                         SEQUENCE LISTING

<110>  AL-S Pharma AG
       Neurimmune AG
 
<120>  Misfolded SOD1 Assay

<130>  AL57A02/P-WO

<150>  EP 20 163 909.3
<151>  2020-03-18

<160>  22    

<170>  PatentIn version 3.5

<210>  1
<211>  123
<212>  PRT
<213>  Homo sapiens

<400>  1

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Thr Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ala Tyr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Arg Glu Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Val Ile Asn Pro Ser Thr Gly Thr Thr Phe Tyr Ala Gln Asn Phe 
    50                  55                  60                  


Pro Asp Arg Val Ser Val Thr Arg Asp Thr Ser Thr Ser Thr Val Phe 
65                  70                  75                  80  


Met Glu Leu His Asn Leu Lys Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Ile Ser Glu His Gly Ser Gly Ser Tyr Ser Pro Tyr Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  2
<211>  123
<212>  PRT
<213>  Homo sapiens

<400>  2

Glu Val Gln Leu Val Glu Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Thr Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ala Tyr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Arg Glu Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Val Ile Asn Pro Ser Thr Gly Thr Thr Phe Tyr Ala Gln Asn Phe 
    50                  55                  60                  


Pro Asp Arg Val Ser Val Thr Arg Asp Thr Ser Thr Ser Thr Val Phe 
65                  70                  75                  80  


Met Glu Leu His Asn Leu Lys Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Ile Ser Glu His Gly Ser Gly Ser Tyr Ser Pro Tyr Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  3
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  3

Ala Tyr Tyr Ile His 
1               5   


<210>  4
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  4

Val Ile Asn Pro Ser Thr Gly Thr Thr Phe Tyr Ala Gln Asn Phe Pro 
1               5                   10                  15      


Asp 
    


<210>  5
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  5

Ala Ile Ser Glu His Gly Ser Gly Ser Tyr Ser Pro Tyr Tyr 
1               5                   10                  


<210>  6
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  6

Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Leu Gly Gln 
1               5                   10                  15      


Met Ala Ala Ile Thr Cys Ser Gly Glu Ala Leu Pro Lys Lys Tyr Gly 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Val Pro Val Leu Leu Ile Tyr 
        35                  40                  45              


Arg Asp Val Glu Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  


Ser Ser Gly Thr Met Val Thr Leu Thr Ile Ser Gly Val Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Leu Ser Ala Asp Ser Ser Gly Thr Trp 
                85                  90                  95      


Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105         


<210>  7
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  7

Ser Tyr Val Leu Thr Gln Pro Pro Ser Val Ser Val Ser Leu Gly Gln 
1               5                   10                  15      


Met Ala Ala Ile Thr Cys Ser Gly Glu Ala Leu Pro Lys Lys Tyr Gly 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Val Pro Val Leu Leu Ile Tyr 
        35                  40                  45              


Arg Asp Val Glu Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  


Ser Ser Gly Thr Met Val Thr Leu Thr Ile Ser Gly Val Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Leu Ser Ala Asp Ser Ser Gly Thr Trp 
                85                  90                  95      


Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105         


<210>  8
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  8

Ser Gly Glu Ala Leu Pro Lys Lys Tyr Gly Tyr 
1               5                   10      


<210>  9
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  9

Arg Asp Val Glu Arg Pro Ser 
1               5           


<210>  10
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  10

Leu Ser Ala Asp Ser Ser Gly Thr Trp Val 
1               5                   10  


<210>  11
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide comprising epitope of NI-204.B and NI-204.O

<400>  11

Gly Gly Pro Lys Asp Glu Glu Arg His Val Gly Asp 
1               5                   10          


<210>  12
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide comprising the epitope of NI-204.B

<400>  12

Gly Gly Pro Lys Asp Glu Glu Arg His Val Gly 
1               5                   10      


<210>  13
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide comprising the epitope of NI-204.O

<400>  13

Lys Asp Glu Glu Arg His Val Gly Asp 
1               5                   


<210>  14
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide comprising the epitope of NI-204.G

<400>  14

His Glu Lys Ala Asp Asp Leu Gly Lys Gly Gly Asn Glu Glu Ser 
1               5                   10                  15  


<210>  15
<211>  121
<212>  PRT
<213>  Homo sapiens

<400>  15

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Ile Phe Ser Ser Phe 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Thr Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Leu Ile Trp Tyr Asp Gly Ser Arg Gln Ser Tyr Ala Asp Ser Val 
    50                  55                  60                  


Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Gly Glu Asp Thr Ala Val Tyr His Cys 
                85                  90                  95      


Ala Arg Thr Gly Tyr Asp Asp Lys Arg Gly Gly Phe Asp Thr Trp Gly 
            100                 105                 110         


Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120     


<210>  16
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  16

Ser Phe Gly Met His 
1               5   


<210>  17
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  17

Leu Ile Trp Tyr Asp Gly Ser Arg Gln Ser Tyr Ala Asp Ser Val Arg 
1               5                   10                  15      


Gly 
    


<210>  18
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  18

Thr Gly Tyr Asp Asp Lys Arg Gly Gly Phe Asp Thr 
1               5                   10          


<210>  19
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  19

Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Ser Gly Asp Ala Leu Ala Lys Gln Tyr Ser 
            20                  25                  30          


Tyr Trp Tyr Gln His Lys Pro Gly Gln Ala Pro Val Met Val Met Tyr 
        35                  40                  45              


Lys Asp Arg Glu Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Ser Ser Gly Thr Thr Val Thr Leu Thr Ile Ser Ala Val Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Thr Gly Thr Asp Ser Pro Tyr 
                85                  90                  95      


Ile Phe Gly Thr Gly Thr Lys Val Thr Val Leu 
            100                 105         


<210>  20
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  20

Ser Gly Asp Ala Leu Ala Lys Gln Tyr Ser Tyr 
1               5                   10      


<210>  21
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  21

Lys Asp Arg Glu Arg Pro Ser 
1               5           


<210>  22
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  22

Gln Ser Thr Gly Thr Asp Ser Pro Tyr Ile 
1               5                   10  


