                         SEQUENCE LISTING

<110>  Ospedale San Raffaele S.r.l.
 
<120>  NGR CONJUGATES AND USES THEREOF

<130>  PCT 146877

<150>  EP20164689.0
<151>  2020-03-20

<160>  43    

<170>  PatentIn version 3.5

<210>  1
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  1

Cys Asn Gly Arg Cys Gly 
1               5       


<210>  2
<211>  4
<212>  PRT
<213>  Homo sapiens

<400>  2

Ile Glu Gly Arg 
1               


<210>  3
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  3

Ser Cys Asn Gly Arg Cys Gly Val Arg Tyr 
1               5                   10  


<210>  4
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  4

Cys Asn Gly Arg Cys Gly Val Arg Tyr 
1               5                   


<210>  5
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  5

Cys Asn Gly Arg Cys 
1               5   


<210>  6
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  6

Ser Cys Asn Gly Arg Cys Gly 
1               5           


<210>  7
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  7

Lys Asn Gly Arg Glu 
1               5   


<210>  8
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  8

Cys Gly Asn Gly Arg Gly 
1               5       


<210>  9
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  9

Gly Asn Gly Arg Gly 
1               5   


<210>  10
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  10

Asn Gly Arg Ala His Ala 
1               5       


<210>  11
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  11

Cys Asp Gly Arg Cys 
1               5   


<210>  12
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  12

Cys Val Leu Asn Gly Arg Met Glu Cys 
1               5                   


<210>  13
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  13

Asn Gly Arg Ala Gly Gly 
1               5       


<210>  14
<211>  157
<212>  PRT
<213>  Homo sapiens

<400>  14

Val Arg Ser Ser Ser Arg Thr Pro Ser Asp Lys Pro Val Ala His Val 
1               5                   10                  15      


Val Ala Asn Pro Gln Ala Glu Gly Gln Leu Gln Trp Leu Asn Arg Arg 
            20                  25                  30          


Ala Asn Ala Leu Leu Ala Asn Gly Val Glu Leu Arg Asp Asn Gln Leu 
        35                  40                  45              


Val Val Pro Ser Glu Gly Leu Tyr Leu Ile Tyr Ser Gln Val Leu Phe 
    50                  55                  60                  


Lys Gly Gln Gly Cys Pro Ser Thr His Val Leu Leu Thr His Thr Ile 
65                  70                  75                  80  


Ser Arg Ile Ala Val Ser Tyr Gln Thr Lys Val Asn Leu Leu Ser Ala 
                85                  90                  95      


Ile Lys Ser Pro Cys Gln Arg Glu Thr Pro Glu Gly Ala Glu Ala Lys 
            100                 105                 110         


Pro Trp Tyr Glu Pro Ile Tyr Leu Gly Gly Val Phe Gln Leu Glu Lys 
        115                 120                 125             


Gly Asp Arg Leu Ser Ala Glu Ile Asn Arg Pro Asp Tyr Leu Asp Phe 
    130                 135                 140                 


Ala Glu Ser Gly Gln Val Tyr Phe Gly Ile Ile Ala Leu 
145                 150                 155         


<210>  15
<211>  156
<212>  PRT
<213>  Mus musculus

<400>  15

Leu Arg Ser Ser Ser Gln Asn Ser Ser Asp Lys Pro Val Ala His Val 
1               5                   10                  15      


Val Ala Asn His Gln Val Glu Glu Gln Leu Glu Trp Leu Ser Gln Arg 
            20                  25                  30          


Ala Asn Ala Leu Leu Ala Asn Gly Met Asp Leu Lys Asp Asn Gln Leu 
        35                  40                  45              


Val Val Pro Ala Asp Gly Leu Tyr Leu Val Tyr Ser Gln Val Leu Phe 
    50                  55                  60                  


Lys Gly Gln Gly Cys Pro Asp Tyr Val Leu Leu Thr His Thr Val Ser 
65                  70                  75                  80  


Arg Phe Ala Ile Ser Tyr Gln Glu Lys Val Asn Leu Leu Ser Ala Val 
                85                  90                  95      


Lys Ser Pro Cys Pro Lys Asp Thr Pro Glu Gly Ala Glu Leu Lys Pro 
            100                 105                 110         


Trp Tyr Glu Pro Ile Tyr Leu Gly Gly Val Phe Gln Leu Glu Lys Gly 
        115                 120                 125             


Asp Gln Leu Ser Ala Glu Val Asn Leu Pro Lys Tyr Leu Asp Phe Ala 
    130                 135                 140                 


Glu Ser Gly Gln Val Tyr Phe Gly Val Ile Ala Leu 
145                 150                 155     


<210>  16
<211>  20
<212>  PRT
<213>  Escherichia coli

<400>  16

Met Arg Ala Lys Leu Leu Gly Ile Val Leu Thr Thr Pro Ile Ala Ile 
1               5                   10                  15      


Ser Ser Phe Ala 
            20  


<210>  17
<211>  8
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  acetyl-Ciso or Ciso or SCiso

<400>  17

Asp Gly Arg Cys Gly Val Arg Tyr 
1               5               


<210>  18
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  18

Cys Asn Gly Arg Cys Gly Val Arg Ser Ser Ser Arg Thr Pro Ser 
1               5                   10                  15  


<210>  19
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  19

Ala Cys Asp Cys Arg Gly Asp Cys Phe Cys Gly 
1               5                   10      


<210>  20
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  20

Ser Gly Cys Asn Gly Arg Cys 
1               5           


<210>  21
<211>  22
<212>  PRT
<213>  Homo sapiens

<400>  21

Leu Leu Gly Ile Val Leu Thr Thr Pro Ile Ala Ile Ser Ser Phe Ala 
1               5                   10                  15      


Ser Thr Cys Asn Gly Arg 
            20          


<210>  22
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  22

Ser Cys Asp Gly Arg Cys Gly Val Arg Tyr 
1               5                   10  


<210>  23
<211>  19
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  23

Met Arg Phe Pro Ser Ile Phe Thr Ala Val Leu Phe Ala Ala Ser Ser 
1               5                   10                  15      


Ala Leu Ala 
            


<210>  24
<211>  184
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  conjugate

<400>  24

Met Arg Ala Lys Leu Leu Gly Ile Val Leu Thr Thr Pro Ile Ala Ile 
1               5                   10                  15      


Ser Ser Phe Ala Ser Thr Cys Asn Gly Arg Cys Gly Leu Arg Ser Ser 
            20                  25                  30          


Ser Gln Asn Ser Ser Asp Lys Pro Val Ala His Val Val Ala Asn His 
        35                  40                  45              


Gln Val Glu Glu Gln Leu Glu Trp Leu Ser Gln Arg Ala Asn Ala Leu 
    50                  55                  60                  


Leu Ala Asn Gly Met Asp Leu Lys Asp Asn Gln Leu Val Val Pro Ala 
65                  70                  75                  80  


Asp Gly Leu Tyr Leu Val Tyr Ser Gln Val Leu Phe Lys Gly Gln Gly 
                85                  90                  95      


Cys Pro Asp Tyr Val Leu Leu Thr His Thr Val Ser Arg Phe Ala Ile 
            100                 105                 110         


Ser Tyr Gln Glu Lys Val Asn Leu Leu Ser Ala Val Lys Ser Pro Cys 
        115                 120                 125             


Pro Lys Asp Thr Pro Glu Gly Ala Glu Leu Lys Pro Trp Tyr Glu Pro 
    130                 135                 140                 


Ile Tyr Leu Gly Gly Val Phe Gln Leu Glu Lys Gly Asp Gln Leu Ser 
145                 150                 155                 160 


Ala Glu Val Asn Leu Pro Lys Tyr Leu Asp Phe Ala Glu Ser Gly Gln 
                165                 170                 175     


Val Tyr Phe Gly Val Ile Ala Leu 
            180                 


<210>  25
<211>  164
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  conjugate

<400>  25

Met Ser Cys Asn Gly Arg Cys Gly Leu Arg Ser Ser Ser Gln Asn Ser 
1               5                   10                  15      


Ser Asp Lys Pro Val Ala His Val Val Ala Asn His Gln Val Glu Glu 
            20                  25                  30          


Gln Leu Glu Trp Leu Ser Gln Arg Ala Asn Ala Leu Leu Ala Asn Gly 
        35                  40                  45              


Met Asp Leu Lys Asp Asn Gln Leu Val Val Pro Ala Asp Gly Leu Tyr 
    50                  55                  60                  


Leu Val Tyr Ser Gln Val Leu Phe Lys Gly Gln Gly Cys Pro Asp Tyr 
65                  70                  75                  80  


Val Leu Leu Thr His Thr Val Ser Arg Phe Ala Ile Ser Tyr Gln Glu 
                85                  90                  95      


Lys Val Asn Leu Leu Ser Ala Val Lys Ser Pro Cys Pro Lys Asp Thr 
            100                 105                 110         


Pro Glu Gly Ala Glu Leu Lys Pro Trp Tyr Glu Pro Ile Tyr Leu Gly 
        115                 120                 125             


Gly Val Phe Gln Leu Glu Lys Gly Asp Gln Leu Ser Ala Glu Val Asn 
    130                 135                 140                 


Leu Pro Lys Tyr Leu Asp Phe Ala Glu Ser Gly Gln Val Tyr Phe Gly 
145                 150                 155                 160 


Val Ile Ala Leu 
                


<210>  26
<211>  163
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  conjugate

<400>  26

Ser Cys Asn Gly Arg Cys Gly Leu Arg Ser Ser Ser Gln Asn Ser Ser 
1               5                   10                  15      


Asp Lys Pro Val Ala His Val Val Ala Asn His Gln Val Glu Glu Gln 
            20                  25                  30          


Leu Glu Trp Leu Ser Gln Arg Ala Asn Ala Leu Leu Ala Asn Gly Met 
        35                  40                  45              


Asp Leu Lys Asp Asn Gln Leu Val Val Pro Ala Asp Gly Leu Tyr Leu 
    50                  55                  60                  


Val Tyr Ser Gln Val Leu Phe Lys Gly Gln Gly Cys Pro Asp Tyr Val 
65                  70                  75                  80  


Leu Leu Thr His Thr Val Ser Arg Phe Ala Ile Ser Tyr Gln Glu Lys 
                85                  90                  95      


Val Asn Leu Leu Ser Ala Val Lys Ser Pro Cys Pro Lys Asp Thr Pro 
            100                 105                 110         


Glu Gly Ala Glu Leu Lys Pro Trp Tyr Glu Pro Ile Tyr Leu Gly Gly 
        115                 120                 125             


Val Phe Gln Leu Glu Lys Gly Asp Gln Leu Ser Ala Glu Val Asn Leu 
    130                 135                 140                 


Pro Lys Tyr Leu Asp Phe Ala Glu Ser Gly Gln Val Tyr Phe Gly Val 
145                 150                 155                 160 


Ile Ala Leu 
            


<210>  27
<211>  165
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  conjugate

<400>  27

Met Ser Cys Asn Gly Arg Cys Gly Val Arg Ser Ser Ser Arg Thr Pro 
1               5                   10                  15      


Ser Asp Lys Pro Val Ala His Val Val Ala Asn Pro Gln Ala Glu Gly 
            20                  25                  30          


Gln Leu Gln Trp Leu Asn Arg Arg Ala Asn Ala Leu Leu Ala Asn Gly 
        35                  40                  45              


Val Glu Leu Arg Asp Asn Gln Leu Val Val Pro Ser Glu Gly Leu Tyr 
    50                  55                  60                  


Leu Ile Tyr Ser Gln Val Leu Phe Lys Gly Gln Gly Cys Pro Ser Thr 
65                  70                  75                  80  


His Val Leu Leu Thr His Thr Ile Ser Arg Ile Ala Val Ser Tyr Gln 
                85                  90                  95      


Thr Lys Val Asn Leu Leu Ser Ala Ile Lys Ser Pro Cys Gln Arg Glu 
            100                 105                 110         


Thr Pro Glu Gly Ala Glu Ala Lys Pro Trp Tyr Glu Pro Ile Tyr Leu 
        115                 120                 125             


Gly Gly Val Phe Gln Leu Glu Lys Gly Asp Arg Leu Ser Ala Glu Ile 
    130                 135                 140                 


Asn Arg Pro Asp Tyr Leu Asp Phe Ala Glu Ser Gly Gln Val Tyr Phe 
145                 150                 155                 160 


Gly Ile Ile Ala Leu 
                165 


<210>  28
<211>  164
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  conjugate

<400>  28

Ser Cys Asn Gly Arg Cys Gly Val Arg Ser Ser Ser Arg Thr Pro Ser 
1               5                   10                  15      


Asp Lys Pro Val Ala His Val Val Ala Asn Pro Gln Ala Glu Gly Gln 
            20                  25                  30          


Leu Gln Trp Leu Asn Arg Arg Ala Asn Ala Leu Leu Ala Asn Gly Val 
        35                  40                  45              


Glu Leu Arg Asp Asn Gln Leu Val Val Pro Ser Glu Gly Leu Tyr Leu 
    50                  55                  60                  


Ile Tyr Ser Gln Val Leu Phe Lys Gly Gln Gly Cys Pro Ser Thr His 
65                  70                  75                  80  


Val Leu Leu Thr His Thr Ile Ser Arg Ile Ala Val Ser Tyr Gln Thr 
                85                  90                  95      


Lys Val Asn Leu Leu Ser Ala Ile Lys Ser Pro Cys Gln Arg Glu Thr 
            100                 105                 110         


Pro Glu Gly Ala Glu Ala Lys Pro Trp Tyr Glu Pro Ile Tyr Leu Gly 
        115                 120                 125             


Gly Val Phe Gln Leu Glu Lys Gly Asp Arg Leu Ser Ala Glu Ile Asn 
    130                 135                 140                 


Arg Pro Asp Tyr Leu Asp Phe Ala Glu Ser Gly Gln Val Tyr Phe Gly 
145                 150                 155                 160 


Ile Ile Ala Leu 
                


<210>  29
<211>  182
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  conjugate

<400>  29

Met Arg Phe Pro Ser Ile Phe Thr Ala Val Leu Phe Ala Ala Ser Ser 
1               5                   10                  15      


Ala Leu Ala Cys Asn Gly Arg Cys Gly Val Arg Ser Ser Ser Arg Thr 
            20                  25                  30          


Pro Ser Asp Lys Pro Val Ala His Val Val Ala Asn Pro Gln Ala Glu 
        35                  40                  45              


Gly Gln Leu Gln Trp Leu Asn Arg Arg Ala Asn Ala Leu Leu Ala Asn 
    50                  55                  60                  


Gly Val Glu Leu Arg Asp Asn Gln Leu Val Val Pro Ser Glu Gly Leu 
65                  70                  75                  80  


Tyr Leu Ile Tyr Ser Gln Val Leu Phe Lys Gly Gln Gly Cys Pro Ser 
                85                  90                  95      


Thr His Val Leu Leu Thr His Thr Ile Ser Arg Ile Ala Val Ser Tyr 
            100                 105                 110         


Gln Thr Lys Val Asn Leu Leu Ser Ala Ile Lys Ser Pro Cys Gln Arg 
        115                 120                 125             


Glu Thr Pro Glu Gly Ala Glu Ala Lys Pro Trp Tyr Glu Pro Ile Tyr 
    130                 135                 140                 


Leu Gly Gly Val Phe Gln Leu Glu Lys Gly Asp Arg Leu Ser Ala Glu 
145                 150                 155                 160 


Ile Asn Arg Pro Asp Tyr Leu Asp Phe Ala Glu Ser Gly Gln Val Tyr 
                165                 170                 175     


Phe Gly Ile Ile Ala Leu 
            180         


<210>  30
<211>  564
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  conjugate

<400>  30
catatgcggg cgaaactcct aggaatagtc ctgacaaccc ctatcgcgat cagctctttt       60

gcgtcgacgt gcaacggccg ttgtggcctc agatcatctt ctcaaaattc gagtgacaag      120

cctgtagccc acgtcgtagc aaaccaccaa gtggaggagc agctggagtg gctgagccag      180

cgcgccaacg ccctcctggc caacggcatg gatctcaaag acaaccaact agtggtgcca      240

gccgatgggt tgtaccttgt ctactcccag gttctcttca agggacaagg ctgccccgac      300

tacgtgctcc tcacccacac cgtcagccga tttgctatct cataccagga gaaagtcaac      360

ctcctctctg ccgtcaagag cccctgcccc aaggacaccc ctgagggggc tgagctcaaa      420

ccctggtatg agcccatata cctgggagga gtcttccagc tggagaaggg ggaccaactc      480

agcgctgagg tcaatctgcc caagtactta gactttgcgg agtccgggca ggtctacttt      540

ggagtcattg ctctgtgagg atcc                                             564


<210>  31
<211>  505
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  conjugate

<400>  31
caccatgagc tgcaacggcc gttgcggcct cagatcatct tctcaaaatt cgagtgacaa       60

gcctgtagcc cacgtcgtag caaaccacca agtggaggag cagctggagt ggctgagcca      120

gcgcgccaac gccctcctgg ccaacggcat ggatctcaaa gacaaccaac tagtggtgcc      180

agccgatggg ttgtaccttg tctactccca ggttctcttc aagggacaag gctgccccga      240

ctacgtgctc ctcacccaca ccgtcagccg atttgctatc tcataccagg agaaagtcaa      300

cctcctctct gccgtcaaga gcccctgccc caaggacacc cctgaggggg ctgagctcaa      360

accctggtat gagcccatat acctgggagg agtcttccag ctggagaagg gggaccaact      420

cagcgctgag gtcaatctgc ccaagtactt agactttgcg gagtccgggc aggtctactt      480

tggagtcatt gctctgtgag gatcc                                            505


<210>  32
<211>  508
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  conjugate

<400>  32
caccatgagc tgcaacggcc gttgcggcgt cagatcatct tctcgaaccc cgagtgacaa       60

gcctgtagcc catgttgtag caaaccctca agctgagggg cagctccagt ggctgaaccg      120

ccgggccaat gccctcctgg ccaatggcgt ggagctgaga gataaccagc tggtggtgcc      180

atcagagggc ctgtacctca tctactccca ggtcctcttc aagggccaag gctgcccctc      240

cacccatgtg ctcctcaccc acaccatcag ccgcatcgcc gtctcctacc agaccaaggt      300

caacctcctc tctgccatca agagcccctg ccagagggag accccagagg gggctgaggc      360

caagccctgg tatgagccca tctatctggg aggggtcttc cagctggaga agggtgaccg      420

actcagcgct gagatcaatc ggcccgacta tctcgacttt gccgagtctg ggcaggtcta      480

ctttgggatc attgccctgt gaggatcc                                         508


<210>  33
<211>  507
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  conjugate

<400>  33
catatgagtt gcaacggccg ttgcggcgtc agatcatctt ctcgaacccc gagtgacaag       60

cctgtagccc atgttgtagc aaaccctcaa gctgaggggc agctccagtg gctgaaccgc      120

cgggccaatg ccctcctggc caatggcgtg gagctgagag ataaccagct ggtggtgcca      180

tcagagggcc tgtacctcat ctactcccag gtcctcttca agggccaagg ctgcccctcc      240

acccatgtgc tcctcaccca caccatcagc cgcatcgccg tctcctacca gaccaaggtc      300

aacctcctct ctgccatcaa gagcccctgc cagagggaga ccccagaggg ggctgaggcc      360

aagccctggt atgagcccat ctatctggga ggggtcttcc agctggagaa gggtgaccga      420

ctcagcgctg agatcaatcg gcccgactat ctcgactttg ccgagtctgg gcaggtctac      480

tttgggatca ttgccctgtg aggatcc                                          507


<210>  34
<211>  566
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  conjugate

<400>  34
ggatccaaac gatgagattc ccttctattt tcactgctgt tttgttcgct gcttcttctg       60

ctttggcttg taacggtaga tgtggtgtta gatcttcttc tagaactcct tctgataagc      120

ctgttgctca tgttgttgct aaccctcaag ctgaaggtca attgcaatgg ttgaacagaa      180

gagctaatgc tttgttggct aatggtgttg aattgagaga taatcaattg gttgttccat      240

ctgaaggttt gtacttgatc tattctcaag ttttgttcaa gggtcaaggt tgtccttcta      300

ctcatgtttt gttgactcat actatttcta gaatcgctgt ttcttatcaa actaaggtta      360

atttgctgtc tgctattaag tctccatgtc aaagagaaac tcctgaaggt gctgaagcta      420

agccatggta cgaaccaatc tatttgggtg gtgtttttca attggaaaag ggtgacagat      480

tgtctgctga aattaataga ccagattatt tggatttcgc tgaatctggt caagtttact      540

ttggtattat tgctttgtaa gaattc                                           566


<210>  35
<211>  4
<212>  PRT
<213>  Homo sapiens

<400>  35

Asp Gly Arg Cys 
1               


<210>  36
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  acetyl-Ciso

<400>  36

Asp Gly Arg Cys Lys 
1               5   


<210>  37
<211>  15
<212>  PRT
<213>  Mus musculus

<400>  37

Cys Asn Gly Arg Cys Gly Leu Arg Ser Ser Ser Gln Asn Ser Ser 
1               5                   10                  15  


<210>  38
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  38

Cys Asp Gly Arg Cys Gly 
1               5       


<210>  39
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  39

Cys Asn Gly Arg Cys Gly Leu Arg Ser Ser Ser Gln Asn Ser Ser Asp 
1               5                   10                  15      


<210>  40
<211>  28
<212>  PRT
<213>  Homo sapiens

<400>  40

Met Arg Ala Lys Leu Leu Gly Ile Val Leu Thr Thr Pro Ile Ala Ile 
1               5                   10                  15      


Ser Ser Phe Ala Ser Thr Cys Asn Gly Arg Cys Gly 
            20                  25              


<210>  41
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sequence


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Ciso or acetyl-Ciso or iso

<400>  41

Asp Gly Arg Cys 
1               


<210>  42
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sequence


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  acetylated

<400>  42

Cys Asn Gly Arg Cys Gly Val Arg Tyr 
1               5                   


<210>  43
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sequence

<400>  43

Met Arg Phe Pro Ser Ile Phe Thr Ala Val Leu Phe Ala Ala Ser Ser 
1               5                   10                  15      


Ala Leu Ala Cys Asn Gly Arg Cys Gly 
            20                  25  


