                         SEQUENCE LISTING

<110>  TSB THERAPEUTICS (BEIJING) CO. LTD.
 
<120>  ANTI-SARS-COV-2 ANTIBODIES AND USES THEREOF

<130>  072106-8001WO05

<160>  449   

<170>  PatentIn version 3.5

<210>  1
<211>  8
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P2A-1A8 HCDR1
<222>  (1)..(8)

<400>  1

Gly Phe Ala Phe Asp Asp Tyr Ala 
1               5               


<210>  2
<211>  8
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P2A-1A8 HCDR2
<222>  (1)..(8)

<400>  2

Ser Thr Trp Asn Ser Gly Thr Ile 
1               5               


<210>  3
<211>  23
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P2A-1A8 HCDR3
<222>  (1)..(23)

<400>  3

Ala Lys Leu Gly Gly Tyr Ser Asp Tyr Asp Tyr Pro Arg Pro Gly Asp 
1               5                   10                  15      


His Tyr Tyr Gly Leu Asp Val 
            20              


<210>  4
<211>  9
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P2A-1A8 LCDR1
<222>  (1)..(9)

<400>  4

Ser Ser Asp Val Gly Ser Tyr Asn Leu 
1               5                   


<210>  5
<211>  4
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P2A-1A8 LCDR2
<222>  (1)..(3)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa is absent.

<400>  5

Asp Val Asn Xaa 
1               


<210>  6
<211>  10
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P2A-1A8 LCDR3
<222>  (1)..(10)

<400>  6

Arg Ser Tyr Thr Asp Ser Asn Thr Tyr Val 
1               5                   10  


<210>  7
<211>  130
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P2A-1A8 VH
<222>  (1)..(130)

<400>  7

Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ala Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ser Thr Trp Asn Ser Gly Thr Ile Ala Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Lys Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Thr Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Leu Gly Gly Tyr Ser Asp Tyr Asp Tyr Pro Arg Pro Gly Asp 
            100                 105                 110         


His Tyr Tyr Gly Leu Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val 
        115                 120                 125             


Ser Ser 
    130 


<210>  8
<211>  110
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P2A-1A8 VL
<222>  (1)..(110)

<400>  8

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Ser Tyr 
            20                  25                  30          


Asn Leu Val Ser Trp Tyr Gln Gln His Pro Gly Lys Val Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Asp Val Asn Lys Arg Pro Ser Gly Ile Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Arg Ser Tyr Thr Asp Ser 
                85                  90                  95      


Asn Thr Tyr Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu 
            100                 105                 110 


<210>  9
<211>  390
<212>  DNA
<213>  Homo sapiens


<220>
<221>  P2A-1A8 VHnu
<222>  (1)..(390)

<400>  9
gaagtgcagc tggtggagtc tgggggagac ttggtacagc ctggcaggtc cctgagactc       60

tcctgcgcag cctctggatt cgcctttgat gattatgcca tgcactgggt ccggcaagct      120

ccagggaagg gcctggagtg ggtctcaggt agtacttgga atagtgggac catagcctat      180

gcggactctg tgaagggccg attcaccatc tccagagaca acgccaagaa gtccctgtat      240

ctgcaaatga acagtctgag aactgaggac acggccttat attactgtgc aaagttgggg      300

ggctacagtg actacgatta cccgaggccg ggagaccact attacggttt ggacgtctgg      360

ggccaaggga ccacggtcac cgtctcctca                                       390


<210>  10
<211>  330
<212>  DNA
<213>  Homo sapiens


<220>
<221>  P2A-1A8 VLnu
<222>  (1)..(330)

<400>  10
cagtctgccc tgactcagcc tgcctccgtg tctgggtctc ctggacagtc gatcaccatc       60

tcctgcactg gaaccagcag tgatgttggg agttataacc ttgtctcctg gtaccaacag      120

cacccaggca aagtccccaa actcttgatt tatgatgtca ataagcggcc ctcagggatt      180

tccaatcgct tctctggctc caagtctggc aacacggcct ccctgaccat ctctgggctc      240

caggctgagg acgaggctga ttattactgc agatcatata cagacagcaa cacttatgtc      300

ttcggaactg ggaccaaggt caccgtccta                                       330


<210>  11
<211>  8
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P2A-1A9/P2B-2G11 HCDR1
<222>  (1)..(8)

<400>  11

Gly Phe Thr Phe Asp Asp Tyr Ala 
1               5               


<210>  12
<211>  8
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P2A-1A9/P2B-2G11 HCDR2
<222>  (1)..(8)

<400>  12

Ile Ser Trp Asn Gly Gly Ile Ile 
1               5               


<210>  13
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P2A-1A9/P2B-2G11 HCDR3
<222>  (1)..(17)

<400>  13

Ala Lys Val Ala Gly Arg Gly Asp Tyr Asp Tyr Tyr Tyr Gly Met Asp 
1               5                   10                  15      


Val 
    


<210>  14
<211>  9
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P2A-1A9/P2B-2G11 LCDR1
<222>  (1)..(9)

<400>  14

Ser Ser Asn Ile Gly Ala Gly Tyr Asp 
1               5                   


<210>  15
<211>  4
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P2A-1A9/P2B-2G11 LCDR2
<222>  (1)..(3)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa is absent.

<400>  15

Gly Asn Asn Xaa 
1               


<210>  16
<211>  11
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P2A-1A9/P2B-2G11 LCDR3
<222>  (1)..(11)

<400>  16

Gln Ser Tyr Asp Ser Ser Leu Ser Gly Ser Val 
1               5                   10      


<210>  17
<211>  124
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P2A-1A9 VH
<222>  (1)..(124)

<400>  17

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Val Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Gly Gly Ile Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Val Ala Gly Arg Gly Asp Tyr Asp Tyr Tyr Tyr Gly Met Asp 
            100                 105                 110         


Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 


<210>  18
<211>  111
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P2A-1A9 VL
<222>  (1)..(111)

<400>  18

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gly Asn Asn Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 
                85                  90                  95      


Leu Ser Gly Ser Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110     


<210>  19
<211>  372
<212>  DNA
<213>  Homo sapiens


<220>
<221>  P2A-1A9 VHnu
<222>  (1)..(372)

<400>  19
gaagtgcagc tggtggagtc tgggggaggc ttggtacagc ctggcaggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgat gattatgcca tgcactgggt ccggcaagtt      120

ccagggaagg gcctggagtg ggtctcaggt attagttgga atggtggtat cataggctac      180

gcggactctg tgaagggccg attcaccatc tccagagaca acgccaagac ttccctgtat      240

ctgcaaatga acagtctgag agctgaggac acggccttgt attactgtgc aaaagtcgcg      300

ggaagggggg attacgacta ttactatggt atggacgtct ggggccaagg gaccacggtc      360

accgtctcct ca                                                          372


<210>  20
<211>  333
<212>  DNA
<213>  Homo sapiens


<220>
<221>  P2A-1A9 VLnu
<222>  (1)..(333)

<400>  20
cagtctgtgc tgacgcagcc gccctcagtg tctggggccc cagggcagag ggtcaccatc       60

tcctgcactg ggagcagctc caacatcggg gcaggttatg atgtacactg gtaccagcaa      120

cttccaggaa cagcccccaa actcctcatc tatggtaaca acaatcgccc ctcaggggtc      180

cctgaccgat tctctggctc caagtctggc acctcagcct ccctggccat cactgggctc      240

caggctgagg atgaggctga ttattactgc cagtcctatg acagcagcct gagtggttcg      300

gtattcggcg gagggaccaa gctgaccgtc cta                                   333


<210>  21
<211>  8
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P2A-1A10 HCDR1
<222>  (1)..(8)

<400>  21

Gly Tyr Thr Phe Thr Gly Tyr Tyr 
1               5               


<210>  22
<211>  8
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P2A-1A10 HCDR2
<222>  (1)..(8)

<400>  22

Ile Asn Pro Asn Ser Gly Gly Thr 
1               5               


<210>  23
<211>  19
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P2A-1A10 HCDR3
<222>  (1)..(19)

<400>  23

Ala Arg Val Pro Tyr Cys Ser Ser Thr Ser Cys His Arg Asp Trp Tyr 
1               5                   10                  15      


Phe Asp Leu 
            


<210>  24
<211>  12
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P2A-1A10 LCDR1
<222>  (1)..(12)

<400>  24

Gln Ser Leu Leu Asp Ser Asp Asp Gly Asn Thr Tyr 
1               5                   10          


<210>  25
<211>  4
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P2A-1A10 LCDR2
<222>  (1)..(3)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa is absent.

<400>  25

Thr Leu Ser Xaa 
1               


<210>  26
<211>  9
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P2A-1A10 LCDR3
<222>  (1)..(9)

<400>  26

Met Gln Arg Ile Glu Phe Pro Leu Thr 
1               5                   


<210>  27
<211>  126
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P2A-1A10 VH
<222>  (1)..(126)

<400>  27

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Asn Pro Asn Ser Gly Gly Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Val Pro Tyr Cys Ser Ser Thr Ser Cys His Arg Asp Trp Tyr 
            100                 105                 110         


Phe Asp Leu Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125     


<210>  28
<211>  113
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P2A-1A10 VL
<222>  (1)..(113)

<400>  28

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu Asp Ser 
            20                  25                  30          


Asp Asp Gly Asn Thr Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Gln Leu Leu Ile Tyr Thr Leu Ser Tyr Arg Ala Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys 
65                  70                  75                  80  


Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln 
                85                  90                  95      


Arg Ile Glu Phe Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys 
    


<210>  29
<211>  378
<212>  DNA
<213>  Homo sapiens


<220>
<221>  P2A-1A10 VHnu
<222>  (1)..(378)

<400>  29
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggata caccttcacc ggctactata tgcactgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggacgg atcaacccta acagtggtgg cacaaactat      180

gcacagaagt ttcagggcag ggtcaccatg accagggaca cgtccatcag cacagcctac      240

atggagctga gcaggctgag atctgacgac acggccgtgt attactgtgc gagagtcccc      300

tattgtagta gtaccagctg ccatcgggac tggtacttcg atctctgggg ccgtggcacc      360

ctggtcactg tctcctca                                                    378


<210>  30
<211>  339
<212>  DNA
<213>  Homo sapiens


<220>
<221>  P2A-1A10 VLnu
<222>  (1)..(339)

<400>  30
gatattgtga tgacccagac tccactctcc ctgcccgtca cccctggaga gccggcctcc       60

atctcctgca ggtctagtca gagcctcttg gatagtgatg atggaaacac ctatttggac      120

tggtacctgc agaagccagg gcagtctcca cagctcctga tctatacgct ttcctatcgg      180

gcctctggag tcccagacag gttcagtggc agtgggtcag gcactgattt cacactgaaa      240

atcagcaggg tggaggctga ggatgttgga gtttattact gcatgcaacg tatagagttt      300

ccgctcactt tcggcggagg gaccaaggtg gagatcaaa                             339


<210>  31
<211>  8
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P2A-1B3 HCDR1
<222>  (1)..(8)

<400>  31

Gly Phe Ser Phe Asn Arg Tyr Ser 
1               5               


<210>  32
<211>  8
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P2A-1B3 HCDR2
<222>  (1)..(8)

<400>  32

Ile Ser Ala Ser Gly Asn Thr Ile 
1               5               


<210>  33
<211>  16
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P2A-1B3 HCDR3
<222>  (1)..(16)

<400>  33

Ala Arg Pro Ala Met Val Arg Glu Gly Thr Tyr Asn Trp Phe Asp Pro 
1               5                   10                  15      


<210>  34
<211>  7
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P2A-1B3 LCDR1
<222>  (1)..(7)

<400>  34

Gln Ser Val Ser Asn Asp Tyr 
1               5           


<210>  35
<211>  4
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P2A-1B3 LCDR2
<222>  (1)..(3)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa is absent.

<400>  35

Tyr Ala Ser Xaa 
1               


<210>  36
<211>  10
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P2A-1B3 LCDR3
<222>  (1)..(10)

<400>  36

Gln Gln Tyr Gly Asp Ser Pro Pro Ile Thr 
1               5                   10  


<210>  37
<211>  123
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P2A-1B3 VH
<222>  (1)..(123)

<400>  37

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Ser Phe Asn Arg Tyr 
            20                  25                  30          


Ser Met Asn Trp Leu Arg Gln Thr Pro Arg Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Ser Tyr Ile Ser Ala Ser Gly Asn Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Arg Gly Arg Phe Thr Thr Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Asp Asp Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Pro Ala Met Val Arg Glu Gly Thr Tyr Asn Trp Phe Asp Pro 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  38
<211>  109
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P2A-1B3 VL
<222>  (1)..(109)

<400>  38

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Asn Asp 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Tyr Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Gly Asp Ser Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Asp Ser Pro 
                85                  90                  95      


Pro Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
            100                 105                 


<210>  39
<211>  369
<212>  DNA
<213>  Homo sapiens


<220>
<221>  P2A-1B3 VHnu
<222>  (1)..(369)

<400>  39
gaggtgcagc tggtggagtc tgggggaggc ttggtacagc ctggggggtc cctcagactc       60

tcctgtgtcg cctctggatt ctccttcaat cgatatagta tgaattggct ccgccagact      120

ccacggaagg ggctggagtg gctttcatac atcagtgcca gtggaaacac catatactac      180

gctgactctg tgaggggccg attcaccacc tccagagaca atgccaagaa cacactgtat      240

ctgcaaatga acagcctgcg agacgacgac acggctgtct atttctgtgc gcgacccgct      300

atggttcggg aggggaccta caactggttc gacccctggg gccagggaac cctggtcacc      360

gtctcctca                                                              369


<210>  40
<211>  327
<212>  DNA
<213>  Homo sapiens


<220>
<221>  P2A-1B3 VLnu
<222>  (1)..(327)

<400>  40
gaaattgtgt tgacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc       60

ctctcctgca gggccagtca gagtgttagc aacgactact tagcctggta ccagcagaaa      120

cctggccagg ctcccaggct cctcatctac tatgcatcca gcagggccac tggcatccca      180

gacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagactggag      240

cctggagatt ctgcagtgta ttactgtcag cagtatggtg actcacctcc gatcaccttc      300

ggccaaggga cacgactgga gattaaa                                          327


<210>  41
<211>  9
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P2B-2F6 HCDR1
<222>  (1)..(9)

<400>  41

Gly Tyr Ser Ile Ser Ser Gly Tyr Tyr 
1               5                   


<210>  42
<211>  7
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P2B-2F6 HCDR2
<222>  (1)..(7)

<400>  42

Ile Tyr His Ser Gly Ser Thr 
1               5           


<210>  43
<211>  20
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P2B-2F6 HCDR3
<222>  (1)..(20)

<400>  43

Ala Arg Ala Val Val Gly Ile Val Val Val Pro Ala Ala Gly Arg Arg 
1               5                   10                  15      


Ala Phe Asp Ile 
            20  


<210>  44
<211>  9
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P2B-2F6 LCDR1
<222>  (1)..(9)

<400>  44

Ser Ser Asp Val Gly Gly Tyr Asn Tyr 
1               5                   


<210>  45
<211>  4
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P2B-2F6 LCDR2
<222>  (1)..(3)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa is absent.

<400>  45

Glu Val Ser Xaa 
1               


<210>  46
<211>  10
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P2B-2F6 LCDR3
<222>  (1)..(10)

<400>  46

Ser Ser Tyr Ala Gly Ser Asn Asn Leu Val 
1               5                   10  


<210>  47
<211>  127
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P2B-2F6 VH
<222>  (1)..(127)

<400>  47

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Tyr Ser Ile Ser Ser Gly 
            20                  25                  30          


Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Ser Ile Tyr His Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Thr Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Val Val Gly Ile Val Val Val Pro Ala Ala Gly Arg Arg 
            100                 105                 110         


Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120                 125         


<210>  48
<211>  110
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P2B-2F6 VL
<222>  (1)..(110)

<400>  48

Gln Ser Ala Leu Thr Gln Pro Pro Ser Ala Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Glu Val Ser Lys Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Val Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Ala Gly Ser 
                85                  90                  95      


Asn Asn Leu Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  49
<211>  381
<212>  DNA
<213>  Homo sapiens


<220>
<221>  P2B-2F6 VHnu
<222>  (1)..(381)

<400>  49
caggtgcagc tgcaggagtc gggcccagga ctggtgaagc cttcggagac cctgtccctc       60

acctgcactg tctctggtta ctccatcagc agtggttact actggggctg gatccggcag      120

cccccaggga aggggctgga gtggattggg agtatctatc atagtgggag cacctactac      180

aacccgtccc tcaagactcg agtcaccata tcagtagaca cgtccaagaa ccagttctcc      240

ctgaagctga gctctgtgac cgccgcagac acggccgtct attactgtgc gagagcggtg      300

gtagggattg tagtagtacc agctgccggt cgtcgggctt ttgatatctg gggccaaggg      360

acaatggtca ccgtctcctc a                                                381


<210>  50
<211>  330
<212>  DNA
<213>  Homo sapiens


<220>
<221>  P2B-2F6 VLnu
<222>  (1)..(330)

<400>  50
cagtctgccc tgactcagcc tccctccgcg tccgggtctc ctggacagtc agtcaccatc       60

tcctgcactg gaaccagcag tgacgttggt ggttataact atgtctcctg gtaccaacag      120

cacccaggca aagcccccaa actcatgatt tatgaggtca gtaagcggcc ctcaggggtc      180

cctgatcgct tctctggctc caagtctggc aacacggcct ccctgaccgt ctctgggctc      240

caggctgagg atgaggctga ttattactgc agctcatatg caggcagcaa caatttggtg      300

ttcggcggag ggaccaagct gaccgtccta                                       330


<210>  51
<211>  8
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P2B-2G4 HCDR1
<222>  (1)..(8)

<400>  51

Gly Phe Thr Phe Ser Ser Tyr Gly 
1               5               


<210>  52
<211>  8
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P2B-2G4 HCDR2
<222>  (1)..(8)

<400>  52

Ile Trp Tyr Asp Gly Ser Asn Lys 
1               5               


<210>  53
<211>  11
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P2B-2G4 HCDR3
<222>  (1)..(11)

<400>  53

Ala Arg Gly Ala Ala Met Val Trp Leu Asp Tyr 
1               5                   10      


<210>  54
<211>  9
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P2B-2G4 LCDR1
<222>  (1)..(9)

<400>  54

Ser Ser Asp Val Gly Gly Tyr Asn Tyr 
1               5                   


<210>  55
<211>  4
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P2B-2G4 LCDR2
<222>  (1)..(3)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa is absent.

<400>  55

Asp Val Ser Xaa 
1               


<210>  56
<211>  11
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P2B-2G4 LCDR3
<222>  (1)..(11)

<400>  56

Cys Ser Tyr Ala Gly Ser Tyr Thr Phe Val Val 
1               5                   10      


<210>  57
<211>  118
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P2B-2G4 VH
<222>  (1)..(118)

<400>  57

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Trp Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ala Ala Met Val Trp Leu Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  58
<211>  111
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P2B-2G4 VL
<222>  (1)..(111)

<400>  58

Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Asp Val Ser Lys Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Cys Ser Tyr Ala Gly Ser 
                85                  90                  95      


Tyr Thr Phe Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110     


<210>  59
<211>  354
<212>  DNA
<213>  Homo sapiens


<220>
<221>  P2B-2G4 VHnu
<222>  (1)..(354)

<400>  59
caggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc       60

tcctgtgcag cgtctggatt caccttcagt agctatggca tgcactgggt ccgccaggct      120

ccaggcaagg ggctggagtg ggtggcagtt atatggtatg atggaagtaa taaatactat      180

gcagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agccgaggac acggctgtgt attactgtgc gagaggggca      300

gctatggttt ggcttgacta ctggggccag ggaaccctgg tcaccgtctc ctca            354


<210>  60
<211>  333
<212>  DNA
<213>  Homo sapiens


<220>
<221>  P2B-2G4 VLnu
<222>  (1)..(333)

<400>  60
cagtctgccc tgactcagcc tcgctcagtg tccgggtctc ctggacagtc agtcaccatc       60

tcctgcactg gaaccagcag tgatgttggt ggttataact atgtctcctg gtaccaacag      120

cacccaggca aagcccccaa actcatgatt tatgatgtca gtaagcggcc ctcaggggtc      180

cctgatcgct tctctggctc caagtctggc aacacggcct ccctgaccat ctctgggctc      240

caggctgagg atgaggctga ttattactgc tgctcatatg caggcagcta cactttcgtg      300

gtattcggcg gagggaccaa gctgaccgtc cta                                   333


<210>  61
<211>  124
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P2B-2G11 VH
<222>  (1)..(124)

<400>  61

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Gly Gly Ile Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Val Ala Gly Arg Gly Asp Tyr Asp Tyr Tyr Tyr Gly Met Asp 
            100                 105                 110         


Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 


<210>  62
<211>  111
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P2B-2G11 VL
<222>  (1)..(111)

<400>  62

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gly Asn Asn Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 
                85                  90                  95      


Leu Ser Gly Ser Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110     


<210>  63
<211>  372
<212>  DNA
<213>  Homo sapiens


<220>
<221>  P2B-2G11 VHnu
<222>  (1)..(372)

<400>  63
gaagtgcagc tggtggagtc tgggggaggc ttggtacagc ctggcaggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgat gattatgcca tgcactgggt ccggcaagct      120

ccagggaagg gcctggagtg ggtctcaggt attagttgga atggtggtat cataggctat      180

gcggactctg tgaagggccg attcaccatc tccagagaca acgccaagac ttccctgtat      240

ctgcaaatga acagtctgaa acctgaggac acggccttgt attactgtgc aaaagtcgcg      300

ggaagggggg attacgacta ctactacggt atggacgtct ggggccaagg gaccacggtc      360

accgtctcct ca                                                          372


<210>  64
<211>  333
<212>  DNA
<213>  Homo sapiens


<220>
<221>  P2B-2G11 VLnu
<222>  (1)..(333)

<400>  64
cagtctgtgc tgacgcagcc gccctcagtg tctggggccc cagggcagag ggtcaccatc       60

tcctgcactg ggagcagctc caacatcggg gcaggttatg atgtacactg gtaccagcaa      120

cttccaggaa cagcccccaa actcctcatc tatgggaaca acaatcggcc ctcaggggtc      180

cctgaccgat tctctggctc caagtctggc acctcagcct ccctggccat cactgggctc      240

caggctgagg atgaggctga ttattactgc cagtcctatg acagcagcct gagtggttcg      300

gtattcggcg gagggaccaa gctgaccgtc cta                                   333


<210>  65
<211>  8
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P2C-1A3 HCDR1
<222>  (1)..(8)

<400>  65

Gly Phe Thr Phe Ser Asp Tyr Tyr 
1               5               


<210>  66
<211>  8
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P2C-1A3 HCDR2
<222>  (1)..(8)

<400>  66

Ile Ser Ser Ser Gly Ser Thr Ile 
1               5               


<210>  67
<211>  12
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P2C-1A3 HCDR3
<222>  (1)..(12)

<400>  67

Ala Arg Asp Phe Ser His Gln Gln Leu Val Pro Ser 
1               5                   10          


<210>  68
<211>  6
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P2C-1A3 LCDR1
<222>  (1)..(6)

<400>  68

Gln Gly Ile Ser Ser Tyr 
1               5       


<210>  69
<211>  4
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P2C-1A3 LCDR2
<222>  (1)..(3)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa is absent.

<400>  69

Ala Ala Ser Xaa 
1               


<210>  70
<211>  9
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P2C-1A3 LCDR3
<222>  (1)..(9)

<400>  70

Gln Gln Leu Asn Ser Tyr Pro Leu Thr 
1               5                   


<210>  71
<211>  119
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P2C-1A3 VH
<222>  (1)..(119)

<400>  71

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Phe Ser His Gln Gln Leu Val Pro Ser Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  72
<211>  107
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P2C-1A3 VL
<222>  (1)..(107)

<400>  72

Asp Ile Gln Leu Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Leu Asn Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  73
<211>  357
<212>  DNA
<213>  Homo sapiens


<220>
<221>  P2C-1A3 VHnu
<222>  (1)..(357)

<400>  73
caggtgcagc tggtggagtc tgggggaggc ttggtcaagc ctggagggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt gactactaca tgagctggat ccgccaggct      120

ccagggaagg ggctggagtg ggtttcatac attagtagta gtggtagtac catatactac      180

gcagactctg tgaagggccg attcaccatc tccagggaca acgccaagaa ctcactgtat      240

ctgcaaatga acagcctgag agccgaggac acggctgtgt attactgtgc gagagatttt      300

tctcatcagc agctggtacc ttcctggggc cagggaaccc tggtcaccgt ctcctca         357


<210>  74
<211>  321
<212>  DNA
<213>  Homo sapiens


<220>
<221>  P2C-1A3 VLnu
<222>  (1)..(321)

<400>  74
gacatccagt tgacccagtc tccatccttc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggccagtca gggcattagc agttatttag cctggtatca gcaaaaacca      120

gggaaagccc ctaagctcct gatctatgct gcatccactt tgcaaagtgg ggtcccatca      180

aggttcagcg gcagtggatc tgggacagaa ttcactctca caatcagcag cctgcagcct      240

gaagattttg caacttatta ctgtcaacag cttaatagtt acccgctcac tttcggcgga      300

gggaccaagg tggagatcaa a                                                321


<210>  75
<211>  8
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P2C-1C8 HCDR1
<222>  (1)..(8)

<400>  75

Gly Phe Thr Phe Arg Ser Tyr Gly 
1               5               


<210>  76
<211>  8
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P2C-1C8 HCDR2
<222>  (1)..(8)

<400>  76

Ile Trp Tyr Asp Gly Ser Asn Lys 
1               5               


<210>  77
<211>  13
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P2C-1C8 HCDR3
<222>  (1)..(13)

<400>  77

Ala Arg Asp Ile Glu Ile Val Val Val Asn Ile Asp Tyr 
1               5                   10              


<210>  78
<211>  11
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P2C-1C8 LCDR1
<222>  (1)..(11)

<400>  78

Gln Ser Leu Val Tyr Ser Asp Gly Asn Thr Tyr 
1               5                   10      


<210>  79
<211>  4
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P2C-1C8 LCDR2
<222>  (1)..(3)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa is absent.

<400>  79

Lys Val Ser Xaa 
1               


<210>  80
<211>  9
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P2C-1C8 LCDR3
<222>  (1)..(9)

<400>  80

Met Gln Gly Thr His Trp Pro Tyr Thr 
1               5                   


<210>  81
<211>  120
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P2C-1C8 VH
<222>  (1)..(120)

<400>  81

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Trp Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Ile Glu Ile Val Val Val Asn Ile Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  82
<211>  112
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P2C-1C8 VL
<222>  (1)..(112)

<400>  82

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val Tyr Ser 
            20                  25                  30          


Asp Gly Asn Thr Tyr Leu Asn Trp Phe Gln Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Arg Leu Ile Tyr Lys Val Ser Ile Trp Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Gly 
                85                  90                  95      


Thr His Trp Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  83
<211>  360
<212>  DNA
<213>  Homo sapiens


<220>
<221>  P2C-1C8 VHnu
<222>  (1)..(360)

<400>  83
caggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc       60

tcctgtgcag cgtctggatt caccttcagg agctatggca tgcactgggt ccgccaggct      120

ccaggcaagg ggctggagtg ggtggcagtt atctggtatg atggaagtaa taaatactat      180

gcagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agccgaggac acggctgtgt attactgtgc gagagatata      300

gagatagtag tggtaaatat tgactactgg ggccagggaa ccctggtcac cgtctcctca      360


<210>  84
<211>  336
<212>  DNA
<213>  Homo sapiens


<220>
<221>  P2C-1C8 VLnu
<222>  (1)..(336)

<400>  84
gatgttgtga tgactcagtc tccactctcc ctgcccgtca cccttggaca gccggcctcc       60

atctcctgca ggtctagtca aagcctcgta tacagtgatg gaaacaccta cttgaattgg      120

tttcagcaga ggccaggcca atctccaagg cgcctaattt ataaggtttc tatctgggac      180

tctggggtcc cagacagatt cagcggcagt gggtcaggca ctgatttcac actgaaaatc      240

agcagggtgg aggctgagga tgttggggtt tattactgca tgcaaggtac acactggccg      300

tacacttttg gccaggggac caagctggag atcaaa                                336


<210>  85
<211>  8
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P2C-1C10 HCDR1
<222>  (1)..(8)

<400>  85

Gly Gly Thr Phe Ser Ser Tyr Ala 
1               5               


<210>  86
<211>  8
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P2C-1C10 HCDR2
<222>  (1)..(8)

<400>  86

Ile Ile Pro Ile Phe Gly Thr Ala 
1               5               


<210>  87
<211>  11
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P2C-1C10 HCDR3
<222>  (1)..(11)

<400>  87

Ala Arg Val Val Thr Gly Tyr Tyr Phe Asp Tyr 
1               5                   10      


<210>  88
<211>  6
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P2C-1C10 LCDR1
<222>  (1)..(6)

<400>  88

Gln Ser Val Ser Ser Tyr 
1               5       


<210>  89
<211>  4
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P2C-1C10 LCDR2
<222>  (1)..(3)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa is absent.

<400>  89

Asp Ala Ser Xaa 
1               


<210>  90
<211>  8
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P2C-1C10 LCDR3
<222>  (1)..(8)

<400>  90

Gln Gln Arg Ser Asn Trp Pro Ser 
1               5               


<210>  91
<211>  118
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P2C-1C10 VH
<222>  (1)..(118)

<400>  91

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ile Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Val Val Thr Gly Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  92
<211>  106
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P2C-1C10 VL
<222>  (1)..(106)

<400>  92

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Ser 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  93
<211>  354
<212>  DNA
<213>  Homo sapiens


<220>
<221>  P2C-1C10 VHnu
<222>  (1)..(354)

<400>  93
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cttctggagg caccttcagc agctatgcta tcatctgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggaggg atcatcccta tctttggtac agcaaactac      180

gcacagaagt tccagggcag agtcacgatt accgcggacg aatccacgag cacagcctac      240

atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gagagtggta      300

acggggtact actttgacta ctggggccag ggaaccctgg tcaccgtctc ctca            354


<210>  94
<211>  318
<212>  DNA
<213>  Homo sapiens


<220>
<221>  P2C-1C10 VLnu
<222>  (1)..(318)

<400>  94
gaaattgtgt tgacacagtc tccagccacc ctgtctttgt ctccagggga aagagccacc       60

ctctcctgca gggccagtca gagtgttagc agctacttag cctggtacca acagaaacct      120

ggccaggctc ccaggctcct catctatgat gcatccaaca gggccactgg catcccagcc      180

aggttcagtg gcagtgggtc tgggacagac ttcactctca ccatcagcag cctagagcct      240

gaagattttg cagtttatta ctgtcagcag cgtagcaact ggccttcttt tggccagggg      300

accaagctgg agatcaaa                                                    318


<210>  95
<211>  8
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P2C-1D5 HCDR1
<222>  (1)..(8)

<400>  95

Gly Phe Thr Phe Ser Ser Phe Ala 
1               5               


<210>  96
<211>  8
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P2C-1D5 HCDR2
<222>  (1)..(8)

<400>  96

Ile Ser Gly Ser Gly Gly Ser Thr 
1               5               


<210>  97
<211>  14
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P2C-1D5 HCDR3
<222>  (1)..(14)

<400>  97

Ala Lys Asp Pro Asp Gly Ser Gly Ser Trp Tyr Phe Asp Tyr 
1               5                   10                  


<210>  98
<211>  6
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P2C-1D5 LCDR1
<222>  (1)..(6)

<400>  98

Asn Ile Gly Ser Lys Ser 
1               5       


<210>  99
<211>  4
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P2C-1D5 LCDR2
<222>  (1)..(3)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa is absent.

<400>  99

Tyr Asp Ser Xaa 
1               


<210>  100
<211>  11
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P2C-1D5 LCDR3
<222>  (1)..(11)

<400>  100

Gln Val Trp Asp Ser Ser Ser Asp His His Val 
1               5                   10      


<210>  101
<211>  121
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P2C-1D5 VH
<222>  (1)..(121)

<400>  101

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Pro Asp Gly Ser Gly Ser Trp Tyr Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  102
<211>  108
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P2C-1D5 VL
<222>  (1)..(108)

<400>  102

Ser Tyr Val Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Lys 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly Ser Lys Ser Val 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Tyr Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala Gly 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Ser Ser Ser Asp His 
                85                  90                  95      


His Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu 
            100                 105             


<210>  103
<211>  363
<212>  DNA
<213>  Homo sapiens


<220>
<221>  P2C-1D5 VHnu
<222>  (1)..(363)

<400>  103
gaggtgcagc tggtggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttagc agctttgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcagct attagtggta gtggtggtag cacatactac      180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat      240

ttgcaaatga acagcctgag agccgaggac acggccgtat attactgtgc gaaagatccg      300

gatggttcgg ggagttggta ctttgactac tggggccagg gaaccctggt caccgtctcc      360

tca                                                                    363


<210>  104
<211>  324
<212>  DNA
<213>  Homo sapiens


<220>
<221>  P2C-1D5 VLnu
<222>  (1)..(324)

<400>  104
tcctatgtgc tgactcagcc accctcagtg tcagtggccc caggaaagac ggccaggatt       60

acctgtgggg gaaacaacat tggaagtaaa agtgtgcact ggtaccagca gaagccaggc      120

caggcccctg tgctggtcat ctattatgat agcgaccggc cctcagggat ccctgagcga      180

ttctctggct ccaactctgg gaacaccgcc accctgacca tcagcagggt cgaagccggg      240

gatgaggccg actattactg tcaggtgtgg gatagtagta gtgatcatca tgtcttcgga      300

actgggacca aggtcaccgt ccta                                             324


<210>  105
<211>  8
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P2C-1F11 HCDR1
<222>  (1)..(8)

<400>  105

Gly Ile Thr Val Ser Ser Asn Tyr 
1               5               


<210>  106
<211>  7
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P2C-1F11 HCDR2
<222>  (1)..(7)

<400>  106

Ile Tyr Ser Gly Gly Ser Thr 
1               5           


<210>  107
<211>  11
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P2C-1F11 HCDR3
<222>  (1)..(11)

<400>  107

Ala Arg Asp Leu Val Val Tyr Gly Met Asp Val 
1               5                   10      


<210>  108
<211>  7
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P2C-1F11 LCDR1
<222>  (1)..(7)

<400>  108

Gln Ser Val Ser Ser Ser Tyr 
1               5           


<210>  109
<211>  4
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P2C-1F11 LCDR2
<222>  (1)..(3)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa is absent.

<400>  109

Gly Ala Ser Xaa 
1               


<210>  110
<211>  8
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P2C-1F11 LCDR3
<222>  (1)..(8)

<400>  110

Gln Gln Tyr Gly Ser Ser Pro Thr 
1               5               


<210>  111
<211>  117
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P2C-1F11 VH
<222>  (1)..(117)

<400>  111

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ile Thr Val Ser Ser Asn 
            20                  25                  30          


Tyr Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Leu Ile Tyr Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr His Cys Ala 
                85                  90                  95      


Arg Asp Leu Val Val Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  112
<211>  107
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P2C-1F11 VL
<222>  (1)..(107)

<400>  112

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  113
<211>  351
<212>  DNA
<213>  Homo sapiens


<220>
<221>  P2C-1F11 VHnu
<222>  (1)..(351)

<400>  113
gaggtgcagc tggtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggaat caccgtcagt agcaactaca tgaactgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcactt atttatagcg gtggtagcac atactacgca      180

gactccgtga agggcagatt caccatctcc agagacaatt ccaagaacac gttgtatctt      240

caaatgaaca gcctgagagc cgaggacacg gctgtgtatc actgtgcgag agatctggtg      300

gtatacggta tggacgtctg gggccaaggg accacggtca ccgtctcctc a               351


<210>  114
<211>  321
<212>  DNA
<213>  Homo sapiens


<220>
<221>  P2C-1F11 VLnu
<222>  (1)..(321)

<400>  114
gaaattgtgt tgacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc       60

ctctcctgca gggccagtca gagtgttagc agcagctact tagcctggta ccagcagaaa      120

cctggccagg ctcccaggct cctcatctat ggtgcatcca gcagggccac tggcatccca      180

gacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagactggag      240

cctgaagatt ttgcagtgta ttactgtcag cagtatggta gctcacccac ttttggccag      300

gggaccaagc tggagatcaa a                                                321


<210>  115
<211>  330
<212>  PRT
<213>  Homo sapiens


<220>
<221>  Amino acid sequence of heavy chain constant region
<222>  (1)..(330)

<400>  115

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  116
<211>  106
<212>  PRT
<213>  Homo sapiens


<220>
<221>  Amino acid sequence of lambda light chain constant region
<222>  (1)..(106)

<400>  116

Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser 
1               5                   10                  15      


Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp 
            20                  25                  30          


Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro 
        35                  40                  45              


Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn 
    50                  55                  60                  


Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
65                  70                  75                  80  


Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val 
                85                  90                  95      


Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
            100                 105     


<210>  117
<211>  107
<212>  PRT
<213>  Homo sapiens


<220>
<221>  Amino acid sequence of appa light chain constant region
<222>  (1)..(107)

<400>  117

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


<210>  118
<211>  990
<212>  DNA
<213>  Homo sapiens


<220>
<221>  Nucleic acid sequence of heavy chain constant region
<222>  (1)..(990)

<400>  118
gcgtcgacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg       60

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaacccgt gacggtgtcg      120

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      240

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagaa agttgagccc      300

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga      360

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      420

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      480

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac      540

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      600

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc      660

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggatgag      720

ctgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc      780

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg      840

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg      900

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg      960

cagaagagcc tctccctgtc tccgggtaaa                                       990


<210>  119
<211>  318
<212>  DNA
<213>  Homo sapiens


<220>
<221>  Nucleic acid sequence of lambda light chain constant region
<222>  (1)..(318)

<400>  119
ggtcagccca aggctgcccc ctcggtcact ctgttcccac cctcgagtga ggagcttcaa       60

gccaacaagg ccacactggt gtgtctcata agtgacttct acccgggagc cgtgacagtg      120

gcctggaagg cagatagcag ccccgtcaag gcgggagtgg agaccaccac accctccaaa      180

caaagcaaca acaagtacgc ggccagcagc tacctgagcc tgacgcctga gcagtggaag      240

tcccacagaa gctacagctg ccaggtcacg catgaaggga gcaccgtgga gaagacagtg      300

gcccctacag aatgttca                                                    318


<210>  120
<211>  321
<212>  DNA
<213>  Homo sapiens


<220>
<221>  Nucleic acid sequence of kappa light chain constant region
<222>  (1)..(321)

<400>  120
cgtacggtgg ctgcaccatc tgtcttcatc ttcccgccat ctgatgagca gttgaaatct       60

ggaactgcct ctgttgtgtg cctgctgaat aacttctacc ccagagaagc caaagtgcag      120

tggaaggtgg acaacgccct gcagagcgga aacagccagg aaagcgtgac agagcaggat      180

tccaaggatt ccacatacag cctgagcagc acactgacac tgtccaaggc cgactacgag      240

aagcacaagg tgtacgcctg cgaagtgaca caccagggac tgtcctcccc tgtgacaaag      300

agcttcaaca gaggagaatg c                                                321


<210>  121
<211>  1211
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the extracellular domain of S protein of 
       SARS-CoV-2

<400>  121

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
                245                 250                 255     


Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270         


Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285             


Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                 


Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
305                 310                 315                 320 


Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 
                325                 330                 335     


Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 
            340                 345                 350         


Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
        355                 360                 365             


Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
    370                 375                 380                 


Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
385                 390                 395                 400 


Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
                405                 410                 415     


Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
            420                 425                 430         


Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
        435                 440                 445             


Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
    450                 455                 460                 


Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
465                 470                 475                 480 


Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
                485                 490                 495     


Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
            500                 505                 510         


Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
        515                 520                 525             


Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
    530                 535                 540                 


Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
545                 550                 555                 560 


Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 
                565                 570                 575     


Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 
            580                 585                 590         


Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 
        595                 600                 605             


Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile 
    610                 615                 620                 


His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 
625                 630                 635                 640 


Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val 
                645                 650                 655     


Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 
            660                 665                 670         


Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala 
        675                 680                 685             


Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser 
    690                 695                 700                 


Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile 
705                 710                 715                 720 


Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 
                725                 730                 735     


Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu 
            740                 745                 750         


Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr 
        755                 760                 765             


Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln 
    770                 775                 780                 


Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe 
785                 790                 795                 800 


Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser 
                805                 810                 815     


Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly 
            820                 825                 830         


Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp 
        835                 840                 845             


Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu 
    850                 855                 860                 


Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly 
865                 870                 875                 880 


Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile 
                885                 890                 895     


Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr 
            900                 905                 910         


Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn 
        915                 920                 925             


Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala 
    930                 935                 940                 


Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn 
945                 950                 955                 960 


Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val 
                965                 970                 975     


Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln 
            980                 985                 990         


Ile Asp Arg Leu Ile Thr Gly Arg  Leu Gln Ser Leu Gln  Thr Tyr Val 
        995                 1000                 1005             


Thr Gln  Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
    1010                 1015                 1020             


Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1025                 1030                 1035             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1040                 1045                 1050             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1055                 1060                 1065             


Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1070                 1075                 1080             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1085                 1090                 1095             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1100                 1105                 1110             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1115                 1120                 1125             


Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro 
    1130                 1135                 1140             


Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Tyr  Phe Lys Asn 
    1145                 1150                 1155             


His Thr  Ser Pro Asp Val Asp  Leu Gly Asp Ile Ser  Gly Ile Asn 
    1160                 1165                 1170             


Ala Ser  Val Val Asn Ile Gln  Lys Glu Ile Asp Arg  Leu Asn Glu 
    1175                 1180                 1185             


Val Ala  Lys Asn Leu Asn Glu  Ser Leu Ile Asp Leu  Gln Glu Leu 
    1190                 1195                 1200             


Gly Lys  Tyr Glu Gln Tyr Ile  Lys 
    1205                 1210     


<210>  122
<211>  1195
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the extracellular domain of S protein of 
       SARS-CoV

<400>  122

Met Phe Ile Phe Leu Leu Phe Leu Thr Leu Thr Ser Gly Ser Asp Leu 
1               5                   10                  15      


Asp Arg Cys Thr Thr Phe Asp Asp Val Gln Ala Pro Asn Tyr Thr Gln 
            20                  25                  30          


His Thr Ser Ser Met Arg Gly Val Tyr Tyr Pro Asp Glu Ile Phe Arg 
        35                  40                  45              


Ser Asp Thr Leu Tyr Leu Thr Gln Asp Leu Phe Leu Pro Phe Tyr Ser 
    50                  55                  60                  


Asn Val Thr Gly Phe His Thr Ile Asn His Thr Phe Gly Asn Pro Val 
65                  70                  75                  80  


Ile Pro Phe Lys Asp Gly Ile Tyr Phe Ala Ala Thr Glu Lys Ser Asn 
                85                  90                  95      


Val Val Arg Gly Trp Val Phe Gly Ser Thr Met Asn Asn Lys Ser Gln 
            100                 105                 110         


Ser Val Ile Ile Ile Asn Asn Ser Thr Asn Val Val Ile Arg Ala Cys 
        115                 120                 125             


Asn Phe Glu Leu Cys Asp Asn Pro Phe Phe Ala Val Ser Lys Pro Met 
    130                 135                 140                 


Gly Thr Gln Thr His Thr Met Ile Phe Asp Asn Ala Phe Asn Cys Thr 
145                 150                 155                 160 


Phe Glu Tyr Ile Ser Asp Ala Phe Ser Leu Asp Val Ser Glu Lys Ser 
                165                 170                 175     


Gly Asn Phe Lys His Leu Arg Glu Phe Val Phe Lys Asn Lys Asp Gly 
            180                 185                 190         


Phe Leu Tyr Val Tyr Lys Gly Tyr Gln Pro Ile Asp Val Val Arg Asp 
        195                 200                 205             


Leu Pro Ser Gly Phe Asn Thr Leu Lys Pro Ile Phe Lys Leu Pro Leu 
    210                 215                 220                 


Gly Ile Asn Ile Thr Asn Phe Arg Ala Ile Leu Thr Ala Phe Ser Pro 
225                 230                 235                 240 


Ala Gln Asp Ile Trp Gly Thr Ser Ala Ala Ala Tyr Phe Val Gly Tyr 
                245                 250                 255     


Leu Lys Pro Thr Thr Phe Met Leu Lys Tyr Asp Glu Asn Gly Thr Ile 
            260                 265                 270         


Thr Asp Ala Val Asp Cys Ser Gln Asn Pro Leu Ala Glu Leu Lys Cys 
        275                 280                 285             


Ser Val Lys Ser Phe Glu Ile Asp Lys Gly Ile Tyr Gln Thr Ser Asn 
    290                 295                 300                 


Phe Arg Val Val Pro Ser Gly Asp Val Val Arg Phe Pro Asn Ile Thr 
305                 310                 315                 320 


Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Lys Phe Pro Ser 
                325                 330                 335     


Val Tyr Ala Trp Glu Arg Lys Lys Ile Ser Asn Cys Val Ala Asp Tyr 
            340                 345                 350         


Ser Val Leu Tyr Asn Ser Thr Phe Phe Ser Thr Phe Lys Cys Tyr Gly 
        355                 360                 365             


Val Ser Ala Thr Lys Leu Asn Asp Leu Cys Phe Ser Asn Val Tyr Ala 
    370                 375                 380                 


Asp Ser Phe Val Val Lys Gly Asp Asp Val Arg Gln Ile Ala Pro Gly 
385                 390                 395                 400 


Gln Thr Gly Val Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe 
                405                 410                 415     


Met Gly Cys Val Leu Ala Trp Asn Thr Arg Asn Ile Asp Ala Thr Ser 
            420                 425                 430         


Thr Gly Asn Tyr Asn Tyr Lys Tyr Arg Tyr Leu Arg His Gly Lys Leu 
        435                 440                 445             


Arg Pro Phe Glu Arg Asp Ile Ser Asn Val Pro Phe Ser Pro Asp Gly 
    450                 455                 460                 


Lys Pro Cys Thr Pro Pro Ala Leu Asn Cys Tyr Trp Pro Leu Asn Asp 
465                 470                 475                 480 


Tyr Gly Phe Tyr Thr Thr Thr Gly Ile Gly Tyr Gln Pro Tyr Arg Val 
                485                 490                 495     


Val Val Leu Ser Phe Glu Leu Leu Asn Ala Pro Ala Thr Val Cys Gly 
            500                 505                 510         


Pro Lys Leu Ser Thr Asp Leu Ile Lys Asn Gln Cys Val Asn Phe Asn 
        515                 520                 525             


Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Pro Ser Ser Lys Arg 
    530                 535                 540                 


Phe Gln Pro Phe Gln Gln Phe Gly Arg Asp Val Ser Asp Phe Thr Asp 
545                 550                 555                 560 


Ser Val Arg Asp Pro Lys Thr Ser Glu Ile Leu Asp Ile Ser Pro Cys 
                565                 570                 575     


Ala Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Ala Ser Ser 
            580                 585                 590         


Glu Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Asp Val Ser Thr 
        595                 600                 605             


Ala Ile His Ala Asp Gln Leu Thr Pro Ala Trp Arg Ile Tyr Ser Thr 
    610                 615                 620                 


Gly Asn Asn Val Phe Gln Thr Gln Ala Gly Cys Leu Ile Gly Ala Glu 
625                 630                 635                 640 


His Val Asp Thr Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile 
                645                 650                 655     


Cys Ala Ser Tyr His Thr Val Ser Leu Leu Arg Ser Thr Ser Gln Lys 
            660                 665                 670         


Ser Ile Val Ala Tyr Thr Met Ser Leu Gly Ala Asp Ser Ser Ile Ala 
        675                 680                 685             


Tyr Ser Asn Asn Thr Ile Ala Ile Pro Thr Asn Phe Ser Ile Ser Ile 
    690                 695                 700                 


Thr Thr Glu Val Met Pro Val Ser Met Ala Lys Thr Ser Val Asp Cys 
705                 710                 715                 720 


Asn Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ala Asn Leu Leu Leu 
                725                 730                 735     


Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Ser Gly Ile 
            740                 745                 750         


Ala Ala Glu Gln Asp Arg Asn Thr Arg Glu Val Phe Ala Gln Val Lys 
        755                 760                 765             


Gln Met Tyr Lys Thr Pro Thr Leu Lys Tyr Phe Gly Gly Phe Asn Phe 
    770                 775                 780                 


Ser Gln Ile Leu Pro Asp Pro Leu Lys Pro Thr Lys Arg Ser Phe Ile 
785                 790                 795                 800 


Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly Phe Met 
                805                 810                 815     


Lys Gln Tyr Gly Glu Cys Leu Gly Asp Ile Asn Ala Arg Asp Leu Ile 
            820                 825                 830         


Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu Leu Thr 
        835                 840                 845             


Asp Asp Met Ile Ala Ala Tyr Thr Ala Ala Leu Val Ser Gly Thr Ala 
    850                 855                 860                 


Thr Ala Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile Pro Phe 
865                 870                 875                 880 


Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr Gln Asn 
                885                 890                 895     


Val Leu Tyr Glu Asn Gln Lys Gln Ile Ala Asn Gln Phe Asn Lys Ala 
            900                 905                 910         


Ile Ser Gln Ile Gln Glu Ser Leu Thr Thr Thr Ser Thr Ala Leu Gly 
        915                 920                 925             


Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn Thr Leu 
    930                 935                 940                 


Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val Leu Asn 
945                 950                 955                 960 


Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln Ile Asp 
                965                 970                 975     


Arg Leu Ile Thr Gly Arg Leu Gln Ser Leu Gln Thr Tyr Val Thr Gln 
            980                 985                 990         


Gln Leu Ile Arg Ala Ala Glu Ile  Arg Ala Ser Ala Asn  Leu Ala Ala 
        995                 1000                 1005             


Thr Lys  Met Ser Glu Cys Val  Leu Gly Gln Ser Lys  Arg Val Asp 
    1010                 1015                 1020             


Phe Cys  Gly Lys Gly Tyr His  Leu Met Ser Phe Pro  Gln Ala Ala 
    1025                 1030                 1035             


Pro His  Gly Val Val Phe Leu  His Val Thr Tyr Val  Pro Ser Gln 
    1040                 1045                 1050             


Glu Arg  Asn Phe Thr Thr Ala  Pro Ala Ile Cys His  Glu Gly Lys 
    1055                 1060                 1065             


Ala Tyr  Phe Pro Arg Glu Gly  Val Phe Val Phe Asn  Gly Thr Ser 
    1070                 1075                 1080             


Trp Phe  Ile Thr Gln Arg Asn  Phe Phe Ser Pro Gln  Ile Ile Thr 
    1085                 1090                 1095             


Thr Asp  Asn Thr Phe Val Ser  Gly Asn Cys Asp Val  Val Ile Gly 
    1100                 1105                 1110             


Ile Ile  Asn Asn Thr Val Tyr  Asp Pro Leu Gln Pro  Glu Leu Asp 
    1115                 1120                 1125             


Ser Phe  Lys Glu Glu Leu Asp  Lys Tyr Phe Lys Asn  His Thr Ser 
    1130                 1135                 1140             


Pro Asp  Val Asp Leu Gly Asp  Ile Ser Gly Ile Asn  Ala Ser Val 
    1145                 1150                 1155             


Val Asn  Ile Gln Lys Glu Ile  Asp Arg Leu Asn Glu  Val Ala Lys 
    1160                 1165                 1170             


Asn Leu  Asn Glu Ser Leu Ile  Asp Leu Gln Glu Leu  Gly Lys Tyr 
    1175                 1180                 1185             


Glu Gln  Tyr Ile Lys Trp Pro  
    1190                 1195 


<210>  123
<211>  1290
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the extracellular domain of S protein of 
       MERS-CoV

<400>  123

Met Ile His Ser Val Phe Leu Leu Met Phe Leu Leu Thr Pro Thr Glu 
1               5                   10                  15      


Ser Tyr Val Asp Val Gly Pro Asp Ser Val Lys Ser Ala Cys Ile Glu 
            20                  25                  30          


Val Asp Ile Gln Gln Thr Phe Phe Asp Lys Thr Trp Pro Arg Pro Ile 
        35                  40                  45              


Asp Val Ser Lys Ala Asp Gly Ile Ile Tyr Pro Gln Gly Arg Thr Tyr 
    50                  55                  60                  


Ser Asn Ile Thr Ile Thr Tyr Gln Gly Leu Phe Pro Tyr Gln Gly Asp 
65                  70                  75                  80  


His Gly Asp Met Tyr Val Tyr Ser Ala Gly His Ala Thr Gly Thr Thr 
                85                  90                  95      


Pro Gln Lys Leu Phe Val Ala Asn Tyr Ser Gln Asp Val Lys Gln Phe 
            100                 105                 110         


Ala Asn Gly Phe Val Val Arg Ile Gly Ala Ala Ala Asn Ser Thr Gly 
        115                 120                 125             


Thr Val Ile Ile Ser Pro Ser Thr Ser Ala Thr Ile Arg Lys Ile Tyr 
    130                 135                 140                 


Pro Ala Phe Met Leu Gly Ser Ser Val Gly Asn Phe Ser Asp Gly Lys 
145                 150                 155                 160 


Met Gly Arg Phe Phe Asn His Thr Leu Val Leu Leu Pro Asp Gly Cys 
                165                 170                 175     


Gly Thr Leu Leu Arg Ala Phe Tyr Cys Ile Leu Glu Pro Arg Ser Gly 
            180                 185                 190         


Asn His Cys Pro Ala Gly Asn Ser Tyr Thr Ser Phe Ala Thr Tyr His 
        195                 200                 205             


Thr Pro Ala Thr Asp Cys Ser Asp Gly Asn Tyr Asn Arg Asn Ala Ser 
    210                 215                 220                 


Leu Asn Ser Phe Lys Glu Tyr Phe Asn Leu Arg Asn Cys Thr Phe Met 
225                 230                 235                 240 


Tyr Thr Tyr Asn Ile Thr Glu Asp Glu Ile Leu Glu Trp Phe Gly Ile 
                245                 250                 255     


Thr Gln Thr Ala Gln Gly Val His Leu Phe Ser Ser Arg Tyr Val Asp 
            260                 265                 270         


Leu Tyr Gly Gly Asn Met Phe Gln Phe Ala Thr Leu Pro Val Tyr Asp 
        275                 280                 285             


Thr Ile Lys Tyr Tyr Ser Ile Ile Pro His Ser Ile Arg Ser Ile Gln 
    290                 295                 300                 


Ser Asp Arg Lys Ala Trp Ala Ala Phe Tyr Val Tyr Lys Leu Gln Pro 
305                 310                 315                 320 


Leu Thr Phe Leu Leu Asp Phe Ser Val Asp Gly Tyr Ile Arg Arg Ala 
                325                 330                 335     


Ile Asp Cys Gly Phe Asn Asp Leu Ser Gln Leu His Cys Ser Tyr Glu 
            340                 345                 350         


Ser Phe Asp Val Glu Ser Gly Val Tyr Ser Val Ser Ser Phe Glu Ala 
        355                 360                 365             


Lys Pro Ser Gly Ser Val Val Glu Gln Ala Glu Gly Val Glu Cys Asp 
    370                 375                 380                 


Phe Ser Pro Leu Leu Ser Gly Thr Pro Pro Gln Val Tyr Asn Phe Lys 
385                 390                 395                 400 


Arg Leu Val Phe Thr Asn Cys Asn Tyr Asn Leu Thr Lys Leu Leu Ser 
                405                 410                 415     


Leu Phe Ser Val Asn Asp Phe Thr Cys Ser Gln Ile Ser Pro Ala Ala 
            420                 425                 430         


Ile Ala Ser Asn Cys Tyr Ser Ser Leu Ile Leu Asp Tyr Phe Ser Tyr 
        435                 440                 445             


Pro Leu Ser Met Lys Ser Asp Leu Ser Val Ser Ser Ala Gly Pro Ile 
    450                 455                 460                 


Ser Gln Phe Asn Tyr Lys Gln Ser Phe Ser Asn Pro Thr Cys Leu Ile 
465                 470                 475                 480 


Leu Ala Thr Val Pro His Asn Leu Thr Thr Ile Thr Lys Pro Leu Lys 
                485                 490                 495     


Tyr Ser Tyr Ile Asn Lys Cys Ser Arg Leu Leu Ser Asp Asp Arg Thr 
            500                 505                 510         


Glu Val Pro Gln Leu Val Asn Ala Asn Gln Tyr Ser Pro Cys Val Ser 
        515                 520                 525             


Ile Val Pro Ser Thr Val Trp Glu Asp Gly Asp Tyr Tyr Arg Lys Gln 
    530                 535                 540                 


Leu Ser Pro Leu Glu Gly Gly Gly Trp Leu Val Ala Ser Gly Ser Thr 
545                 550                 555                 560 


Val Ala Met Thr Glu Gln Leu Gln Met Gly Phe Gly Ile Thr Val Gln 
                565                 570                 575     


Tyr Gly Thr Asp Thr Asn Ser Val Cys Pro Lys Leu Glu Phe Ala Asn 
            580                 585                 590         


Asp Thr Lys Ile Ala Ser Gln Leu Gly Asn Cys Val Glu Tyr Ser Leu 
        595                 600                 605             


Tyr Gly Val Ser Gly Arg Gly Val Phe Gln Asn Cys Thr Ala Val Gly 
    610                 615                 620                 


Val Arg Gln Gln Arg Phe Val Tyr Asp Ala Tyr Gln Asn Leu Val Gly 
625                 630                 635                 640 


Tyr Tyr Ser Asp Asp Gly Asn Tyr Tyr Cys Leu Arg Ala Cys Val Ser 
                645                 650                 655     


Val Pro Val Ser Val Ile Tyr Asp Lys Glu Thr Lys Thr His Ala Thr 
            660                 665                 670         


Leu Phe Gly Ser Val Ala Cys Glu His Ile Ser Ser Thr Met Ser Gln 
        675                 680                 685             


Tyr Ser Arg Ser Thr Arg Ser Met Leu Lys Arg Arg Asp Ser Thr Tyr 
    690                 695                 700                 


Gly Pro Leu Gln Thr Pro Val Gly Cys Val Leu Gly Leu Val Asn Ser 
705                 710                 715                 720 


Ser Leu Phe Val Glu Asp Cys Lys Leu Pro Leu Gly Gln Ser Leu Cys 
                725                 730                 735     


Ala Leu Pro Asp Thr Pro Ser Thr Leu Thr Pro Arg Ser Val Arg Ser 
            740                 745                 750         


Val Pro Gly Glu Met Arg Leu Ala Ser Ile Ala Phe Asn His Pro Ile 
        755                 760                 765             


Gln Val Asp Gln Leu Asn Ser Ser Tyr Phe Lys Leu Ser Ile Pro Thr 
    770                 775                 780                 


Asn Phe Ser Phe Gly Val Thr Gln Glu Tyr Ile Gln Thr Thr Ile Gln 
785                 790                 795                 800 


Lys Val Thr Val Asp Cys Lys Gln Tyr Val Cys Asn Gly Phe Gln Lys 
                805                 810                 815     


Cys Glu Gln Leu Leu Arg Glu Tyr Gly Gln Phe Cys Ser Lys Ile Asn 
            820                 825                 830         


Gln Ala Leu His Gly Ala Asn Leu Arg Gln Asp Asp Ser Val Arg Asn 
        835                 840                 845             


Leu Phe Ala Ser Val Lys Ser Ser Gln Ser Ser Pro Ile Ile Pro Gly 
    850                 855                 860                 


Phe Gly Gly Asp Phe Asn Leu Thr Leu Leu Glu Pro Val Ser Ile Ser 
865                 870                 875                 880 


Thr Gly Ser Arg Ser Ala Arg Ser Ala Ile Glu Asp Leu Leu Phe Asp 
                885                 890                 895     


Lys Val Thr Ile Ala Asp Pro Gly Tyr Met Gln Gly Tyr Asp Asp Cys 
            900                 905                 910         


Met Gln Gln Gly Pro Ala Ser Ala Arg Asp Leu Ile Cys Ala Gln Tyr 
        915                 920                 925             


Val Ala Gly Tyr Lys Val Leu Pro Pro Leu Met Asp Val Asn Met Glu 
    930                 935                 940                 


Ala Ala Tyr Thr Ser Ser Leu Leu Gly Ser Ile Ala Gly Val Gly Trp 
945                 950                 955                 960 


Thr Ala Gly Leu Ser Ser Phe Ala Ala Ile Pro Phe Ala Gln Ser Ile 
                965                 970                 975     


Phe Tyr Arg Leu Asn Gly Val Gly Ile Thr Gln Gln Val Leu Ser Glu 
            980                 985                 990         


Asn Gln Lys Leu Ile Ala Asn Lys  Phe Asn Gln Ala Leu  Gly Ala Met 
        995                 1000                 1005             


Gln Thr  Gly Phe Thr Thr Thr  Asn Glu Ala Phe Gln  Lys Val Gln 
    1010                 1015                 1020             


Asp Ala  Val Asn Asn Asn Ala  Gln Ala Leu Ser Lys  Leu Ala Ser 
    1025                 1030                 1035             


Glu Leu  Ser Asn Thr Phe Gly  Ala Ile Ser Ala Ser  Ile Gly Asp 
    1040                 1045                 1050             


Ile Ile  Gln Arg Leu Asp Val  Leu Glu Gln Asp Ala  Gln Ile Asp 
    1055                 1060                 1065             


Arg Leu  Ile Asn Gly Arg Leu  Thr Thr Leu Asn Ala  Phe Val Ala 
    1070                 1075                 1080             


Gln Gln  Leu Val Arg Ser Glu  Ser Ala Ala Leu Ser  Ala Gln Leu 
    1085                 1090                 1095             


Ala Lys  Asp Lys Val Asn Glu  Cys Val Lys Ala Gln  Ser Lys Arg 
    1100                 1105                 1110             


Ser Gly  Phe Cys Gly Gln Gly  Thr His Ile Val Ser  Phe Val Val 
    1115                 1120                 1125             


Asn Ala  Pro Asn Gly Leu Tyr  Phe Met His Val Gly  Tyr Tyr Pro 
    1130                 1135                 1140             


Ser Asn  His Ile Glu Val Val  Ser Ala Tyr Gly Leu  Cys Asp Ala 
    1145                 1150                 1155             


Ala Asn  Pro Thr Asn Cys Ile  Ala Pro Val Asn Gly  Tyr Phe Ile 
    1160                 1165                 1170             


Lys Thr  Asn Asn Thr Arg Ile  Val Asp Glu Trp Ser  Tyr Thr Gly 
    1175                 1180                 1185             


Ser Ser  Phe Tyr Ala Pro Glu  Pro Ile Thr Ser Leu  Asn Thr Lys 
    1190                 1195                 1200             


Tyr Val  Ala Pro Gln Val Thr  Tyr Gln Asn Ile Ser  Thr Asn Leu 
    1205                 1210                 1215             


Pro Pro  Pro Leu Leu Gly Asn  Ser Thr Gly Ile Asp  Phe Gln Asp 
    1220                 1225                 1230             


Glu Leu  Asp Glu Phe Phe Lys  Asn Val Ser Thr Ser  Ile Pro Asn 
    1235                 1240                 1245             


Phe Gly  Ser Leu Thr Gln Ile  Asn Thr Thr Leu Leu  Asp Leu Thr 
    1250                 1255                 1260             


Tyr Glu  Met Leu Ser Leu Gln  Gln Val Val Lys Ala  Leu Asn Glu 
    1265                 1270                 1275             


Ser Tyr  Ile Asp Leu Lys Glu  Leu Gly Asn Tyr Thr  
    1280                 1285                 1290 


<210>  124
<211>  222
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the spike protein RBD of SARS-CoV

<400>  124

Arg Val Val Pro Ser Gly Asp Val Val Arg Phe Pro Asn Ile Thr Asn 
1               5                   10                  15      


Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Lys Phe Pro Ser Val 
            20                  25                  30          


Tyr Ala Trp Glu Arg Lys Lys Ile Ser Asn Cys Val Ala Asp Tyr Ser 
        35                  40                  45              


Val Leu Tyr Asn Ser Thr Phe Phe Ser Thr Phe Lys Cys Tyr Gly Val 
    50                  55                  60                  


Ser Ala Thr Lys Leu Asn Asp Leu Cys Phe Ser Asn Val Tyr Ala Asp 
65                  70                  75                  80  


Ser Phe Val Val Lys Gly Asp Asp Val Arg Gln Ile Ala Pro Gly Gln 
                85                  90                  95      


Thr Gly Val Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Met 
            100                 105                 110         


Gly Cys Val Leu Ala Trp Asn Thr Arg Asn Ile Asp Ala Thr Ser Thr 
        115                 120                 125             


Gly Asn Tyr Asn Tyr Lys Tyr Arg Tyr Leu Arg His Gly Lys Leu Arg 
    130                 135                 140                 


Pro Phe Glu Arg Asp Ile Ser Asn Val Pro Phe Ser Pro Asp Gly Lys 
145                 150                 155                 160 


Pro Cys Thr Pro Pro Ala Leu Asn Cys Tyr Trp Pro Leu Asn Asp Tyr 
                165                 170                 175     


Gly Phe Tyr Thr Thr Thr Gly Ile Gly Tyr Gln Pro Tyr Arg Val Val 
            180                 185                 190         


Val Leu Ser Phe Glu Leu Leu Asn Ala Pro Ala Thr Val Cys Gly Pro 
        195                 200                 205             


Lys Leu Ser Thr Asp Leu Ile Lys Asn Gln Cys Val Asn Phe 
    210                 215                 220         


<210>  125
<211>  666
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid sequence of the spike protein RBD of SARS-CoV

<400>  125
cgggtggtgc ccagcggcga cgtggtgcgg ttccccaaca tcaccaacct gtgccccttc       60

ggcgaggtgt tcaacgccac caagttcccc agcgtgtacg cctgggagcg gaagaagatc      120

agcaactgcg tggccgacta cagcgtgctg tacaacagca ccttcttcag caccttcaag      180

tgctacggcg tgagcgccac caagctgaac gacctgtgct tcagcaacgt gtacgccgac      240

agcttcgtgg tgaagggcga cgacgtgcgg cagatcgccc ccggccagac cggcgtgatc      300

gccgactaca actacaagct gcccgacgac ttcatgggct gcgtgctggc ctggaacacc      360

cggaacatcg acgccaccag caccggcaac tacaactaca agtaccggta cctgcggcac      420

ggcaagctgc ggcccttcga gcgggacatc agcaacgtgc ccttcagccc cgacggcaag      480

ccctgcaccc cccccgccct gaactgctac tggcccctga acgactacgg cttctacacc      540

actaccggca tcggctacca gccctaccgg gtggtggtgc tgagcttcga gctgctgaac      600

gcccccgcca ccgtgtgcgg ccccaagctg agcaccgacc tgatcaagaa ccagtgcgtg      660

aacttc                                                                 666


<210>  126
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the spike protein RBD of MERS-CoV

<400>  126

Val Glu Cys Asp Phe Ser Pro Leu Leu Ser Gly Thr Pro Pro Gln Val 
1               5                   10                  15      


Tyr Asn Phe Lys Arg Leu Val Phe Thr Asn Cys Asn Tyr Asn Leu Thr 
            20                  25                  30          


Lys Leu Leu Ser Leu Phe Ser Val Asn Asp Phe Thr Cys Ser Gln Ile 
        35                  40                  45              


Ser Pro Ala Ala Ile Ala Ser Asn Cys Tyr Ser Ser Leu Ile Leu Asp 
    50                  55                  60                  


Tyr Phe Ser Tyr Pro Leu Ser Met Lys Ser Asp Leu Ser Val Ser Ser 
65                  70                  75                  80  


Ala Gly Pro Ile Ser Gln Phe Asn Tyr Lys Gln Ser Phe Ser Asn Pro 
                85                  90                  95      


Thr Cys Leu Ile Leu Ala Thr Val Pro His Asn Leu Thr Thr Ile Thr 
            100                 105                 110         


Lys Pro Leu Lys Tyr Ser Tyr Ile Asn Lys Cys Ser Arg Leu Leu Ser 
        115                 120                 125             


Asp Asp Arg Thr Glu Val Pro Gln Leu Val Asn Ala Asn Gln Tyr Ser 
    130                 135                 140                 


Pro Cys Val Ser Ile Val Pro Ser Thr Val Trp Glu Asp Gly Asp Tyr 
145                 150                 155                 160 


Tyr Arg Lys Gln Leu Ser Pro Leu Glu Gly Gly Gly Trp Leu Val Ala 
                165                 170                 175     


Ser Gly Ser Thr Val Ala Met Thr Glu Gln Leu Gln Met Gly Phe Gly 
            180                 185                 190         


Ile Thr Val Gln Tyr Gly Thr Asp Thr Asn Ser Val Cys Pro Lys Leu 
        195                 200                 205             


<210>  127
<211>  624
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid sequence of the spike protein RBD of MERS-CoV

<400>  127
gtggagtgtg acttcagccc actgctgtct ggcacacctc cacaggtcta caacttcaag       60

agactggtgt tcaccaactg taactacaac ctgaccaaac tgctgtccct gttctctgtg      120

aatgacttca cttgtagcca gattagccct gctgccattg ccagcaactg ttactcctcc      180

ctgattctgg actacttctc ctacccactg agtatgaagt ctgacctgtc tgtgtcctct      240

gctggaccaa tcagccagtt caactacaag cagtccttca gcaacccaac ttgtctgatt      300

ctggctacag tgccacacaa cctgaccacc atcaccaagc cactgaaata ctcctacatc      360

aacaagtgta gcagactgct gtctgatgac aggacagagg tgccacaact agtgaatgcc      420

aaccaataca gcccatgtgt gagcattgtg ccaagcacag tgtgggagga tggagactac      480

tacaggaagc aacttagccc attggaggga ggaggctggc tggtggcatc tggcagcaca      540

gtggctatga cagaacaact ccaaatgggc tttggcatca cagtccaata tggcacagac      600

accaactctg tgtgtccaaa attg                                             624


<210>  128
<211>  223
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the spike protein RBD of SARS-CoV-2

<400>  128

Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn 
1               5                   10                  15      


Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val 
            20                  25                  30          


Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser 
        35                  40                  45              


Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val 
    50                  55                  60                  


Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp 
65                  70                  75                  80  


Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln 
                85                  90                  95      


Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr 
            100                 105                 110         


Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly 
        115                 120                 125             


Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys 
    130                 135                 140                 


Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr 
145                 150                 155                 160 


Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser 
                165                 170                 175     


Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val 
            180                 185                 190         


Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly 
        195                 200                 205             


Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe 
    210                 215                 220             


<210>  129
<211>  669
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid sequence of the spike protein RBD of SARS-CoV-2

<400>  129
cgcgtgcagc ccaccgagag catcgtgcgc ttccccaaca tcaccaacct gtgccccttc       60

ggcgaggtgt tcaacgccac ccgcttcgcc agcgtgtacg cctggaaccg caagcgcatc      120

agcaactgcg tggccgacta cagcgtgctg tacaacagcg ccagcttcag caccttcaag      180

tgctacggcg tgagccccac caagctgaac gacctgtgct tcaccaacgt gtacgccgac      240

agcttcgtga tccgcggcga cgaggtgcgc cagatcgccc ccggccagac cggcaagatc      300

gccgactaca actacaagct gcccgacgac ttcaccggct gcgtgatcgc ctggaacagc      360

aacaacctgg acagcaaggt gggcggcaac tacaactacc tgtaccgcct gttccgcaag      420

agcaacctga agcccttcga gcgcgacatc agcaccgaga tctaccaggc cggcagcacc      480

ccctgcaacg gcgtggaggg cttcaactgc tacttccccc tgcagagcta cggcttccag      540

cccaccaacg gcgtgggcta ccagccctac cgcgtggtgg tgctgagctt cgagctgctg      600

cacgcccccg ccaccgtgtg cggccccaag aagagcacca acctggtgaa gaacaagtgc      660

gtgaacttc                                                              669


<210>  130
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Signal peptide

<400>  130

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser 
            


<210>  131
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Signal peptide

<400>  131

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Ser Trp Ala 
            


<210>  132
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  6XHis Tag

<400>  132

His His His His His His 
1               5       


<210>  133
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Tag

<400>  133

Met Ser Tyr Tyr His His His His His His 
1               5                   10  


<210>  134
<211>  1281
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of full length S protein of SARS-CoV-2

<400>  134

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
                245                 250                 255     


Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270         


Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285             


Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                 


Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
305                 310                 315                 320 


Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 
                325                 330                 335     


Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 
            340                 345                 350         


Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
        355                 360                 365             


Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
    370                 375                 380                 


Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
385                 390                 395                 400 


Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
                405                 410                 415     


Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
            420                 425                 430         


Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
        435                 440                 445             


Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
    450                 455                 460                 


Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
465                 470                 475                 480 


Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
                485                 490                 495     


Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
            500                 505                 510         


Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
        515                 520                 525             


Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
    530                 535                 540                 


Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
545                 550                 555                 560 


Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 
                565                 570                 575     


Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 
            580                 585                 590         


Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 
        595                 600                 605             


Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile 
    610                 615                 620                 


His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 
625                 630                 635                 640 


Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val 
                645                 650                 655     


Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 
            660                 665                 670         


Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala 
        675                 680                 685             


Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser 
    690                 695                 700                 


Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile 
705                 710                 715                 720 


Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 
                725                 730                 735     


Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu 
            740                 745                 750         


Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr 
        755                 760                 765             


Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln 
    770                 775                 780                 


Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe 
785                 790                 795                 800 


Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser 
                805                 810                 815     


Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly 
            820                 825                 830         


Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp 
        835                 840                 845             


Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu 
    850                 855                 860                 


Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly 
865                 870                 875                 880 


Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile 
                885                 890                 895     


Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr 
            900                 905                 910         


Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn 
        915                 920                 925             


Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala 
    930                 935                 940                 


Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn 
945                 950                 955                 960 


Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val 
                965                 970                 975     


Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln 
            980                 985                 990         


Ile Asp Arg Leu Ile Thr Gly Arg  Leu Gln Ser Leu Gln  Thr Tyr Val 
        995                 1000                 1005             


Thr Gln  Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
    1010                 1015                 1020             


Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1025                 1030                 1035             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1040                 1045                 1050             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1055                 1060                 1065             


Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1070                 1075                 1080             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1085                 1090                 1095             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1100                 1105                 1110             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1115                 1120                 1125             


Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro 
    1130                 1135                 1140             


Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Tyr  Phe Lys Asn 
    1145                 1150                 1155             


His Thr  Ser Pro Asp Val Asp  Leu Gly Asp Ile Ser  Gly Ile Asn 
    1160                 1165                 1170             


Ala Ser  Val Val Asn Ile Gln  Lys Glu Ile Asp Arg  Leu Asn Glu 
    1175                 1180                 1185             


Val Ala  Lys Asn Leu Asn Glu  Ser Leu Ile Asp Leu  Gln Glu Leu 
    1190                 1195                 1200             


Gly Lys  Tyr Glu Gln Tyr Ile  Lys Trp Pro Trp Tyr  Ile Trp Leu 
    1205                 1210                 1215             


Gly Phe  Ile Ala Gly Leu Ile  Ala Ile Val Met Val  Thr Ile Met 
    1220                 1225                 1230             


Leu Cys  Cys Met Thr Ser Cys  Cys Ser Cys Leu Lys  Gly Cys Cys 
    1235                 1240                 1245             


Ser Cys  Gly Ser Cys Cys Lys  Phe Asp Glu Asp Asp  Ser Glu Pro 
    1250                 1255                 1260             


Val Leu  Lys Gly Val Lys Leu  His Tyr Thr Trp Ser  His Pro Gln 
    1265                 1270                 1275             


Phe Glu  Lys 
    1280     


<210>  135
<211>  3846
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid sequence of full length S protein of SARS-CoV-2

<400>  135
atgttcgtgt tcctggtgct gctgcctctg gtgagcagcc agtgcgtgaa tctgaccacc       60

agaacccagc tgcctcctgc ctacaccaat agcttcacca gaggagttta ttatcccgat      120

aaggtgttca gaagtagtgt attacatagt acccaggacc tgttcctacc tttcttcagt      180

aacgtgacct ggttccacgc catccacgtg agcggcacca atggcaccaa gagattcgac      240

aatcctgtgc tgcctttcaa tgacggcgtg tacttcgcca gcaccgagaa gagcaatatc      300

atcagaggct ggatcttcgg caccaccttg gattccaaga ctcagagcct gctgattgta      360

aacaacgcta caaatgtggt gatcaaggtg tgcgagttcc agttctgcaa tgaccctttc      420

ctgggtgttt attatcataa gaacaacaag agctggatgg agagcgagtt ccgcgtatat      480

tcgtcggcta ataattgcac cttcgagtac gtgagccagc ctttcctgat ggacctggag      540

ggcaagcagg gcaatttcaa gaatctgaga gagttcgtgt tcaagaatat cgacggctac      600

ttcaagatct acagcaagca cacacccatt aatctggtga gagacctgcc tcagggcttc      660

agcgccctgg agcctctggt ggacctgcct atcggcatca atatcaccag attccagacc      720

ctgctggccc tgcacagatc atatcttaca ccaggcgatt cgtcaagcgg ttggaccgct      780

ggagctgcgg catattacgt gggctacctg cagcctagaa ccttcctgct gaagtacaat      840

gagaatggta cgataaccga cgcagttgat tgtgccctgg accctctgag cgagaccaag      900

tgcaccctga agagcttcac cgtggagaag ggcatctacc agaccagcaa tttcagagtg      960

cagcctaccg agagcatcgt gagattccct aatatcacca atctgtgccc tttcggcgag     1020

gtgttcaatg ccaccagatt cgccagcgtg tacgcatgga accgcaagcg gataagcaat     1080

tgcgtggccg actacagcgt gctgtacaat agcgccagct tcagcacctt caaatgttat     1140

ggtgtttcgc caacaaagct gaatgacctg tgcttcacca atgtgtacgc cgacagcttc     1200

gtgatcagag gcgacgaggt gagacagatc gcgccagggc agaccggcaa gatcgccgac     1260

tacaattaca agctgcctga cgacttcacc ggctgcgtga tcgcgtggaa ctctaacaat     1320

ctagattcga aagttggagg caattacaat tacctgtaca gactgttcag aaagagcaat     1380

ctgaagcctt tcgagagaga catcagcacc gagatctacc aggccggcag cacaccgtgt     1440

aatggcgtgg agggcttcaa ttgctacttc cctctgcaga gctacggctt ccagcctacc     1500

aatggcgtgg gctaccagcc ttacagagtg gtggtgctga gcttcgagct gctgcacgct     1560

cccgctaccg tgtgcggccc taagaagagc accaatctgg tgaagaataa gtgcgtgaat     1620

ttcaatttca atggtctaac tggaacgggc gtgctgaccg agagcaataa gaagtttctt     1680

ccctttcaac aattcggcag agacatcgcc gacaccacag atgctgtaag agaccctcag     1740

accctggaga tcctggacat cactccgtgt agcttcggcg gcgtgagcgt gatcacaccg     1800

ggtaccaata ccagcaatca ggtggccgtg ctgtaccagg acgtgaattg caccgaggtg     1860

cctgtggcca tccacgccga ccagctgact cccacttgga gggtatattc cacgggaagc     1920

aatgtgttcc agaccagagc cggctgcctg atcggcgccg agcacgtgaa taatagctac     1980

gagtgcgaca tccctatcgg cgccggcatc tgcgccagct accagaccca gaccaatagc     2040

cctagaagag ccagaagcgt ggccagccag agcatcatcg cctacaccat gagcctgggc     2100

gccgagaata gcgtggccta cagcaataat agcatcgcca tccctaccaa tttcaccatc     2160

agcgtgacca ccgaaatatt accagtctcc atgaccaaga ccagcgtgga ctgcaccatg     2220

tacatctgcg gcgacagcac cgagtgcagc aatctgctgc tgcagtacgg cagcttctgc     2280

acccagctga atagagccct gaccggcatc gccgtggagc aggacaagaa tacccaggag     2340

gtgttcgccc aggtgaagca gatctacaag actccgccga tcaaggactt cggcggcttc     2400

aatttcagcc aaatactccc agatccaagc aagcctagca agaggagctt catcgaggac     2460

ctgctgttca ataaggtgac cctggccgac gccggcttca tcaagcagta cggcgactgc     2520

ctaggtgata ttgcggcaag agacctgatc tgcgcccaga agtttaacgg tttgacagta     2580

ctacctcctc tgctgaccga cgagatgata gcacaatata cgtcggcatt gctcgctggc     2640

acgatcacat cgggctggac tttcggcgcc ggagcagcgt tgcaaatccc tttcgccatg     2700

cagatggcct acagattcaa tggcatcggc gtgacccaga atgtgctgta cgagaatcag     2760

aagctgatcg ccaatcagtt caatagcgcc atcggcaaga tccaggacag cctgagcagc     2820

accgccagcg ccctgggcaa gctgcaggac gtggtgaatc agaatgccca ggccctgaat     2880

accctggtga agcagctgag cagcaatttc ggcgccatca gtagtgtact caacgatatc     2940

ctgagcagac tggacaaggt ggaggccgag gtgcaaattg atcgtcttat tactggcaga     3000

ctgcagagcc tgcagaccta cgtgacccag cagctgatca gagccgccga gatcagagcc     3060

agcgccaatc tggccgccac caagatgagc gagtgcgtgc tgggccagag caagagagtg     3120

gacttctgcg gcaagggcta ccacctgatg agcttccctc agagcgctcc acatggcgtg     3180

gtgttcctgc acgtgaccta cgtgcctgcc caggagaaga atttcaccac cgcacccgca     3240

atctgccacg acggcaaggc ccacttccct agagagggcg tgttcgtgag caatggcacc     3300

cactggttcg tgacccagag aaatttctac gagcctcaga tcatcaccac cgacaatacc     3360

ttcgtgagcg gcaattgcga cgtggtgatc gggatagtca ataatactgt ctacgaccct     3420

ctgcagcctg agctggacag cttcaaggag gagctggaca agtacttcaa gaatcacacc     3480

agccctgacg tggacctcgg tgatatttcg ggaatcaatg ccagcgtggt gaatatccag     3540

aaggaaattg atcggctcaa cgaagtggcc aagaatctga atgagagcct gatcgacctg     3600

caggagctgg gcaagtacga gcagtacatc aagtggcctt ggtacatctg gctgggcttc     3660

atcgccggcc tgatcgccat cgtgatggtg accatcatgc tgtgctgcat gacctcctgt     3720

tgttcctgtt tgaaagggtg ttgttcgtgt gggtcctgct gcaagttcga cgaggacgac     3780

agcgagcctg tgctgaaggg cgtgaagctg cactacacct ggagccaccc tcagttcgag     3840

aagtga                                                                3846


<210>  136
<211>  8
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P2B-1G5 HCDR1
<222>  (1)..(8)

<400>  136

Gly Tyr Thr Phe Thr Thr Tyr Val 
1               5               


<210>  137
<211>  8
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P2B-1G5 HCDR2
<222>  (1)..(8)

<400>  137

Ile Asn Thr Asn Thr Gly Asn Pro 
1               5               


<210>  138
<211>  12
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P2B-1G5 HCDR3
<222>  (1)..(12)

<400>  138

Ser Cys Glu Ile Thr Thr Leu Gly Gly Met Asp Val 
1               5                   10          


<210>  139
<211>  6
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P2B-1G5 LCDR1
<222>  (1)..(6)

<400>  139

Asn Ile Gly Ser Lys Ser 
1               5       


<210>  140
<211>  4
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P2B-1G5 LCDR2
<222>  (1)..(3)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa is absent.

<400>  140

Tyr Asp Ser Xaa 
1               


<210>  141
<211>  11
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P2B-1G5 LCDR3
<222>  (1)..(11)

<400>  141

Gln Val Trp Asp Ser Ile Ser Asp His Arg Val 
1               5                   10      


<210>  142
<211>  119
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P2B-1G5 VH
<222>  (1)..(119)

<400>  142

Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Thr Tyr 
            20                  25                  30          


Val Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Asn Thr Gly Asn Pro Thr Tyr Ala Gln Gly Phe 
    50                  55                  60                  


Thr Gly Arg Phe Val Phe Ser Leu Asp Thr Ser Val Ser Thr Ala Ser 
65                  70                  75                  80  


Leu Gln Ile Ser Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Cys Glu Ile Thr Thr Leu Gly Gly Met Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser 
        115                 


<210>  143
<211>  108
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P2B-1G5 VL
<222>  (1)..(108)

<400>  143

Ser Tyr Val Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Lys 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly Ser Lys Ser Val 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Tyr Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Val Glu Ala Gly 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Ser Ile Ser Asp His 
                85                  90                  95      


Arg Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105             


<210>  144
<211>  357
<212>  DNA
<213>  Homo sapiens


<220>
<221>  P2B-1G5 VHnu
<222>  (1)..(357)

<400>  144
caggtgcagc tggtgcaatc tgggtctgag ttgaagaagc ctggggcctc agtgaaggtt       60

tcctgcaagg cttctggata caccttcact acctatgtta tgaattgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggatgg atcaacacca acactgggaa cccaacgtat      180

gcccagggct tcacaggacg gtttgtcttc tccttggaca cctctgtcag cacggcatct      240

ctgcagatca gcagcctaaa ggctgaggac actgccgtgt attactgttc gtgtgaaata      300

accaccttgg gcggtatgga cgtctggggc caagggacca cggtcaccgt ctcctca         357


<210>  145
<211>  324
<212>  DNA
<213>  Homo sapiens


<220>
<221>  P2B-1G5 VLnu
<222>  (1)..(324)

<400>  145
tcctatgtgc tgactcagcc accctcagtg tcagtggccc caggaaagac ggccaggatt       60

acctgtgggg gaaacaacat tggaagtaaa agtgtgcact ggtaccagca gaagccaggc      120

caggcccctg tgctggtcat ctattatgat agcgaccggc cctcagggat ccctgagcga      180

ttctctggct ccaactctgg gaacacggcc accctgacca tcagcggggt cgaagccggg      240

gatgaggccg actattactg tcaggtgtgg gatagtatta gtgatcatcg ggtgttcggc      300

ggagggacca agctgaccgt ccta                                             324


<210>  146
<211>  8
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P2B-1A1 HCDR1
<222>  (1)..(8)

<400>  146

Gly Gly Ser Ile Ser Ser Tyr Tyr 
1               5               


<210>  147
<211>  7
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P2B-1A1 HCDR2
<222>  (1)..(7)

<400>  147

Ile Tyr Tyr Ser Gly Ser Thr 
1               5           


<210>  148
<211>  14
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P2B-1A1 HCDR3
<222>  (1)..(14)

<400>  148

Ala Arg Leu Glu Arg Asp Trp Pro Leu Asp Ala Phe Asp Ile 
1               5                   10                  


<210>  149
<211>  9
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P2B-1A1 LCDR1
<222>  (1)..(9)

<400>  149

Ser Ser Asp Val Gly Gly Tyr Asn Tyr 
1               5                   


<210>  150
<211>  4
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P2B-1A1 LCDR2
<222>  (1)..(3)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa is absent.

<400>  150

Asp Val Ser Xaa 
1               


<210>  151
<211>  10
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P2B-1A1 LCDR3
<222>  (1)..(10)

<400>  151

Ser Ser Tyr Thr Ser Asn Asn Thr Phe Ala 
1               5                   10  


<210>  152
<211>  120
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P2B-1A1 VH
<222>  (1)..(120)

<400>  152

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Tyr 
            20                  25                  30          


Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Lys Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Leu Glu Arg Asp Trp Pro Leu Asp Ala Phe Asp Ile Trp Gly Gln 
            100                 105                 110         


Gly Thr Met Val Thr Val Ser Ser 
        115                 120 


<210>  153
<211>  110
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P2B-1A1 VL
<222>  (1)..(110)

<400>  153

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Phe 
        35                  40                  45              


Met Ile Tyr Asp Val Ser Lys Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Ser Asn 
                85                  90                  95      


Asn Thr Phe Ala Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  154
<211>  360
<212>  DNA
<213>  Homo sapiens


<220>
<221>  P2B-1A1 VHnu
<222>  (1)..(360)

<400>  154
caggtgcagc tgcaggagtc gggcccagga ctggtgaagc cttcggagac cctgtccctc       60

acctgcactg tctctggtgg ctccatcagt agttactact ggagctggat ccggcagccc      120

ccagggaagg gactggagtg gattgggtat atctattaca gtgggagcac caactacaac      180

ccctccctca agagtcgagt caccatatca gtagacacgt ccaagaagca gttctccctg      240

aagctgagct ctgtgaccgc tgcggacacg gccgtgtatt actgtgcgag gctcgaacga      300

gactggccac ttgatgcttt tgatatctgg ggccaaggga caatggtcac cgtctcctca      360


<210>  155
<211>  330
<212>  DNA
<213>  Homo sapiens


<220>
<221>  P2B-1A1 VLnu
<222>  (1)..(330)

<400>  155
cagtctgccc tgactcagcc tgcctccgtg tctgggtctc ctggacagtc gatcaccatc       60

tcctgcactg gaaccagcag tgacgttggt ggttataact atgtctcctg gtaccaacag      120

cacccaggca aagcccccaa attcatgatt tatgatgtca gtaagcggcc ctcaggggtt      180

tctaatcgct tctctggctc caagtctggc aacacggcct ccctgaccat ctctgggctc      240

caggctgagg acgaggctga ttattactgc agctcatata caagcaacaa cactttcgcg      300

ttcggcggag ggaccaagct gaccgtccta                                       330


<210>  156
<211>  8
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P2C-1D7 HCDR1
<222>  (1)..(8)

<400>  156

Gly Phe Thr Val Ser Ser Asn Tyr 
1               5               


<210>  157
<211>  7
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P2C-1D7 HCDR2
<222>  (1)..(7)

<400>  157

Ile Tyr Ser Gly Gly Ser Thr 
1               5           


<210>  158
<211>  12
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P2C-1D7 HCDR3
<222>  (1)..(12)

<400>  158

Ala Arg Glu Leu Tyr Glu Val Gly Ala Thr Asp Tyr 
1               5                   10          


<210>  159
<211>  11
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P2C-1D7 LCDR1
<222>  (1)..(11)

<400>  159

Gln Ser Leu Val Tyr Ser Asp Gly Asn Thr Tyr 
1               5                   10      


<210>  160
<211>  4
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P2C-1D7 LCDR2
<222>  (1)..(3)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa is absent.

<400>  160

Lys Val Ser Xaa 
1               


<210>  161
<211>  9
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P2C-1D7 LCDR3
<222>  (1)..(9)

<400>  161

Met Gln Arg Tyr Thr Leu Ala Gly Val 
1               5                   


<210>  162
<211>  118
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P2C-1D7 VH
<222>  (1)..(118)

<400>  162

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ile Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ser Asn 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Tyr Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Glu Leu Tyr Glu Val Gly Ala Thr Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  163
<211>  112
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P2C-1D7 VL
<222>  (1)..(112)

<400>  163

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val Tyr Ser 
            20                  25                  30          


Asp Gly Asn Thr Tyr Leu Asn Trp Phe Gln Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Arg Leu Ile Tyr Lys Val Ser Asn Trp Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Arg 
                85                  90                  95      


Tyr Thr Leu Ala Gly Val Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 
            100                 105                 110         


<210>  164
<211>  354
<212>  DNA
<213>  Homo sapiens


<220>
<221>  P2C-1D7 VHnu
<222>  (1)..(354)

<400>  164
gaggtgcagc tggtggagtc tggaggaggc ttgatccagc ctggggggtc cctgagactc       60

tcctgtgcag cctctgggtt caccgtcagt agcaactaca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcagtt atttatagcg gtggtagcac atactacgca      180

gactccgtga agggccgatt caccatctcc agagacaatt ccaagaacac gctgtatctt      240

caaatgaaca gcctgagagc cgaggacacg gccgtgtatt actgtgcgag agaattgtac      300

gaagtgggag ctacggacta ctggggccag ggaaccctgg tcaccgtctc ctca            354


<210>  165
<211>  336
<212>  DNA
<213>  Homo sapiens


<220>
<221>  P2C-1D7 VLnu
<222>  (1)..(336)

<400>  165
gatgttgtga tgactcagtc tccactctcc ctgcccgtca cccttggaca gccggcctcc       60

atctcctgca ggtctagtca aagcctcgta tacagtgatg gaaacaccta cttgaattgg      120

tttcagcaga ggccaggcca atctccaagg cgcctaattt ataaggtttc taactgggac      180

tctggggtcc cagacagatt cagcggcagt gggtcaggca ctgatttcac actgaaaatc      240

agcagggtgg aggctgagga tgttggggtt tattactgca tgcaacggta cacactggcc      300

ggcgttttcg gccctgggac caaagtggat atcaaa                                336


<210>  166
<211>  8
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P2B-1A10 HCDR1
<222>  (1)..(8)

<400>  166

Gly Phe Thr Val Ser Ser Asn Tyr 
1               5               


<210>  167
<211>  7
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P2B-1A10 HCDR2
<222>  (1)..(7)

<400>  167

Ile Tyr Ser Gly Gly Ser Thr 
1               5           


<210>  168
<211>  15
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P2B-1A10 HCDR3
<222>  (1)..(15)

<400>  168

Ala Arg Glu Gly Pro Lys Ser Ile Thr Gly Thr Ala Phe Asp Ile 
1               5                   10                  15  


<210>  169
<211>  6
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P2B-1A10 LCDR1
<222>  (1)..(6)

<400>  169

Gln Asp Ile Ser Asn Tyr 
1               5       


<210>  170
<211>  4
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P2B-1A10 LCDR2
<222>  (1)..(3)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa is absent.

<400>  170

Asp Ala Ser Xaa 
1               


<210>  171
<211>  10
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P2B-1A10 LCDR3
<222>  (1)..(10)

<400>  171

Gln Gln Tyr Asp Asn Leu Pro Met Tyr Thr 
1               5                   10  


<210>  172
<211>  121
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P2B-1A10 VH
<222>  (1)..(121)

<400>  172

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ile Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ser Asn 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Tyr Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Glu Gly Pro Lys Ser Ile Thr Gly Thr Ala Phe Asp Ile Trp Gly 
            100                 105                 110         


Gln Gly Thr Ile Val Thr Val Ser Ser 
        115                 120     


<210>  173
<211>  108
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P2B-1A10 VL
<222>  (1)..(108)

<400>  173

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Phe Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Asn Leu Pro Met 
                85                  90                  95      


Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105             


<210>  174
<211>  363
<212>  DNA
<213>  Homo sapiens


<220>
<221>  P2B-1A10 VHnu
<222>  (1)..(363)

<400>  174
gaggtgcagc tggtggagtc tggaggaggc ttgatccagc ctggggggtc cctgagactc       60

tcctgtgcag cctctgggtt caccgtcagt agcaactaca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcagtt atttatagcg gtggtagcac atactacgca      180

gactccgtga agggccgatt caccatctcc agagacaatt ccaagaacac gctgtatctt      240

caaatgaaca gcctgagagc cgaggacacg gccgtttatt actgtgcgag agagggccca      300

aagtctatta cagggacggc ttttgatatc tggggccaag ggacaattgt caccgtctcc      360

tca                                                                    363


<210>  175
<211>  324
<212>  DNA
<213>  Homo sapiens


<220>
<221>  P2B-1A10 VLnu
<222>  (1)..(324)

<400>  175
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc aggcgagtca ggacattagc aactatttta attggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctacgat gcatccaatt tggaaacagg ggtcccatca      180

aggttcagtg gaagtggatc tgggacagat tttactttca ccatcagcag cctgcagcct      240

gaagatattg caacatatta ctgtcaacag tatgataatc tccccatgta cacttttggc      300

caggggacca agctggagat caaa                                             324


<210>  176
<211>  10
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P2B-1D9 HCDR1
<222>  (1)..(10)

<400>  176

Gly Phe Ser Leu Ser Thr Ser Gly Val Gly 
1               5                   10  


<210>  177
<211>  7
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P2B-1D9 HCDR2
<222>  (1)..(7)

<400>  177

Ile Tyr Trp Asp Asp Asp Lys 
1               5           


<210>  178
<211>  16
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P2B-1D9 HCDR3
<222>  (1)..(16)

<400>  178

Ala His Thr Arg Ile Leu Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asp Tyr 
1               5                   10                  15      


<210>  179
<211>  8
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P2B-1D9 LCDR1
<222>  (1)..(8)

<400>  179

Ser Ser Asn Ile Gly Ser Asn Tyr 
1               5               


<210>  180
<211>  4
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P2B-1D9 LCDR2
<222>  (1)..(3)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa is absent.

<400>  180

Ser Asn Asn Xaa 
1               


<210>  181
<211>  11
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P2B-1D9 LCDR3
<222>  (1)..(11)

<400>  181

Ala Ala Trp Asp Asp Ser Leu Ser Gly Val Val 
1               5                   10      


<210>  182
<211>  124
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P2B-1D9 VH
<222>  (1)..(124)

<400>  182

Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 
            20                  25                  30          


Gly Val Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
        35                  40                  45              


Trp Leu Ala Leu Ile Tyr Trp Asp Asp Asp Lys Tyr Tyr Ser Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Thr Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  


Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala His Thr Arg Ile Leu Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  183
<211>  110
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P2B-1D9 VL
<222>  (1)..(110)

<400>  183

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 
            20                  25                  30          


Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Ser Gly Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  184
<211>  372
<212>  DNA
<213>  Homo sapiens


<220>
<221>  P2B-1D9 VHnu
<222>  (1)..(372)

<400>  184
cagatcacct tgaaggagtc tggtcctacg ctggtgaaac ccacacagac cctcacgctg       60

acctgcacct tctctgggtt ctcactcagc actagtggag tgggtgtggg ctggatccgt      120

cagcccccag gaaaggccct ggagtggctt gcactcattt attgggatga tgataaatac      180

tacagcccat ctctgaagag caggctcacc atcaccaagg acacctccaa aaaccaggtg      240

gtccttacaa tgaccaacat ggaccctgtg gacacagcca catattactg tgcacacact      300

cgcatcttat actatggttc ggggagttat tatgactact ggggccaggg aaccctggtc      360

accgtctcct ca                                                          372


<210>  185
<211>  330
<212>  DNA
<213>  Homo sapiens


<220>
<221>  P2B-1D9 VLnu
<222>  (1)..(330)

<400>  185
cagtctgtgc tgactcagcc accctcagcg tctgggaccc ccgggcagag ggtcaccatc       60

tcttgttctg gaagcagctc caacatcgga agtaattatg tatactggta ccagcagctc      120

ccaggaacgg cccccaaact cctcatctat agtaataatc agcggccctc aggggtccct      180

gaccgattct ctggctccaa gtctggcacc tcagcctccc tggccatcag tgggctccgg      240

tccgaggatg aggctgatta ttactgtgca gcatgggatg acagcctgag tggtgtggta      300

ttcggcggag ggaccaagct gaccgtccta                                       330


<210>  186
<211>  10
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P2B-1E4 HCDR1
<222>  (1)..(10)

<400>  186

Gly Phe Ser Leu Ser Thr Ser Gly Val Gly 
1               5                   10  


<210>  187
<211>  7
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P2B-1E4 HCDR2
<222>  (1)..(7)

<400>  187

Ile Tyr Trp Asp Asp Asp Lys 
1               5           


<210>  188
<211>  11
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P2B-1E4 HCDR3
<222>  (1)..(11)

<400>  188

Ala His Gln Ile Val Ala Thr Ile Ile Asp Tyr 
1               5                   10      


<210>  189
<211>  9
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P2B-1E4 LCDR1
<222>  (1)..(9)

<400>  189

Ser Ser Asp Val Gly Gly Tyr Asn Tyr 
1               5                   


<210>  190
<211>  4
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P2B-1E4 LCDR2
<222>  (1)..(3)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa is absent.

<400>  190

Asp Val Ser Xaa 
1               


<210>  191
<211>  9
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P2B-1E4 LCDR3
<222>  (1)..(9)

<400>  191

Ser Ser Tyr Thr Ser Ser Ser Val Val 
1               5                   


<210>  192
<211>  119
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P2B-1E4 VH
<222>  (1)..(119)

<400>  192

Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 
            20                  25                  30          


Gly Val Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
        35                  40                  45              


Trp Leu Ala Leu Ile Tyr Trp Asp Asp Asp Lys Arg Tyr Ser Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Thr Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  


Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala His Gln Ile Val Ala Thr Ile Ile Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  193
<211>  109
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P2B-1E4 VL
<222>  (1)..(109)

<400>  193

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Asp Val Ser Lys Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Ser Ser 
                85                  90                  95      


Ser Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  194
<211>  357
<212>  DNA
<213>  Homo sapiens


<220>
<221>  P2B-1E4 VHnu
<222>  (1)..(357)

<400>  194
cagatcacct tgaaggagtc tggtcctacg ctggtgaaac ccacacagac cctcacgctg       60

acctgcacct tctctgggtt ctcactcagc actagtggag tgggtgtggg ctggatccgt      120

cagcccccag gaaaggccct ggagtggctt gcactcattt attgggatga tgataagcgc      180

tacagcccat ctctgaagag caggctcacc atcaccaagg acacctccaa aaaccaggtg      240

gtccttacaa tgaccaacat ggaccctgtg gacacagcca catattactg tgcacaccaa      300

atagtggcta cgattattga ctactggggc cagggaaccc tggtcaccgt ctcctca         357


<210>  195
<211>  327
<212>  DNA
<213>  Homo sapiens


<220>
<221>  P2B-1E4 VLnu
<222>  (1)..(327)

<400>  195
cagtctgccc tgactcagcc tgcctccgtg tctgggtctc ctggacagtc gatcaccatc       60

tcctgcactg gaaccagcag tgacgttggt ggttataact atgtctcctg gtaccaacag      120

cacccaggca aagcccccaa actcatgatt tatgatgtca gtaagcggcc ctcaggggtt      180

tctaatcgct tctctggctc caagtctggc aacacggcct ccctgaccat ctctgggctc      240

caggctgagg acgaggctga ttattactgc agctcatata caagcagcag cgtggtattc      300

ggcggaggga ccaagctgac cgtccta                                          327


<210>  196
<211>  8
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P2B-1G1 HCDR1
<222>  (1)..(8)

<400>  196

Gly Phe Thr Val Ser Ser Asn Tyr 
1               5               


<210>  197
<211>  7
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P2B-1G1 HCDR2
<222>  (1)..(7)

<400>  197

Ile Tyr Ser Gly Gly Ser Thr 
1               5           


<210>  198
<211>  11
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P2B-1G1 HCDR3
<222>  (1)..(11)

<400>  198

Ala Arg Asp Tyr Gly Asp Tyr Trp Phe Asp Pro 
1               5                   10      


<210>  199
<211>  7
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P2B-1G1 LCDR1
<222>  (1)..(7)

<400>  199

Gln Ser Val Ser Ser Ser Tyr 
1               5           


<210>  200
<211>  4
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P2B-1G1 LCDR2
<222>  (1)..(3)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa is absent.

<400>  200

Gly Ala Ser Xaa 
1               


<210>  201
<211>  9
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P2B-1G1 LCDR3
<222>  (1)..(9)

<400>  201

Gln Gln Tyr Gly Ser Ser Pro Arg Thr 
1               5                   


<210>  202
<211>  117
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P2B-1G1 VH
<222>  (1)..(117)

<400>  202

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ser Asn 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Tyr Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Tyr Gly Asp Tyr Trp Phe Asp Pro Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  203
<211>  108
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P2B-1G1 VL
<222>  (1)..(108)

<400>  203

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 
                85                  90                  95      


Arg Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105             


<210>  204
<211>  351
<212>  DNA
<213>  Homo sapiens


<220>
<221>  P2B-1G1 VHnu
<222>  (1)..(351)

<400>  204
gaggtgcagc tggtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt caccgtcagt agcaactaca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcagtt atttatagcg gtggtagcac atactacgca      180

gactccgtga agggcagatt caccatctcc agagacaatt ccaagaacac gctgtatctt      240

caaatgaaca gcctgagagc cgaggacacg gctgtgtatt actgtgcgag agactacggt      300

gactactggt tcgacccctg gggccaggga accctggtca ccgtctcctc a               351


<210>  205
<211>  324
<212>  DNA
<213>  Homo sapiens


<220>
<221>  P2B-1G1 VLnu
<222>  (1)..(324)

<400>  205
gaaattgtgt tgacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc       60

ctctcctgca gggccagtca gagtgttagc agcagctact tagcctggta ccagcagaaa      120

cctggccagg ctcccaggct cctcatctat ggtgcatcca gcagggccac tggcatccca      180

gacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagactggag      240

cctgaagatt ttgcagtgta ttactgtcag cagtatggta gctcaccgag gacttttggc      300

caggggacca agctggagat caaa                                             324


<210>  206
<211>  8
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P4A-2D9 HCDR1
<222>  (1)..(8)

<400>  206

Gly Phe Thr Phe Ser Ser Tyr Gly 
1               5               


<210>  207
<211>  8
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P4A-2D9 HCDR2
<222>  (1)..(8)

<400>  207

Ile Ser Asp Asp Gly Ser Asn Gln 
1               5               


<210>  208
<211>  21
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P4A-2D9 HCDR3
<222>  (1)..(21)

<400>  208

Ala Lys Arg Gly Gly Tyr Cys Ser Thr Thr Ser Cys Leu Val Arg Trp 
1               5                   10                  15      


Val Tyr Phe Asp Tyr 
            20      


<210>  209
<211>  6
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P4A-2D9 LCDR1
<222>  (1)..(6)

<400>  209

Gln Phe Ile Ser Ser Tyr 
1               5       


<210>  210
<211>  4
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P4A-2D9 LCDR2
<222>  (1)..(3)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa is absent.

<400>  210

Ala Thr Ser Xaa 
1               


<210>  211
<211>  8
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P4A-2D9 LCDR3
<222>  (1)..(8)

<400>  211

Gln Gln Ser Tyr Asn Thr Leu Thr 
1               5               


<210>  212
<211>  128
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P4A-2D9 VH
<222>  (1)..(128)

<400>  212

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Asp Asp Gly Ser Asn Gln Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Glu Ile Asn Ser Leu Arg Val Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Arg Gly Gly Tyr Cys Ser Thr Thr Ser Cys Leu Val Arg Trp 
            100                 105                 110         


Val Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125             


<210>  213
<211>  106
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P4A-2D9 VL
<222>  (1)..(106)

<400>  213

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Phe Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Thr Ser Ile Leu Gln Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Asn Thr Leu Thr 
                85                  90                  95      


Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 
            100                 105     


<210>  214
<211>  384
<212>  DNA
<213>  Homo sapiens


<220>
<221>  P4A-2D9 VHnu
<222>  (1)..(384)

<400>  214
caggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt agctatggca tgcactgggt ccgccagtct      120

ccaggcaagg ggctggagtg ggtggcagtt atatcagatg atggaagtaa tcaatactat      180

gcagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat      240

ctggaaatca acagcctgag agttgaggac acggctgtgt attactgtgc gaaaaggggc      300

ggatattgta gtactaccag ctgcctcgtt aggtgggtct actttgacta ctggggccag      360

ggaaccctgg tcaccgtctc ctca                                             384


<210>  215
<211>  318
<212>  DNA
<213>  Homo sapiens


<220>
<221>  P4A-2D9 VLnu
<222>  (1)..(318)

<400>  215
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggcaagtca gttcattagc agctacttaa attggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctatgct acatccattt tgcaaactgg ggtcccatca      180

aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct      240

gaagattttg caacttacta ctgtcaacag agttacaata cccttacttt cggccctggg      300

accaaagtcg atatcaaa                                                    318


<210>  216
<211>  10
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P5A-2G7 HCDR1
<222>  (1)..(10)

<400>  216

Gly Asp Ser Val Ser Ser Gly Ser Tyr Tyr 
1               5                   10  


<210>  217
<211>  7
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P5A-2G7 HCDR2
<222>  (1)..(7)

<400>  217

Ile Tyr Tyr Ser Gly Ser Thr 
1               5           


<210>  218
<211>  20
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P5A-2G7 HCDR3
<222>  (1)..(20)

<400>  218

Ala Arg Glu Arg Cys Tyr Tyr Gly Ser Gly Arg Ala Pro Arg Cys Val 
1               5                   10                  15      


Trp Phe Asp Pro 
            20  


<210>  219
<211>  9
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P5A-2G7 LCDR1
<222>  (1)..(9)

<400>  219

Ser Ser Asp Val Gly Gly Tyr Asn Tyr 
1               5                   


<210>  220
<211>  4
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P5A-2G7 LCDR2
<222>  (1)..(3)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa is absent.

<400>  220

Asp Val Ser Xaa 
1               


<210>  221
<211>  11
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P5A-2G7 LCDR3
<222>  (1)..(11)

<400>  221

Ser Ser Tyr Thr Ser Ser Ser Thr Leu Val Val 
1               5                   10      


<210>  222
<211>  128
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P5A-2G7 VH
<222>  (1)..(128)

<400>  222

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Val Ser Ser Gly 
            20                  25                  30          


Ser Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Asn Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Glu Arg Cys Tyr Tyr Gly Ser Gly Arg Ala Pro Arg Cys 
            100                 105                 110         


Val Trp Phe Asp Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125             


<210>  223
<211>  111
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P5A-2G7 VL
<222>  (1)..(111)

<400>  223

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Asp Val Ser Asn Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Ser Ser 
                85                  90                  95      


Ser Thr Leu Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110     


<210>  224
<211>  384
<212>  DNA
<213>  Homo sapiens


<220>
<221>  P5A-2G7 VHnu
<222>  (1)..(384)

<400>  224
caggtgcagc tgcaggagtc gggcccagga ctggtgaagc cttcggagac cctgtccctc       60

acctgcactg tctctggtga ctccgtcagc agtggtagtt actactggag ctggatccgg      120

cagcccccag ggaagggact ggagtggatt gggtatatct attacagtgg gagcaccaac      180

tacaacccct ccctcaagag tcgagtcacc atatcagtag acacgtccaa gaaccagttc      240

tccctgaagc tgagctctgt gaccgctgcg gacacggccg tgtattactg tgcgagagag      300

cgatgttact atggttcagg gagagccccc cgttgtgtct ggttcgaccc ctggggccag      360

ggaaccctgg tcaccgtctc ctca                                             384


<210>  225
<211>  333
<212>  DNA
<213>  Homo sapiens


<220>
<221>  P5A-2G7 VLnu
<222>  (1)..(333)

<400>  225
cagtctgccc tgactcagcc tgcctccgtg tctgggtctc ctggacagtc gatcaccatc       60

tcctgcactg gaaccagcag tgacgttggt ggttataact atgtctcctg gtaccaacaa      120

cacccaggca aagcccccaa actcatgatt tatgatgtca gtaatcggcc ctcaggggtt      180

tctaatcgct tctctggctc caagtctggc aacacggcct ccctgaccat ctctgggctc      240

caggctgagg acgaggctga ttattactgc agctcatata caagcagcag cactctcgtg      300

gtattcggcg gagggaccaa gctgaccgtc cta                                   333


<210>  226
<211>  8
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P5A-3C8 HCDR1
<222>  (1)..(8)

<400>  226

Gly Phe Thr Val Ser Ser Asn Tyr 
1               5               


<210>  227
<211>  7
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P5A-3C8 HCDR2
<222>  (1)..(7)

<400>  227

Ile Tyr Ser Gly Gly Ser Thr 
1               5           


<210>  228
<211>  11
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P5A-3C8 HCDR3
<222>  (1)..(11)

<400>  228

Ala Arg Asp Leu Gln Glu His Gly Met Asp Val 
1               5                   10      


<210>  229
<211>  6
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P5A-3C8 LCDR1
<222>  (1)..(6)

<400>  229

Gln Gly Ile Ser Ser Tyr 
1               5       


<210>  230
<211>  4
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P5A-3C8 LCDR2
<222>  (1)..(3)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa is absent.

<400>  230

Ala Ala Ser Xaa 
1               


<210>  231
<211>  11
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P5A-3C8 LCDR3
<222>  (1)..(11)

<400>  231

Gln His Leu Asn Ser Tyr Pro Pro Gly Tyr Thr 
1               5                   10      


<210>  232
<211>  117
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P5A-3C8 VH
<222>  (1)..(117)

<400>  232

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ile Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ser Asn 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Phe Ile Tyr Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Leu Gln Glu His Gly Met Asp Val Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  233
<211>  109
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P5A-3C8 VL
<222>  (1)..(109)

<400>  233

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln His Leu Asn Ser Tyr Pro Pro 
                85                  90                  95      


Gly Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 


<210>  234
<211>  351
<212>  DNA
<213>  Homo sapiens


<220>
<221>  P5A-3C8 VHnu
<222>  (1)..(351)

<400>  234
gaggtgcagc tggtggagtc tggaggaggc ttgatccagc ctggggggtc cctgagactc       60

tcctgtgcag cctctgggtt caccgtcagt agcaactaca tgagctgggt ccgccaggct      120

ccagggaagg ggctggaatg ggtctcattt atttatagcg gtggtagtac atactacgca      180

gactccgtga agggccgatt caccatctcc agagacaatt ccaagaacac gctgtatctt      240

caaatgaaca gcctgagagc cgaggacacg gccgtgtatt actgtgcgag agatctacag      300

gaacacggta tggacgtctg gggccaaggg accacggtca ccgtctcctc a               351


<210>  235
<211>  327
<212>  DNA
<213>  Homo sapiens


<220>
<221>  P5A-3C8 VLnu
<222>  (1)..(327)

<400>  235
gacatccagt tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggccagtca gggcattagc agttatttag cctggtatca gcaaaaacca      120

gggaaagccc ctaagctcct gatctatgct gcatccactt tgcaaagtgg ggtcccatca      180

aggttcagcg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct      240

gaagattttg caacttatta ctgtcaacac cttaatagtt accctccggg gtacactttt      300

ggccagggga ccaagctgga gatcaaa                                          327


<210>  236
<211>  8
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P5A-1D2 HCDR1
<222>  (1)..(8)

<400>  236

Gly Phe Ile Val Ser Ser Asn Tyr 
1               5               


<210>  237
<211>  7
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P5A-1D2 HCDR2
<222>  (1)..(7)

<400>  237

Ile Tyr Ser Gly Gly Ser Thr 
1               5           


<210>  238
<211>  15
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P5A-1D2 HCDR3
<222>  (1)..(15)

<400>  238

Ala Arg Ala Leu Gln Val Gly Ala Thr Ser Asp Tyr Phe Asp Tyr 
1               5                   10                  15  


<210>  239
<211>  9
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P5A-1D2 LCDR1
<222>  (1)..(9)

<400>  239

Ser Ser Asn Ile Gly Ala Gly Tyr Asp 
1               5                   


<210>  240
<211>  4
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P5A-1D2 LCDR2
<222>  (1)..(3)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa is absent.

<400>  240

Gly Asn Ser Xaa 
1               


<210>  241
<211>  11
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P5A-1D2 LCDR3
<222>  (1)..(11)

<400>  241

Gln Ser Cys Asp Ser Ser Leu Ser Val Val Val 
1               5                   10      


<210>  242
<211>  121
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P5A-1D2 VH
<222>  (1)..(121)

<400>  242

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ile Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ile Val Ser Ser Asn 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ile Ile Tyr Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Asn Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Ala Leu Gln Val Gly Ala Thr Ser Asp Tyr Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  243
<211>  111
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P5A-1D2 VL
<222>  (1)..(111)

<400>  243

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Thr Asp Tyr Tyr Cys Gln Ser Cys Asp Ser Ser 
                85                  90                  95      


Leu Ser Val Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110     


<210>  244
<211>  363
<212>  DNA
<213>  Homo sapiens


<220>
<221>  P5A-1D2 VHnu
<222>  (1)..(363)

<400>  244
gaggtgcagc tggtggagtc tggaggaggc ttgatccagc ctggggggtc cctgagactc       60

tcctgtgcag cctctgggtt catcgtcagt agcaactaca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcaatt atttatagcg gtggtagcac atactacgca      180

gactccgtga agggccgatt caccatctcc agagacaatt ccaacaacac gctgtatctt      240

caaatgaaca gcctgagagc cgaggacacg gccgtatatt actgtgcgag agccctccag      300

gtgggagcta cttcggacta ctttgactac tggggccagg gaaccctggt caccgtctcc      360

tca                                                                    363


<210>  245
<211>  333
<212>  DNA
<213>  Homo sapiens


<220>
<221>  P5A-1D2 VLnu
<222>  (1)..(333)

<400>  245
cagtctgtgc tgacgcagcc gccctcagtg tctggggccc cagggcagag ggtcaccatc       60

tcctgcactg ggagcagctc caacatcggg gcaggttatg atgtacactg gtaccagcaa      120

cttccaggaa cagcccccaa actcctcatc tatggtaaca gcaatcggcc ctcaggggtc      180

cctgaccgat tctctggctc caagtctggc acctcagcct ccctggccat cactgggctc      240

caggctgaag atgagactga ttattactgc cagtcctgtg acagcagcct gagtgttgtg      300

gtattcggcg gagggaccaa gctgaccgtc cta                                   333


<210>  246
<211>  8
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P5A-2F11 HCDR1
<222>  (1)..(8)

<400>  246

Gly Tyr Thr Phe Thr Ser Tyr Asp 
1               5               


<210>  247
<211>  8
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P5A-2F11 HCDR2
<222>  (1)..(8)

<400>  247

Met Asn Pro Asn Ser Gly Asn Thr 
1               5               


<210>  248
<211>  15
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P5A-2F11 HCDR3
<222>  (1)..(15)

<400>  248

Ala Arg Tyr Ile Val Val Val Pro Ala Ala Lys Gly Phe Asp Pro 
1               5                   10                  15  


<210>  249
<211>  12
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P5A-2F11 LCDR1
<222>  (1)..(12)

<400>  249

Gln Ser Val Leu Tyr Ser Ser Asn Asn Lys Asn Tyr 
1               5                   10          


<210>  250
<211>  4
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P5A-2F11 LCDR2
<222>  (1)..(3)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa is absent.

<400>  250

Trp Ala Ser Xaa 
1               


<210>  251
<211>  9
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P5A-2F11 LCDR3
<222>  (1)..(9)

<400>  251

Gln Gln Tyr Tyr Ser Thr Pro Leu Thr 
1               5                   


<210>  252
<211>  122
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P5A-2F11 VH
<222>  (1)..(122)

<400>  252

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asp Ile Asn Trp Val Arg Gln Ala Thr Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Met Asn Pro Asn Ser Gly Asn Thr Gly Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asn Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Ile Val Val Val Pro Ala Ala Lys Gly Phe Asp Pro Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  253
<211>  113
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P5A-2F11 VL
<222>  (1)..(113)

<400>  253

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Tyr Ser 
            20                  25                  30          


Ser Asn Asn Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Ser Thr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys 
    


<210>  254
<211>  366
<212>  DNA
<213>  Homo sapiens


<220>
<221>  P5A-2F11 VHnu
<222>  (1)..(366)

<400>  254
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggata caccttcacc agttatgata tcaactgggt gcgacaggcc      120

actggacaag ggcttgagtg gatgggatgg atgaacccta acagtggtaa cacaggctat      180

gcacagaagt tccagggcag agtcaccatg accaggaaca cctccataag cacagcctac      240

atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gagatatatt      300

gtagtagtac cagctgcaaa agggttcgac ccctggggcc agggaaccct ggtcaccgtc      360

tcctca                                                                 366


<210>  255
<211>  339
<212>  DNA
<213>  Homo sapiens


<220>
<221>  P5A-2F11 VLnu
<222>  (1)..(339)

<400>  255
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtgtttta tacagctcca acaataagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagattt cactctcacc      240

atcagcagcc tgcaggctga agatgtggca gtttattact gtcagcaata ttatagtact      300

cctctcactt tcggcggagg gaccaaggtg gagatcaaa                             339


<210>  256
<211>  8
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P5A-2E1 HCDR1
<222>  (1)..(8)

<400>  256

Gly Tyr Ser Phe Thr Ser Tyr Trp 
1               5               


<210>  257
<211>  8
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P5A-2E1 HCDR2
<222>  (1)..(8)

<400>  257

Ile Tyr Pro Gly Asp Ser Asp Thr 
1               5               


<210>  258
<211>  12
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P5A-2E1 HCDR3
<222>  (1)..(12)

<400>  258

Ala Gln Thr Ser Val Thr Arg Asn Trp Phe Asp Pro 
1               5                   10          


<210>  259
<211>  6
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P5A-2E1 LCDR1
<222>  (1)..(6)

<400>  259

Asn Ile Gly Ser Lys Ser 
1               5       


<210>  260
<211>  4
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P5A-2E1 LCDR2
<222>  (1)..(3)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa is absent.

<400>  260

Tyr Asp Ser Xaa 
1               


<210>  261
<211>  11
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P5A-2E1 LCDR3
<222>  (1)..(11)

<400>  261

Gln Val Trp Asp Ser Ser Ser Asp His Val Val 
1               5                   10      


<210>  262
<211>  119
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P5A-2E1 VH
<222>  (1)..(119)

<400>  262

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Gln Thr Ser Val Thr Arg Asn Trp Phe Asp Pro Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  263
<211>  108
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P5A-2E1 VL
<222>  (1)..(108)

<400>  263

Ser Tyr Val Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Lys 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly Ser Lys Ser Val 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Tyr Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala Gly 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Ser Ser Ser Asp His 
                85                  90                  95      


Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105             


<210>  264
<211>  357
<212>  DNA
<213>  Homo sapiens


<220>
<221>  P5A-2E1 VHnu
<222>  (1)..(357)

<400>  264
gaggtgcagc tggtgcagtc tggagcagag gtgaaaaagc ccggggagtc tctgaagatc       60

tcctgtaagg gttctggata cagctttacc agctactgga tcggctgggt gcgccagatg      120

cccgggaaag gcctggagtg gatggggatc atctatcctg gtgactctga taccagatac      180

agcccgtcct tccaaggcca ggtcaccatc tcagccgaca agtccatcag caccgcctac      240

ctgcagtgga gcagcctgaa ggcctcggac accgccatgt attactgtgc ccagacgtca      300

gtgactcgca actggttcga cccctggggc cagggaaccc tggtcaccgt ctcctca         357


<210>  265
<211>  324
<212>  DNA
<213>  Homo sapiens


<220>
<221>  P5A-2E1 VLnu
<222>  (1)..(324)

<400>  265
tcctatgtgc tgactcagcc accctcagtg tcagtggccc caggaaagac ggccaggatt       60

acctgtgggg gaaacaacat tggaagtaaa agtgtgcact ggtaccagca gaagccaggc      120

caggcccctg tgctggtcat ctattatgat agcgaccggc cctcagggat ccctgagcga      180

ttctctggct ccaactctgg gaacacggcc accctgacca tcagcagggt cgaagccggg      240

gatgaggccg actattactg tcaggtgtgg gatagtagta gtgatcatgt ggtattcggc      300

ggagggacca agctgaccgt ccta                                             324


<210>  266
<211>  8
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P5A-1C8 HCDR1
<222>  (1)..(8)

<400>  266

Gly Tyr Thr Phe Thr Ser Tyr Tyr 
1               5               


<210>  267
<211>  8
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P5A-1C8 HCDR2
<222>  (1)..(8)

<400>  267

Ile Asn Pro Ser Gly Gly Ser Thr 
1               5               


<210>  268
<211>  22
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P5A-1C8 HCDR3
<222>  (1)..(22)

<400>  268

Ala Arg Ser Ala Arg Asp Tyr Tyr Asp Ser Ser Gly Tyr Tyr Tyr Arg 
1               5                   10                  15      


Ala Glu Tyr Phe Gln His 
            20          


<210>  269
<211>  6
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P5A-1C8 LCDR1
<222>  (1)..(6)

<400>  269

Gln Asp Ile Ser Asn Tyr 
1               5       


<210>  270
<211>  4
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P5A-1C8 LCDR2
<222>  (1)..(3)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa is absent.

<400>  270

Asp Ala Ser Xaa 
1               


<210>  271
<211>  10
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P5A-1C8 LCDR3
<222>  (1)..(10)

<400>  271

Gln Gln Tyr Asp Asn Leu Pro Ser Ile Thr 
1               5                   10  


<210>  272
<211>  129
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P5A-1C8 VH
<222>  (1)..(129)

<400>  272

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Ala Arg Asp Tyr Tyr Asp Ser Ser Gly Tyr Tyr Tyr Arg 
            100                 105                 110         


Ala Glu Tyr Phe Gln His Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210>  273
<211>  108
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(108)
<223>  P5A-1C8 VL

<400>  273

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Asn Leu Pro Ser 
                85                  90                  95      


Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
            100                 105             


<210>  274
<211>  387
<212>  DNA
<213>  Homo sapiens


<220>
<221>  P5A-1C8 VHnu
<222>  (1)..(387)

<400>  274
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtt       60

tcctgcaagg catctggata caccttcacc agctactata tgcactgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggaata atcaacccta gtggtggtag cacaagctac      180

gcacagaagt tccagggcag agtcaccatg accagggaca cgtccacgag cacagtctac      240

atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gaggtcggcc      300

cgggattact atgatagtag tggttattac taccgcgctg aatacttcca gcactggggc      360

cagggcaccc tggtcaccgt ctcctca                                          387


<210>  275
<211>  324
<212>  DNA
<213>  Homo sapiens


<220>
<221>  P5A-1C8 VLnu
<222>  (1)..(324)

<400>  275
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc aggcgagtca ggacattagc aactatttaa attggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctacgat gcatccaatt tggaaacagg ggtcccatca      180

aggttcagtg gaagtggatc tgggacagat tttactttca ccatcagcag cctgcagcct      240

gaagatattg caacatatta ctgtcaacag tatgataatc tcccctctat caccttcggc      300

caagggacac gactggagat taaa                                             324


<210>  276
<211>  8
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P1A-1C10 HCDR1
<222>  (1)..(8)

<400>  276

Gly Gly Thr Ser Ser Phe Tyr Asp 
1               5               


<210>  277
<211>  8
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P1A-1C10 HCDR2
<222>  (1)..(8)

<400>  277

Ile Ile Pro Arg Leu Asp Ile Ala 
1               5               


<210>  278
<211>  16
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P1A-1C10 HCDR3
<222>  (1)..(16)

<400>  278

Ala Arg Gly Arg Pro Gly Ser Glu Trp Ala Tyr Gly Pro Phe Asp Leu 
1               5                   10                  15      


<210>  279
<211>  6
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P1A-1C10 KCDR1
<222>  (1)..(6)

<400>  279

Gln Ser Ser Arg Ala Trp 
1               5       


<210>  280
<211>  4
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P1A-1C10 KCDR2
<222>  (1)..(3)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa is absent.

<400>  280

Lys Ala Ser Xaa 
1               


<210>  281
<211>  9
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P1A-1C10 KCDR3
<222>  (1)..(9)

<400>  281

His Gln Tyr Asn Ser Ser Pro Phe Thr 
1               5                   


<210>  282
<211>  123
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P1A-1C10 VH
<222>  (1)..(123)

<400>  282

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Asn Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Gly Gly Gly Thr Ser Ser Phe Tyr 
            20                  25                  30          


Asp Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Lys Ile Ile Pro Arg Leu Asp Ile Ala Asp Tyr Ala Gln Lys Ser 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Leu Glu Leu Ser Ser Leu Lys Ser Asp Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gly Arg Pro Gly Ser Glu Trp Ala Tyr Gly Pro Phe Asp Leu 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  283
<211>  107
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P1A-1C10 VL
<222>  (1)..(107)

<400>  283

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ser Arg Ala Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Ser Lys Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Tyr Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Ser Ala Thr Tyr Tyr Cys His Gln Tyr Asn Ser Ser Pro Phe 
                85                  90                  95      


Thr Phe Gly Pro Gly Thr Lys Val Gln Ile Lys 
            100                 105         


<210>  284
<211>  369
<212>  DNA
<213>  Homo sapiens


<220>
<221>  P1A-1C10 VHnu
<222>  (1)..(369)

<400>  284
caggtgcagc tggtgcagtc tggggctgag gtgaagaacc cggggtcctc ggtgaaggtc       60

tcctgtaagg ctggtggagg cacctccagt ttctatgata tcaactgggt gcgacaggcc      120

cctggacaag ggcttgagtg gataggaaaa atcatcccta ggcttgatat agcagactac      180

gcacagaagt cccagggcag agtcacgatt accgcggaca aatccacgag tacagtatac      240

ttggaattga gcagcctgaa gtcagacgac acggccgtgt atttctgtgc gagaggtcgg      300

ccgggttcgg agtgggcgta tggcccattt gacctctggg gccagggaac cctggtcacc      360

gtctcctca                                                              369


<210>  285
<211>  321
<212>  DNA
<213>  Homo sapiens


<220>
<221>  P1A-1C10 Vlnu
<222>  (1)..(321)

<400>  285
gacatccaga tgacccagtc tccttccacc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggccagtca gagttctagg gcctggttgg cctggtatca gcagaaacca      120

gggaaagccc ctaaactcct gatctctaag gcgtctagtt tagaaagtgg ggtcccatca      180

aggttcagcg gcagtggata tgggacagaa ttcactctca ccatcagcag cctgcagcct      240

gatgattctg caacttatta ctgccaccag tataacagta gcccattcac tttcggccct      300

gggaccaaag tgcagatcaa a                                                321


<210>  286
<211>  8
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P4A-1H6 HCDR1
<222>  (1)..(8)

<400>  286

Gly Phe Thr Phe Ser Ser Tyr Gly 
1               5               


<210>  287
<211>  8
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P4A-1H6 HCDR2
<222>  (1)..(8)

<400>  287

Ile Ser Asp Asp Gly Ser Asn Gln 
1               5               


<210>  288
<211>  21
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P4A-1H6 HCDR3
<222>  (1)..(21)

<400>  288

Ala Lys Arg Gly Gly Tyr Cys Ser Thr Thr Ser Cys Leu Leu Arg Trp 
1               5                   10                  15      


Val Tyr Phe Asp Phe 
            20      


<210>  289
<211>  6
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P4A-1H6 LCDR1
<222>  (1)..(6)

<400>  289

Gln Ser Ile Ser Ser Tyr 
1               5       


<210>  290
<211>  4
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P4A-1H6 LCDR2
<222>  (1)..(3)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa is absent

<400>  290

Ala Ala Ser Xaa 
1               


<210>  291
<211>  8
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P4A-1H6 LCDR3
<222>  (1)..(8)

<400>  291

Gln Gln Ser Tyr Asn Thr Pro Thr 
1               5               


<210>  292
<211>  128
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P4A-1H6 VH
<222>  (1)..(128)

<400>  292

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Asp Asp Gly Ser Asn Gln Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Val Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Arg Gly Gly Tyr Cys Ser Thr Thr Ser Cys Leu Leu Arg Trp 
            100                 105                 110         


Val Tyr Phe Asp Phe Trp Gly Gln Gly Thr Leu Ala Thr Val Ser Ser 
        115                 120                 125             


<210>  293
<211>  106
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P4A-1H6 VL
<222>  (1)..(106)

<400>  293

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Asn Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Asn Thr Pro Thr 
                85                  90                  95      


Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 
            100                 105     


<210>  294
<211>  384
<212>  DNA
<213>  Homo sapiens


<220>
<221>  P4A-1H6 VHnu
<222>  (1)..(384)

<400>  294
caggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt agctatggca tgcactgggt ccgccagtct      120

ccaggcaagg ggctggagtg ggtggcagtt atatcagatg atggaagtaa tcaatactat      180

gcagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agttgaggac acggctgtgt attactgtgc gaaaaggggc      300

ggatattgta gtactaccag ctgcctcctt aggtgggtct actttgactt ctggggccag      360

ggaaccctgg ccaccgtctc ctca                                             384


<210>  295
<211>  318
<212>  DNA
<213>  Homo sapiens


<220>
<221>  P4A-1H6 Vlnu
<222>  (1)..(318)

<400>  295
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggcaagtca gagcattagc agctatttac attggtatca gcaaaaacca      120

gggaaagccc ctaacctcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca      180

aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct      240

gaagactttg caacttacta ctgtcaacag agttacaata cccctacttt cggccctggg      300

accaaagtgg atatcaaa                                                    318


<210>  296
<211>  8
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P4B-1F4 HCDR1
<222>  (1)..(8)

<400>  296

Gly Phe Thr Phe Ser Ser Tyr Gly 
1               5               


<210>  297
<211>  8
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P4B-1F4 HCDR2
<222>  (1)..(8)

<400>  297

Ile Ser Tyr Asp Gly Ser Asn Lys 
1               5               


<210>  298
<211>  22
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P4B-1F4 HCDR3
<222>  (1)..(22)

<400>  298

Ala Lys Gly Pro Arg Tyr Ser Ser Ser Trp Tyr Ile Ser Leu Tyr Tyr 
1               5                   10                  15      


Tyr Tyr Gly Met Asp Val 
            20          


<210>  299
<211>  11
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P4B-1F4 LCDR1
<222>  (1)..(11)

<400>  299

Gln Ser Leu Val Tyr Ser Asp Gly Asn Thr Tyr 
1               5                   10      


<210>  300
<211>  4
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P4B-1F4 LCDR2
<222>  (1)..(3)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa is absent.

<400>  300

Lys Val Ser Xaa 
1               


<210>  301
<211>  10
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P4B-1F4 LCDR3
<222>  (1)..(10)

<400>  301

Met Gln Ala Thr His Trp Pro Leu Tyr Thr 
1               5                   10  


<210>  302
<211>  129
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P4B-1F4 VH
<222>  (1)..(129)

<400>  302

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Ile Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Pro Arg Tyr Ser Ser Ser Trp Tyr Ile Ser Leu Tyr Tyr 
            100                 105                 110         


Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210>  303
<211>  113
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P4B-1F4 VL
<222>  (1)..(113)

<400>  303

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val Tyr Ser 
            20                  25                  30          


Asp Gly Asn Thr Tyr Leu Asn Trp Phe Gln Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Arg Leu Ile Tyr Lys Val Ser Asn Arg Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala 
                85                  90                  95      


Thr His Trp Pro Leu Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  304
<211>  387
<212>  DNA
<213>  Homo sapiens


<220>
<221>  P4B-1F4 VHnu
<222>  (1)..(387)

<400>  304
caggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt agctatggca tgcactgggt ccgccaggct      120

ccaggcaagg ggctggagtg ggtggcagtt atatcatatg atggaagtaa taaatactat      180

gcagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatca acagcctgag agctgaggac acggctgtgt attactgtgc gaaagggcct      300

cggtatagca gcagctggta cataagcctt tactactact acggtatgga cgtctggggc      360

caagggacca cggtcaccgt ctcctca                                          387


<210>  305
<211>  339
<212>  DNA
<213>  Homo sapiens


<220>
<221>  P4B-1F4 Vlnu
<222>  (1)..(339)

<400>  305
gatgttgtga tgactcagtc tccactctcc ctgcccgtca cccttggaca gccggcctcc       60

atctcctgca ggtctagtca aagcctcgta tacagtgatg gaaacaccta cttgaattgg      120

tttcagcaga ggccaggcca atctccaagg cgcctaattt ataaggtttc taaccgggac      180

tctggggtcc cagacagatt cagcggcagt gggtcaggca ctgatttcac actgaaaatc      240

agcagggtgg aggctgagga tgttggggtt tattactgca tgcaagctac acactggccc      300

ctgtacactt ttggccaggg gaccaagctg gagatcaaa                             339


<210>  306
<211>  8
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P5A-1B6 HCDR1
<222>  (1)..(8)

<400>  306

Gly Phe Thr Phe Ser Ser Tyr Ala 
1               5               


<210>  307
<211>  8
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P5A-1B6 HCDR2
<222>  (1)..(8)

<400>  307

Ile Ser Tyr Asp Gly Ser Asn Lys 
1               5               


<210>  308
<211>  20
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P5A-1B6 HCDR3
<222>  (1)..(20)

<400>  308

Ala Arg Asp Gly Gln Ala Ile Thr Met Val Gln Gly Val Ile Gly Pro 
1               5                   10                  15      


Pro Phe Asp Tyr 
            20  


<210>  309
<211>  6
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P5A-1B6 LCDR1
<222>  (1)..(6)

<400>  309

Gln Asp Ile Ser Asn Tyr 
1               5       


<210>  310
<211>  4
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P5A-1B6 LCDR2
<222>  (1)..(3)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa is absent.

<400>  310

Asp Ala Ser Xaa 
1               


<210>  311
<211>  9
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P5A-1B6 LCDR3
<222>  (1)..(9)

<400>  311

Gln Gln Tyr Asp Asn Leu Pro Tyr Thr 
1               5                   


<210>  312
<211>  127
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P5A-1B6 VH
<222>  (1)..(127)

<400>  312

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Gln Ala Ile Thr Met Val Gln Gly Val Ile Gly Pro 
            100                 105                 110         


Pro Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125         


<210>  313
<211>  107
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P5A-1B6 VL
<222>  (1)..(107)

<400>  313

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Asn Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  314
<211>  381
<212>  DNA
<213>  Homo sapiens


<220>
<221>  P5A-1B6 VHnu
<222>  (1)..(381)

<400>  314
caggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt agctatgcta tgcactgggt ccgccaggct      120

ccaggcaagg ggctggagtg ggtggcagtt atatcatatg atggaagtaa taaatactac      180

gcagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agctgaggac acggctgtgt attactgtgc gagagatgga      300

caggctatta ctatggttca gggagttatc ggcccaccct ttgactactg gggccaggga      360

accctggtca ccgtctcctc a                                                381


<210>  315
<211>  321
<212>  DNA
<213>  Homo sapiens


<220>
<221>  P5A-1B6 Vlnu
<222>  (1)..(321)

<400>  315
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc aggcgagtca ggacattagc aactatttaa attggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctacgat gcatccaatt tggaaacagg ggtcccatca      180

aggttcagtg gaagtggatc tgggacagat tttactttca ccatcagcag cctgcagcct      240

gaagatattg caacatatta ctgtcaacag tatgataatc tcccgtacac ttttggccag      300

gggaccaagc tggagatcaa a                                                321


<210>  316
<211>  8
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P5A-1B8 HCDR1
<222>  (1)..(8)

<400>  316

Gly Phe Thr Val Ser Ser Asn Tyr 
1               5               


<210>  317
<211>  7
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P5A-1B8 HCDR2
<222>  (1)..(7)

<400>  317

Ile Tyr Pro Gly Gly Ser Thr 
1               5           


<210>  318
<211>  9
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P5A-1B8 HCDR3
<222>  (1)..(9)

<400>  318

Ala Arg Glu Thr Leu Ala Phe Asp Tyr 
1               5                   


<210>  319
<211>  6
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P5A-1B8 LCDR1
<222>  (1)..(6)

<400>  319

Gln Gly Ile Ser Ser Tyr 
1               5       


<210>  320
<211>  4
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P5A-1B8 LCDR2
<222>  (1)..(3)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa is absent.

<400>  320

Ala Ala Ser Xaa 
1               


<210>  321
<211>  9
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P5A-1B8 LCDR3
<222>  (1)..(9)

<400>  321

Gln Gln Leu Asn Ser Tyr Pro Pro Ala 
1               5                   


<210>  322
<211>  115
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P5A-1B8 VH
<222>  (1)..(115)

<400>  322

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ile Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ser Asn 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Tyr Pro Gly Gly Ser Thr Phe Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Glu Thr Leu Ala Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  323
<211>  107
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P5A-1B8 VL
<222>  (1)..(107)

<400>  323

Asp Ile Gln Leu Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Leu Asn Ser Tyr Pro Pro 
                85                  90                  95      


Ala Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  324
<211>  345
<212>  DNA
<213>  Homo sapiens


<220>
<221>  P5A-1B8 VHnu
<222>  (1)..(345)

<400>  324
gaggtgcagc tggtggagtc tggaggaggc ttgatccagc ctggggggtc cctgagactc       60

tcctgtgcag cctctgggtt caccgtcagt agcaactaca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcagtt atttatcccg gtggtagcac attctacgca      180

gactccgtga agggccgatt caccatctcc agagacaatt ccaagaacac cctgtatctt      240

caaatgaaca gcctgagagc cgaggacacg gccgtgtatt actgtgcgag agagacccta      300

gcctttgact actggggcca gggaaccctg gtcaccgtct cctca                      345


<210>  325
<211>  321
<212>  DNA
<213>  Homo sapiens


<220>
<221>  P5A-1B8 Vlnu
<222>  (1)..(321)

<400>  325
gacatccagt tgacccagtc tccatccttc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggccagtca gggcattagc agttatttag cctggtatca gcaaaaacca      120

gggaaagccc ctaagctcct gatctatgct gcatccactt tgcaaagtgg ggtcccatca      180

aggttcagcg gcagtggatc tgggacagaa ttcactctca caatcagcag cctgcagcct      240

gaagattttg caacttatta ctgtcaacag cttaatagtt accctccagc tttcggcgga      300

gggaccaagg tggagatcaa a                                                321


<210>  326
<211>  8
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P5A-1B9 HCDR1
<222>  (1)..(8)

<400>  326

Gly Gly Ser Ile Ser Ser Tyr Tyr 
1               5               


<210>  327
<211>  7
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P5A-1B9 HCDR2
<222>  (1)..(7)

<400>  327

Ile Ser Tyr Ser Gly Ser Thr 
1               5           


<210>  328
<211>  22
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P5A-1B9 HCDR3
<222>  (1)..(22)

<400>  328

Ala Ser Asn Gly Gln Tyr Tyr Asp Ile Leu Thr Gly Gln Pro Pro Asp 
1               5                   10                  15      


Tyr Trp Tyr Phe Asp Leu 
            20          


<210>  329
<211>  12
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P5A-1B9 LCDR1
<222>  (1)..(12)

<400>  329

Gln Ser Val Leu Tyr Ser Ser Asn Asn Lys Asn Tyr 
1               5                   10          


<210>  330
<211>  4
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P5A-1B9 LCDR2
<222>  (1)..(3)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa is absent.

<400>  330

Trp Ala Ser Xaa 
1               


<210>  331
<211>  9
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P5A-1B9 LCDR3
<222>  (1)..(9)

<400>  331

Gln Gln Tyr Tyr Ser Thr Pro Leu Thr 
1               5                   


<210>  332
<211>  128
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P5A-1B9 VH
<222>  (1)..(128)

<400>  332

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Tyr 
            20                  25                  30          


Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Ser Tyr Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Leu Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ser Asn Gly Gln Tyr Tyr Asp Ile Leu Thr Gly Gln Pro Pro Asp Tyr 
            100                 105                 110         


Trp Tyr Phe Asp Leu Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125             


<210>  333
<211>  113
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P5A-1B9 VL
<222>  (1)..(113)

<400>  333

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Tyr Ser 
            20                  25                  30          


Ser Asn Asn Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Ser Thr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys 
    


<210>  334
<211>  384
<212>  DNA
<213>  Homo sapiens


<220>
<221>  P5A-1B9 VHnu
<222>  (1)..(384)

<400>  334
caggtgcagc tgcaggagtc gggcccagga ctggtgaagc cttcggagac cctgtccctc       60

acctgcactg tctctggtgg ctccatcagt agttactact ggagctggat ccggcagccc      120

ccagggaagg gactggagtg gattgggtat atctcttaca gtgggagcac caactacaac      180

ccctccctca agagtcgagt caccatatca ctagacacgt ccaagaacca gttctccctg      240

aagctgagct ctgtgaccgc tgcggacacg gccgtgtatt actgtgcgag caacggccag      300

tattacgata ttttgactgg tcaacctcct gactactggt acttcgatct ctggggccgt      360

ggcaccctgg tcactgtctc ctca                                             384


<210>  335
<211>  339
<212>  DNA
<213>  Homo sapiens


<220>
<221>  P5A-1B9 Vlnu
<222>  (1)..(339)

<400>  335
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtgtttta tacagctcca acaataagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagattt cactctcacc      240

atcagcagcc tgcaggctga agatgtggca gtttattact gtcagcaata ttatagtact      300

ccgctcactt tcggcggagg gaccaaggtg gagatcaaa                             339


<210>  336
<211>  8
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P5A-1D1 HCDR1
<222>  (1)..(8)

<400>  336

Gly Leu Thr Val Ser Ser Asn Tyr 
1               5               


<210>  337
<211>  7
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P5A-1D1 HCDR2
<222>  (1)..(7)

<400>  337

Ile Tyr Ser Gly Gly Ser Thr 
1               5           


<210>  338
<211>  11
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P5A-1D1 HCDR3
<222>  (1)..(11)

<400>  338

Ala Arg Asp Leu Tyr Tyr Tyr Gly Met Asp Val 
1               5                   10      


<210>  339
<211>  6
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P5A-1D1 LCDR1
<222>  (1)..(6)

<400>  339

Gln Gly Ile Ser Ser Tyr 
1               5       


<210>  340
<211>  4
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P5A-1D1 LCDR2
<222>  (1)..(3)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa is absent.

<400>  340

Ala Ala Ser Xaa 
1               


<210>  341
<211>  8
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P5A-1D1 LCDR3
<222>  (1)..(8)

<400>  341

Gln Gln Leu Asn Ser Tyr Pro Thr 
1               5               


<210>  342
<211>  117
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P5A-1D1 VH
<222>  (1)..(117)

<400>  342

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ile Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Val Ser Ser Asn 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Tyr Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Leu Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Val Thr Val Ser Thr 
        115         


<210>  343
<211>  106
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P5A-1D1 VL
<222>  (1)..(106)

<400>  343

Asp Ile Gln Leu Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Leu Asn Ser Tyr Pro Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
            100                 105     


<210>  344
<211>  351
<212>  DNA
<213>  Homo sapiens


<220>
<221>  P5A-1D1 VHnu
<222>  (1)..(351)

<400>  344
gaggtgcagc tggtggagtc tggaggaggc ttgatccagc ctggggggtc cctgagactc       60

tcctgtgcag cctctgggct caccgtcagt agcaactaca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcagtt atttatagcg gtggtagcac atactacgca      180

gactccgtga agggccgatt caccatctcc agagacaatt ccaagaacac gctgtatctt      240

caaatgaaca gcctgagagc cgaggacacg gccgtgtatt actgtgcgag agatttgtac      300

tactacggta tggacgtctg gggccaaggg accacggtca ccgtctccac a               351


<210>  345
<211>  318
<212>  DNA
<213>  Homo sapiens


<220>
<221>  P5A-1D1 Vlnu
<222>  (1)..(318)

<400>  345
gacatccagt tgacccagtc tccatccttc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggccagtca gggcattagc agttatttag cctggtatca gcaaaaacca      120

gggaaagccc ctaagctcct gatctatgct gcatccactt tgcaaagtgg ggtcccatca      180

aggttcagcg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct      240

gaagattttg caacttatta ctgtcaacag cttaatagtt accctacctt cggccaaggg      300

acacgactgg agattaaa                                                    318


<210>  346
<211>  8
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P5A-1D10 HCDR1
<222>  (1)..(8)

<400>  346

Gln Phe Thr Phe Ser Asp Tyr Ser 
1               5               


<210>  347
<211>  8
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P5A-1D10 HCDR2
<222>  (1)..(8)

<400>  347

Ile Ser Gln Ser Gly Ser Thr Ile 
1               5               


<210>  348
<211>  21
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P5A-1D10 HCDR3
<222>  (1)..(21)

<400>  348

Ala Arg Gly Val Ser Pro Ser Tyr Val Trp Gly Ser Tyr Arg Ser Leu 
1               5                   10                  15      


Tyr His Phe Asp Tyr 
            20      


<210>  349
<211>  9
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P5A-1D10 LCDR1
<222>  (1)..(9)

<400>  349

Ser Ser Asp Val Gly Gly Tyr Asn Tyr 
1               5                   


<210>  350
<211>  4
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P5A-1D10 LCDR2
<222>  (1)..(3)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa is absent.

<400>  350

Asp Val Ser Xaa 
1               


<210>  351
<211>  11
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P5A-1D10 LCDR3
<222>  (1)..(11)

<400>  351

Ser Ser Phe Thr Ser Ser Thr Thr Val Val Val 
1               5                   10      


<210>  352
<211>  128
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P5A-1D10 VH
<222>  (1)..(128)

<400>  352

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gln Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Ser Met Thr Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Gln Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Val Ser Pro Ser Tyr Val Trp Gly Ser Tyr Arg Ser Leu 
            100                 105                 110         


Tyr His Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125             


<210>  353
<211>  111
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P5A-1D10 VL
<222>  (1)..(111)

<400>  353

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Asp Val Ser Asn Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Ala Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Phe Thr Ser Ser 
                85                  90                  95      


Thr Thr Val Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110     


<210>  354
<211>  384
<212>  DNA
<213>  Homo sapiens


<220>
<221>  P5A-1D10 VHnu
<222>  (1)..(384)

<400>  354
caggtgcagc tggtggagtc tgggggaggc ttggtcaagc ctggagggtc cctgagactc       60

tcctgtgcag cctctcaatt caccttcagt gactactcca tgacctggat ccgccaggct      120

ccagggaagg ggctggagtg ggtttcatac attagtcaaa gtggtagtac catatactac      180

gcagactctg tgaagggccg attcaccatc tccagggaca acgccaagaa ctcactgtat      240

ctgcaaatga acagcctgag agccgaggac acggccgtgt attactgtgc gagaggtgtc      300

agcccatcct acgtttgggg gagttatcgt tccttgtacc actttgacta ctggggccag      360

ggaaccctgg tcaccgtctc ctca                                             384


<210>  355
<211>  333
<212>  DNA
<213>  Homo sapiens


<220>
<221>  P5A-1D10 Vlnu
<222>  (1)..(333)

<400>  355
cagtctgccc tgactcagcc tgcctccgtg tctgggtctc ctggacagtc gatcaccatc       60

tcctgcactg gaaccagcag tgacgttggt ggttataact atgtctcctg gtaccaacaa      120

cacccaggca aagcccccaa actcatgatt tatgatgtca gtaatcggcc ctcaggggtt      180

tctaatcgct tctctgcctc caagtctggc aacacggcct ccctgaccat ctctgggctc      240

caggctgagg acgaggctga ttattactgc agctcattta caagcagcac cactgtcgtg      300

gtattcggcg gagggaccaa gctgaccgtc cta                                   333


<210>  356
<211>  8
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P5A-2D11 HCDR1
<222>  (1)..(8)

<400>  356

Gly Tyr Ser Phe Thr Ser Tyr Trp 
1               5               


<210>  357
<211>  8
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P5A-2D11 HCDR2
<222>  (1)..(8)

<400>  357

Ile Tyr Pro Gly Asp Ser Asp Thr 
1               5               


<210>  358
<211>  13
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P5A-2D11 HCDR3
<222>  (1)..(13)

<400>  358

Ala Arg Arg Asp Ser Thr Tyr Gly Gly Asn Thr Asp Tyr 
1               5                   10              


<210>  359
<211>  8
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P5A-2D11 LCDR1
<222>  (1)..(8)

<400>  359

Ser Ser Asn Ile Gly Ser Asn Thr 
1               5               


<210>  360
<211>  4
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P5A-2D11 LCDR2
<222>  (1)..(3)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa is absent.

<400>  360

Ser Asn Asn Xaa 
1               


<210>  361
<211>  11
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P5A-2D11 LCDR3
<222>  (1)..(11)

<400>  361

Ala Ala Trp Asp Asp Ser Leu Asn Gly Val Val 
1               5                   10      


<210>  362
<211>  120
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P5A-2D11 VH
<222>  (1)..(120)

<400>  362

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Asp Ser Thr Tyr Gly Gly Asn Thr Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  363
<211>  110
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P5A-2D11 VL
<222>  (1)..(110)

<400>  363

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 
            20                  25                  30          


Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Asn Gly Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  364
<211>  360
<212>  DNA
<213>  Homo sapiens


<220>
<221>  P5A-2D11 VHnu
<222>  (1)..(360)

<400>  364
gaggtgcagc tggtgcagtc tggagcagag gtgaaaaagc ccggggagtc tctgaagatc       60

tcctgtaagg gttctggata cagctttacc agctactgga tcggctgggt gcgccagatg      120

cccgggaaag gcctggagtg gatggggatc atctatcctg gtgactctga taccagatac      180

agcccgtcct tccaaggcca ggtcaccatc tcagccgaca agtccatcag caccgcctac      240

ctgcagtgga gcagcctgaa ggcctcggac accgccatgt attactgtgc gagacgggat      300

tcgacctacg gtggtaacac tgactactgg ggccagggaa ccctggtcac cgtctcctca      360


<210>  365
<211>  330
<212>  DNA
<213>  Homo sapiens


<220>
<221>  P5A-2D11 Vlnu
<222>  (1)..(330)

<400>  365
cagtctgtgc tgactcagcc accctcagcg tctgggaccc ccgggcagag ggtcaccatc       60

tcttgttctg gaagcagctc caacatcgga agtaatactg taaactggta ccagcagctc      120

ccaggaacgg cccccaaact cctcatctat agtaataatc agcggccctc aggggtccct      180

gaccgattct ctggctccaa gtctggcacc tcagcctccc tggccatcag tgggctccag      240

tctgaggatg aggctgatta ttactgtgca gcatgggatg acagcctgaa tggtgtggta      300

ttcggcggag ggaccaagct gaccgtccta                                       330


<210>  366
<211>  8
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P5A-2G9 HCDR1
<222>  (1)..(8)

<400>  366

Gly Phe Thr Phe Ser Ser Tyr Gly 
1               5               


<210>  367
<211>  8
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P5A-2G9 HCDR2
<222>  (1)..(8)

<400>  367

Ile Trp Tyr Asp Gly Ser Asn Lys 
1               5               


<210>  368
<211>  12
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P5A-2G9 HCDR3
<222>  (1)..(12)

<400>  368

Ala Arg Trp Phe His Thr Gly Gly Tyr Phe Asp Tyr 
1               5                   10          


<210>  369
<211>  9
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P5A-2G9 LCDR1
<222>  (1)..(9)

<400>  369

Ser Asp Ile Asn Val Ser Ser Tyr Asn 
1               5                   


<210>  370
<211>  7
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P5A-2G9 LCDR2
<222>  (1)..(7)

<400>  370

Tyr Tyr Ser Asp Ser Asp Lys 
1               5           


<210>  371
<211>  10
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P5A-2G9 LCDR3
<222>  (1)..(10)

<400>  371

Met Ile Trp Pro Ser Asn Ala Leu Tyr Val 
1               5                   10  


<210>  372
<211>  119
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P5A-2G9 VH
<222>  (1)..(119)

<400>  372

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Trp Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Phe His Thr Gly Gly Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  373
<211>  116
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P5A-2G9 VL
<222>  (1)..(116)

<400>  373

Gln Pro Val Leu Thr Gln Pro Pro Ser Ser Ser Ala Ser Pro Gly Glu 
1               5                   10                  15      


Ser Ala Arg Leu Thr Cys Thr Leu Pro Ser Asp Ile Asn Val Ser Ser 
            20                  25                  30          


Tyr Asn Ile Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Pro Pro Arg Tyr 
        35                  40                  45              


Leu Leu Tyr Tyr Tyr Ser Asp Ser Asp Lys Gly Gln Gly Ser Gly Val 
    50                  55                  60                  


Pro Ser Arg Phe Ser Gly Ser Lys Asp Ala Ser Ala Asn Thr Gly Ile 
65                  70                  75                  80  


Leu Leu Ile Ser Gly Leu Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys 
                85                  90                  95      


Met Ile Trp Pro Ser Asn Ala Leu Tyr Val Phe Gly Thr Gly Thr Lys 
            100                 105                 110         


Val Thr Val Leu 
        115     


<210>  374
<211>  357
<212>  DNA
<213>  Homo sapiens


<220>
<221>  P5A-2G9 VHnu
<222>  (1)..(357)

<400>  374
caggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc       60

tcctgtgcag cgtctggatt caccttcagt agctatggca tgcactgggt ccgccaggct      120

ccaggcaagg ggctggagtg ggtggcagtt atatggtatg atggaagtaa taaatactat      180

gcagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agccgaggac acggctgtgt attactgtgc gagatggttc      300

cacacggggg ggtactttga ctactggggc cagggaaccc tggtcaccgt ctcctca         357


<210>  375
<211>  348
<212>  DNA
<213>  Homo sapiens


<220>
<221>  P5A-2G9 Vlnu
<222>  (1)..(348)

<400>  375
cagcctgtgc tgactcagcc accttcctcc tccgcatctc ctggagaatc cgccagactc       60

acctgcacct tgcccagtga catcaatgtt agtagctaca acatatactg gtaccagcag      120

aagccaggga gccctcccag gtatctcctg tactactact cagactcaga taagggccag      180

ggctctggag tccccagccg cttctctgga tccaaagatg cttcagccaa tacagggatt      240

ttactcatct ccgggctcca gtctgaggat gaggctgact attactgtat gatttggcca      300

agcaatgctc tttatgtctt cggaactggg accaaggtca ccgtccta                   348


<210>  376
<211>  8
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P5A-2H3 HCDR1
<222>  (1)..(8)

<400>  376

Gly Tyr Ser Phe Thr Ser Tyr Trp 
1               5               


<210>  377
<211>  8
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P5A-2H3 HCDR2
<222>  (1)..(8)

<400>  377

Ile Tyr Pro Gly Asp Ser Asp Thr 
1               5               


<210>  378
<211>  13
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P5A-2H3 HCDR3
<222>  (1)..(13)

<400>  378

Ala Arg Arg Asp Ser Thr Tyr Gly Gly Asn Thr Asp Tyr 
1               5                   10              


<210>  379
<211>  8
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P5A-2H3 LCDR1
<222>  (1)..(8)

<400>  379

Ser Ser Asn Ile Gly Ser Asn Thr 
1               5               


<210>  380
<211>  4
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P5A-2H3 LCDR2
<222>  (1)..(3)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa is absent.

<400>  380

Ser Asn Asn Xaa 
1               


<210>  381
<211>  11
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P5A-2H3 LCDR3
<222>  (1)..(11)

<400>  381

Ala Ala Trp Asp Asp Ser Leu Asn Gly Val Val 
1               5                   10      


<210>  382
<211>  120
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P5A-2H3 VH
<222>  (1)..(120)

<400>  382

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Glu Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Asp Ser Thr Tyr Gly Gly Asn Thr Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  383
<211>  110
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P5A-2H3 VL
<222>  (1)..(110)

<400>  383

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 
            20                  25                  30          


Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Asn Gly Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  384
<211>  360
<212>  DNA
<213>  Homo sapiens


<220>
<221>  P5A-2H3 VHnu
<222>  (1)..(360)

<400>  384
gaggtgcagc tggtgcagtc tggagcagag gtgaaaaagc ccggggagtc tctgaagatc       60

tcctgtaagg gttctggata cagctttacc agctactgga tcggctgggt gcgccagatg      120

cccgggaaag gcctggagtg gatggggatc atctatcctg gtgactctga taccagatac      180

agcccgtcct tccaaggcca ggtcaccatc tcagccgaga agtccatcag caccgcctac      240

ctgcagtgga gcagcctgaa ggcctcggac accgccatgt attactgtgc gagacgggat      300

tcgacctacg gtggtaacac tgactactgg ggccagggaa ccctggtcac cgtctcctca      360


<210>  385
<211>  330
<212>  DNA
<213>  Homo sapiens


<220>
<221>  P5A-2H3 Vlnu
<222>  (1)..(330)

<400>  385
cagtctgtgc tgactcagcc accctcagcg tctgggaccc ccgggcagag ggtcaccatc       60

tcttgttctg gaagcagctc caacatcgga agtaatactg taaactggta ccagcagctc      120

ccaggaacgg cccccaaact cctcatctat agtaataatc agcggccctc aggggtccct      180

gaccgattct ctggctccaa gtctggcacc tcagcctccc tggccatcag tgggctccag      240

tctgaggatg aggctgatta ttactgtgca gcatgggatg acagcctgaa tggtgtggta      300

ttcggcggag ggaccaagct gaccgtccta                                       330


<210>  386
<211>  8
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P5A-3A1 HCDR1
<222>  (1)..(8)

<400>  386

Gly Phe Thr Val Ser Ser Asn Tyr 
1               5               


<210>  387
<211>  7
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P5A-3A1 HCDR2
<222>  (1)..(7)

<400>  387

Ile Tyr Ser Gly Gly Ser Thr 
1               5           


<210>  388
<211>  11
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P5A-3A1 HCDR3
<222>  (1)..(11)

<400>  388

Ala Arg Asp Tyr Gly Asp Phe Tyr Phe Asp Tyr 
1               5                   10      


<210>  389
<211>  7
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P5A-3A1 LCDR1
<222>  (1)..(7)

<400>  389

Gln Ser Val Ser Ser Ser Tyr 
1               5           


<210>  390
<211>  4
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P5A-3A1 LCDR2
<222>  (1)..(3)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa is absent.

<400>  390

Gly Ala Ser Xaa 
1               


<210>  391
<211>  9
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P5A-3A1 LCDR3
<222>  (1)..(9)

<400>  391

Gln Gln Tyr Gly Ser Ser Pro Arg Thr 
1               5                   


<210>  392
<211>  117
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P5A-3A1 VH
<222>  (1)..(117)

<400>  392

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ile Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ser Asn 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Tyr Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Tyr Gly Asp Phe Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  393
<211>  108
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P5A-3A1 VL
<222>  (1)..(108)

<400>  393

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 
                85                  90                  95      


Arg Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105             


<210>  394
<211>  351
<212>  DNA
<213>  Homo sapiens


<220>
<221>  P5A-3A1 VHnu
<222>  (1)..(351)

<400>  394
gaggtgcagc tggtggagtc tggaggaggc ttgatccagc ctggggggtc cctgagactc       60

tcctgtgcag cctctgggtt caccgtcagt agcaactaca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcagtt atttatagcg gtggtagcac atactacgca      180

gactccgtga agggccgatt caccatctcc agagacaatt ccaagaacac gctgtatctt      240

caaatgaaca gcctgagagc cgaggacacg gccgtgtatt actgtgcgag agactacggt      300

gacttttact ttgactactg gggccaggga accctggtca ccgtctcctc a               351


<210>  395
<211>  324
<212>  DNA
<213>  Homo sapiens


<220>
<221>  P5A-3A1 Vlnu
<222>  (1)..(324)

<400>  395
gaaattgtgt tgacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc       60

ctctcctgca gggccagtca gagtgttagc agcagctact tagcctggta ccagcagaaa      120

cctggccagg ctcccaggct cctcatctat ggtgcatcca gcagggccac tggcatccca      180

gacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagactggag      240

cctgaagatt ttgcagtgta ttactgtcag cagtatggta gctcacctcg cacttttggc      300

caggggacca agctggagat caaa                                             324


<210>  396
<211>  8
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P5A-3A6 HCDR1
<222>  (1)..(8)

<400>  396

Gly Phe Thr Phe Asp Asp Tyr Ala 
1               5               


<210>  397
<211>  8
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P5A-3A6 HCDR2
<222>  (1)..(8)

<400>  397

Ile Ser Trp Asn Ser Gly Thr Ile 
1               5               


<210>  398
<211>  27
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P5A-3A6 HCDR3
<222>  (1)..(27)

<400>  398

Ala Gly Gly Gly Thr Met Val Arg Gly Val Ile Ala Gly Gly Gly Thr 
1               5                   10                  15      


His Pro Val Asp Asp Tyr Tyr Gly Met Asp Val 
            20                  25          


<210>  399
<211>  9
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P5A-3A6 LCDR1
<222>  (1)..(9)

<400>  399

Ser Ser Asp Val Gly Gly Tyr Asn Tyr 
1               5                   


<210>  400
<211>  4
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P5A-3A6 LCDR2
<222>  (1)..(3)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa is absent.

<400>  400

Asp Val Ser Xaa 
1               


<210>  401
<211>  10
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P5A-3A6 LCDR3
<222>  (1)..(10)

<400>  401

Ser Ser Tyr Thr Ser Ser Ser Thr Val Val 
1               5                   10  


<210>  402
<211>  134
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P5A-3A6 VH
<222>  (1)..(134)

<400>  402

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Thr Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Ile Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Gly Gly Gly Thr Met Val Arg Gly Val Ile Ala Gly Gly Gly Thr 
            100                 105                 110         


His Pro Val Asp Asp Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr 
        115                 120                 125             


Thr Val Thr Val Ser Ser 
    130                 


<210>  403
<211>  110
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P5A-3A6 VL
<222>  (1)..(110)

<400>  403

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Asp Val Ser Asn Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Ser Ser 
                85                  90                  95      


Ser Thr Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  404
<211>  402
<212>  DNA
<213>  Homo sapiens


<220>
<221>  P5A-3A6 VHnu
<222>  (1)..(402)

<400>  404
gaagtgcagc tggtggagtc tgggggaggc ttggtacagc ctggcaggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgat gattatgcca tgcactgggt ccggcaagct      120

ccagggaagg gcctggagtg ggtctcaggt attagttgga atagtggtac cataggctat      180

gcggactctg tgaagggccg attcatcatc tccagagaca acgccaagaa ctccctgtat      240

ctgcaaatga acagtctgag agctgaggac acggccttgt attactgtgc agggggtggt      300

actatggttc ggggagttat tgccggaggg ggaactcatc cggtggatga ctactacggt      360

atggacgtct ggggccaagg gaccacggtc accgtctcct ca                         402


<210>  405
<211>  330
<212>  DNA
<213>  Homo sapiens


<220>
<221>  P5A-3A6 Vlnu
<222>  (1)..(330)

<400>  405
cagtctgccc tgactcagcc tgcctccgtg tctgggtctc ctggacagtc gatcaccatc       60

tcctgcactg gaaccagcag tgacgttggt ggttataact atgtctcctg gtaccaacaa      120

cacccaggca aagcccccaa actcatgatt tatgatgtca gtaatcggcc ctcaggggtt      180

tctaatcgct tctctggctc caagtctggc aacacggcct ccctgaccat ctctgggctc      240

caggctgagg acgaggctga ttattactgc agctcatata caagcagcag cactgtggta      300

ttcggcggag ggaccaagct gaccgtccta                                       330


<210>  406
<211>  8
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P5A-3B4 HCDR1
<222>  (1)..(8)

<400>  406

Gly Tyr Ser Phe Thr Ser Tyr Trp 
1               5               


<210>  407
<211>  8
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P5A-3B4 HCDR2
<222>  (1)..(8)

<400>  407

Ile Tyr Pro Gly Asp Ser Asp Thr 
1               5               


<210>  408
<211>  13
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P5A-3B4 HCDR3
<222>  (1)..(13)

<400>  408

Ala Arg Arg Asp Ser Thr Tyr Gly Gly Asn Thr Asp Tyr 
1               5                   10              


<210>  409
<211>  8
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P5A-3B4 LCDR1
<222>  (1)..(8)

<400>  409

Ser Ser Asn Ile Gly Ser Asn Thr 
1               5               


<210>  410
<211>  4
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P5A-3B4 LCDR2
<222>  (1)..(3)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa is absent.

<400>  410

Ser Asn Asn Xaa 
1               


<210>  411
<211>  11
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P5A-3B4 LCDR3
<222>  (1)..(11)

<400>  411

Ala Ala Trp Asp Asp Ser Leu Asn Gly Val Val 
1               5                   10      


<210>  412
<211>  120
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P5A-3B4 VH
<222>  (1)..(120)

<400>  412

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Glu Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Asp Ser Thr Tyr Gly Gly Asn Thr Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  413
<211>  110
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P5A-3B4 VL
<222>  (1)..(110)

<400>  413

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 
            20                  25                  30          


Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Asn Gly Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  414
<211>  360
<212>  DNA
<213>  Homo sapiens


<220>
<221>  P5A-3B4 VHnu
<222>  (1)..(360)

<400>  414
gaggtgcagc tggtgcagtc tggagcagag gtgaaagagc ccggggagtc tctgaagatc       60

tcctgtaagg gttctggata cagctttacc agctactgga tcggctgggt gcgccagatg      120

cccgggaaag gcctggagtg gatggggatc atctatcctg gtgactctga taccagatac      180

agcccgtcct tccaaggcca ggtcaccatc tcagccgaca agtccatcag caccgcctac      240

ctgcagtgga gcagcctgaa ggcctcggac accgccatgt attactgtgc gagacgggat      300

tcgacctacg gtggtaacac tgactactgg ggccagggaa ccctggtcac cgtctcctca      360


<210>  415
<211>  330
<212>  DNA
<213>  Homo sapiens


<220>
<221>  P5A-3B4 Vlnu
<222>  (1)..(330)

<400>  415
cagtctgtgc tgactcagcc accctcagcg tctgggaccc ccgggcagag ggtcaccatc       60

tcttgttctg gaagcagctc caacatcgga agtaatactg taaactggta ccagcagctc      120

ccaggaacgg cccccaaact cctcatctat agtaataatc agcggccctc aggggtccct      180

gaccgattct ctggctccaa gtctggcacc tcagcctccc tggccatcag tgggctccag      240

tctgaggatg aggctgatta ttactgtgca gcatgggatg acagcctgaa tggtgtggta      300

ttcggcggag ggaccaagct gaccgtccta                                       330


<210>  416
<211>  10
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P5A-3C12 HCDR1
<222>  (1)..(10)

<400>  416

Gly Phe Ser Leu Ser Thr Ser Gly Val Gly 
1               5                   10  


<210>  417
<211>  7
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P5A-3C12 HCDR2
<222>  (1)..(7)

<400>  417

Ile Tyr Trp Asp Asp Asp Lys 
1               5           


<210>  418
<211>  19
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P5A-3C12 HCDR3
<222>  (1)..(19)

<400>  418

Ala His Ser Leu Phe Leu Thr Val Gly Tyr Ser Ser Ser Trp Ser Pro 
1               5                   10                  15      


Phe Asp Tyr 
            


<210>  419
<211>  12
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P5A-3C12 LCDR1
<222>  (1)..(12)

<400>  419

Gln Ser Val Leu Tyr Ser Ser Asn Asn Lys Asn Tyr 
1               5                   10          


<210>  420
<211>  4
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P5A-3C12 LCDR2
<222>  (1)..(3)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa is absent.

<400>  420

Trp Ala Ser Xaa 
1               


<210>  421
<211>  9
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P5A-3C12 LCDR3
<222>  (1)..(9)

<400>  421

Gln Gln Tyr Tyr Ser Thr Pro His Thr 
1               5                   


<210>  422
<211>  127
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P5A-3C12 VH
<222>  (1)..(127)

<400>  422

Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 
            20                  25                  30          


Gly Val Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
        35                  40                  45              


Trp Leu Ala Leu Ile Tyr Trp Asp Asp Asp Lys Arg Tyr Ser Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Thr Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  


Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala His Ser Leu Phe Leu Thr Val Gly Tyr Ser Ser Ser Trp Ser 
            100                 105                 110         


Pro Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125         


<210>  423
<211>  113
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P5A-3C12 VL
<222>  (1)..(113)

<400>  423

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Tyr Ser 
            20                  25                  30          


Ser Asn Asn Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Ser Thr Pro His Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  424
<211>  381
<212>  DNA
<213>  Homo sapiens


<220>
<221>  P5A-3C12 VHnu
<222>  (1)..(381)

<400>  424
cagatcacct tgaaggagtc tggtcctacg ctggtgaaac ccacacagac cctcacgctg       60

acctgcacct tctctgggtt ctcactcagc actagtggag tgggtgtggg ctggatccgt      120

cagcccccag gaaaggccct ggagtggctt gcactcattt attgggatga tgataagcgc      180

tacagcccat ctctgaagag caggctcacc atcaccaagg acacctccaa aaaccaggtg      240

gtccttacaa tgaccaacat ggaccctgtg gacacagcca catattactg tgcacacagt      300

ttgtttctca cggtagggta tagcagcagc tggtcccctt ttgactactg gggccaggga      360

accctggtca ccgtctcctc a                                                381


<210>  425
<211>  339
<212>  DNA
<213>  Homo sapiens


<220>
<221>  P5A-3C12 Vlnu
<222>  (1)..(339)

<400>  425
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtgtttta tacagctcca acaataagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagattt cactctcacc      240

atcagcagcc tgcaggctga agatgtggca gtttattact gtcagcaata ttatagtact      300

cctcacactt ttggccaggg gaccaagctg gagatcaaa                             339


<210>  426
<211>  8
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P22A-1D1 HCDR1
<222>  (1)..(8)

<400>  426

Gly Phe Thr Val Ser Ser Asn Tyr 
1               5               


<210>  427
<211>  7
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P22A-1D1 HCDR2
<222>  (1)..(7)

<400>  427

Ile Tyr Ser Gly Gly Ser Thr 
1               5           


<210>  428
<211>  11
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P22A-1D1 HCDR3
<222>  (1)..(11)

<400>  428

Ala Arg Asp Arg Asp Tyr Tyr Gly Met Asp Val 
1               5                   10      


<210>  429
<211>  6
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P22A-1D1 LCDR1
<222>  (1)..(6)

<400>  429

Gln Gly Ile Ser Ser Tyr 
1               5       


<210>  430
<211>  4
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P22A-1D1 LCDR2
<222>  (1)..(3)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa is absent.

<400>  430

Ala Ala Ser Xaa 
1               


<210>  431
<211>  8
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P22A-1D1 LCDR3
<222>  (1)..(8)

<400>  431

Leu His Leu Asn Ser Tyr Arg Thr 
1               5               


<210>  432
<211>  117
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P22A-1D1 VH
<222>  (1)..(117)

<400>  432

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ile Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ser Asn 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Tyr Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Arg Asp Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  433
<211>  106
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P22A-1D1 VL
<222>  (1)..(106)

<400>  433

Asp Ile Gln Leu Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu His Leu Asn Ser Tyr Arg Thr 
                85                  90                  95      


Phe Gly Leu Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210>  434
<211>  351
<212>  DNA
<213>  Homo sapiens


<220>
<221>  P22A-1D1 VHnu
<222>  (1)..(351)

<400>  434
gaggtgcagc tggtggagtc tggaggaggc ttgatccagc ctggggggtc cctgagactc       60

tcctgtgcag cctctgggtt caccgtcagt agcaactaca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcagtt atttatagcg gtggtagcac atactacgca      180

gactccgtga agggccgatt caccatctcc agagacaatt ccaagaacac gctgtatctt      240

caaatgaaca gcctgagagc cgaggacacg gccgtgtatt actgtgcgag agatcgagac      300

tactacggta tggacgtctg gggccaaggg accacggtca ccgtctcctc a               351


<210>  435
<211>  318
<212>  DNA
<213>  Homo sapiens


<220>
<221>  P22A-1D1 Vlnu
<222>  (1)..(318)

<400>  435
gacatccagt tgacccagtc tccatccttc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggccagtca gggcattagc agttatttag cctggtatca gcaaaaacca      120

gggaaagccc ctaagctcct gatctatgct gcatccactt tgcaaagtgg ggtcccatca      180

aggtttagcg gcagtggatc tgggacagaa ttcactctca caatcagcag cctgcagcct      240

gaagattttg caacttatta ctgtctacac cttaatagtt acaggacgtt cggcctaggg      300

accaaggtgg aaatcaaa                                                    318


<210>  436
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P2C-1F11 HCDR1 Based on Kabat Numbering
<222>  (1)..(5)

<400>  436

Ser Asn Tyr Met Asn 
1               5   


<210>  437
<211>  16
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P2C-1F11 HCDR2 Based on Kabat Numbering
<222>  (1)..(16)

<400>  437

Leu Ile Tyr Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly 
1               5                   10                  15      


<210>  438
<211>  9
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P2C-1F11 HCDR3 Based on Kabat Numbering
<222>  (1)..(9)

<400>  438

Asp Leu Val Val Tyr Gly Met Asp Val 
1               5                   


<210>  439
<211>  12
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P2C-1F11 LCDR1 Based on Kabat Numbering
<222>  (1)..(12)

<400>  439

Arg Ala Ser Gln Ser Val Ser Ser Ser Tyr Leu Ala 
1               5                   10          


<210>  440
<211>  7
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P2C-1F11 LCDR2 Based on Kabat Numbering
<222>  (1)..(7)

<400>  440

Gly Ala Ser Ser Arg Ala Thr 
1               5           


<210>  441
<211>  8
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P2C-1F11 LCDR3 Based on Kabat Numbering
<222>  (1)..(8)

<400>  441

Gln Gln Tyr Gly Ser Ser Pro Thr 
1               5               


<210>  442
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P2B-1G5 HCDR1 Based on Kabat Numbering
<222>  (1)..(5)

<400>  442

Thr Tyr Val Met Asn 
1               5   


<210>  443
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P2B-1G5 HCDR2 Based on Kabat Numbering
<222>  (1)..(17)

<400>  443

Trp Ile Asn Thr Asn Thr Gly Asn Pro Thr Tyr Ala Gln Gly Phe Thr 
1               5                   10                  15      


Gly 
    


<210>  444
<211>  10
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P2B-1G5 HCDR3 Based on Kabat Numbering
<222>  (1)..(10)

<400>  444

Glu Ile Thr Thr Leu Gly Gly Met Asp Val 
1               5                   10  


<210>  445
<211>  11
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P2B-1G5 LCDR1 Based on Kabat Numbering
<222>  (1)..(11)

<400>  445

Gly Gly Asn Asn Ile Gly Ser Lys Ser Val His 
1               5                   10      


<210>  446
<211>  7
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P2B-1G5 LCDR2 Based on Kabat Numbering
<222>  (1)..(7)

<400>  446

Tyr Asp Ser Asp Arg Pro Ser 
1               5           


<210>  447
<211>  11
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P2B-1G5 LCDR3 Based on Kabat Numbering
<222>  (1)..(11)

<400>  447

Gln Val Trp Asp Ser Ile Ser Asp His Arg Val 
1               5                   10      


<210>  448
<211>  12
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P2B-1G5 HCDR3 Based on IMGT Numbering
<222>  (1)..(12)

<400>  448

Ser Ser Glu Ile Thr Thr Leu Gly Gly Met Asp Val 
1               5                   10          


<210>  449
<211>  119
<212>  PRT
<213>  Homo sapiens


<220>
<221>  P2B-1G5 VH
<222>  (1)..(119)

<400>  449

Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Thr Tyr 
            20                  25                  30          


Val Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Asn Thr Gly Asn Pro Thr Tyr Ala Gln Gly Phe 
    50                  55                  60                  


Thr Gly Arg Phe Val Phe Ser Leu Asp Thr Ser Val Ser Thr Ala Ser 
65                  70                  75                  80  


Leu Gln Ile Ser Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Ser Glu Ile Thr Thr Leu Gly Gly Met Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser 
        115                 


