                         SEQUENCE LISTING

<110>  Amyris, Inc.
 
<120>  REBAUDIOSIDE M SWEETENER COMPOSITIONS

<130>  5033PCT.1029BS

<150>  62/989,034
<151>  2020-03-13

<160>  15    

<170>  PatentIn version 3.5

<210>  1
<211>  523
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  1

Met Glu Val Thr Val Gly Ser Trp Val Ala Leu Ser Leu Val Phe Val 
1               5                   10                  15      


Ser Ile Ile Val Gly Trp Ala Trp Ser Val Leu Asp Trp Val Trp Leu 
            20                  25                  30          


Lys Pro Lys Lys Leu Glu Arg Cys Leu Arg Glu Gln Gly Leu Lys Gly 
        35                  40                  45              


Asn Ser Tyr Trp Phe Leu Tyr Gly Asp Met Lys Glu Asn Ser Ile Leu 
    50                  55                  60                  


Leu Lys Gln Ala Lys Ser Lys Pro Met Asn Leu Ser Thr Ser His Asp 
65                  70                  75                  80  


Ile Ala Pro Gln Val Ile Pro Phe Val Asp Gln Thr Val Lys Val Tyr 
                85                  90                  95      


Gly Lys Asn Ser Phe Asp Trp Ile Gly Pro Ile Pro Arg Val Asn Ile 
            100                 105                 110         


Met Asn Pro Glu Glu Leu Lys Asp Val Phe Thr Lys Tyr Asp Asp Phe 
        115                 120                 125             


Ile Lys Pro Ile Ser Asn Pro Leu Phe Lys Leu Leu Ala Thr Gly Leu 
    130                 135                 140                 


Ala Asn Tyr Glu Gly Glu Lys Trp Ala Lys His Arg Arg Ile Ile Asn 
145                 150                 155                 160 


Pro Thr Phe His Ser Glu Lys Leu Lys Arg Met Leu Pro Ser Phe His 
                165                 170                 175     


Gln Ser Cys Thr Glu Met Ile Lys Glu Trp Glu Ser Leu Val Ser Lys 
            180                 185                 190         


Glu Gly Ser Ser Cys Glu Leu Asp Val Trp Pro Phe Leu Glu Asn Met 
        195                 200                 205             


Thr Ala Asp Val Ile Ser Arg Thr Ala Phe Gly Thr Ser Tyr Lys Lys 
    210                 215                 220                 


Gly Arg Lys Ile Phe Glu Leu Leu Arg Glu Gln Ala Ile Tyr Ala Thr 
225                 230                 235                 240 


Lys Ala Ile Gln Ser Phe Tyr Ile Pro Gly Trp Arg Phe Leu Pro Thr 
                245                 250                 255     


Lys Met Asn Lys Arg Met Lys Glu Ile Asn Lys Glu Ile Lys Gly Leu 
            260                 265                 270         


Ile Lys Gly Ile Ile Ile Lys Arg Glu His Thr Ile Lys Ala Gly Glu 
        275                 280                 285             


Glu Thr Lys Asp Asp Leu Leu Gly Ala Leu Met Glu Ser Asn Leu Lys 
    290                 295                 300                 


Asp Ile Arg Glu His Gly Lys Asn Asn Lys Asn Phe Gly Met Ser Ile 
305                 310                 315                 320 


Glu Asp Val Ile Glu Glu Cys Lys Leu Phe Tyr Phe Ala Gly Gln Glu 
                325                 330                 335     


Thr Thr Ser Val Leu Leu Val Trp Thr Met Val Leu Leu Gly Gln Asn 
            340                 345                 350         


Gln Asn Trp Gln Asp Arg Ala Arg Gln Glu Ile Leu Gln Val Phe Gly 
        355                 360                 365             


Ser Asn Lys Pro Asp Phe Asp Gly Leu Thr His Leu Lys Val Val Thr 
    370                 375                 380                 


Met Ile Leu Leu Glu Val Leu Arg Leu Tyr Pro Ala Val Ile Glu Leu 
385                 390                 395                 400 


Pro Arg Thr Ile His Lys Lys Thr Gln Leu Gly Lys Phe Ser Leu Pro 
                405                 410                 415     


Glu Gly Val Glu Val Arg Leu Pro Thr Leu Leu Ile His His Asp Lys 
            420                 425                 430         


Glu Leu Trp Gly Asp Asp Ala Asn Glu Phe Lys Pro Glu Arg Phe Ser 
        435                 440                 445             


Glu Gly Val Ser Lys Ala Thr Lys Ser Arg Leu Ser Phe Phe Pro Phe 
    450                 455                 460                 


Gly Gly Gly Pro Arg Ile Cys Ile Gly Gln Asn Phe Ala Met Met Glu 
465                 470                 475                 480 


Ala Lys Leu Ala Leu Val Leu Ile Leu Gln His Phe Thr Phe Glu Leu 
                485                 490                 495     


Ser Pro Ser Tyr Ala His Ala Pro Ser Tyr Arg Ile Thr Leu Gln Pro 
            500                 505                 510         


Gln Tyr Gly Val Pro Ile Ile Leu His Arg Arg 
        515                 520             


<210>  2
<211>  1571
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  2
atggaagtaa ccgttggatc ttgggtagct ttgtccttag tcttcgtttc tattatcgtc       60

ggttgggctt ggtccgtttt agattgggtc tggttgaaac caaagaagtt agaaagatgt      120

ttgagagaac aaggtttaaa gggtaactct tactggttct tgtatggtga catgaaagag      180

aactctattt tgttgaagca agctaagtct aagccaatga acttatctac ctctcacgac      240

atcgccccac aagttattcc atttgtcgac caaactgtca aggtctacgg taagaactct      300

ttcgattgga tcggtcctat tccaagagtc aatatcatga acccagaaga attgaaggat      360

gttttcacca agtacgatga cttcatcaag ccaatttcta accctttgtt caagttgttg      420

gctaccggtt tggctaatta cgaaggtgag aagtgggcta agcacagacg tattatcaac      480

ccaactttcc attctgagaa gttgaaaaga atgttgccat ccttccacca atcttgtact      540

gaaatgatca aggaatggga atctttggtt tctaaggaag gttcttcttg tgagttagac      600

gtctggccat tcttagaaaa catgaccgct gacgttattt ctagaactgc tttcggtact      660

tcttacaaga agggtagaaa gattttcgaa ttgttgagag aacaagctat ttacgccacc      720

aaggctatcc aatcttttta cattccaggt tggcgttttt tgcctactaa aatgaacaag      780

agaatgaagg aaatcaacaa ggagatcaag ggtttgatta agggtatcat catcaaaaga      840

gaacacacta tcaaggctgg tgaagaaact aaggatgact tgttaggtgc tttgatggaa      900

tctaacttga aggacattag agaacacggt aagaacaaca agaacttcgg tatgtctatc      960

gaagacgtta tcgaagagtg taagttgttc tactttgctg gtcaagaaac tacttctgtt     1020

ttgttagttt ggaccatggt tttgttgggt caaaatcaaa actggcaaga tagagctaga     1080

caagaaatct tgcaagtttt tggttctaat aagccagact tcgatggttt gactcacttg     1140

aaagttgtca ccatgatttt attggaagtc ttgagattgt acccagctgt tatcgaattg     1200

ccaagaacca ttcacaagaa gactcaattg ggtaaattct ctttacctga aggtgttgaa     1260

gttagattgc caactttgtt aatccaccat gataaggaat tgtggggtga tgacgctaac     1320

gaattcaagc cagaacgttt ctctgaaggt gtttctaagg ctaccaaatc cagattgtcc     1380

ttttttcctt tcggtggtgg tcctagaatc tgtattggtc aaaactttgc tatgatggaa     1440

gctaaattgg ctttggtttt gattttgcaa cacttcactt tcgaattgtc cccttcctac     1500

gcccatgctc catcctacag aattacctta caacctcaat atggtgtccc tattatcttg     1560

caccgtcgtt a                                                          1571


<210>  3
<211>  320
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  3

Met Leu Thr Ser Ser Lys Ser Ile Glu Ser Phe Pro Lys Asn Val Gln 
1               5                   10                  15      


Pro Tyr Gly Lys His Tyr Gln Asn Gly Leu Glu Pro Val Gly Lys Ser 
            20                  25                  30          


Gln Glu Asp Ile Leu Leu Glu Pro Phe His Tyr Leu Cys Ser Asn Pro 
        35                  40                  45              


Gly Lys Asp Val Arg Thr Lys Met Ile Glu Ala Phe Asn Ala Trp Leu 
    50                  55                  60                  


Lys Val Pro Lys Asp Asp Leu Ile Val Ile Thr Arg Val Ile Glu Met 
65                  70                  75                  80  


Leu His Ser Ala Ser Leu Leu Ile Asp Asp Val Glu Asp Asp Ser Val 
                85                  90                  95      


Leu Arg Arg Gly Val Pro Ala Ala His His Ile Tyr Gly Thr Pro Gln 
            100                 105                 110         


Thr Ile Asn Cys Ala Asn Tyr Val Tyr Phe Leu Ala Leu Lys Glu Ile 
        115                 120                 125             


Ala Lys Leu Asn Lys Pro Asn Met Ile Thr Ile Tyr Thr Asp Glu Leu 
    130                 135                 140                 


Ile Asn Leu His Arg Gly Gln Gly Met Glu Leu Phe Trp Arg Asp Thr 
145                 150                 155                 160 


Leu Thr Cys Pro Thr Glu Lys Glu Phe Leu Asp Met Val Asn Asp Lys 
                165                 170                 175     


Thr Gly Gly Leu Leu Arg Leu Ala Val Lys Leu Met Gln Glu Ala Ser 
            180                 185                 190         


Gln Ser Gly Thr Asp Tyr Thr Gly Leu Val Ser Lys Ile Gly Ile His 
        195                 200                 205             


Phe Gln Val Arg Asp Asp Tyr Met Asn Leu Gln Ser Lys Asn Tyr Ala 
    210                 215                 220                 


Asp Asn Lys Gly Phe Cys Glu Asp Leu Thr Glu Gly Lys Phe Ser Phe 
225                 230                 235                 240 


Pro Ile Ile His Ser Ile Arg Ser Asp Pro Ser Asn Arg Gln Leu Leu 
                245                 250                 255     


Asn Ile Leu Lys Gln Arg Ser Ser Ser Ile Glu Leu Lys Gln Phe Ala 
            260                 265                 270         


Leu Gln Leu Leu Glu Asn Thr Asn Thr Phe Gln Tyr Cys Arg Asp Phe 
        275                 280                 285             


Leu Arg Val Leu Glu Lys Glu Ala Arg Glu Glu Ile Lys Leu Leu Gly 
    290                 295                 300                 


Gly Asn Ile Met Leu Glu Lys Ile Met Asp Val Leu Ser Val Asn Glu 
305                 310                 315                 320 


<210>  4
<211>  736
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  4

Met Glu His Ala Arg Pro Pro Gln Gly Gly Asp Asp Asp Val Ala Ala 
1               5                   10                  15      


Ser Thr Ser Glu Leu Pro Tyr Met Ile Glu Ser Ile Lys Ser Lys Leu 
            20                  25                  30          


Arg Ala Ala Arg Asn Ser Leu Gly Glu Thr Thr Val Ser Ala Tyr Asp 
        35                  40                  45              


Thr Ala Trp Ile Ala Leu Val Asn Arg Leu Asp Gly Gly Gly Glu Arg 
    50                  55                  60                  


Ser Pro Gln Phe Pro Glu Ala Ile Asp Trp Ile Ala Arg Asn Gln Leu 
65                  70                  75                  80  


Pro Asp Gly Ser Trp Gly Asp Ala Gly Met Phe Ile Val Gln Asp Arg 
                85                  90                  95      


Leu Ile Asn Thr Leu Gly Cys Val Val Ala Leu Ala Thr Trp Gly Val 
            100                 105                 110         


His Glu Glu Gln Arg Ala Arg Gly Leu Ala Tyr Ile Gln Asp Asn Leu 
        115                 120                 125             


Trp Arg Leu Gly Glu Asp Asp Glu Glu Trp Met Met Val Gly Phe Glu 
    130                 135                 140                 


Ile Thr Phe Pro Val Leu Leu Glu Lys Ala Lys Asn Leu Gly Leu Asp 
145                 150                 155                 160 


Ile Asn Tyr Asp Asp Pro Ala Leu Gln Asp Ile Tyr Ala Lys Arg Gln 
                165                 170                 175     


Leu Lys Leu Ala Lys Ile Pro Arg Glu Ala Leu His Ala Arg Pro Thr 
            180                 185                 190         


Thr Leu Leu His Ser Leu Glu Gly Met Glu Asn Leu Asp Trp Glu Arg 
        195                 200                 205             


Leu Leu Gln Phe Lys Cys Pro Ala Gly Ser Leu His Ser Ser Pro Ala 
    210                 215                 220                 


Ala Ser Ala Tyr Ala Leu Ser Glu Thr Gly Asp Lys Glu Leu Leu Glu 
225                 230                 235                 240 


Tyr Leu Glu Thr Ala Ile Asn Asn Phe Asp Gly Gly Ala Pro Cys Thr 
                245                 250                 255     


Tyr Pro Val Asp Asn Phe Asp Arg Leu Trp Ser Val Asp Arg Leu Arg 
            260                 265                 270         


Arg Leu Gly Ile Ser Arg Tyr Phe Thr Ser Glu Ile Glu Glu Tyr Leu 
        275                 280                 285             


Glu Tyr Ala Tyr Arg His Leu Ser Pro Asp Gly Met Ser Tyr Gly Gly 
    290                 295                 300                 


Leu Cys Pro Val Lys Asp Ile Asp Asp Thr Ala Met Ala Phe Arg Leu 
305                 310                 315                 320 


Leu Arg Leu His Gly Tyr Asn Val Ser Ser Ser Val Phe Asn His Phe 
                325                 330                 335     


Glu Lys Asp Gly Glu Tyr Phe Cys Phe Ala Gly Gln Ser Ser Gln Ser 
            340                 345                 350         


Leu Thr Ala Met Tyr Asn Ser Tyr Arg Ala Ser Gln Ile Val Phe Pro 
        355                 360                 365             


Gly Asp Asp Asp Gly Leu Glu Gln Leu Arg Ala Tyr Cys Arg Ala Phe 
    370                 375                 380                 


Leu Glu Glu Arg Arg Ala Thr Gly Asn Leu Arg Asp Lys Trp Val Ile 
385                 390                 395                 400 


Ala Asn Gly Leu Pro Ser Glu Val Glu Tyr Ala Leu Asp Phe Pro Trp 
                405                 410                 415     


Lys Ala Ser Leu Pro Arg Val Glu Thr Arg Val Tyr Leu Glu Gln Tyr 
            420                 425                 430         


Gly Ala Ser Glu Asp Ala Trp Ile Gly Lys Gly Leu Tyr Arg Met Thr 
        435                 440                 445             


Leu Val Asn Asn Asp Leu Tyr Leu Glu Ala Ala Lys Ala Asp Phe Thr 
    450                 455                 460                 


Asn Phe Gln Arg Leu Ser Arg Leu Glu Trp Leu Ser Leu Lys Arg Trp 
465                 470                 475                 480 


Tyr Ile Arg Asn Asn Leu Gln Ala His Gly Val Thr Glu Gln Ser Val 
                485                 490                 495     


Leu Arg Ala Tyr Phe Leu Ala Ala Ala Asn Ile Phe Glu Pro Asn Arg 
            500                 505                 510         


Ala Ala Glu Arg Leu Gly Trp Ala Arg Thr Ala Ile Leu Ala Glu Ala 
        515                 520                 525             


Ile Ala Ser His Leu Arg Gln Tyr Ser Ala Asn Gly Ala Ala Asp Gly 
    530                 535                 540                 


Met Thr Glu Arg Leu Ile Ser Gly Leu Ala Ser His Asp Trp Asp Trp 
545                 550                 555                 560 


Arg Glu Ser Asn Asp Ser Ala Ala Arg Ser Leu Leu Tyr Ala Leu Asp 
                565                 570                 575     


Glu Leu Ile Asp Leu His Ala Phe Gly Asn Ala Ser Asp Ser Leu Arg 
            580                 585                 590         


Glu Ala Trp Lys Gln Trp Leu Met Ser Trp Thr Asn Glu Ser Gln Gly 
        595                 600                 605             


Ser Thr Gly Gly Asp Thr Ala Leu Leu Leu Val Arg Thr Ile Glu Ile 
    610                 615                 620                 


Cys Ser Gly Arg His Gly Ser Ala Glu Gln Ser Leu Lys Asn Ser Glu 
625                 630                 635                 640 


Asp Tyr Ala Arg Leu Glu Gln Ile Ala Ser Ser Met Cys Ser Lys Leu 
                645                 650                 655     


Ala Thr Lys Ile Leu Ala Gln Asn Gly Gly Ser Met Asp Asn Val Glu 
            660                 665                 670         


Gly Ile Asp Gln Glu Val Asp Val Glu Met Lys Glu Leu Ile Gln Arg 
        675                 680                 685             


Val Tyr Gly Ser Ser Ser Asn Asp Val Ser Ser Val Thr Arg Gln Thr 
    690                 695                 700                 


Phe Leu Asp Val Val Lys Ser Phe Cys Tyr Val Ala His Cys Ser Pro 
705                 710                 715                 720 


Glu Thr Ile Asp Gly His Ile Ser Lys Val Leu Phe Glu Asp Val Asn 
                725                 730                 735     


<210>  5
<211>  757
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  5

Met Lys Arg Glu Gln Tyr Thr Ile Leu Asn Glu Lys Glu Ser Met Ala 
1               5                   10                  15      


Glu Glu Leu Ile Leu Arg Ile Lys Arg Met Phe Ser Glu Ile Glu Asn 
            20                  25                  30          


Thr Gln Thr Ser Ala Ser Ala Tyr Asp Thr Ala Trp Val Ala Met Val 
        35                  40                  45              


Pro Ser Leu Asp Ser Ser Gln Gln Pro Gln Phe Pro Gln Cys Leu Ser 
    50                  55                  60                  


Trp Ile Ile Asp Asn Gln Leu Leu Asp Gly Ser Trp Gly Ile Pro Tyr 
65                  70                  75                  80  


Leu Ile Ile Lys Asp Arg Leu Cys His Thr Leu Ala Cys Val Ile Ala 
                85                  90                  95      


Leu Arg Lys Trp Asn Ala Gly Asn Gln Asn Val Glu Thr Gly Leu Arg 
            100                 105                 110         


Phe Leu Arg Glu Asn Ile Glu Gly Ile Val His Glu Asp Glu Tyr Thr 
        115                 120                 125             


Pro Ile Gly Phe Gln Ile Ile Phe Pro Ala Met Leu Glu Glu Ala Arg 
    130                 135                 140                 


Gly Leu Gly Leu Glu Leu Pro Tyr Asp Leu Thr Pro Ile Lys Leu Met 
145                 150                 155                 160 


Leu Thr His Arg Glu Lys Ile Met Lys Gly Lys Ala Ile Asp His Met 
                165                 170                 175     


His Glu Tyr Asp Ser Ser Leu Ile Tyr Thr Val Glu Gly Ile His Lys 
            180                 185                 190         


Ile Val Asp Trp Asn Lys Val Leu Lys His Gln Asn Lys Asp Gly Ser 
        195                 200                 205             


Leu Phe Asn Ser Pro Ser Ala Thr Ala Cys Ala Leu Met His Thr Arg 
    210                 215                 220                 


Lys Ser Asn Cys Leu Glu Tyr Leu Ser Ser Met Leu Gln Lys Leu Gly 
225                 230                 235                 240 


Asn Gly Val Pro Ser Val Tyr Pro Ile Asn Leu Tyr Ala Arg Ile Ser 
                245                 250                 255     


Met Ile Asp Arg Leu Gln Arg Leu Gly Leu Ala Arg His Phe Arg Asn 
            260                 265                 270         


Glu Ile Ile His Ala Leu Asp Asp Ile Tyr Arg Tyr Trp Met Gln Arg 
        275                 280                 285             


Glu Thr Ser Arg Glu Gly Lys Ser Leu Thr Pro Asp Ile Val Ser Thr 
    290                 295                 300                 


Ser Ile Ala Phe Met Leu Leu Arg Leu His Gly Tyr Asp Val Pro Ala 
305                 310                 315                 320 


Asp Val Phe Cys Cys Tyr Asp Leu His Ser Ile Glu Gln Ser Gly Glu 
                325                 330                 335     


Ala Val Thr Ala Met Leu Ser Leu Tyr Arg Ala Ser Gln Ile Met Phe 
            340                 345                 350         


Pro Gly Glu Thr Ile Leu Glu Glu Ile Lys Thr Val Ser Arg Lys Tyr 
        355                 360                 365             


Leu Asp Lys Arg Lys Glu Asn Gly Gly Ile Tyr Asp His Asn Ile Val 
    370                 375                 380                 


Met Lys Asp Leu Arg Gly Glu Val Glu Tyr Ala Leu Ser Val Pro Trp 
385                 390                 395                 400 


Tyr Ala Ser Leu Glu Arg Ile Glu Asn Arg Arg Tyr Ile Asp Gln Tyr 
                405                 410                 415     


Gly Val Asn Asp Thr Trp Ile Ala Lys Thr Ser Tyr Lys Ile Pro Cys 
            420                 425                 430         


Ile Ser Asn Asp Leu Phe Leu Ala Leu Ala Lys Gln Asp Tyr Asn Ile 
        435                 440                 445             


Cys Gln Ala Ile Gln Gln Lys Glu Leu Arg Glu Leu Glu Arg Trp Phe 
    450                 455                 460                 


Ala Asp Asn Lys Phe Ser His Leu Asn Phe Ala Arg Gln Lys Leu Ile 
465                 470                 475                 480 


Tyr Cys Tyr Phe Ser Ala Ala Ala Thr Leu Phe Ser Pro Glu Leu Ser 
                485                 490                 495     


Ala Ala Arg Val Val Trp Ala Lys Asn Gly Val Ile Thr Thr Val Val 
            500                 505                 510         


Asp Asp Phe Phe Asp Val Gly Gly Ser Ser Glu Glu Ile His Ser Phe 
        515                 520                 525             


Val Glu Ala Val Arg Val Trp Asp Glu Ala Ala Thr Asp Gly Leu Ser 
    530                 535                 540                 


Glu Asn Val Gln Ile Leu Phe Ser Ala Leu Tyr Asn Thr Val Asp Glu 
545                 550                 555                 560 


Ile Val Gln Gln Ala Phe Val Phe Gln Gly Arg Asp Ile Ser Ile His 
                565                 570                 575     


Leu Arg Glu Ile Trp Tyr Arg Leu Val Asn Ser Met Met Thr Glu Ala 
            580                 585                 590         


Gln Trp Ala Arg Thr His Cys Leu Pro Ser Met His Glu Tyr Met Glu 
        595                 600                 605             


Asn Ala Glu Pro Ser Ile Ala Leu Glu Pro Ile Val Leu Ser Ser Leu 
    610                 615                 620                 


Tyr Phe Val Gly Pro Lys Leu Ser Glu Glu Ile Ile Cys His Pro Glu 
625                 630                 635                 640 


Tyr Tyr Asn Leu Met His Leu Leu Asn Ile Cys Gly Arg Leu Leu Asn 
                645                 650                 655     


Asp Ile Gln Gly Cys Lys Arg Glu Ala His Gln Gly Lys Leu Asn Ser 
            660                 665                 670         


Val Thr Leu Tyr Met Glu Glu Asn Ser Gly Thr Thr Met Glu Asp Ala 
        675                 680                 685             


Ile Val Tyr Leu Arg Lys Thr Ile Asp Glu Ser Arg Gln Leu Leu Leu 
    690                 695                 700                 


Lys Glu Val Leu Arg Pro Ser Ile Val Pro Arg Glu Cys Lys Gln Leu 
705                 710                 715                 720 


His Trp Asn Met Met Arg Ile Leu Gln Leu Phe Tyr Leu Lys Asn Asp 
                725                 730                 735     


Gly Phe Thr Ser Pro Thr Glu Met Leu Gly Tyr Val Asn Ala Val Ile 
            740                 745                 750         


Val Asp Pro Ile Leu 
        755         


<210>  6
<211>  499
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  6

Met Asp Thr Leu Thr Leu Ser Leu Gly Phe Leu Ser Leu Phe Leu Phe 
1               5                   10                  15      


Leu Phe Leu Leu Lys Arg Ser Thr His Lys His Ser Lys Leu Ser His 
            20                  25                  30          


Val Pro Val Val Pro Gly Leu Pro Val Ile Gly Asn Leu Leu Gln Leu 
        35                  40                  45              


Lys Glu Lys Lys Pro His Lys Thr Phe Thr Lys Met Ala Gln Lys Tyr 
    50                  55                  60                  


Gly Pro Ile Phe Ser Ile Lys Ala Gly Ser Ser Lys Ile Ile Val Leu 
65                  70                  75                  80  


Asn Thr Ala His Leu Ala Lys Glu Ala Met Val Thr Arg Tyr Ser Ser 
                85                  90                  95      


Ile Ser Lys Arg Lys Leu Ser Thr Ala Leu Thr Ile Leu Thr Ser Asp 
            100                 105                 110         


Lys Cys Met Val Ala Met Ser Asp Tyr Asn Asp Phe His Lys Met Val 
        115                 120                 125             


Lys Lys His Ile Leu Ala Ser Val Leu Gly Ala Asn Ala Gln Lys Arg 
    130                 135                 140                 


Leu Arg Phe His Arg Glu Val Met Met Glu Asn Met Ser Ser Lys Phe 
145                 150                 155                 160 


Asn Glu His Val Lys Thr Leu Ser Asp Ser Ala Val Asp Phe Arg Lys 
                165                 170                 175     


Ile Phe Val Ser Glu Leu Phe Gly Leu Ala Leu Lys Gln Ala Leu Gly 
            180                 185                 190         


Ser Asp Ile Glu Ser Ile Tyr Val Glu Gly Leu Thr Ala Thr Leu Ser 
        195                 200                 205             


Arg Glu Asp Leu Tyr Asn Thr Leu Val Val Asp Phe Met Glu Gly Ala 
    210                 215                 220                 


Ile Glu Val Asp Trp Arg Asp Phe Phe Pro Tyr Leu Lys Trp Ile Pro 
225                 230                 235                 240 


Asn Lys Ser Phe Glu Lys Lys Ile Arg Arg Val Asp Arg Gln Arg Lys 
                245                 250                 255     


Ile Ile Met Lys Ala Leu Ile Asn Glu Gln Lys Lys Arg Leu Thr Ser 
            260                 265                 270         


Gly Lys Glu Leu Asp Cys Tyr Tyr Asp Tyr Leu Val Ser Glu Ala Lys 
        275                 280                 285             


Glu Val Thr Glu Glu Gln Met Ile Met Leu Leu Trp Glu Pro Ile Ile 
    290                 295                 300                 


Glu Thr Ser Asp Thr Thr Leu Val Thr Thr Glu Trp Ala Met Tyr Glu 
305                 310                 315                 320 


Leu Ala Lys Asp Lys Asn Arg Gln Asp Arg Leu Tyr Glu Glu Leu Leu 
                325                 330                 335     


Asn Val Cys Gly His Glu Lys Val Thr Asp Glu Glu Leu Ser Lys Leu 
            340                 345                 350         


Pro Tyr Leu Gly Ala Val Phe His Glu Thr Leu Arg Lys His Ser Pro 
        355                 360                 365             


Val Pro Ile Val Pro Leu Arg Tyr Val Asp Glu Asp Thr Glu Leu Gly 
    370                 375                 380                 


Gly Tyr His Ile Pro Ala Gly Ser Glu Ile Ala Ile Asn Ile Tyr Gly 
385                 390                 395                 400 


Cys Asn Met Asp Ser Asn Leu Trp Glu Asn Pro Asp Gln Trp Ile Pro 
                405                 410                 415     


Glu Arg Phe Leu Asp Glu Lys Tyr Ala Gln Ala Asp Leu Tyr Lys Thr 
            420                 425                 430         


Met Ala Phe Gly Gly Gly Lys Arg Val Cys Ala Gly Ser Leu Gln Ala 
        435                 440                 445             


Met Leu Ile Ala Cys Thr Ala Ile Gly Arg Leu Val Gln Glu Phe Glu 
    450                 455                 460                 


Trp Glu Leu Gly His Gly Glu Glu Glu Asn Val Asp Thr Met Gly Leu 
465                 470                 475                 480 


Thr Thr His Arg Leu His Pro Leu Gln Val Lys Leu Lys Pro Arg Asn 
                485                 490                 495     


Arg Ile Tyr 
            


<210>  7
<211>  711
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  7

Met Ser Ser Ser Ser Ser Ser Ser Thr Ser Met Ile Asp Leu Met Ala 
1               5                   10                  15      


Ala Ile Ile Lys Gly Glu Pro Val Ile Val Ser Asp Pro Ala Asn Ala 
            20                  25                  30          


Ser Ala Tyr Glu Ser Val Ala Ala Glu Leu Ser Ser Met Leu Ile Glu 
        35                  40                  45              


Asn Arg Gln Phe Ala Met Ile Val Thr Thr Ser Ile Ala Val Leu Ile 
    50                  55                  60                  


Gly Cys Ile Val Met Leu Val Trp Arg Arg Ser Gly Ser Gly Asn Ser 
65                  70                  75                  80  


Lys Arg Val Glu Pro Leu Lys Pro Leu Val Ile Lys Pro Arg Glu Glu 
                85                  90                  95      


Glu Ile Asp Asp Gly Arg Lys Lys Val Thr Ile Phe Phe Gly Thr Gln 
            100                 105                 110         


Thr Gly Thr Ala Glu Gly Phe Ala Lys Ala Leu Gly Glu Glu Ala Lys 
        115                 120                 125             


Ala Arg Tyr Glu Lys Thr Arg Phe Lys Ile Val Asp Leu Asp Asp Tyr 
    130                 135                 140                 


Ala Ala Asp Asp Asp Glu Tyr Glu Glu Lys Leu Lys Lys Glu Asp Val 
145                 150                 155                 160 


Ala Phe Phe Phe Leu Ala Thr Tyr Gly Asp Gly Glu Pro Thr Asp Asn 
                165                 170                 175     


Ala Ala Arg Phe Tyr Lys Trp Phe Thr Glu Gly Asn Asp Arg Gly Glu 
            180                 185                 190         


Trp Leu Lys Asn Leu Lys Tyr Gly Val Phe Gly Leu Gly Asn Arg Gln 
        195                 200                 205             


Tyr Glu His Phe Asn Lys Val Ala Lys Val Val Asp Asp Ile Leu Val 
    210                 215                 220                 


Glu Gln Gly Ala Gln Arg Leu Val Gln Val Gly Leu Gly Asp Asp Asp 
225                 230                 235                 240 


Gln Cys Ile Glu Asp Asp Phe Thr Ala Trp Arg Glu Ala Leu Trp Pro 
                245                 250                 255     


Glu Leu Asp Thr Ile Leu Arg Glu Glu Gly Asp Thr Ala Val Ala Thr 
            260                 265                 270         


Pro Tyr Thr Ala Ala Val Leu Glu Tyr Arg Val Ser Ile His Asp Ser 
        275                 280                 285             


Glu Asp Ala Lys Phe Asn Asp Ile Asn Met Ala Asn Gly Asn Gly Tyr 
    290                 295                 300                 


Thr Val Phe Asp Ala Gln His Pro Tyr Lys Ala Asn Val Ala Val Lys 
305                 310                 315                 320 


Arg Glu Leu His Thr Pro Glu Ser Asp Arg Ser Cys Ile His Leu Glu 
                325                 330                 335     


Phe Asp Ile Ala Gly Ser Gly Leu Thr Tyr Glu Thr Gly Asp His Val 
            340                 345                 350         


Gly Val Leu Cys Asp Asn Leu Ser Glu Thr Val Asp Glu Ala Leu Arg 
        355                 360                 365             


Leu Leu Asp Met Ser Pro Asp Thr Tyr Phe Ser Leu His Ala Glu Lys 
    370                 375                 380                 


Glu Asp Gly Thr Pro Ile Ser Ser Ser Leu Pro Pro Pro Phe Pro Pro 
385                 390                 395                 400 


Cys Asn Leu Arg Thr Ala Leu Thr Arg Tyr Ala Cys Leu Leu Ser Ser 
                405                 410                 415     


Pro Lys Lys Ser Ala Leu Val Ala Leu Ala Ala His Ala Ser Asp Pro 
            420                 425                 430         


Thr Glu Ala Glu Arg Leu Lys His Leu Ala Ser Pro Ala Gly Lys Asp 
        435                 440                 445             


Glu Tyr Ser Lys Trp Val Val Glu Ser Gln Arg Ser Leu Leu Glu Val 
    450                 455                 460                 


Met Ala Glu Phe Pro Ser Ala Lys Pro Pro Leu Gly Val Phe Phe Ala 
465                 470                 475                 480 


Gly Val Ala Pro Arg Leu Gln Pro Arg Phe Tyr Ser Ile Ser Ser Ser 
                485                 490                 495     


Pro Lys Ile Ala Glu Thr Arg Ile His Val Thr Cys Ala Leu Val Tyr 
            500                 505                 510         


Glu Lys Met Pro Thr Gly Arg Ile His Lys Gly Val Cys Ser Thr Trp 
        515                 520                 525             


Met Lys Asn Ala Val Pro Tyr Glu Lys Ser Glu Asn Cys Ser Ser Ala 
    530                 535                 540                 


Pro Ile Phe Val Arg Gln Ser Asn Phe Lys Leu Pro Ser Asp Ser Lys 
545                 550                 555                 560 


Val Pro Ile Ile Met Ile Gly Pro Gly Thr Gly Leu Ala Pro Phe Arg 
                565                 570                 575     


Gly Phe Leu Gln Glu Arg Leu Ala Leu Val Glu Ser Gly Val Glu Leu 
            580                 585                 590         


Gly Pro Ser Val Leu Phe Phe Gly Cys Arg Asn Arg Arg Met Asp Phe 
        595                 600                 605             


Ile Tyr Glu Glu Glu Leu Gln Arg Phe Val Glu Ser Gly Ala Leu Ala 
    610                 615                 620                 


Glu Leu Ser Val Ala Phe Ser Arg Glu Gly Pro Thr Lys Glu Tyr Val 
625                 630                 635                 640 


Gln His Lys Met Met Asp Lys Ala Ser Asp Ile Trp Asn Met Ile Ser 
                645                 650                 655     


Gln Gly Ala Tyr Leu Tyr Val Cys Gly Asp Ala Lys Gly Met Ala Arg 
            660                 665                 670         


Asp Val His Arg Ser Leu His Thr Ile Ala Gln Glu Gln Gly Ser Met 
        675                 680                 685             


Asp Ser Thr Lys Ala Glu Gly Phe Val Lys Asn Leu Gln Thr Ser Gly 
    690                 695                 700                 


Arg Tyr Leu Arg Asp Val Trp 
705                 710     


<210>  8
<211>  481
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  8

Met Asp Ala Met Ala Thr Thr Glu Lys Lys Pro His Val Ile Phe Ile 
1               5                   10                  15      


Pro Phe Pro Ala Gln Ser His Ile Lys Ala Met Leu Lys Leu Ala Gln 
            20                  25                  30          


Leu Leu His His Lys Gly Leu Gln Ile Thr Phe Val Asn Thr Asp Phe 
        35                  40                  45              


Ile His Asn Gln Phe Leu Glu Ser Ser Gly Pro His Cys Leu Asp Gly 
    50                  55                  60                  


Ala Pro Gly Phe Arg Phe Glu Thr Ile Pro Asp Gly Val Ser His Ser 
65                  70                  75                  80  


Pro Glu Ala Ser Ile Pro Ile Arg Glu Ser Leu Leu Arg Ser Ile Glu 
                85                  90                  95      


Thr Asn Phe Leu Asp Arg Phe Ile Asp Leu Val Thr Lys Leu Pro Asp 
            100                 105                 110         


Pro Pro Thr Cys Ile Ile Ser Asp Gly Phe Leu Ser Val Phe Thr Ile 
        115                 120                 125             


Asp Ala Ala Lys Lys Leu Gly Ile Pro Val Met Met Tyr Trp Thr Leu 
    130                 135                 140                 


Ala Ala Cys Gly Phe Met Gly Phe Tyr His Ile His Ser Leu Ile Glu 
145                 150                 155                 160 


Lys Gly Phe Ala Pro Leu Lys Asp Ala Ser Tyr Leu Thr Asn Gly Tyr 
                165                 170                 175     


Leu Asp Thr Val Ile Asp Trp Val Pro Gly Met Glu Gly Ile Arg Leu 
            180                 185                 190         


Lys Asp Phe Pro Leu Asp Trp Ser Thr Asp Leu Asn Asp Lys Val Leu 
        195                 200                 205             


Met Phe Thr Thr Glu Ala Pro Gln Arg Ser His Lys Val Ser His His 
    210                 215                 220                 


Ile Phe His Thr Phe Asp Glu Leu Glu Pro Ser Ile Ile Lys Thr Leu 
225                 230                 235                 240 


Ser Leu Arg Tyr Asn His Ile Tyr Thr Ile Gly Pro Leu Gln Leu Leu 
                245                 250                 255     


Leu Asp Gln Ile Pro Glu Glu Lys Lys Gln Thr Gly Ile Thr Ser Leu 
            260                 265                 270         


His Gly Tyr Ser Leu Val Lys Glu Glu Pro Glu Cys Phe Gln Trp Leu 
        275                 280                 285             


Gln Ser Lys Glu Pro Asn Ser Val Val Tyr Val Asn Phe Gly Ser Thr 
    290                 295                 300                 


Thr Val Met Ser Leu Glu Asp Met Thr Glu Phe Gly Trp Gly Leu Ala 
305                 310                 315                 320 


Asn Ser Asn His Tyr Phe Leu Trp Ile Ile Arg Ser Asn Leu Val Ile 
                325                 330                 335     


Gly Glu Asn Ala Val Leu Pro Pro Glu Leu Glu Glu His Ile Lys Lys 
            340                 345                 350         


Arg Gly Phe Ile Ala Ser Trp Cys Ser Gln Glu Lys Val Leu Lys His 
        355                 360                 365             


Pro Ser Val Gly Gly Phe Leu Thr His Cys Gly Trp Gly Ser Thr Ile 
    370                 375                 380                 


Glu Ser Leu Ser Ala Gly Val Pro Met Ile Cys Trp Pro Tyr Ser Trp 
385                 390                 395                 400 


Asp Gln Leu Thr Asn Cys Arg Tyr Ile Cys Lys Glu Trp Glu Val Gly 
                405                 410                 415     


Leu Glu Met Gly Thr Lys Val Lys Arg Asp Glu Val Lys Arg Leu Val 
            420                 425                 430         


Gln Glu Leu Met Gly Glu Gly Gly His Lys Met Arg Asn Lys Ala Lys 
        435                 440                 445             


Asp Trp Lys Glu Lys Ala Arg Ile Ala Ile Ala Pro Asn Gly Ser Ser 
    450                 455                 460                 


Ser Leu Asn Ile Asp Lys Met Val Lys Glu Ile Thr Val Leu Ala Arg 
465                 470                 475                 480 


Asn 
    


<210>  9
<211>  460
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  9

Met Ala Glu Gln Gln Lys Ile Lys Lys Ser Pro His Val Leu Leu Ile 
1               5                   10                  15      


Pro Phe Pro Leu Gln Gly His Ile Asn Pro Phe Ile Gln Phe Gly Lys 
            20                  25                  30          


Arg Leu Ile Ser Lys Gly Val Lys Thr Thr Leu Val Thr Thr Ile His 
        35                  40                  45              


Thr Leu Asn Ser Thr Leu Asn His Ser Asn Thr Thr Thr Thr Ser Ile 
    50                  55                  60                  


Glu Ile Gln Ala Ile Ser Asp Gly Cys Asp Glu Gly Gly Phe Met Ser 
65                  70                  75                  80  


Ala Gly Glu Ser Tyr Leu Glu Thr Phe Lys Gln Val Gly Ser Lys Ser 
                85                  90                  95      


Leu Ala Asp Leu Ile Lys Lys Leu Gln Ser Glu Gly Thr Thr Ile Asp 
            100                 105                 110         


Ala Ile Ile Tyr Asp Ser Met Thr Glu Trp Val Leu Asp Val Ala Ile 
        115                 120                 125             


Glu Phe Gly Ile Asp Gly Gly Ser Phe Phe Thr Gln Ala Cys Val Val 
    130                 135                 140                 


Asn Ser Leu Tyr Tyr His Val His Lys Gly Leu Ile Ser Leu Pro Leu 
145                 150                 155                 160 


Gly Glu Thr Val Ser Val Pro Gly Phe Pro Val Leu Gln Arg Trp Glu 
                165                 170                 175     


Thr Pro Leu Ile Leu Gln Asn His Glu Gln Ile Gln Ser Pro Trp Ser 
            180                 185                 190         


Gln Met Leu Phe Gly Gln Phe Ala Asn Ile Asp Gln Ala Arg Trp Val 
        195                 200                 205             


Phe Thr Asn Ser Phe Tyr Lys Leu Glu Glu Glu Val Ile Glu Trp Thr 
    210                 215                 220                 


Arg Lys Ile Trp Asn Leu Lys Val Ile Gly Pro Thr Leu Pro Ser Met 
225                 230                 235                 240 


Tyr Leu Asp Lys Arg Leu Asp Asp Asp Lys Asp Asn Gly Phe Asn Leu 
                245                 250                 255     


Tyr Lys Ala Asn His His Glu Cys Met Asn Trp Leu Asp Asp Lys Pro 
            260                 265                 270         


Lys Glu Ser Val Val Tyr Val Ala Phe Gly Ser Leu Val Lys His Gly 
        275                 280                 285             


Pro Glu Gln Val Glu Glu Ile Thr Arg Ala Leu Ile Asp Ser Asp Val 
    290                 295                 300                 


Asn Phe Leu Trp Val Ile Lys His Lys Glu Glu Gly Lys Leu Pro Glu 
305                 310                 315                 320 


Asn Leu Ser Glu Val Ile Lys Thr Gly Lys Gly Leu Ile Val Ala Trp 
                325                 330                 335     


Cys Lys Gln Leu Asp Val Leu Ala His Glu Ser Val Gly Cys Phe Val 
            340                 345                 350         


Thr His Cys Gly Phe Asn Ser Thr Leu Glu Ala Ile Ser Leu Gly Val 
        355                 360                 365             


Pro Val Val Ala Met Pro Gln Phe Ser Asp Gln Thr Thr Asn Ala Lys 
    370                 375                 380                 


Leu Leu Asp Glu Ile Leu Gly Val Gly Val Arg Val Lys Ala Asp Glu 
385                 390                 395                 400 


Asn Gly Ile Val Arg Arg Gly Asn Leu Ala Ser Cys Ile Lys Met Ile 
                405                 410                 415     


Met Glu Glu Glu Arg Gly Val Ile Ile Arg Lys Asn Ala Val Lys Trp 
            420                 425                 430         


Lys Asp Leu Ala Lys Val Ala Val His Glu Gly Gly Ser Ser Asp Asn 
        435                 440                 445             


Asp Ile Val Glu Phe Val Ser Glu Leu Ile Lys Ala 
    450                 455                 460 


<210>  10
<211>  485
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  10

Met Tyr Asn Val Thr Tyr His Gln Asn Ser Lys Ala Met Ala Thr Ser 
1               5                   10                  15      


Asp Ser Ile Val Asp Asp Arg Lys Gln Leu His Val Ala Thr Phe Pro 
            20                  25                  30          


Trp Leu Ala Phe Gly His Ile Leu Pro Tyr Leu Gln Leu Ser Lys Leu 
        35                  40                  45              


Ile Ala Glu Lys Gly His Lys Val Ser Phe Leu Ser Thr Thr Arg Asn 
    50                  55                  60                  


Ile Gln Arg Leu Ser Ser His Ile Ser Pro Leu Ile Asn Val Val Gln 
65                  70                  75                  80  


Leu Thr Leu Pro Arg Val Gln Glu Leu Pro Glu Asp Ala Glu Ala Thr 
                85                  90                  95      


Thr Asp Val His Pro Glu Asp Ile Pro Tyr Leu Lys Lys Ala Ser Asp 
            100                 105                 110         


Gly Leu Gln Pro Glu Val Thr Arg Phe Leu Glu Gln His Ser Pro Asp 
        115                 120                 125             


Trp Ile Ile Tyr Asp Tyr Thr His Tyr Trp Leu Pro Ser Ile Ala Ala 
    130                 135                 140                 


Ser Leu Gly Ile Ser Arg Ala His Phe Ser Val Thr Thr Pro Trp Ala 
145                 150                 155                 160 


Ile Ala Tyr Met Gly Pro Ser Ala Asp Ala Met Ile Asn Gly Ser Asp 
                165                 170                 175     


Gly Arg Thr Thr Val Glu Asp Leu Thr Thr Pro Pro Lys Trp Phe Pro 
            180                 185                 190         


Phe Pro Thr Lys Val Cys Trp Arg Lys His Asp Leu Ala Arg Leu Val 
        195                 200                 205             


Pro Tyr Lys Ala Pro Gly Ile Ser Asp Gly Tyr Arg Met Gly Leu Val 
    210                 215                 220                 


Leu Lys Gly Ser Asp Cys Leu Leu Ser Lys Cys Tyr His Glu Phe Gly 
225                 230                 235                 240 


Thr Gln Trp Leu Pro Leu Leu Glu Thr Leu His Gln Val Pro Val Val 
                245                 250                 255     


Pro Val Gly Leu Leu Pro Pro Glu Ile Pro Gly Asp Glu Lys Asp Glu 
            260                 265                 270         


Thr Trp Val Ser Ile Lys Lys Trp Leu Asp Gly Lys Gln Lys Gly Ser 
        275                 280                 285             


Val Val Tyr Val Ala Leu Gly Ser Glu Val Leu Val Ser Gln Thr Glu 
    290                 295                 300                 


Val Val Glu Leu Ala Leu Gly Leu Glu Leu Ser Gly Leu Pro Phe Val 
305                 310                 315                 320 


Trp Ala Tyr Arg Lys Pro Lys Gly Pro Ala Lys Ser Asp Ser Val Glu 
                325                 330                 335     


Leu Pro Asp Gly Phe Val Glu Arg Thr Arg Asp Arg Gly Leu Val Trp 
            340                 345                 350         


Thr Ser Trp Ala Pro Gln Leu Arg Ile Leu Ser His Glu Ser Val Cys 
        355                 360                 365             


Gly Phe Leu Thr His Cys Gly Ser Gly Ser Ile Val Glu Gly Leu Met 
    370                 375                 380                 


Phe Gly His Pro Leu Ile Met Leu Pro Ile Phe Gly Asp Gln Pro Leu 
385                 390                 395                 400 


Asn Ala Arg Leu Leu Glu Asp Lys Gln Val Gly Ile Glu Ile Pro Arg 
                405                 410                 415     


Asn Glu Glu Asp Gly Cys Leu Thr Lys Glu Ser Val Ala Arg Ser Leu 
            420                 425                 430         


Arg Ser Val Val Val Glu Lys Glu Gly Glu Ile Tyr Lys Ala Asn Ala 
        435                 440                 445             


Arg Glu Leu Ser Lys Ile Tyr Asn Asp Thr Lys Val Glu Lys Glu Tyr 
    450                 455                 460                 


Val Ser Gln Phe Val Asp Tyr Leu Glu Lys Asn Ala Arg Ala Val Ala 
465                 470                 475                 480 


Ile Asp His Glu Ser 
                485 


<210>  11
<211>  458
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  11

Met Glu Asn Lys Thr Glu Thr Thr Val Arg Arg Arg Arg Arg Ile Ile 
1               5                   10                  15      


Leu Phe Pro Val Pro Phe Gln Gly His Ile Asn Pro Ile Leu Gln Leu 
            20                  25                  30          


Ala Asn Val Leu Tyr Ser Lys Gly Phe Ser Ile Thr Ile Phe His Thr 
        35                  40                  45              


Asn Phe Asn Lys Pro Lys Thr Ser Asn Tyr Pro His Phe Thr Phe Arg 
    50                  55                  60                  


Phe Ile Leu Asp Asn Asp Pro Gln Asp Glu Arg Ile Ser Asn Leu Pro 
65                  70                  75                  80  


Thr His Gly Pro Leu Ala Gly Met Arg Ile Pro Ile Ile Asn Glu His 
                85                  90                  95      


Gly Ala Asp Glu Leu Arg Arg Glu Leu Glu Leu Leu Met Leu Ala Ser 
            100                 105                 110         


Glu Glu Asp Glu Glu Val Ser Cys Leu Ile Thr Asp Ala Leu Trp Tyr 
        115                 120                 125             


Phe Ala Gln Ser Val Ala Asp Ser Leu Asn Leu Arg Arg Leu Val Leu 
    130                 135                 140                 


Met Thr Ser Ser Leu Phe Asn Phe His Ala His Val Ser Leu Pro Gln 
145                 150                 155                 160 


Phe Asp Glu Leu Gly Tyr Leu Asp Pro Asp Asp Lys Thr Arg Leu Glu 
                165                 170                 175     


Glu Gln Ala Ser Gly Phe Pro Met Leu Lys Val Lys Asp Ile Lys Ser 
            180                 185                 190         


Ala Tyr Ser Asn Trp Gln Ile Leu Lys Glu Ile Leu Gly Lys Met Ile 
        195                 200                 205             


Lys Gln Thr Lys Ala Ser Ser Gly Val Ile Trp Asn Ser Phe Lys Glu 
    210                 215                 220                 


Leu Glu Glu Ser Glu Leu Glu Thr Val Ile Arg Glu Ile Pro Ala Pro 
225                 230                 235                 240 


Ser Phe Leu Ile Pro Leu Pro Lys His Leu Thr Ala Ser Ser Ser Ser 
                245                 250                 255     


Leu Leu Asp His Asp Arg Thr Val Phe Gln Trp Leu Asp Gln Gln Pro 
            260                 265                 270         


Pro Ser Ser Val Leu Tyr Val Ser Phe Gly Ser Thr Ser Glu Val Asp 
        275                 280                 285             


Glu Lys Asp Phe Leu Glu Ile Ala Arg Gly Leu Val Asp Ser Lys Gln 
    290                 295                 300                 


Ser Phe Leu Trp Val Val Arg Pro Gly Phe Val Lys Gly Ser Thr Trp 
305                 310                 315                 320 


Val Glu Pro Leu Pro Asp Gly Phe Leu Gly Glu Arg Gly Arg Ile Val 
                325                 330                 335     


Lys Trp Val Pro Gln Gln Glu Val Leu Ala His Gly Ala Ile Gly Ala 
            340                 345                 350         


Phe Trp Thr His Ser Gly Trp Asn Ser Thr Leu Glu Ser Val Cys Glu 
        355                 360                 365             


Gly Val Pro Met Ile Phe Ser Asp Phe Gly Leu Asp Gln Pro Leu Asn 
    370                 375                 380                 


Ala Arg Tyr Met Ser Asp Val Leu Lys Val Gly Val Tyr Leu Glu Asn 
385                 390                 395                 400 


Gly Trp Glu Arg Gly Glu Ile Ala Asn Ala Ile Arg Arg Val Met Val 
                405                 410                 415     


Asp Glu Glu Gly Glu Tyr Ile Arg Gln Asn Ala Arg Val Leu Lys Gln 
            420                 425                 430         


Lys Ala Asp Val Ser Leu Met Lys Gly Gly Ser Ser Tyr Glu Ser Leu 
        435                 440                 445             


Glu Ser Leu Val Ser Tyr Ile Ser Ser Leu 
    450                 455             


<210>  12
<211>  436
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  12

Met Asp Ala Ser Asp Ser Ser Pro Leu His Ile Val Ile Phe Pro Trp 
1               5                   10                  15      


Leu Ala Phe Gly His Met Leu Ala Ser Leu Glu Leu Ala Glu Arg Leu 
            20                  25                  30          


Ala Ala Arg Gly His Arg Val Ser Phe Val Ser Thr Pro Arg Asn Ile 
        35                  40                  45              


Ser Arg Leu Arg Pro Val Pro Pro Ala Leu Ala Pro Leu Ile Asp Phe 
    50                  55                  60                  


Val Ala Leu Pro Leu Pro Arg Val Asp Gly Leu Pro Asp Gly Ala Glu 
65                  70                  75                  80  


Ala Thr Ser Asp Ile Pro Pro Gly Lys Thr Glu Leu His Leu Lys Ala 
                85                  90                  95      


Leu Asp Gly Leu Ala Ala Pro Phe Ala Ala Phe Leu Asp Ala Ala Cys 
            100                 105                 110         


Ala Asp Gly Ser Thr Asn Lys Val Asp Trp Leu Phe Leu Asp Asn Phe 
        115                 120                 125             


Gln Tyr Trp Ala Ala Ala Ala Ala Ala Asp His Lys Ile Pro Cys Ala 
    130                 135                 140                 


Leu Asn Leu Thr Phe Ala Ala Ser Thr Ser Ala Glu Tyr Gly Val Pro 
145                 150                 155                 160 


Arg Val Glu Pro Pro Val Asp Gly Ser Thr Ala Ser Ile Leu Gln Arg 
                165                 170                 175     


Phe Val Leu Thr Leu Glu Lys Cys Gln Phe Val Ile Gln Arg Ala Cys 
            180                 185                 190         


Phe Glu Leu Glu Pro Glu Pro Leu Pro Leu Leu Ser Asp Ile Phe Gly 
        195                 200                 205             


Lys Pro Val Ile Pro Tyr Gly Leu Val Pro Pro Cys Pro Pro Ala Glu 
    210                 215                 220                 


Gly His Lys Arg Glu His Gly Asn Ala Ala Leu Ser Trp Leu Asp Lys 
225                 230                 235                 240 


Gln Gln Pro Glu Ser Val Leu Phe Ile Ala Leu Gly Ser Glu Pro Pro 
                245                 250                 255     


Val Thr Val Glu Gln Leu His Glu Ile Ala Leu Gly Leu Glu Leu Ala 
            260                 265                 270         


Gly Thr Thr Phe Leu Trp Ala Leu Lys Lys Pro Asn Gly Leu Leu Leu 
        275                 280                 285             


Glu Ala Asp Gly Asp Ile Leu Pro Pro Gly Phe Glu Glu Arg Thr Arg 
    290                 295                 300                 


Asp Arg Gly Leu Val Ala Met Gly Trp Val Pro Gln Pro Ile Ile Leu 
305                 310                 315                 320 


Ala His Ser Ser Val Gly Ala Phe Leu Thr His Gly Gly Trp Ala Ser 
                325                 330                 335     


Thr Ile Glu Gly Val Met Ser Gly His Pro Met Leu Phe Leu Thr Phe 
            340                 345                 350         


Leu Asp Glu Gln Arg Ile Asn Ala Gln Leu Ile Glu Arg Lys Lys Ala 
        355                 360                 365             


Gly Leu Arg Val Pro Arg Arg Glu Lys Asp Gly Ser Tyr Asp Arg Gln 
    370                 375                 380                 


Gly Ile Ala Gly Ala Ile Arg Ala Val Met Cys Glu Glu Glu Ser Lys 
385                 390                 395                 400 


Ser Val Phe Ala Ala Asn Ala Lys Lys Met Gln Glu Ile Val Ser Asp 
                405                 410                 415     


Arg Asn Cys Gln Glu Lys Tyr Ile Asp Glu Leu Ile Gln Arg Leu Gly 
            420                 425                 430         


Ser Phe Glu Lys 
        435     


<210>  13
<211>  523
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  13

Met Glu Val Thr Val Ala Ser Ser Val Ala Leu Ser Leu Val Phe Ile 
1               5                   10                  15      


Ser Ile Val Val Arg Trp Ala Trp Ser Val Val Asn Trp Val Trp Phe 
            20                  25                  30          


Lys Pro Lys Lys Leu Glu Arg Phe Leu Arg Glu Gln Gly Leu Lys Gly 
        35                  40                  45              


Asn Ser Tyr Arg Phe Leu Tyr Gly Asp Met Lys Glu Asn Ser Ile Leu 
    50                  55                  60                  


Leu Lys Gln Ala Arg Ser Lys Pro Met Asn Leu Ser Thr Ser His Asp 
65                  70                  75                  80  


Ile Ala Pro Gln Val Thr Pro Phe Val Asp Gln Thr Val Lys Ala Tyr 
                85                  90                  95      


Gly Lys Asn Ser Phe Asn Trp Val Gly Pro Ile Pro Arg Val Asn Ile 
            100                 105                 110         


Met Asn Pro Glu Asp Leu Lys Asp Val Leu Thr Lys Asn Val Asp Phe 
        115                 120                 125             


Val Lys Pro Ile Ser Asn Pro Leu Ile Lys Leu Leu Ala Thr Gly Ile 
    130                 135                 140                 


Ala Ile Tyr Glu Gly Glu Lys Trp Thr Lys His Arg Arg Ile Ile Asn 
145                 150                 155                 160 


Pro Thr Phe His Ser Glu Arg Leu Lys Arg Met Leu Pro Ser Phe His 
                165                 170                 175     


Gln Ser Cys Asn Glu Met Val Lys Glu Trp Glu Ser Leu Val Ser Lys 
            180                 185                 190         


Glu Gly Ser Ser Cys Glu Leu Asp Val Trp Pro Phe Leu Glu Asn Met 
        195                 200                 205             


Ser Ala Asp Val Ile Ser Arg Thr Ala Phe Gly Thr Ser Tyr Lys Lys 
    210                 215                 220                 


Gly Gln Lys Ile Phe Glu Leu Leu Arg Glu Gln Val Ile Tyr Val Thr 
225                 230                 235                 240 


Lys Gly Phe Gln Ser Phe Tyr Ile Pro Gly Trp Arg Phe Leu Pro Thr 
                245                 250                 255     


Lys Met Asn Lys Arg Met Asn Glu Ile Asn Glu Glu Ile Lys Gly Leu 
            260                 265                 270         


Ile Arg Gly Ile Ile Ile Asp Arg Glu Gln Ile Ile Lys Ala Gly Glu 
        275                 280                 285             


Glu Thr Asn Asp Asp Leu Leu Gly Ala Leu Met Glu Ser Asn Leu Lys 
    290                 295                 300                 


Asp Ile Arg Glu His Gly Lys Asn Asn Lys Asn Val Gly Met Ser Ile 
305                 310                 315                 320 


Glu Asp Val Ile Gln Glu Cys Lys Leu Phe Tyr Phe Ala Gly Gln Glu 
                325                 330                 335     


Thr Thr Ser Val Leu Leu Ala Trp Thr Met Val Leu Leu Gly Gln Asn 
            340                 345                 350         


Gln Asn Trp Gln Asp Arg Ala Arg Gln Glu Val Leu Gln Val Phe Gly 
        355                 360                 365             


Ser Ser Lys Pro Asp Phe Asp Gly Leu Ala His Leu Lys Val Val Thr 
    370                 375                 380                 


Met Ile Leu Leu Glu Val Leu Arg Leu Tyr Pro Pro Val Ile Glu Leu 
385                 390                 395                 400 


Ile Arg Thr Ile His Lys Lys Thr Gln Leu Gly Lys Leu Ser Leu Pro 
                405                 410                 415     


Glu Gly Val Glu Val Arg Leu Pro Thr Leu Leu Ile His His Asp Lys 
            420                 425                 430         


Glu Leu Trp Gly Asp Asp Ala Asn Gln Phe Asn Pro Glu Arg Phe Ser 
        435                 440                 445             


Glu Gly Val Ser Lys Ala Thr Lys Asn Arg Leu Ser Phe Phe Pro Phe 
    450                 455                 460                 


Gly Ala Gly Pro Arg Ile Cys Ile Gly Gln Asn Phe Ser Met Met Glu 
465                 470                 475                 480 


Ala Lys Leu Ala Leu Ala Leu Ile Leu Gln His Phe Thr Phe Glu Leu 
                485                 490                 495     


Ser Pro Ser His Ala His Ala Pro Ser His Arg Ile Thr Leu Gln Pro 
            500                 505                 510         


Gln Tyr Gly Val Arg Ile Ile Leu His Arg Arg 
        515                 520             


<210>  14
<211>  525
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  14

Met Glu Ser Leu Val Val His Thr Val Asn Ala Ile Trp Cys Ile Val 
1               5                   10                  15      


Ile Val Gly Ile Phe Ser Val Gly Tyr His Val Tyr Gly Arg Ala Val 
            20                  25                  30          


Val Glu Gln Trp Arg Met Arg Arg Ser Leu Lys Leu Gln Gly Val Lys 
        35                  40                  45              


Gly Pro Pro Pro Ser Ile Phe Asn Gly Asn Val Ser Glu Met Gln Arg 
    50                  55                  60                  


Ile Gln Ser Glu Ala Lys His Cys Ser Gly Asp Asn Ile Ile Ser His 
65                  70                  75                  80  


Asp Tyr Ser Ser Ser Leu Phe Pro His Phe Asp His Trp Arg Lys Gln 
                85                  90                  95      


Tyr Gly Arg Ile Tyr Thr Tyr Ser Thr Gly Leu Lys Gln His Leu Tyr 
            100                 105                 110         


Ile Asn His Pro Glu Met Val Lys Glu Leu Ser Gln Thr Asn Thr Leu 
        115                 120                 125             


Asn Leu Gly Arg Ile Thr His Ile Thr Lys Arg Leu Asn Pro Ile Leu 
    130                 135                 140                 


Gly Asn Gly Ile Ile Thr Ser Asn Gly Pro His Trp Ala His Gln Arg 
145                 150                 155                 160 


Arg Ile Ile Ala Tyr Glu Phe Thr His Asp Lys Ile Lys Gly Met Val 
                165                 170                 175     


Gly Leu Met Val Glu Ser Ala Met Pro Met Leu Asn Lys Trp Glu Glu 
            180                 185                 190         


Met Val Lys Arg Gly Gly Glu Met Gly Cys Asp Ile Arg Val Asp Glu 
        195                 200                 205             


Asp Leu Lys Asp Val Ser Ala Asp Val Ile Ala Lys Ala Cys Phe Gly 
    210                 215                 220                 


Ser Ser Phe Ser Lys Gly Lys Ala Ile Phe Ser Met Ile Arg Asp Leu 
225                 230                 235                 240 


Leu Thr Ala Ile Thr Lys Arg Ser Val Leu Phe Arg Phe Asn Gly Phe 
                245                 250                 255     


Thr Asp Met Val Phe Gly Ser Lys Lys His Gly Asp Val Asp Ile Asp 
            260                 265                 270         


Ala Leu Glu Met Glu Leu Glu Ser Ser Ile Trp Glu Thr Val Lys Glu 
        275                 280                 285             


Arg Glu Ile Glu Cys Lys Asp Thr His Lys Lys Asp Leu Met Gln Leu 
    290                 295                 300                 


Ile Leu Glu Gly Ala Met Arg Ser Cys Asp Gly Asn Leu Trp Asp Lys 
305                 310                 315                 320 


Ser Ala Tyr Arg Arg Phe Val Val Asp Asn Cys Lys Ser Ile Tyr Phe 
                325                 330                 335     


Ala Gly His Asp Ser Thr Ala Val Ser Val Ser Trp Cys Leu Met Leu 
            340                 345                 350         


Leu Ala Leu Asn Pro Ser Trp Gln Val Lys Ile Arg Asp Glu Ile Leu 
        355                 360                 365             


Ser Ser Cys Lys Asn Gly Ile Pro Asp Ala Glu Ser Ile Pro Asn Leu 
    370                 375                 380                 


Lys Thr Val Thr Met Val Ile Gln Glu Thr Met Arg Leu Tyr Pro Pro 
385                 390                 395                 400 


Ala Pro Ile Val Gly Arg Glu Ala Ser Lys Asp Ile Arg Leu Gly Asp 
                405                 410                 415     


Leu Val Val Pro Lys Gly Val Cys Ile Trp Thr Leu Ile Pro Ala Leu 
            420                 425                 430         


His Arg Asp Pro Glu Ile Trp Gly Pro Asp Ala Asn Asp Phe Lys Pro 
        435                 440                 445             


Glu Arg Phe Ser Glu Gly Ile Ser Lys Ala Cys Lys Tyr Pro Gln Ser 
    450                 455                 460                 


Tyr Ile Pro Phe Gly Leu Gly Pro Arg Thr Cys Val Gly Lys Asn Phe 
465                 470                 475                 480 


Gly Met Met Glu Val Lys Val Leu Val Ser Leu Ile Val Ser Lys Phe 
                485                 490                 495     


Ser Phe Thr Leu Ser Pro Thr Tyr Gln His Ser Pro Ser His Lys Leu 
            500                 505                 510         


Leu Val Glu Pro Gln His Gly Val Val Ile Arg Val Val 
        515                 520                 525 


<210>  15
<211>  500
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  15

Met Glu Ala Ser Tyr Leu Tyr Ile Ser Ile Leu Leu Leu Leu Ala Ser 
1               5                   10                  15      


Tyr Leu Phe Thr Thr Gln Leu Arg Arg Lys Ser Ala Asn Leu Pro Pro 
            20                  25                  30          


Thr Val Phe Pro Ser Ile Pro Ile Ile Gly His Leu Tyr Leu Leu Lys 
        35                  40                  45              


Lys Pro Leu Tyr Arg Thr Leu Ala Lys Ile Ala Ala Lys Tyr Gly Pro 
    50                  55                  60                  


Ile Leu Gln Leu Gln Leu Gly Tyr Arg Arg Val Leu Val Ile Ser Ser 
65                  70                  75                  80  


Pro Ser Ala Ala Glu Glu Cys Phe Thr Asn Asn Asp Val Ile Phe Ala 
                85                  90                  95      


Asn Arg Pro Lys Thr Leu Phe Gly Lys Ile Val Gly Gly Thr Ser Leu 
            100                 105                 110         


Gly Ser Leu Ser Tyr Gly Asp Gln Trp Arg Asn Leu Arg Arg Val Ala 
        115                 120                 125             


Ser Ile Glu Ile Leu Ser Val His Arg Leu Asn Glu Phe His Asp Ile 
    130                 135                 140                 


Arg Val Asp Glu Asn Arg Leu Leu Ile Arg Lys Leu Arg Ser Ser Ser 
145                 150                 155                 160 


Ser Pro Val Thr Leu Ile Thr Val Phe Tyr Ala Leu Thr Leu Asn Val 
                165                 170                 175     


Ile Met Arg Met Ile Ser Gly Lys Arg Tyr Phe Asp Ser Gly Asp Arg 
            180                 185                 190         


Glu Leu Glu Glu Glu Gly Lys Arg Phe Arg Glu Ile Leu Asp Glu Thr 
        195                 200                 205             


Leu Leu Leu Ala Gly Ala Ser Asn Val Gly Asp Tyr Leu Pro Ile Leu 
    210                 215                 220                 


Asn Trp Leu Gly Val Lys Ser Leu Glu Lys Lys Leu Ile Ala Leu Gln 
225                 230                 235                 240 


Lys Lys Arg Asp Asp Phe Phe Gln Gly Leu Ile Glu Gln Val Arg Lys 
                245                 250                 255     


Ser Arg Gly Ala Lys Val Gly Lys Gly Arg Lys Thr Met Ile Glu Leu 
            260                 265                 270         


Leu Leu Ser Leu Gln Glu Ser Glu Pro Glu Tyr Tyr Thr Asp Ala Met 
        275                 280                 285             


Ile Arg Ser Phe Val Leu Gly Leu Leu Ala Ala Gly Ser Asp Thr Ser 
    290                 295                 300                 


Ala Gly Thr Met Glu Trp Ala Met Ser Leu Leu Val Asn His Pro His 
305                 310                 315                 320 


Val Leu Lys Lys Ala Gln Ala Glu Ile Asp Arg Val Ile Gly Asn Asn 
                325                 330                 335     


Arg Leu Ile Asp Glu Ser Asp Ile Gly Asn Ile Pro Tyr Ile Gly Cys 
            340                 345                 350         


Ile Ile Asn Glu Thr Leu Arg Leu Tyr Pro Ala Gly Pro Leu Leu Phe 
        355                 360                 365             


Pro His Glu Ser Ser Ala Asp Cys Val Ile Ser Gly Tyr Asn Ile Pro 
    370                 375                 380                 


Arg Gly Thr Met Leu Ile Val Asn Gln Trp Ala Ile His His Asp Pro 
385                 390                 395                 400 


Lys Val Trp Asp Asp Pro Glu Thr Phe Lys Pro Glu Arg Phe Gln Gly 
                405                 410                 415     


Leu Glu Gly Thr Arg Asp Gly Phe Lys Leu Met Pro Phe Gly Ser Gly 
            420                 425                 430         


Arg Arg Gly Cys Pro Gly Glu Gly Leu Ala Ile Arg Leu Leu Gly Met 
        435                 440                 445             


Thr Leu Gly Ser Val Ile Gln Cys Phe Asp Trp Glu Arg Val Gly Asp 
    450                 455                 460                 


Glu Met Val Asp Met Thr Glu Gly Leu Gly Val Thr Leu Pro Lys Ala 
465                 470                 475                 480 


Val Pro Leu Val Ala Lys Cys Lys Pro Arg Ser Glu Met Thr Asn Leu 
                485                 490                 495     


Leu Ser Glu Leu 
            500 


