                         SEQUENCE LISTING

<110>  GEMoaB GmbH
 
<120>  A targeting module comprising PD-L1 and/or PD-L2 for use in a 
       method for stimulating a chimeric antigen receptor mediated 
       immune response in a mammal

<130>  01281P0022EPWO

<150>  EP 20 163 257.7
<151>  2020-03-16

<160>  108   

<170>  PatentIn version 3.5

<210>  1
<211>  272
<212>  PRT
<213>  Homo sapiens

<400>  1

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr His Leu Val 
    210                 215                 220                 


Ile Leu Gly Ala Ile Leu Leu Cys Leu Gly Val Ala Leu Thr Phe Ile 
225                 230                 235                 240 


Phe Arg Leu Arg Lys Gly Arg Met Met Asp Val Lys Lys Cys Gly Ile 
                245                 250                 255     


Gln Asp Thr Asn Ser Lys Lys Gln Ser Asp Thr His Leu Glu Glu Thr 
            260                 265                 270         


<210>  2
<211>  254
<212>  PRT
<213>  Homo sapiens

<400>  2

Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu His Gly 
1               5                   10                  15      


Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn 
            20                  25                  30          


Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser 
        35                  40                  45              


Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly 
    50                  55                  60                  


Lys Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln 
65                  70                  75                  80  


Tyr Gln Cys Ile Ile Ile Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu 
                85                  90                  95      


Thr Leu Lys Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr His Ile Leu 
            100                 105                 110         


Lys Val Pro Glu Thr Asp Glu Val Glu Leu Thr Cys Gln Ala Thr Gly 
        115                 120                 125             


Tyr Pro Leu Ala Glu Val Ser Trp Pro Asn Val Ser Val Pro Ala Asn 
    130                 135                 140                 


Thr Ser His Ser Arg Thr Pro Glu Gly Leu Tyr Gln Val Thr Ser Val 
145                 150                 155                 160 


Leu Arg Leu Lys Pro Pro Pro Gly Arg Asn Phe Ser Cys Val Phe Trp 
                165                 170                 175     


Asn Thr His Val Arg Glu Leu Thr Leu Ala Ser Ile Asp Leu Gln Ser 
            180                 185                 190         


Gln Met Glu Pro Arg Thr His Pro Thr Trp Leu Leu His Ile Phe Ile 
        195                 200                 205             


Pro Phe Cys Ile Ile Ala Phe Ile Phe Ile Ala Thr Val Ile Ala Leu 
    210                 215                 220                 


Arg Lys Gln Leu Cys Gln Lys Leu Tyr Ser Ser Lys Asp Thr Thr Lys 
225                 230                 235                 240 


Arg Pro Val Thr Thr Thr Lys Arg Glu Val Asn Ser Ala Ile 
                245                 250                 


<210>  3
<211>  265
<212>  PRT
<213>  Homo sapiens

<400>  3

Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro 
1               5                   10                  15      


Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser 
            20                  25                  30          


Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser 
        35                  40                  45              


Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser 
    50                  55                  60                  


Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly 
65                  70                  75                  80  


Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly 
                85                  90                  95      


Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Ala Gln Ile Lys 
            100                 105                 110         


Glu Ser Leu Arg Ala Glu Leu Arg Val Thr Glu Arg Arg Ala Glu Val 
        115                 120                 125             


Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly Gln Phe Gln 
    130                 135                 140                 


Thr Leu Val Val Gly Val Val Gly Gly Leu Leu Gly Ser Leu Val Leu 
145                 150                 155                 160 


Leu Val Trp Val Leu Ala Val Ile Cys Ser Arg Ala Ala Arg Gly Thr 
                165                 170                 175     


Ile Gly Ala Arg Arg Thr Gly Gln Pro Leu Lys Glu Asp Pro Ser Ala 
            180                 185                 190         


Val Pro Val Phe Ser Val Asp Tyr Gly Glu Leu Asp Phe Gln Trp Arg 
        195                 200                 205             


Glu Lys Thr Pro Glu Pro Pro Val Pro Cys Val Pro Glu Gln Thr Glu 
    210                 215                 220                 


Tyr Ala Thr Ile Val Phe Pro Ser Gly Met Gly Thr Ser Ser Pro Ala 
225                 230                 235                 240 


Arg Arg Gly Ser Ala Asp Gly Pro Arg Ser Ala Gln Pro Leu Arg Pro 
                245                 250                 255     


Glu Asp Gly His Cys Ser Trp Pro Leu 
            260                 265 


<210>  4
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized VH chain

<400>  4

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Thr Ser Gly Asp Thr Phe Ser Thr Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Lys Ala His Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Lys Phe His Phe Val Ser Gly Ser Pro Phe Gly Met Asp Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  5
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized VL chain

<400>  5

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210>  6
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized VH chain

<400>  6

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Ser 
            20                  25                  30          


Trp Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Trp Ile Ser Pro Tyr Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg His Trp Pro Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  7
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized VL chain

<400>  7

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Ser Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Leu Tyr His Pro Ala 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  8
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized VH chain

<400>  8

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Tyr 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asn Ile Lys Gln Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gly Gly Trp Phe Gly Glu Leu Ala Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  9
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized VL chain

<400>  9

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Arg Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Asp Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Leu Pro 
                85                  90                  95      


Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  10
<211>  33
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  10

Arg Met Lys Gln Leu Glu Pro Lys Val Glu Glu Leu Leu Pro Lys Asn 
1               5                   10                  15      


Tyr His Leu Glu Asn Glu Val Ala Arg Leu Lys Lys Leu Val Gly Glu 
            20                  25                  30          


Arg 
    


<210>  11
<211>  14
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  11

Asn Tyr His Leu Glu Asn Glu Val Ala Arg Leu Lys Lys Leu 
1               5                   10                  


<210>  12
<211>  51
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Asp Pro Asp Leu Glu Ile Arg Ala Ala Phe Leu Arg Gln Arg Asn 
1               5                   10                  15      


Thr Ala Leu Arg Thr Glu Val Ala Glu Leu Glu Gln Glu Val Gln Arg 
            20                  25                  30          


Leu Glu Asn Glu Val Ser Gln Tyr Glu Thr Arg Tyr Gly Pro Leu Gly 
        35                  40                  45              


Gly Gly Lys 
    50      


<210>  13
<211>  51
<212>  PRT
<213>  Homo sapiens

<400>  13

Met Asp Pro Asp Leu Glu Ile Glu Ala Ala Phe Leu Glu Arg Glu Asn 
1               5                   10                  15      


Thr Ala Leu Glu Thr Arg Val Ala Glu Leu Arg Gln Arg Val Gln Arg 
            20                  25                  30          


Leu Arg Asn Arg Val Ser Gln Tyr Arg Thr Arg Tyr Gly Pro Leu Gly 
        35                  40                  45              


Gly Gly Lys 
    50      


<210>  14
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  14

Lys Pro Leu Pro Glu Val Thr Asp Glu Tyr 
1               5                   10  


<210>  15
<211>  20
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa can be alanine or serine

<400>  15

Leu Glu Lys Glu Ala Leu Lys Lys Ile Ile Glu Asp Gln Gln Glu Xaa 
1               5                   10                  15      


Leu Asn Lys Trp 
            20  


<210>  16
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  16

Leu Glu Lys Glu Ala Leu Lys Lys Ile Ile Glu Asp Gln Gln Glu Ala 
1               5                   10                  15      


Leu Asn Lys Trp 
            20  


<210>  17
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized scFv VL chain


<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (35)..(35)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (61)..(61)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (101)..(101)
<223>  Xaa can be any naturally occurring amino acid

<400>  17

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Xaa Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Arg Thr Xaa Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Xaa Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Asn Leu Xaa Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Leu 
            100                 105                 110         


Lys 
    


<210>  18
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized scFv VH chain

<400>  18

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr His Tyr 
            20                  25                  30          


Tyr Ile Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Val Asn Pro Ser Asn Gly Gly Thr His Phe Asn Glu Lys Phe 
    50                  55                  60                  


Lys Ser Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Glu Tyr Asp Tyr Gly Leu Gly Phe Ala Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  19
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized scFv VL chain

<400>  19

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Arg Thr Pro Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Lys Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Asn Leu Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210>  20
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized scFv VH chain

<400>  20

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Phe 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Gln Ile Arg Asn Lys Pro Asn Asn Tyr Glu Thr Tyr Tyr Ser Asp 
    50                  55                  60                  


Ser Leu Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ile 
65                  70                  75                  80  


Thr Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Thr Leu Gly Asn Ser Trp Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  21
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized scFv VL chain

<400>  21

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Arg Ser Ser Gln Ser Leu Leu Asp Ser 
            20                  25                  30          


Arg Thr Lys Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Asn Leu Pro Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210>  22
<211>  115
<212>  PRT
<213>  Mus musculus

<400>  22

Asp Ile Val Leu Thr Gln Thr Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Thr Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Leu Thr 
                85                  90                  95      


Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Ala Asp Ala Ala Pro 
            100                 105                 110         


Thr Val Ser 
        115 


<210>  23
<211>  117
<212>  PRT
<213>  Mus musculus

<400>  23

Glu Val Lys Leu Gln Glu Ser Gly Pro Glu Leu Val Lys Ser Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Lys Tyr 
            20                  25                  30          


Val Ile His Trp Val Lys Gln Lys Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Tyr Asn Asp Val Ser Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Arg Gly Lys Ala Thr Leu Thr Ser Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ser Arg Asn Lys Asp Tyr Tyr Pro Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Ser Val Thr Val Ser 
        115         


<210>  24
<211>  105
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized scFv VL chain

<400>  24

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu 
65                  70                  75                  80  


Asp Phe Ala Val Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Leu Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile 
            100                 105 


<210>  25
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized scFv VH chain

<400>  25

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Lys Tyr 
            20                  25                  30          


Val Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Tyr Ile Asn Pro Tyr Asn Asp Val Ser Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Arg Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asn Lys Asp Tyr Tyr Pro Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser 
        115         


<210>  26
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized antibody VL chain

<400>  26

Tyr Glu Leu Ile Gln Pro Ser Ser Ala Ser Val Thr Val Gly Glu Thr 
1               5                   10                  15      


Val Lys Ile Thr Cys Ser Gly Asp Gln Leu Pro Lys Asn Phe Ala Tyr 
            20                  25                  30          


Trp Phe Gln Gln Lys Ser Asp Lys Asn Ile Leu Leu Leu Ile Tyr Met 
        35                  40                  45              


Asp Asn Lys Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser Thr 
    50                  55                  60                  


Ser Gly Thr Thr Ala Thr Leu Thr Ile Ser Gly Ala Gln Pro Glu Asp 
65                  70                  75                  80  


Glu Ala Ala Tyr Tyr Cys Leu Ser Ser Tyr Gly Asp Asn Asn Asp Leu 
                85                  90                  95      


Val Phe Gly Ser Gly Thr Gln Leu Thr Val Leu Arg 
            100                 105             


<210>  27
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized antibody VH chain

<400>  27

Glu Val Tyr Leu Val Glu Ser Gly Gly Asp Leu Val Gln Pro Gly Ser 
1               5                   10                  15      


Ser Leu Lys Val Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Phe 
            20                  25                  30          


Trp Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Lys Asn Ile Pro Asn Asn Tyr Ala Thr Glu Tyr Ala Asp 
    50                  55                  60                  


Ser Val Arg Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Arg Asn Ser 
65                  70                  75                  80  


Ile Tyr Leu Gln Met Asn Arg Leu Arg Val Asp Asp Thr Ala Ile Tyr 
                85                  90                  95      


Tyr Cys Thr Arg Ala Gly Arg Phe Asp His Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Met Val Thr Val Ser Ser Ala 
        115                 120     


<210>  28
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized antibody VL chain

<400>  28

Ser Tyr Val Leu Thr Gln Pro Ser Ser Val Ser Val Ala Pro Gly Gln 
1               5                   10                  15      


Thr Ala Thr Ile Ser Cys Gly Gly His Asn Ile Gly Ser Lys Asn Val 
            20                  25                  30          


His Trp Tyr Gln Gln Arg Pro Gly Gln Ser Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Gln Asp Asn Lys Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Met 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Asn Tyr Ser Val Leu 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105     


<210>  29
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized antibody VH chain

<400>  29

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ser Ala Tyr Tyr Tyr Asp Phe Ala Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  30
<211>  335
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein Escherichia coli and herpes simplex virus

<400>  30

Met Ser Arg Leu Asp Lys Ser Lys Val Ile Asn Ser Ala Leu Glu Leu 
1               5                   10                  15      


Leu Asn Glu Val Gly Ile Glu Gly Leu Thr Thr Arg Lys Leu Ala Gln 
            20                  25                  30          


Lys Leu Gly Val Glu Gln Pro Thr Leu Tyr Trp His Val Lys Asn Lys 
        35                  40                  45              


Arg Ala Leu Leu Asp Ala Leu Ala Ile Glu Met Leu Asp Arg His His 
    50                  55                  60                  


Thr His Phe Cys Pro Leu Lys Gly Glu Ser Trp Gln Asp Phe Leu Arg 
65                  70                  75                  80  


Asn Asn Ala Lys Ser Phe Arg Cys Ala Leu Leu Ser His Arg Asn Gly 
                85                  90                  95      


Ala Lys Val His Ser Asp Thr Arg Pro Thr Glu Lys Gln Tyr Glu Thr 
            100                 105                 110         


Leu Glu Asn Gln Leu Ala Phe Leu Cys Gln Gln Gly Phe Ser Leu Glu 
        115                 120                 125             


Asn Ala Leu Tyr Ala Leu Ser Ala Val Gly His Phe Thr Leu Gly Cys 
    130                 135                 140                 


Val Leu Glu Asp Gln Glu His Gln Val Ala Lys Glu Glu Arg Glu Thr 
145                 150                 155                 160 


Pro Thr Thr Asp Ser Met Pro Pro Leu Leu Arg Gln Ala Ile Glu Leu 
                165                 170                 175     


Phe Asp His Gln Gly Ala Glu Pro Ala Phe Leu Phe Gly Leu Glu Leu 
            180                 185                 190         


Ile Ile Cys Gly Leu Glu Lys Gln Leu Lys Cys Glu Ser Gly Ser Ala 
        195                 200                 205             


Tyr Ser Arg Ala Arg Thr Lys Asn Asn Tyr Gly Ser Thr Ile Glu Gly 
    210                 215                 220                 


Leu Leu Asp Leu Pro Asp Asp Asp Ala Pro Glu Glu Ala Gly Leu Ala 
225                 230                 235                 240 


Ala Pro Arg Leu Ser Phe Leu Pro Ala Gly His Thr Arg Arg Leu Ser 
                245                 250                 255     


Thr Ala Pro Pro Thr Asp Val Ser Leu Gly Asp Glu Leu His Leu Asp 
            260                 265                 270         


Gly Glu Asp Val Ala Met Ala His Ala Asp Ala Leu Asp Asp Phe Asp 
        275                 280                 285             


Leu Asp Met Leu Gly Asp Gly Asp Ser Pro Gly Pro Gly Phe Thr Pro 
    290                 295                 300                 


His Asp Ser Ala Pro Tyr Gly Ala Leu Asp Met Ala Asp Phe Glu Phe 
305                 310                 315                 320 


Glu Gln Met Phe Thr Asp Ala Leu Gly Ile Asp Glu Tyr Gly Gly 
                325                 330                 335 


<210>  31
<211>  248
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein Escherichia coli and herpes simplex virus

<400>  31

Met Ser Arg Leu Asp Lys Ser Lys Val Ile Asn Gly Ala Leu Glu Leu 
1               5                   10                  15      


Leu Asn Gly Val Gly Ile Glu Gly Leu Thr Thr Arg Lys Leu Ala Gln 
            20                  25                  30          


Lys Leu Gly Val Glu Gln Pro Thr Leu Tyr Trp His Val Lys Asn Lys 
        35                  40                  45              


Arg Ala Leu Leu Asp Ala Leu Pro Ile Glu Met Leu Asp Arg His His 
    50                  55                  60                  


Thr His Phe Cys Pro Leu Glu Gly Glu Ser Trp Gln Asp Phe Leu Arg 
65                  70                  75                  80  


Asn Asn Ala Lys Ser Phe Arg Cys Ala Leu Leu Ser His Arg Asp Gly 
                85                  90                  95      


Ala Lys Val His Leu Gly Thr Arg Pro Thr Glu Lys Gln Tyr Glu Thr 
            100                 105                 110         


Leu Glu Asn Gln Leu Ala Phe Leu Cys Gln Gln Gly Phe Ser Leu Glu 
        115                 120                 125             


Asn Ala Leu Tyr Ala Leu Ser Ala Val Gly His Phe Thr Leu Gly Cys 
    130                 135                 140                 


Val Leu Glu Glu Gln Glu His Gln Val Ala Lys Glu Glu Arg Glu Thr 
145                 150                 155                 160 


Pro Thr Thr Asp Ser Met Pro Pro Leu Leu Arg Gln Ala Ile Glu Leu 
                165                 170                 175     


Phe Asp Arg Gln Gly Ala Glu Pro Ala Phe Leu Phe Gly Leu Glu Leu 
            180                 185                 190         


Ile Ile Cys Gly Leu Glu Lys Gln Leu Lys Cys Glu Ser Gly Gly Pro 
        195                 200                 205             


Ala Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Pro Ala Asp Ala 
    210                 215                 220                 


Leu Asp Asp Phe Asp Leu Asp Met Leu Pro Ala Asp Ala Leu Asp Asp 
225                 230                 235                 240 


Phe Asp Leu Asp Met Leu Pro Gly 
                245             


<210>  32
<211>  248
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein Escherichia coli and herpes simplex virus

<400>  32

Met Ser Arg Leu Asp Lys Ser Lys Val Ile Asn Ser Ala Leu Glu Leu 
1               5                   10                  15      


Leu Asn Gly Val Gly Ile Glu Gly Leu Thr Thr Arg Lys Leu Ala Gln 
            20                  25                  30          


Lys Leu Gly Val Glu Gln Pro Thr Leu Tyr Trp His Val Lys Asn Lys 
        35                  40                  45              


Arg Ala Leu Leu Asp Ala Leu Pro Ile Glu Met Leu Asp Arg His His 
    50                  55                  60                  


Thr His Ser Cys Pro Leu Glu Gly Glu Ser Trp Gln Asp Phe Leu Arg 
65                  70                  75                  80  


Asn Asn Ala Lys Ser Tyr Arg Cys Ala Leu Leu Ser His Arg Asp Gly 
                85                  90                  95      


Ala Lys Val His Leu Gly Thr Arg Pro Thr Glu Lys Gln Tyr Glu Thr 
            100                 105                 110         


Leu Glu Asn Gln Leu Ala Phe Leu Cys Gln Gln Gly Phe Ser Leu Glu 
        115                 120                 125             


Asn Ala Leu Tyr Ala Leu Ser Ala Val Gly His Phe Thr Leu Gly Cys 
    130                 135                 140                 


Val Leu Glu Glu Gln Glu His Gln Val Ala Lys Glu Glu Arg Glu Thr 
145                 150                 155                 160 


Pro Thr Thr Asp Ser Met Pro Pro Leu Leu Lys Gln Ala Ile Glu Leu 
                165                 170                 175     


Phe Asp Arg Gln Gly Ala Glu Pro Ala Phe Leu Phe Gly Leu Glu Leu 
            180                 185                 190         


Ile Ile Cys Gly Leu Glu Lys Gln Leu Lys Cys Glu Ser Gly Gly Pro 
        195                 200                 205             


Thr Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Pro Ala Asp Ala 
    210                 215                 220                 


Leu Asp Asp Phe Asp Leu Asp Met Leu Pro Ala Asp Ala Leu Asp Asp 
225                 230                 235                 240 


Phe Asp Leu Asp Met Leu Pro Gly 
                245             


<210>  33
<211>  19
<212>  DNA
<213>  Escherichia coli

<400>  33
tccctatcag tgatagaga                                                    19


<210>  34
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Spacer sequence

<400>  34
acgatgtcga gtttac                                                       16


<210>  35
<211>  379
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TRE sequence

<400>  35
gagtttactc cctatcagtg atagagaacg tatgaagagt ttactcccta tcagtgatag       60

agaacgtatg cagactttac tccctatcag tgatagagaa cgtataagga gtttactccc      120

tatcagtgat agagaacgta tgaccagttt actccctatc agtgatagag aacgtatcta      180

cagtttactc cctatcagtg atagagaacg tatatccagt ttactcccta tcagtgatag      240

agaacgtata agctttaggc gtgtacggtg ggcgcctata aaagcagagc tcgtttagtg      300

aaccgtcaga tcgcctggag caattccaca acacttttgt cttataccaa ctttccgtac      360

cacttcctac cctcgtaaa                                                   379


<210>  36
<211>  30
<212>  DNA
<213>  Homo sapiens

<400>  36
ggaggaaaaa ctgtttcata cagaaggcgt                                        30


<210>  37
<211>  52
<212>  DNA
<213>  Homo sapiens

<400>  37
cagaattaac agtataaatt gcatctcttg ttcaagagtt ccctatcact ct               52


<210>  38
<211>  110
<212>  DNA
<213>  Homo sapiens

<400>  38
acattttgac acccccataa tatttttcca gaattaacag tataaattgc atctcttgtt       60

caagagttcc ctatcactct ctttaatcac tactcacagt aacctcaact                 110


<210>  39
<211>  232
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Fusion of human DNA sequences

<400>  39
ggaggaaaaa ctgtttcata cagaaggcgt ggaggaaaaa ctgtttcata cagaaggcgt       60

ggaggaaaaa ctgtttcata cagaaggcgt ggaggaaaaa ctgtttcata cagaaggcgt      120

ggaggaaaaa ctgtttcata cagaaggcgt ggaggaaaaa ctgtttcata cagaaggcgt      180

cagaattaac agtataaatt gcatctcttg ttcaagagtt ccctatcact ct              232


<210>  40
<211>  296
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Fusion of human DNA sequences

<400>  40
aggaggaaaa actgtttcat acagaaggcg taggaggaaa aactgtttca tacagaaggc       60

gtaggaggaa aaactgtttc atacagaagg cgtaggagga aaaactgttt catacagaag      120

gcgtaggagg aaaaactgtt tcatacagaa ggcgtaggag gaaaaactgt ttcatacaga      180

aggcgtacat tttgacaccc ccataatatt tttccagaat taacagtata aattgcatct      240

cttgttcaag agttccctat cactctcttt aatcactact cacagtaacc tcaact          296


<210>  41
<211>  627
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized homo sapiens/mus musculus chimera

<400>  41

Met Arg Arg Met Gln Leu Leu Leu Leu Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Glu Phe Gln Val Gln Leu Val Gln Ser Gly Ala Glu 
            20                  25                  30          


Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
        35                  40                  45              


Tyr Thr Phe Thr His Tyr Tyr Ile Tyr Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Gln Gly Leu Glu Trp Met Gly Gly Val Asn Pro Ser Asn Gly Gly Thr 
65                  70                  75                  80  


His Phe Asn Glu Lys Phe Lys Ser Arg Val Thr Met Thr Arg Asp Thr 
                85                  90                  95      


Ser Ile Ser Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg Ser Asp Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Arg Ser Glu Tyr Asp Tyr Gly Leu Gly 
        115                 120                 125             


Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val 
145                 150                 155                 160 


Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly Glu Arg Ala 
                165                 170                 175     


Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser Arg Thr Pro 
            180                 185                 190         


Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys 
        195                 200                 205             


Leu Leu Ile Tyr Trp Ala Ser Thr Arg Lys Ser Gly Val Pro Asp Arg 
    210                 215                 220                 


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
225                 230                 235                 240 


Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln Ser Tyr Asn 
                245                 250                 255     


Leu Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Ala Ala Ala 
            260                 265                 270         


Leu Glu Lys Glu Ala Leu Lys Lys Ile Ile Glu Asp Gln Gln Glu Ala 
        275                 280                 285             


Leu Asn Lys Trp Ala Ala Ala Gly Pro Gly Gly Gly Gly Ser Lys Ile 
    290                 295                 300                 


Leu Val Lys Gln Ser Pro Met Leu Val Ala Tyr Asp Asn Ala Val Asn 
305                 310                 315                 320 


Leu Ser Cys Lys Tyr Ser Tyr Asn Leu Phe Ser Arg Glu Phe Arg Ala 
                325                 330                 335     


Ser Leu His Lys Gly Leu Asp Ser Ala Val Glu Val Cys Val Val Tyr 
            340                 345                 350         


Gly Asn Tyr Ser Gln Gln Leu Gln Val Tyr Ser Lys Thr Gly Phe Asn 
        355                 360                 365             


Cys Asp Gly Lys Leu Gly Asn Glu Ser Val Thr Phe Tyr Leu Gln Asn 
    370                 375                 380                 


Leu Tyr Val Asn Gln Thr Asp Ile Tyr Phe Cys Lys Ile Glu Val Met 
385                 390                 395                 400 


Ala Pro Pro Pro Ala Leu Asp Asn Glu Lys Ser Asn Gly Thr Ile Ile 
                405                 410                 415     


His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro 
            420                 425                 430         


Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys 
        435                 440                 445             


Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser 
    450                 455                 460                 


Lys Arg Ser Arg Gly Gly His Ser Asp Tyr Met Asn Met Thr Pro Arg 
465                 470                 475                 480 


Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg 
                485                 490                 495     


Asp Phe Ala Ala Tyr Arg Ser Gly Gly Gly Gly Ser Gly Gly Gly Ala 
            500                 505                 510         


Ser Gly Gly Gly Gly Ser Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
        515                 520                 525             


Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
    530                 535                 540                 


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
545                 550                 555                 560 


Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu 
                565                 570                 575     


Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys 
            580                 585                 590         


Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu 
        595                 600                 605             


Ser Thr Ala Thr Lys Asp Thr Tyr Gly Ala Leu His Met Gln Ala Leu 
    610                 615                 620                 


Pro Pro Arg 
625         


<210>  42
<211>  532
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized homo sapiens/mus musculus chimera

<400>  42

Met Arg Arg Met Gln Leu Leu Leu Leu Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Glu Phe Gln Val Gln Leu Val Gln Ser Gly Ala Glu 
            20                  25                  30          


Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
        35                  40                  45              


Tyr Thr Phe Thr His Tyr Tyr Ile Tyr Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Gln Gly Leu Glu Trp Met Gly Gly Val Asn Pro Ser Asn Gly Gly Thr 
65                  70                  75                  80  


His Phe Asn Glu Lys Phe Lys Ser Arg Val Thr Met Thr Arg Asp Thr 
                85                  90                  95      


Ser Ile Ser Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg Ser Asp Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Arg Ser Glu Tyr Asp Tyr Gly Leu Gly 
        115                 120                 125             


Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val 
145                 150                 155                 160 


Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly Glu Arg Ala 
                165                 170                 175     


Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser Arg Thr Pro 
            180                 185                 190         


Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys 
        195                 200                 205             


Leu Leu Ile Tyr Trp Ala Ser Thr Arg Lys Ser Gly Val Pro Asp Arg 
    210                 215                 220                 


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
225                 230                 235                 240 


Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln Ser Tyr Asn 
                245                 250                 255     


Leu Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Ala Ala Ala 
            260                 265                 270         


Leu Glu Lys Glu Ala Leu Lys Lys Ile Ile Glu Asp Gln Gln Glu Ala 
        275                 280                 285             


Leu Asn Lys Trp Ala Ala Ala Gly Pro Gly Gly Gly Gly Ser Thr Thr 
    290                 295                 300                 


Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln 
305                 310                 315                 320 


Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala 
                325                 330                 335     


Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala 
            340                 345                 350         


Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr 
        355                 360                 365             


Leu Tyr Cys Gly Gly Gly Gly Ser Lys Arg Gly Arg Lys Lys Leu Leu 
    370                 375                 380                 


Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu 
385                 390                 395                 400 


Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys 
                405                 410                 415     


Glu Leu Gly Gly Gly Gly Ser Phe Ser Arg Ser Ala Asp Ala Pro Ala 
            420                 425                 430         


Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg 
        435                 440                 445             


Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu 
    450                 455                 460                 


Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
465                 470                 475                 480 


Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
                485                 490                 495     


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
            500                 505                 510         


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
        515                 520                 525             


Leu Pro Pro Arg 
    530         


<210>  43
<211>  615
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized homo sapiens/mus musculus chimera

<400>  43

Met Arg Arg Met Gln Leu Leu Leu Leu Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Glu Phe Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
            20                  25                  30          


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
        35                  40                  45              


Phe Thr Phe Ser Asp Phe Trp Met Asn Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Lys Gly Leu Glu Trp Val Gly Gln Ile Arg Asn Lys Pro Asn Asn Tyr 
65                  70                  75                  80  


Glu Thr Tyr Tyr Ser Asp Ser Leu Lys Gly Arg Phe Thr Ile Ser Arg 
                85                  90                  95      


Asp Asp Ser Lys Ser Ile Thr Tyr Leu Gln Met Asn Ser Leu Arg Ala 
            100                 105                 110         


Glu Asp Thr Ala Val Tyr Tyr Cys Thr Leu Gly Asn Ser Trp Phe Ala 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr 
145                 150                 155                 160 


Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly Glu Arg Ala Thr Ile 
                165                 170                 175     


Asn Cys Arg Ser Ser Gln Ser Leu Leu Asp Ser Arg Thr Lys Lys Asn 
            180                 185                 190         


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu 
        195                 200                 205             


Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val Pro Asp Arg Phe Ser 
    210                 215                 220                 


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln 
225                 230                 235                 240 


Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln Ser Tyr Asn Leu Pro 
                245                 250                 255     


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Ala Ala Ala Lys Pro 
            260                 265                 270         


Leu Pro Glu Val Thr Asp Glu Tyr Ala Ala Ala Gly Pro Gly Gly Gly 
        275                 280                 285             


Gly Ser Lys Ile Leu Val Lys Gln Ser Pro Met Leu Val Ala Tyr Asp 
    290                 295                 300                 


Asn Ala Val Asn Leu Ser Cys Lys Tyr Ser Tyr Asn Leu Phe Ser Arg 
305                 310                 315                 320 


Glu Phe Arg Ala Ser Leu His Lys Gly Leu Asp Ser Ala Val Glu Val 
                325                 330                 335     


Cys Val Val Tyr Gly Asn Tyr Ser Gln Gln Leu Gln Val Tyr Ser Lys 
            340                 345                 350         


Thr Gly Phe Asn Cys Asp Gly Lys Leu Gly Asn Glu Ser Val Thr Phe 
        355                 360                 365             


Tyr Leu Gln Asn Leu Tyr Val Asn Gln Thr Asp Ile Tyr Phe Cys Lys 
    370                 375                 380                 


Ile Glu Val Met Ala Pro Pro Pro Ala Leu Asp Asn Glu Lys Ser Asn 
385                 390                 395                 400 


Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu 
                405                 410                 415     


Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly 
            420                 425                 430         


Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe 
        435                 440                 445             


Trp Val Arg Ser Lys Arg Ser Arg Gly Gly His Ser Asp Tyr Met Asn 
    450                 455                 460                 


Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr 
465                 470                 475                 480 


Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Gly Gly Gly Gly Ser 
                485                 490                 495     


Gly Gly Gly Ala Ser Gly Gly Gly Gly Ser Phe Ser Arg Ser Ala Asp 
            500                 505                 510         


Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn 
        515                 520                 525             


Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg 
    530                 535                 540                 


Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly 
545                 550                 555                 560 


Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu 
                565                 570                 575     


Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu 
            580                 585                 590         


Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Gly Ala Leu His 
        595                 600                 605             


Met Gln Ala Leu Pro Pro Arg 
    610                 615 


<210>  44
<211>  520
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized homo sapiens/mus musculus chimera

<400>  44

Met Arg Arg Met Gln Leu Leu Leu Leu Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Glu Phe Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
            20                  25                  30          


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
        35                  40                  45              


Phe Thr Phe Ser Asp Phe Trp Met Asn Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Lys Gly Leu Glu Trp Val Gly Gln Ile Arg Asn Lys Pro Asn Asn Tyr 
65                  70                  75                  80  


Glu Thr Tyr Tyr Ser Asp Ser Leu Lys Gly Arg Phe Thr Ile Ser Arg 
                85                  90                  95      


Asp Asp Ser Lys Ser Ile Thr Tyr Leu Gln Met Asn Ser Leu Arg Ala 
            100                 105                 110         


Glu Asp Thr Ala Val Tyr Tyr Cys Thr Leu Gly Asn Ser Trp Phe Ala 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr 
145                 150                 155                 160 


Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly Glu Arg Ala Thr Ile 
                165                 170                 175     


Asn Cys Arg Ser Ser Gln Ser Leu Leu Asp Ser Arg Thr Lys Lys Asn 
            180                 185                 190         


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu 
        195                 200                 205             


Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val Pro Asp Arg Phe Ser 
    210                 215                 220                 


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln 
225                 230                 235                 240 


Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln Ser Tyr Asn Leu Pro 
                245                 250                 255     


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Ala Ala Ala Lys Pro 
            260                 265                 270         


Leu Pro Glu Val Thr Asp Glu Tyr Ala Ala Ala Gly Pro Gly Gly Gly 
        275                 280                 285             


Gly Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr 
    290                 295                 300                 


Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala 
305                 310                 315                 320 


Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile 
                325                 330                 335     


Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser 
            340                 345                 350         


Leu Val Ile Thr Leu Tyr Cys Gly Gly Gly Gly Ser Lys Arg Gly Arg 
        355                 360                 365             


Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln 
    370                 375                 380                 


Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu 
385                 390                 395                 400 


Glu Gly Gly Cys Glu Leu Gly Gly Gly Gly Ser Phe Ser Arg Ser Ala 
                405                 410                 415     


Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu 
            420                 425                 430         


Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly 
        435                 440                 445             


Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu 
    450                 455                 460                 


Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser 
465                 470                 475                 480 


Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly 
                485                 490                 495     


Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu 
            500                 505                 510         


His Met Gln Ala Leu Pro Pro Arg 
        515                 520 


<210>  45
<211>  367
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized homo sapiens/mus musculus chimera

<400>  45

Met Arg Arg Met Gln Leu Leu Leu Leu Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Glu Phe Lys Pro Leu Pro Glu Val Thr Asp Glu Tyr 
            20                  25                  30          


Ala Ala Ala Gly Pro Gly Gly Gly Gly Ser Lys Ile Leu Val Lys Gln 
        35                  40                  45              


Ser Pro Met Leu Val Ala Tyr Asp Asn Ala Val Asn Leu Ser Cys Lys 
    50                  55                  60                  


Tyr Ser Tyr Asn Leu Phe Ser Arg Glu Phe Arg Ala Ser Leu His Lys 
65                  70                  75                  80  


Gly Leu Asp Ser Ala Val Glu Val Cys Val Val Tyr Gly Asn Tyr Ser 
                85                  90                  95      


Gln Gln Leu Gln Val Tyr Ser Lys Thr Gly Phe Asn Cys Asp Gly Lys 
            100                 105                 110         


Leu Gly Asn Glu Ser Val Thr Phe Tyr Leu Gln Asn Leu Tyr Val Asn 
        115                 120                 125             


Gln Thr Asp Ile Tyr Phe Cys Lys Ile Glu Val Met Ala Pro Pro Pro 
    130                 135                 140                 


Ala Leu Asp Asn Glu Lys Ser Asn Gly Thr Ile Ile His Val Lys Gly 
145                 150                 155                 160 


Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe 
                165                 170                 175     


Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu 
            180                 185                 190         


Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg 
        195                 200                 205             


Gly Gly His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro 
    210                 215                 220                 


Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala 
225                 230                 235                 240 


Tyr Arg Ser Gly Gly Gly Gly Ser Gly Gly Gly Ala Ser Gly Gly Gly 
                245                 250                 255     


Gly Ser Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln 
            260                 265                 270         


Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp 
        275                 280                 285             


Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro 
    290                 295                 300                 


Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp 
305                 310                 315                 320 


Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg 
                325                 330                 335     


Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr 
            340                 345                 350         


Lys Asp Thr Tyr Gly Ala Leu His Met Gln Ala Leu Pro Pro Arg 
        355                 360                 365         


<210>  46
<211>  379
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized homo sapiens/mus musculus chimera

<400>  46

Met Arg Arg Met Gln Leu Leu Leu Leu Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Glu Phe Lys Pro Leu Pro Glu Val Thr Asp Glu Tyr 
            20                  25                  30          


Ala Ala Ala Gly Pro Gly Gly Gly Gly Ser Lys Ile Leu Val Lys Gln 
        35                  40                  45              


Ser Pro Met Leu Val Ala Tyr Asp Asn Ala Val Asn Leu Ser Cys Lys 
    50                  55                  60                  


Tyr Ser Tyr Asn Leu Phe Ser Arg Glu Phe Arg Ala Ser Leu His Lys 
65                  70                  75                  80  


Gly Leu Asp Ser Ala Val Glu Val Cys Val Val Tyr Gly Asn Tyr Ser 
                85                  90                  95      


Gln Gln Leu Gln Val Tyr Ser Lys Thr Gly Phe Asn Cys Asp Gly Lys 
            100                 105                 110         


Leu Gly Asn Glu Ser Val Thr Phe Tyr Leu Gln Asn Leu Tyr Val Asn 
        115                 120                 125             


Gln Thr Asp Ile Tyr Phe Cys Lys Ile Glu Val Met Ala Pro Pro Pro 
    130                 135                 140                 


Ala Leu Asp Asn Glu Lys Ser Asn Gly Thr Ile Ile His Val Lys Gly 
145                 150                 155                 160 


Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe 
                165                 170                 175     


Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu 
            180                 185                 190         


Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg 
        195                 200                 205             


Gly Gly Gly Gly Ser Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe 
    210                 215                 220                 


Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly 
225                 230                 235                 240 


Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Gly 
                245                 250                 255     


Gly Gly Gly Ser Gly Gly Gly Ala Ser Gly Gly Gly Gly Ser Phe Ser 
            260                 265                 270         


Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr 
        275                 280                 285             


Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys 
    290                 295                 300                 


Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn 
305                 310                 315                 320 


Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu 
                325                 330                 335     


Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly 
            340                 345                 350         


His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr 
        355                 360                 365             


Gly Ala Leu His Met Gln Ala Leu Pro Pro Arg 
    370                 375                 


<210>  47
<211>  375
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized homo sapiens/mus musculus chimera

<400>  47

Met Arg Arg Met Gln Leu Leu Leu Leu Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Glu Phe Glu Lys Glu Ala Leu Lys Lys Ile Ile Glu 
            20                  25                  30          


Asp Gln Gln Glu Ser Leu Asn Lys Ala Ala Ala Gly Pro Gly Gly Gly 
        35                  40                  45              


Gly Ser Lys Ile Leu Val Lys Gln Ser Pro Met Leu Val Ala Tyr Asp 
    50                  55                  60                  


Asn Ala Val Asn Leu Ser Cys Lys Tyr Ser Tyr Asn Leu Phe Ser Arg 
65                  70                  75                  80  


Glu Phe Arg Ala Ser Leu His Lys Gly Leu Asp Ser Ala Val Glu Val 
                85                  90                  95      


Cys Val Val Tyr Gly Asn Tyr Ser Gln Gln Leu Gln Val Tyr Ser Lys 
            100                 105                 110         


Thr Gly Phe Asn Cys Asp Gly Lys Leu Gly Asn Glu Ser Val Thr Phe 
        115                 120                 125             


Tyr Leu Gln Asn Leu Tyr Val Asn Gln Thr Asp Ile Tyr Phe Cys Lys 
    130                 135                 140                 


Ile Glu Val Met Ala Pro Pro Pro Ala Leu Asp Asn Glu Lys Ser Asn 
145                 150                 155                 160 


Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu 
                165                 170                 175     


Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly 
            180                 185                 190         


Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe 
        195                 200                 205             


Trp Val Arg Ser Lys Arg Ser Arg Gly Gly His Ser Asp Tyr Met Asn 
    210                 215                 220                 


Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr 
225                 230                 235                 240 


Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Gly Gly Gly Gly Ser 
                245                 250                 255     


Gly Gly Gly Ala Ser Gly Gly Gly Gly Ser Phe Ser Arg Ser Ala Asp 
            260                 265                 270         


Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn 
        275                 280                 285             


Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg 
    290                 295                 300                 


Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly 
305                 310                 315                 320 


Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu 
                325                 330                 335     


Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu 
            340                 345                 350         


Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Gly Ala Leu His 
        355                 360                 365             


Met Gln Ala Leu Pro Pro Arg 
    370                 375 


<210>  48
<211>  387
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized homo sapiens/mus musculus chimera

<400>  48

Met Arg Arg Met Gln Leu Leu Leu Leu Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Glu Phe Glu Lys Glu Ala Leu Lys Lys Ile Ile Glu 
            20                  25                  30          


Asp Gln Gln Glu Ser Leu Asn Lys Ala Ala Ala Gly Pro Gly Gly Gly 
        35                  40                  45              


Gly Ser Lys Ile Leu Val Lys Gln Ser Pro Met Leu Val Ala Tyr Asp 
    50                  55                  60                  


Asn Ala Val Asn Leu Ser Cys Lys Tyr Ser Tyr Asn Leu Phe Ser Arg 
65                  70                  75                  80  


Glu Phe Arg Ala Ser Leu His Lys Gly Leu Asp Ser Ala Val Glu Val 
                85                  90                  95      


Cys Val Val Tyr Gly Asn Tyr Ser Gln Gln Leu Gln Val Tyr Ser Lys 
            100                 105                 110         


Thr Gly Phe Asn Cys Asp Gly Lys Leu Gly Asn Glu Ser Val Thr Phe 
        115                 120                 125             


Tyr Leu Gln Asn Leu Tyr Val Asn Gln Thr Asp Ile Tyr Phe Cys Lys 
    130                 135                 140                 


Ile Glu Val Met Ala Pro Pro Pro Ala Leu Asp Asn Glu Lys Ser Asn 
145                 150                 155                 160 


Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu 
                165                 170                 175     


Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly 
            180                 185                 190         


Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe 
        195                 200                 205             


Trp Val Arg Ser Lys Arg Ser Arg Gly Gly Gly Gly Ser Lys Arg Gly 
    210                 215                 220                 


Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val 
225                 230                 235                 240 


Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu 
                245                 250                 255     


Glu Glu Gly Gly Cys Glu Leu Gly Gly Gly Gly Ser Gly Gly Gly Ala 
            260                 265                 270         


Ser Gly Gly Gly Gly Ser Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
        275                 280                 285             


Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
    290                 295                 300                 


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
305                 310                 315                 320 


Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu 
                325                 330                 335     


Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys 
            340                 345                 350         


Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu 
        355                 360                 365             


Ser Thr Ala Thr Lys Asp Thr Tyr Gly Ala Leu His Met Gln Ala Leu 
    370                 375                 380                 


Pro Pro Arg 
385         


<210>  49
<211>  1881
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  humanized homo sapiens/mus musculus chimera

<400>  49
atgcgccgca tgcagctgct gcttctgatc gctctgagcc tggctcttgt gaccaactct       60

gaattccagg tgcagctggt gcagagcgga gccgaggtga agaagcctgg agcctctgtg      120

aaggtgagct gcaaggcttc tggctacacc ttcacccact actacatcta ctgggtgaga      180

caggctcccg gacagggcct ggagtggatg ggaggcgtga accccagcaa cggaggcacc      240

cacttcaacg agaagttcaa gtctcgcgtg accatgaccc gcgacaccag catctctacc      300

gcttacatgg agctgagccg cctgcgctct gatgataccg ctgtgtacta ctgcgctcgc      360

agcgagtacg attacggact gggcttcgcc tactggggcc agggaaccct ggtgaccgtg      420

agctctggag gcggaggcag cggaggcggc ggatctggag gcggaggaag cgatatcgtg      480

atgacccagt ctcctgatag cctggctgtg agcctgggcg agagagctac catcaactgc      540

aagagcagcc agagcctgct gaactctcgc acccctaaga actaccttgc ttggtaccag      600

cagaagcctg gacagccccc taagctgctg atctactggg cttctacccg caagagcggc      660

gtgcccgaca gattctctgg cagcggaagc ggcaccgatt tcaccctgac catcagcagc      720

ctgcaggctg aggacgtggc cgtgtactac tgcaagcagt cttacaacct gctgaccttc      780

ggaggcggaa ccaaggtgga gatcaaggct gccgctctgg agaaggaggc cctgaagaag      840

atcatcgagg atcagcagga ggctctgaac aagtgggctg ccgctgggcc cggaggaggc      900

ggcagcaaga tcctggtcaa acagtcccct atgctggtcg cttacgacaa cgccgttaat      960

ctgagttgca aatatagtta caacctgttt agccgggaat ttcgcgcatc tctccacaag     1020

ggactggatt ctgcggttga ggtttgtgtg gtctatggca attatagcca gcaactgcaa     1080

gtgtacagca aaacaggctt taactgcgac gggaaactcg ggaacgaatc agtgaccttc     1140

tatctgcaga acctgtacgt taaccaaaca gatatttact tctgcaagat agaggtgatg     1200

gctccaccgc cagcactgga taacgagaag tccaatggaa ccatcattca cgtcaagggg     1260

aagcatctgt gtccttcccc gttgttccct gggccgagca aacccttttg ggtgcttgtg     1320

gtagttggcg gggtattggc ctgctattcc cttctcgtaa ctgtggcctt catcatcttc     1380

tgggtcagat ctaagaggtc taggggcggg catagcgact acatgaacat gacacccagg     1440

cggcctggcc ccactcgcaa acactaccag ccatacgcac caccaagaga ctttgccgca     1500

tatcggagtg gtggcggcgg gtcaggaggt ggagctagcg gtggaggagg ttccttctct     1560

aggtcagctg atgctcccgc ctatcagcaa ggtcagaacc agctctacaa tgagctgaat     1620

ctgggacgtc gggaggagta cgacgtgctg gataaacgaa gaggacgcga tcccgagatg     1680

ggtgggaagc ctaggcgcaa gaatccccag gaaggcctct acaatgaact gcagaaagac     1740

aagatggccg aagcctacag cgagattggc atgaaagggg agcgacggag aggaaaggga     1800

catgacgggt tgtatcaggg tctttccact gcgacaaagg atacctatgg ggctctgcac     1860

atgcaagcac tgccacctag a                                               1881


<210>  50
<211>  1596
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  humanized homo sapiens/mus musculus chimera

<400>  50
atgcgccgca tgcagctgct gcttctgatc gctctgagcc tggctcttgt gaccaactct       60

gaattccagg tgcagctggt gcagagcgga gccgaggtga agaagcctgg agcctctgtg      120

aaggtgagct gcaaggcttc tggctacacc ttcacccact actacatcta ctgggtgaga      180

caggctcccg gacagggcct ggagtggatg ggaggcgtga accccagcaa cggaggcacc      240

cacttcaacg agaagttcaa gtctcgcgtg accatgaccc gcgacaccag catctctacc      300

gcttacatgg agctgagccg cctgcgctct gatgataccg ctgtgtacta ctgcgctcgc      360

agcgagtacg attacggact gggcttcgcc tactggggcc agggaaccct ggtgaccgtg      420

agctctggag gcggaggcag cggaggcggc ggatctggag gcggaggaag cgatatcgtg      480

atgacccagt ctcctgatag cctggctgtg agcctgggcg agagagctac catcaactgc      540

aagagcagcc agagcctgct gaactctcgc acccctaaga actaccttgc ttggtaccag      600

cagaagcctg gacagccccc taagctgctg atctactggg cttctacccg caagagcggc      660

gtgcccgaca gattctctgg cagcggaagc ggcaccgatt tcaccctgac catcagcagc      720

ctgcaggctg aggacgtggc cgtgtactac tgcaagcagt cttacaacct gctgaccttc      780

ggaggcggaa ccaaggtgga gatcaaggct gccgctctgg agaaggaggc cctgaagaag      840

atcatcgagg atcagcagga ggctctgaac aagtgggctg ccgctgggcc cggaggaggc      900

gggtcaacca ctacccctgc tcccaggcct cctacacccg cgccaacgat tgccagtcaa      960

cctctgtccc tgaggcctga agcctgcaga ccagctgcag gcggtgctgt gcatacacgg     1020

ggcttggact ttgcctgcga tatctacatc tgggcacctc ttgccgggac ttgtggcgtt     1080

ctcctgcttt ctctggtcat taccctgtac tgtggaggcg gcggtagcaa acgcggacgg     1140

aagaaactgc tgtacatctt caagcagccc ttcatgcgcc ccgtgcagac aacacaggaa     1200

gaggacggtt gcagctgccg atttcccgaa gaggaggagg gaggctgtga attgggcgga     1260

ggaggctcct tctctcgcag tgcagatgcc ccagcgtaca agcaaggcca gaaccagctg     1320

tacaacgagc tcaatctggg gcgtagagag gagtatgacg tgctggacaa gaggcgagga     1380

agggaccccg agatgggtgg caaaccgcgg cgtaagaatc cgcaggaagg cctctacaac     1440

gagctgcaga aagacaagat ggccgaagcc tattccgaga tagggatgaa aggggaaaga     1500

cggcgcggta aagggcacga tgggctctat cagggtctga gcactgcaac caaggacacg     1560

tatgatgcct tgcacatgca agctcttcca ccaaga                               1596


<210>  51
<211>  1845
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  humanized homo sapiens/mus musculus chimera

<400>  51
atgcgccgca tgcagctgct gcttctgatc gctctgagcc tggctcttgt gaccaactct       60

gaattcgagg tgcaactggt cgaaagtggc ggtggtttag ttcagcctgg tggaagtcta      120

cggcttagct gcgcagcatc cggtttcacc tttagcgact tttggatgaa ctgggttcgg      180

caggctccgg gcaaaggact ggagtgggtt gggcaaatcc gcaacaaacc gaataactac      240

gaaacttatt actcagatag cctgaagggt cgattcacca tcagcaggga tgattcaaag      300

tcaatcactt acctacagat gaactcatta agagcggagg atactgcggt gtattactgt      360

acactaggta actcctggtt cgcgtattgg ggacagggca cccttgtaac cgtctccagc      420

ggaggcggag gcagcggagg cggcggatct ggaggcggag gaagcgacat tgttatgacc      480

cagagcccgg actctctcgc tgttagtctt ggtgagcgag cgactattaa ctgccggagc      540

agtcagagtt tgttggactc tcggacgaaa aagaactacc tggcatggta ccagcagaag      600

ccgggccaac cacctaaatt actgatatat tgggcgtcga ctcgtgagtc aggggtaccg      660

gacaggtttt ctggaagcgg atcaggaaca gacttcactt tgacgatctc ttcgcttcaa      720

gccgaggacg ttgcggttta ttattgtaag caaagctata atctgccgac atttggtggc      780

ggcaccaagg ttgaaattaa ggctgccgct aagcctctgc ctgaagtgac cgatgagtat      840

gctgccgctg ggcccggagg aggcggcagc aagatcctgg tcaaacagtc ccctatgctg      900

gtcgcttacg acaacgccgt taatctgagt tgcaaatata gttacaacct gtttagccgg      960

gaatttcgcg catctctcca caagggactg gattctgcgg ttgaggtttg tgtggtctat     1020

ggcaattata gccagcaact gcaagtgtac agcaaaacag gctttaactg cgacgggaaa     1080

ctcgggaacg aatcagtgac cttctatctg cagaacctgt acgttaacca aacagatatt     1140

tacttctgca agatagaggt gatggctcca ccgccagcac tggataacga gaagtccaat     1200

ggaaccatca ttcacgtcaa ggggaagcat ctgtgtcctt ccccgttgtt ccctgggccg     1260

agcaaaccct tttgggtgct tgtggtagtt ggcggggtat tggcctgcta ttcccttctc     1320

gtaactgtgg ccttcatcat cttctgggtc agatctaaga ggtctagggg cgggcatagc     1380

gactacatga acatgacacc caggcggcct ggccccactc gcaaacacta ccagccatac     1440

gcaccaccaa gagactttgc cgcatatcgg agtggtggcg gcgggtcagg aggtggagct     1500

agcggtggag gaggttcctt ctctaggtca gctgatgctc ccgcctatca gcaaggtcag     1560

aaccagctct acaatgagct gaatctggga cgtcgggagg agtacgacgt gctggataaa     1620

cgaagaggac gcgatcccga gatgggtggg aagcctaggc gcaagaatcc ccaggaaggc     1680

ctctacaatg aactgcagaa agacaagatg gccgaagcct acagcgagat tggcatgaaa     1740

ggggagcgac ggagaggaaa gggacatgac gggttgtatc agggtctttc cactgcgaca     1800

aaggatacct atggggctct gcacatgcaa gcactgccac ctaga                     1845


<210>  52
<211>  1563
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  humanized homo sapiens/mus musculus chimera

<400>  52
atgcgccgca tgcagctgct gcttctgatc gctctgagcc tggctcttgt gaccaactct       60

gaattcgagg tgcaactggt cgaaagtggc ggtggtttag ttcagcctgg tggaagtcta      120

cggcttagct gcgcagcatc cggtttcacc tttagcgact tttggatgaa ctgggttcgg      180

caggctccgg gcaaaggact ggagtgggtt gggcaaatcc gcaacaaacc gaataactac      240

gaaacttatt actcagatag cctgaagggt cgattcacca tcagcaggga tgattcaaag      300

tcaatcactt acctacagat gaactcatta agagcggagg atactgcggt gtattactgt      360

acactaggta actcctggtt cgcgtattgg ggacagggca cccttgtaac cgtctccagc      420

ggaggcggag gcagcggagg cggcggatct ggaggcggag gaagcgacat tgttatgacc      480

cagagcccgg actctctcgc tgttagtctt ggtgagcgag cgactattaa ctgccggagc      540

agtcagagtt tgttggactc tcggacgaaa aagaactacc tggcatggta ccagcagaag      600

ccgggccaac cacctaaatt actgatatat tgggcgtcga ctcgtgagtc aggggtaccg      660

gacaggtttt ctggaagcgg atcaggaaca gacttcactt tgacgatctc ttcgcttcaa      720

gccgaggacg ttgcggttta ttattgtaag caaagctata atctgccgac atttggtggc      780

ggcaccaagg ttgaaattaa ggctgccgct aagcctctgc ctgaagtgac cgatgagtat      840

gctgccgctg ggcccggagg aggcggcagc accactaccc ctgctcccag gcctcctaca      900

cccgcgccaa cgattgccag tcaacctctg tccctgaggc ctgaagcctg cagaccagct      960

gcaggcggtg ctgtgcatac acggggcttg gactttgcct gcgatatcta catctgggca     1020

cctcttgccg ggacttgtgg cgttctcctg ctttctctgg tcattaccct gtactgtgga     1080

ggcggcggta gcaaacgcgg acggaagaaa ctgctgtaca tcttcaagca gcccttcatg     1140

cgccccgtgc agacaacaca ggaagaggac ggttgcagct gccgatttcc cgaagaggag     1200

gagggaggct gtgaattggg cggaggaggc tccttctctc gcagtgcaga tgccccagcg     1260

tacaagcaag gccagaacca gctgtacaac gagctcaatc tggggcgtag agaggagtat     1320

gacgtgctgg acaagaggcg aggaagggac cccgagatgg gtggcaaacc gcggcgtaag     1380

aatccgcagg aaggcctcta caacgagctg cagaaagaca agatggccga agcctattcc     1440

gagataggga tgaaagggga aagacggcgc ggtaaagggc acgatgggct ctatcagggt     1500

ctgagcactg caaccaagga cacgtatgat gccttgcaca tgcaagctct tccaccaaga     1560

taa                                                                   1563


<210>  53
<211>  1101
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  humanized homo sapiens/mus musculus chimera

<400>  53
atgcgccgca tgcagctgct gcttctgatc gctctgagcc tggctcttgt gaccaactct       60

gaattcaaac ccctacctga agtgactgat gagtatgctg ccgctgggcc cggaggaggc      120

ggcagcaaga tcctggtcaa acagtcccct atgctggtcg cttacgacaa cgccgttaat      180

ctgagttgca aatatagtta caacctgttt agccgggaat ttcgcgcatc tctccacaag      240

ggactggatt ctgcggttga ggtttgtgtg gtctatggca attatagcca gcaactgcaa      300

gtgtacagca aaacaggctt taactgcgac gggaaactcg ggaacgaatc agtgaccttc      360

tatctgcaga acctgtacgt taaccaaaca gatatttact tctgcaagat agaggtgatg      420

gctccaccgc cagcactgga taacgagaag tccaatggaa ccatcattca cgtcaagggg      480

aagcatctgt gtccttcccc gttgttccct gggccgagca aacccttttg ggtgcttgtg      540

gtagttggcg gggtattggc ctgctattcc cttctcgtaa ctgtggcctt catcatcttc      600

tgggtcagat ctaagaggtc taggggcggg catagcgact acatgaacat gacacccagg      660

cggcctggcc ccactcgcaa acactaccag ccatacgcac caccaagaga ctttgccgca      720

tatcggagtg gtggcggcgg gtcaggaggt ggagctagcg gtggaggagg ttccttctct      780

aggtcagctg atgctcccgc ctatcagcaa ggtcagaacc agctctacaa tgagctgaat      840

ctgggacgtc gggaggagta cgacgtgctg gataaacgaa gaggacgcga tcccgagatg      900

ggtgggaagc ctaggcgcaa gaatccccag gaaggcctct acaatgaact gcagaaagac      960

aagatggccg aagcctacag cgagattggc atgaaagggg agcgacggag aggaaaggga     1020

catgacgggt tgtatcaggg tctttccact gcgacaaagg atacctatgg ggctctgcac     1080

atgcaagcac tgccacctag a                                               1101


<210>  54
<211>  1137
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  humanized homo sapiens/mus musculus chimera

<400>  54
atgcgccgca tgcagctgct gcttctgatc gctctgagcc tggctcttgt gaccaactct       60

gaattcaaac ccctacctga agtgactgat gagtatgctg ccgctgggcc cggaggaggc      120

ggcagcaaga tcctggtcaa acagtcccct atgctggtcg cttacgacaa cgccgttaat      180

ctgagttgca aatatagtta caacctgttt agccgggaat ttcgcgcatc tctccacaag      240

ggactggatt ctgcggttga ggtttgtgtg gtctatggca attatagcca gcaactgcaa      300

gtgtacagca aaacaggctt taactgcgac gggaaactcg ggaacgaatc agtgaccttc      360

tatctgcaga acctgtacgt taaccaaaca gatatttact tctgcaagat agaggtgatg      420

gctccaccgc cagcactgga taacgagaag tccaatggaa ccatcattca cgtcaagggg      480

aagcatctgt gtccttcccc gttgttccct gggccgagca aacccttttg ggtgcttgtg      540

gtagttggcg gggtattggc ctgctattcc cttctcgtaa ctgtggcctt catcatcttc      600

tgggtcagat ctaagaggtc taggggcggg ggcgggtcaa aacgcggacg gaagaaactg      660

ctgtacatct tcaagcagcc cttcatgcgc cccgtgcaga caacacagga agaggacggt      720

tgcagctgcc gatttcccga agaggaggag ggaggctgtg aattgggtgg cggcgggtca      780

ggaggtggag ctagcggtgg aggaggttcc ttctctaggt cagctgatgc tcccgcctat      840

cagcaaggtc agaaccagct ctacaatgag ctgaatctgg gacgtcggga ggagtacgac      900

gtgctggata aacgaagagg acgcgatccc gagatgggtg ggaagcctag gcgcaagaat      960

ccccaggaag gcctctacaa tgaactgcag aaagacaaga tggccgaagc ctacagcgag     1020

attggcatga aaggggagcg acggagagga aagggacatg acgggttgta tcagggtctt     1080

tccactgcga caaaggatac ctatggggct ctgcacatgc aagcactgcc acctaga        1137


<210>  55
<211>  1125
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  humanized homo sapiens/mus musculus chimera

<400>  55
atgcgccgca tgcagctgct gcttctgatc gctctgagcc tggctcttgt gaccaactct       60

gaattcgaga aagaagcact gaagaaaata atagaagacc aacaagaatc cctaaacaaa      120

gctgccgctg ggcccggagg aggcggcagc aagatcctgg tcaaacagtc ccctatgctg      180

gtcgcttacg acaacgccgt taatctgagt tgcaaatata gttacaacct gtttagccgg      240

gaatttcgcg catctctcca caagggactg gattctgcgg ttgaggtttg tgtggtctat      300

ggcaattata gccagcaact gcaagtgtac agcaaaacag gctttaactg cgacgggaaa      360

ctcgggaacg aatcagtgac cttctatctg cagaacctgt acgttaacca aacagatatt      420

tacttctgca agatagaggt gatggctcca ccgccagcac tggataacga gaagtccaat      480

ggaaccatca ttcacgtcaa ggggaagcat ctgtgtcctt ccccgttgtt ccctgggccg      540

agcaaaccct tttgggtgct tgtggtagtt ggcggggtat tggcctgcta ttcccttctc      600

gtaactgtgg ccttcatcat cttctgggtc agatctaaga ggtctagggg cgggcatagc      660

gactacatga acatgacacc caggcggcct ggccccactc gcaaacacta ccagccatac      720

gcaccaccaa gagactttgc cgcatatcgg agtggtggcg gcgggtcagg aggtggagct      780

agcggtggag gaggttcctt ctctaggtca gctgatgctc ccgcctatca gcaaggtcag      840

aaccagctct acaatgagct gaatctggga cgtcgggagg agtacgacgt gctggataaa      900

cgaagaggac gcgatcccga gatgggtggg aagcctaggc gcaagaatcc ccaggaaggc      960

ctctacaatg aactgcagaa agacaagatg gccgaagcct acagcgagat tggcatgaaa     1020

ggggagcgac ggagaggaaa gggacatgac gggttgtatc agggtctttc cactgcgaca     1080

aaggatacct atggggctct gcacatgcaa gcactgccac ctaga                     1125


<210>  56
<211>  1161
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  humanized homo sapiens/mus musculus chimera

<400>  56
atgcgccgca tgcagctgct gcttctgatc gctctgagcc tggctcttgt gaccaactct       60

gaattcgaga aagaagcact gaagaaaata atagaagacc aacaagaatc cctaaacaaa      120

gctgccgctg ggcccggagg aggcggcagc aagatcctgg tcaaacagtc ccctatgctg      180

gtcgcttacg acaacgccgt taatctgagt tgcaaatata gttacaacct gtttagccgg      240

gaatttcgcg catctctcca caagggactg gattctgcgg ttgaggtttg tgtggtctat      300

ggcaattata gccagcaact gcaagtgtac agcaaaacag gctttaactg cgacgggaaa      360

ctcgggaacg aatcagtgac cttctatctg cagaacctgt acgttaacca aacagatatt      420

tacttctgca agatagaggt gatggctcca ccgccagcac tggataacga gaagtccaat      480

ggaaccatca ttcacgtcaa ggggaagcat ctgtgtcctt ccccgttgtt ccctgggccg      540

agcaaaccct tttgggtgct tgtggtagtt ggcggggtat tggcctgcta ttcccttctc      600

gtaactgtgg ccttcatcat cttctgggtc agatctaaga ggtctagggg cgggggcggg      660

tcaaaacgcg gacggaagaa actgctgtac atcttcaagc agcccttcat gcgccccgtg      720

cagacaacac aggaagagga cggttgcagc tgccgatttc ccgaagagga ggagggaggc      780

tgtgaattgg gtggcggcgg gtcaggaggt ggagctagcg gtggaggagg ttccttctct      840

aggtcagctg atgctcccgc ctatcagcaa ggtcagaacc agctctacaa tgagctgaat      900

ctgggacgtc gggaggagta cgacgtgctg gataaacgaa gaggacgcga tcccgagatg      960

ggtgggaagc ctaggcgcaa gaatccccag gaaggcctct acaatgaact gcagaaagac     1020

aagatggccg aagcctacag cgagattggc atgaaagggg agcgacggag aggaaaggga     1080

catgacgggt tgtatcaggg tctttccact gcgacaaagg atacctatgg ggctctgcac     1140

atgcaagcac tgccacctag a                                               1161


<210>  57
<211>  274
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Tagged humanized scFv

<400>  57

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Ser 
            20                  25                  30          


Trp Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Trp Ile Ser Pro Tyr Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg His Trp Pro Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln 
    130                 135                 140                 


Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr 
145                 150                 155                 160 


Cys Arg Ala Ser Gln Asp Val Ser Thr Ala Val Ala Trp Tyr Gln Gln 
                165                 170                 175     


Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ser Ala Ser Phe Leu 
            180                 185                 190         


Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
        195                 200                 205             


Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr 
    210                 215                 220                 


Tyr Cys Gln Gln Tyr Leu Tyr His Pro Ala Thr Phe Gly Gln Gly Thr 
225                 230                 235                 240 


Lys Val Glu Ile Lys Ala Ala Ala Lys Pro Leu Pro Glu Val Thr Asp 
                245                 250                 255     


Glu Tyr Ala Arg Gly Gly Pro Gly Gly Gly Gly Ser His His His His 
            260                 265                 270         


His His 
        


<210>  58
<211>  278
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Tagged humanized scFv

<400>  58

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Tyr 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asn Ile Lys Gln Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gly Gly Trp Phe Gly Glu Leu Ala Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val 
    130                 135                 140                 


Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala 
145                 150                 155                 160 


Thr Leu Ser Cys Arg Ala Ser Gln Arg Val Ser Ser Ser Tyr Leu Ala 
                165                 170                 175     


Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Asp 
            180                 185                 190         


Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly 
        195                 200                 205             


Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp 
    210                 215                 220                 


Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Leu Pro Trp Thr Phe 
225                 230                 235                 240 


Gly Gln Gly Thr Lys Val Glu Ile Lys Ala Ala Ala Lys Pro Leu Pro 
                245                 250                 255     


Glu Val Thr Asp Glu Tyr Ala Arg Gly Gly Pro Gly Gly Gly Gly Ser 
            260                 265                 270         


His His His His His His 
        275             


<210>  59
<211>  302
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Tagged human sequences

<400>  59

Glu Phe Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro 
1               5                   10                  15      


Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
            20                  25                  30          


Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn 
        35                  40                  45              


Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe 
    50                  55                  60                  


Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr 
65                  70                  75                  80  


Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg 
                85                  90                  95      


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro 
            100                 105                 110         


Lys Ala Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val Thr Glu 
        115                 120                 125             


Arg Arg Ala Glu Val Pro Thr Ala His Ala Arg Gly Lys Pro Leu Pro 
    130                 135                 140                 


Glu Val Thr Asp Glu Tyr Ala Ala Ala Pro Gly Trp Phe Leu Asp Ser 
145                 150                 155                 160 


Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val 
                165                 170                 175     


Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr 
            180                 185                 190         


Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln 
        195                 200                 205             


Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln 
    210                 215                 220                 


Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His 
225                 230                 235                 240 


Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys 
                245                 250                 255     


Gly Ala Ile Ser Leu Ala Pro Lys Ala Gln Ile Lys Glu Ser Leu Arg 
            260                 265                 270         


Ala Glu Leu Arg Val Thr Glu Arg Arg Ala Glu Val Pro Thr Ala His 
        275                 280                 285             


Ala Ala Ala Gly Gly Gly Gly Ser His His His His His His 
    290                 295                 300         


<210>  60
<211>  532
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized homo sapiens/mus musculus chimera

<400>  60

Met Arg Arg Met Gln Leu Leu Leu Leu Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Glu Phe Gln Val Gln Leu Val Gln Ser Gly Ala Glu 
            20                  25                  30          


Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
        35                  40                  45              


Tyr Thr Phe Thr His Tyr Tyr Ile Tyr Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Gln Gly Leu Glu Trp Met Gly Gly Val Asn Pro Ser Asn Gly Gly Thr 
65                  70                  75                  80  


His Phe Asn Glu Lys Phe Lys Ser Arg Val Thr Met Thr Arg Asp Thr 
                85                  90                  95      


Ser Ile Ser Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg Ser Asp Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Arg Ser Glu Tyr Asp Tyr Gly Leu Gly 
        115                 120                 125             


Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val 
145                 150                 155                 160 


Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly Glu Arg Ala 
                165                 170                 175     


Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser Arg Thr Pro 
            180                 185                 190         


Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys 
        195                 200                 205             


Leu Leu Ile Tyr Trp Ala Ser Thr Arg Lys Ser Gly Val Pro Asp Arg 
    210                 215                 220                 


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
225                 230                 235                 240 


Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln Ser Tyr Asn 
                245                 250                 255     


Leu Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Ala Ala Ala 
            260                 265                 270         


Leu Glu Lys Glu Ala Leu Lys Lys Ile Ile Glu Asp Gln Gln Glu Ala 
        275                 280                 285             


Leu Asn Lys Trp Ala Ala Ala Gly Pro Gly Gly Gly Gly Ser Thr Thr 
    290                 295                 300                 


Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln 
305                 310                 315                 320 


Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala 
                325                 330                 335     


Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala 
            340                 345                 350         


Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr 
        355                 360                 365             


Leu Tyr Cys Gly Gly Gly Gly Ser Lys Arg Gly Arg Lys Lys Leu Leu 
    370                 375                 380                 


Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu 
385                 390                 395                 400 


Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys 
                405                 410                 415     


Glu Leu Gly Gly Gly Gly Ser Phe Ser Arg Ser Ala Asp Ala Pro Ala 
            420                 425                 430         


Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg 
        435                 440                 445             


Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu 
    450                 455                 460                 


Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
465                 470                 475                 480 


Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
                485                 490                 495     


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
            500                 505                 510         


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
        515                 520                 525             


Leu Pro Pro Arg 
    530         


<210>  61
<211>  450
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized VH chain

<400>  61

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ile Met Met Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Tyr Pro Ser Gly Gly Ile Thr Phe Tyr Ala Asp Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ile Lys Leu Gly Thr Val Thr Thr Val Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly Lys 
    450 


<210>  62
<211>  216
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized VL chain

<400>  62

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Asp Val Ser Asn Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Ser Ser 
                85                  90                  95      


Ser Thr Arg Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu Gly Gln 
            100                 105                 110         


Pro Lys Ala Asn Pro Thr Val Thr Leu Phe Pro Pro Ser Ser Glu Glu 
        115                 120                 125             


Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr 
    130                 135                 140                 


Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Gly Ser Pro Val Lys 
145                 150                 155                 160 


Ala Gly Val Glu Thr Thr Lys Pro Ser Lys Gln Ser Asn Asn Lys Tyr 
                165                 170                 175     


Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His 
            180                 185                 190         


Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys 
        195                 200                 205             


Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215     


<210>  63
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized VH chain

<400>  63

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Val Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Ile Arg Thr Gly Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Phe Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Met Lys Gly Ser Gly Thr Tyr Gly Gly Trp Phe Asp Thr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  64
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized VL chain

<400>  64

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Val Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Ile 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
            100                 105         


<210>  65
<211>  279
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Tagged humanized scFv

<400>  65

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Ser Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Leu Tyr His Pro Ala 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Ala Ser Ala Ala Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
    130                 135                 140                 


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr 
145                 150                 155                 160 


Phe Ser Asp Ser Trp Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly 
                165                 170                 175     


Leu Glu Trp Val Ala Trp Ile Ser Pro Tyr Gly Gly Ser Thr Tyr Tyr 
            180                 185                 190         


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys 
        195                 200                 205             


Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
    210                 215                 220                 


Val Tyr Tyr Cys Ala Arg Arg His Trp Pro Gly Gly Phe Asp Tyr Trp 
225                 230                 235                 240 


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ala Ala Lys Pro Leu 
                245                 250                 255     


Pro Glu Val Thr Asp Glu Tyr Ala Arg Gly Gly Pro Gly Gly Gly Gly 
            260                 265                 270         


Ser His His His His His His 
        275                 


<210>  66
<211>  283
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Tagged humanized scFv

<400>  66

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Arg Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Asp Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Leu Pro 
                85                  90                  95      


Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Ala Ser Ala Ala Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
    130                 135                 140                 


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
145                 150                 155                 160 


Thr Phe Ser Arg Tyr Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
                165                 170                 175     


Gly Leu Glu Trp Val Ala Asn Ile Lys Gln Asp Gly Ser Glu Lys Tyr 
            180                 185                 190         


Tyr Val Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
        195                 200                 205             


Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
    210                 215                 220                 


Ala Val Tyr Tyr Cys Ala Arg Glu Gly Gly Trp Phe Gly Glu Leu Ala 
225                 230                 235                 240 


Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ala 
                245                 250                 255     


Ala Lys Pro Leu Pro Glu Val Thr Asp Glu Tyr Ala Arg Gly Gly Pro 
            260                 265                 270         


Gly Gly Gly Gly Ser His His His His His His 
        275                 280             


<210>  67
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized VH chain

<400>  67

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Gly Phe Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Thr Ala Tyr Asn Gly Asn Thr Asn Tyr Ala Gln Lys Leu 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Tyr Phe Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  68
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized VL chain

<400>  68

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          


Leu Val Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Arg 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  69
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized VH chain

<400>  69

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asp Val His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Leu His Ala Asp Thr Gly Ile Thr Lys Phe Ser Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Arg Ile Gln Leu Trp Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  70
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized VL chain

<400>  70

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Glu Lys Ala Pro Lys Ser Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  71
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized VH chain

<400>  71

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Glu Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Leu Phe Gly Ile Ala His Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Asp Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Lys Tyr Ser Tyr Val Ser Gly Ser Pro Phe Gly Met Asp Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  72
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized VL chain

<400>  72

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
            100                 105     


<210>  73
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized VH chain

<400>  73

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Ser Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Asp Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Ala Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Ser Ser Gly Trp Ser Arg Tyr Tyr Met Asp Val Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210>  74
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized VL chain

<400>  74

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210>  75
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized VH chain

<400>  75

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Val Ser Gly Gly Ile Phe Ser Thr Tyr 
            20                  25                  30          


Ala Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn His Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gln Gly Ile Ala Ala Ala Leu Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  76
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized VL chain

<400>  76

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 
                85                  90                  95      


Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  77
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized VH chain

<400>  77

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ile Thr Phe Asp Asp Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Arg Gly Arg Ile Glu Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Arg Phe Arg Tyr Phe Asp Trp Phe Leu Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  78
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized VL chain

<400>  78

Ala Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Ala 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Phe Asn Ser Tyr Pro Phe 
                85                  90                  95      


Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 
            100                 105         


<210>  79
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized VH chain

<400>  79

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Val Val His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Gly Asn Ser Gly Asn Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Val Pro Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser 
    


<210>  80
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized VL chain

<400>  80

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Glu Lys Ala Pro Lys Ser Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  81
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized VH chain

<400>  81

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Thr Ser Gly Asp Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Arg Ala His Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Lys Phe His Phe Val Ser Gly Ser Pro Phe Gly Met Asp Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  82
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized VL chain

<400>  82

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210>  83
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized VH chain

<400>  83

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Thr Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Lys Ala His Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Thr Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Lys Tyr Asp Tyr Val Ser Gly Ser Pro Phe Gly Met Asp Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  84
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized VL chain

<400>  84

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210>  85
<211>  273
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Tagged humanized scFv

<400>  85

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Thr Ser Gly Asp Thr Phe Ser Thr Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Lys Ala His Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Lys Phe His Phe Val Ser Gly Ser Pro Phe Gly Met Asp Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Leu Thr Gln 
    130                 135                 140                 


Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser 
145                 150                 155                 160 


Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala Trp Tyr Gln Gln 
                165                 170                 175     


Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Asp Ala Ser Asn Arg 
            180                 185                 190         


Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
        195                 200                 205             


Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr 
    210                 215                 220                 


Tyr Cys Gln Gln Arg Ser Asn Trp Pro Thr Phe Gly Gln Gly Thr Lys 
225                 230                 235                 240 


Val Glu Ile Lys Ala Ala Ala Lys Pro Leu Pro Glu Val Thr Asp Glu 
                245                 250                 255     


Tyr Ala Arg Gly Gly Pro Gly Gly Gly Gly Ser His His His His His 
            260                 265                 270         


His 
    


<210>  86
<211>  273
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Tagged humanized scFv

<400>  86

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Thr Ser Gly Asp Thr Phe Ser Thr Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Lys Ala His Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Lys Phe His Phe Val Ser Gly Ser Pro Phe Gly Met Asp Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Leu Thr Gln 
    130                 135                 140                 


Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser 
145                 150                 155                 160 


Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala Trp Tyr Gln Gln 
                165                 170                 175     


Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Asp Ala Ser Asn Arg 
            180                 185                 190         


Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
        195                 200                 205             


Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr 
    210                 215                 220                 


Tyr Cys Gln Gln Arg Ser Asn Trp Pro Thr Phe Gly Gln Gly Thr Lys 
225                 230                 235                 240 


Val Glu Ile Lys Ala Ala Ala Lys Pro Leu Pro Glu Val Thr Asp Glu 
                245                 250                 255     


Tyr Ala Arg Gly Gly Pro Gly Gly Gly Gly Ser His His His His His 
            260                 265                 270         


His 
    


<210>  87
<211>  271
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Tagged humanized scFv

<400>  87

Gly Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly 
1               5                   10                  15      


Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp 
            20                  25                  30          


Tyr Gly Phe Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp 
        35                  40                  45              


Met Gly Trp Ile Thr Ala Tyr Asn Gly Asn Thr Asn Tyr Ala Gln Lys 
    50                  55                  60                  


Leu Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Val 
65                  70                  75                  80  


Tyr Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Asp Tyr Phe Tyr Gly Met Asp Val Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu 
    130                 135                 140                 


Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln 
145                 150                 155                 160 


Ser Val Ser Ser Tyr Leu Val Trp Tyr Gln Gln Lys Pro Gly Gln Ala 
                165                 170                 175     


Pro Arg Leu Leu Ile Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro 
            180                 185                 190         


Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
        195                 200                 205             


Ser Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg 
    210                 215                 220                 


Ser Asn Trp Pro Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
225                 230                 235                 240 


Ala Ala Ala Lys Pro Leu Pro Glu Val Thr Asp Glu Tyr Ala Arg Gly 
                245                 250                 255     


Gly Pro Gly Gly Gly Gly Ser His His His His His His His His 
            260                 265                 270     


<210>  88
<211>  280
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Tagged humanized scFv

<400>  88

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          


Leu Val Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Arg 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Ala Ser Ala Ala Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys 
    130                 135                 140                 


Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr 
145                 150                 155                 160 


Phe Thr Asp Tyr Gly Phe Ser Trp Val Arg Gln Ala Pro Gly Gln Gly 
                165                 170                 175     


Leu Glu Trp Met Gly Trp Ile Thr Ala Tyr Asn Gly Asn Thr Asn Tyr 
            180                 185                 190         


Ala Gln Lys Leu Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr 
        195                 200                 205             


Ser Thr Val Tyr Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala 
    210                 215                 220                 


Val Tyr Tyr Cys Ala Arg Asp Tyr Phe Tyr Gly Met Asp Val Trp Gly 
225                 230                 235                 240 


Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ala Ala Lys Pro Leu Pro 
                245                 250                 255     


Glu Val Thr Asp Glu Tyr Ala Arg Gly Gly Pro Gly Gly Gly Gly Ser 
            260                 265                 270         


His His His His His His His His 
        275                 280 


<210>  89
<211>  272
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Tagged humanized scFv

<400>  89

Gly Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly 
1               5                   10                  15      


Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser 
            20                  25                  30          


Tyr Asp Val His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp 
        35                  40                  45              


Met Gly Trp Leu His Ala Asp Thr Gly Ile Thr Lys Phe Ser Gln Lys 
    50                  55                  60                  


Phe Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala 
65                  70                  75                  80  


Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Glu Arg Ile Gln Leu Trp Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser 
    130                 135                 140                 


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser 
145                 150                 155                 160 


Gln Gly Ile Ser Ser Trp Leu Ala Trp Tyr Gln Gln Lys Pro Glu Lys 
                165                 170                 175     


Ala Pro Lys Ser Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val 
            180                 185                 190         


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
        195                 200                 205             


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln 
    210                 215                 220                 


Tyr Asn Ser Tyr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
225                 230                 235                 240 


Lys Ala Ala Ala Lys Pro Leu Pro Glu Val Thr Asp Glu Tyr Ala Arg 
                245                 250                 255     


Gly Gly Pro Gly Gly Gly Gly Ser His His His His His His His His 
            260                 265                 270         


<210>  90
<211>  281
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Tagged humanized scFv

<400>  90

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Glu Lys Ala Pro Lys Ser Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Ala Ser Ala Ala Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys 
    130                 135                 140                 


Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr 
145                 150                 155                 160 


Phe Thr Ser Tyr Asp Val His Trp Val Arg Gln Ala Pro Gly Gln Arg 
                165                 170                 175     


Leu Glu Trp Met Gly Trp Leu His Ala Asp Thr Gly Ile Thr Lys Phe 
            180                 185                 190         


Ser Gln Lys Phe Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala 
        195                 200                 205             


Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala 
    210                 215                 220                 


Val Tyr Tyr Cys Ala Arg Glu Arg Ile Gln Leu Trp Phe Asp Tyr Trp 
225                 230                 235                 240 


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ala Ala Lys Pro Leu 
                245                 250                 255     


Pro Glu Val Thr Asp Glu Tyr Ala Arg Gly Gly Pro Gly Gly Gly Gly 
            260                 265                 270         


Ser His His His His His His His His 
        275                 280     


<210>  91
<211>  276
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Tagged humanized scFv

<400>  91

Gly Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Glu Pro Gly 
1               5                   10                  15      


Ser Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Ser 
            20                  25                  30          


Tyr Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp 
        35                  40                  45              


Met Gly Gly Ile Ile Pro Leu Phe Gly Ile Ala His Tyr Ala Gln Lys 
    50                  55                  60                  


Phe Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Asn Thr Ala 
65                  70                  75                  80  


Tyr Met Asp Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Lys Tyr Ser Tyr Val Ser Gly Ser Pro Phe Gly Met Asp 
            100                 105                 110         


Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Leu Thr 
    130                 135                 140                 


Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu 
145                 150                 155                 160 


Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala Trp Tyr Gln 
                165                 170                 175     


Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Asp Ala Ser Asn 
            180                 185                 190         


Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr 
        195                 200                 205             


Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala Val 
    210                 215                 220                 


Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Thr Phe Gly Gln Gly Thr 
225                 230                 235                 240 


Arg Leu Glu Ile Lys Ala Ala Ala Lys Pro Leu Pro Glu Val Thr Asp 
                245                 250                 255     


Glu Tyr Ala Arg Gly Gly Pro Gly Gly Gly Gly Ser His His His His 
            260                 265                 270         


His His His His 
        275     


<210>  92
<211>  285
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Tagged humanized scFv

<400>  92

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Gly Gly Gly Gly Ser Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Ala Ser Ala Ala Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Glu 
    130                 135                 140                 


Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe 
145                 150                 155                 160 


Asn Ser Tyr Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
                165                 170                 175     


Glu Trp Met Gly Gly Ile Ile Pro Leu Phe Gly Ile Ala His Tyr Ala 
            180                 185                 190         


Gln Lys Phe Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Asn 
        195                 200                 205             


Thr Ala Tyr Met Asp Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val 
    210                 215                 220                 


Tyr Tyr Cys Ala Arg Lys Tyr Ser Tyr Val Ser Gly Ser Pro Phe Gly 
225                 230                 235                 240 


Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ala 
                245                 250                 255     


Ala Lys Pro Leu Pro Glu Val Thr Asp Glu Tyr Ala Arg Gly Gly Pro 
            260                 265                 270         


Gly Gly Gly Gly Ser His His His His His His His His 
        275                 280                 285 


<210>  93
<211>  274
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Tagged humanized scFv

<400>  93

Gly Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly 
1               5                   10                  15      


Ser Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser 
            20                  25                  30          


Tyr Ala Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp 
        35                  40                  45              


Met Gly Gly Ile Ile Pro Ile Phe Gly Ser Ala Asn Tyr Ala Gln Lys 
    50                  55                  60                  


Phe Gln Asp Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Ala Ala 
65                  70                  75                  80  


Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Asp Ser Ser Gly Trp Ser Arg Tyr Tyr Met Asp Val Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Leu Thr Gln Ser 
    130                 135                 140                 


Pro Gly Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys 
145                 150                 155                 160 


Arg Ala Ser Gln Ser Val Ser Ser Ser Tyr Leu Ala Trp Tyr Gln Gln 
                165                 170                 175     


Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ala Ser Ser Arg 
            180                 185                 190         


Ala Thr Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
        195                 200                 205             


Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr 
    210                 215                 220                 


Tyr Cys Gln Gln Tyr Gly Ser Ser Pro Phe Gly Gly Gly Thr Lys Val 
225                 230                 235                 240 


Glu Ile Lys Ala Ala Ala Lys Pro Leu Pro Glu Val Thr Asp Glu Tyr 
                245                 250                 255     


Ala Arg Gly Gly Pro Gly Gly Gly Gly Ser His His His His His His 
            260                 265                 270         


His His 
        


<210>  94
<211>  283
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Tagged humanized scFv

<400>  94

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Ala Ser Ala Ala Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
    130                 135                 140                 


Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe 
145                 150                 155                 160 


Ser Ser Tyr Ala Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
                165                 170                 175     


Glu Trp Met Gly Gly Ile Ile Pro Ile Phe Gly Ser Ala Asn Tyr Ala 
            180                 185                 190         


Gln Lys Phe Gln Asp Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser 
        195                 200                 205             


Ala Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val 
    210                 215                 220                 


Tyr Tyr Cys Ala Arg Asp Ser Ser Gly Trp Ser Arg Tyr Tyr Met Asp 
225                 230                 235                 240 


Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ala Ala Lys 
                245                 250                 255     


Pro Leu Pro Glu Val Thr Asp Glu Tyr Ala Arg Gly Gly Pro Gly Gly 
            260                 265                 270         


Gly Gly Ser His His His His His His His His 
        275                 280             


<210>  95
<211>  275
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Tagged humanized scFv

<400>  95

Gly Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly 
1               5                   10                  15      


Ser Ser Val Lys Val Ser Cys Lys Val Ser Gly Gly Ile Phe Ser Thr 
            20                  25                  30          


Tyr Ala Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp 
        35                  40                  45              


Met Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn His Ala Gln Lys 
    50                  55                  60                  


Phe Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala 
65                  70                  75                  80  


Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Asp Gln Gly Ile Ala Ala Ala Leu Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Leu Thr Gln Ser Pro 
    130                 135                 140                 


Gly Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg 
145                 150                 155                 160 


Ala Ser Gln Ser Val Ser Ser Ser Tyr Leu Ala Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ala Ser Ser Arg Ala 
            180                 185                 190         


Thr Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
        195                 200                 205             


Thr Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr 
    210                 215                 220                 


Cys Gln Gln Tyr Gly Ser Ser Pro Trp Thr Phe Gly Gln Gly Thr Lys 
225                 230                 235                 240 


Val Glu Ile Lys Ala Ala Ala Lys Pro Leu Pro Glu Val Thr Asp Glu 
                245                 250                 255     


Tyr Ala Arg Gly Gly Pro Gly Gly Gly Gly Ser His His His His His 
            260                 265                 270         


His His His 
        275 


<210>  96
<211>  284
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Tagged humanized scFv

<400>  96

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 
                85                  90                  95      


Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Ala Ser Ala Ala Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val 
    130                 135                 140                 


Lys Lys Pro Gly Ser Ser Val Lys Val Ser Cys Lys Val Ser Gly Gly 
145                 150                 155                 160 


Ile Phe Ser Thr Tyr Ala Ile Asn Trp Val Arg Gln Ala Pro Gly Gln 
                165                 170                 175     


Gly Leu Glu Trp Met Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn 
            180                 185                 190         


His Ala Gln Lys Phe Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser 
        195                 200                 205             


Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr 
    210                 215                 220                 


Ala Val Tyr Tyr Cys Ala Arg Asp Gln Gly Ile Ala Ala Ala Leu Phe 
225                 230                 235                 240 


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ala Ala 
                245                 250                 255     


Lys Pro Leu Pro Glu Val Thr Asp Glu Tyr Ala Arg Gly Gly Pro Gly 
            260                 265                 270         


Gly Gly Gly Ser His His His His His His His His 
        275                 280                 


<210>  97
<211>  275
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Tagged humanized scFv

<400>  97

Gly Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
1               5                   10                  15      


Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ile Thr Phe Asp Asp 
            20                  25                  30          


Tyr Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Val Ser Gly Ile Ser Trp Asn Arg Gly Arg Ile Glu Tyr Ala Asp Ser 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr 
                85                  90                  95      


Cys Ala Lys Gly Arg Phe Arg Tyr Phe Asp Trp Phe Leu Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Ile Gln Leu Thr Gln Ser 
    130                 135                 140                 


Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys 
145                 150                 155                 160 


Arg Ala Ser Gln Gly Ile Ser Ser Ala Leu Ala Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Asp Ala Ser Ser Leu Glu 
            180                 185                 190         


Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
        195                 200                 205             


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr 
    210                 215                 220                 


Cys Gln Gln Phe Asn Ser Tyr Pro Phe Thr Phe Gly Pro Gly Thr Lys 
225                 230                 235                 240 


Val Asp Ile Lys Ala Ala Ala Lys Pro Leu Pro Glu Val Thr Asp Glu 
                245                 250                 255     


Tyr Ala Arg Gly Gly Pro Gly Gly Gly Gly Ser His His His His His 
            260                 265                 270         


His His His 
        275 


<210>  98
<211>  284
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Tagged humanized scFv

<400>  98

Ala Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Ala 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Phe Asn Ser Tyr Pro Phe 
                85                  90                  95      


Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Ala Ser Ala Ala Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
    130                 135                 140                 


Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ile Thr 
145                 150                 155                 160 


Phe Asp Asp Tyr Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly 
                165                 170                 175     


Leu Glu Trp Val Ser Gly Ile Ser Trp Asn Arg Gly Arg Ile Glu Tyr 
            180                 185                 190         


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys 
        195                 200                 205             


Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
    210                 215                 220                 


Leu Tyr Tyr Cys Ala Lys Gly Arg Phe Arg Tyr Phe Asp Trp Phe Leu 
225                 230                 235                 240 


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ala Ala 
                245                 250                 255     


Lys Pro Leu Pro Glu Val Thr Asp Glu Tyr Ala Arg Gly Gly Pro Gly 
            260                 265                 270         


Gly Gly Gly Ser His His His His His His His His 
        275                 280                 


<210>  99
<211>  266
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Tagged humanized scFv

<400>  99

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Val Val His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Gly Asn Ser Gly Asn Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Val Pro Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
    130                 135                 140                 


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp 
145                 150                 155                 160 


Leu Ala Trp Tyr Gln Gln Lys Pro Glu Lys Ala Pro Lys Ser Leu Ile 
                165                 170                 175     


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
            180                 185                 190         


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
        195                 200                 205             


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Tyr 
    210                 215                 220                 


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Ala Ala Ala Lys Pro 
225                 230                 235                 240 


Leu Pro Glu Val Thr Asp Glu Tyr Ala Arg Gly Gly Pro Gly Gly Gly 
                245                 250                 255     


Gly Ser His His His His His His His His 
            260                 265     


<210>  100
<211>  276
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Tagged humanized scFv

<400>  100

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Glu Lys Ala Pro Lys Ser Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Ala Ser Ala Ala Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
    130                 135                 140                 


Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Thr 
145                 150                 155                 160 


Phe Asp Asp Tyr Val Val His Trp Val Arg Gln Ala Pro Gly Lys Gly 
                165                 170                 175     


Leu Glu Trp Val Ser Gly Ile Ser Gly Asn Ser Gly Asn Ile Gly Tyr 
            180                 185                 190         


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys 
        195                 200                 205             


Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
    210                 215                 220                 


Leu Tyr Tyr Cys Ala Val Pro Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
225                 230                 235                 240 


Val Thr Val Ser Ser Ala Ala Ala Lys Pro Leu Pro Glu Val Thr Asp 
                245                 250                 255     


Glu Tyr Ala Arg Gly Gly Pro Gly Gly Gly Gly Ser His His His His 
            260                 265                 270         


His His His His 
        275     


<210>  101
<211>  276
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Tagged humanized scFv

<400>  101

Gly Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly 
1               5                   10                  15      


Ser Ser Val Lys Val Ser Cys Lys Thr Ser Gly Asp Thr Phe Ser Ser 
            20                  25                  30          


Tyr Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp 
        35                  40                  45              


Met Gly Gly Ile Ile Pro Ile Phe Gly Arg Ala His Tyr Ala Gln Lys 
    50                  55                  60                  


Phe Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala 
65                  70                  75                  80  


Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Phe 
                85                  90                  95      


Cys Ala Arg Lys Phe His Phe Val Ser Gly Ser Pro Phe Gly Met Asp 
            100                 105                 110         


Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Leu Thr 
    130                 135                 140                 


Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu 
145                 150                 155                 160 


Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala Trp Tyr Gln 
                165                 170                 175     


Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Asp Ala Ser Asn 
            180                 185                 190         


Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr 
        195                 200                 205             


Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala Val 
    210                 215                 220                 


Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Thr Phe Gly Gln Gly Thr 
225                 230                 235                 240 


Lys Val Glu Ile Lys Ala Ala Ala Lys Pro Leu Pro Glu Val Thr Asp 
                245                 250                 255     


Glu Tyr Ala Arg Gly Gly Pro Gly Gly Gly Gly Ser His His His His 
            260                 265                 270         


His His His His 
        275     


<210>  102
<211>  285
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Tagged humanized scFv

<400>  102

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Ala Ser Ala Ala Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
    130                 135                 140                 


Pro Gly Ser Ser Val Lys Val Ser Cys Lys Thr Ser Gly Asp Thr Phe 
145                 150                 155                 160 


Ser Ser Tyr Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
                165                 170                 175     


Glu Trp Met Gly Gly Ile Ile Pro Ile Phe Gly Arg Ala His Tyr Ala 
            180                 185                 190         


Gln Lys Phe Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser 
        195                 200                 205             


Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val 
    210                 215                 220                 


Tyr Phe Cys Ala Arg Lys Phe His Phe Val Ser Gly Ser Pro Phe Gly 
225                 230                 235                 240 


Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ala 
                245                 250                 255     


Ala Lys Pro Leu Pro Glu Val Thr Asp Glu Tyr Ala Arg Gly Gly Pro 
            260                 265                 270         


Gly Gly Gly Gly Ser His His His His His His His His 
        275                 280                 285 


<210>  103
<211>  276
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Tagged humanized scFv

<400>  103

Gly Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly 
1               5                   10                  15      


Ser Ser Val Lys Val Ser Cys Lys Thr Ser Gly Gly Thr Phe Ser Ser 
            20                  25                  30          


Tyr Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp 
        35                  40                  45              


Met Gly Gly Ile Ile Pro Ile Phe Gly Lys Ala His Tyr Ala Gln Lys 
    50                  55                  60                  


Phe Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Thr Thr Ala 
65                  70                  75                  80  


Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Lys Tyr Asp Tyr Val Ser Gly Ser Pro Phe Gly Met Asp 
            100                 105                 110         


Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Leu Thr 
    130                 135                 140                 


Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu 
145                 150                 155                 160 


Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala Trp Tyr Gln 
                165                 170                 175     


Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Asp Ala Ser Asn 
            180                 185                 190         


Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr 
        195                 200                 205             


Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala Val 
    210                 215                 220                 


Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Thr Phe Gly Gln Gly Thr 
225                 230                 235                 240 


Lys Val Glu Ile Lys Ala Ala Ala Lys Pro Leu Pro Glu Val Thr Asp 
                245                 250                 255     


Glu Tyr Ala Arg Gly Gly Pro Gly Gly Gly Gly Ser His His His His 
            260                 265                 270         


His His His His 
        275     


<210>  104
<211>  285
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Tagged humanized scFv

<400>  104

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Ala Ser Ala Ala Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
    130                 135                 140                 


Pro Gly Ser Ser Val Lys Val Ser Cys Lys Thr Ser Gly Gly Thr Phe 
145                 150                 155                 160 


Ser Ser Tyr Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
                165                 170                 175     


Glu Trp Met Gly Gly Ile Ile Pro Ile Phe Gly Lys Ala His Tyr Ala 
            180                 185                 190         


Gln Lys Phe Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Thr 
        195                 200                 205             


Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val 
    210                 215                 220                 


Tyr Tyr Cys Ala Arg Lys Tyr Asp Tyr Val Ser Gly Ser Pro Phe Gly 
225                 230                 235                 240 


Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ala 
                245                 250                 255     


Ala Lys Pro Leu Pro Glu Val Thr Asp Glu Tyr Ala Arg Gly Gly Pro 
            260                 265                 270         


Gly Gly Gly Gly Ser His His His His His His His His 
        275                 280                 285 


<210>  105
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized VH chain

<400>  105

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ile Met Met Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Tyr Pro Ser Gly Gly Ile Thr Phe Tyr Ala Asp Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ile Lys Leu Gly Thr Val Thr Thr Val Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  106
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized VL chain

<400>  106

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Asp Val Ser Asn Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Ser Ser 
                85                  90                  95      


Ser Thr Arg Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu 
            100                 105                 110 


<210>  107
<211>  276
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Tagged humanized scFv

<400>  107

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ile Met Met Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Tyr Pro Ser Gly Gly Ile Thr Phe Tyr Ala Asp Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ile Lys Leu Gly Thr Val Thr Thr Val Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gln Ser Ala Leu Thr Gln Pro Ala Ser 
    130                 135                 140                 


Val Ser Gly Ser Pro Gly Gln Ser Ile Thr Ile Ser Cys Thr Gly Thr 
145                 150                 155                 160 


Ser Ser Asp Val Gly Gly Tyr Asn Tyr Val Ser Trp Tyr Gln Gln His 
                165                 170                 175     


Pro Gly Lys Ala Pro Lys Leu Met Ile Tyr Asp Val Ser Asn Arg Pro 
            180                 185                 190         


Ser Gly Val Ser Asn Arg Phe Ser Gly Ser Lys Ser Gly Asn Thr Ala 
        195                 200                 205             


Ser Leu Thr Ile Ser Gly Leu Gln Ala Glu Asp Glu Ala Asp Tyr Tyr 
    210                 215                 220                 


Cys Ser Ser Tyr Thr Ser Ser Ser Thr Arg Val Phe Gly Thr Gly Thr 
225                 230                 235                 240 


Lys Val Thr Val Leu Ala Ala Ala Lys Pro Leu Pro Glu Val Thr Asp 
                245                 250                 255     


Glu Tyr Ala Arg Gly Gly Pro Gly Gly Gly Gly Ser His His His His 
            260                 265                 270         


His His His His 
        275     


<210>  108
<211>  287
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Tagged humanized scFv

<400>  108

Gly Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly 
1               5                   10                  15      


Gln Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly 
            20                  25                  30          


Tyr Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys 
        35                  40                  45              


Leu Met Ile Tyr Asp Val Ser Asn Arg Pro Ser Gly Val Ser Asn Arg 
    50                  55                  60                  


Phe Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly 
65                  70                  75                  80  


Leu Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Ser 
                85                  90                  95      


Ser Ser Thr Arg Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Ala Ser Ala Ala Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Leu Glu Ser Gly 
    130                 135                 140                 


Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala 
145                 150                 155                 160 


Ser Gly Phe Thr Phe Ser Ser Tyr Ile Met Met Trp Val Arg Gln Ala 
                165                 170                 175     


Pro Gly Lys Gly Leu Glu Trp Val Ser Ser Ile Tyr Pro Ser Gly Gly 
            180                 185                 190         


Ile Thr Phe Tyr Ala Asp Thr Val Lys Gly Arg Phe Thr Ile Ser Arg 
        195                 200                 205             


Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala 
    210                 215                 220                 


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ile Lys Leu Gly Thr Val 
225                 230                 235                 240 


Thr Thr Val Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                245                 250                 255     


Ala Ala Ala Lys Pro Leu Pro Glu Val Thr Asp Glu Tyr Ala Arg Gly 
            260                 265                 270         


Gly Pro Gly Gly Gly Gly Ser His His His His His His His His 
        275                 280                 285         


