                         SEQUENCE LISTING

<110>  Argonaute RNA Limited
 
<120>  Antagonist of PCSK9

<130>  4791P/WO

<150>  GB2003756.0
<151>  2020-03-16

<150>  GB2010276.0
<151>  2020-07-03

<150>  GB2013998.6
<151>  2020-09-06

<150>  GB2020553.0
<151>  2020-12-23

<160>  144   

<170>  PatentIn version 3.5

<210>  1
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense/antisense RNA

<400>  1
ccucauaggc cuggaguuua u                                                 21


<210>  2
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense/antisense RNA

<400>  2
aggccuggag uuuauucgga a                                                 21


<210>  3
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense/antisense RNA

<400>  3
cccucauagg ccuggaguuu a                                                 21


<210>  4
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense/antisense RNA

<400>  4
acccucauag gccuggaguu u                                                 21


<210>  5
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense/antisense RNA

<400>  5
uaggccugga guuuauucgg a                                                 21


<210>  6
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense/antisense RNA

<400>  6
aggucuggaa ugcaaaguca a                                                 21


<210>  7
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense/antisense RNA

<400>  7
ggccuggagu uuauucggaa a                                                 21


<210>  8
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense/antisense RNA

<400>  8
caggucugga augcaaaguc a                                                 21


<210>  9
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense/antisense RNA

<400>  9
ccucaccaag auccugcaug u                                                 21


<210>  10
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense/antisense RNA

<400>  10
caccagcaua cagagugacc a                                                 21


<210>  11
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense/antisense RNA

<400>  11
auaaacucca ggccuaugag g                                                 21


<210>  12
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense/antisense RNA

<400>  12
uuccgaauaa acuccaggcc u                                                 21


<210>  13
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense/antisense RNA

<400>  13
uaaacuccag gccuaugagg g                                                 21


<210>  14
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense/antisense RNA

<400>  14
aaacuccagg ccuaugaggg u                                                 21


<210>  15
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense/antisense RNA

<400>  15
uccgaauaaa cuccaggccu a                                                 21


<210>  16
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense/antisense RNA

<400>  16
uugacuuugc auuccagacc u                                                 21


<210>  17
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense/antisense RNA

<400>  17
uuuccgaaua aacuccaggc c                                                 21


<210>  18
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense/antisense RNA

<400>  18
ugacuuugca uuccagaccu g                                                 21


<210>  19
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense/antisense RNA

<400>  19
acaugcagga ucuuggugag g                                                 21


<210>  20
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense/antisense RNA

<400>  20
uggucacucu guaugcuggu g                                                 21


<210>  21
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense/antisense RNA

<400>  21
agcaagcaga cauuuaucuu u                                                 21


<210>  22
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense/antisense RNA

<400>  22
aggucuggaa ugcaaaguca a                                                 21


<210>  23
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense/antisense RNA

<400>  23
ggccuggagu uuauucggaa a                                                 21


<210>  24
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense/antisense RNA

<400>  24
caggucugga augcaaaguc a                                                 21


<210>  25
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense/antisense RNA

<400>  25
cccaagcaag cagacauuua u                                                 21


<210>  26
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense/antisense RNA

<400>  26
ccucaccaag auccugcaug u                                                 21


<210>  27
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense/antisense RNA

<400>  27
uuuucuagac cuguuuugcu u                                                 21


<210>  28
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense/antisense RNA

<400>  28
acccaagcaa gcagacauuu a                                                 21


<210>  29
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense/antisense RNA

<400>  29
caccagcaua cagagugacc a                                                 21


<210>  30
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense/antisense RNA

<400>  30
auucuggguu uuguagcauu u                                                 21


<210>  31
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense/antisense RNA

<400>  31
aucuccuaga caccagcaua c                                                 21


<210>  32
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense/antisense RNA

<400>  32
uccuagacac cagcauacag a                                                 21


<210>  33
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense/antisense RNA

<400>  33
gacauuuauc uuuugggucu g                                                 21


<210>  34
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense/antisense RNA

<400>  34
uauucugggu uuuguagcau u                                                 21


<210>  35
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense/antisense RNA

<400>  35
cuggaguuua uucggaaaag c                                                 21


<210>  36
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense/antisense RNA

<400>  36
gccuggaguu uauucggaaa a                                                 21


<210>  37
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense/antisense RNA

<400>  37
gaggcagaga cugauccacu u                                                 21


<210>  38
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense/antisense RNA

<400>  38
aagcaagcag acauuuaucu u                                                 21


<210>  39
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense/antisense RNA

<400>  39
uagaccuguu uugcuuuugu a                                                 21


<210>  40
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense/antisense RNA

<400>  40
uuugcuuuug uaacuugaag a                                                 21


<210>  41
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense/antisense RNA

<400>  41
cacuucucug ccaaagaugu c                                                 21


<210>  42
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense/antisense RNA

<400>  42
uugcuuuugu aacuugaaga u                                                 21


<210>  43
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense/antisense RNA

<400>  43
augcaaaguc aaggagcaug g                                                 21


<210>  44
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense/antisense RNA

<400>  44
cccacccaag caagcagaca u                                                 21


<210>  45
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense/antisense RNA

<400>  45
ggguaacagu gaggcuggga a                                                 21


<210>  46
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense/antisense RNA

<400>  46
ggucaugguc accgacuucg a                                                 21


<210>  47
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense/antisense RNA

<400>  47
ggcagcuguu uugcaggacu g                                                 21


<210>  48
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense/antisense RNA

<400>  48
gggcagguug gcagcuguuu u                                                 21


<210>  49
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense/antisense RNA

<400>  49
uugaagauau uuauucuggg u                                                 21


<210>  50
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense/antisense RNA

<400>  50
uggcagcugu uuugcaggac u                                                 21


<210>  51
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense/antisense RNA

<400>  51
ccggggauac cucaccaaga u                                                 21


<210>  52
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense/antisense RNA

<400>  52
acugauccac uucucugcca a                                                 21


<210>  53
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense/antisense RNA

<400>  53
auccacuucu cugccaaaga u                                                 21


<210>  54
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense/antisense RNA

<400>  54
acuucucugc caaagauguc a                                                 21


<210>  55
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense/antisense RNA

<400>  55
gucuggaaug caaagucaag g                                                 21


<210>  56
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense/antisense RNA

<400>  56
cuucucugcc aaagauguca u                                                 21


<210>  57
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense/antisense RNA

<400>  57
gaguugaggc agagacugau c                                                 21


<210>  58
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense/antisense RNA

<400>  58
gaccuguuuu gcuuuuguaa c                                                 21


<210>  59
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense/antisense RNA

<400>  59
cggggauacc ucaccaagau c                                                 21


<210>  60
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense/antisense RNA

<400>  60
uuucuagacc uguuuugcuu u                                                 21


<210>  61
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense/antisense RNA

<400>  61
ggucuggaau gcaaagucaa g                                                 21


<210>  62
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense/antisense RNA

<400>  62
uaucuccuag acaccagcau a                                                 21


<210>  63
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense/antisense RNA

<400>  63
agguuggcag cuguuuugca g                                                 21


<210>  64
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense/antisense RNA

<400>  64
aacuuuucua gaccuguuuu g                                                 21


<210>  65
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense/antisense RNA

<400>  65
cuuuucuaga ccuguuuugc u                                                 21


<210>  66
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense/antisense RNA

<400>  66
uccacuucuc ugccaaagau g                                                 21


<210>  67
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense/antisense RNA

<400>  67
uggaguuuau ucggaaaagc c                                                 21


<210>  68
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense/antisense RNA

<400>  68
ggcagguugg cagcuguuuu g                                                 21


<210>  69
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense/antisense RNA

<400>  69
uggaggugua ucuccuagac a                                                 21


<210>  70
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense/antisense RNA

<400>  70
gucaucaaug aggccugguu c                                                 21


<210>  71
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense/antisense RNA

<400>  71
uucuagaccu guuuugcuuu u                                                 21


<210>  72
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense/antisense RNA

<400>  72
uucuggguuu uguagcauuu u                                                 21


<210>  73
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense/antisense RNA

<400>  73
gagacugauc cacuucucug c                                                 21


<210>  74
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense/antisense RNA

<400>  74
agucaaggag cauggaaucc c                                                 21


<210>  75
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense/antisense RNA

<400>  75
aucuuuuggg ucuguccucu c                                                 21


<210>  76
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense/antisense RNA

<400>  76
cacccaagca agcagacauu u                                                 21


<210>  77
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense/antisense RNA

<400>  77
aaagauaaau gucugcuugc u                                                 21


<210>  78
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense/antisense RNA

<400>  78
uugacuuugc auuccagacc u                                                 21


<210>  79
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense/antisense RNA

<400>  79
uuuccgaaua aacuccaggc c                                                 21


<210>  80
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense/antisense RNA

<400>  80
ugacuuugca uuccagaccu g                                                 21


<210>  81
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense/antisense RNA

<400>  81
auaaaugucu gcuugcuugg g                                                 21


<210>  82
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense/antisense RNA

<400>  82
acaugcagga ucuuggugag g                                                 21


<210>  83
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense/antisense RNA

<400>  83
aagcaaaaca ggucuagaaa a                                                 21


<210>  84
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense/antisense RNA

<400>  84
uaaaugucug cuugcuuggg u                                                 21


<210>  85
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense/antisense RNA

<400>  85
uggucacucu guaugcuggu g                                                 21


<210>  86
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense/antisense RNA

<400>  86
aaaugcuaca aaacccagaa u                                                 21


<210>  87
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense/antisense RNA

<400>  87
guaugcuggu gucuaggaga u                                                 21


<210>  88
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense/antisense RNA

<400>  88
ucuguaugcu ggugucuagg a                                                 21


<210>  89
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense/antisense RNA

<400>  89
cagacccaaa agauaaaugu c                                                 21


<210>  90
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense/antisense RNA

<400>  90
aaugcuacaa aacccagaau a                                                 21


<210>  91
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense/antisense RNA

<400>  91
gcuuuuccga auaaacucca g                                                 21


<210>  92
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense/antisense RNA

<400>  92
uuuuccgaau aaacuccagg c                                                 21


<210>  93
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense/antisense RNA

<400>  93
aaguggauca gucucugccu c                                                 21


<210>  94
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense/antisense RNA

<400>  94
aagauaaaug ucugcuugcu u                                                 21


<210>  95
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense/antisense RNA

<400>  95
uacaaaagca aaacaggucu a                                                 21


<210>  96
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense/antisense RNA

<400>  96
ucuucaaguu acaaaagcaa a                                                 21


<210>  97
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense/antisense RNA

<400>  97
gacaucuuug gcagagaagu g                                                 21


<210>  98
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense/antisense RNA

<400>  98
aucuucaagu uacaaaagca a                                                 21


<210>  99
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense/antisense RNA

<400>  99
ccaugcuccu ugacuuugca u                                                 21


<210>  100
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense/antisense RNA

<400>  100
augucugcuu gcuugggugg g                                                 21


<210>  101
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense/antisense RNA

<400>  101
uucccagccu cacuguuacc c                                                 21


<210>  102
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense/antisense RNA

<400>  102
ucgaagucgg ugaccaugac c                                                 21


<210>  103
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense/antisense RNA

<400>  103
caguccugca aaacagcugc c                                                 21


<210>  104
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense/antisense RNA

<400>  104
aaaacagcug ccaaccugcc c                                                 21


<210>  105
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense/antisense RNA

<400>  105
acccagaaua aauaucuuca a                                                 21


<210>  106
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense/antisense RNA

<400>  106
aguccugcaa aacagcugcc a                                                 21


<210>  107
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense/antisense RNA

<400>  107
aucuugguga gguauccccg g                                                 21


<210>  108
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense/antisense RNA

<400>  108
uuggcagaga aguggaucag u                                                 21


<210>  109
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense/antisense RNA

<400>  109
aucuuuggca gagaagugga u                                                 21


<210>  110
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense/antisense RNA

<400>  110
ugacaucuuu ggcagagaag u                                                 21


<210>  111
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense/antisense RNA

<400>  111
ccuugacuuu gcauuccaga c                                                 21


<210>  112
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense/antisense RNA

<400>  112
augacaucuu uggcagagaa g                                                 21


<210>  113
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense/antisense RNA

<400>  113
gaucagucuc ugccucaacu c                                                 21


<210>  114
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense/antisense RNA

<400>  114
guuacaaaag caaaacaggu c                                                 21


<210>  115
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense/antisense RNA

<400>  115
gaucuuggug agguaucccc g                                                 21


<210>  116
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense/antisense RNA

<400>  116
aaagcaaaac aggucuagaa a                                                 21


<210>  117
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense/antisense RNA

<400>  117
cuugacuuug cauuccagac c                                                 21


<210>  118
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense/antisense RNA

<400>  118
uaugcuggug ucuaggagau a                                                 21


<210>  119
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense/antisense RNA

<400>  119
cugcaaaaca gcugccaacc u                                                 21


<210>  120
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense/antisense RNA

<400>  120
caaaacaggu cuagaaaagu u                                                 21


<210>  121
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense/antisense RNA

<400>  121
agcaaaacag gucuagaaaa g                                                 21


<210>  122
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense/antisense RNA

<400>  122
caucuuuggc agagaagugg a                                                 21


<210>  123
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense/antisense RNA

<400>  123
ggcuuuuccg aauaaacucc a                                                 21


<210>  124
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense/antisense RNA

<400>  124
caaaacagcu gccaaccugc c                                                 21


<210>  125
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense/antisense RNA

<400>  125
ugucuaggag auacaccucc a                                                 21


<210>  126
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense/antisense RNA

<400>  126
gaaccaggcc ucauugauga c                                                 21


<210>  127
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense/antisense RNA

<400>  127
aaaagcaaaa caggucuaga a                                                 21


<210>  128
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense/antisense RNA

<400>  128
aaaaugcuac aaaacccaga a                                                 21


<210>  129
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense/antisense RNA

<400>  129
gcagagaagu ggaucagucu c                                                 21


<210>  130
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense/antisense RNA

<400>  130
gggauuccau gcuccuugac u                                                 21


<210>  131
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense/antisense RNA

<400>  131
gagaggacag acccaaaaga u                                                 21


<210>  132
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense/antisense RNA

<400>  132
aaaugucugc uugcuugggu g                                                 21


<210>  133
<211>  19
<212>  DNA
<213>  artificial sequence

<220>
<223>  crook sequence

<400>  133
tcacctcatc ccgcgaagc                                                    19


<210>  134
<211>  3637
<212>  DNA
<213>  artificial sequence

<220>
<223>  PCSK9 cDNA sequence

<400>  134
agcgacgtcg aggcgctcat ggttgcaggc gggcgccgcc gttcagttca gggtctgagc       60

ctggaggagt gagccaggca gtgagactgg ctcgggcggg ccgggacgcg tcgttgcagc      120

agcggctccc agctcccagc caggattccg cgcgcccctt cacgcgccct gctcctgaac      180

ttcagctcct gcacagtcct ccccaccgca aggctcaagg cgccgccggc gtggaccgcg      240

cacggcctct aggtctcctc gccaggacag caacctctcc cctggccctc atgggcaccg      300

tcagctccag gcggtcctgg tggccgctgc cactgctgct gctgctgctg ctgctcctgg      360

gtcccgcggg cgcccgtgcg caggaggacg aggacggcga ctacgaggag ctggtgctag      420

ccttgcgttc cgaggaggac ggcctggccg aagcacccga gcacggaacc acagccacct      480

tccaccgctg cgccaaggat ccgtggaggt tgcctggcac ctacgtggtg gtgctgaagg      540

aggagaccca cctctcgcag tcagagcgca ctgcccgccg cctgcaggcc caggctgccc      600

gccggggata cctcaccaag atcctgcatg tcttccatgg ccttcttcct ggcttcctgg      660

tgaagatgag tggcgacctg ctggagctgg ccttgaagtt gccccatgtc gactacatcg      720

aggaggactc ctctgtcttt gcccagagca tcccgtggaa cctggagcgg attacccctc      780

cacggtaccg ggcggatgaa taccagcccc ccgacggagg cagcctggtg gaggtgtatc      840

tcctagacac cagcatacag agtgaccacc gggaaatcga gggcagggtc atggtcaccg      900

acttcgagaa tgtgcccgag gaggacggga cccgcttcca cagacaggcc agcaagtgtg      960

acagtcatgg cacccacctg gcaggggtgg tcagcggccg ggatgccggc gtggccaagg     1020

gtgccagcat gcgcagcctg cgcgtgctca actgccaagg gaagggcacg gttagcggca     1080

ccctcatagg cctggagttt attcggaaaa gccagctggt ccagcctgtg gggccactgg     1140

tggtgctgct gcccctggcg ggtgggtaca gccgcgtcct caacgccgcc tgccagcgcc     1200

tggcgagggc tggggtcgtg ctggtcaccg ctgccggcaa cttccgggac gatgcctgcc     1260

tctactcccc agcctcagct cccgaggtca tcacagttgg ggccaccaat gcccaagacc     1320

agccggtgac cctggggact ttggggacca actttggccg ctgtgtggac ctctttgccc     1380

caggggagga catcattggt gcctccagcg actgcagcac ctgctttgtg tcacagagtg     1440

ggacatcaca ggctgctgcc cacgtggctg gcattgcagc catgatgctg tctgccgagc     1500

cggagctcac cctggccgag ttgaggcaga gactgatcca cttctctgcc aaagatgtca     1560

tcaatgaggc ctggttccct gaggaccagc gggtactgac ccccaacctg gtggccgccc     1620

tgccccccag cacccatggg gcaggttggc agctgttttg caggactgta tggtcagcac     1680

actcggggcc tacacggatg gccacagccg tcgcccgctg cgccccagat gaggagctgc     1740

tgagctgctc cagtttctcc aggagtggga agcggcgggg cgagcgcatg gaggcccaag     1800

ggggcaagct ggtctgccgg gcccacaacg cttttggggg tgagggtgtc tacgccattg     1860

ccaggtgctg cctgctaccc caggccaact gcagcgtcca cacagctcca ccagctgagg     1920

ccagcatggg gacccgtgtc cactgccacc aacagggcca cgtcctcaca ggctgcagct     1980

cccactggga ggtggaggac cttggcaccc acaagccgcc tgtgctgagg ccacgaggtc     2040

agcccaacca gtgcgtgggc cacagggagg ccagcatcca cgcttcctgc tgccatgccc     2100

caggtctgga atgcaaagtc aaggagcatg gaatcccggc ccctcaggag caggtgaccg     2160

tggcctgcga ggagggctgg accctgactg gctgcagtgc cctccctggg acctcccacg     2220

tcctgggggc ctacgccgta gacaacacgt gtgtagtcag gagccgggac gtcagcacta     2280

caggcagcac cagcgaaggg gccgtgacag ccgttgccat ctgctgccgg agccggcacc     2340

tggcgcaggc ctcccaggag ctccagtgac agccccatcc caggatgggt gtctggggag     2400

ggtcaagggc tggggctgag ctttaaaatg gttccgactt gtccctctct cagccctcca     2460

tggcctggca cgaggggatg gggatgcttc cgcctttccg gggctgctgg cctggccctt     2520

gagtggggca gcctccttgc ctggaactca ctcactctgg gtgcctcctc cccaggtgga     2580

ggtgccagga agctccctcc ctcactgtgg ggcatttcac cattcaaaca ggtcgagctg     2640

tgctcgggtg ctgccagctg ctcccaatgt gccgatgtcc gtgggcagaa tgacttttat     2700

tgagctcttg ttccgtgcca ggcattcaat cctcaggtct ccaccaagga ggcaggattc     2760

ttcccatgga taggggaggg ggcggtaggg gctgcaggga caaacatcgt tggggggtga     2820

gtgtgaaagg tgctgatggc cctcatctcc agctaactgt ggagaagccc ctgggggctc     2880

cctgattaat ggaggcttag ctttctggat ggcatctagc cagaggctgg agacaggtgc     2940

gcccctggtg gtcacaggct gtgccttggt ttcctgagcc acctttactc tgctctatgc     3000

caggctgtgc tagcaacacc caaaggtggc ctgcggggag ccatcaccta ggactgactc     3060

ggcagtgtgc agtggtgcat gcactgtctc agccaacccg ctccactacc cggcagggta     3120

cacattcgca cccctacttc acagaggaag aaacctggaa ccagaggggg cgtgcctgcc     3180

aagctcacac agcaggaact gagccagaaa cgcagattgg gctggctctg aagccaagcc     3240

tcttcttact tcacccggct gggctcctca tttttacggg taacagtgag gctgggaagg     3300

ggaacacaga ccaggaagct cggtgagtga tggcagaacg atgcctgcag gcatggaact     3360

ttttccgtta tcacccaggc ctgattcact ggcctggcgg agatgcttct aaggcatggt     3420

cgggggagag ggccaacaac tgtccctcct tgagcaccag ccccacccaa gcaagcagac     3480

atttatcttt tgggtctgtc ctctctgttg cctttttaca gccaactttt ctagacctgt     3540

tttgcttttg taacttgaag atatttattc tgggttttgt agcattttta ttaatatggt     3600

gactttttaa aataaaaaca aacaaacgtt gtcctaa                              3637


<210>  135
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense unmodified inclisiran


<220>
<221>  deoxythymidine
<222>  (11)..(11)

<400>  135
cuagaccugu tuugcuuuug u                                                 21


<210>  136
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense unmodified inclisiran

<400>  136
acaaaagcaa aagaccucua gaa                                               23


<210>  137
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  apoB-1 sense

<400>  137
gucaucacac ugaauaccaa u                                                 21


<210>  138
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  apoB-1 antisense

<400>  138
auugguauuc agugugauga cac                                               23


<210>  139
<211>  21
<212>  DNA
<213>  artificial sequnence

<220>
<223>  beta-Gal sense

<400>  139
uugauguguu uagucgcuau u                                                 21


<210>  140
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  beta-Gal antisense

<400>  140
uagcgacuaa acacaucaau u                                                 21


<210>  141
<211>  19
<212>  DNA
<213>  artificial sequence

<220>
<223>  beta-gal 728 sense

<400>  141
cuacacaaau cagcgauuu                                                    19


<210>  142
<211>  19
<212>  DNA
<213>  artificial sequence

<220>
<223>  beta-gal 728 antisense

<400>  142
aaaucgcuga uuuguguag                                                    19


<210>  143
<211>  21
<212>  DNA
<213>  artificial sequnce

<220>
<223>  Luc-siRNA sense


<220>
<221>  dexoythymidine
<222>  (20)..(21)

<400>  143
uaaggcuaug aagagauact t                                                 21


<210>  144
<211>  21
<212>  DNA
<213>  artificial sequence listing

<220>
<223>  Luc-siRNA antisense

<400>  144
aaguaucucu ucauagccuu a                                                 21


