               SEQUENCE LISTING

<110> Xbrane Biopharma AB

<120> NOVEL COMBINATION OF TIS SEQUENCE AND SIGNAL PEPTIDE SEQUENCE FOR EXPRESSING A RECOMBINANT PROTEIN  

<130> 2020Q105-2

<160> 14

<170> BiSSAP 1.3.6

<210> 1
<211> 11
<212> DNA
<213> Artificial Sequence


<220> 
<223> Kozak sequence - DNA

<400> 1
tcggtcatgg c                                                         11


<210> 2
<211> 78
<212> DNA
<213> Artificial Sequence


<220> 
<223> Signal peptide - DNA sequence

<400> 2
atggctctgc tgcacaagaa catgaagcac ctgtggttct ttctgctgct ggtggccgct     60

cctagatggg tgctgtct                                                   78


<210> 3
<211> 26
<212> PRT
<213> Artificial Sequence


<220> 
<223> Signal peptide aa sequence

<400> 3
Met Ala Leu Leu His Lys Asn Met Lys His Leu Trp Phe Phe Leu Leu 
1               5                   10                  15      
Leu Val Ala Ala Pro Arg Trp Val Leu Ser 
            20                  25      

<210> 4
<211> 1326
<212> DNA
<213> Artificial Sequence


<220> 
<223> Nivolumab - heavy chain - DNA sequence

<400> 4
caggtgcagc tggttgaatc tggtggcgga gtggtgcagc ctggcagatc tctgagactg      60

gattgcaagg cctccggcat caccttctcc aactctggca tgcactgggt ccgacaggcc     120

cctggaaaag gactggaatg ggtcgccgtg atttggtacg acggctctaa gcggtactac     180

gccgactccg tgaagggcag attcaccatc tctcgggaca actccaagaa caccctgttt     240

ctgcagatga actccctgag agccgaggac accgccgtgt actactgtgc caccaacgat     300

gattattggg gccagggcac actggtcacc gtgtcctctg cttctaccaa gggaccctct     360

gtgttccctc tggctccttg ctccagatcc acctctgagt ctaccgctgc tctgggctgc     420

ctggtcaagg attactttcc tgagcctgtg accgtgtctt ggaactctgg tgctctgacc     480

tccggcgtgc acacatttcc agctgtgctg cagtcctccg gcctgtactc tctgtcctct     540

gtcgtgaccg tgccttctag ctctctgggc accaagacct acacctgtaa cgtggaccac     600

aagccttcca acaccaaggt ggacaagcgc gtggaatcta agtacggccc tccttgtcct     660

ccatgtcctg ctccagaatt cctcggcgga ccttccgtgt tcctgtttcc tccaaagcct     720

aaggacaccc tgatgatctc tcggacccct gaagtgacct gcgtggtggt ggatgtgtct     780

caagaggacc ccgaggtgca gttcaattgg tacgtggacg gcgtggaagt gcacaacgcc     840

aagaccaagc ctagagagga acagttcaac tccacctaca gagtggtgtc cgtgctgacc     900

gtgctgcacc aggattggct gaacggcaaa gagtacaagt gcaaggtgtc caacaagggc     960

ctgccttcca gcatcgaaaa gaccatctcc aaggctaagg gccagcctcg ggaacctcag    1020

gtttacaccc tgcctccaag ccaagaggaa atgaccaaga accaggtgtc cctgacctgc    1080

ctcgtgaagg gattctaccc ttccgatatc gccgtggaat gggagtccaa tggccagcct    1140

gagaacaact acaagacaac ccctcctgtg ctggactccg acggctcctt ctttctgtat    1200

tcccgcctga ccgtggacaa gtctagatgg caagagggca acgtgttctc ctgctctgtg    1260

atgcacgagg ccctgcacaa ccactacacc cagaagtccc tgtctctgtc cctgggcaaa    1320

tgatag                                                               1326


<210> 5
<211> 440
<212> PRT
<213> Artificial Sequence


<220> 
<223> Nivolumab - heavy chain - protein sequence

<400> 5
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      
Ser Leu Arg Leu Asp Cys Lys Ala Ser Gly Ile Thr Phe Ser Asn Ser 
            20                  25                  30          
Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ala Val Ile Trp Tyr Asp Gly Ser Lys Arg Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Phe 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Thr Asn Asp Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         
Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser 
        115                 120                 125             
Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
    130                 135                 140                 
Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
145                 150                 155                 160 
Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
                165                 170                 175     
Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys 
            180                 185                 190         
Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp 
        195                 200                 205             
Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala 
    210                 215                 220                 
Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
225                 230                 235                 240 
Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
                245                 250                 255     
Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val 
            260                 265                 270         
Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
        275                 280                 285             
Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
    290                 295                 300                 
Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly 
305                 310                 315                 320 
Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
                325                 330                 335     
Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr 
            340                 345                 350         
Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
        355                 360                 365             
Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
    370                 375                 380                 
Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
385                 390                 395                 400 
Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe 
                405                 410                 415     
Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
            420                 425                 430         
Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440 

<210> 6
<211> 648
<212> DNA
<213> Artificial Sequence


<220> 
<223> Nivolumab - light chain - DNA sequence

<400> 6
gagatcgtgc tgacccagtc tcctgccaca ttgtctctga gtcctggcga gagagctacc      60

ctgtcttgca gagcttccca gtccgtgtcc tcctacctgg cctggtatca gcagaaacct     120

ggacaggccc ctcggctgct gatctacgat gcctctaata gagccacagg catccccgcc     180

agattctctg gctctggatc tggcaccgac ttcaccctga ccatctctag cctggaacct     240

gaggacttcg ccgtgtacta ctgccagcag tcctccaact ggcctagaac ctttggccag     300

ggcaccaagg tggaaatcaa gagaaccgtg gctgcccctt ccgtgttcat cttcccacca     360

tctgacgagc agctgaagtc cggcacagct tctgtcgtgt gcctgctgaa caacttctac     420

cctcgggaag ccaaggtgca gtggaaggtg gacaatgccc tgcagtccgg caactcccaa     480

gagtctgtga ccgagcagga ctccaaggac tctacctaca gcctgtcctc cacactgacc     540

ctgtctaagg ccgactacga gaagcacaag gtgtacgcct gtgaagtgac ccaccaggga     600

ctgtctagcc ccgtgaccaa gtctttcaac agaggcgagt gctgatag                  648


<210> 7
<211> 214
<212> PRT
<213> Artificial Sequence


<220> 
<223> Nivolumab - light chain - protein sequence

<400> 7
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              
Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Ser Ser Asn Trp Pro Arg 
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             
Phe Asn Arg Gly Glu Cys 
    210                 

<210> 8
<211> 1410
<212> DNA
<213> Artificial Sequence


<220> 
<223> Kozak - SP - protein heavy chain - DNA

<400> 8
tcggtcatgg ccctgctgca caagaacatg aagcacctgt ggttctttct gctgctggtg      60

gccgctccta gatgggtgtt gtctcaggtg cagctggttg aatctggtgg cggagtggtg     120

cagcctggca gatctctgag actggattgc aaggcctccg gcatcacctt ctccaactct     180

ggcatgcact gggtccgaca ggcccctgga aaaggactgg aatgggtcgc cgtgatttgg     240

tacgacggct ctaagcggta ctacgccgac tccgtgaagg gcagattcac catctctcgg     300

gacaactcca agaacaccct gtttctgcag atgaactccc tgagagccga ggacaccgcc     360

gtgtactact gtgccaccaa cgatgattat tggggccagg gcacactggt caccgtgtcc     420

tctgcttcta ccaagggacc ctctgtgttc cctctggctc cttgctccag atccacctct     480

gagtctaccg ctgctctggg ctgcctggtc aaggattact ttcctgagcc tgtgaccgtg     540

tcttggaact ctggtgctct gacctccggc gtgcacacat ttccagctgt gctgcagtcc     600

tccggcctgt actctctgtc ctctgtcgtg accgtgcctt ctagctctct gggcaccaag     660

acctacacct gtaacgtgga ccacaagcct tccaacacca aggtggacaa gcgcgtggaa     720

tctaagtacg gccctccttg tcctccatgt cctgctccag aattcctcgg cggaccttcc     780

gtgttcctgt ttcctccaaa gcctaaggac accctgatga tctctcggac ccctgaagtg     840

acctgcgtgg tggtggatgt gtctcaagag gaccccgagg tgcagttcaa ttggtacgtg     900

gacggcgtgg aagtgcacaa cgccaagacc aagcctagag aggaacagtt caactccacc     960

tacagagtgg tgtccgtgct gaccgtgctg caccaggatt ggctgaacgg caaagagtac    1020

aagtgcaagg tgtccaacaa gggcctgcct tccagcatcg aaaagaccat ctccaaggct    1080

aagggccagc ctcgggaacc tcaggtttac accctgcctc caagccaaga ggaaatgacc    1140

aagaaccagg tgtccctgac ctgcctcgtg aagggattct acccttccga tatcgccgtg    1200

gaatgggagt ccaatggcca gcctgagaac aactacaaga caacccctcc tgtgctggac    1260

tccgacggct ccttctttct gtattcccgc ctgaccgtgg acaagtctag atggcaagag    1320

ggcaacgtgt tctcctgctc tgtgatgcac gaggccctgc acaaccacta cacccagaag    1380

tccctgtctc tgtccctggg caaatgatag                                     1410


<210> 9
<211> 732
<212> DNA
<213> Artificial Sequence


<220> 
<223> Kozak - SP - protein light chain - DNA

<400> 9
tcggtcatgg ccctgctgca caagaacatg aagcacctgt ggttctttct gctgctggtg      60

gccgctccta gatgggtgct gtctgagatc gtgctgaccc agtctcctgc cacattgtct     120

ctgagtcctg gcgagagagc taccctgtct tgcagagctt cccagtccgt gtcctcctac     180

ctggcctggt atcagcagaa acctggacag gcccctcggc tgctgatcta cgatgcctct     240

aatagagcca caggcatccc cgccagattc tctggctctg gatctggcac cgacttcacc     300

ctgaccatct ctagcctgga acctgaggac ttcgccgtgt actactgcca gcagtcctcc     360

aactggccta gaacctttgg ccagggcacc aaggtggaaa tcaagagaac cgtggctgcc     420

ccttccgtgt tcatcttccc accatctgac gagcagctga agtccggcac agcttctgtc     480

gtgtgcctgc tgaacaactt ctaccctcgg gaagccaagg tgcagtggaa ggtggacaat     540

gccctgcagt ccggcaactc ccaagagtct gtgaccgagc aggactccaa ggactctacc     600

tacagcctgt cctccacact gaccctgtct aaggccgact acgagaagca caaggtgtac     660

gcctgtgaag tgacccacca gggactgtct agccccgtga ccaagtcttt caacagaggc     720

gagtgctgat ag                                                         732


<210> 10
<211> 466
<212> PRT
<213> Artificial Sequence


<220> 
<223> SP - protein heavy chain - protein

<400> 10
Met Ala Leu Leu His Lys Asn Met Lys His Leu Trp Phe Phe Leu Leu 
1               5                   10                  15      
Leu Val Ala Ala Pro Arg Trp Val Leu Ser Gln Val Gln Leu Val Glu 
            20                  25                  30          
Ser Gly Gly Gly Val Val Gln Pro Gly Arg Ser Leu Arg Leu Asp Cys 
        35                  40                  45              
Lys Ala Ser Gly Ile Thr Phe Ser Asn Ser Gly Met His Trp Val Arg 
    50                  55                  60                  
Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Val Ile Trp Tyr Asp 
65                  70                  75                  80  
Gly Ser Lys Arg Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile 
                85                  90                  95      
Ser Arg Asp Asn Ser Lys Asn Thr Leu Phe Leu Gln Met Asn Ser Leu 
            100                 105                 110         
Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Thr Asn Asp Asp Tyr 
        115                 120                 125             
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
    130                 135                 140                 
Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser 
145                 150                 155                 160 
Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
                165                 170                 175     
Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
            180                 185                 190         
Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
        195                 200                 205             
Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val 
    210                 215                 220                 
Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys 
225                 230                 235                 240 
Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly 
                245                 250                 255     
Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
            260                 265                 270         
Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu 
        275                 280                 285             
Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
    290                 295                 300                 
Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg 
305                 310                 315                 320 
Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
                325                 330                 335     
Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu 
            340                 345                 350         
Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
        355                 360                 365             
Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
    370                 375                 380                 
Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
385                 390                 395                 400 
Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
                405                 410                 415     
Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp 
            420                 425                 430         
Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His 
        435                 440                 445             
Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu 
    450                 455                 460                 
Gly Lys 
465     

<210> 11
<211> 240
<212> PRT
<213> Artificial Sequence


<220> 
<223> SP - protein light chain - protein

<400> 11
Met Ala Leu Leu His Lys Asn Met Lys His Leu Trp Phe Phe Leu Leu 
1               5                   10                  15      
Leu Val Ala Ala Pro Arg Trp Val Leu Ser Glu Ile Val Leu Thr Gln 
            20                  25                  30          
Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser 
        35                  40                  45              
Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala Trp Tyr Gln Gln 
    50                  55                  60                  
Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Asp Ala Ser Asn Arg 
65                  70                  75                  80  
Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
                85                  90                  95      
Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr 
            100                 105                 110         
Tyr Cys Gln Gln Ser Ser Asn Trp Pro Arg Thr Phe Gly Gln Gly Thr 
        115                 120                 125             
Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe 
    130                 135                 140                 
Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys 
145                 150                 155                 160 
Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val 
                165                 170                 175     
Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln 
            180                 185                 190         
Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser 
        195                 200                 205             
Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His 
    210                 215                 220                 
Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235                 240 



<210> 12
<211> 1422
<212> DNA
<213> Artificial Sequence


<220> 
<223> Restriction site - SP - protein heavy chain - DNA

<400> 12
ggtacctcgg tcatggccct gctgcacaag aacatgaagc acctgtggtt ctttctgctg      60

ctggtggccg ctcctagatg ggtgttgtct caggtgcagc tggttgaatc tggtggcgga     120

gtggtgcagc ctggcagatc tctgagactg gattgcaagg cctccggcat caccttctcc     180

aactctggca tgcactgggt ccgacaggcc cctggaaaag gactggaatg ggtcgccgtg     240

atttggtacg acggctctaa gcggtactac gccgactccg tgaagggcag attcaccatc     300

tctcgggaca actccaagaa caccctgttt ctgcagatga actccctgag agccgaggac     360

accgccgtgt actactgtgc caccaacgat gattattggg gccagggcac actggtcacc     420

gtgtcctctg cttctaccaa gggaccctct gtgttccctc tggctccttg ctccagatcc     480

acctctgagt ctaccgctgc tctgggctgc ctggtcaagg attactttcc tgagcctgtg     540

accgtgtctt ggaactctgg tgctctgacc tccggcgtgc acacatttcc agctgtgctg     600

cagtcctccg gcctgtactc tctgtcctct gtcgtgaccg tgccttctag ctctctgggc     660

accaagacct acacctgtaa cgtggaccac aagccttcca acaccaaggt ggacaagcgc     720

gtggaatcta agtacggccc tccttgtcct ccatgtcctg ctccagaatt cctcggcgga     780

ccttccgtgt tcctgtttcc tccaaagcct aaggacaccc tgatgatctc tcggacccct     840

gaagtgacct gcgtggtggt ggatgtgtct caagaggacc ccgaggtgca gttcaattgg     900

tacgtggacg gcgtggaagt gcacaacgcc aagaccaagc ctagagagga acagttcaac     960

tccacctaca gagtggtgtc cgtgctgacc gtgctgcacc aggattggct gaacggcaaa    1020

gagtacaagt gcaaggtgtc caacaagggc ctgccttcca gcatcgaaaa gaccatctcc    1080

aaggctaagg gccagcctcg ggaacctcag gtttacaccc tgcctccaag ccaagaggaa    1140

atgaccaaga accaggtgtc cctgacctgc ctcgtgaagg gattctaccc ttccgatatc    1200

gccgtggaat gggagtccaa tggccagcct gagaacaact acaagacaac ccctcctgtg    1260

ctggactccg acggctcctt ctttctgtat tcccgcctga ccgtggacaa gtctagatgg    1320

caagagggca acgtgttctc ctgctctgtg atgcacgagg ccctgcacaa ccactacacc    1380

cagaagtccc tgtctctgtc cctgggcaaa tgatagaagc tt                       1422


<210> 13
<211> 744
<212> DNA
<213> Artificial Sequence


<220> 
<223> Restriction site - SP - light chain - DNA

<400> 13
ggatcctcgg tcatggccct gctgcacaag aacatgaagc acctgtggtt ctttctgctg      60

ctggtggccg ctcctagatg ggtgctgtct gagatcgtgc tgacccagtc tcctgccaca     120

ttgtctctga gtcctggcga gagagctacc ctgtcttgca gagcttccca gtccgtgtcc     180

tcctacctgg cctggtatca gcagaaacct ggacaggccc ctcggctgct gatctacgat     240

gcctctaata gagccacagg catccccgcc agattctctg gctctggatc tggcaccgac     300

ttcaccctga ccatctctag cctggaacct gaggacttcg ccgtgtacta ctgccagcag     360

tcctccaact ggcctagaac ctttggccag ggcaccaagg tggaaatcaa gagaaccgtg     420

gctgcccctt ccgtgttcat cttcccacca tctgacgagc agctgaagtc cggcacagct     480

tctgtcgtgt gcctgctgaa caacttctac cctcgggaag ccaaggtgca gtggaaggtg     540

gacaatgccc tgcagtccgg caactcccaa gagtctgtga ccgagcagga ctccaaggac     600

tctacctaca gcctgtcctc cacactgacc ctgtctaagg ccgactacga gaagcacaag     660

gtgtacgcct gtgaagtgac ccaccaggga ctgtctagcc ccgtgaccaa gtctttcaac     720

agaggcgagt gctgatagct cgag                                            744


<210> 14
<211> 11
<212> RNA
<213> Artificial Sequence


<220> 
<223> TIS RNA

<400> 14
ucggucaugg c                                                         11


