacgcc                                                    19


<210> 35
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 35
tgcttgcgcc acccacgtc                                                    19


<210> 36
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 36
ctggcgagcc cggagtttc                                                    19


<210> 37
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 37
ggcgagcccg gagtttctg                                                    19


<210> 38
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 38
ggcgcaacct ctcctagaa                                                    19


<210> 39
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 39
gcgcaacctc tcctagaaa                                                    19


<210> 40
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 40
aacctctcct agaaacgga                                                    19


<210> 41
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 41
cagcgaggaa gaataccgg                                                    19


<210> 42
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 42
agcgaggaag aataccggg                                                    19


<210> 43
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 43
gcgaggaaga ataccgggc                                                    19


<210> 44
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 44
gttgggacgg ggtcgggtg                                                    19


<210> 45
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 45
acggggtcgg gtggttcgg                                                    19


<210> 46
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 46
ggtcgggtgg ttcggggca                                                    19


<210> 47
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 47
gtcgggtggt tcggggcag                                                    19


<210> 48
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 48
gcggtggcct ctctttcgc                                                    19


<210> 49
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 49
cggtggcctc tctttcgcg                                                    19


<210> 50
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 50
ggtggcctct ctttcgcgg                                                    19


<210> 51
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 51
gcctctcttt cgcggggaa                                                    19


<210> 52
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 52
cacctggctg gctacggag                                                    19


<210> 53
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 53
gctacggagg ggcgtgtct                                                    19


<210> 54
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 54
ctacggaggg gcgtgtctc                                                    19


<210> 55
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 55
acgtgcaagg gagctcgct                                                    19


<210> 56
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 56
cgtgcaaggg agctcgctg                                                    19


<210> 57
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 57
gtgcaaggga gctcgctgg                                                    19


<210> 58
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 58
caccttccga cgctgtcta                                                    19


<210> 59
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 59
accttccgac gctgtctag                                                    19


<210> 60
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 60
ccttccgacg ctgtctagg                                                    19


<210> 61
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 61
cttccgacgc tgtctaggc                                                    19


<210> 62
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 62
tccgacgctg tctaggcaa                                                    19


<210> 63
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 63
ccgacgctgt ctaggcaaa                                                    19


<210> 64
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 64
acgctgtcta ggcaaacct                                                    19


<210> 65
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 65
aaacctggat tagagttac                                                    19


<210> 66
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 66
ctttgagaag gatcgcttt                                                    19


<210> 67
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 67
gccggcagag gggatctcc                                                    19


<210> 68
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 68
gggccaaggg gtgcttgcg                                                    19


<210> 69
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 69
gccaaggggt gcttgcgcc                                                    19


<210> 70
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 70
atgcaaggca tcccggcgc                                                    19


<210> 71
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 71
gtgctgtccg agggtgtcg                                                    19


<210> 72
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 72
aacgagtctc cgtcgccgt                                                    19


<210> 73
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 73
aaacgagtct ccgtcgccg                                                    19


<210> 74
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 74
caaacgagtc tccgtcgcc                                                    19


<210> 75
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 75
ccaaacgagt ctccgtcgc                                                    19


<210> 76
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 76
tccaaacgag tctccgtcg                                                    19


<210> 77
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 77
gtccaaacga gtctccgtc                                                    19


<210> 78
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 78
ggtccaaacg agtctccgt                                                    19


<210> 79
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 79
tcgctttggc tcggggtcc                                                    19


<210> 80
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 80
ctcgctttgg ctcggggtc                                                    19


<210> 81
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 81
cctcgctttg gctcggggt                                                    19


<210> 82
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 82
ctcaaagcag gctcgcagg                                                    19


<210> 83
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 83
ccgctcaaag caggctcgc                                                    19


<210> 84
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 84
agccgttctc tggtggcga                                                    19


<210> 85
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 85
ccggaatgcc gatggcctg                                                    19


<210> 86
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 86
ctccggaatg ccgatggcc                                                    19


<210> 87
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 87
gctccggaat gccgatggc                                                    19


<210> 88
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 88
ccgagattcc cgccggtgc                                                    19


<210> 89
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 89
gccgagattc ccgccggtg                                                    19


<210> 90
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 90
gctttcgccg gccttctgg                                                    19


<210> 91
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 91
ccgctttcgc cggccttct                                                    19


<210> 92
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 92
tccgctttcg ccggccttc                                                    19


<210> 93
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 93
gacggcggtc cgctttcgc                                                    19


<210> 94
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 94
gtgacggcgg tccgctttc                                                    19


<210> 95
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 95
atccggtgac ggcggtccg                                                    19


<210> 96
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 96
gatccggtga cggcggtcc                                                    19


<210> 97
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 97
ggatccggtg acggcggtc                                                    19


<210> 98
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 98
gactccggga ggcccgtct                                                    19


<210> 99
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 99
gcgaaggcga cccacgagg                                                    19


<210> 100
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 100
ggcgaaggcg acccacgag                                                    19


<210> 101
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 101
caggttggga gatcccctc                                                    19


<210> 102
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 102
taggcgaaat ccccgcgcg                                                    19


<210> 103
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 103
gtaggcgaaa tccccgcgc                                                    19


<210> 104
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 104
ggcgtaggcg aaatccccg                                                    19


<210> 105
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 105
gacgtgggtg gcgcaagca                                                    19


<210> 106
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 106
gaaactccgg gctcgccag                                                    19


<210> 107
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 107
cagaaactcc gggctcgcc                                                    19


<210> 108
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 108
ttctaggaga ggttgcgcc                                                    19


<210> 109
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 109
tttctaggag aggttgcgc                                                    19


<210> 110
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 110
tccgtttcta ggagaggtt                                                    19


<210> 111
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 111
ccggtattct tcctcgctg                                                    19


<210> 112
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 112
cccggtattc ttcctcgct                                                    19


<210> 113
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 113
gcccggtatt cttcctcgc                                                    19


<210> 114
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 114
cacccgaccc cgtcccaac                                                    19


<210> 115
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 115
ccgaaccacc cgaccccgt                                                    19


<210> 116
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 116
tgccccgaac cacccgacc                                                    19


<210> 117
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 117
ctgccccgaa ccacccgac                                                    19


<210> 118
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 118
gcgaaagaga ggccaccgc                                                    19


<210> 119
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 119
cgcgaaagag aggccaccg                                                    19


<210> 120
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 120
ccgcgaaaga gaggccacc                                                    19


<210> 121
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 121
ttccccgcga aagagaggc                                                    19


<210> 122
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 122
ctccgtagcc agccaggtg                                                    19


<210> 123
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 123
agacacgccc ctccgtagc                                                    19


<210> 124
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 124
gagacacgcc cctccgtag                                                    19


<210> 125
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 125
agcgagctcc cttgcacgt                                                    19


<210> 126
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 126
cagcgagctc ccttgcacg                                                    19


<210> 127
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 127
ccagcgagct cccttgcac                                                    19


<210> 128
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 128
tagacagcgt cggaaggtg                                                    19


<210> 129
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 129
ctagacagcg tcggaaggt                                                    19


<210> 130
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 130
cctagacagc gtcggaagg                                                    19


<210> 131
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 131
gcctagacag cgtcggaag                                                    19


<210> 132
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 132
ttgcctagac agcgtcgga                                                    19


<210> 133
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 133
tttgcctaga cagcgtcgg                                                    19


<210> 134
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 134
aggtttgcct agacagcgt                                                    19


<210> 135
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 135
gtaactctaa tccaggttt                                                    19


<210> 136
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 136
aaagcgatcc ttctcaaag                                                    19


<210> 137
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 137
ggagatcccc tctgccggc                                                    19


<210> 138
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 138
cgcaagcacc ccttggccc                                                    19


<210> 139
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 139
ggcgcaagca ccccttggc                                                    19


<210> 140
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 140
gcgccgggat gccttgcat                                                    19


<210> 141
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (1)..(2)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (2)..(3)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-F

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-F

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-F

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (17)..(18)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (18)..(19)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-Me

<400> 141
cgacacccuc ggacagcaa                                                    19


<210> 142
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (1)..(2)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (2)..(3)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-F

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-F

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-F

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (17)..(18)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (18)..(19)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-Me

<400> 142
acggcgacgg agacucgua                                                    19


<210> 143
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (1)..(2)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (2)..(3)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-F

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-F

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-F

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (17)..(18)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (18)..(19)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-Me

<400> 143
cggcgacgga gacucguua                                                    19


<210> 144
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (1)..(2)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (2)..(3)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-F

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-F

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-F

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (17)..(18)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (18)..(19)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-Me

<400> 144
ggcgacggag acucguuua                                                    19


<210> 145
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (1)..(2)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (2)..(3)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-F

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-F

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-F

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (17)..(18)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (18)..(19)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-Me

<400> 145
gcgacggaga cucguuuga                                                    19


<210> 146
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (1)..(2)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (2)..(3)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-F

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-F

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-F

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (17)..(18)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (18)..(19)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-Me

<400> 146
cgacggagac ucguuugga                                                    19


<210> 147
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (1)..(2)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (2)..(3)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-F

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-F

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-F

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (17)..(18)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (18)..(19)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-Me

<400> 147
gacggagacu cguuuggaa                                                    19


<210> 148
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (1)..(2)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (2)..(3)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-F

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-F

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-F

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (17)..(18)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (18)..(19)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-Me

<400> 148
acggagacuc guuuggaca                                                    19


<210> 149
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (1)..(2)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (2)..(3)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-F

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-F

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-F

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (17)..(18)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (18)..(19)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-Me

<400> 149
ggaccccgag ccaaagcga                                                    19


<210> 150
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (1)..(2)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (2)..(3)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-F

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-F

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-F

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (17)..(18)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (18)..(19)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-Me

<400> 150
gaccccgagc caaagcgaa                                                    19


<210> 151
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (1)..(2)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (2)..(3)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-F

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-F

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-F

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (17)..(18)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (18)..(19)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-Me

<400> 151
accccgagcc aaagcgaga                                                    19


<210> 152
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (1)..(2)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (2)..(3)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-F

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-F

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-F

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (17)..(18)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (18)..(19)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-Me

<400> 152
ccugcgagcc ugcuuugaa                                                    19


<210> 153
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (1)..(2)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (2)..(3)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-F

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-F

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-F

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (17)..(18)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (18)..(19)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-Me

<400> 153
gcgagccugc uuugagcga                                                    19


<210> 154
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (1)..(2)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (2)..(3)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-F

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-F

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-F

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (17)..(18)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (18)..(19)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-Me

<400> 154
ucgccaccag agaacggca                                                    19


<210> 155
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (1)..(2)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (2)..(3)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-F

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-F

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-F

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (17)..(18)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (18)..(19)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-Me

<400> 155
caggccaucg gcauuccga                                                    19


<210> 156
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (1)..(2)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (2)..(3)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-F

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-F

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-F

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (17)..(18)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (18)..(19)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-Me

<400> 156
ggccaucggc auuccggaa                                                    19


<210> 157
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (1)..(2)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (2)..(3)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-F

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-F

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-F

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (17)..(18)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (18)..(19)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-Me

<400> 157
gccaucggca uuccggaga                                                    19


<210> 158
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (1)..(2)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (2)..(3)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-F

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-F

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-F

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (17)..(18)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (18)..(19)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-Me

<400> 158
gcaccggcgg gaaucucga                                                    19


<210> 159
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (1)..(2)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (2)..(3)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-F

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-F

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-F

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (17)..(18)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (18)..(19)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-Me

<400> 159
caccggcggg aaucucgga                                                    19


<210> 160
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (1)..(2)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (2)..(3)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-F

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-F

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-F

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (17)..(18)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (18)..(19)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-Me

<400> 160
ccagaaggcc ggcgaaaga                                                    19


<210> 161
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (1)..(2)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (2)..(3)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-F

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-F

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-F

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (17)..(18)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (18)..(19)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-Me

<400> 161
agaaggccgg cgaaagcga                                                    19


<210> 162
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (1)..(2)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (2)..(3)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-F

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-F

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-F

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (17)..(18)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (18)..(19)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-Me

<400> 162
gaaggccggc gaaagcgga                                                    19


<210> 163
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (1)..(2)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (2)..(3)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-F

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-F

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-F

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (17)..(18)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (18)..(19)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-Me

<400> 163
gcgaaagcgg accgccgua                                                    19


<210> 164
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (1)..(2)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (2)..(3)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-F

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-F

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-F

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (17)..(18)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (18)..(19)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-Me

<400> 164
gaaagcggac cgccgucaa                                                    19


<210> 165
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (1)..(2)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (2)..(3)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-F

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-F

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-F

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (17)..(18)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (18)..(19)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-Me

<400> 165
cggaccgccg ucaccggaa                                                    19


<210> 166
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (1)..(2)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (2)..(3)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-F

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-F

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-F

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (17)..(18)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (18)..(19)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-Me

<400> 166
ggaccgccgu caccggaua                                                    19


<210> 167
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (1)..(2)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (2)..(3)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-F

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-F

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-F

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (17)..(18)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (18)..(19)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-Me

<400> 167
gaccgccguc accggauca                                                    19


<210> 168
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (1)..(2)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (2)..(3)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-F

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-F

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-F

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (17)..(18)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (18)..(19)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-Me

<400> 168
agacgggccu cccggagua                                                    19


<210> 169
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (1)..(2)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (2)..(3)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-F

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-F

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-F

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (17)..(18)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (18)..(19)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-Me

<400> 169
ccucgugggu cgccuucga                                                    19


<210> 170
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (1)..(2)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (2)..(3)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-F

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-F

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-F

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (17)..(18)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (18)..(19)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-Me

<400> 170
cucguggguc gccuucgca                                                    19


<210> 171
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (1)..(2)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (2)..(3)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-F

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-F

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-F

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (17)..(18)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (18)..(19)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-Me

<400> 171
gaggggaucu cccaaccua                                                    19


<210> 172
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (1)..(2)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (2)..(3)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-F

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-F

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-F

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (17)..(18)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (18)..(19)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-Me

<400> 172
cgcgcgggga uuucgccua                                                    19


<210> 173
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (1)..(2)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (2)..(3)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-F

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-F

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-F

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (17)..(18)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (18)..(19)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-Me

<400> 173
gcgcggggau uucgccuaa                                                    19


<210> 174
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (1)..(2)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (2)..(3)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-F

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-F

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-F

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (17)..(18)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (18)..(19)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-Me

<400> 174
cggggauuuc gccuacgca                                                    19


<210> 175
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (1)..(2)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (2)..(3)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-F

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-F

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-F

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (17)..(18)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (18)..(19)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-Me

<400> 175
ugcuugcgcc acccacgua                                                    19


<210> 176
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (1)..(2)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (2)..(3)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-F

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-F

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-F

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (17)..(18)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (18)..(19)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-Me

<400> 176
cuggcgagcc cggaguuua                                                    19


<210> 177
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (1)..(2)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (2)..(3)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-F

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-F

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-F

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (17)..(18)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (18)..(19)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-Me

<400> 177
ggcgagcccg gaguuucua                                                    19


<210> 178
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (1)..(2)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (2)..(3)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-F

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-F

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-F

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (17)..(18)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (18)..(19)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-Me

<400> 178
ggcgcaaccu cuccuagaa                                                    19


<210> 179
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (1)..(2)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (2)..(3)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-F

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-F

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-F

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (17)..(18)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (18)..(19)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-Me

<400> 179
gcgcaaccuc uccuagaaa                                                    19


<210> 180
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (1)..(2)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (2)..(3)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-F

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-F

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-F

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (17)..(18)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (18)..(19)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-Me

<400> 180
aaccucuccu agaaacgga                                                    19


<210> 181
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (1)..(2)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (2)..(3)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-F

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-F

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-F

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (17)..(18)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (18)..(19)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-Me

<400> 181
cagcgaggaa gaauaccga                                                    19


<210> 182
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (1)..(2)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (2)..(3)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-F

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-F

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-F

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (17)..(18)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (18)..(19)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-Me

<400> 182
agcgaggaag aauaccgga                                                    19


<210> 183
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (1)..(2)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (2)..(3)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-F

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-F

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-F

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (17)..(18)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (18)..(19)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-Me

<400> 183
gcgaggaaga auaccggga                                                    19


<210> 184
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (1)..(2)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (2)..(3)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-F

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-F

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-F

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (17)..(18)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (18)..(19)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-Me

<400> 184
guugggacgg ggucgggua                                                    19


<210> 185
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (1)..(2)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (2)..(3)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-F

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-F

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-F

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (17)..(18)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (18)..(19)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-Me

<400> 185
acggggucgg gugguucga                                                    19


<210> 186
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (1)..(2)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (2)..(3)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-F

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-F

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-F

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (17)..(18)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (18)..(19)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-Me

<400> 186
ggucgggugg uucggggca                                                    19


<210> 187
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (1)..(2)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (2)..(3)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-F

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-F

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-F

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (17)..(18)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (18)..(19)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-Me

<400> 187
gucggguggu ucggggcaa                                                    19


<210> 188
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (1)..(2)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (2)..(3)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-F

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-F

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-F

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (17)..(18)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (18)..(19)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-Me

<400> 188
gcgguggccu cucuuucga                                                    19


<210> 189
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (1)..(2)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (2)..(3)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-F

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-F

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-F

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (17)..(18)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (18)..(19)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-Me

<400> 189
cgguggccuc ucuuucgca                                                    19


<210> 190
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (1)..(2)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (2)..(3)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-F

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-F

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-F

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (17)..(18)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (18)..(19)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-Me

<400> 190
gguggccucu cuuucgcga                                                    19


<210> 191
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (1)..(2)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (2)..(3)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-F

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-F

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-F

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (17)..(18)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (18)..(19)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-Me

<400> 191
gccucucuuu cgcggggaa                                                    19


<210> 192
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (1)..(2)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (2)..(3)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-F

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-F

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-F

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (17)..(18)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (18)..(19)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-Me

<400> 192
caccuggcug gcuacggaa                                                    19


<210> 193
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (1)..(2)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (2)..(3)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-F

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-F

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-F

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (17)..(18)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (18)..(19)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-Me

<400> 193
gcuacggagg ggcguguca                                                    19


<210> 194
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (1)..(2)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (2)..(3)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-F

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-F

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-F

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (17)..(18)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (18)..(19)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-Me

<400> 194
cuacggaggg gcgugucua                                                    19


<210> 195
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (1)..(2)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (2)..(3)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-F

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-F

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-F

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (17)..(18)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (18)..(19)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-Me

<400> 195
acgugcaagg gagcucgca                                                    19


<210> 196
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (1)..(2)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (2)..(3)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-F

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-F

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-F

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (17)..(18)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (18)..(19)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-Me

<400> 196
cgugcaaggg agcucgcua                                                    19


<210> 197
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (1)..(2)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (2)..(3)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-F

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-F

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-F

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (17)..(18)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (18)..(19)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-Me

<400> 197
gugcaaggga gcucgcuga                                                    19


<210> 198
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (1)..(2)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (2)..(3)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-F

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-F

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-F

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (17)..(18)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (18)..(19)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-Me

<400> 198
caccuuccga cgcugucua                                                    19


<210> 199
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (1)..(2)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (2)..(3)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-F

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-F

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-F

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (17)..(18)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (18)..(19)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-Me

<400> 199
accuuccgac gcugucuaa                                                    19


<210> 200
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (1)..(2)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (2)..(3)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-F

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-F

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-F

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (17)..(18)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (18)..(19)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-Me

<400> 200
ccuuccgacg cugucuaga                                                    19


<210> 201
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (1)..(2)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (2)..(3)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-F

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-F

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-F

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (17)..(18)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (18)..(19)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-Me

<400> 201
cuuccgacgc ugucuagga                                                    19


<210> 202
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (1)..(2)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (2)..(3)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-F

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-F

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-F

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (17)..(18)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (18)..(19)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-Me

<400> 202
uccgacgcug ucuaggcaa                                                    19


<210> 203
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (1)..(2)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (2)..(3)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-F

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-F

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-F

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (17)..(18)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (18)..(19)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-Me

<400> 203
ccgacgcugu cuaggcaaa                                                    19


<210> 204
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (1)..(2)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (2)..(3)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-F

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-F

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-F

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (17)..(18)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (18)..(19)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-Me

<400> 204
acgcugucua ggcaaacca                                                    19


<210> 205
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (1)..(2)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (2)..(3)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-F

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-F

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-F

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (17)..(18)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (18)..(19)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-Me

<400> 205
aaaccuggau uagaguuaa                                                    19


<210> 206
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (1)..(2)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (2)..(3)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-F

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-F

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-F

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (17)..(18)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (18)..(19)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-Me

<400> 206
cuuugagaag gaucgcuua                                                    19


<210> 207
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (1)..(2)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (2)..(3)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-F

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-F

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-F

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (17)..(18)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (18)..(19)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-Me

<400> 207
gccggcagag gggaucuca                                                    19


<210> 208
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (1)..(2)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (2)..(3)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-F

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-F

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-F

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (17)..(18)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (18)..(19)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-Me

<400> 208
gggccaaggg gugcuugca                                                    19


<210> 209
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (1)..(2)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (2)..(3)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-F

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-F

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-F

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (17)..(18)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (18)..(19)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-Me

<400> 209
gccaaggggu gcuugcgca                                                    19


<210> 210
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (1)..(2)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (2)..(3)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-F

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-F

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-F

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (17)..(18)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (18)..(19)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-Me

<400> 210
augcaaggca ucccggcga                                                    19


<210> 211
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-F

<220>
<221> misc_feature
<222> (1)..(2)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-F

<220>
<221> misc_feature
<222> (2)..(3)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-F

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-F

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-F

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (19)..(20)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (20)..(21)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'-O-Me

<400> 211
uugcuguccg agggugucgu u                                                 21


<210> 212
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-F

<220>
<221> misc_feature
<222> (1)..(2)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-F

<220>
<221> misc_feature
<222> (2)..(3)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-F

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-F

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-F

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (19)..(20)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (20)..(21)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'-O-Me

<400> 212
uacgagucuc cgucgccguu u                                                 21


<210> 213
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-F

<220>
<221> misc_feature
<222> (1)..(2)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-F

<220>
<221> misc_feature
<222> (2)..(3)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-F

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-F

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-F

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (19)..(20)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (20)..(21)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'-O-Me

<400> 213
uaacgagucu ccgucgccgu u                                                 21


<210> 214
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-F

<220>
<221> misc_feature
<222> (1)..(2)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-F

<220>
<221> misc_feature
<222> (2)..(3)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-F

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-F

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-F

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (19)..(20)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (20)..(21)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'-O-Me

<400> 214
uaaacgaguc uccgucgccu u                                                 21


<210> 215
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-F

<220>
<221> misc_feature
<222> (1)..(2)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-F

<220>
<221> misc_feature
<222> (2)..(3)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-F

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-F

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-F

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (19)..(20)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (20)..(21)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'-O-Me

<400> 215
ucaaacgagu cuccgucgcu u                                                 21


<210> 216
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-F

<220>
<221> misc_feature
<222> (1)..(2)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-F

<220>
<221> misc_feature
<222> (2)..(3)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-F

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-F

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-F

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (19)..(20)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (20)..(21)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'-O-Me

<400> 216
uccaaacgag ucuccgucgu u                                                 21


<210> 217
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-F

<220>
<221> misc_feature
<222> (1)..(2)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-F

<220>
<221> misc_feature
<222> (2)..(3)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-F

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-F

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-F

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (19)..(20)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (20)..(21)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'-O-Me

<400> 217
uuccaaacga gucuccgucu u                                                 21


<210> 218
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-F

<220>
<221> misc_feature
<222> (1)..(2)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-F

<220>
<221> misc_feature
<222> (2)..(3)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-F

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-F

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-F

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (19)..(20)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (20)..(21)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'-O-Me

<400> 218
uguccaaacg agucuccguu u                                                 21


<210> 219
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-F

<220>
<221> misc_feature
<222> (1)..(2)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-F

<220>
<221> misc_feature
<222> (2)..(3)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-F

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-F

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-F

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (19)..(20)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (20)..(21)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'-O-Me

<400> 219
ucgcuuuggc ucgggguccu u                                                 21


<210> 220
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-F

<220>
<221> misc_feature
<222> (1)..(2)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-F

<220>
<221> misc_feature
<222> (2)..(3)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-F

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-F

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-F

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (19)..(20)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (20)..(21)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'-O-Me

<400> 220
uucgcuuugg cucggggucu u                                                 21


<210> 221
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-F

<220>
<221> misc_feature
<222> (1)..(2)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-F

<220>
<221> misc_feature
<222> (2)..(3)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-F

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-F

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-F

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (19)..(20)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (20)..(21)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'-O-Me

<400> 221
ucucgcuuug gcucgggguu u                                                 21


<210> 222
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-F

<220>
<221> misc_feature
<222> (1)..(2)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-F

<220>
<221> misc_feature
<222> (2)..(3)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-F

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-F

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-F

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (19)..(20)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (20)..(21)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'-O-Me

<400> 222
uucaaagcag gcucgcaggu u                                                 21


<210> 223
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-F

<220>
<221> misc_feature
<222> (1)..(2)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-F

<220>
<221> misc_feature
<222> (2)..(3)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-F

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-F

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-F

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (19)..(20)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (20)..(21)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'-O-Me

<400> 223
ucgcucaaag caggcucgcu u                                                 21


<210> 224
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-F

<220>
<221> misc_feature
<222> (1)..(2)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-F

<220>
<221> misc_feature
<222> (2)..(3)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-F

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-F

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-F

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (19)..(20)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (20)..(21)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'-O-Me

<400> 224
ugccguucuc ugguggcgau u                                                 21


<210> 225
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-F

<220>
<221> misc_feature
<222> (1)..(2)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-F

<220>
<221> misc_feature
<222> (2)..(3)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-F

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-F

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-F

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (19)..(20)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (20)..(21)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'-O-Me

<400> 225
ucggaaugcc gauggccugu u                                                 21


<210> 226
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-F

<220>
<221> misc_feature
<222> (1)..(2)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-F

<220>
<221> misc_feature
<222> (2)..(3)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-F

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-F

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-F

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (19)..(20)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (20)..(21)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'-O-Me

<400> 226
uuccggaaug ccgauggccu u                                                 21


<210> 227
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-F

<220>
<221> misc_feature
<222> (1)..(2)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-F

<220>
<221> misc_feature
<222> (2)..(3)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-F

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-F

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-F

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (19)..(20)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (20)..(21)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'-O-Me

<400> 227
ucuccggaau gccgauggcu u                                                 21


<210> 228
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-F

<220>
<221> misc_feature
<222> (1)..(2)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-F

<220>
<221> misc_feature
<222> (2)..(3)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-F

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-F

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-F

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (19)..(20)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (20)..(21)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'-O-Me

<400> 228
ucgagauucc cgccggugcu u                                                 21


<210> 229
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-F

<220>
<221> misc_feature
<222> (1)..(2)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-F

<220>
<221> misc_feature
<222> (2)..(3)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-F

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-F

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-F

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (19)..(20)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (20)..(21)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'-O-Me

<400> 229
uccgagauuc ccgccggugu u                                                 21


<210> 230
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-F

<220>
<221> misc_feature
<222> (1)..(2)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-F

<220>
<221> misc_feature
<222> (2)..(3)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-F

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-F

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-F

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (19)..(20)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (20)..(21)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'-O-Me

<400> 230
ucuuucgccg gccuucuggu u                                                 21


<210> 231
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-F

<220>
<221> misc_feature
<222> (1)..(2)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-F

<220>
<221> misc_feature
<222> (2)..(3)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-F

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-F

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-F

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (19)..(20)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (20)..(21)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'-O-Me

<400> 231
ucgcuuucgc cggccuucuu u                                                 21


<210> 232
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-F

<220>
<221> misc_feature
<222> (1)..(2)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-F

<220>
<221> misc_feature
<222> (2)..(3)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-F

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-F

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-F

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (19)..(20)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (20)..(21)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'-O-Me

<400> 232
uccgcuuucg ccggccuucu u                                                 21


<210> 233
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-F

<220>
<221> misc_feature
<222> (1)..(2)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-F

<220>
<221> misc_feature
<222> (2)..(3)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-F

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-F

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-F

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (19)..(20)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (20)..(21)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'-O-Me

<400> 233
uacggcgguc cgcuuucgcu u                                                 21


<210> 234
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-F

<220>
<221> misc_feature
<222> (1)..(2)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-F

<220>
<221> misc_feature
<222> (2)..(3)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-F

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-F

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-F

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (19)..(20)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (20)..(21)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'-O-Me

<400> 234
uugacggcgg uccgcuuucu u                                                 21


<210> 235
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-F

<220>
<221> misc_feature
<222> (1)..(2)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-F

<220>
<221> misc_feature
<222> (2)..(3)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-F

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-F

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-F

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (19)..(20)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (20)..(21)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'-O-Me

<400> 235
uuccggugac ggcgguccgu u                                                 21


<210> 236
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-F

<220>
<221> misc_feature
<222> (1)..(2)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-F

<220>
<221> misc_feature
<222> (2)..(3)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-F

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-F

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-F

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (19)..(20)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (20)..(21)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'-O-Me

<400> 236
uauccgguga cggcgguccu u                                                 21


<210> 237
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-F

<220>
<221> misc_feature
<222> (1)..(2)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-F

<220>
<221> misc_feature
<222> (2)..(3)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-F

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-F

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-F

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (19)..(20)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (20)..(21)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'-O-Me

<400> 237
ugauccggug acggcggucu u                                                 21


<210> 238
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-F

<220>
<221> misc_feature
<222> (1)..(2)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-F

<220>
<221> misc_feature
<222> (2)..(3)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-F

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-F

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-F

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (19)..(20)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (20)..(21)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'-O-Me

<400> 238
uacuccggga ggcccgucuu u                                                 21


<210> 239
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-F

<220>
<221> misc_feature
<222> (1)..(2)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-F

<220>
<221> misc_feature
<222> (2)..(3)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-F

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-F

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-F

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (19)..(20)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (20)..(21)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'-O-Me

<400> 239
ucgaaggcga cccacgaggu u                                                 21


<210> 240
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-F

<220>
<221> misc_feature
<222> (1)..(2)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-F

<220>
<221> misc_feature
<222> (2)..(3)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-F

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-F

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-F

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (19)..(20)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (20)..(21)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'-O-Me

<400> 240
ugcgaaggcg acccacgagu u                                                 21


<210> 241
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-F

<220>
<221> misc_feature
<222> (1)..(2)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-F

<220>
<221> misc_feature
<222> (2)..(3)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-F

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-F

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-F

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (19)..(20)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (20)..(21)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'-O-Me

<400> 241
uagguuggga gauccccucu u                                                 21


<210> 242
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-F

<220>
<221> misc_feature
<222> (1)..(2)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-F

<220>
<221> misc_feature
<222> (2)..(3)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-F

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-F

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-F

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (19)..(20)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (20)..(21)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'-O-Me

<400> 242
uaggcgaaau ccccgcgcgu u                                                 21


<210> 243
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-F

<220>
<221> misc_feature
<222> (1)..(2)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-F

<220>
<221> misc_feature
<222> (2)..(3)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-F

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-F

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-F

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (19)..(20)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (20)..(21)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'-O-Me

<400> 243
uuaggcgaaa uccccgcgcu u                                                 21


<210> 244
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-F

<220>
<221> misc_feature
<222> (1)..(2)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-F

<220>
<221> misc_feature
<222> (2)..(3)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-F

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-F

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-F

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (19)..(20)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (20)..(21)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'-O-Me

<400> 244
ugcguaggcg aaauccccgu u                                                 21


<210> 245
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-F

<220>
<221> misc_feature
<222> (1)..(2)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-F

<220>
<221> misc_feature
<222> (2)..(3)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-F

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-F

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-F

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (19)..(20)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (20)..(21)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'-O-Me

<400> 245
uacgugggug gcgcaagcau u                                                 21


<210> 246
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-F

<220>
<221> misc_feature
<222> (1)..(2)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-F

<220>
<221> misc_feature
<222> (2)..(3)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-F

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-F

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-F

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (19)..(20)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (20)..(21)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'-O-Me

<400> 246
uaaacuccgg gcucgccagu u                                                 21


<210> 247
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-F

<220>
<221> misc_feature
<222> (1)..(2)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-F

<220>
<221> misc_feature
<222> (2)..(3)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-F

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-F

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-F

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (19)..(20)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (20)..(21)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'-O-Me

<400> 247
uagaaacucc gggcucgccu u                                                 21


<210> 248
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-F

<220>
<221> misc_feature
<222> (1)..(2)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-F

<220>
<221> misc_feature
<222> (2)..(3)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-F

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-F

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-F

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (19)..(20)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (20)..(21)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'-O-Me

<400> 248
uucuaggaga gguugcgccu u                                                 21


<210> 249
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-F

<220>
<221> misc_feature
<222> (1)..(2)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-F

<220>
<221> misc_feature
<222> (2)..(3)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-F

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-F

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-F

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (19)..(20)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (20)..(21)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'-O-Me

<400> 249
uuucuaggag agguugcgcu u                                                 21


<210> 250
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-F

<220>
<221> misc_feature
<222> (1)..(2)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-F

<220>
<221> misc_feature
<222> (2)..(3)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-F

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-F

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-F

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (19)..(20)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (20)..(21)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'-O-Me

<400> 250
uccguuucua ggagagguuu u                                                 21


<210> 251
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-F

<220>
<221> misc_feature
<222> (1)..(2)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-F

<220>
<221> misc_feature
<222> (2)..(3)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-F

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-F

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-F

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (19)..(20)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (20)..(21)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'-O-Me

<400> 251
ucgguauucu uccucgcugu u                                                 21


<210> 252
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-F

<220>
<221> misc_feature
<222> (1)..(2)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-F

<220>
<221> misc_feature
<222> (2)..(3)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-F

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-F

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-F

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (19)..(20)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (20)..(21)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'-O-Me

<400> 252
uccgguauuc uuccucgcuu u                                                 21


<210> 253
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-F

<220>
<221> misc_feature
<222> (1)..(2)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-F

<220>
<221> misc_feature
<222> (2)..(3)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-F

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-F

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-F

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (19)..(20)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (20)..(21)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'-O-Me

<400> 253
ucccgguauu cuuccucgcu u                                                 21


<210> 254
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-F

<220>
<221> misc_feature
<222> (1)..(2)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-F

<220>
<221> misc_feature
<222> (2)..(3)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-F

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-F

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-F

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (19)..(20)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (20)..(21)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'-O-Me

<400> 254
uacccgaccc cgucccaacu u                                                 21


<210> 255
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-F

<220>
<221> misc_feature
<222> (1)..(2)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-F

<220>
<221> misc_feature
<222> (2)..(3)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-F

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-F

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-F

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (19)..(20)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (20)..(21)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'-O-Me

<400> 255
ucgaaccacc cgaccccguu u                                                 21


<210> 256
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-F

<220>
<221> misc_feature
<222> (1)..(2)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-F

<220>
<221> misc_feature
<222> (2)..(3)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-F

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-F

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-F

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (19)..(20)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (20)..(21)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'-O-Me

<400> 256
ugccccgaac cacccgaccu u                                                 21


<210> 257
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-F

<220>
<221> misc_feature
<222> (1)..(2)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-F

<220>
<221> misc_feature
<222> (2)..(3)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-F

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-F

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-F

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (19)..(20)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (20)..(21)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'-O-Me

<400> 257
uugccccgaa ccacccgacu u                                                 21


<210> 258
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-F

<220>
<221> misc_feature
<222> (1)..(2)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-F

<220>
<221> misc_feature
<222> (2)..(3)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-F

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-F

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-F

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (19)..(20)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (20)..(21)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'-O-Me

<400> 258
ucgaaagaga ggccaccgcu u                                                 21


<210> 259
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-F

<220>
<221> misc_feature
<222> (1)..(2)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-F

<220>
<221> misc_feature
<222> (2)..(3)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-F

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-F

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-F

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (19)..(20)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (20)..(21)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'-O-Me

<400> 259
ugcgaaagag aggccaccgu u                                                 21


<210> 260
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-F

<220>
<221> misc_feature
<222> (1)..(2)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-F

<220>
<221> misc_feature
<222> (2)..(3)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-F

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-F

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-F

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (19)..(20)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (20)..(21)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'-O-Me

<400> 260
ucgcgaaaga gaggccaccu u                                                 21


<210> 261
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-F

<220>
<221> misc_feature
<222> (1)..(2)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-F

<220>
<221> misc_feature
<222> (2)..(3)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-F

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-F

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-F

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (19)..(20)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (20)..(21)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'-O-Me

<400> 261
uuccccgcga aagagaggcu u                                                 21


<210> 262
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-F

<220>
<221> misc_feature
<222> (1)..(2)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-F

<220>
<221> misc_feature
<222> (2)..(3)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-F

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-F

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-F

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (19)..(20)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (20)..(21)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'-O-Me

<400> 262
uuccguagcc agccaggugu u                                                 21


<210> 263
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-F

<220>
<221> misc_feature
<222> (1)..(2)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-F

<220>
<221> misc_feature
<222> (2)..(3)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-F

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-F

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-F

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (19)..(20)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (20)..(21)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'-O-Me

<400> 263
ugacacgccc cuccguagcu u                                                 21


<210> 264
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-F

<220>
<221> misc_feature
<222> (1)..(2)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-F

<220>
<221> misc_feature
<222> (2)..(3)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-F

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-F

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-F

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (19)..(20)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (20)..(21)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'-O-Me

<400> 264
uagacacgcc ccuccguagu u                                                 21


<210> 265
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-F

<220>
<221> misc_feature
<222> (1)..(2)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-F

<220>
<221> misc_feature
<222> (2)..(3)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-F

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-F

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-F

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (19)..(20)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (20)..(21)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'-O-Me

<400> 265
ugcgagcucc cuugcacguu u                                                 21


<210> 266
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-F

<220>
<221> misc_feature
<222> (1)..(2)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-F

<220>
<221> misc_feature
<222> (2)..(3)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-F

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-F

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-F

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (19)..(20)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (20)..(21)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'-O-Me

<400> 266
uagcgagcuc ccuugcacgu u                                                 21


<210> 267
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-F

<220>
<221> misc_feature
<222> (1)..(2)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-F

<220>
<221> misc_feature
<222> (2)..(3)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-F

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-F

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-F

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (19)..(20)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (20)..(21)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'-O-Me

<400> 267
ucagcgagcu cccuugcacu u                                                 21


<210> 268
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-F

<220>
<221> misc_feature
<222> (1)..(2)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-F

<220>
<221> misc_feature
<222> (2)..(3)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-F

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-F

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-F

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (19)..(20)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (20)..(21)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'-O-Me

<400> 268
uagacagcgu cggaaggugu u                                                 21


<210> 269
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-F

<220>
<221> misc_feature
<222> (1)..(2)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-F

<220>
<221> misc_feature
<222> (2)..(3)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-F

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-F

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-F

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (19)..(20)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (20)..(21)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'-O-Me

<400> 269
uuagacagcg ucggaagguu u                                                 21


<210> 270
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-F

<220>
<221> misc_feature
<222> (1)..(2)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-F

<220>
<221> misc_feature
<222> (2)..(3)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-F

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-F

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-F

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (19)..(20)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (20)..(21)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'-O-Me

<400> 270
ucuagacagc gucggaaggu u                                                 21


<210> 271
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-F

<220>
<221> misc_feature
<222> (1)..(2)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-F

<220>
<221> misc_feature
<222> (2)..(3)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-F

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-F

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-F

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (19)..(20)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (20)..(21)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'-O-Me

<400> 271
uccuagacag cgucggaagu u                                                 21


<210> 272
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-F

<220>
<221> misc_feature
<222> (1)..(2)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-F

<220>
<221> misc_feature
<222> (2)..(3)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-F

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-F

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-F

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (19)..(20)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (20)..(21)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'-O-Me

<400> 272
uugccuagac agcgucggau u                                                 21


<210> 273
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-F

<220>
<221> misc_feature
<222> (1)..(2)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-F

<220>
<221> misc_feature
<222> (2)..(3)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-F

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-F

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-F

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (19)..(20)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (20)..(21)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'-O-Me

<400> 273
uuugccuaga cagcgucggu u                                                 21


<210> 274
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-F

<220>
<221> misc_feature
<222> (1)..(2)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-F

<220>
<221> misc_feature
<222> (2)..(3)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-F

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-F

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-F

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (19)..(20)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (20)..(21)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'-O-Me

<400> 274
ugguuugccu agacagcguu u                                                 21


<210> 275
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-F

<220>
<221> misc_feature
<222> (1)..(2)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-F

<220>
<221> misc_feature
<222> (2)..(3)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-F

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-F

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-F

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (19)..(20)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (20)..(21)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'-O-Me

<400> 275
uuaacucuaa uccagguuuu u                                                 21


<210> 276
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-F

<220>
<221> misc_feature
<222> (1)..(2)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-F

<220>
<221> misc_feature
<222> (2)..(3)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-F

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-F

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-F

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (19)..(20)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (20)..(21)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'-O-Me

<400> 276
uaagcgaucc uucucaaagu u                                                 21


<210> 277
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-F

<220>
<221> misc_feature
<222> (1)..(2)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-F

<220>
<221> misc_feature
<222> (2)..(3)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-F

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-F

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-F

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (19)..(20)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (20)..(21)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'-O-Me

<400> 277
ugagaucccc ucugccggcu u                                                 21


<210> 278
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-F

<220>
<221> misc_feature
<222> (1)..(2)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-F

<220>
<221> misc_feature
<222> (2)..(3)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-F

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-F

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-F

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (19)..(20)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (20)..(21)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'-O-Me

<400> 278
ugcaagcacc ccuuggcccu u                                                 21


<210> 279
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-F

<220>
<221> misc_feature
<222> (1)..(2)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-F

<220>
<221> misc_feature
<222> (2)..(3)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-F

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-F

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-F

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (19)..(20)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (20)..(21)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'-O-Me

<400> 279
ugcgcaagca ccccuuggcu u                                                 21


<210> 280
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-F

<220>
<221> misc_feature
<222> (1)..(2)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-F

<220>
<221> misc_feature
<222> (2)..(3)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-F

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-F

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-F

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-Me

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (19)..(20)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-O-Me

<220>
<221> misc_feature
<222> (20)..(21)
<223> phosphorothioate linkage

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'-O-Me

<400> 280
ucgccgggau gccuugcauu u                                                 21


<210> 281
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 281
Tyr Thr Phe Thr Asn Tyr Trp Met His 
1               5                   


<210> 282
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 282
Glu Ile Asn Pro Ile Asn Gly Arg Ser Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 283
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 283
Gly Thr Arg Ala Met His Tyr 
1               5           


<210> 284
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 284
Glu Ile Asn Pro Ile Asn Gly Arg Ser Asn Tyr Ala Glu Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 285
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 285
Glu Ile Asn Pro Ile Gln Gly Arg Ser Asn Tyr Ala Glu Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 286
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 286
Arg Thr Ser Glu Asn Ile Tyr Asn Asn Leu Ala 
1               5                   10      


<210> 287
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 287
Ala Ala Thr Asn Leu Ala Asp 
1               5           


<210> 288
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 288
Gln His Phe Trp Gly Thr Pro Leu Thr 
1               5                   


<210> 289
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 289
Ala Ala Thr Asn Leu Ala Glu 
1               5           


<210> 290
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 290
Gln His Phe Trp Gly Thr Pro Leu Thr Phe 
1               5                   10  


<210> 291
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 291
Arg Thr Ser Glu Asn Ile Tyr Ser Asn Leu Ala 
1               5                   10      


<210> 292
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 292
Ala Gly Thr Asn Leu Ala Asp 
1               5           


<210> 293
<211> 116
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 293
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Glu Ile Asn Pro Ile Asn Gly Arg Ser Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Leu Thr Val Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Thr Arg Ala Met His Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210> 294
<211> 116
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 294
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn Pro Ile Asn Gly Arg Ser Asn Tyr Ala Glu Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Leu Thr Val Asp Thr Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Thr Arg Ala Met His Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210> 295
<211> 116
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 295
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Glu Ile Asn Pro Ile Gln Gly Arg Ser Asn Tyr Ala Glu Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Leu Thr Val Asp Thr Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Thr Arg Ala Met His Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210> 296
<211> 116
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 296
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Glu Ile Asn Pro Ile Asn Gly Arg Ser Asn Tyr Ala Glu Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Leu Thr Val Asp Thr Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Thr Arg Ala Met His Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210> 297
<211> 116
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 297
Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn Pro Ile Asn Gly Arg Ser Asn Tyr Gly Glu Arg Phe 
    50                  55                  60                  


Lys Thr Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Thr Arg Ala Met His Tyr Trp Gly Gln Gly Thr Ser Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210> 298
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 298
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Thr Ser Glu Asn Ile Tyr Asn Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Thr Asn Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln His Phe Trp Gly Thr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210> 299
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 299
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Thr Ser Glu Asn Ile Tyr Asn Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Thr Asn Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln His Phe Trp Gly Thr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210> 300
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 300
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Thr Ser Glu Asn Ile Tyr Asn Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Thr Asn Leu Ala Glu Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln His Phe Trp Gly Thr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210> 301
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 301
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Thr Ser Glu Asn Ile Tyr Ser Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Gly Thr Asn Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Asn Tyr Tyr Cys Gln His Phe Trp Gly Thr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210> 302
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 302
Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Val Ser Val Gly 
1               5                   10                  15      


Glu Thr Val Thr Ile Thr Cys Arg Thr Ser Glu Asn Ile Tyr Asn Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Gln Gly Lys Ser Pro Gln Leu Leu Val 
        35                  40                  45              


Tyr Ala Ala Thr Asn Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gln Tyr Ser Leu Lys Ile Asn Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Gly Asn Tyr Tyr Cys Gln His Phe Trp Gly Thr Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105         


<210> 303
<211> 445
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 303
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Glu Ile Asn Pro Ile Asn Gly Arg Ser Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Leu Thr Val Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Thr Arg Ala Met His Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
    210                 215                 220                 


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
            260                 265                 270         


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445 


<210> 304
<211> 445
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 304
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Glu Ile Asn Pro Ile Asn Gly Arg Ser Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Leu Thr Val Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Thr Arg Ala Met His Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
    210                 215                 220                 


Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
            260                 265                 270         


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445 


<210> 305
<211> 445
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 305
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Glu Ile Asn Pro Ile Asn Gly Arg Ser Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Leu Thr Val Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Thr Arg Ala Met His Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
    210                 215                 220                 


Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
            260                 265                 270         


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Gly Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445 


<210> 306
<211> 445
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 306
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Glu Ile Asn Pro Ile Asn Gly Arg Ser Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Leu Thr Val Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Thr Arg Ala Met His Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
    210                 215                 220                 


Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
            260                 265                 270         


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Lys Ala Arg Pro Ala Pro Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445 


<210> 307
<211> 445
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 307
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Glu Ile Asn Pro Ile Asn Gly Arg Ser Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Leu Thr Val Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Thr Arg Ala Met His Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
    210                 215                 220                 


Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
            260                 265                 270         


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Lys Ala Leu Gly Ala Pro Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445 


<210> 308
<211> 445
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 308
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Glu Ile Asn Pro Ile Asn Gly Arg Ser Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Leu Thr Val Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Thr Arg Ala Met His Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
    210                 215                 220                 


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Ala Val Ser His Glu Asp Pro Glu Val 
            260                 265                 270         


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Tyr Gly Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445 


<210> 309
<211> 445
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 309
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn Pro Ile Asn Gly Arg Ser Asn Tyr Ala Glu Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Leu Thr Val Asp Thr Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Thr Arg Ala Met His Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
    210                 215                 220                 


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
            260                 265                 270         


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445 


<210> 310
<211> 445
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 310
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn Pro Ile Asn Gly Arg Ser Asn Tyr Ala Glu Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Leu Thr Val Asp Thr Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Thr Arg Ala Met His Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
    210                 215                 220                 


Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
            260                 265                 270         


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445 


<210> 311
<211> 445
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 311
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn Pro Ile Asn Gly Arg Ser Asn Tyr Ala Glu Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Leu Thr Val Asp Thr Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Thr Arg Ala Met His Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
    210                 215                 220                 


Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
            260                 265                 270         


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Gly Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445 


<210> 312
<211> 445
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 312
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn Pro Ile Asn Gly Arg Ser Asn Tyr Ala Glu Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Leu Thr Val Asp Thr Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Thr Arg Ala Met His Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
    210                 215                 220                 


Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
            260                 265                 270         


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Lys Ala Arg Pro Ala Pro Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445 


<210> 313
<211> 445
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 313
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn Pro Ile Asn Gly Arg Ser Asn Tyr Ala Glu Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Leu Thr Val Asp Thr Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Thr Arg Ala Met His Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
    210                 215                 220                 


Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
            260                 265                 270         


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Lys Ala Leu Gly Ala Pro Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445 


<210> 314
<211> 445
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 314
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn Pro Ile Asn Gly Arg Ser Asn Tyr Ala Glu Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Leu Thr Val Asp Thr Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Thr Arg Ala Met His Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
    210                 215                 220                 


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Ala Val Ser His Glu Asp Pro Glu Val 
            260                 265                 270         


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Tyr Gly Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445 


<210> 315
<211> 445
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 315
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Glu Ile Asn Pro Ile Gln Gly Arg Ser Asn Tyr Ala Glu Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Leu Thr Val Asp Thr Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Thr Arg Ala Met His Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
    210                 215                 220                 


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
            260                 265                 270         


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445 


<210> 316
<211> 445
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 316
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Glu Ile Asn Pro Ile Gln Gly Arg Ser Asn Tyr Ala Glu Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Leu Thr Val Asp Thr Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Thr Arg Ala Met His Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
    210                 215                 220                 


Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
            260                 265                 270         


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445 


<210> 317
<211> 445
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 317
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Glu Ile Asn Pro Ile Gln Gly Arg Ser Asn Tyr Ala Glu Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Leu Thr Val Asp Thr Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Thr Arg Ala Met His Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
    210                 215                 220                 


Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
            260                 265                 270         


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Gly Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445 


<210> 318
<211> 445
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 318
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Glu Ile Asn Pro Ile Gln Gly Arg Ser Asn Tyr Ala Glu Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Leu Thr Val Asp Thr Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Thr Arg Ala Met His Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
    210                 215                 220                 


Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
            260                 265                 270         


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Lys Ala Arg Pro Ala Pro Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445 


<210> 319
<211> 445
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 319
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Glu Ile Asn Pro Ile Gln Gly Arg Ser Asn Tyr Ala Glu Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Leu Thr Val Asp Thr Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Thr Arg Ala Met His Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
    210                 215                 220                 


Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
            260                 265                 270         


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Lys Ala Leu Gly Ala Pro Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445 


<210> 320
<211> 445
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 320
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Glu Ile Asn Pro Ile Gln Gly Arg Ser Asn Tyr Ala Glu Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Leu Thr Val Asp Thr Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Thr Arg Ala Met His Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
    210                 215                 220                 


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Ala Val Ser His Glu Asp Pro Glu Val 
            260                 265                 270         


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Tyr Gly Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445 


<210> 321
<211> 445
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 321
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Glu Ile Asn Pro Ile Asn Gly Arg Ser Asn Tyr Ala Glu Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Leu Thr Val Asp Thr Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Thr Arg Ala Met His Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
    210                 215                 220                 


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
            260                 265                 270         


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445 


<210> 322
<211> 445
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 322
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Glu Ile Asn Pro Ile Asn Gly Arg Ser Asn Tyr Ala Glu Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Leu Thr Val Asp Thr Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Thr Arg Ala Met His Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
    210                 215                 220                 


Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
            260                 265                 270         


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445 


<210> 323
<211> 445
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 323
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Glu Ile Asn Pro Ile Asn Gly Arg Ser Asn Tyr Ala Glu Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Leu Thr Val Asp Thr Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Thr Arg Ala Met His Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
    210                 215                 220                 


Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
            260                 265                 270         


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Gly Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445 


<210> 324
<211> 445
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 324
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Glu Ile Asn Pro Ile Asn Gly Arg Ser Asn Tyr Ala Glu Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Leu Thr Val Asp Thr Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Thr Arg Ala Met His Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
    210                 215                 220                 


Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
            260                 265                 270         


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Lys Ala Arg Pro Ala Pro Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445 


<210> 325
<211> 445
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 325
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Glu Ile Asn Pro Ile Asn Gly Arg Ser Asn Tyr Ala Glu Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Leu Thr Val Asp Thr Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Thr Arg Ala Met His Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
    210                 215                 220                 


Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
            260                 265                 270         


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Lys Ala Leu Gly Ala Pro Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445 


<210> 326
<211> 445
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 326
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Glu Ile Asn Pro Ile Asn Gly Arg Ser Asn Tyr Ala Glu Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Leu Thr Val Asp Thr Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Thr Arg Ala Met His Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
    210                 215                 220                 


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Ala Val Ser His Glu Asp Pro Glu Val 
            260                 265                 270         


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Tyr Gly Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445 


<210> 327
<211> 214
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 327
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Thr Ser Glu Asn Ile Tyr Asn Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Thr Asn Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln His Phe Trp Gly Thr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210> 328
<211> 214
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 328
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Thr Ser Glu Asn Ile Tyr Asn Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Thr Asn Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln His Phe Trp Gly Thr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210> 329
<211> 214
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 329
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Thr Ser Glu Asn Ile Tyr Asn Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Thr Asn Leu Ala Glu Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln His Phe Trp Gly Thr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210> 330
<211> 214
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 330
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Thr Ser Glu Asn Ile Tyr Ser Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Gly Thr Asn Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Asn Tyr Tyr Cys Gln His Phe Trp Gly Thr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210> 331
<211> 24
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      INF7 sequence

<400> 331
Cys Gly Ile Phe Gly Glu Ile Glu Glu Leu Ile Glu Glu Gly Leu Glu 
1               5                   10                  15      


Asn Leu Ile Asp Trp Gly Asn Ala 
            20                  


<210> 332
<211> 24
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      INF7 sequence

<400> 332
Gly Leu Phe Glu Ala Ile Glu Gly Phe Ile Glu Asn Gly Trp Glu Gly 
1               5                   10                  15      


Met Ile Asp Gly Trp Tyr Gly Cys 
            20                  


<210> 333
<211> 27
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      INF7 sequence

<400> 333
Gly Leu Phe Glu Ala Ile Glu Gly Phe Ile Glu Asn Gly Trp Glu Gly 
1               5                   10                  15      


Met Ile Trp Asp Tyr Gly Ser Gly Ser Cys Gly 
            20                  25          


<210> 334
<211> 23
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      INF7 sequence

<400> 334
Gly Leu Phe Glu Ala Ile Glu Gly Phe Ile Glu Asn Gly Trp Glu Gly 
1               5                   10                  15      


Met Ile Asp Gly Trp Tyr Gly 
            20              


<210> 335
<211> 27
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      INF7 sequence

<400> 335
Gly Leu Phe Glu Ala Ile Glu Gly Phe Ile Glu Asn Gly Trp Glu Gly 
1               5                   10                  15      


Met Ile Trp Asp Tyr Gly Ser Gly Ser Cys Lys 
            20                  25          


<210> 336
<211> 27
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      melittin sequence

<400> 336
Cys Leu Ile Gly Ala Ile Leu Lys Val Leu Ala Thr Gly Leu Pro Thr 
1               5                   10                  15      


Leu Ile Ser Trp Ile Lys Asn Lys Arg Lys Gln 
            20                  25          


<210> 337
<211> 26
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      melittin sequence

<400> 337
Gly Ile Gly Ala Val Leu Lys Val Leu Thr Thr Gly Leu Pro Ala Leu 
1               5                   10                  15      


Ile Ser Trp Ile Lys Arg Lys Arg Gln Gln 
            20                  25      


<210> 338
<211> 13
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      meucin sequence

<400> 338
Ile Phe Gly Ala Ile Ala Gly Leu Leu Lys Asn Ile Phe 
1               5                   10              


<210> 339
<211> 18
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      meucin sequence

<400> 339
Phe Phe Gly His Leu Phe Lys Leu Ala Thr Lys Ile Ile Pro Ser Leu 
1               5                   10                  15      


Phe Gln 
        


<210> 340
<211> 21
<212> PRT
<213> Simian virus 40

<400> 340
Lys Glu Thr Trp Trp Glu Thr Trp Trp Thr Glu Trp Ser Gln Pro Lys 
1               5                   10                  15      


Lys Lys Arg Lys Val 
            20      


<210> 341
<211> 19
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      pVEC sequence

<400> 341
Leu Leu Ile Ile Leu Arg Arg Arg Arg Ile Arg Lys Gln Ala His Ala 
1               5                   10                  15      


His Ser Lys 
            


<210> 342
<211> 26
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 342
Asp Pro Lys Gly Asp Pro Lys Gly Val Thr Val Thr Val Thr Val Thr 
1               5                   10                  15      


Val Thr Gly Lys Gly Asp Pro Lys Pro Asp 
            20                  25      


<210> 343
<211> 17
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      C105Y sequence

<400> 343
Cys Ser Ile Pro Pro Glu Val Lys Phe Asn Lys Pro Phe Val Tyr Leu 
1               5                   10                  15      


Ile 
    


<210> 344
<211> 27
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 344
Gly Trp Thr Leu Asn Ser Ala Gly Tyr Leu Leu Gly Lys Ile Asn Leu 
1               5                   10                  15      


Lys Ala Leu Ala Ala Leu Ala Lys Lys Ile Leu 
            20                  25          


<210> 345
<211> 21
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      TP10 sequence

<400> 345
Ala Gly Tyr Leu Leu Gly Lys Ile Asn Leu Lys Ala Leu Ala Ala Leu 
1               5                   10                  15      


Ala Lys Lys Ile Leu 
            20      


<210> 346
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 346
Gly Ala Leu Phe Leu Gly Phe Leu Gly Ala Ala Gly Ser Thr Met Gly 
1               5                   10                  15      


Ala 
    


<210> 347
<211> 20
<212> PRT
<213> Herpes simplex virus

<400> 347
His Gly Leu Ala Ser Thr Leu Thr Arg Trp Ala His Tyr Asn Ala Leu 
1               5                   10                  15      


Ile Arg Ala Phe 
            20  


<210> 348
<211> 20
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      CADY sequence

<400> 348
Gly Leu Trp Arg Ala Leu Trp Arg Leu Leu Arg Ser Leu Trp Arg Leu 
1               5                   10                  15      


Leu Trp Arg Ala 
            20  


<210> 349
<211> 30
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 349
Trp Glu Ala Ala Leu Ala Glu Ala Leu Ala Glu Ala Leu Ala Glu His 
1               5                   10                  15      


Leu Ala Glu Ala Leu Ala Glu Ala Leu Glu Ala Leu Ala Ala 
            20                  25                  30  


<210> 350
<211> 24
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 350
Gly Leu Phe Glu Ala Ile Glu Gly Phe Ile Glu Asn Gly Trp Glu Gly 
1               5                   10                  15      


Met Ile Asp Gly Trp Tyr Gly Cys 
            20                  


<210> 351
<211> 23
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 351
Gly Leu Phe Gly Ala Ile Ala Gly Phe Ile Glu Asn Gly Trp Glu Gly 
1               5                   10                  15      


Met Ile Asp Gly Trp Tyr Gly 
            20              


<210> 352
<211> 36
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 352
Gly Leu Phe Gly Ala Ile Ala Gly Phe Ile Glu Asn Gly Trp Glu Gly 
1               5                   10                  15      


Met Ile Asp Gly Arg Gln Ile Lys Ile Trp Phe Gln Asn Arg Arg Met 
            20                  25                  30          


Lys Trp Lys Lys 
        35      


<210> 353
<211> 26
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 353
Gly Leu Phe Gly Ala Ile Ala Gly Phe Ile Glu Asn Gly Trp Glu Gly 
1               5                   10                  15      


Met Ile Asp Gly Ser Ser Lys Lys Lys Lys 
            20                  25      


<210> 354
<211> 24
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 354
Gly Leu Phe Glu Ala Ile Ala Gly Phe Ile Glu Asn Gly Trp Glu Gly 
1               5                   10                  15      


Met Ile Asp Gly Gly Gly Tyr Cys 
            20                  


<210> 355
<211> 23
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 355
Gly Leu Phe His Ala Ile Ala His Phe Ile His Gly Gly Trp His Gly 
1               5                   10                  15      


Leu Ile His Gly Trp Tyr Gly 
            20              


<210> 356
<211> 30
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 356
Gly Leu Phe Glu Ala Ile Glu Gly Phe Ile Glu Asn Gly Trp Glu Gly 
1               5                   10                  15      


Leu Ala Glu Ala Leu Ala Glu Ala Leu Glu Ala Leu Ala Ala 
            20                  25                  30  


<210> 357
<211> 29
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 357
Lys Trp Lys Leu Phe Lys Lys Ile Gly Ala Val Leu Lys Val Leu Thr 
1               5                   10                  15      


Thr Gly Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg 
            20                  25                  


<210> 358
<211> 16
<212> PRT
<213> Drosophila sp.

<400> 358
Arg Gln Ile Lys Ile Trp Phe Gln Asn Arg Arg Met Lys Trp Lys Lys 
1               5                   10                  15      


<210> 359
<211> 13
<212> PRT
<213> Human immunodeficiency virus

<400> 359
Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Pro Pro Gln 
1               5                   10              


<210> 360
<211> 18
<212> PRT
<213> Mus sp.

<400> 360
Leu Leu Ile Ile Leu Arg Arg Arg Ile Arg Lys Gln Ala His Ala His 
1               5                   10                  15      


Ser Lys 
        


<210> 361
<211> 27
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 361
Gly Trp Thr Leu Asn Ser Ala Gly Tyr Leu Leu Gly Lys Ile Asn Leu 
1               5                   10                  15      


Lys Ala Leu Ala Ala Leu Ala Lys Lys Ile Leu 
            20                  25          


<210> 362
<211> 27
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 362
Gly Ala Leu Phe Leu Gly Phe Leu Gly Ala Ala Gly Ser Thr Met Gly 
1               5                   10                  15      


Ala Trp Ser Gln Pro Lys Lys Lys Arg Lys Val 
            20                  25          


<210> 363
<211> 21
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 363
Lys Glu Thr Trp Trp Glu Thr Trp Trp Thr Glu Trp Ser Gln Pro Lys 
1               5                   10                  15      


Lys Lys Arg Lys Val 
            20      


<210> 364
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> SITE
<222> (1)..(12)
<223> This sequence may encompass 6-12 residues

<400> 364
Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg 
1               5                   10          


<210> 365
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 365
Lys Leu Ala Leu Lys Leu Ala Leu Lys Ala Leu Lys Ala Ala Leu Lys 
1               5                   10                  15      


Leu Ala 
        


<210> 366
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 366
Arg Arg Trp Trp Arg Arg Trp Arg Arg 
1               5                   


<210> 367
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 367
Cys Gly Tyr Gly Pro Lys Lys Lys Arg Lys Val Gly Gly 
1               5                   10              


<210> 368
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 368
Lys Lys Lys Lys Lys Lys Lys Lys 
1               5               


<210> 369
<211> 22
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 369
Met Val Arg Arg Phe Leu Val Thr Leu Arg Ile Arg Arg Ala Cys Gly 
1               5                   10                  15      


Pro Pro Arg Val Arg Val 
            20          


<210> 370
<211> 28
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 370
Leu Ser Thr Ala Ala Asp Met Gln Gly Val Val Thr Asp Gly Met Ala 
1               5                   10                  15      


Ser Gly Leu Asp Lys Asp Tyr Leu Lys Pro Asp Asp 
            20                  25              


<210> 371
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 371
ctgcctctcc accagccca                                                    19


<210> 372
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 372
tgggctggtg gagaggcag                                                    19


<210> 373
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 373
gcagagatgg agagaggaa                                                    19


<210> 374
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 374
ttcctctctc catctctgc                                                    19


<210> 375
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 375
gcggtttcct ccgggacaa                                                    19


<210> 376
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 376
ttgtcccgga ggaaaccgc                                                    19


<210> 377
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 377
ggacgacgga ggcgtgatt                                                    19


<210> 378
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 378
aatcacgcct ccgtcgtcc                                                    19


<210> 379
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 379
cgggcacccg gaaacatgca gggaa                                             25


<210> 380
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 380
ttccctgcat gtttccgggt gcccg                                             25


<210> 381
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 381
ccggaaacat gcagggaag                                                    19


<210> 382
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 382
cttccctgca tgtttccgg                                                    19


<210> 383
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 383
gaaatgaacg agagccaca                                                    19


<210> 384
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 384
tgtggctctc gttcatttc                                                    19


<210> 385
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 385
tggcacactc aagactccca cggag                                             25


<210> 386
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 386
ctccgtggga gtcttgagtg tgcca                                             25


<210> 387
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 387
ccacggaggt tcagttcca                                                    19


<210> 388
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 388
tggaactgaa cctccgtgg                                                    19


<210> 389
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 389
accaccacca ccaccacca                                                    19


<210> 390
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 390
tggtggtggt ggtggtggt                                                    19


<210> 391
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 391
cgccattcat gaaggggtg                                                    19


<210> 392
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 392
caccccttca tgaatggcg                                                    19


<210> 393
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 393
catgaagggg tggagcctg                                                    19


<210> 394
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 394
caggctccac cccttcatg                                                    19


<210> 395
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 395
gagcctgctt tgagcggaa                                                    19


<210> 396
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 396
ttccgctcaa agcaggctc                                                    19


<210> 397
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 397
ccgagccttt gagaaggatc gcttt                                             25


<210> 398
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 398
aaagcgatcc ttctcaaagg ctcgg                                             25


<210> 399
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 399
ggcagggcgc ccgcgcagg                                                    19


<210> 400
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 400
cctgcgcggg cgccctgcc                                                    19


<210> 401
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 401
gatgattagt tcagagata                                                    19


<210> 402
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 402
tatctctgaa ctaatcatc                                                    19


<210> 403
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (6)..(6)
<223> N or Q 

<220>
<221> MOD_RES
<222> (13)..(13)
<223> Q or E

<400> 403
Glu Ile Asn Pro Ile Xaa Gly Arg Ser Asn Tyr Ala Xaa Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 404
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (8)..(8)
<223> N or S

<400> 404
Arg Thr Ser Glu Asn Ile Tyr Xaa Asn Leu Ala 
1               5                   10      


<210> 405
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (2)..(2)
<223> A or G

<220>
<221> MOD_RES
<222> (7)..(7)
<223> D or E

<400> 405
Ala Xaa Thr Asn Leu Ala Xaa 
1               5           


<210> 406
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (10)..(10)
<223> F or absent

<400> 406
Gln His Phe Trp Gly Thr Pro Leu Thr Xaa 
1               5                   10  


<210> 407
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (7)..(7)
<223> D or E

<400> 407
Ala Ala Thr Asn Leu Ala Xaa 
1               5           


<210> 408
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 408
Gly Gly Phe Gly 
1               


<210> 409
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 409
Ala Leu Ala Leu 
1               


<210> 410
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 410
Gly Phe Leu Gly 
1               


