                         SEQUENCE LISTING

<110>  Janssen Biotech, Inc.
       Rajkumar Ganesan
       Iqbal S. Grewal
       Sanjaya Singh
 
<120>  MATERIALS AND METHODS FOR MODULATING DELTA CHAIN MEDIATED
       IMMUNITY

<130>  14620-109-228/JBI6271WOPCT1

<140>
<141>

<150>  US 62/989,111
<151>  2020-03-13

<160>  20    

<170>  PatentIn version 3.5

<210>  1
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR1 Sequence of anti-TRDV2 mAb for antibody B6

<400>  1

Glu Asn Pro Met His 
1               5   


<210>  2
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR2 Sequence of anti-TRDV2 mAb for antibody B6

<400>  2

Ile Ile Tyr Thr Asp Thr Gly Glu Pro Thr Tyr Ala Ala Glu Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  3
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR3 Sequence of anti-TRDV2 mAb for antibody B6

<400>  3

Glu Gly Gly Ser His Trp Tyr Leu Asp Val 
1               5                   10  


<210>  4
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCDR1 Sequence of anti-TRDV2 mAb of antibody B6

<400>  4

Arg Ala Ser Glu Ser Val Asp Lys Tyr Gly Ile Ser Phe Met Asn 
1               5                   10                  15  


<210>  5
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCDR2 Sequence of anti-TRDV2 mAb of antibody B6

<400>  5

Ala Ala Ser Asn Gln Gly Ser 
1               5           


<210>  6
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCDR3 Sequence of anti-TRDV2 mAb of antibody B6

<400>  6

Gln Gln Ser Lys Glu Val Pro Arg Thr 
1               5                   


<210>  7
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain sequence of anti-TRDV2 mAb of antibody B6

<400>  7

Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ile Phe Thr Glu Asn 
            20                  25                  30          


Pro Met His Trp Val Lys Gln Ala Pro Gly Lys Gly Phe Lys Trp Met 
        35                  40                  45              


Gly Ile Ile Tyr Thr Asp Thr Gly Glu Pro Thr Tyr Ala Ala Glu Phe 
    50                  55                  60                  


Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Asn Tyr Ile Lys Thr Glu Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Val Arg Glu Gly Gly Ser His Trp Tyr Leu Asp Val Trp Gly Thr Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser 
        115                 


<210>  8
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain sequence of anti-TRDV2 mAb of antibody B6

<400>  8

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Lys Tyr 
            20                  25                  30          


Gly Ile Ser Phe Met Asn Trp Phe Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Ala Ala Ser Asn Gln Gly Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ser Leu Asn Ile His 
65                  70                  75                  80  


Pro Met Glu Glu Asp Asp Thr Ala Met Tyr Phe Cys Gln Gln Ser Lys 
                85                  90                  95      


Glu Val Pro Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  9
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR1 Sequence of anti-CD33 mAb of antibody C33B904

<400>  9

Asp Tyr Ala Met His 
1               5   


<210>  10
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR2 Sequence of anti-CD33 mAb of antibody C33B904

<400>  10

Gly Ile Gly Trp Ser Gly Gly Ser Ile Val Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  11
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR3 Sequence of anti-CD33 mAb of antibody C33B904

<400>  11

Asp Ser Pro Tyr Gly Asp Phe Phe Asp Tyr 
1               5                   10  


<210>  12
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCDR1 Sequence of anti-CD33 mAb of antibody C33B904

<400>  12

Lys Ser Ser Gln Thr Val Phe Tyr Ser Ser Asn Asn Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210>  13
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCDR2 Sequence of anti-CD33 mAb of antibody C33B904

<400>  13

Trp Ala Ser Thr Arg Lys Ser 
1               5           


<210>  14
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCDR3 Sequence of anti-CD33 mAb of antibody C33B904

<400>  14

Gln His Tyr Tyr Ser Thr Pro Tyr Thr 
1               5                   


<210>  15
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain sequence of anti-CD33 mAb of antibody C33B904

<400>  15

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Gly Trp Ser Gly Gly Ser Ile Val Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Ser Pro Tyr Gly Asp Phe Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  16
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain sequence of anti-CD33 mAb of antibody C33B904

<400>  16

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Thr Val Phe Tyr Ser 
            20                  25                  30          


Ser Asn Asn Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Ser Trp Ala Ser Thr Arg Lys Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Val Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln His 
                85                  90                  95      


Tyr Tyr Ser Thr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  17
<211>  237
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANTI-TRDV2 (light chain) sequence expressed in CHO Cells

<400>  17

Met Ala Trp Val Trp Thr Leu Leu Phe Leu Met Ala Ala Ala Gln Ser 
1               5                   10                  15      


Ile Gln Ala Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val 
            20                  25                  30          


Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val 
        35                  40                  45              


Asp Lys Tyr Gly Ile Ser Phe Met Asn Trp Phe Gln Gln Lys Pro Gly 
    50                  55                  60                  


Gln Pro Pro Lys Leu Leu Ile Tyr Ala Ala Ser Asn Gln Gly Ser Gly 
65                  70                  75                  80  


Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ser Leu 
                85                  90                  95      


Asn Ile His Pro Met Glu Glu Asp Asp Thr Ala Met Tyr Phe Cys Gln 
            100                 105                 110         


Gln Ser Lys Glu Val Pro Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu 
        115                 120                 125             


Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser 
    130                 135                 140                 


Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn 
145                 150                 155                 160 


Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala 
                165                 170                 175     


Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys 
            180                 185                 190         


Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp 
        195                 200                 205             


Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu 
    210                 215                 220                 


Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235         


<210>  18
<211>  468
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANTI-TRDV2 ('hole' arm) sequence expressed in CHO Cells

<400>  18

Met Ala Trp Val Trp Thr Leu Leu Phe Leu Met Ala Ala Ala Gln Ser 
1               5                   10                  15      


Ile Gln Ala Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys 
            20                  25                  30          


Pro Gly Glu Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ile Phe 
        35                  40                  45              


Thr Glu Asn Pro Met His Trp Val Lys Gln Ala Pro Gly Lys Gly Phe 
    50                  55                  60                  


Lys Trp Met Gly Ile Ile Tyr Thr Asp Thr Gly Glu Pro Thr Tyr Ala 
65                  70                  75                  80  


Ala Glu Phe Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser 
                85                  90                  95      


Thr Ala Tyr Leu Gln Ile Asn Tyr Ile Lys Thr Glu Asp Thr Ala Thr 
            100                 105                 110         


Tyr Phe Cys Val Arg Glu Gly Gly Ser His Trp Tyr Leu Asp Val Trp 
        115                 120                 125             


Gly Thr Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
    130                 135                 140                 


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
145                 150                 155                 160 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
                165                 170                 175     


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
            180                 185                 190         


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
        195                 200                 205             


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
    210                 215                 220                 


His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser 
225                 230                 235                 240 


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala 
                245                 250                 255     


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
            260                 265                 270         


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
        275                 280                 285             


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
    290                 295                 300                 


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
305                 310                 315                 320 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
                325                 330                 335     


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
            340                 345                 350         


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
        355                 360                 365             


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
    370                 375                 380                 


Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
385                 390                 395                 400 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
                405                 410                 415     


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr 
            420                 425                 430         


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
        435                 440                 445             


Met His Glu Ala Leu His Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu 
    450                 455                 460                 


Ser Pro Gly Lys 
465             


<210>  19
<211>  503
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANTI-CD33 scFv ('knob' arm) sequence expressed in CHO Cells

<400>  19

Met Ala Trp Val Trp Thr Leu Leu Phe Leu Met Ala Ala Ala Gln Ser 
1               5                   10                  15      


Ile Gln Ala Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val 
            20                  25                  30          


Ser Leu Gly Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Thr Val 
        35                  40                  45              


Phe Tyr Ser Ser Asn Asn Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys 
    50                  55                  60                  


Pro Gly Gln Pro Pro Lys Leu Leu Ile Ser Trp Ala Ser Thr Arg Lys 
65                  70                  75                  80  


Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
                85                  90                  95      


Thr Leu Thr Val Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr 
            100                 105                 110         


Cys Gln His Tyr Tyr Ser Thr Pro Tyr Thr Phe Gly Gln Gly Thr Lys 
        115                 120                 125             


Leu Glu Ile Lys Gly Gly Ser Glu Gly Lys Ser Ser Gly Ser Gly Ser 
    130                 135                 140                 


Glu Ser Lys Ser Thr Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly 
145                 150                 155                 160 


Gly Gly Leu Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala 
                165                 170                 175     


Ser Gly Phe Thr Phe Asp Asp Tyr Ala Met His Trp Val Arg Gln Ala 
            180                 185                 190         


Pro Gly Lys Gly Leu Glu Trp Val Ser Gly Ile Gly Trp Ser Gly Gly 
        195                 200                 205             


Ser Ile Val Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg 
    210                 215                 220                 


Asp Asn Ala Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala 
225                 230                 235                 240 


Glu Asp Thr Ala Leu Tyr Tyr Cys Ala Lys Asp Ser Pro Tyr Gly Asp 
                245                 250                 255     


Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Glu 
            260                 265                 270         


Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
        275                 280                 285             


Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
    290                 295                 300                 


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
305                 310                 315                 320 


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
                325                 330                 335     


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
            340                 345                 350         


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
        355                 360                 365             


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
    370                 375                 380                 


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
385                 390                 395                 400 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys 
                405                 410                 415     


Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
            420                 425                 430         


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
        435                 440                 445             


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
    450                 455                 460                 


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
465                 470                 475                 480 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
                485                 490                 495     


Leu Ser Leu Ser Pro Gly Lys 
            500             


<210>  20
<211>  502
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANTI-RSV scFv ('knob' arm) sequence expressed in CHO Cells

<400>  20

Met Ala Trp Val Trp Thr Leu Leu Phe Leu Met Ala Ala Ala Gln Ser 
1               5                   10                  15      


Ile Gln Ala Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val 
            20                  25                  30          


Ser Leu Gly Glu Arg Ala Thr Ile Asn Cys Arg Ala Ser Gln Ser Val 
        35                  40                  45              


Asp Tyr Asn Gly Ile Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly 
    50                  55                  60                  


Gln Pro Pro Lys Leu Leu Ile Tyr Ala Ala Ser Asn Pro Glu Ser Gly 
65                  70                  75                  80  


Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
                85                  90                  95      


Thr Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln 
            100                 105                 110         


Gln Ile Ile Glu Asp Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu 
        115                 120                 125             


Ile Lys Gly Gly Ser Glu Gly Lys Ser Ser Gly Ser Gly Ser Glu Ser 
    130                 135                 140                 


Lys Ser Thr Gly Gly Ser Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr 
145                 150                 155                 160 


Leu Val Lys Pro Thr Gln Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly 
                165                 170                 175     


Phe Ser Leu Ser Thr Ser Gly Met Gly Val Ser Trp Ile Arg Gln Pro 
            180                 185                 190         


Pro Gly Lys Ala Leu Glu Trp Leu Ala His Ile Tyr Trp Asp Asp Asp 
        195                 200                 205             


Lys Arg Tyr Asn Pro Ser Leu Lys Ser Arg Leu Thr Ile Thr Lys Asp 
    210                 215                 220                 


Thr Ser Lys Asn Gln Val Val Leu Thr Met Thr Asn Met Asp Pro Val 
225                 230                 235                 240 


Asp Thr Ala Thr Tyr Tyr Cys Ala Arg Leu Tyr Gly Phe Thr Tyr Gly 
                245                 250                 255     


Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Glu Pro 
            260                 265                 270         


Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
        275                 280                 285             


Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
    290                 295                 300                 


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
305                 310                 315                 320 


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
                325                 330                 335     


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
            340                 345                 350         


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
        355                 360                 365             


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
    370                 375                 380                 


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
385                 390                 395                 400 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
                405                 410                 415     


Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
            420                 425                 430         


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
        435                 440                 445             


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
    450                 455                 460                 


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
465                 470                 475                 480 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
                485                 490                 495     


Ser Leu Ser Pro Gly Lys 
            500         


