                         SEQUENCE LISTING

<110>  Novo Nordisk A/S
 
<120>  Plasmid comprising alopecia antigen

<130>  200002WO01

<160>  41    

<170>  PatentIn version 3.5

<210>  1
<211>  118
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  wt MART1 full length

<400>  1

Met Pro Arg Glu Asp Ala His Phe Ile Tyr Gly Tyr Pro Lys Lys Gly 
1               5                   10                  15      


His Gly His Ser Tyr Thr Thr Ala Glu Glu Ala Ala Gly Ile Gly Ile 
            20                  25                  30          


Leu Thr Val Ile Leu Gly Val Leu Leu Leu Ile Gly Cys Trp Tyr Cys 
        35                  40                  45              


Arg Arg Arg Asn Gly Tyr Arg Ala Leu Met Asp Lys Ser Leu His Val 
    50                  55                  60                  


Gly Thr Gln Cys Ala Leu Thr Arg Arg Cys Pro Gln Glu Gly Phe Asp 
65                  70                  75                  80  


His Arg Asp Ser Lys Val Ser Leu Gln Glu Lys Asn Cys Glu Pro Val 
                85                  90                  95      


Val Pro Asn Ala Pro Pro Ala Tyr Glu Lys Leu Ser Ala Glu Gln Ser 
            100                 105                 110         


Pro Pro Pro Tyr Ser Pro 
        115             


<210>  2
<211>  575
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  wt gp100 full length

<400>  2

Met Asp Leu Val Leu Lys Arg Cys Leu Leu His Leu Ala Val Ile Gly 
1               5                   10                  15      


Ala Leu Leu Ala Val Gly Ala Thr Lys Gly Ser Gln Val Trp Gly Gly 
            20                  25                  30          


Gln Pro Val Tyr Pro Gln Glu Thr Asp Asp Ala Cys Ile Phe Pro Asp 
        35                  40                  45              


Gly Gly Pro Cys Pro Ser Gly Ser Trp Ser Gln Lys Arg Ser Phe Val 
    50                  55                  60                  


Tyr Val Trp Lys Thr Trp Gly Gln Tyr Trp Gln Val Leu Gly Gly Pro 
65                  70                  75                  80  


Val Ser Gly Leu Ser Ile Gly Thr Gly Arg Ala Met Leu Gly Thr His 
                85                  90                  95      


Thr Met Glu Val Thr Val Tyr His Arg Arg Gly Ser Arg Ser Tyr Val 
            100                 105                 110         


Pro Leu Ala His Ser Ser Ser Ala Phe Thr Ile Thr Asp Gln Val Pro 
        115                 120                 125             


Phe Ser Val Ser Val Ser Gln Leu Arg Ala Leu Asp Gly Gly Asn Lys 
    130                 135                 140                 


His Phe Leu Arg Asn Gln Pro Leu Thr Phe Ala Leu Gln Leu His Asp 
145                 150                 155                 160 


Pro Ser Gly Tyr Leu Ala Glu Ala Asp Leu Ser Tyr Thr Trp Asp Phe 
                165                 170                 175     


Gly Asp Ser Ser Gly Thr Leu Ile Ser Arg Ala Leu Val Val Thr His 
            180                 185                 190         


Thr Tyr Leu Glu Pro Gly Pro Val Thr Ala Gln Val Val Leu Gln Ala 
        195                 200                 205             


Ala Ile Pro Leu Thr Ser Cys Gly Ser Ser Pro Val Pro Gly Thr Thr 
    210                 215                 220                 


Asp Gly His Arg Pro Thr Ala Glu Ala Pro Asn Thr Thr Ala Gly Gln 
225                 230                 235                 240 


Val Pro Thr Thr Glu Val Val Gly Thr Thr Pro Gly Gln Ala Pro Thr 
                245                 250                 255     


Ala Glu Pro Ser Gly Thr Thr Ser Val Gln Val Pro Thr Thr Glu Val 
            260                 265                 270         


Ile Ser Thr Ala Pro Val Gln Met Pro Thr Ala Glu Ser Thr Gly Met 
        275                 280                 285             


Thr Pro Glu Lys Val Pro Val Ser Glu Val Met Gly Thr Thr Leu Ala 
    290                 295                 300                 


Glu Met Ser Thr Pro Glu Ala Thr Gly Met Thr Pro Ala Glu Val Ser 
305                 310                 315                 320 


Ile Val Val Leu Ser Gly Thr Thr Ala Ala Gln Val Thr Thr Thr Glu 
                325                 330                 335     


Trp Val Glu Thr Thr Ala Arg Glu Leu Pro Ile Pro Glu Pro Glu Gly 
            340                 345                 350         


Pro Asp Ala Ser Ser Ile Met Ser Thr Glu Ser Ile Thr Gly Ser Leu 
        355                 360                 365             


Gly Pro Leu Leu Asp Gly Thr Ala Thr Leu Arg Leu Val Lys Arg Gln 
    370                 375                 380                 


Val Pro Leu Asp Cys Val Leu Tyr Arg Tyr Gly Ser Phe Ser Val Thr 
385                 390                 395                 400 


Leu Asp Ile Val Gln Gly Ile Glu Ser Ala Glu Ile Leu Gln Ala Val 
                405                 410                 415     


Pro Ser Gly Glu Gly Asp Ala Phe Glu Leu Thr Val Ser Cys Gln Gly 
            420                 425                 430         


Gly Leu Pro Lys Glu Ala Cys Met Glu Ile Ser Ser Pro Gly Cys Gln 
        435                 440                 445             


Pro Pro Ala Gln Arg Leu Cys Gln Pro Val Leu Pro Ser Pro Ala Cys 
    450                 455                 460                 


Gln Leu Val Leu His Gln Ile Leu Lys Gly Gly Ser Gly Thr Tyr Cys 
465                 470                 475                 480 


Leu Asn Val Ser Leu Ala Asp Thr Asn Ser Leu Ala Val Val Ser Thr 
                485                 490                 495     


Gln Leu Ile Met Pro Gly Gln Glu Ala Gly Leu Gly Gln Val Pro Leu 
            500                 505                 510         


Ile Val Gly Ile Leu Leu Val Leu Met Ala Val Val Leu Ala Ser Leu 
        515                 520                 525             


Ile Tyr Arg Arg Arg Leu Met Lys Gln Asp Phe Ser Val Pro Gln Leu 
    530                 535                 540                 


Pro His Ser Ser Ser His Trp Leu Arg Leu Pro Arg Ile Phe Cys Ser 
545                 550                 555                 560 


Cys Pro Ile Gly Glu Asn Ser Pro Leu Leu Ser Gly Gln Gln Val 
                565                 570                 575 


<210>  3
<211>  19
<212>  PRT
<213>  Synthetic


<220>
<221>  MISC_FEATURE
<223>  gp100(149-167)

<400>  3

Phe Val Tyr Val Trp Lys Thr Trp Gly Gln Tyr Trp Gln Val Leu Gly 
1               5                   10                  15      


Gly Pro Val 
            


<210>  4
<211>  19
<212>  PRT
<213>  Synthetic


<220>
<221>  MISC_FEATURE
<223>  gp100(204-222)

<400>  4

Ser Ser Ala Phe Thr Ile Thr Asp Gln Val Pro Phe Ser Val Ser Val 
1               5                   10                  15      


Ser Gln Leu 
            


<210>  5
<211>  19
<212>  PRT
<213>  Synthetic


<220>
<221>  MISC_FEATURE
<223>  gp100(275-293)

<400>  5

Val Val Thr His Thr Tyr Leu Glu Pro Gly Pro Val Thr Ala Gln Val 
1               5                   10                  15      


Val Leu Gln 
            


<210>  6
<211>  19
<212>  PRT
<213>  Synthetic


<220>
<221>  MISC_FEATURE
<223>  MART1 (22-40)

<400>  6

Thr Thr Ala Glu Glu Ala Ala Gly Ile Gly Ile Leu Thr Val Ile Leu 
1               5                   10                  15      


Gly Val Leu 
            


<210>  7
<211>  76
<212>  PRT
<213>  Synthetic


<220>
<221>  MISC_FEATURE
<223>  gp100/MART1 minigene

<400>  7

Phe Val Tyr Val Trp Lys Thr Trp Gly Gln Tyr Trp Gln Val Leu Gly 
1               5                   10                  15      


Gly Pro Val Ser Ser Ala Phe Thr Ile Thr Asp Gln Val Pro Phe Ser 
            20                  25                  30          


Val Ser Val Ser Gln Leu Val Val Thr His Thr Tyr Leu Glu Pro Gly 
        35                  40                  45              


Pro Val Thr Ala Gln Val Val Leu Gln Thr Thr Ala Glu Glu Ala Ala 
    50                  55                  60                  


Gly Ile Gly Ile Leu Thr Val Ile Leu Gly Val Leu 
65                  70                  75      


<210>  8
<211>  6270
<212>  DNA
<213>  synthetic


<220>
<221>  misc_feature
<223>  gp100/MART1 plasmid (AA plasmid)

<400>  8
gactcttcgc gatgtacggg ccagatatac gcgttgacat tgattattga ctagttatta       60

atagtaatca attacggggt cattagttca tagcccatat atggagttcc gcgttacata      120

acttacggta aatggcccgc ctggctgacc gcccaacgac ccccgcccat tgacgtcaat      180

aatgacgtat gttcccatag taacgccaat agggactttc cattgacgtc aatgggtgga      240

ctatttacgg taaactgccc acttggcagt acatcaagtg tatcatatgc caagtacgcc      300

ccctattgac gtcaatgacg gtaaatggcc cgcctggcat tatgcccagt acatgacctt      360

atgggacttt cctacttggc agtacatcta cgtattagtc atcgctatta ccatggtgat      420

gcggttttgg cagtacatca atgggcgtgg atagcggttt gactcacggg gatttccaag      480

tctccacccc attgacgtca atgggagttt gttttggcac caaaatcaac gggactttcc      540

aaaatgtcgt aacaactccg ccccattgac gcaaatgggc ggtaggcgtg tacggtggga      600

ggtctatata agcagagctc tctggctaac tagagaaccc actgcttact ggcttatcga      660

aattaatacg actcactata gggagaccca agctggctag cgtttaaact taagcttggt      720

accgagctcg gatccactag tccagtgtgg tggaattctg cactgcagct cgcatctctc      780

cttcacgcgc ccgccgccct acctgaggcc gccatccacg ccggttgagt cgcgttctgc      840

cgcctcccgc ctgtggtgcc tcctgaactg cgtccgccgt ctaggtaagt ttaaagctca      900

ggtcgagacc gggcctttgt ccggcgctcc cttggagcct acctagactc agccggctct      960

ccacgctttg cctgaccctg cttgctcaac tctagttctc tcgttaactt aatgagacag     1020

atagaaactg gtcttgtaga aacagagtag tcgcctgctt ttctgccagg tgctgacttc     1080

tctcccctgg gcttttttct ttttctcagg ttgaaaagaa gaagacgaag aagacgaaga     1140

agacaaaccg tcgtcgacgc caccatggat gaccaacgcg acctcatctc taaccatgaa     1200

cagttgccca tactgggcaa ccgccctaga gagccagaaa ggtgcagccg tggagctctg     1260

tacaccggtg tctctgtcct ggtggctctg ctcttggctg ggcaggccac cactgcttac     1320

ttcctgtacc agcaacaggg ccgcctagac aagctgacca tcacctccca gaacctccag     1380

ctggagagcc tcaggatgaa gctgccattc gtgtacgtgt ggaagacctg gggccagtac     1440

tggcaggtgc tgggcggccc cgtgagcagc gccttcacca tcaccgacca ggtgcccttc     1500

agcgtgagcg tgagccagct ggtggtgacc cacacctacc tggagcccgg ccccgtgacc     1560

gcccaggtgg tgctccagac caccgccgag gaggccgccg gcatcggcat cctgaccgtg     1620

atcctgggcg tgctgggaag cggagtgaag cagacgttga attttgattt gttgaagttg     1680

gcgggggatg tggagagcaa tccggggccg atgccacctt ccggcttaag gcttcttccg     1740

ctcttactgc ccttgccttg gcttttagtg ctgaccccag gtcggccagc cgctggtctg     1800

tctacctgta aaactattga tatggaattg gttaagcgta agcgcattga ggcaatacga     1860

ggacagatct tgtcaaagct ccgacttgca tcgccccctt ctcagggtga ggtaccgcca     1920

ggacctttgc ccgaggcagt tctagccctt tataattcaa cccgcgacag agtcgcaggc     1980

gaaagcgccg acccagaacc tgaacctgag gctgactact acgccaagga ggtaacaagg     2040

gtcttgatgg tggacaggaa caatgcaata tacgagaaaa ccaaagacat ttctcactca     2100

atatatatgt tttttaacac ttccgacatt agagaagccg ttccagaacc acccttgcta     2160

agccgtgccg agctgcgact tcaacgcctg aagtccagtg tcgagcaaca cgtggagctg     2220

tatcaaaaat attccaacaa tagttggaga tatctgggaa atcggctcct aacacctact     2280

gacacgcctg agtggctgtc tttcgacgtt actggggtgg tacgacagtg gctgaaccaa     2340

ggcgatggaa tccagggatt taggttctcg gcgcatagct ccagcgacag taaagacaac     2400

aaactacatg tcgagattaa tgggatctca ccaaaaaggc gcggggatct ggggaccatt     2460

cacgatatga accggccctt cctcctgctc atggccactc cactggagag agcccagcat     2520

ctgcatagct cacggcatcg gcgtgctctc gatacaaact actgctttag ctctacagag     2580

aaaaattgct gcgtgagaca gctctatatc gatttcagga aagatctggg ctggaagtgg     2640

atacacgaac cgaagggcta tcacgctaac ttttgcctcg ggccctgccc ttacatctgg     2700

agtctggata cacagtacag taaggtcctc gcgctctaca accagcacaa ccccggagct     2760

agcgcttctc cttgttgtgt gcctcaggct ctggaaccgc tgcccatcgt gtactacgtg     2820

ggcagaaagc ccaaggtgga acagctgtcc aacatgatcg tgcgcagctg taagtgttcc     2880

tgataaacgc gtcgagcatg catctagggc ggccaattcc gcccctctcc cccccacccc     2940

tctccctccc ccccccctaa cgttactggc cgaagccgct tggaataagg ccggtgtgcg     3000

tttgtctata tgttattttc caccatattg ccgtcttttg gcaatgtgag ggcccggaaa     3060

cctggccctg tcttcttgac gagcattcct aggggtcttt cccctctcgc caaaggaatg     3120

caaggtctgt tgaatgtcgt gaaggaagca gttcctctgg aagcttcttg aagacaaaca     3180

acgtctgtag cgaccctttg caggcagcgg aaccccccac ctggcgacag gtgcctctgc     3240

ggccaaaagc cacgtgtata agatacacct gcaaaggcgg cacaacccca gtgccacgtt     3300

gtgagttgga tagttgtgga aagagtcaaa tggctctcct caagcgtatt caacaagggg     3360

ctgaaggatg cccagaaggt accccattgt atgggatctg atctggggcc tcggtgcaca     3420

tgctttacat gtgtttagtc gaggttaaaa aacgtctagg ccccccgaac cacggggacg     3480

tggttttcct ttgaaaaaca cgatgataat atggctgccg ctcccggcag cgccctgctg     3540

tgctgcctgc tgctgctgac cggcatgaga atcagcagag gccagtacag cagagaggac     3600

aacaactgca cccacttccc cgtgggccag agccacatgc tgctggagct gagaaccgcc     3660

ttcagccagg tgaagacctt cttccagacc aaggaccagc tggacaacat cctgctgacc     3720

gacagcctga tgcaggactt caagggctac ctgggctgcc aggccctgag cgagatgatc     3780

cagttctacc tggtggaggt gatgccccag gccgagaagc acggccccga gatcaaggag     3840

cacctgaaca gcctgggcga gaagctgaag accctgagaa tgagactgag aagatgccac     3900

agattcctgc cctgcgagaa caagagcaag gccgtggagc aggtgaagag cgacttcaac     3960

aagctccagg accagggcgt gtacaaggcc atgaacgagt tcgacatctt catcaactgc     4020

atcgaggcct acatgatgat caagatgaag agcgggagcg gcgctactaa cttcagcctg     4080

ctgaagcagg ctggagacgt ggaggagaac cctggaccta tgtacagtat gcagctagct     4140

tcctgcgtaa cgttaacctt ggtgttactt gtgaatagtg cccccacatc ttcatcgacc     4200

tcttcaagca ccgccgaagc tcaacagcag caacagcaac aacagcagca gcaacagcac     4260

ctggaacaac tgcttatgga ccttcaggaa ctcctcagcc ggatggaaaa ctatcgaaat     4320

ttgaaactcc cgagaatgct aaccttcaag ttttacctcc caaagcaggc cacagaactt     4380

aaggaccttc agtgtctgga ggatgagctc ggaccgctgc gtcatgtcct ggacctgacc     4440

cagtctaaaa gcttccagct ggaggatgct gagaacttca tcagcaacat aagagttact     4500

gtcgtgaagc tgaaaggttc agacaacacc ttcgagtgcc aatttgatga cgagtccgca     4560

actgtggttg actttctgcg cagatggatc gcattttgtc agtccattat ttctacttcc     4620

cctcagtgac tcgaggtcta gagggcccgt ttaaacccgc tgatcagcct cgactgtgcc     4680

ttcagttgcc agccatctgt tgtttgcccc tcccccgtgc cttccttgac cctggaaggt     4740

gccactccca ctgtcctttc ctaataaaat gaggaaattg catcgcattg tctgagtagg     4800

tgtcattcta ttctgggggg tggggtgggg caggacagca agggggagga ttgggaagac     4860

aatagcaggc atgctgggga tgcggtgggc tctatggctt ctactgggcg gttttatgga     4920

cagcaagcga accggaattg ccagctgggg cgccctctgg taaggttggg aagccctgca     4980

aagtaaactg gatggctttc tcgccgccaa ggatctgatg gcgcagggga tcaagctctg     5040

atcaagagac aggatgagga tcgtttcgca tggccaaaga agacaatatt gaaatgcaag     5100

gtaccgttct tgaaacgttg cctaatacca tgttccgcgt agagttagaa aacggtcacg     5160

tggttactgc acacatctcc ggtaaaatgc gcaaaaacta catccgcatc ctgacgggcg     5220

acaaagtgac tgttgaactg accccgtacg acctgagcaa aggccgcatt gtcttccgta     5280

gtcgctgata aattattaac gcttacaatt tcctgatgcg gtattttctc cttacgcatc     5340

tgtgcggtat ttcacaccgc atacaggtgg cacttttcgg ggaaatgtgc gcggaacccc     5400

tatttgttta tttttctaaa tacattcaaa tatgtatccg ctcatgagac aataaccctg     5460

ataaatgctt caataatagc acgtgctaaa acttcatttt taatttaaaa ggatctaggt     5520

gaagatcctt tttgataatc tcatgaccaa aatcccttaa cgtgagtttt cgttccactg     5580

agcgtcagac cccgtagaaa agatcaaagg atcttcttga gatccttttt ttctgcgcgt     5640

aatctgctgc ttgcaaacaa aaaaaccacc gctaccagcg gtggtttgtt tgccggatca     5700

agagctacca actctttttc cgaaggtaac tggcttcagc agagcgcaga taccaaatac     5760

tgttcttcta gtgtagccgt agttaggcca ccacttcaag aactctgtag caccgcctac     5820

atacctcgct ctgctaatcc tgttaccagt ggctgctgcc agtggcgata agtcgtgtct     5880

taccgggttg gactcaagac gatagttacc ggataaggcg cagcggtcgg gctgaacggg     5940

gggttcgtgc acacagccca gcttggagcg aacgacctac accgaactga gatacctaca     6000

gcgtgagcta tgagaaagcg ccacgcttcc cgaagggaga aaggcggaca ggtatccggt     6060

aagcggcagg gtcggaacag gagagcgcac gagggagctt ccagggggaa acgcctggta     6120

tctttatagt cctgtcgggt ttcgccacct ctgacttgag cgtcgatttt tgtgatgctc     6180

gtcagggggg cggagcctat ggaaaaacgc cagcaacgcg gcctttttac ggttcctggg     6240

cttttgctgg ccttttgctc acatgttctt                                      6270


<210>  9
<211>  6290
<212>  DNA
<213>  synthetic


<220>
<221>  misc_feature
<223>  Human plasmid

<400>  9
gactcttcgc gatgtacggg ccagatatac gcgttgacat tgattattga ctagttatta       60

atagtaatca attacggggt cattagttca tagcccatat atggagttcc gcgttacata      120

acttacggta aatggcccgc ctggctgacc gcccaacgac ccccgcccat tgacgtcaat      180

aatgacgtat gttcccatag taacgccaat agggactttc cattgacgtc aatgggtgga      240

ctatttacgg taaactgccc acttggcagt acatcaagtg tatcatatgc caagtacgcc      300

ccctattgac gtcaatgacg gtaaatggcc cgcctggcat tatgcccagt acatgacctt      360

atgggacttt cctacttggc agtacatcta cgtattagtc atcgctatta ccatggtgat      420

gcggttttgg cagtacatca atgggcgtgg atagcggttt gactcacggg gatttccaag      480

tctccacccc attgacgtca atgggagttt gttttggcac caaaatcaac gggactttcc      540

aaaatgtcgt aacaactccg ccccattgac gcaaatgggc ggtaggcgtg tacggtggga      600

ggtctatata agcagagctc tctggctaac tagagaaccc actgcttact ggcttatcga      660

aattaatacg actcactata gggagaccca agctggctag cgtttaaact taagcttggt      720

accgagctcg gatccactag tccagtgtgg tggaattctg cactgcagct cgcatctctc      780

cttcacgcgc ccgccgccct acctgaggcc gccatccacg ccggttgagt cgcgttctgc      840

cgcctcccgc ctgtggtgcc tcctgaactg cgtccgccgt ctaggtaagt ttaaagctca      900

ggtcgagacc gggcctttgt ccggcgctcc cttggagcct acctagactc agccggctct      960

ccacgctttg cctgaccctg cttgctcaac tctaggtaag ttaatgagac agatagaaac     1020

tggtcttgta gaaacagagt agtcgcctgc ttttctgcca ggtgctgact tctctcccct     1080

gggctttttt ctttttctca ggttgaaaag aagaagacga agaagacgaa gaagacaaac     1140

cgtcgtcgac tgccatgcgc cgctgattaa cgccgccacc atggcccacc gacgcagatc     1200

cagaagctgc cgtgaggacc agaagcccgt gatggatgat cagagggacc ttatctctaa     1260

caatgaacaa ctgccaatgc tcggcagacg gcctggggcc ccggagagca agtgcagcag     1320

aggagccttg tacacggggt tctccatttt agtgactctc cttctcgccg gccaagctac     1380

caccgcctac tttctgtacc aacagcaagg cagactagac aaactgacaa tcacaagcca     1440

gaaccttcag ctggagtctc tgcggatgaa gctgcccttc gtgtacgtgt ggaagacctg     1500

gggccagtac tggcaggtgc tgggcggccc cgtgagcagc gccttcacca tcaccgacca     1560

ggtgcccttc agcgtgagcg tgagccagct ggtggtgacc cacacctacc tggagcccgg     1620

ccccgtgacc gcccaggtgg tgctccagac caccgccgag gaggccgccg gcatcggcat     1680

cctgaccgtg atcctgggcg tgctgggaag cggagtgaag cagacgttga attttgattt     1740

gttgaagttg gcgggggatg tggagagcaa tccggggccg atgcccccta gtggcctcag     1800

acttttgtta ttgttattac cgcttttatg gctcttggtg ctgacaccgg gccgtccggc     1860

tgctggcttg tcgacttgta agacaattga tatggaattg gtgaaacgaa aacggattga     1920

ggccatccga ggacagattt tgagcaagct gcggcttgcc tcgccaccct cgcaagggga     1980

agtcccaccc ggacctctac cagaagcagt cctagcgctg tacaacagta caagagatag     2040

agtggccggg gaatccgcag aaccagagcc tgagcctgaa gccgattatt atgcaaagga     2100

agtgactagg gtcctgatgg tcgagaccca taacgaaatc tacgacaaat tcaaacaaag     2160

tacccactct atctacatgt tcttcaacac cagtgagcta agagaagccg tgcccgaacc     2220

tgtgcttctt tcccgcgcag aactccgcct cttgagactc aaattgaaag ttgaacaaca     2280

cgtagagctt taccagaaat actctaataa ttcatggcga tatctttcta atcgtctcct     2340

cgccccatct gacagccctg aatggctctc cttcgacgtt acgggagttg tgcgccagtg     2400

gctcagcaga ggcggagaga tagagggctt tcggctgagc gcacatagct ctagcgactc     2460

aagggacaac acattgcaag tggatattaa cggttttaca actggacgga gaggggacct     2520

ggcgaccatc cacggcatga atagaccttt cctgctgctg atggctactc ccctggagag     2580

ggcacagcac ttacagtctt ccagacaccg gcgcgccctg gatacaaact actgcttcag     2640

ctccaccgaa aagaactgtt gcgtgcggca gctgtacatt gacttcagaa aggatctggg     2700

ctggaagtgg attcatgagc ccaaggggta tcatgccaac ttctgtcttg ggccatgccc     2760

atacatctgg tcactggata cccagtactc caaagttctg gccttgtaca atcaacacaa     2820

ccctggagct tccgccgctc cttgctgtgt gccccaagcc ctagagcccc tgcccatcgt     2880

ttattatgtc ggacgcaagc ccaaagtaga acagctatca aatatgatcg tgagaagctg     2940

caagtgtagc tgataaacgc gtcgagcatg catctagggc ggccaattcc gcccctctcc     3000

cccccacccc tctccctccc ccccccctaa cgttactggc cgaagccgct tggaataagg     3060

ccggtgtgcg tttgtctata tgttattttc caccatattg ccgtcttttg gcaatgtgag     3120

ggcccggaaa cctggccctg tcttcttgac gagcattcct aggggtcttt cccctctcgc     3180

caaaggaatg caaggtctgt tgaatgtcgt gaaggaagca gttcctctgg aagcttcttg     3240

aagacaaaca acgtctgtag cgaccctttg tagacagcgg aaccccccac ctggcgatag     3300

atgcctctgc ggccaaaagc cacgtgtata agatacacct gcaaaggcgg cacaacccca     3360

gtgccacgtt gtgagttgga tagttgtgga aagagtcaaa tggctctcct caagcgtatt     3420

caacaagggg ctgaaggatg cccagaaggt accccattgt atgggatctg atctggggcc     3480

tcggtgcaca tgctttacat gtgtttagtc gaggttaaaa aacgtctagg ccccccgaac     3540

cacggggacg tggttttcct ttgaaaaaca cgatgataat atgatgcaca gctcagcact     3600

gctctgttgc ctggtcctcc tgactggggt gagggccagc ccaggccagg gcacccagtc     3660

tgagaacagc tgcacccact tcccaggcaa cctgcctaac atgcttcgag atctccgaga     3720

tgccttcagc agagtgaaga ctttctttca aatgaaggat cagctggaca acttgttgtt     3780

aaaggagtcc ttgctggagg actttaaggg ttacctgggt tgccaagcct tgtctgagat     3840

gatccagttt tacctggagg aggtgatgcc ccaagctgag aaccaagacc cagacatcaa     3900

ggcgcatgtg aactccctgg gggagaacct gaagaccctc aggctgaggc tacggcgctg     3960

tcatcgattt cttccctgtg aaaacaagag caaggccgtg gagcaggtga agaatgcctt     4020

taataagctc caagagaaag gcatctacaa agccatgagt gagtttgaca tcttcatcaa     4080

ctacatagaa gcctacatga caatgaagat acgaaacggg agcggcgcta ctaacttcag     4140

cctgctgaag caggctggag acgtggagga gaaccctgga cctatgtaca gaatgcagct     4200

gctgagctgc atcgccctga gcctggccct ggtgaccaac agcgcaccca cgtcctctag     4260

caccaagaag acccagttac agttggagca tctactttta gacctgcaaa tgattttgaa     4320

cggcatcaac aactacaaga atcctaaact tactcgcatg cttaccttca aattttacat     4380

gcccaagaag gccaccgaac tgaagcactt gcaatgtctg gaggaagaac tcaagccgct     4440

ggaggaagtt ctcaacctcg cgcagtccaa gaatttccac ctccggccaa gagacctgat     4500

cagtaacatt aatgtgatag tgctggagct gaagggaagc gagactacat ttatgtgcga     4560

gtacgccgat gaaaccgcta caatcgtcga gttcctgaat agatggatca cattttgcca     4620

gtcaattatc tctactctga catgataact cgaggtctag agggcccgtt taaacccgct     4680

gatcagcctc gactgtgcct tctagttgcc agccatctgt tgtttgcccc tcccccgtgc     4740

cttccttgac cctggaaggt gccactccca ctgtcctttc ctaataaaat gaggaaattg     4800

catcgcattg tctgagtagg tgtcattcta ttctgggggg tggggtgggg caggacagca     4860

agggggagga ttgggaagac aatagcaggc atgctgggga tgcggtgggc tctatggctt     4920

ctactgggcg gttttatgga cagcaagcga accggaattg ccagctgggg cgccctctgg     4980

taaggttggg aagccctgca aagtaaactg gatggctttc tcgccgccaa ggatctgatg     5040

gcgcagggga tcaagctctg atcaagagac aggatgagga tcgtttcgca tggccaaaga     5100

agacaatatt gaaatgcaag gtaccgttct tgaaacgttg cctaatacca tgttccgcgt     5160

agagttagaa aacggtcacg tggttactgc acacatctcc ggtaaaatgc gcaaaaacta     5220

catccgcatc ctgacgggcg acaaagtgac tgttgaactg accccgtacg acctgagcaa     5280

aggccgcatt gtcttccgta gtcgctgata aattattaac gcttacaatt tcctgatgcg     5340

gtattttctc cttacgcatc tgtgcggtat ttcacaccgc atacaggtgg cacttttcgg     5400

ggaaatgtgc gcggaacccc tatttgttta tttttctaaa tacattcaaa tatgtatccg     5460

ctcatgagac aataaccctg ataaatgctt caataatagc acgtgctaaa acttcatttt     5520

taatttaaaa ggatctaggt gaagatcctt tttgataatc tcatgaccaa aatcccttaa     5580

cgtgagtttt cgttccactg agcgtcagac cccgtagaaa agatcaaagg atcttcttga     5640

gatccttttt ttctgcgcgt aatctgctgc ttgcaaacaa aaaaaccacc gctaccagcg     5700

gtggtttgtt tgccggatca agagctacca actctttttc cgaaggtaac tggcttcagc     5760

agagcgcaga taccaaatac tgttcttcta gtgtagccgt agttaggcca ccacttcaag     5820

aactctgtag caccgcctac atacctcgct ctgctaatcc tgttaccagt ggctgctgcc     5880

agtggcgata agtcgtgtct taccgggttg gactcaagac gatagttacc ggataaggcg     5940

cagcggtcgg gctgaacggg gggttcgtgc acacagccca gcttggagcg aacgacctac     6000

accgaactga gatacctaca gcgtgagcta tgagaaagcg ccacgcttcc cgaagggaga     6060

aaggcggaca ggtatccggt aagcggcagg gtcggaacag gagagcgcac gagggagctt     6120

ccagggggaa acgcctggta tctttatagt cctgtcgggt ttcgccacct ctgacttgag     6180

cgtcgatttt tgtgatgctc gtcagggggg cggagcctat ggaaaaacgc cagcaacgcg     6240

gcctttttac ggttcctggg cttttgctgg ccttttgctc acatgttctt                6290


<210>  10
<211>  180
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<223>  mIL10

<400>  10

Ala Ala Ala Pro Gly Ser Ala Leu Leu Cys Cys Leu Leu Leu Leu Thr 
1               5                   10                  15      


Gly Met Arg Ile Ser Arg Gly Gln Tyr Ser Arg Glu Asp Asn Asn Cys 
            20                  25                  30          


Thr His Phe Pro Val Gly Gln Ser His Met Leu Leu Glu Leu Arg Thr 
        35                  40                  45              


Ala Phe Ser Gln Val Lys Thr Phe Phe Gln Thr Lys Asp Gln Leu Asp 
    50                  55                  60                  


Asn Ile Leu Leu Thr Asp Ser Leu Met Gln Asp Phe Lys Gly Tyr Leu 
65                  70                  75                  80  


Gly Cys Gln Ala Leu Ser Glu Met Ile Gln Phe Tyr Leu Val Glu Val 
                85                  90                  95      


Met Pro Gln Ala Glu Lys His Gly Pro Glu Ile Lys Glu His Leu Asn 
            100                 105                 110         


Ser Leu Gly Glu Lys Leu Lys Thr Leu Arg Met Arg Leu Arg Arg Cys 
        115                 120                 125             


His Arg Phe Leu Pro Cys Glu Asn Lys Ser Lys Ala Val Glu Gln Val 
    130                 135                 140                 


Lys Ser Asp Phe Asn Lys Leu Gln Asp Gln Gly Val Tyr Lys Ala Met 
145                 150                 155                 160 


Asn Glu Phe Asp Ile Phe Ile Asn Cys Ile Glu Ala Tyr Met Met Ile 
                165                 170                 175     


Lys Met Lys Ser 
            180 


<210>  11
<211>  178
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  hIL10

<400>  11

Met His Ser Ser Ala Leu Leu Cys Cys Leu Val Leu Leu Thr Gly Val 
1               5                   10                  15      


Arg Ala Ser Pro Gly Gln Gly Thr Gln Ser Glu Asn Ser Cys Thr His 
            20                  25                  30          


Phe Pro Gly Asn Leu Pro Asn Met Leu Arg Asp Leu Arg Asp Ala Phe 
        35                  40                  45              


Ser Arg Val Lys Thr Phe Phe Gln Met Lys Asp Gln Leu Asp Asn Leu 
    50                  55                  60                  


Leu Leu Lys Glu Ser Leu Leu Glu Asp Phe Lys Gly Tyr Leu Gly Cys 
65                  70                  75                  80  


Gln Ala Leu Ser Glu Met Ile Gln Phe Tyr Leu Glu Glu Val Met Pro 
                85                  90                  95      


Gln Ala Glu Asn Gln Asp Pro Asp Ile Lys Ala His Val Asn Ser Leu 
            100                 105                 110         


Gly Glu Asn Leu Lys Thr Leu Arg Leu Arg Leu Arg Arg Cys His Arg 
        115                 120                 125             


Phe Leu Pro Cys Glu Asn Lys Ser Lys Ala Val Glu Gln Val Lys Asn 
    130                 135                 140                 


Ala Phe Asn Lys Leu Gln Glu Lys Gly Ile Tyr Lys Ala Met Ser Glu 
145                 150                 155                 160 


Phe Asp Ile Phe Ile Asn Tyr Ile Glu Ala Tyr Met Thr Met Lys Ile 
                165                 170                 175     


Arg Asn 
        


<210>  12
<211>  169
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<223>  mIL2

<400>  12

Met Tyr Ser Met Gln Leu Ala Ser Cys Val Thr Leu Thr Leu Val Leu 
1               5                   10                  15      


Leu Val Asn Ser Ala Pro Thr Ser Ser Ser Thr Ser Ser Ser Thr Ala 
            20                  25                  30          


Glu Ala Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln His Leu 
        35                  40                  45              


Glu Gln Leu Leu Met Asp Leu Gln Glu Leu Leu Ser Arg Met Glu Asn 
    50                  55                  60                  


Tyr Arg Asn Leu Lys Leu Pro Arg Met Leu Thr Phe Lys Phe Tyr Leu 
65                  70                  75                  80  


Pro Lys Gln Ala Thr Glu Leu Lys Asp Leu Gln Cys Leu Glu Asp Glu 
                85                  90                  95      


Leu Gly Pro Leu Arg His Val Leu Asp Leu Thr Gln Ser Lys Ser Phe 
            100                 105                 110         


Gln Leu Glu Asp Ala Glu Asn Phe Ile Ser Asn Ile Arg Val Thr Val 
        115                 120                 125             


Val Lys Leu Lys Gly Ser Asp Asn Thr Phe Glu Cys Gln Phe Asp Asp 
    130                 135                 140                 


Glu Ser Ala Thr Val Val Asp Phe Leu Arg Arg Trp Ile Ala Phe Cys 
145                 150                 155                 160 


Gln Ser Ile Ile Ser Thr Ser Pro Gln 
                165                 


<210>  13
<211>  133
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  hIL2

<400>  13

Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His 
1               5                   10                  15      


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            20                  25                  30          


Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys 
        35                  40                  45              


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys 
    50                  55                  60                  


Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu 
65                  70                  75                  80  


Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu 
                85                  90                  95      


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            100                 105                 110         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile 
        115                 120                 125             


Ile Ser Thr Leu Thr 
    130             


<210>  14
<211>  219
<212>  DNA
<213>  Escherichia coli


<220>
<221>  misc_feature
<223>  wt E.coli infA

<400>  14
atggccaaag aagacaatat tgaaatgcaa ggtaccgttc ttgaaacgtt gcctaatacc       60

atgttccgcg tagagttaga aaacggtcac gtggttactg cacacatctc cggtaaaatg      120

cgcaaaaact acatccgcat cctgacgggc gacaaagtga ctgttgaact gaccccgtac      180

gacctgagca aaggccgcat tgtcttccgt agtcgctga                             219


<210>  15
<211>  72
<212>  PRT
<213>  Escherichia coli


<220>
<221>  MISC_FEATURE
<223>  wt E.coli IF1

<400>  15

Met Ala Lys Glu Asp Asn Ile Glu Met Gln Gly Thr Val Leu Glu Thr 
1               5                   10                  15      


Leu Pro Asn Thr Met Phe Arg Val Glu Leu Glu Asn Gly His Val Val 
            20                  25                  30          


Thr Ala His Ile Ser Gly Lys Met Arg Lys Asn Tyr Ile Arg Ile Leu 
        35                  40                  45              


Thr Gly Asp Lys Val Thr Val Glu Leu Thr Pro Tyr Asp Leu Ser Lys 
    50                  55                  60                  


Gly Arg Ile Val Phe Arg Ser Arg 
65                  70          


<210>  16
<211>  213
<212>  DNA
<213>  Synthetic


<220>
<221>  misc_feature
<223>  Modified E.coli infA

<400>  16
gccaaagaag acaatattga aatgcaaggt accgttcttg aaacgttgcc taataccatg       60

ttccgcgtag agttagaaaa cggtcacgtg gttactgcac acatctccgg taaaatgcgc      120

aaaaactaca tccgcatcct gacgggcgac aaagtgactg ttgaactgac cccgtacgac      180

ctgagcaaag gccgcattgt cttcctgagt cgc                                   213


<210>  17
<211>  71
<212>  PRT
<213>  Synthetic


<220>
<221>  MISC_FEATURE
<223>  Modified IF1 protein without initial Met

<400>  17

Ala Lys Glu Asp Asn Ile Glu Met Gln Gly Thr Val Leu Glu Thr Leu 
1               5                   10                  15      


Pro Asn Thr Met Phe Arg Val Glu Leu Glu Asn Gly His Val Val Thr 
            20                  25                  30          


Ala His Ile Ser Gly Lys Met Arg Lys Asn Tyr Ile Arg Ile Leu Thr 
        35                  40                  45              


Gly Asp Lys Val Thr Val Glu Leu Thr Pro Tyr Asp Leu Ser Lys Gly 
    50                  55                  60                  


Arg Ile Val Phe Leu Ser Arg 
65                  70      


<210>  18
<211>  127
<212>  DNA
<213>  Listeria monocytogenes


<220>
<221>  misc_feature
<223>  wt L.monocytogenes prfA

<400>  18
tgtaaaaaac atcatttagc gtgactttct ttcaacagct aacaattgtt gttactgcct       60

aatgttttta gggtatttta aaaaagggcg ataaaaaacg attgggggat gagaaatgaa      120

cgctcaa                                                                127


<210>  19
<211>  4
<212>  PRT
<213>  Listeria monocytogenes


<220>
<221>  MISC_FEATURE
<223>  wt L.monocytogenes prfA

<400>  19

Met Asn Ala Gln 
1               


<210>  20
<211>  10
<212>  DNA
<213>  synthetic


<220>
<221>  misc_feature
<223>  Kozak

<400>  20
gccrccatgg                                                              10


<210>  21
<211>  22
<212>  PRT
<213>  synthetic


<220>
<221>  MISC_FEATURE
<223>  FMDV 2A tag

<400>  21

Val Lys Gln Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val 
1               5                   10                  15      


Glu Ser Asn Pro Gly Pro 
            20          


<210>  22
<211>  20
<212>  PRT
<213>  Thosea asigna


<220>
<221>  MISC_FEATURE
<223>  TaV 2A

<400>  22

Arg Ala Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu 
1               5                   10                  15      


Asn Pro Gly Pro 
            20  


<210>  23
<211>  19
<212>  PRT
<213>  Synthetic


<220>
<221>  MISC_FEATURE
<223>  P2A

<400>  23

Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn 
1               5                   10                  15      


Pro Gly Pro 
            


<210>  24
<211>  224
<212>  DNA
<213>  synthetic


<220>
<221>  misc_feature
<223>  bGH_PA terminator

<400>  24
gccttcagtt gccagccatc tgttgtttgc ccctcccccg tgccttcctt gaccctggaa       60

ggtgccactc ccactgtcct ttcctaataa aatgaggaaa ttgcatcgca ttgtctgagt      120

aggtgtcatt ctattctggg gggtggggtg gggcaggaca gcaaggggga ggattgggaa      180

gacaatagca ggcatgctgg ggatgcggtg ggctctatgg cttc                       224


<210>  25
<211>  225
<212>  DNA
<213>  synthetic


<220>
<221>  misc_feature
<223>  bGH_PA terminator

<400>  25
gccttctagt tgccagccat ctgttgtttg cccctccccc gtgccttcct tgaccctgga       60

aggtgccact cccactgtcc tttcctaata aaatgaggaa attgcatcgc attgtctgag      120

taggtgtcat tctattctgg ggggtggggt ggggcaggac agcaaggggg aggattggga      180

agacaatagc aggcatgctg gggatgcggt gggctctatg gcttc                      225


<210>  26
<211>  390
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  Human endogenous TGF-beta1

<400>  26

Met Pro Pro Ser Gly Leu Arg Leu Leu Leu Leu Leu Leu Pro Leu Leu 
1               5                   10                  15      


Trp Leu Leu Val Leu Thr Pro Gly Arg Pro Ala Ala Gly Leu Ser Thr 
            20                  25                  30          


Cys Lys Thr Ile Asp Met Glu Leu Val Lys Arg Lys Arg Ile Glu Ala 
        35                  40                  45              


Ile Arg Gly Gln Ile Leu Ser Lys Leu Arg Leu Ala Ser Pro Pro Ser 
    50                  55                  60                  


Gln Gly Glu Val Pro Pro Gly Pro Leu Pro Glu Ala Val Leu Ala Leu 
65                  70                  75                  80  


Tyr Asn Ser Thr Arg Asp Arg Val Ala Gly Glu Ser Ala Glu Pro Glu 
                85                  90                  95      


Pro Glu Pro Glu Ala Asp Tyr Tyr Ala Lys Glu Val Thr Arg Val Leu 
            100                 105                 110         


Met Val Glu Thr His Asn Glu Ile Tyr Asp Lys Phe Lys Gln Ser Thr 
        115                 120                 125             


His Ser Ile Tyr Met Phe Phe Asn Thr Ser Glu Leu Arg Glu Ala Val 
    130                 135                 140                 


Pro Glu Pro Val Leu Leu Ser Arg Ala Glu Leu Arg Leu Leu Arg Leu 
145                 150                 155                 160 


Lys Leu Lys Val Glu Gln His Val Glu Leu Tyr Gln Lys Tyr Ser Asn 
                165                 170                 175     


Asn Ser Trp Arg Tyr Leu Ser Asn Arg Leu Leu Ala Pro Ser Asp Ser 
            180                 185                 190         


Pro Glu Trp Leu Ser Phe Asp Val Thr Gly Val Val Arg Gln Trp Leu 
        195                 200                 205             


Ser Arg Gly Gly Glu Ile Glu Gly Phe Arg Leu Ser Ala His Cys Ser 
    210                 215                 220                 


Cys Asp Ser Arg Asp Asn Thr Leu Gln Val Asp Ile Asn Gly Phe Thr 
225                 230                 235                 240 


Thr Gly Arg Arg Gly Asp Leu Ala Thr Ile His Gly Met Asn Arg Pro 
                245                 250                 255     


Phe Leu Leu Leu Met Ala Thr Pro Leu Glu Arg Ala Gln His Leu Gln 
            260                 265                 270         


Ser Ser Arg His Arg Arg Ala Leu Asp Thr Asn Tyr Cys Phe Ser Ser 
        275                 280                 285             


Thr Glu Lys Asn Cys Cys Val Arg Gln Leu Tyr Ile Asp Phe Arg Lys 
    290                 295                 300                 


Asp Leu Gly Trp Lys Trp Ile His Glu Pro Lys Gly Tyr His Ala Asn 
305                 310                 315                 320 


Phe Cys Leu Gly Pro Cys Pro Tyr Ile Trp Ser Leu Asp Thr Gln Tyr 
                325                 330                 335     


Ser Lys Val Leu Ala Leu Tyr Asn Gln His Asn Pro Gly Ala Ser Ala 
            340                 345                 350         


Ala Pro Cys Cys Val Pro Gln Ala Leu Glu Pro Leu Pro Ile Val Tyr 
        355                 360                 365             


Tyr Val Gly Arg Lys Pro Lys Val Glu Gln Leu Ser Asn Met Ile Val 
    370                 375                 380                 


Arg Ser Cys Lys Cys Ser 
385                 390 


<210>  27
<211>  390
<212>  PRT
<213>  synthetic


<220>
<221>  MISC_FEATURE
<223>  Modified TGF-beta1

<400>  27

Met Pro Pro Ser Gly Leu Arg Leu Leu Leu Leu Leu Leu Pro Leu Leu 
1               5                   10                  15      


Trp Leu Leu Val Leu Thr Pro Gly Arg Pro Ala Ala Gly Leu Ser Thr 
            20                  25                  30          


Cys Lys Thr Ile Asp Met Glu Leu Val Lys Arg Lys Arg Ile Glu Ala 
        35                  40                  45              


Ile Arg Gly Gln Ile Leu Ser Lys Leu Arg Leu Ala Ser Pro Pro Ser 
    50                  55                  60                  


Gln Gly Glu Val Pro Pro Gly Pro Leu Pro Glu Ala Val Leu Ala Leu 
65                  70                  75                  80  


Tyr Asn Ser Thr Arg Asp Arg Val Ala Gly Glu Ser Ala Glu Pro Glu 
                85                  90                  95      


Pro Glu Pro Glu Ala Asp Tyr Tyr Ala Lys Glu Val Thr Arg Val Leu 
            100                 105                 110         


Met Val Glu Thr His Asn Glu Ile Tyr Asp Lys Phe Lys Gln Ser Thr 
        115                 120                 125             


His Ser Ile Tyr Met Phe Phe Asn Thr Ser Glu Leu Arg Glu Ala Val 
    130                 135                 140                 


Pro Glu Pro Val Leu Leu Ser Arg Ala Glu Leu Arg Leu Leu Arg Leu 
145                 150                 155                 160 


Lys Leu Lys Val Glu Gln His Val Glu Leu Tyr Gln Lys Tyr Ser Asn 
                165                 170                 175     


Asn Ser Trp Arg Tyr Leu Ser Asn Arg Leu Leu Ala Pro Ser Asp Ser 
            180                 185                 190         


Pro Glu Trp Leu Ser Phe Asp Val Thr Gly Val Val Arg Gln Trp Leu 
        195                 200                 205             


Ser Arg Gly Gly Glu Ile Glu Gly Phe Arg Leu Ser Ala His Val Ser 
    210                 215                 220                 


Val Asp Ser Arg Asp Asn Thr Leu Gln Val Asp Ile Asn Gly Phe Thr 
225                 230                 235                 240 


Thr Gly Arg Arg Gly Asp Leu Ala Thr Ile His Gly Met Asn Arg Pro 
                245                 250                 255     


Phe Leu Leu Leu Met Ala Thr Pro Leu Glu Arg Ala Gln His Leu Gln 
            260                 265                 270         


Ser Ser Arg His Arg Arg Ala Leu Asp Thr Asn Tyr Cys Phe Ser Ser 
        275                 280                 285             


Thr Glu Lys Asn Cys Cys Val Arg Gln Leu Tyr Ile Asp Phe Arg Lys 
    290                 295                 300                 


Asp Leu Gly Trp Lys Trp Ile His Glu Pro Lys Gly Tyr His Ala Asn 
305                 310                 315                 320 


Phe Cys Leu Gly Pro Cys Pro Tyr Ile Trp Ser Leu Asp Thr Gln Tyr 
                325                 330                 335     


Ser Lys Val Leu Ala Leu Tyr Asn Gln His Asn Pro Gly Ala Ser Ala 
            340                 345                 350         


Ala Pro Cys Cys Val Pro Gln Ala Leu Glu Pro Leu Pro Ile Val Tyr 
        355                 360                 365             


Tyr Val Gly Arg Lys Pro Lys Val Glu Gln Leu Ser Asn Met Ile Val 
    370                 375                 380                 


Arg Ser Cys Lys Cys Ser 
385                 390 


<210>  28
<211>  390
<212>  PRT
<213>  synthetic


<220>
<221>  MISC_FEATURE
<223>  Modified TGF-beta1

<400>  28

Met Pro Pro Ser Gly Leu Arg Leu Leu Leu Leu Leu Leu Pro Leu Leu 
1               5                   10                  15      


Trp Leu Leu Val Leu Thr Pro Gly Arg Pro Ala Ala Gly Leu Ser Thr 
            20                  25                  30          


Cys Lys Thr Ile Asp Met Glu Leu Val Lys Arg Lys Arg Ile Glu Ala 
        35                  40                  45              


Ile Arg Gly Gln Ile Leu Ser Lys Leu Arg Leu Ala Ser Pro Pro Ser 
    50                  55                  60                  


Gln Gly Glu Val Pro Pro Gly Pro Leu Pro Glu Ala Val Leu Ala Leu 
65                  70                  75                  80  


Tyr Asn Ser Thr Arg Asp Arg Val Ala Gly Glu Ser Ala Glu Pro Glu 
                85                  90                  95      


Pro Glu Pro Glu Ala Asp Tyr Tyr Ala Lys Glu Val Thr Arg Val Leu 
            100                 105                 110         


Met Val Glu Thr His Asn Glu Ile Tyr Asp Lys Phe Lys Gln Ser Thr 
        115                 120                 125             


His Ser Ile Tyr Met Phe Phe Asn Thr Ser Glu Leu Arg Glu Ala Val 
    130                 135                 140                 


Pro Glu Pro Val Leu Leu Ser Arg Ala Glu Leu Arg Leu Leu Arg Leu 
145                 150                 155                 160 


Lys Leu Lys Val Glu Gln His Val Glu Leu Tyr Gln Lys Tyr Ser Asn 
                165                 170                 175     


Asn Ser Trp Arg Tyr Leu Ser Asn Arg Leu Leu Ala Pro Ser Asp Ser 
            180                 185                 190         


Pro Glu Trp Leu Ser Phe Asp Val Thr Gly Val Val Arg Gln Trp Leu 
        195                 200                 205             


Ser Arg Gly Gly Glu Ile Glu Gly Phe Arg Leu Ser Ala His Ser Ser 
    210                 215                 220                 


Ser Asp Ser Arg Asp Asn Thr Leu Gln Val Asp Ile Asn Gly Phe Thr 
225                 230                 235                 240 


Thr Gly Arg Arg Gly Asp Leu Ala Thr Ile His Gly Met Asn Arg Pro 
                245                 250                 255     


Phe Leu Leu Leu Met Ala Thr Pro Leu Glu Arg Ala Gln His Leu Gln 
            260                 265                 270         


Ser Ser Arg His Arg Arg Ala Leu Asp Thr Asn Tyr Cys Phe Ser Ser 
        275                 280                 285             


Thr Glu Lys Asn Cys Cys Val Arg Gln Leu Tyr Ile Asp Phe Arg Lys 
    290                 295                 300                 


Asp Leu Gly Trp Lys Trp Ile His Glu Pro Lys Gly Tyr His Ala Asn 
305                 310                 315                 320 


Phe Cys Leu Gly Pro Cys Pro Tyr Ile Trp Ser Leu Asp Thr Gln Tyr 
                325                 330                 335     


Ser Lys Val Leu Ala Leu Tyr Asn Gln His Asn Pro Gly Ala Ser Ala 
            340                 345                 350         


Ala Pro Cys Cys Val Pro Gln Ala Leu Glu Pro Leu Pro Ile Val Tyr 
        355                 360                 365             


Tyr Val Gly Arg Lys Pro Lys Val Glu Gln Leu Ser Asn Met Ile Val 
    370                 375                 380                 


Arg Ser Cys Lys Cys Ser 
385                 390 


<210>  29
<211>  390
<212>  PRT
<213>  synthetic


<220>
<221>  MISC_FEATURE
<223>  Modified TGF-beta1

<400>  29

Met Pro Pro Ser Gly Leu Arg Leu Leu Pro Leu Leu Leu Pro Leu Pro 
1               5                   10                  15      


Trp Leu Leu Val Leu Thr Pro Gly Arg Pro Ala Ala Gly Leu Ser Thr 
            20                  25                  30          


Cys Lys Thr Ile Asp Met Glu Leu Val Lys Arg Lys Arg Ile Glu Ala 
        35                  40                  45              


Ile Arg Gly Gln Ile Leu Ser Lys Leu Arg Leu Ala Ser Pro Pro Ser 
    50                  55                  60                  


Gln Gly Glu Val Pro Pro Gly Pro Leu Pro Glu Ala Val Leu Ala Leu 
65                  70                  75                  80  


Tyr Asn Ser Thr Arg Asp Arg Val Ala Gly Glu Ser Ala Asp Pro Glu 
                85                  90                  95      


Pro Glu Pro Glu Ala Asp Tyr Tyr Ala Lys Glu Val Thr Arg Val Leu 
            100                 105                 110         


Met Val Asp Arg Asn Asn Ala Ile Tyr Glu Lys Thr Lys Asp Ile Ser 
        115                 120                 125             


His Ser Ile Tyr Met Phe Phe Asn Thr Ser Asp Ile Arg Glu Ala Val 
    130                 135                 140                 


Pro Glu Pro Pro Leu Leu Ser Arg Ala Glu Leu Arg Leu Gln Arg Leu 
145                 150                 155                 160 


Lys Ser Ser Val Glu Gln His Val Glu Leu Tyr Gln Lys Tyr Ser Asn 
                165                 170                 175     


Asn Ser Trp Arg Tyr Leu Gly Asn Arg Leu Leu Thr Pro Thr Asp Thr 
            180                 185                 190         


Pro Glu Trp Leu Ser Phe Asp Val Thr Gly Val Val Arg Gln Trp Leu 
        195                 200                 205             


Asn Gln Gly Asp Gly Ile Gln Gly Phe Arg Phe Ser Ala His Ser Ser 
    210                 215                 220                 


Ser Asp Ser Lys Asp Asn Lys Leu His Val Glu Ile Asn Gly Ile Ser 
225                 230                 235                 240 


Pro Lys Arg Arg Gly Asp Leu Gly Thr Ile His Asp Met Asn Arg Pro 
                245                 250                 255     


Phe Leu Leu Leu Met Ala Thr Pro Leu Glu Arg Ala Gln His Leu His 
            260                 265                 270         


Ser Ser Arg His Arg Arg Ala Leu Asp Thr Asn Tyr Cys Phe Ser Ser 
        275                 280                 285             


Thr Glu Lys Asn Cys Cys Val Arg Gln Leu Tyr Ile Asp Phe Arg Lys 
    290                 295                 300                 


Asp Leu Gly Trp Lys Trp Ile His Glu Pro Lys Gly Tyr His Ala Asn 
305                 310                 315                 320 


Phe Cys Leu Gly Pro Cys Pro Tyr Ile Trp Ser Leu Asp Thr Gln Tyr 
                325                 330                 335     


Ser Lys Val Leu Ala Leu Tyr Asn Gln His Asn Pro Gly Ala Ser Ala 
            340                 345                 350         


Ser Pro Cys Cys Val Pro Gln Ala Leu Glu Pro Leu Pro Ile Val Tyr 
        355                 360                 365             


Tyr Val Gly Arg Lys Pro Lys Val Glu Gln Leu Ser Asn Met Ile Val 
    370                 375                 380                 


Arg Ser Cys Lys Cys Ser 
385                 390 


<210>  30
<211>  630
<212>  DNA
<213>  synthetic


<220>
<221>  misc_feature
<223>  EMCV IRES element

<400>  30
taaacgcgtc gagcatgcat ctagggcggc caattccgcc cctctccccc ccacccctct       60

ccctcccccc cccctaacgt tactggccga agccgcttgg aataaggccg gtgtgcgttt      120

gtctatatgt tattttccac catattgccg tcttttggca atgtgagggc ccggaaacct      180

ggccctgtct tcttgacgag cattcctagg ggtctttccc ctctcgccaa aggaatgcaa      240

ggtctgttga atgtcgtgaa ggaagcagtt cctctggaag cttcttgaag acaaacaacg      300

tctgtagcga ccctttgtag acagcggaac cccccacctg gcgatagatg cctctgcggc      360

caaaagccac gtgtataaga tacacctgca aaggcggcac aaccccagtg ccacgttgtg      420

agttggatag ttgtggaaag agtcaaatgg ctctcctcaa gcgtattcaa caaggggctg      480

aaggatgccc agaaggtacc ccattgtatg ggatctgatc tggggcctcg gtgcacatgc      540

tttacatgtg tttagtcgag gttaaaaaac gtctaggccc cccgaaccac ggggacgtgg      600

ttttcctttg aaaaacacga tgataatatg                                       630


<210>  31
<211>  784
<212>  DNA
<213>  synthetic


<220>
<221>  misc_feature
<223>  pUC Ori

<400>  31
taaaacttca tttttaattt aaaaggatct aggtgaagat cctttttgat aatctcatga       60

ccaaaatccc ttaacgtgag ttttcgttcc actgagcgtc agaccccgta gaaaagatca      120

aaggatcttc ttgagatcct ttttttctgc gcgtaatctg ctgcttgcaa acaaaaaaac      180

caccgctacc agcggtggtt tgtttgccgg atcaagagct accaactctt tttccgaagg      240

taactggctt cagcagagcg cagataccaa atactgttct tctagtgtag ccgtagttag      300

gccaccactt caagaactct gtagcaccgc ctacatacct cgctctgcta atcctgttac      360

cagtggctgc tgccagtggc gataagtcgt gtcttaccgg gttggactca agacgatagt      420

taccggataa ggcgcagcgg tcgggctgaa cggggggttc gtgcacacag cccagcttgg      480

agcgaacgac ctacaccgaa ctgagatacc tacagcgtga gctatgagaa agcgccacgc      540

ttcccgaagg gagaaaggcg gacaggtatc cggtaagcgg cagggtcgga acaggagagc      600

gcacgaggga gcttccaggg ggaaacgcct ggtatcttta tagtcctgtc gggtttcgcc      660

acctctgact tgagcgtcga tttttgtgat gctcgtcagg ggggcggagc ctatggaaaa      720

acgccagcaa cgcggccttt ttacggttcc tgggcttttg ctggcctttt gctcacatgt      780

tctt                                                                   784


<210>  32
<211>  487
<212>  DNA
<213>  synthetic


<220>
<221>  misc_feature
<223>  CMV promoter and enhancer

<400>  32
ttgacattga ttattgacta gttattaata gtaatcaatt acggggtcat tagttcatag       60

cccatatatg gagttccgcg ttacataact tacggtaaat ggcccgcctg gctgaccgcc      120

caacgacccc cgcccattga cgtcaataat gacgtatgtt cccatagtaa cgccaatagg      180

gactttccat tgacgtcaat gggtggacta tttacggtaa actgcccact tggcagtaca      240

tcaagtgtat catatgccaa gtacgccccc tattgacgtc aatgacggta aatggcccgc      300

ctggcattat gcccagtaca tgaccttatg ggactttcct acttggcagt acatctacgt      360

attagtcatc gctattacca tggtgatgcg gttttggcag tacatcaatg ggcgtggata      420

gcggtttgac tcacggggat ttccaagtct ccaccccatt gacgtcaatg ggagtttgtt      480

ttggcac                                                                487


<210>  33
<211>  107
<212>  DNA
<213>  synthetic


<220>
<221>  misc_feature
<223>  beta-globin intron

<400>  33
gttaacttaa tgagacagat agaaactggt cttgtagaaa cagagtagtc gcctgctttt       60

ctgccaggtg ctgacttctc tcccctgggc ttttttcttt ttctcag                    107


<210>  34
<211>  106
<212>  DNA
<213>  synthetic


<220>
<221>  misc_feature
<223>  Beta-globin intron

<400>  34
gtaagttaat gagacagata gaaactggtc ttgtagaaac agagtagtcg cctgcttttc       60

tgccaggtgc tgacttctct cccctgggct tttttctttt tctcag                     106


<210>  35
<211>  226
<212>  DNA
<213>  synthetic


<220>
<221>  misc_feature
<223>  HTLV-IR

<400>  35
ctcgcatctc tccttcacgc gcccgccgcc ctacctgagg ccgccatcca cgccggttga       60

gtcgcgttct gccgcctccc gcctgtggtg cctcctgaac tgcgtccgcc gtctaggtaa      120

gtttaaagct caggtcgaga ccgggccttt gtccggcgct cccttggagc ctacctagac      180

tcagccggct ctccacgctt tgcctgaccc tgcttgctca actcta                     226


<210>  36
<211>  26
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<223>  mli-pre (CD74)

<400>  36

Met Asp Asp Gln Arg Asp Leu Ile Ser Asn His Glu Gln Leu Pro Ile 
1               5                   10                  15      


Leu Gly Asn Arg Pro Arg Glu Pro Glu Arg 
            20                  25      


<210>  37
<211>  55
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<223>  mli-post (CD74)

<400>  37

Cys Ser Arg Gly Ala Leu Tyr Thr Gly Val Ser Val Leu Val Ala Leu 
1               5                   10                  15      


Leu Leu Ala Gly Gln Ala Thr Thr Ala Tyr Phe Leu Tyr Gln Gln Gln 
            20                  25                  30          


Gly Arg Leu Asp Lys Leu Thr Ile Thr Ser Gln Asn Leu Gln Leu Glu 
        35                  40                  45              


Ser Leu Arg Met Lys Leu Pro 
    50                  55  


<210>  38
<211>  81
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<223>  mli-pre and mli-post

<400>  38

Met Asp Asp Gln Arg Asp Leu Ile Ser Asn His Glu Gln Leu Pro Ile 
1               5                   10                  15      


Leu Gly Asn Arg Pro Arg Glu Pro Glu Arg Cys Ser Arg Gly Ala Leu 
            20                  25                  30          


Tyr Thr Gly Val Ser Val Leu Val Ala Leu Leu Leu Ala Gly Gln Ala 
        35                  40                  45              


Thr Thr Ala Tyr Phe Leu Tyr Gln Gln Gln Gly Arg Leu Asp Lys Leu 
    50                  55                  60                  


Thr Ile Thr Ser Gln Asn Leu Gln Leu Glu Ser Leu Arg Met Lys Leu 
65                  70                  75                  80  


Pro 
    


<210>  39
<211>  42
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  CD74 pre

<400>  39

Met Ala His Arg Arg Arg Ser Arg Ser Cys Arg Glu Asp Gln Lys Pro 
1               5                   10                  15      


Val Met Asp Asp Gln Arg Asp Leu Ile Ser Asn Asn Glu Gln Leu Pro 
            20                  25                  30          


Met Leu Gly Arg Arg Pro Gly Ala Pro Glu 
        35                  40          


<210>  40
<211>  56
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  CD74 post

<400>  40

Gln Val Gln Gln Arg Ser Leu Val His Gly Val Leu His Phe Ser Asp 
1               5                   10                  15      


Ser Pro Ser Arg Arg Pro Ser Tyr His Arg Leu Leu Ser Val Pro Thr 
            20                  25                  30          


Ala Arg Gln Thr Arg Gln Thr Asp Asn His Lys Pro Glu Pro Ser Ala 
        35                  40                  45              


Gly Val Ser Ala Asp Glu Ala Ala 
    50                  55      


<210>  41
<211>  98
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  CD74 pre+CD74 post

<400>  41

Met Ala His Arg Arg Arg Ser Arg Ser Cys Arg Glu Asp Gln Lys Pro 
1               5                   10                  15      


Val Met Asp Asp Gln Arg Asp Leu Ile Ser Asn Asn Glu Gln Leu Pro 
            20                  25                  30          


Met Leu Gly Arg Arg Pro Gly Ala Pro Glu Gln Val Gln Gln Arg Ser 
        35                  40                  45              


Leu Val His Gly Val Leu His Phe Ser Asp Ser Pro Ser Arg Arg Pro 
    50                  55                  60                  


Ser Tyr His Arg Leu Leu Ser Val Pro Thr Ala Arg Gln Thr Arg Gln 
65                  70                  75                  80  


Thr Asp Asn His Lys Pro Glu Pro Ser Ala Gly Val Ser Ala Asp Glu 
                85                  90                  95      


Ala Ala 
        


