                         SEQUENCE LISTING

<110>  BioNTech Cell & Gene Therapies GmbH
 
<120>  ANTIGEN-SPECIFIC T CELL RECEPTORS AND T CELL EPITOPES

<130>  674-308 PCT2

<150>  PCT/EP2020/057108
<151>  2020-03-16

<160>  112   

<170>  PatentIn version 3.5

<210>  1
<211>  180
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Gln Ala Glu Gly Arg Gly Thr Gly Gly Ser Thr Gly Asp Ala Asp 
1               5                   10                  15      


Gly Pro Gly Gly Pro Gly Ile Pro Asp Gly Pro Gly Gly Asn Ala Gly 
            20                  25                  30          


Gly Pro Gly Glu Ala Gly Ala Thr Gly Gly Arg Gly Pro Arg Gly Ala 
        35                  40                  45              


Gly Ala Ala Arg Ala Ser Gly Pro Gly Gly Gly Ala Pro Arg Gly Pro 
    50                  55                  60                  


His Gly Gly Ala Ala Ser Gly Leu Asn Gly Cys Cys Arg Cys Gly Ala 
65                  70                  75                  80  


Arg Gly Pro Glu Ser Arg Leu Leu Glu Phe Tyr Leu Ala Met Pro Phe 
                85                  90                  95      


Ala Thr Pro Met Glu Ala Glu Leu Ala Arg Arg Ser Leu Ala Gln Asp 
            100                 105                 110         


Ala Pro Pro Leu Pro Val Pro Gly Val Leu Leu Lys Glu Phe Thr Val 
        115                 120                 125             


Ser Gly Asn Ile Leu Thr Ile Arg Leu Thr Ala Ala Asp His Arg Gln 
    130                 135                 140                 


Leu Gln Leu Ser Ile Ser Ser Cys Leu Gln Gln Leu Ser Leu Leu Met 
145                 150                 155                 160 


Trp Ile Thr Gln Cys Phe Leu Pro Val Phe Leu Ala Gln Pro Pro Ser 
                165                 170                 175     


Gly Gln Arg Arg 
            180 


<210>  2
<211>  314
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Pro Leu Glu Gln Arg Ser Gln His Cys Lys Pro Glu Glu Gly Leu 
1               5                   10                  15      


Glu Ala Arg Gly Glu Ala Leu Gly Leu Val Gly Ala Gln Ala Pro Ala 
            20                  25                  30          


Thr Glu Glu Gln Glu Ala Ala Ser Ser Ser Ser Thr Leu Val Glu Val 
        35                  40                  45              


Thr Leu Gly Glu Val Pro Ala Ala Glu Ser Pro Asp Pro Pro Gln Ser 
    50                  55                  60                  


Pro Gln Gly Ala Ser Ser Leu Pro Thr Thr Met Asn Tyr Pro Leu Trp 
65                  70                  75                  80  


Ser Gln Ser Tyr Glu Asp Ser Ser Asn Gln Glu Glu Glu Gly Pro Ser 
                85                  90                  95      


Thr Phe Pro Asp Leu Glu Ser Glu Phe Gln Ala Ala Leu Ser Arg Lys 
            100                 105                 110         


Val Ala Glu Leu Val His Phe Leu Leu Leu Lys Tyr Arg Ala Arg Glu 
        115                 120                 125             


Pro Val Thr Lys Ala Glu Met Leu Gly Ser Val Val Gly Asn Trp Gln 
    130                 135                 140                 


Tyr Phe Phe Pro Val Ile Phe Ser Lys Ala Ser Ser Ser Leu Gln Leu 
145                 150                 155                 160 


Val Phe Gly Ile Glu Leu Met Glu Val Asp Pro Ile Gly His Leu Tyr 
                165                 170                 175     


Ile Phe Ala Thr Cys Leu Gly Leu Ser Tyr Asp Gly Leu Leu Gly Asp 
            180                 185                 190         


Asn Gln Ile Met Pro Lys Ala Gly Leu Leu Ile Ile Val Leu Ala Ile 
        195                 200                 205             


Ile Ala Arg Glu Gly Asp Cys Ala Pro Glu Glu Lys Ile Trp Glu Glu 
    210                 215                 220                 


Leu Ser Val Leu Glu Val Phe Glu Gly Arg Glu Asp Ser Ile Leu Gly 
225                 230                 235                 240 


Asp Pro Lys Lys Leu Leu Thr Gln His Phe Val Gln Glu Asn Tyr Leu 
                245                 250                 255     


Glu Tyr Arg Gln Val Pro Gly Ser Asp Pro Ala Cys Tyr Glu Phe Leu 
            260                 265                 270         


Trp Gly Pro Arg Ala Leu Val Glu Thr Ser Tyr Val Lys Val Leu His 
        275                 280                 285             


His Met Val Lys Ile Ser Gly Gly Pro His Ile Ser Tyr Pro Pro Leu 
    290                 295                 300                 


His Glu Trp Val Leu Arg Glu Gly Glu Glu 
305                 310                 


<210>  3
<211>  529
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Leu Leu Ala Val Leu Tyr Cys Leu Leu Trp Ser Phe Gln Thr Ser 
1               5                   10                  15      


Ala Gly His Phe Pro Arg Ala Cys Val Ser Ser Lys Asn Leu Met Glu 
            20                  25                  30          


Lys Glu Cys Cys Pro Pro Trp Ser Gly Asp Arg Ser Pro Cys Gly Gln 
        35                  40                  45              


Leu Ser Gly Arg Gly Ser Cys Gln Asn Ile Leu Leu Ser Asn Ala Pro 
    50                  55                  60                  


Leu Gly Pro Gln Phe Pro Phe Thr Gly Val Asp Asp Arg Glu Ser Trp 
65                  70                  75                  80  


Pro Ser Val Phe Tyr Asn Arg Thr Cys Gln Cys Ser Gly Asn Phe Met 
                85                  90                  95      


Gly Phe Asn Cys Gly Asn Cys Lys Phe Gly Phe Trp Gly Pro Asn Cys 
            100                 105                 110         


Thr Glu Arg Arg Leu Leu Val Arg Arg Asn Ile Phe Asp Leu Ser Ala 
        115                 120                 125             


Pro Glu Lys Asp Lys Phe Phe Ala Tyr Leu Thr Leu Ala Lys His Thr 
    130                 135                 140                 


Ile Ser Ser Asp Tyr Val Ile Pro Ile Gly Thr Tyr Gly Gln Met Lys 
145                 150                 155                 160 


Asn Gly Ser Thr Pro Met Phe Asn Asp Ile Asn Ile Tyr Asp Leu Phe 
                165                 170                 175     


Val Trp Met His Tyr Tyr Val Ser Met Asp Ala Leu Leu Gly Gly Ser 
            180                 185                 190         


Glu Ile Trp Arg Asp Ile Asp Phe Ala His Glu Ala Pro Ala Phe Leu 
        195                 200                 205             


Pro Trp His Arg Leu Phe Leu Leu Arg Trp Glu Gln Glu Ile Gln Lys 
    210                 215                 220                 


Leu Thr Gly Asp Glu Asn Phe Thr Ile Pro Tyr Trp Asp Trp Arg Asp 
225                 230                 235                 240 


Ala Glu Lys Cys Asp Ile Cys Thr Asp Glu Tyr Met Gly Gly Gln His 
                245                 250                 255     


Pro Thr Asn Pro Asn Leu Leu Ser Pro Ala Ser Phe Phe Ser Ser Trp 
            260                 265                 270         


Gln Ile Val Cys Ser Arg Leu Glu Glu Tyr Asn Ser His Gln Ser Leu 
        275                 280                 285             


Cys Asn Gly Thr Pro Glu Gly Pro Leu Arg Arg Asn Pro Gly Asn His 
    290                 295                 300                 


Asp Lys Ser Arg Thr Pro Arg Leu Pro Ser Ser Ala Asp Val Glu Phe 
305                 310                 315                 320 


Cys Leu Ser Leu Thr Gln Tyr Glu Ser Gly Ser Met Asp Lys Ala Ala 
                325                 330                 335     


Asn Phe Ser Phe Arg Asn Thr Leu Glu Gly Phe Ala Ser Pro Leu Thr 
            340                 345                 350         


Gly Ile Ala Asp Ala Ser Gln Ser Ser Met His Asn Ala Leu His Ile 
        355                 360                 365             


Tyr Met Asn Gly Thr Met Ser Gln Val Gln Gly Ser Ala Asn Asp Pro 
    370                 375                 380                 


Ile Phe Leu Leu His His Ala Phe Val Asp Ser Ile Phe Glu Gln Trp 
385                 390                 395                 400 


Leu Arg Arg His Arg Pro Leu Gln Glu Val Tyr Pro Glu Ala Asn Ala 
                405                 410                 415     


Pro Ile Gly His Asn Arg Glu Ser Tyr Met Val Pro Phe Ile Pro Leu 
            420                 425                 430         


Tyr Arg Asn Gly Asp Phe Phe Ile Ser Ser Lys Asp Leu Gly Tyr Asp 
        435                 440                 445             


Tyr Ser Tyr Leu Gln Asp Ser Asp Pro Asp Ser Phe Gln Asp Tyr Ile 
    450                 455                 460                 


Lys Ser Tyr Leu Glu Gln Ala Ser Arg Ile Trp Ser Trp Leu Leu Gly 
465                 470                 475                 480 


Ala Ala Met Val Gly Ala Val Leu Thr Ala Leu Leu Ala Gly Leu Val 
                485                 490                 495     


Ser Leu Leu Cys Arg His Lys Arg Lys Gln Leu Pro Glu Glu Lys Gln 
            500                 505                 510         


Pro Leu Leu Met Glu Lys Glu Asp Tyr His Ser Leu Tyr Gln Ser His 
        515                 520                 525             


Leu 
    


<210>  4
<211>  551
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Asn Glu Ser Pro Asp Pro Thr Asp Leu Ala Gly Val Ile Ile Glu 
1               5                   10                  15      


Leu Gly Pro Asn Asp Ser Pro Gln Thr Ser Glu Phe Lys Gly Ala Thr 
            20                  25                  30          


Glu Glu Ala Pro Ala Lys Glu Ser Pro His Thr Ser Glu Phe Lys Gly 
        35                  40                  45              


Ala Ala Arg Val Ser Pro Ile Ser Glu Ser Val Leu Ala Arg Leu Ser 
    50                  55                  60                  


Lys Phe Glu Val Glu Asp Ala Glu Asn Val Ala Ser Tyr Asp Ser Lys 
65                  70                  75                  80  


Ile Lys Lys Ile Val His Ser Ile Val Ser Ser Phe Ala Phe Gly Leu 
                85                  90                  95      


Phe Gly Val Phe Leu Val Leu Leu Asp Val Thr Leu Ile Leu Ala Asp 
            100                 105                 110         


Leu Ile Phe Thr Asp Ser Lys Leu Tyr Ile Pro Leu Glu Tyr Arg Ser 
        115                 120                 125             


Ile Ser Leu Ala Ile Ala Leu Phe Phe Leu Met Asp Val Leu Leu Arg 
    130                 135                 140                 


Val Phe Val Glu Arg Arg Gln Gln Tyr Phe Ser Asp Leu Phe Asn Ile 
145                 150                 155                 160 


Leu Asp Thr Ala Ile Ile Val Ile Leu Leu Leu Val Asp Val Val Tyr 
                165                 170                 175     


Ile Phe Phe Asp Ile Lys Leu Leu Arg Asn Ile Pro Arg Trp Thr His 
            180                 185                 190         


Leu Leu Arg Leu Leu Arg Leu Ile Ile Leu Leu Arg Ile Phe His Leu 
        195                 200                 205             


Phe His Gln Lys Arg Gln Leu Glu Lys Leu Ile Arg Arg Arg Val Ser 
    210                 215                 220                 


Glu Asn Lys Arg Arg Tyr Thr Arg Asp Gly Phe Asp Leu Asp Leu Thr 
225                 230                 235                 240 


Tyr Val Thr Glu Arg Ile Ile Ala Met Ser Phe Pro Ser Ser Gly Arg 
                245                 250                 255     


Gln Ser Phe Tyr Arg Asn Pro Ile Lys Glu Val Val Arg Phe Leu Asp 
            260                 265                 270         


Lys Lys His Arg Asn His Tyr Arg Val Tyr Asn Leu Cys Ser Glu Arg 
        275                 280                 285             


Ala Tyr Asp Pro Lys His Phe His Asn Arg Val Val Arg Ile Met Ile 
    290                 295                 300                 


Asp Asp His Asn Val Pro Thr Leu His Gln Met Val Val Phe Thr Lys 
305                 310                 315                 320 


Glu Val Asn Glu Trp Met Ala Gln Asp Leu Glu Asn Ile Val Ala Ile 
                325                 330                 335     


His Cys Lys Gly Gly Thr Asp Arg Thr Gly Thr Met Val Cys Ala Phe 
            340                 345                 350         


Leu Ile Ala Ser Glu Ile Cys Ser Thr Ala Lys Glu Ser Leu Tyr Tyr 
        355                 360                 365             


Phe Gly Glu Arg Arg Thr Asp Lys Thr His Ser Glu Lys Phe Gln Gly 
    370                 375                 380                 


Val Glu Thr Pro Ser Gln Lys Arg Tyr Val Ala Tyr Phe Ala Gln Val 
385                 390                 395                 400 


Lys His Leu Tyr Asn Trp Asn Leu Pro Pro Arg Arg Ile Leu Phe Ile 
                405                 410                 415     


Lys His Phe Ile Ile Tyr Ser Ile Pro Arg Tyr Val Arg Asp Leu Lys 
            420                 425                 430         


Ile Gln Ile Glu Met Glu Lys Lys Val Val Phe Ser Thr Ile Ser Leu 
        435                 440                 445             


Gly Lys Cys Ser Val Leu Asp Asn Ile Thr Thr Asp Lys Ile Leu Ile 
    450                 455                 460                 


Asp Val Phe Asp Gly Leu Pro Leu Tyr Asp Asp Val Lys Val Gln Phe 
465                 470                 475                 480 


Phe Tyr Ser Asn Leu Pro Thr Tyr Tyr Asp Asn Cys Ser Phe Tyr Phe 
                485                 490                 495     


Trp Leu His Thr Ser Phe Ile Glu Asn Asn Arg Leu Tyr Leu Pro Lys 
            500                 505                 510         


Asn Glu Leu Asp Asn Leu His Lys Gln Lys Ala Arg Arg Ile Tyr Pro 
        515                 520                 525             


Ser Asp Phe Ala Val Glu Ile Leu Phe Gly Glu Lys Met Thr Ser Ser 
    530                 535                 540                 


Asp Val Val Ala Gly Ser Asp 
545                 550     


<210>  5
<211>  143
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Glu Thr Leu Leu Gly Leu Leu Ile Leu Trp Leu Gln Leu Gln Trp 
1               5                   10                  15      


Val Ser Ser Lys Gln Glu Val Thr Gln Ile Pro Ala Ala Leu Ser Val 
            20                  25                  30          


Pro Glu Gly Glu Asn Leu Val Leu Asn Cys Ser Phe Thr Asp Ser Ala 
        35                  40                  45              


Ile Tyr Asn Leu Gln Trp Phe Arg Gln Asp Pro Gly Lys Gly Leu Thr 
    50                  55                  60                  


Ser Leu Leu Leu Ile Gln Ser Ser Gln Arg Glu Gln Thr Ser Gly Arg 
65                  70                  75                  80  


Leu Asn Ala Ser Leu Asp Lys Ser Ser Gly Arg Ser Thr Leu Tyr Ile 
                85                  90                  95      


Ala Ala Ser Gln Pro Gly Asp Ser Ala Thr Tyr Leu Cys Ala Pro Asn 
            100                 105                 110         


Asp Tyr Lys Leu Ser Phe Gly Ala Gly Thr Thr Val Thr Val Arg Ala 
        115                 120                 125             


Asn Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg Asp Ser 
    130                 135                 140             


<210>  6
<211>  146
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Gly Cys Arg Leu Leu Cys Trp Val Leu Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Gly Pro Val Lys Ala Gly Val Thr Gln Thr Pro Arg Tyr Leu Ile Lys 
            20                  25                  30          


Thr Arg Gly Gln Gln Val Thr Leu Ser Cys Ser Pro Ile Ser Gly His 
        35                  40                  45              


Arg Ser Val Ser Trp Tyr Gln Gln Thr Pro Gly Gln Gly Leu Gln Phe 
    50                  55                  60                  


Leu Phe Glu Tyr Phe Ser Glu Thr Gln Arg Asn Lys Gly Asn Phe Pro 
65                  70                  75                  80  


Gly Arg Phe Ser Gly Arg Gln Phe Ser Asn Ser Arg Ser Glu Met Asn 
                85                  90                  95      


Val Ser Thr Leu Glu Leu Gly Asp Ser Ala Leu Tyr Leu Cys Ala Ser 
            100                 105                 110         


Ser Phe Ser Ser Asp Asn Glu Gln Phe Phe Gly Pro Gly Thr Arg Leu 
        115                 120                 125             


Thr Val Leu Glu Asp Leu Lys Asn Val Phe Pro Pro Glu Val Ala Val 
    130                 135                 140                 


Phe Glu 
145     


<210>  7
<211>  145
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Glu Thr Leu Leu Gly Val Ser Leu Val Ile Leu Trp Leu Gln Leu 
1               5                   10                  15      


Ala Arg Val Asn Ser Gln Gln Gly Glu Glu Asp Pro Gln Ala Leu Ser 
            20                  25                  30          


Ile Gln Glu Gly Glu Asn Ala Thr Met Asn Cys Ser Tyr Lys Thr Ser 
        35                  40                  45              


Ile Asn Asn Leu Gln Trp Tyr Arg Gln Asn Ser Gly Arg Gly Leu Val 
    50                  55                  60                  


His Leu Ile Leu Ile Arg Ser Asn Glu Arg Glu Lys His Ser Gly Arg 
65                  70                  75                  80  


Leu Arg Val Thr Leu Asp Thr Ser Lys Lys Ser Ser Ser Leu Leu Ile 
                85                  90                  95      


Thr Ala Ser Arg Ala Ala Asp Thr Ala Ser Tyr Phe Cys Ala Thr Asp 
            100                 105                 110         


Ser Asn Asp Tyr Lys Leu Ser Phe Gly Ala Gly Thr Thr Val Thr Val 
        115                 120                 125             


Arg Ala Asn Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg Asp 
    130                 135                 140                 


Ser 
145 


<210>  8
<211>  145
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Asp Ile Trp Leu Leu Cys Trp Val Val Leu Gly Phe Leu Gly Thr 
1               5                   10                  15      


Asp His Thr Gly Ala Gly Val Ser Gln Ser Pro Arg Tyr Lys Val Thr 
            20                  25                  30          


Lys Arg Gly Gln Asp Val Ala Leu Arg Cys Asp Pro Ile Ser Gly His 
        35                  40                  45              


Val Ser Leu Tyr Trp Tyr Arg Gln Ala Leu Gly Gln Gly Pro Glu Phe 
    50                  55                  60                  


Leu Thr Tyr Phe Asn Tyr Glu Ala Gln Gln Asp Lys Ser Gly Leu Pro 
65                  70                  75                  80  


Asn Asp Arg Phe Ser Ala Glu Arg Pro Glu Gly Ser Ile Ser Thr Leu 
                85                  90                  95      


Thr Ile Gln Arg Thr Glu Gln Arg Asp Ser Ala Met Tyr Arg Cys Ala 
            100                 105                 110         


Ser Ser Trp Gly Gly Glu Leu Phe Phe Gly Glu Gly Ser Arg Leu Thr 
        115                 120                 125             


Val Leu Glu Asp Leu Lys Asn Val Phe Pro Pro Glu Val Ala Val Phe 
    130                 135                 140                 


Glu 
145 


<210>  9
<211>  153
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Ala Cys Pro Gly Phe Leu Trp Ala Leu Val Ile Ser Thr Cys Leu 
1               5                   10                  15      


Glu Phe Ser Met Ala Gln Thr Val Thr Gln Ser Gln Pro Glu Met Ser 
            20                  25                  30          


Val Gln Glu Ala Glu Thr Val Thr Leu Ser Cys Thr Tyr Asp Thr Ser 
        35                  40                  45              


Glu Ser Asp Tyr Tyr Leu Phe Trp Tyr Lys Gln Pro Pro Ser Arg Gln 
    50                  55                  60                  


Met Ile Leu Val Ile Arg Gln Glu Ala Tyr Lys Gln Gln Asn Ala Thr 
65                  70                  75                  80  


Glu Asn Arg Phe Ser Val Asn Phe Gln Lys Ala Ala Lys Ser Phe Ser 
                85                  90                  95      


Leu Lys Ile Ser Asp Ser Gln Leu Gly Asp Ala Ala Met Tyr Phe Cys 
            100                 105                 110         


Ala Tyr Arg Ser Asp Ala Gly Gly Thr Ser Tyr Gly Lys Leu Thr Phe 
        115                 120                 125             


Gly Gln Gly Thr Ile Leu Thr Val His Pro Asn Ile Gln Asn Pro Asp 
    130                 135                 140                 


Pro Ala Val Tyr Gln Leu Arg Asp Ser 
145                 150             


<210>  10
<211>  149
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Ser Ile Gly Leu Leu Cys Trp Val Leu Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Gly Ser Val Glu Thr Gly Val Thr Gln Ser Pro Thr His Leu Ile Lys 
            20                  25                  30          


Thr Arg Gly Gln Gln Val Thr Leu Arg Cys Ser Ser Gln Ser Gly His 
        35                  40                  45              


Asn Thr Val Ser Trp Tyr Gln Gln Ala Leu Gly Gln Gly Pro Gln Phe 
    50                  55                  60                  


Ile Phe Gln Tyr Tyr Arg Glu Glu Glu Asn Gly Arg Gly Asn Phe Pro 
65                  70                  75                  80  


Pro Arg Phe Ser Gly Leu Gln Phe Pro Asn Tyr Ser Ser Glu Leu Asn 
                85                  90                  95      


Val Asn Ala Leu Glu Leu Asp Asp Ser Ala Leu Tyr Leu Cys Ala Ser 
            100                 105                 110         


Ser Pro Arg Thr Gly Gly Ala Gly Asn Thr Ile Tyr Phe Gly Glu Gly 
        115                 120                 125             


Ser Trp Leu Thr Val Val Glu Asp Leu Asn Lys Val Phe Pro Pro Glu 
    130                 135                 140                 


Val Ala Val Phe Glu 
145                 


<210>  11
<211>  151
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Ala Ser Ala Pro Ile Ser Met Leu Ala Met Leu Phe Thr Leu Ser 
1               5                   10                  15      


Gly Leu Arg Ala Gln Ser Val Ala Gln Pro Glu Asp Gln Val Asn Val 
            20                  25                  30          


Ala Glu Gly Asn Pro Leu Thr Val Lys Cys Thr Tyr Ser Val Ser Gly 
        35                  40                  45              


Asn Pro Tyr Leu Phe Trp Tyr Val Gln Tyr Pro Asn Arg Gly Leu Gln 
    50                  55                  60                  


Phe Leu Leu Lys Tyr Ile Thr Gly Asp Asn Leu Val Lys Gly Ser Tyr 
65                  70                  75                  80  


Gly Phe Glu Ala Glu Phe Asn Lys Ser Gln Thr Ser Phe His Leu Lys 
                85                  90                  95      


Lys Pro Ser Ala Leu Val Ser Asp Ser Ala Leu Tyr Phe Cys Ala Val 
            100                 105                 110         


Arg Asp Ile Glu Val Val Asn Ala Gly Asn Met Leu Thr Phe Gly Gly 
        115                 120                 125             


Gly Thr Arg Leu Met Val Lys Pro His Ile Gln Asn Pro Asp Pro Ala 
    130                 135                 140                 


Val Tyr Gln Leu Arg Asp Ser 
145                 150     


<210>  12
<211>  146
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Asp Ile Trp Leu Val Cys Trp Val Leu Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Gly Ser Val Glu Thr Gly Val Thr Gln Ser Pro Thr His Leu Ile Lys 
            20                  25                  30          


Thr Arg Gly Gln Gln Val Thr Leu Arg Cys Ser Ser Gln Ser Gly His 
        35                  40                  45              


Asn Thr Val Ser Trp Tyr Gln Gln Ala Leu Gly Gln Gly Pro Gln Phe 
    50                  55                  60                  


Ile Phe Gln Tyr Tyr Arg Glu Glu Glu Asn Gly Arg Gly Asn Phe Pro 
65                  70                  75                  80  


Pro Arg Phe Ser Gly Leu Gln Phe Pro Asn Tyr Ser Ser Glu Leu Asn 
                85                  90                  95      


Val Asn Ala Leu Glu Leu Asp Asp Ser Ala Leu Tyr Leu Cys Ala Ser 
            100                 105                 110         


Thr Asp Arg Val Arg Tyr Glu Gln Phe Phe Gly Pro Gly Thr Arg Leu 
        115                 120                 125             


Thr Val Leu Glu Asp Leu Lys Asn Val Phe Pro Pro Glu Val Ala Val 
    130                 135                 140                 


Phe Glu 
145     


<210>  13
<211>  150
<212>  PRT
<213>  Homo sapiens

<400>  13

Met Glu Lys Asn Pro Leu Ala Ala Pro Leu Leu Ile Leu Trp Phe His 
1               5                   10                  15      


Leu Asp Cys Val Ser Ser Ile Leu Asn Val Glu Gln Ser Pro Gln Ser 
            20                  25                  30          


Leu His Val Gln Glu Gly Asp Ser Thr Asn Phe Thr Cys Ser Phe Pro 
        35                  40                  45              


Ser Ser Asn Phe Tyr Ala Leu His Trp Tyr Arg Trp Glu Thr Ala Lys 
    50                  55                  60                  


Ser Pro Glu Ala Leu Phe Val Met Thr Leu Asn Gly Asp Glu Lys Lys 
65                  70                  75                  80  


Lys Gly Arg Ile Ser Ala Thr Leu Asn Thr Lys Glu Gly Tyr Ser Tyr 
                85                  90                  95      


Leu Tyr Ile Lys Gly Ser Gln Pro Glu Asp Ser Ala Thr Tyr Leu Cys 
            100                 105                 110         


Ala Phe Leu Gly Ser Gly Asn Thr Gly Lys Leu Ile Phe Gly Gln Gly 
        115                 120                 125             


Thr Thr Leu Gln Val Lys Pro Asp Ile Gln Asn Pro Asp Pro Ala Val 
    130                 135                 140                 


Tyr Gln Leu Arg Asp Ser 
145                 150 


<210>  14
<211>  146
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Leu Leu Leu Leu Leu Leu Leu Gly Pro Gly Ser Gly Leu Gly Ala 
1               5                   10                  15      


Val Val Ser Gln His Pro Ser Trp Val Ile Cys Lys Ser Gly Thr Ser 
            20                  25                  30          


Val Lys Ile Glu Cys Arg Ser Leu Asp Phe Gln Ala Thr Thr Met Phe 
        35                  40                  45              


Trp Tyr Arg Gln Phe Pro Lys Gln Ser Leu Met Leu Met Ala Thr Ser 
    50                  55                  60                  


Asn Glu Gly Ser Lys Ala Thr Tyr Glu Gln Gly Val Glu Lys Asp Lys 
65                  70                  75                  80  


Phe Leu Ile Asn His Ala Ser Leu Thr Leu Ser Thr Leu Thr Val Thr 
                85                  90                  95      


Ser Ala His Pro Glu Asp Ser Ser Phe Tyr Ile Cys Ser Ala Ile Arg 
            100                 105                 110         


Pro Ser Gly Gly Ala Phe Glu Gln Tyr Phe Gly Pro Gly Thr Arg Leu 
        115                 120                 125             


Thr Val Thr Glu Asp Leu Lys Asn Val Phe Pro Pro Glu Val Ala Val 
    130                 135                 140                 


Phe Glu 
145     


<210>  15
<211>  147
<212>  PRT
<213>  Homo sapiens

<400>  15

Met Thr Ser Ile Arg Ala Val Phe Ile Phe Leu Trp Leu Gln Leu Asp 
1               5                   10                  15      


Leu Val Asn Gly Glu Asn Val Glu Gln His Pro Ser Thr Leu Ser Val 
            20                  25                  30          


Gln Glu Gly Asp Ser Ala Val Ile Lys Cys Thr Tyr Ser Asp Ser Ala 
        35                  40                  45              


Ser Asn Tyr Phe Pro Trp Tyr Lys Gln Glu Leu Gly Lys Gly Pro Gln 
    50                  55                  60                  


Leu Ile Ile Asp Ile Arg Ser Asn Val Gly Glu Lys Lys Asp Gln Arg 
65                  70                  75                  80  


Ile Ala Val Thr Leu Asn Lys Thr Ala Lys His Phe Ser Leu His Ile 
                85                  90                  95      


Thr Glu Thr Gln Pro Glu Asp Ser Ala Val Tyr Phe Cys Ala Ala Arg 
            100                 105                 110         


Ala Thr Ser Gly Thr Tyr Lys Tyr Ile Phe Gly Thr Gly Thr Arg Leu 
        115                 120                 125             


Lys Val Leu Ala Asn Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu 
    130                 135                 140                 


Arg Asp Ser 
145         


<210>  16
<211>  145
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Leu Leu Leu Leu Leu Leu Leu Gly Pro Gly Ser Gly Leu Gly Ala 
1               5                   10                  15      


Val Val Ser Gln His Pro Ser Arg Val Ile Cys Lys Ser Gly Thr Ser 
            20                  25                  30          


Val Lys Ile Glu Cys Arg Ser Leu Asp Phe Gln Ala Thr Thr Met Phe 
        35                  40                  45              


Trp Tyr Arg Gln Phe Pro Lys Lys Ser Leu Met Leu Met Ala Thr Ser 
    50                  55                  60                  


Asn Glu Gly Ser Lys Ala Thr Tyr Glu Gln Gly Val Glu Lys Asp Lys 
65                  70                  75                  80  


Phe Leu Ile Asn His Ala Ser Leu Thr Leu Ser Thr Leu Thr Val Thr 
                85                  90                  95      


Ser Ala His Pro Glu Asp Ser Ser Phe Tyr Ile Cys Ser Ala Ser Phe 
            100                 105                 110         


Ser Arg Asp Ile Glu Thr Gln Tyr Phe Gly Pro Gly Thr Arg Leu Leu 
        115                 120                 125             


Val Leu Glu Asp Leu Lys Asn Val Phe Pro Pro Glu Val Ala Val Phe 
    130                 135                 140                 


Glu 
145 


<210>  17
<211>  143
<212>  PRT
<213>  Homo sapiens

<400>  17

Met Trp Gly Ala Phe Leu Leu Tyr Val Ser Met Lys Met Gly Gly Thr 
1               5                   10                  15      


Thr Gly Gln Asn Ile Asp Gln Pro Thr Glu Met Thr Ala Thr Glu Gly 
            20                  25                  30          


Ala Ile Val Gln Ile Asn Cys Thr Tyr Gln Thr Ser Gly Phe Asn Gly 
        35                  40                  45              


Leu Phe Trp Tyr Gln Gln His Ala Gly Glu Ala Pro Thr Phe Leu Ser 
    50                  55                  60                  


Tyr Asn Val Leu Asp Gly Leu Glu Glu Lys Gly Arg Phe Ser Ser Phe 
65                  70                  75                  80  


Leu Ser Arg Ser Lys Gly Tyr Ser Tyr Leu Leu Leu Lys Glu Leu Gln 
                85                  90                  95      


Met Lys Asp Ser Ala Ser Tyr Leu Cys Ala Val Arg Leu Gly Asp Ala 
            100                 105                 110         


Gly Asn Met Leu Thr Phe Gly Gly Gly Thr Arg Leu Met Val Lys Pro 
        115                 120                 125             


His Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg Asp Ser 
    130                 135                 140             


<210>  18
<211>  148
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Gly Thr Arg Leu Leu Cys Cys Val Ala Phe Cys Leu Leu Gly Ala 
1               5                   10                  15      


Gly Pro Val Asp Ser Gly Val Thr Gln Thr Pro Lys His Leu Ile Thr 
            20                  25                  30          


Ala Thr Gly Gln Arg Val Thr Leu Arg Cys Ser Pro Arg Ser Gly Asp 
        35                  40                  45              


Leu Ser Val Tyr Trp Tyr Gln Gln Ser Leu Asp Gln Gly Leu Gln Phe 
    50                  55                  60                  


Leu Ile Gln Tyr Tyr Asn Gly Glu Glu Arg Ala Lys Gly Asn Ile Leu 
65                  70                  75                  80  


Glu Arg Phe Ser Ala Gln Gln Phe Pro Asp Leu His Ser Glu Leu Asn 
                85                  90                  95      


Leu Ser Ser Leu Glu Leu Gly Asp Ser Ala Leu Tyr Phe Cys Ala Ser 
            100                 105                 110         


Ser Val Gly Arg Gly Met Asn Thr Glu Ala Phe Phe Gly Gln Gly Thr 
        115                 120                 125             


Arg Leu Thr Val Val Glu Asp Leu Asn Lys Val Phe Pro Pro Glu Val 
    130                 135                 140                 


Ala Val Phe Glu 
145             


<210>  19
<211>  142
<212>  PRT
<213>  Homo sapiens

<400>  19

Met Leu Leu Ile Thr Ser Met Leu Val Leu Trp Met Gln Leu Ser Gln 
1               5                   10                  15      


Val Asn Gly Gln Gln Val Met Gln Ile Pro Gln Tyr Gln His Val Gln 
            20                  25                  30          


Glu Gly Glu Asp Phe Thr Thr Tyr Cys Asn Ser Ser Thr Thr Leu Ser 
        35                  40                  45              


Asn Ile Gln Trp Tyr Lys Gln Arg Pro Gly Gly His Pro Val Phe Leu 
    50                  55                  60                  


Ile Gln Leu Val Lys Ser Gly Glu Val Lys Lys Gln Lys Arg Leu Thr 
65                  70                  75                  80  


Phe Gln Phe Gly Glu Ala Lys Lys Asn Ser Ser Leu His Ile Thr Ala 
                85                  90                  95      


Thr Gln Thr Thr Asp Val Gly Thr Tyr Phe Cys Ala Asp Asn Ala Gly 
            100                 105                 110         


Asn Met Leu Thr Phe Gly Gly Gly Thr Arg Leu Met Val Lys Pro His 
        115                 120                 125             


Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg Asp Ser 
    130                 135                 140         


<210>  20
<211>  146
<212>  PRT
<213>  Homo sapiens

<400>  20

Met Leu Leu Leu Leu Leu Leu Leu Gly Pro Ala Gly Ser Gly Leu Gly 
1               5                   10                  15      


Ala Val Val Ser Gln His Pro Ser Trp Val Ile Cys Lys Ser Gly Thr 
            20                  25                  30          


Ser Val Lys Ile Glu Cys Arg Ser Leu Asp Phe Gln Ala Thr Thr Met 
        35                  40                  45              


Phe Trp Tyr Arg Gln Phe Pro Lys Gln Ser Leu Met Leu Met Ala Thr 
    50                  55                  60                  


Ser Asn Glu Gly Ser Lys Ala Thr Tyr Glu Gln Gly Val Glu Lys Asp 
65                  70                  75                  80  


Lys Phe Leu Ile Asn His Ala Ser Leu Thr Leu Ser Thr Leu Thr Val 
                85                  90                  95      


Thr Ser Ala His Pro Glu Asp Ser Ser Phe Tyr Ile Cys Ser Ala Arg 
            100                 105                 110         


Asp Pro Gly Arg Asn Tyr Gly Tyr Thr Phe Gly Ser Gly Thr Arg Leu 
        115                 120                 125             


Thr Val Val Glu Asp Leu Asn Lys Val Phe Pro Pro Glu Val Ala Val 
    130                 135                 140                 


Phe Glu 
145     


<210>  21
<211>  142
<212>  PRT
<213>  Homo sapiens

<400>  21

Met Leu Leu Ile Thr Ser Met Leu Val Leu Trp Met Gln Leu Ser Gln 
1               5                   10                  15      


Val Asn Gly Gln Gln Val Met Gln Ile Pro Gln Tyr Gln His Val Gln 
            20                  25                  30          


Glu Gly Glu Asp Phe Thr Thr Tyr Cys Asn Ser Ser Thr Thr Leu Ser 
        35                  40                  45              


Asn Ile Gln Trp Tyr Lys Gln Arg Pro Gly Gly His Pro Val Phe Leu 
    50                  55                  60                  


Ile Gln Leu Val Lys Ser Gly Glu Val Lys Lys Gln Lys Arg Leu Thr 
65                  70                  75                  80  


Phe Gln Phe Gly Glu Ala Lys Lys Asn Ser Ser Leu His Ile Thr Ala 
                85                  90                  95      


Thr Gln Thr Thr Asp Val Gly Thr Tyr Phe Cys Gly Asp Asn Ala Gly 
            100                 105                 110         


Asn Met Leu Thr Phe Gly Gly Gly Thr Arg Leu Met Val Lys Pro His 
        115                 120                 125             


Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg Asp Ser 
    130                 135                 140         


<210>  22
<211>  145
<212>  PRT
<213>  Homo sapiens

<400>  22

Met Leu Leu Leu Leu Leu Leu Leu Gly Pro Gly Ser Gly Leu Gly Ala 
1               5                   10                  15      


Val Val Ser Gln His Pro Ser Trp Val Ile Cys Lys Ser Gly Thr Ser 
            20                  25                  30          


Val Lys Ile Glu Cys Arg Ser Leu Asp Phe Gln Ala Thr Thr Met Phe 
        35                  40                  45              


Trp Tyr Arg Gln Phe Pro Lys Gln Ser Leu Met Leu Met Ala Thr Ser 
    50                  55                  60                  


Asn Glu Gly Ser Lys Ala Thr Tyr Glu Gln Gly Val Glu Lys Asp Lys 
65                  70                  75                  80  


Phe Leu Ile Asn His Ala Ser Leu Thr Leu Ser Thr Leu Thr Val Thr 
                85                  90                  95      


Ser Ala His Pro Glu Asp Ser Ser Phe Tyr Ile Cys Ser Ala Arg Asp 
            100                 105                 110         


Glu Asp Arg Pro Tyr Gly Tyr Thr Phe Gly Ser Gly Thr Arg Leu Thr 
        115                 120                 125             


Val Val Glu Asp Leu Asn Lys Val Phe Pro Pro Glu Val Ala Val Phe 
    130                 135                 140                 


Glu 
145 


<210>  23
<211>  148
<212>  PRT
<213>  Homo sapiens

<400>  23

Met Leu Leu Leu Leu Val Pro Val Leu Glu Val Ile Phe Thr Leu Gly 
1               5                   10                  15      


Gly Thr Arg Ala Gln Ser Val Thr Gln Leu Gly Ser His Val Ser Val 
            20                  25                  30          


Ser Glu Gly Ala Leu Val Leu Leu Arg Cys Asn Tyr Ser Ser Ser Val 
        35                  40                  45              


Pro Pro Tyr Leu Phe Trp Tyr Val Gln Tyr Pro Asn Gln Gly Leu Gln 
    50                  55                  60                  


Leu Leu Leu Lys Tyr Thr Ser Ala Ala Thr Leu Val Lys Gly Ile Asn 
65                  70                  75                  80  


Gly Phe Glu Ala Glu Phe Lys Lys Ser Glu Thr Ser Phe His Leu Thr 
                85                  90                  95      


Lys Pro Ser Ala His Met Ser Asp Ala Ala Glu Tyr Phe Cys Ala Val 
            100                 105                 110         


Ser Asp Gly Gly Ala Thr Asn Lys Leu Ile Phe Gly Thr Gly Thr Leu 
        115                 120                 125             


Leu Ala Val Gln Pro Asn Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln 
    130                 135                 140                 


Leu Arg Asp Ser 
145             


<210>  24
<211>  148
<212>  PRT
<213>  Homo sapiens

<400>  24

Met Gly Thr Arg Leu Leu Cys Cys Val Val Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Asn Thr Val Asp Gly Gly Ile Thr Gln Ser Pro Lys Tyr Leu Phe Arg 
            20                  25                  30          


Lys Glu Gly Gln Asn Val Thr Leu Ser Cys Glu Gln Asn Leu Asn His 
        35                  40                  45              


Asp Ala Met Tyr Trp Tyr Arg Gln Asp Pro Gly Gln Gly Leu Arg Leu 
    50                  55                  60                  


Ile Tyr Tyr Ser Gln Ile Val Asn Asp Phe Gln Lys Gly Asp Ile Ala 
65                  70                  75                  80  


Glu Gly Tyr Ser Val Ser Arg Glu Lys Lys Glu Ser Phe Pro Leu Thr 
                85                  90                  95      


Val Thr Ser Ala Gln Lys Asn Pro Thr Ala Phe Tyr Leu Cys Ala Ser 
            100                 105                 110         


Ser Ser Gly Gly Arg Ala Ser Phe Thr Gln Tyr Phe Gly Pro Gly Thr 
        115                 120                 125             


Arg Leu Thr Val Leu Glu Asp Leu Lys Asn Val Phe Pro Pro Glu Val 
    130                 135                 140                 


Ala Val Phe Glu 
145             


<210>  25
<211>  148
<212>  PRT
<213>  Homo sapiens

<400>  25

Met Asn Tyr Ser Pro Gly Leu Val Ser Leu Ile Leu Leu Leu Leu Gly 
1               5                   10                  15      


Arg Thr Arg Gly Asn Ser Val Thr Gln Met Glu Gly Pro Val Thr Leu 
            20                  25                  30          


Ser Glu Glu Ala Phe Leu Thr Ile Asn Cys Thr Tyr Thr Ala Thr Gly 
        35                  40                  45              


Tyr Pro Ser Leu Phe Trp Tyr Val Gln Tyr Pro Gly Glu Gly Leu Gln 
    50                  55                  60                  


Leu Leu Leu Lys Ala Thr Lys Ala Asp Asp Lys Gly Ser Asn Lys Gly 
65                  70                  75                  80  


Phe Glu Ala Thr Tyr Arg Lys Glu Thr Thr Ser Phe His Leu Glu Lys 
                85                  90                  95      


Gly Ser Val Gln Val Ser Asp Ser Ala Val Tyr Phe Cys Ala Leu Ser 
            100                 105                 110         


Asp Pro Asn Asn Gln Gly Gly Lys Leu Ile Phe Gly Gln Gly Thr Glu 
        115                 120                 125             


Leu Ser Val Lys Pro Asn Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln 
    130                 135                 140                 


Leu Arg Asp Ser 
145             


<210>  26
<211>  147
<212>  PRT
<213>  Homo sapiens

<400>  26

Met Gly Thr Arg Leu Leu Cys Cys Val Val Phe Cys Leu Leu Gln Ala 
1               5                   10                  15      


Gly Pro Leu Asp Thr Ala Val Ser Gln Thr Pro Lys Tyr Leu Val Thr 
            20                  25                  30          


Gln Met Gly Asn Asp Lys Ser Ile Lys Cys Glu Gln Asn Leu Gly His 
        35                  40                  45              


Asp Thr Met Tyr Trp Tyr Lys Gln Asp Ser Lys Lys Phe Leu Lys Ile 
    50                  55                  60                  


Met Phe Ser Tyr Asn Asn Lys Glu Leu Ile Ile Asn Glu Thr Val Pro 
65                  70                  75                  80  


Asn Arg Phe Ser Pro Lys Ser Pro Asp Lys Ala His Leu Asn Leu His 
                85                  90                  95      


Ile Asn Ser Leu Glu Leu Gly Asp Ser Ala Val Tyr Phe Cys Ala Ser 
            100                 105                 110         


Ser Gln Val Arg Gly Thr Thr Glu Ala Phe Phe Gly Gln Gly Thr Arg 
        115                 120                 125             


Leu Thr Val Val Glu Asp Leu Asn Lys Val Phe Pro Pro Glu Val Ala 
    130                 135                 140                 


Val Phe Glu 
145         


<210>  27
<211>  142
<212>  PRT
<213>  Homo sapiens

<400>  27

Met Lys Lys Leu Leu Ala Met Ile Leu Trp Leu Gln Leu Asp Arg Leu 
1               5                   10                  15      


Ser Gly Glu Leu Lys Val Glu Gln Asn Pro Leu Phe Leu Ser Met Gln 
            20                  25                  30          


Glu Gly Lys Asn Tyr Thr Ile Tyr Cys Asn Tyr Ser Thr Thr Ser Asp 
        35                  40                  45              


Arg Leu Tyr Trp Tyr Arg Gln Asp Pro Gly Lys Ser Leu Glu Ser Leu 
    50                  55                  60                  


Phe Val Leu Leu Ser Asn Gly Ala Val Lys Gln Glu Gly Arg Leu Met 
65                  70                  75                  80  


Ala Ser Leu Asp Thr Lys Ala Arg Leu Ser Thr Leu His Ile Thr Ala 
                85                  90                  95      


Ala Val His Asp Leu Ser Ala Thr Tyr Phe Cys Ala Glu Pro Asn Thr 
            100                 105                 110         


Asp Lys Leu Ile Phe Gly Thr Gly Thr Arg Leu Gln Val Phe Pro Asn 
        115                 120                 125             


Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg Asp Ser 
    130                 135                 140         


<210>  28
<211>  146
<212>  PRT
<213>  Homo sapiens

<400>  28

Met Gly Pro Gly Leu Leu His Trp Met Ala Leu Cys Leu Leu Gly Thr 
1               5                   10                  15      


Gly His Gly Asp Ala Met Val Ile Gln Asn Pro Arg Tyr Gln Val Thr 
            20                  25                  30          


Gln Phe Gly Lys Pro Val Thr Leu Ser Cys Ser Gln Thr Leu Asn His 
        35                  40                  45              


Asn Val Met Tyr Trp Tyr Gln Gln Lys Ser Ser Gln Ala Pro Lys Leu 
    50                  55                  60                  


Leu Phe His Tyr Tyr Asp Lys Asp Phe Asn Asn Glu Ala Asp Thr Pro 
65                  70                  75                  80  


Asp Asn Phe Gln Ser Arg Arg Pro Asn Thr Ser Phe Cys Phe Leu Asp 
                85                  90                  95      


Ile Arg Ser Pro Gly Leu Gly Asp Thr Ala Met Tyr Leu Cys Ala Thr 
            100                 105                 110         


Asn Tyr Asp Arg Gly Tyr Glu Gln Tyr Phe Gly Pro Gly Thr Arg Leu 
        115                 120                 125             


Thr Val Thr Glu Asp Leu Lys Asn Val Phe Pro Pro Glu Val Ala Val 
    130                 135                 140                 


Phe Glu 
145     


<210>  29
<211>  146
<212>  PRT
<213>  Homo sapiens

<400>  29

Met Lys Ser Leu Arg Val Leu Leu Val Ile Leu Trp Leu Gln Leu Ser 
1               5                   10                  15      


Trp Val Trp Ser Gln Gln Lys Glu Val Glu Gln Asn Ser Gly Pro Leu 
            20                  25                  30          


Ser Val Pro Glu Gly Ala Ile Ala Ser Leu Asn Cys Thr Tyr Ser Asp 
        35                  40                  45              


Arg Gly Ser Gln Ser Phe Phe Trp Tyr Arg Gln Tyr Ser Gly Lys Ser 
    50                  55                  60                  


Pro Glu Leu Ile Met Phe Ile Tyr Ser Asn Gly Asp Lys Glu Asp Gly 
65                  70                  75                  80  


Arg Phe Thr Ala Gln Leu Asn Lys Ala Ser Gln Tyr Val Ser Leu Leu 
                85                  90                  95      


Ile Arg Asp Ser Gln Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala Val 
            100                 105                 110         


Trp Ala Thr Gly Asn Gln Phe Tyr Phe Gly Thr Gly Thr Ser Leu Thr 
        115                 120                 125             


Val Ile Pro Asn Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg 
    130                 135                 140                 


Asp Ser 
145     


<210>  30
<211>  146
<212>  PRT
<213>  Homo sapiens

<400>  30

Met Gly Pro Gly Leu Leu His Trp Met Ala Leu Cys Leu Leu Gly Thr 
1               5                   10                  15      


Gly His Gly Asp Ala Met Val Ile Gln Asn Pro Arg Tyr Gln Val Thr 
            20                  25                  30          


Gln Phe Gly Lys Pro Val Thr Leu Ser Cys Ser Gln Thr Leu Asn His 
        35                  40                  45              


Asn Val Met Tyr Trp Tyr Gln Gln Lys Ser Ser Gln Ala Pro Lys Leu 
    50                  55                  60                  


Leu Phe His Tyr Tyr Asp Lys Asp Phe Asn Asn Glu Ala Asp Thr Pro 
65                  70                  75                  80  


Asp Asn Phe Gln Ser Arg Arg Pro Asn Thr Ser Phe Cys Phe Leu Asp 
                85                  90                  95      


Ile Arg Ser Pro Gly Leu Gly Asp Thr Ala Met Tyr Leu Cys Ala Thr 
            100                 105                 110         


Ser Phe Asp Arg Gly Tyr Glu Gln Tyr Phe Gly Pro Gly Thr Arg Leu 
        115                 120                 125             


Thr Val Thr Glu Asp Leu Lys Asn Val Phe Pro Pro Glu Val Ala Val 
    130                 135                 140                 


Phe Glu 
145     


<210>  31
<211>  147
<212>  PRT
<213>  Homo sapiens

<400>  31

Met Ile Ser Leu Arg Val Leu Leu Val Ile Leu Trp Leu Gln Leu Ser 
1               5                   10                  15      


Trp Val Trp Ser Gln Arg Lys Glu Val Glu Gln Asp Pro Gly Pro Phe 
            20                  25                  30          


Asn Val Pro Glu Gly Ala Thr Val Ala Phe Asn Cys Thr Tyr Ser Asn 
        35                  40                  45              


Ser Ala Ser Gln Ser Phe Phe Trp Tyr Arg Gln Asp Cys Arg Lys Glu 
    50                  55                  60                  


Pro Lys Leu Leu Met Ser Val Tyr Ser Ser Gly Asn Glu Asp Gly Arg 
65                  70                  75                  80  


Phe Thr Ala Gln Leu Asn Arg Ala Ser Gln Tyr Ile Ser Leu Leu Ile 
                85                  90                  95      


Arg Asp Ser Lys Leu Ser Asp Ser Ala Thr Tyr Leu Cys Val Val Asn 
            100                 105                 110         


Glu Arg Asn Ser Gly Tyr Ala Leu Asn Phe Gly Lys Gly Thr Ser Leu 
        115                 120                 125             


Leu Val Thr Pro His Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu 
    130                 135                 140                 


Arg Asp Ser 
145         


<210>  32
<211>  147
<212>  PRT
<213>  Homo sapiens

<400>  32

Met Ala Ser Leu Leu Phe Phe Cys Gly Ala Phe Tyr Leu Leu Gly Thr 
1               5                   10                  15      


Gly Ser Met Asp Ala Asp Val Thr Gln Thr Pro Arg Asn Arg Ile Thr 
            20                  25                  30          


Lys Thr Gly Lys Arg Ile Met Leu Glu Cys Ser Gln Thr Lys Gly His 
        35                  40                  45              


Asp Arg Met Tyr Trp Tyr Arg Gln Asp Pro Gly Leu Gly Leu Arg Leu 
    50                  55                  60                  


Ile Tyr Tyr Ser Phe Asp Val Lys Asp Ile Asn Lys Gly Glu Ile Ser 
65                  70                  75                  80  


Asp Gly Tyr Ser Val Ser Arg Gln Ala Gln Ala Lys Phe Ser Leu Ser 
                85                  90                  95      


Leu Glu Ser Ala Ile Pro Asn Gln Thr Ala Leu Tyr Phe Cys Ala Thr 
            100                 105                 110         


Ser Gly Pro Asp Ser Asn Gln Pro Gln His Phe Gly Asp Gly Thr Arg 
        115                 120                 125             


Leu Ser Ile Leu Glu Asp Leu Asn Lys Val Phe Pro Pro Glu Val Ala 
    130                 135                 140                 


Val Phe Glu 
145         


<210>  33
<211>  147
<212>  PRT
<213>  Homo sapiens

<400>  33

Met Leu Leu Glu His Leu Leu Ile Ile Leu Trp Met Gln Leu Thr Trp 
1               5                   10                  15      


Val Ser Gly Gln Gln Leu Asn Gln Ser Pro Gln Ser Met Phe Ile Gln 
            20                  25                  30          


Glu Gly Glu Asp Val Ser Met Asn Cys Thr Ser Ser Ser Ile Phe Asn 
        35                  40                  45              


Thr Trp Leu Trp Tyr Lys Gln Glu Pro Gly Glu Gly Pro Val Leu Leu 
    50                  55                  60                  


Ile Ala Leu Tyr Lys Ala Gly Glu Leu Thr Ser Asn Gly Arg Leu Thr 
65                  70                  75                  80  


Ala Gln Phe Gly Ile Thr Arg Lys Asp Ser Phe Leu Asn Ile Ser Ala 
                85                  90                  95      


Ser Ile Pro Ser Asp Val Gly Ile Tyr Phe Cys Ala Gly Gln Leu Arg 
            100                 105                 110         


Tyr Gly Gly Ala Thr Asn Lys Leu Ile Phe Gly Thr Gly Thr Leu Leu 
        115                 120                 125             


Ala Val Gln Pro Asn Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu 
    130                 135                 140                 


Arg Asp Ser 
145         


<210>  34
<211>  147
<212>  PRT
<213>  Homo sapiens

<400>  34

Met Gly Cys Arg Leu Leu Cys Cys Val Ala Phe Cys Leu Leu Gly Ala 
1               5                   10                  15      


Gly Pro Val Asp Ser Gly Val Thr Gln Thr Pro Lys His Leu Ile Thr 
            20                  25                  30          


Ala Thr Gly Gln Arg Val Thr Leu Arg Cys Ser Pro Arg Ser Gly Asp 
        35                  40                  45              


Leu Ser Val Tyr Trp Tyr Gln Gln Ser Leu Asp Gln Gly Leu Gln Phe 
    50                  55                  60                  


Leu Ile His Tyr Tyr Asn Gly Glu Glu Arg Ala Lys Gly Asn Ile Leu 
65                  70                  75                  80  


Glu Arg Phe Ser Ala Gln Gln Phe Pro Asp Leu His Ser Glu Leu Asn 
                85                  90                  95      


Leu Ser Ser Leu Glu Leu Gly Asp Ser Ala Leu Tyr Phe Cys Ala Ser 
            100                 105                 110         


Ser Val Gly Gly Ala Ser Tyr Glu Gln Tyr Phe Gly Pro Gly Thr Arg 
        115                 120                 125             


Leu Thr Val Thr Glu Asp Leu Lys Asn Val Phe Pro Pro Glu Val Ala 
    130                 135                 140                 


Val Phe Glu 
145         


<210>  35
<211>  144
<212>  PRT
<213>  Homo sapiens

<400>  35

Met Arg Gln Val Ala Arg Val Ile Val Phe Leu Thr Leu Ser Thr Leu 
1               5                   10                  15      


Ser Leu Ala Lys Thr Thr Gln Pro Ile Ser Met Asp Ser Tyr Glu Gly 
            20                  25                  30          


Gln Glu Val Asn Ile Thr Cys Ser His Asn Asn Ile Ala Thr Asn Asp 
        35                  40                  45              


Tyr Ile Thr Trp Tyr Gln Gln Phe Pro Ser Gln Gly Pro Arg Phe Ile 
    50                  55                  60                  


Ile Gln Gly Tyr Lys Thr Lys Val Thr Asn Glu Val Ala Ser Leu Phe 
65                  70                  75                  80  


Ile Pro Ala Asp Arg Lys Ser Ser Thr Leu Ser Leu Pro Arg Val Ser 
                85                  90                  95      


Leu Ser Asp Thr Ala Val Tyr Tyr Cys Leu Val Gly Pro Thr Tyr Asn 
            100                 105                 110         


Gln Gly Gly Lys Leu Ile Phe Gly Gln Gly Thr Glu Leu Ser Val Lys 
        115                 120                 125             


Pro Asn Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg Asp Ser 
    130                 135                 140                 


<210>  36
<211>  143
<212>  PRT
<213>  Homo sapiens

<400>  36

Met Leu Leu Leu Leu Leu Leu Leu Gly Pro Gly Ser Gly Leu Gly Ala 
1               5                   10                  15      


Val Val Ser Gln His Pro Ser Arg Val Ile Cys Lys Ser Gly Thr Ser 
            20                  25                  30          


Val Lys Ile Glu Cys Arg Ser Leu Asp Phe Gln Ala Thr Thr Met Phe 
        35                  40                  45              


Trp Tyr Arg Gln Phe Pro Lys Lys Ser Leu Met Leu Met Ala Thr Ser 
    50                  55                  60                  


Asn Glu Gly Ser Lys Ala Thr Tyr Glu Gln Gly Val Glu Lys Asp Lys 
65                  70                  75                  80  


Phe Leu Ile Asn His Ala Ser Leu Thr Leu Ser Thr Leu Thr Val Thr 
                85                  90                  95      


Ser Ala His Pro Glu Asp Ser Ser Phe Tyr Ile Cys Ser Ala Arg Thr 
            100                 105                 110         


Ala Glu Val Glu Leu Phe Phe Gly Ser Gly Thr Gln Leu Ser Val Leu 
        115                 120                 125             


Glu Asp Leu Asn Lys Val Phe Pro Pro Glu Val Ala Val Phe Glu 
    130                 135                 140             


<210>  37
<211>  150
<212>  PRT
<213>  Homo sapiens

<400>  37

Met Lys Thr Phe Ala Gly Phe Ser Phe Leu Phe Leu Trp Leu Gln Leu 
1               5                   10                  15      


Asp Cys Met Ser Arg Gly Glu Asp Val Glu Gln Ser Leu Phe Leu Ser 
            20                  25                  30          


Val Arg Glu Gly Asp Ser Ser Val Ile Asn Cys Thr Tyr Thr Asp Ser 
        35                  40                  45              


Ser Ser Thr Tyr Leu Tyr Trp Tyr Lys Gln Glu Pro Gly Ala Gly Leu 
    50                  55                  60                  


Gln Leu Leu Thr Tyr Ile Phe Ser Asn Met Asp Met Lys Gln Asp Gln 
65                  70                  75                  80  


Arg Leu Thr Val Leu Leu Asn Lys Lys Asp Lys His Leu Ser Leu Arg 
                85                  90                  95      


Ile Ala Asp Thr Gln Thr Gly Asp Ser Ala Ile Tyr Phe Cys Ala Val 
            100                 105                 110         


Ala Ser Trp Gly Ser Gly Ser Ala Arg Gln Leu Thr Phe Gly Ser Gly 
        115                 120                 125             


Thr Gln Leu Thr Val Leu Pro Asp Ile Gln Asn Pro Asp Pro Ala Val 
    130                 135                 140                 


Tyr Gln Leu Arg Asp Ser 
145                 150 


<210>  38
<211>  146
<212>  PRT
<213>  Homo sapiens

<400>  38

Met Gly Thr Arg Leu Leu Cys Trp Ala Leu Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Gly Leu Val Asp Ala Gly Val Thr Gln Ser Pro Thr His Leu Ile Lys 
            20                  25                  30          


Thr Arg Gly Gln Gln Val Thr Leu Arg Cys Ser Pro Lys Ser Gly His 
        35                  40                  45              


Asp Thr Val Ser Trp Tyr Gln Gln Ala Leu Gly Gln Gly Pro Gln Phe 
    50                  55                  60                  


Ile Phe Gln Tyr Tyr Glu Glu Glu Glu Arg Gln Arg Gly Asn Phe Pro 
65                  70                  75                  80  


Asp Arg Phe Ser Gly His Gln Phe Pro Asn Tyr Ser Ser Glu Leu Asn 
                85                  90                  95      


Val Asn Ala Leu Leu Leu Gly Asp Ser Ala Leu Tyr Leu Cys Ala Ser 
            100                 105                 110         


Ser Leu Asp Ala Gly Tyr Glu Gln Tyr Phe Gly Pro Gly Thr Arg Leu 
        115                 120                 125             


Thr Val Thr Glu Asp Leu Lys Asn Val Phe Pro Pro Glu Val Ala Val 
    130                 135                 140                 


Phe Glu 
145     


<210>  39
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  39

Met Pro Phe Ala Thr Pro Met Glu Ala Glu Leu 
1               5                   10      


<210>  40
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  40

Met Pro Phe Ala Thr Pro Met Glu Ala 
1               5                   


<210>  41
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  41

Phe Ala Thr Pro Met Glu Ala Glu Leu 
1               5                   


<210>  42
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  42

Lys Glu Phe Thr Val Ser Gly Asn Ile Leu 
1               5                   10  


<210>  43
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  43

Thr Ser Tyr Val Lys Val Leu His His Met Val Lys Ile Ser Gly 
1               5                   10                  15  


<210>  44
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  44

Glu Val Asp Pro Ile Gly His Leu Tyr 
1               5                   


<210>  45
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  45

Cys Ala Pro Asn Asp Tyr Lys Leu Ser Phe 
1               5                   10  


<210>  46
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  46

Cys Ala Ser Ser Phe Ser Ser Asp Asn Glu Gln Phe Phe 
1               5                   10              


<210>  47
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  47

Cys Ala Thr Asp Ser Asn Asp Tyr Lys Leu Ser Phe 
1               5                   10          


<210>  48
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  48

Cys Ala Ser Ser Trp Gly Gly Glu Leu Phe Phe 
1               5                   10      


<210>  49
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  49

Cys Ala Tyr Arg Ser Asp Ala Gly Gly Thr Ser Tyr Gly Lys Leu Thr 
1               5                   10                  15      


Phe 
    


<210>  50
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  50

Cys Ala Ser Ser Pro Arg Thr Gly Gly Ala Gly Asn Thr Ile Tyr Phe 
1               5                   10                  15      


<210>  51
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  51

Cys Ala Val Arg Asp Ile Glu Val Val Asn Ala Gly Asn Met Leu Thr 
1               5                   10                  15      


Phe 
    


<210>  52
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  52

Cys Ala Ser Thr Asp Arg Val Arg Tyr Glu Gln Phe Phe 
1               5                   10              


<210>  53
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  53

Cys Ala Val Ser Asp Gly Gly Ala Thr Asn Lys Leu Ile Phe 
1               5                   10                  


<210>  54
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  54

Cys Ala Ser Ser Ser Gly Gly Arg Ala Ser Phe Thr Gln Tyr Phe 
1               5                   10                  15  


<210>  55
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  55

Cys Ala Leu Ser Asp Pro Asn Asn Gln Gly Gly Lys Leu Ile Phe 
1               5                   10                  15  


<210>  56
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  56

Cys Ala Ser Ser Gln Val Arg Gly Thr Thr Glu Ala Phe Phe 
1               5                   10                  


<210>  57
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  57

Cys Ala Phe Leu Gly Ser Gly Asn Thr Gly Lys Leu Ile Phe 
1               5                   10                  


<210>  58
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  58

Cys Ser Ala Ile Arg Pro Ser Gly Gly Ala Phe Glu Gln Tyr Phe 
1               5                   10                  15  


<210>  59
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  59

Cys Ala Ala Arg Ala Thr Ser Gly Thr Tyr Lys Tyr Ile Phe 
1               5                   10                  


<210>  60
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  60

Cys Ser Ala Ser Phe Ser Arg Asp Ile Glu Thr Gln Tyr Phe 
1               5                   10                  


<210>  61
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  61

Cys Leu Val Gly Pro Thr Tyr Asn Gln Gly Gly Lys Leu Ile Phe 
1               5                   10                  15  


<210>  62
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  62

Cys Ser Ala Arg Thr Ala Glu Val Glu Leu Phe Phe 
1               5                   10          


<210>  63
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  63

Cys Ala Val Ala Ser Trp Gly Ser Gly Ser Ala Arg Gln Leu Thr Phe 
1               5                   10                  15      


<210>  64
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  64

Cys Ala Ser Ser Leu Asp Ala Gly Tyr Glu Gln Tyr Phe 
1               5                   10              


<210>  65
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  65

Cys Ala Glu Pro Asn Thr Asp Lys Leu Ile Phe 
1               5                   10      


<210>  66
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  66

Cys Ala Thr Asn Tyr Asp Arg Gly Tyr Glu Gln Tyr Phe 
1               5                   10              


<210>  67
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  67

Cys Ala Val Trp Ala Thr Gly Asn Gln Phe Tyr Phe 
1               5                   10          


<210>  68
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  68

Cys Ala Thr Ser Phe Asp Arg Gly Tyr Glu Gln Tyr Phe 
1               5                   10              


<210>  69
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  69

Cys Val Val Asn Glu Arg Asn Ser Gly Tyr Ala Leu Asn Phe 
1               5                   10                  


<210>  70
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  70

Cys Ala Thr Ser Gly Pro Asp Ser Asn Gln Pro Gln His Phe 
1               5                   10                  


<210>  71
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  71

Cys Ala Val Arg Leu Gly Asp Ala Gly Asn Met Leu Thr Phe 
1               5                   10                  


<210>  72
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  72

Cys Ala Ser Ser Val Gly Arg Gly Met Asn Thr Glu Ala Phe Phe 
1               5                   10                  15  


<210>  73
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  73

Cys Ala Asp Asn Ala Gly Asn Met Leu Thr Phe 
1               5                   10      


<210>  74
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  74

Cys Ser Ala Arg Asp Pro Gly Arg Asn Tyr Gly Tyr Thr Phe 
1               5                   10                  


<210>  75
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  75

Cys Gly Asp Asn Ala Gly Asn Met Leu Thr Phe 
1               5                   10      


<210>  76
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  76

Cys Ser Ala Arg Asp Glu Asp Arg Pro Tyr Gly Tyr Thr Phe 
1               5                   10                  


<210>  77
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  77

Cys Ala Gly Gln Leu Arg Tyr Gly Gly Ala Thr Asn Lys Leu Ile Phe 
1               5                   10                  15      


<210>  78
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  78

Cys Ala Ser Ser Val Gly Gly Ala Ser Tyr Glu Gln Tyr Phe 
1               5                   10                  


<210>  79
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide

<400>  79
gccaccatga tcctaaacaa agctctgmtg c                                      31


<210>  80
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide

<400>  80
tatgcgatcg ctcacaakgg cccytggtgt ctg                                    33


<210>  81
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide

<400>  81
catcacagga actttctggg ctg                                               23


<210>  82
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide

<400>  82
gctggtagga caccgaggta aagc                                              24


<210>  83
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide

<400>  83
gctggtaaga ctcggaggtg aagc                                              24


<210>  84
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide

<400>  84
cacgtggtcg gggwagaagc                                                   20


<210>  85
<211>  53
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide


<220>
<221>  misc_feature
<222>  (26)..(30)
<223>  Variable

<400>  85
cgatccagac tagacgctca ggaagnnnnn aagcagtggt atcaacgcag agt              53


<210>  86
<211>  53
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide

<400>  86
caatatgtga ccgccgagtc ccaggttaga gtctctcagc tggtacacgg cag              53


<210>  87
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide

<400>  87
caatatgtga ccgccgagtc ccaggggctc aaacacagcg acctcgggtg                  50


<210>  88
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(5)
<223>  Variable

<400>  88
nnnnncgatc cagactagac gctcaggaag                                        30


<210>  89
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(5)
<223>  Variable

<400>  89
nnnnncaata tgtgaccgcc gagtcccagg                                        30


<210>  90
<211>  189
<212>  PRT
<213>  Homo sapiens

<400>  90

Met Thr Glu Tyr Lys Leu Val Val Val Gly Ala Gly Gly Val Gly Lys 
1               5                   10                  15      


Ser Ala Leu Thr Ile Gln Leu Ile Gln Asn His Phe Val Asp Glu Tyr 
            20                  25                  30          


Asp Pro Thr Ile Glu Asp Ser Tyr Arg Lys Gln Val Val Ile Asp Gly 
        35                  40                  45              


Glu Thr Cys Leu Leu Asp Ile Leu Asp Thr Ala Gly Gln Glu Glu Tyr 
    50                  55                  60                  


Ser Ala Met Arg Asp Gln Tyr Met Arg Thr Gly Glu Gly Phe Leu Cys 
65                  70                  75                  80  


Val Phe Ala Ile Asn Asn Thr Lys Ser Phe Glu Asp Ile His His Tyr 
                85                  90                  95      


Arg Glu Gln Ile Lys Arg Val Lys Asp Ser Glu Asp Val Pro Met Val 
            100                 105                 110         


Leu Val Gly Asn Lys Cys Asp Leu Pro Ser Arg Thr Val Asp Thr Lys 
        115                 120                 125             


Gln Ala Gln Asp Leu Ala Arg Ser Tyr Gly Ile Pro Phe Ile Glu Thr 
    130                 135                 140                 


Ser Ala Lys Thr Arg Gln Arg Val Glu Asp Ala Phe Tyr Thr Leu Val 
145                 150                 155                 160 


Arg Glu Ile Arg Gln Tyr Arg Leu Lys Lys Ile Ser Lys Glu Glu Lys 
                165                 170                 175     


Thr Pro Gly Cys Val Lys Ile Lys Lys Cys Ile Ile Met 
            180                 185                 


<210>  91
<211>  146
<212>  PRT
<213>  Homo sapiens

<400>  91

Met Glu Thr Val Leu Gln Val Leu Leu Gly Ile Leu Gly Phe Gln Ala 
1               5                   10                  15      


Ala Trp Val Ser Ser Gln Glu Leu Glu Gln Ser Pro Gln Ser Leu Ile 
            20                  25                  30          


Val Gln Glu Gly Lys Asn Leu Thr Ile Asn Cys Thr Ser Ser Lys Thr 
        35                  40                  45              


Leu Tyr Gly Leu Tyr Trp Tyr Lys Gln Lys Tyr Gly Glu Gly Leu Ile 
    50                  55                  60                  


Phe Leu Met Met Leu Gln Lys Gly Gly Glu Glu Lys Ser His Glu Lys 
65                  70                  75                  80  


Ile Thr Ala Lys Leu Asp Glu Lys Lys Gln Gln Ser Ser Leu His Ile 
                85                  90                  95      


Thr Ala Ser Gln Pro Ser His Ala Gly Ile Tyr Leu Cys Gly Ala Asp 
            100                 105                 110         


Met Leu Asp Tyr Gln Lys Val Thr Phe Gly Ile Gly Thr Lys Leu Gln 
        115                 120                 125             


Val Ile Pro Asn Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg 
    130                 135                 140                 


Asp Ser 
145     


<210>  92
<211>  146
<212>  PRT
<213>  Homo sapiens

<400>  92

Met Gly Ser Trp Thr Leu Cys Cys Val Ser Leu Cys Ile Leu Val Ala 
1               5                   10                  15      


Lys His Thr Asp Ala Gly Val Ile Gln Ser Pro Arg His Glu Val Thr 
            20                  25                  30          


Glu Met Gly Gln Glu Val Thr Leu Arg Cys Lys Pro Ile Ser Gly His 
        35                  40                  45              


Asp Tyr Leu Phe Trp Tyr Arg Gln Thr Met Met Arg Gly Leu Glu Leu 
    50                  55                  60                  


Leu Ile Tyr Phe Asn Asn Asn Val Pro Ile Asp Asp Ser Gly Met Pro 
65                  70                  75                  80  


Glu Asp Arg Phe Ser Ala Lys Met Pro Asn Ala Ser Phe Ser Thr Leu 
                85                  90                  95      


Lys Ile Gln Pro Ser Glu Pro Arg Asp Ser Ala Val Tyr Phe Cys Ala 
            100                 105                 110         


Ser Arg Arg Gly Gly Ser Glu Gln Tyr Phe Gly Pro Gly Thr Arg Leu 
        115                 120                 125             


Thr Val Thr Glu Asp Leu Lys Asn Val Phe Pro Pro Glu Val Ala Val 
    130                 135                 140                 


Phe Glu 
145     


<210>  93
<211>  151
<212>  PRT
<213>  Homo sapiens

<400>  93

Met Ser Leu Ser Ser Leu Leu Lys Val Val Thr Ala Ser Leu Trp Leu 
1               5                   10                  15      


Gly Pro Gly Ile Ala Gln Lys Ile Thr Gln Thr Gln Pro Gly Met Phe 
            20                  25                  30          


Val Gln Glu Lys Glu Ala Val Thr Leu Asp Cys Thr Tyr Asp Thr Ser 
        35                  40                  45              


Asp Pro Ser Tyr Gly Leu Phe Trp Tyr Lys Gln Pro Ser Ser Gly Glu 
    50                  55                  60                  


Met Ile Phe Leu Ile Tyr Gln Gly Ser Tyr Asp Gln Gln Asn Ala Thr 
65                  70                  75                  80  


Glu Gly Arg Tyr Ser Leu Asn Phe Gln Lys Ala Arg Lys Ser Ala Asn 
                85                  90                  95      


Leu Val Ile Ser Ala Ser Gln Leu Gly Asp Ser Ala Met Tyr Phe Cys 
            100                 105                 110         


Ala Met Arg Glu Gly Gln Asp Ser Ser Tyr Lys Leu Ile Phe Gly Ser 
        115                 120                 125             


Gly Thr Arg Leu Leu Val Arg Pro Asp Ile Gln Asn Pro Asp Pro Ala 
    130                 135                 140                 


Val Tyr Gln Leu Arg Asp Ser 
145                 150     


<210>  94
<211>  147
<212>  PRT
<213>  Homo sapiens

<400>  94

Met Gly Thr Arg Leu Leu Cys Cys Val Ala Phe Cys Leu Leu Gly Ala 
1               5                   10                  15      


Gly Pro Val Asp Ser Gly Val Thr Gln Thr Pro Lys His Leu Ile Thr 
            20                  25                  30          


Ala Thr Gly Gln Arg Val Thr Leu Arg Cys Ser Pro Arg Ser Gly Asp 
        35                  40                  45              


Leu Ser Val Tyr Trp Tyr Gln Gln Ser Leu Asp Gln Gly Leu Gln Phe 
    50                  55                  60                  


Leu Ile Gln Tyr Tyr Asn Gly Glu Glu Arg Ala Lys Gly Asn Ile Leu 
65                  70                  75                  80  


Glu Arg Phe Ser Ala Gln Gln Phe Pro Asp Leu His Ser Glu Leu Asn 
                85                  90                  95      


Leu Ser Ser Leu Glu Leu Gly Asp Ser Ala Leu Tyr Phe Cys Ala Ser 
            100                 105                 110         


Ser Val Leu Gly Pro Asn Thr Glu Ala Phe Phe Gly Gln Gly Thr Arg 
        115                 120                 125             


Leu Thr Val Val Glu Asp Leu Asn Lys Val Phe Pro Pro Glu Val Ala 
    130                 135                 140                 


Val Phe Glu 
145         


<210>  95
<211>  152
<212>  PRT
<213>  Homo sapiens

<400>  95

Met Leu Thr Ala Ser Leu Leu Arg Ala Val Ile Ala Ser Ile Cys Val 
1               5                   10                  15      


Val Ser Ser Met Ala Gln Lys Val Thr Gln Ala Gln Thr Glu Ile Ser 
            20                  25                  30          


Val Val Glu Lys Glu Asp Val Thr Leu Asp Cys Val Tyr Glu Thr Arg 
        35                  40                  45              


Asp Thr Thr Tyr Tyr Leu Phe Trp Tyr Lys Gln Pro Pro Ser Gly Glu 
    50                  55                  60                  


Leu Val Phe Leu Ile Arg Arg Asn Ser Phe Asp Glu Gln Asn Glu Ile 
65                  70                  75                  80  


Ser Gly Arg Tyr Ser Trp Asn Phe Gln Lys Ser Thr Ser Ser Phe Asn 
                85                  90                  95      


Phe Thr Ile Thr Ala Ser Gln Val Val Asp Ser Ala Val Tyr Phe Cys 
            100                 105                 110         


Ala Leu Ser Asn Ala Gly Gly Thr Ser Tyr Gly Lys Leu Thr Phe Gly 
        115                 120                 125             


Gln Gly Thr Ile Leu Thr Val His Pro Asn Ile Gln Asn Pro Asp Pro 
    130                 135                 140                 


Ala Val Tyr Gln Leu Arg Asp Ser 
145                 150         


<210>  96
<211>  148
<212>  PRT
<213>  Homo sapiens

<400>  96

Met Gly Pro Gln Leu Leu Gly Tyr Val Val Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Gly Pro Leu Glu Ala Gln Val Thr Gln Asn Pro Arg Tyr Leu Ile Thr 
            20                  25                  30          


Val Thr Gly Lys Lys Leu Thr Val Thr Cys Ser Gln Asn Met Asn His 
        35                  40                  45              


Glu Tyr Met Ser Trp Tyr Arg Gln Asp Pro Gly Leu Gly Leu Arg Gln 
    50                  55                  60                  


Ile Tyr Tyr Ser Met Asn Val Glu Val Thr Asp Lys Gly Asp Val Pro 
65                  70                  75                  80  


Glu Gly Tyr Lys Val Ser Arg Lys Glu Lys Arg Asn Phe Pro Leu Ile 
                85                  90                  95      


Leu Glu Ser Pro Ser Pro Asn Gln Thr Ser Leu Tyr Phe Cys Ala Ser 
            100                 105                 110         


Ser Arg Arg Leu Pro Pro Pro Tyr Gly Tyr Thr Phe Gly Ser Gly Thr 
        115                 120                 125             


Arg Leu Thr Val Val Glu Asp Leu Asn Lys Val Phe Pro Pro Glu Val 
    130                 135                 140                 


Ala Val Phe Glu 
145             


<210>  97
<211>  150
<212>  PRT
<213>  Homo sapiens

<400>  97

Met Leu Thr Ala Ser Leu Leu Arg Ala Val Ile Ala Ser Ile Cys Val 
1               5                   10                  15      


Val Ser Ser Met Ala Gln Lys Val Thr Gln Ala Gln Thr Glu Ile Ser 
            20                  25                  30          


Val Val Glu Lys Glu Asp Val Thr Leu Asp Cys Val Tyr Glu Thr Arg 
        35                  40                  45              


Asp Thr Thr Tyr Tyr Leu Phe Trp Tyr Lys Gln Pro Pro Ser Gly Glu 
    50                  55                  60                  


Leu Val Phe Leu Ile Arg Arg Asn Ser Phe Asp Glu Gln Asn Glu Ile 
65                  70                  75                  80  


Ser Gly Arg Tyr Ser Trp Asn Phe Gln Lys Ser Thr Ser Ser Phe Asn 
                85                  90                  95      


Phe Thr Ile Thr Ala Ser Gln Val Val Asp Ser Ala Val Tyr Phe Cys 
            100                 105                 110         


Ala Leu Ser Glu Ser Ser Asn Thr Gly Lys Leu Ile Phe Gly Gln Gly 
        115                 120                 125             


Thr Thr Leu Gln Val Lys Pro Asp Ile Gln Asn Pro Asp Pro Ala Val 
    130                 135                 140                 


Tyr Gln Leu Arg Asp Ser 
145                 150 


<210>  98
<211>  148
<212>  PRT
<213>  Homo sapiens

<400>  98

Met Gly Pro Gln Leu Leu Gly Tyr Val Val Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Gly Pro Leu Glu Ala Gln Val Thr Gln Asn Pro Arg Tyr Leu Ile Thr 
            20                  25                  30          


Val Thr Gly Lys Lys Leu Thr Val Thr Cys Ser Gln Asn Met Asn His 
        35                  40                  45              


Glu Tyr Met Ser Trp Tyr Arg Gln Asp Pro Gly Leu Gly Leu Arg Gln 
    50                  55                  60                  


Ile Tyr Tyr Ser Met Asn Val Glu Val Thr Asp Lys Gly Asp Val Pro 
65                  70                  75                  80  


Glu Gly Tyr Lys Val Ser Arg Lys Glu Lys Arg Asn Phe Pro Leu Ile 
                85                  90                  95      


Leu Glu Ser Pro Ser Pro Asn Gln Thr Ser Leu Tyr Phe Cys Ala Ser 
            100                 105                 110         


Ser Arg Arg Glu Pro Pro Pro Tyr Gly Tyr Thr Phe Gly Ser Gly Thr 
        115                 120                 125             


Arg Leu Thr Val Val Glu Asp Leu Asn Lys Val Phe Pro Pro Glu Val 
    130                 135                 140                 


Ala Val Phe Glu 
145             


<210>  99
<211>  151
<212>  PRT
<213>  Homo sapiens

<400>  99

Met Ser Leu Ser Ser Leu Leu Lys Val Val Thr Ala Ser Leu Trp Leu 
1               5                   10                  15      


Gly Pro Gly Ile Ala Gln Lys Ile Thr Gln Thr Gln Pro Gly Met Phe 
            20                  25                  30          


Val Gln Glu Lys Glu Ala Val Thr Leu Asp Cys Thr Tyr Asp Thr Ser 
        35                  40                  45              


Asp Pro Ser Tyr Gly Leu Phe Trp Tyr Lys Gln Pro Ser Ser Gly Glu 
    50                  55                  60                  


Met Ile Phe Leu Ile Tyr Gln Gly Ser Tyr Asp Gln Gln Asn Ala Thr 
65                  70                  75                  80  


Glu Gly Arg Tyr Ser Leu Asn Phe Gln Lys Ala Arg Lys Ser Ala Asn 
                85                  90                  95      


Leu Val Ile Ser Ala Ser Gln Leu Gly Asp Ser Ala Met Tyr Phe Cys 
            100                 105                 110         


Ala Met Arg Glu Ile Arg Asp Ser Ser Tyr Lys Leu Ile Phe Gly Ser 
        115                 120                 125             


Gly Thr Arg Leu Leu Val Arg Pro Asp Ile Gln Asn Pro Asp Pro Ala 
    130                 135                 140                 


Val Tyr Gln Leu Arg Asp Ser 
145                 150     


<210>  100
<211>  147
<212>  PRT
<213>  Homo sapiens

<400>  100

Met Gly Thr Arg Leu Leu Cys Cys Val Ala Phe Cys Leu Leu Gly Ala 
1               5                   10                  15      


Gly Pro Val Asp Ser Gly Val Thr Gln Thr Pro Lys His Leu Ile Thr 
            20                  25                  30          


Ala Thr Gly Gln Arg Val Thr Leu Arg Cys Ser Pro Arg Ser Gly Asp 
        35                  40                  45              


Leu Ser Val Tyr Trp Tyr Gln Gln Ser Leu Asp Gln Gly Leu Gln Phe 
    50                  55                  60                  


Leu Ile Gln His Tyr Asn Gly Glu Glu Arg Ala Lys Gly Asn Ile Leu 
65                  70                  75                  80  


Glu Arg Phe Ser Ala Gln Gln Phe Pro Asp Leu His Ser Glu Leu Asn 
                85                  90                  95      


Leu Ser Ser Leu Glu Leu Gly Asp Ser Ala Leu Tyr Phe Cys Ala Ser 
            100                 105                 110         


Ser Pro Ala Gly Pro Asn Thr Glu Ala Phe Phe Gly Gln Gly Thr Arg 
        115                 120                 125             


Leu Thr Val Val Glu Asp Leu Asn Lys Val Phe Pro Pro Glu Val Ala 
    130                 135                 140                 


Val Phe Glu 
145         


<210>  101
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  101

Ser Leu Leu Met Trp Ile Thr Gln Cys 
1               5                   


<210>  102
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  102

Ile Leu Asp Thr Ala Gly His Glu Glu Tyr 
1               5                   10  


<210>  103
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  103

Cys Gly Ala Asp Met Leu Asp Tyr Gln Lys Val Thr Phe 
1               5                   10              


<210>  104
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  104

Cys Ala Ser Arg Arg Gly Gly Ser Glu Gln Tyr Phe 
1               5                   10          


<210>  105
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  105

Cys Ala Met Arg Glu Gly Gln Asp Ser Ser Tyr Lys Leu Ile Phe 
1               5                   10                  15  


<210>  106
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  106

Cys Ala Ser Ser Val Leu Gly Pro Asn Thr Glu Ala Phe Phe 
1               5                   10                  


<210>  107
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  107

Cys Ala Leu Ser Asn Ala Gly Gly Thr Ser Tyr Gly Lys Leu Thr Phe 
1               5                   10                  15      


<210>  108
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  108

Cys Ala Ser Ser Arg Arg Leu Pro Pro Pro Tyr Gly Tyr Thr Phe 
1               5                   10                  15  


<210>  109
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  109

Cys Ala Leu Ser Glu Ser Ser Asn Thr Gly Lys Leu Ile Phe 
1               5                   10                  


<210>  110
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  110

Cys Ala Ser Ser Arg Arg Glu Pro Pro Pro Tyr Gly Tyr Thr Phe 
1               5                   10                  15  


<210>  111
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  111

Cys Ala Met Arg Glu Ile Arg Asp Ser Ser Tyr Lys Leu Ile Phe 
1               5                   10                  15  


<210>  112
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  112

Cys Ala Ser Ser Pro Ala Gly Pro Asn Thr Glu Ala Phe Phe 
1               5                   10                  


