                         SEQUENCE LISTING

<110>  NantBio Inc
 
<120>  T Cells That Respond To Patient Neoepitopes

<130>  102719.0027PCT

<150>  62/992,794
<151>  2020-03-20

<150>  63/003,496
<151>  2020-04-01

<160>  32    

<170>  PatentIn version 3.5

<210>  1
<211>  624
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pp65 full length protein

<400>  1

Met Ala Ser Val Leu Gly Pro Ile Ser Gly His Val Leu Lys Ala Val 
1               5                   10                  15      


Phe Ser Arg Gly Asp Thr Pro Val Leu Pro His Glu Thr Arg Leu Leu 
            20                  25                  30          


Gln Thr Gly Ile His Val Arg Val Ser Gln Pro Ser Leu Ile Leu Val 
        35                  40                  45              


Ser Gln Tyr Thr Pro Asp Ser Thr Pro Cys His Arg Gly Asp Asn Gln 
    50                  55                  60                  


Leu Gln Val Gln His Thr Tyr Phe Thr Gly Ser Glu Val Glu Asn Val 
65                  70                  75                  80  


Ser Val Asn Val His Asn Pro Thr Gly Arg Ser Ile Cys Pro Ser Gln 
                85                  90                  95      


Glu Pro Met Ser Ile Tyr Val Tyr Ala Leu Pro Leu Lys Met Leu Asn 
            100                 105                 110         


Ile Pro Ser Ile Asn Val His His Tyr Pro Ser Ala Ala Glu Arg Lys 
        115                 120                 125             


His Arg His Leu Pro Val Ala Asp Ala Val Ile His Ala Ser Gly Lys 
    130                 135                 140                 


Gln Met Trp Gln Ala Arg Leu Thr Val Ser Gly Leu Ala Trp Thr Arg 
145                 150                 155                 160 


Gln Gln Asn Gln Trp Lys Glu Pro Asp Val Tyr Tyr Thr Ser Ala Phe 
                165                 170                 175     


Val Phe Pro Thr Lys Asp Val Ala Leu Arg His Val Val Cys Ala His 
            180                 185                 190         


Glu Leu Val Cys Ser Met Glu Asn Thr Arg Ala Thr Lys Met Gln Val 
        195                 200                 205             


Ile Gly Asp Gln Tyr Val Lys Val Tyr Leu Glu Ser Phe Cys Glu Asp 
    210                 215                 220                 


Val Pro Ser Gly Lys Leu Phe Met His Val Thr Leu Gly Ser Asp Val 
225                 230                 235                 240 


Glu Glu Asp Leu Thr Met Thr Arg Asn Pro Gln Pro Phe Met Arg Pro 
                245                 250                 255     


His Glu Arg Asn Gly Phe Thr Val Leu Cys Pro Lys Asn Met Ile Ile 
            260                 265                 270         


Lys Pro Gly Lys Ile Ser His Ile Met Leu Asp Val Ala Phe Thr Ser 
        275                 280                 285             


His Glu His Phe Gly Leu Leu Cys Pro Lys Ser Ile Pro Gly Leu Ser 
    290                 295                 300                 


Ile Ser Gly Asn Leu Leu Met Asn Gly Gln Gln Ile Phe Leu Glu Val 
305                 310                 315                 320 


Gln Ala Ile Arg Glu Thr Val Glu Leu Arg Gln Tyr Asp Pro Val Ala 
                325                 330                 335     


Ala Leu Phe Phe Phe Asp Ile Asp Leu Leu Leu Gln Arg Gly Pro Gln 
            340                 345                 350         


Tyr Ser Glu His Pro Thr Phe Thr Ser Gln Tyr Arg Ile Gln Gly Lys 
        355                 360                 365             


Leu Glu Tyr Arg His Thr Trp Asp Arg His Asp Glu Gly Ala Ala Gln 
    370                 375                 380                 


Gly Asp Asp Asp Val Trp Thr Ser Gly Ser Asp Ser Asp Glu Glu Leu 
385                 390                 395                 400 


Val Thr Thr Glu Arg Lys Thr Pro Arg Val Thr Gly Gly Gly Ala Met 
                405                 410                 415     


Ala Gly Ala Ser Thr Ser Ala Gly Arg Lys Arg Lys Ser Ala Ser Ser 
            420                 425                 430         


Ala Thr Ala Cys Thr Ala Gly Val Met Thr Arg Gly Arg Leu Lys Ala 
        435                 440                 445             


Glu Ser Thr Val Ala Pro Glu Glu Asp Thr Asp Glu Asp Ser Asp Asn 
    450                 455                 460                 


Glu Ile His Asn Pro Ala Val Phe Thr Trp Pro Pro Trp Gln Ala Gly 
465                 470                 475                 480 


Ile Leu Ala Arg Asn Leu Val Pro Met Val Ala Thr Val Gln Gly Gln 
                485                 490                 495     


Asn Leu Lys Tyr Gln Glu Phe Phe Trp Asp Ala Asn Asp Ile Tyr Arg 
            500                 505                 510         


Ile Phe Ala Glu Leu Glu Gly Val Trp Gln Pro Ala Ala Gln Pro Lys 
        515                 520                 525             


Arg Arg Arg His Arg Gln Asp Ala Leu Pro Gly Pro Cys Ile Ala Ser 
    530                 535                 540                 


Thr Pro Lys Lys His Arg Gly Ala Ala Ala Ala Glu Val Ser Gly Leu 
545                 550                 555                 560 


Glu Gln Leu Glu Ser Ile Ile Asn Phe Glu Lys Leu Thr Glu Trp Thr 
                565                 570                 575     


Ser Ser Asn Val Ala Ala Ala Ala Met Thr Glu Gln Gln Trp Asn Phe 
            580                 585                 590         


Ala Gly Ile Glu Ala Ala Ala Ser Ala Ile Gln Gly Asn Val Thr Ser 
        595                 600                 605             


Ile His Ser Leu Leu Asp Ala Ala Ala Ala His His His His His His 
    610                 615                 620                 


<210>  2
<211>  397
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pp65 Polytope (31mers with flexible linker)

<400>  2

Met Leu Pro His Glu Thr Arg Leu Leu Gln Thr Gly Ile His Val Arg 
1               5                   10                  15      


Val Ser Gln Pro Ser Leu Ile Leu Val Ser Gln Tyr Thr Pro Asp Ser 
            20                  25                  30          


Gly Pro Gly Pro Gly Cys Pro Ser Gln Glu Pro Met Ser Ile Tyr Val 
        35                  40                  45              


Tyr Ala Leu Pro Leu Lys Met Leu Asn Ile Pro Ser Ile Asn Val His 
    50                  55                  60                  


His Tyr Pro Ser Gly Pro Gly Pro Gly Val Ala Asp Ala Val Ile His 
65                  70                  75                  80  


Ala Ser Gly Lys Gln Met Trp Gln Ala Arg Leu Thr Val Ser Gly Leu 
                85                  90                  95      


Ala Trp Thr Arg Gln Gln Asn Gln Gly Pro Gly Pro Gly Gln Gln Asn 
            100                 105                 110         


Gln Trp Lys Glu Pro Asp Val Tyr Tyr Thr Ser Ala Phe Val Phe Pro 
        115                 120                 125             


Thr Lys Asp Val Ala Leu Arg His Val Val Cys Ala Gly Pro Gly Pro 
    130                 135                 140                 


Gly Gln Val Ile Gly Asp Gln Tyr Val Lys Val Tyr Leu Glu Ser Phe 
145                 150                 155                 160 


Cys Glu Asp Val Pro Ser Gly Lys Leu Phe Met His Val Thr Leu Gly 
                165                 170                 175     


Pro Gly Pro Gly Thr Arg Asn Pro Gln Pro Phe Met Arg Pro His Glu 
            180                 185                 190         


Arg Asn Gly Phe Thr Val Leu Cys Pro Lys Asn Met Ile Ile Lys Pro 
        195                 200                 205             


Gly Lys Ser Gly Pro Gly Pro Gly Ile Ser His Ile Met Leu Asp Val 
    210                 215                 220                 


Ala Phe Thr Ser His Glu His Phe Gly Leu Leu Cys Pro Lys Ser Ile 
225                 230                 235                 240 


Pro Gly Leu Ser Ile Ser Gly Gly Pro Gly Pro Gly Thr Val Glu Leu 
                245                 250                 255     


Arg Gln Tyr Asp Pro Val Ala Ala Leu Phe Phe Phe Asp Ile Asp Leu 
            260                 265                 270         


Leu Leu Gln Arg Gly Pro Gln Tyr Ser Glu His Gly Pro Gly Pro Gly 
        275                 280                 285             


Trp Pro Pro Trp Gln Ala Gly Ile Leu Ala Arg Asn Leu Val Pro Met 
    290                 295                 300                 


Val Ala Thr Val Gln Gly Gln Asn Leu Lys Tyr Gln Glu Phe Phe Gly 
305                 310                 315                 320 


Pro Gly Pro Gly Gln Glu Phe Phe Trp Asp Ala Asn Asp Ile Tyr Arg 
                325                 330                 335     


Ile Phe Ala Glu Leu Glu Gly Val Trp Gln Pro Ala Ala Gln Pro Lys 
            340                 345                 350         


Arg Arg Arg Gly Pro Gly Pro Gly Ser Ile Pro Gly Leu Ser Ile Ser 
        355                 360                 365             


Gly Asn Leu Leu Met Asn Gly Gln Gln Ile Phe Leu Glu Val Gln Ala 
    370                 375                 380                 


Ile Arg Glu Thr Val Glu Leu His His His His His His 
385                 390                 395         


<210>  3
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PP65 peptide

<400>  3

Asn Leu Val Pro Met Val Ala Thr Val 
1               5                   


<210>  4
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PP65 peptide2

<400>  4

Tyr Thr Ser Ala Phe Val Phe Pro Thr 
1               5                   


<210>  5
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PP65 peptide3

<400>  5

Arg Ile Phe Ala Glu Leu Glu Gly Val 
1               5                   


<210>  6
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PP65 peptide4

<400>  6

Leu Met Asn Gly Gln Gln Ile Phe Leu 
1               5                   


<210>  7
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PP65 peptide5

<400>  7

Met Leu Asn Ile Pro Ser Ile Asn Val 
1               5                   


<210>  8
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PP65 peptide6

<400>  8

Gln Met Trp Gln Ala Arg Leu Thr Val 
1               5                   


<210>  9
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PP65 peptide7

<400>  9

Arg Leu Leu Gln Thr Gly Ile His Val 
1               5                   


<210>  10
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PP65 peptide8

<400>  10

Ser Ile Tyr Val Tyr Ala Leu Pro Leu 
1               5                   


<210>  11
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PP65 peptide9

<400>  11

Ala Leu Phe Phe Phe Asp Ile Asp Leu 
1               5                   


<210>  12
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PP65 peptide10

<400>  12

Ile Met Leu Asp Val Ala Phe Thr Ser 
1               5                   


<210>  13
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PP65 peptide11

<400>  13

Tyr Leu Glu Ser Phe Cys Glu Asp Val 
1               5                   


<210>  14
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PP65 peptide12

<400>  14

Thr Gly Ile His Val Arg Val Ser Gln Pro Ser Leu Ile Leu Val Ser 
1               5                   10                  15      


Gln 
    


<210>  15
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PP65 peptide13

<400>  15

Ser His Glu His Phe Gly Leu Leu Cys Pro Lys Ser Ile Pro Gly Leu 
1               5                   10                  15      


<210>  16
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PP65 peptide14

<400>  16

Glu Arg Asn Gly Phe Thr Val Leu Cys Pro Lys Asn Met Ile Ile Lys 
1               5                   10                  15      


<210>  17
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PP65 peptide15

<400>  17

Tyr Ala Leu Pro Leu Lys Met Leu Asn Ile Pro Ser Ile Asn Val His 
1               5                   10                  15      


His 
    


<210>  18
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  transcription seq1

<400>  18
cttctaatac gactcactat ag                                                22


<210>  19
<211>  104
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  transcription seq2

<400>  19
gaagattatg ctgagtgata tcccgaattc atattcctcc ttatttatac gaacgtgcat       60

tagaacatgg ataccaacgt tgacaagttc cagttatcat tact                       104


<210>  20
<211>  83
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  transcription seq3

<400>  20
gggcuuaagu auaaggagga auaaauaugc uugcacguaa ucuuguaccu augguugcaa       60

cuguucaagg ucaauaguaa uga                                               83


<210>  21
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  transcription seq4

<400>  21

Met Leu Ala Arg Asn Leu Val Pro Met Val Ala Thr Val Gln Gly Gln 
1               5                   10                  15      


<210>  22
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IVT&T peptide1

<400>  22

Glu Thr Arg Leu Leu Gln Thr Gly Ile His Val Arg Val Ser Gln Pro 
1               5                   10                  15      


Ser Leu Ile Leu Val Ser Gln Tyr Thr 
            20                  25  


<210>  23
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IVT&T peptide2

<400>  23

Gln Glu Pro Met Ser Ile Tyr Val Tyr Ala Leu Pro Leu Lys Met Leu 
1               5                   10                  15      


Asn Ile Pro Ser Ile Asn Val His His 
            20                  25  


<210>  24
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IVT&T peptide3

<400>  24

Ala Val Ile His Ala Ser Gly Lys Gln Met Trp Gln Ala Arg Leu Thr 
1               5                   10                  15      


Val Ser Gly Leu Ala Trp Thr Arg Gln 
            20                  25  


<210>  25
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IVT&T peptide4

<400>  25

Gln Trp Lys Glu Pro Asp Val Tyr Tyr Thr Ser Ala Phe Val Phe Pro 
1               5                   10                  15      


Thr Lys Asp Val Ala Leu Arg His Val 
            20                  25  


<210>  26
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IVT&T peptide5

<400>  26

Ile Gly Asp Gln Tyr Val Lys Val Tyr Leu Glu Ser Phe Cys Glu Asp 
1               5                   10                  15      


Val Pro Ser Gly Lys Leu Phe Met His 
            20                  25  


<210>  27
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IVT&T peptide6

<400>  27

Phe Met Arg Pro His Glu Arg Asn Gly Phe Thr Val Leu Cys Pro Lys 
1               5                   10                  15      


Asn Met Ile Ile Lys Pro Gly Lys Ile 
            20                  25  


<210>  28
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IVT&T peptide7

<400>  28

Ile Met Leu Asp Val Ala Phe Thr Ser His Glu His Phe Gly Leu Leu 
1               5                   10                  15      


Cys Pro Lys Ser Ile Pro Gly Leu Ser 
            20                  25  


<210>  29
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IVT&T peptide8

<400>  29

Leu Arg Gln Tyr Asp Pro Val Ala Ala Leu Phe Phe Phe Asp Ile Asp 
1               5                   10                  15      


Leu Leu Leu Gln Arg Gly Pro Gln Tyr 
            20                  25  


<210>  30
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IVT&T peptide9

<400>  30

Trp Gln Ala Gly Ile Leu Ala Arg Asn Leu Val Pro Met Val Ala Thr 
1               5                   10                  15      


Val Gln Gly Gln Asn Leu Lys Tyr Gln 
            20                  25  


<210>  31
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IVT&T peptide10

<400>  31

Phe Trp Asp Ala Asn Asp Ile Tyr Arg Ile Phe Ala Glu Leu Glu Gly 
1               5                   10                  15      


Val Trp Gln Pro Ala Ala Gln Pro Lys 
            20                  25  


<210>  32
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IVT&T peptide11

<400>  32

Gly Leu Ser Ile Ser Gly Asn Leu Leu Met Asn Gly Gln Gln Ile Phe 
1               5                   10                  15      


Leu Glu Val Gln Ala Ile Arg Glu Thr 
            20                  25  


