                         SEQUENCE LISTING

<110>  SkinGen International
 
<120>  COMPOSITIONS HAVING MULTIPLE RECOMBINANT HUMAN GROWTH FACTORS 
       INCLUDED THEREIN FOR REDUCING SIGNS OF AGING

<130>  305406-238544

<150>  62/991854
<151>  2020-03-19

<160>  13    

<170>  PatentIn version 3.5

<210>  1
<211>  463
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Hepatocyte Growth Factor (HGF) f

<400>  1

Gln Arg Lys Arg Arg Asn Thr Ile His Glu Phe Lys Lys Ser Ala Lys 
1               5                   10                  15      


Thr Thr Leu Ile Lys Ile Asp Pro Ala Leu Lys Ile Lys Thr Lys Lys 
            20                  25                  30          


Val Asn Thr Ala Asp Gln Cys Ala Asn Arg Cys Thr Arg Asn Lys Gly 
        35                  40                  45              


Leu Pro Phe Thr Cys Lys Ala Phe Val Phe Asp Lys Ala Arg Lys Gln 
    50                  55                  60                  


Cys Leu Trp Phe Pro Phe Asn Ser Met Ser Ser Gly Val Lys Lys Glu 
65                  70                  75                  80  


Phe Gly His Glu Phe Asp Leu Tyr Glu Asn Lys Asp Tyr Ile Arg Asn 
                85                  90                  95      


Cys Ile Ile Gly Lys Gly Arg Ser Tyr Lys Gly Thr Val Ser Ile Thr 
            100                 105                 110         


Lys Ser Gly Ile Lys Cys Gln Pro Trp Ser Ser Met Ile Pro His Glu 
        115                 120                 125             


His Ser Phe Leu Pro Ser Ser Tyr Arg Gly Lys Asp Leu Gln Glu Asn 
    130                 135                 140                 


Tyr Cys Arg Asn Pro Arg Gly Glu Glu Gly Gly Pro Trp Cys Phe Thr 
145                 150                 155                 160 


Ser Asn Pro Glu Val Arg Tyr Glu Val Cys Asp Ile Pro Gln Cys Ser 
                165                 170                 175     


Glu Val Glu Cys Met Thr Cys Asn Gly Glu Ser Tyr Arg Gly Leu Met 
            180                 185                 190         


Asp His Thr Glu Ser Gly Lys Ile Cys Gln Arg Trp Asp His Gln Thr 
        195                 200                 205             


Pro His Arg His Lys Phe Leu Pro Glu Arg Tyr Pro Asp Lys Gly Phe 
    210                 215                 220                 


Asp Asp Asn Tyr Cys Arg Asn Pro Asp Gly Gln Pro Arg Pro Trp Cys 
225                 230                 235                 240 


Tyr Thr Leu Asp Pro His Thr Arg Trp Glu Tyr Cys Ala Ile Lys Thr 
                245                 250                 255     


Cys Ala Asp Asn Thr Met Asn Asp Thr Asp Val Pro Leu Glu Thr Thr 
            260                 265                 270         


Glu Cys Ile Gln Gly Gln Gly Glu Gly Tyr Arg Gly Thr Val Asn Thr 
        275                 280                 285             


Ile Trp Asn Gly Ile Pro Cys Gln Arg Trp Asp Ser Gln Tyr Pro His 
    290                 295                 300                 


Glu His Asp Met Thr Pro Glu Asn Phe Lys Cys Lys Asp Leu Arg Glu 
305                 310                 315                 320 


Asn Tyr Cys Arg Asn Pro Asp Gly Ser Glu Ser Pro Trp Cys Phe Thr 
                325                 330                 335     


Thr Asp Pro Asn Ile Arg Val Gly Tyr Cys Ser Gln Ile Pro Asn Cys 
            340                 345                 350         


Asp Met Ser His Gly Gln Asp Cys Tyr Arg Gly Asn Gly Lys Asn Tyr 
        355                 360                 365             


Met Gly Asn Leu Ser Gln Thr Arg Ser Gly Leu Thr Cys Ser Met Trp 
    370                 375                 380                 


Asp Lys Asn Met Glu Asp Leu His Arg His Ile Phe Trp Glu Pro Asp 
385                 390                 395                 400 


Ala Ser Lys Leu Asn Glu Asn Tyr Cys Arg Asn Pro Asp Asp Asp Ala 
                405                 410                 415     


His Gly Pro Trp Cys Tyr Thr Gly Asn Pro Leu Ile Pro Trp Asp Tyr 
            420                 425                 430         


Cys Pro Ile Ser Arg Cys Glu Gly Asp Thr Thr Pro Thr Ile Val Asn 
        435                 440                 445             


Leu Asp His Pro Val Ile Ser Cys Ala Lys Thr Lys Gln Leu Arg 
    450                 455                 460             


<210>  2
<211>  148
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Fibroblast Growth Factor mutant

<400>  2

Pro Ala Leu Pro Glu Asp Gly Gly Ser Gly Ala Phe Pro Pro Gly His 
1               5                   10                  15      


Phe Lys Asp Pro Lys Arg Leu Tyr Cys Lys Asn Gly Gly Phe Phe Leu 
            20                  25                  30          


Arg Ile His Pro Asp Gly Arg Val Asp Gly Val Arg Glu Lys Ser Asp 
        35                  40                  45              


Pro His Ile Lys Leu Gln Leu Gly Ile Asn Ala Glu Glu Arg Gly Val 
    50                  55                  60                  


Val Ser Ile Lys Gly Val Cys Ala Asn Arg Tyr Leu Ala Met Lys Glu 
65                  70                  75                  80  


Asp Gly Arg Leu Leu Ala Ser Lys Cys Val Thr Asp Glu Cys Phe Phe 
                85                  90                  95      


Phe Glu Arg Leu Glu Ser Asn Asn Tyr Asn Thr Tyr Arg Ser Arg Lys 
            100                 105                 110         


Tyr Thr Ser Trp Tyr Val Ala Leu Lys Arg Thr Gly Gln Tyr Lys Leu 
        115                 120                 125             


Gly Ser Lys Thr Gly Pro Gly Gln Lys Ala Ile Leu Phe Leu Pro Met 
    130                 135                 140                 


Ser Ala Lys Ser 
145             


<210>  3
<211>  140
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic aFGF or FGF-1 (acidic Fibroblast Growth Factor)

<400>  3

Phe Asn Leu Pro Pro Gly Asn Tyr Lys Lys Pro Lys Leu Leu Tyr Cys 
1               5                   10                  15      


Ser Asn Gly Gly His Phe Leu Arg Ile Leu Pro Asp Gly Thr Val Asp 
            20                  25                  30          


Gly Thr Arg Asp Arg Ser Asp Gln His Ile Gln Leu Gln Leu Ser Ala 
        35                  40                  45              


Glu Ser Val Gly Glu Val Tyr Ile Lys Ser Thr Glu Thr Gly Gln Tyr 
    50                  55                  60                  


Leu Ala Met Asp Thr Asp Gly Leu Leu Tyr Gly Ser Gln Thr Pro Asn 
65                  70                  75                  80  


Glu Glu Cys Leu Phe Leu Glu Arg Leu Glu Glu Asn His Tyr Asn Thr 
                85                  90                  95      


Tyr Ile Ser Lys Lys His Ala Glu Lys Asn Trp Phe Val Gly Leu Lys 
            100                 105                 110         


Lys Asn Gly Ser Cys Lys Arg Gly Pro Arg Thr His Tyr Gly Gln Lys 
        115                 120                 125             


Ala Ile Leu Phe Leu Pro Leu Pro Val Ser Ser Asp 
    130                 135                 140 


<210>  4
<211>  67
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic IGF-2 (Insulin-like Growth Factor 2)

<400>  4

Ala Tyr Arg Pro Ser Glu Thr Leu Cys Gly Gly Glu Leu Val Asp Thr 
1               5                   10                  15      


Leu Gln Phe Val Cys Gly Asp Arg Gly Phe Tyr Phe Ser Arg Pro Ala 
            20                  25                  30          


Ser Arg Val Ser Arg Arg Ser Arg Gly Ile Val Glu Glu Cys Cys Phe 
        35                  40                  45              


Arg Ser Cys Asp Leu Ala Leu Leu Glu Thr Tyr Cys Ala Thr Pro Ala 
    50                  55                  60                  


Lys Ser Glu 
65          


<210>  5
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic epidermal growth factor (EGF) polypeptide mutant

<400>  5

Met Leu Lys Glu Trp Glu Leu Arg 
1               5               


<210>  6
<211>  70
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic IGF-1 (Insulin-like Growth Factor 1)

<400>  6

Gly Pro Glu Thr Leu Cys Gly Ala Glu Leu Val Asp Ala Leu Gln Phe 
1               5                   10                  15      


Val Cys Gly Asp Arg Gly Phe Tyr Phe Asn Lys Pro Thr Gly Tyr Gly 
            20                  25                  30          


Ser Ser Ser Arg Arg Ala Pro Gln Thr Gly Ile Val Asp Glu Cys Cys 
        35                  40                  45              


Phe Arg Ser Cys Asp Leu Arg Arg Leu Glu Met Tyr Cys Ala Pro Leu 
    50                  55                  60                  


Lys Pro Ala Lys Ser Ala 
65                  70  


<210>  7
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic KGF-2 or FGF-10 (Keratinocyte Growth Factor 2)

<400>  7

Gln Ala Leu Gly Gln Asp Met Val Ser Pro Glu Ala Thr Asn Ser Ser 
1               5                   10                  15      


Ser Ser Ser Phe Ser Ser Pro Ser Ser Ala Gly Arg His Val Arg Ser 
            20                  25                  30          


Tyr Asn His Leu Gln Gly Asp Val Arg Trp Arg Lys Leu Phe Ser Phe 
        35                  40                  45              


Thr Lys Tyr Phe Leu Lys Ile Glu Lys Asn Gly Lys Val Ser Gly Thr 
    50                  55                  60                  


Lys Lys Glu Asn Cys Pro Tyr Ser Ile Leu Glu Ile Thr Ser Val Glu 
65                  70                  75                  80  


Ile Gly Val Val Ala Val Lys Ala Ile Asn Ser Asn Tyr Tyr Leu Ala 
                85                  90                  95      


Met Asn Lys Lys Gly Lys Leu Tyr Gly Ser Lys Glu Phe Asn Asn Asp 
            100                 105                 110         


Cys Lys Leu Lys Glu Arg Ile Glu 
        115                 120 


<210>  8
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic TGF-I33 (Transforming Growth Factor-I33)

<400>  8

Ala Leu Asp Thr Asn Tyr Cys Phe Arg Asn Leu Glu Glu Asn Cys Cys 
1               5                   10                  15      


Val Arg Pro Leu Tyr Ile Asp Phe Arg Gln Asp Leu Gly Trp Lys Trp 
            20                  25                  30          


Val His Glu Pro Lys Gly Tyr Tyr Ala Asn Phe Cys Ser Gly Pro Cys 
        35                  40                  45              


Pro Tyr Leu Arg Ser Ala Asp Thr Thr His Ser Thr Val Leu Gly Leu 
    50                  55                  60                  


Tyr Asn Thr Leu Asn Pro Glu Ala Ser Ala Ser Pro Cys Cys Val Pro 
65                  70                  75                  80  


Gln Asp Leu Glu Pro Leu Thr Ile Leu Tyr Tyr Val Gly Arg Thr Pro 
                85                  90                  95      


Lys Val Glu Gln Leu Ser Asn Met Val Val Lys Ser Cys Lys Cys Ser 
            100                 105                 110         


<210>  9
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic PDGF (Platelet-Derived Growth Factor)

<400>  9

Ser Ile Glu Glu Ala Val Pro Ala Val Cys Lys Thr Arg Thr Val Ile 
1               5                   10                  15      


Tyr Glu Ile Pro Arg Ser Gln Val Asp Pro Thr Ser Ala Asn Phe Leu 
            20                  25                  30          


Ile Trp Pro Pro Cys Val Glu Val Lys Arg Cys Thr Gly Cys Cys Asn 
        35                  40                  45              


Thr Ser Ser Val Lys Cys Gln Pro Ser Arg Val His His Arg Ser Val 
    50                  55                  60                  


Lys Val Ala Lys Val Glu Tyr Val Arg Lys Lys Pro Lys Leu Lys Glu 
65                  70                  75                  80  


Val Gln Val Arg Leu Glu Glu His Leu Glu Cys Ala Cys Ala Thr Thr 
                85                  90                  95      


Ser Leu Asn Pro Asp Tyr Arg Glu Glu Asp Thr Gly Arg Pro Arg Glu 
            100                 105                 110         


Ser Gly Lys Lys Arg Lys Arg Lys Arg Leu Lys Pro Thr 
        115                 120                 125 


<210>  10
<211>  163
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic KGF or FGF-7 (Keratinocyte Growth Factor)

<400>  10

Cys Asn Asp Met Thr Pro Glu Gln Met Ala Thr Asn Val Asn Cys Ser 
1               5                   10                  15      


Ser Pro Glu Arg His Thr Arg Ser Tyr Asp Tyr Met Glu Gly Gly Asp 
            20                  25                  30          


Ile Arg Val Arg Arg Leu Phe Cys Arg Thr Gln Trp Tyr Leu Arg Ile 
        35                  40                  45              


Asp Lys Arg Gly Lys Val Lys Gly Thr Gln Glu Met Lys Asn Asn Tyr 
    50                  55                  60                  


Asn Ile Met Glu Ile Arg Thr Val Ala Val Gly Ile Val Ala Ile Lys 
65                  70                  75                  80  


Gly Val Glu Ser Glu Phe Tyr Leu Ala Met Asn Lys Glu Gly Lys Leu 
                85                  90                  95      


Tyr Ala Lys Lys Glu Cys Asn Glu Asp Cys Asn Phe Lys Glu Leu Ile 
            100                 105                 110         


Leu Glu Asn His Tyr Asn Thr Tyr Ala Ser Ala Lys Trp Thr His Asn 
        115                 120                 125             


Gly Gly Glu Met Phe Val Ala Leu Asn Gln Lys Gly Ile Pro Val Arg 
    130                 135                 140                 


Gly Lys Lys Thr Lys Lys Glu Gln Lys Thr Ala His Phe Leu Pro Met 
145                 150                 155                 160 


Ala Ile Thr 
            


<210>  11
<211>  53
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic epidermal growth factor (EGF) polypeptide mutant

<400>  11

Asn Ser Asp Ser Glu Cys Pro Ser Ser His Asp Gly Tyr Cys Leu His 
1               5                   10                  15      


Asp Gly Val Cys Met Tyr Ile Glu Ala Leu Asp Lys Tyr Ala Cys Asn 
            20                  25                  30          


Cys Val Val Gly Tyr Cys Gly Glu Arg Cys Gln Tyr Arg Cys Leu Lys 
        35                  40                  45              


Trp Trp Glu Leu Arg 
    50              


<210>  12
<211>  165
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic SCF (Stem Cell Factor)

<400>  12

Glu Gly Ile Cys Arg Asn Arg Val Thr Asn Asn Val Lys Asp Val Thr 
1               5                   10                  15      


Lys Leu Val Ala Asn Leu Pro Lys Asp Tyr Met Ile Thr Leu Lys Tyr 
            20                  25                  30          


Val Pro Gly Met Asp Val Leu Pro Ser His Cys Trp Ile Ser Glu Met 
        35                  40                  45              


Val Val Gln Leu Ser Asp Ser Leu Thr Asp Leu Leu Asp Lys Phe Ser 
    50                  55                  60                  


Asn Ile Ser Glu Gly Leu Ser Asn Tyr Ser Ile Ile Asp Lys Leu Val 
65                  70                  75                  80  


Asn Ile Val Asp Asp Leu Val Glu Cys Val Lys Glu Asn Ser Ser Lys 
                85                  90                  95      


Asp Leu Lys Lys Ser Phe Lys Ser Pro Glu Pro Arg Leu Phe Thr Pro 
            100                 105                 110         


Glu Glu Phe Phe Arg Ile Phe Asn Arg Ser Ile Asp Ala Phe Lys Asp 
        115                 120                 125             


Phe Val Val Ala Ser Glu Thr Ser Asp Cys Val Val Ser Ser Thr Leu 
    130                 135                 140                 


Ser Pro Glu Lys Asp Ser Arg Val Ser Val Thr Lys Pro Phe Met Leu 
145                 150                 155                 160 


Pro Pro Val Ala Ala 
                165 


<210>  13
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Noggin derived peptide

<400>  13

His Tyr Leu His Ile Arg Pro Ala Pro Ser Asp 
1               5                   10      


