                         SEQUENCE LISTING

<110>  ImmunityBio, Inc.
 
<120>  Proteinaceous Therapeutics

<130>  PAT.005229.WO001 // 17768IB-000108-WO-POA

<150>  16/880,804
<151>  2020-05-21

<150>  62/988,328
<151>  2020-03-11

<150>  62/991,504
<151>  2020-03-18

<150>  63/016,048
<151>  2020-04-27

<150>  63/016,241
<151>  2020-04-27

<150>  63/022,146
<151>  2020-05-08

<150>  63/036,445
<151>  2020-06-09

<150>  63/080,887
<151>  2020-09-21

<150>  63/082,145
<151>  2020-09-23

<150>  63/121,102
<151>  2020-12-03

<160>  237   

<170>  PatentIn version 3.5

<210>  1
<211>  327
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Receptor binding domain of SARS-CoV-2 Spike, fused to an 
       endosomal targeting sequence

<400>  1

Met Leu Leu Leu Pro Phe Gln Leu Leu Ala Val Leu Phe Pro Gly Gly 
1               5                   10                  15      


Asn Ser Glu Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn 
            20                  25                  30          


Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe 
        35                  40                  45              


Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala 
    50                  55                  60                  


Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys 
65                  70                  75                  80  


Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val 
                85                  90                  95      


Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala 
            100                 105                 110         


Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp 
        115                 120                 125             


Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser 
    130                 135                 140                 


Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser 
145                 150                 155                 160 


Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala 
                165                 170                 175     


Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro 
            180                 185                 190         


Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro 
        195                 200                 205             


Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr 
    210                 215                 220                 


Val Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val 
225                 230                 235                 240 


Asn Phe Asn Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser 
                245                 250                 255     


Asn Lys Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp 
            260                 265                 270         


Thr Thr Asp Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile 
        275                 280                 285             


Thr Pro Cys Ser Met Leu Ile Pro Ile Ala Val Gly Gly Ala Leu Ala 
    290                 295                 300                 


Gly Leu Val Leu Ile Val Leu Ile Ala Tyr Leu Ile Gly Lys Lys His 
305                 310                 315                 320 


Cys Ser Tyr Gln Asp Ile Leu 
                325         


<210>  2
<211>  516
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SARS-CoV-2 N protein, fused to endosomal targeting sequence

<400>  2

Met Leu Leu Leu Pro Phe Gln Leu Leu Ala Val Leu Phe Pro Gly Gly 
1               5                   10                  15      


Asn Ser Glu Asp Tyr Lys Asp Asp Asp Asp Lys Gly Gly Gly Ser Gly 
            20                  25                  30          


Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Met Ser Asp Asn Gly 
        35                  40                  45              


Pro Gln Asn Gln Arg Asn Ala Pro Arg Ile Thr Phe Gly Gly Pro Ser 
    50                  55                  60                  


Asp Ser Thr Gly Ser Asn Gln Asn Gly Glu Arg Ser Gly Ala Arg Ser 
65                  70                  75                  80  


Lys Gln Arg Arg Pro Gln Gly Leu Pro Asn Asn Thr Ala Ser Trp Phe 
                85                  90                  95      


Thr Ala Leu Thr Gln His Gly Lys Glu Asp Leu Lys Phe Pro Arg Gly 
            100                 105                 110         


Gln Gly Val Pro Ile Asn Thr Asn Ser Ser Pro Asp Asp Gln Ile Gly 
        115                 120                 125             


Tyr Tyr Arg Arg Ala Thr Arg Arg Ile Arg Gly Gly Asp Gly Lys Met 
    130                 135                 140                 


Lys Asp Leu Ser Pro Arg Trp Tyr Phe Tyr Tyr Leu Gly Thr Gly Pro 
145                 150                 155                 160 


Glu Ala Gly Leu Pro Tyr Gly Ala Asn Lys Asp Gly Ile Ile Trp Val 
                165                 170                 175     


Ala Thr Glu Gly Ala Leu Asn Thr Pro Lys Asp His Ile Gly Thr Arg 
            180                 185                 190         


Asn Pro Ala Asn Asn Ala Ala Ile Val Leu Gln Leu Pro Gln Gly Thr 
        195                 200                 205             


Thr Leu Pro Lys Gly Phe Tyr Ala Glu Gly Ser Arg Gly Gly Ser Gln 
    210                 215                 220                 


Ala Ser Ser Arg Ser Ser Ser Arg Ser Arg Asn Ser Ser Arg Asn Ser 
225                 230                 235                 240 


Thr Pro Gly Ser Ser Arg Gly Thr Ser Pro Ala Arg Met Ala Gly Asn 
                245                 250                 255     


Gly Gly Asp Ala Ala Leu Ala Leu Leu Leu Leu Asp Arg Leu Asn Gln 
            260                 265                 270         


Leu Glu Ser Lys Met Ser Gly Lys Gly Gln Gln Gln Gln Gly Gln Thr 
        275                 280                 285             


Val Thr Lys Lys Ser Ala Ala Glu Ala Ser Lys Lys Pro Arg Gln Lys 
    290                 295                 300                 


Arg Thr Ala Thr Lys Ala Tyr Asn Val Thr Gln Ala Phe Gly Arg Arg 
305                 310                 315                 320 


Gly Pro Glu Gln Thr Gln Gly Asn Phe Gly Asp Gln Glu Leu Ile Arg 
                325                 330                 335     


Gln Gly Thr Asp Tyr Lys His Trp Pro Gln Ile Ala Gln Phe Ala Pro 
            340                 345                 350         


Ser Ala Ser Ala Phe Phe Gly Met Ser Arg Ile Gly Met Glu Val Thr 
        355                 360                 365             


Pro Ser Gly Thr Trp Leu Thr Tyr Thr Gly Ala Ile Lys Leu Asp Asp 
    370                 375                 380                 


Lys Asp Pro Asn Phe Lys Asp Gln Val Ile Leu Leu Asn Lys His Ile 
385                 390                 395                 400 


Asp Ala Tyr Lys Thr Phe Pro Pro Thr Glu Pro Lys Lys Asp Lys Lys 
                405                 410                 415     


Lys Lys Ala Asp Glu Thr Gln Ala Leu Pro Gln Arg Gln Lys Lys Gln 
            420                 425                 430         


Gln Thr Val Thr Leu Leu Pro Ala Ala Asp Leu Asp Asp Phe Ser Lys 
        435                 440                 445             


Gln Leu Gln Gln Ser Met Ser Ser Ala Asp Ser Thr Gln Ala Gly Pro 
    450                 455                 460                 


Gly Pro Gly Asn Leu Val Pro Met Val Ala Thr Val Gly Pro Gly Pro 
465                 470                 475                 480 


Gly Met Leu Ile Pro Ile Ala Val Gly Gly Ala Leu Ala Gly Leu Val 
                485                 490                 495     


Leu Ile Val Leu Ile Ala Tyr Leu Ile Gly Lys Lys His Cys Ser Tyr 
            500                 505                 510         


Gln Asp Ile Leu 
        515     


<210>  3
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-Spike Group 1, CDR-H1

<400>  3

Ser Ser Tyr Thr Met His 
1               5       


<210>  4
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-Spike Group 1, CDR-H2

<400>  4

Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr 
1               5                   10  


<210>  5
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-Spike Group 1, CDR-H3

<400>  5

Asp Leu Phe Asp Phe Trp Gly 
1               5           


<210>  6
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-Spike Group 1, CDR-L3

<400>  6

Asp Tyr Gly Phe Pro Leu 
1               5       


<210>  7
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-Spike Group 2, CDR-H1

<400>  7

Ser Asn Tyr Ala Met His 
1               5       


<210>  8
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-Spike Group 2, CDR-H2

<400>  8

Ala Ile Ser Gly Asn Gly Gly Ser Thr Gly 
1               5                   10  


<210>  9
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-Spike Group 2, CDR-H3

<400>  9

Asp Arg Trp Tyr Val Lys Asn Ala 
1               5               


<210>  10
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-Spike Group 2, CDR-L3

<400>  10

Leu Asp Gly Thr Pro Phe 
1               5       


<210>  11
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-Spike Group 3, CDR-H1

<400>  11

Ser Ser Tyr Ala Met His 
1               5       


<210>  12
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-Spike Group 3, CDR-H2

<400>  12

Ala Ile Tyr Gly Asn Gly Gly Ser Thr Asp 
1               5                   10  


<210>  13
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-Spike Group 3, CDR-H3

<400>  13

Asp Arg Tyr Met Leu Trp Met Ala 
1               5               


<210>  14
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-Spike Group 3, CDR-L3

<400>  14

Asp Thr Asp Asp Pro Leu 
1               5       


<210>  15
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-Spike Group 4, CDR-H1

<400>  15

Ser Ser Tyr Ala Met Ser 
1               5       


<210>  16
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-Spike Group 4, CDR-H2

<400>  16

Ile Ile Ser Gly Ser Gly Gly Ser Thr Tyr 
1               5                   10  


<210>  17
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-Spike Group 4, CDR-H3

<400>  17

Asp Leu Tyr Gly Leu Trp Asn Ala 
1               5               


<210>  18
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-Spike Group 4, CDR-L3

<400>  18

Asp Ser Ala Asp Pro Arg 
1               5       


<210>  19
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-Spike Group 5, CDR-H1

<400>  19

Ser Ser Tyr Ala Met Ser 
1               5       


<210>  20
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-Spike Group 5, CDR-H2

<400>  20

Ala Ile Arg Gly Ser Gly Gly Ser Thr Tyr 
1               5                   10  


<210>  21
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-Spike Group 5, CDR-H3

<400>  21

Asp Arg Trp Cys Arg Cys Ile Ala 
1               5               


<210>  22
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-Spike Group 5, CDR-L3

<400>  22

Val Ala Ala Asn Pro Tyr 
1               5       


<210>  23
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-Spike Group 6, CDR-H1

<400>  23

Ser Ser Tyr Ala Met Ser 
1               5       


<210>  24
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-Spike Group 6, CDR-H2

<400>  24

Ala Ile Ser Gly Ser Gly Gly Ser Thr Asn 
1               5                   10  


<210>  25
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-Spike Group 6, CDR-H3

<400>  25

Asp Leu Trp Gly Leu Ala Phe Ala 
1               5               


<210>  26
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-Spike Group 6, CDR-L3

<400>  26

Asp Ser Ser Asn Pro Trp 
1               5       


<210>  27
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-Spike Group 7, CDR-H1

<400>  27

Ser Ser Tyr Tyr Met His 
1               5       


<210>  28
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-Spike Group 7, CDR-H2

<400>  28

Ala Ile Ser Gly Ser Gly Gly Tyr Thr Tyr 
1               5                   10  


<210>  29
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-Spike Group 7, CDR-H3

<400>  29

Asp Arg Asp His Ala Tyr Asp Trp Gly 
1               5                   


<210>  30
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-Spike Group 7, CDR-L3

<400>  30

Trp Ala Asp Trp Pro Leu 
1               5       


<210>  31
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-Spike Group 8, CDR-H1

<400>  31

Ser Ser Tyr Ala Met His 
1               5       


<210>  32
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-Spike Group 8, CDR-H2

<400>  32

Ala Ile Ser Trp Ser Gly Arg Ser Thr Tyr 
1               5                   10  


<210>  33
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-Spike Group 8, CDR-H3

<400>  33

Asp Leu Ser Ser Asn Trp Gly Cys Gly 
1               5                   


<210>  34
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-Spike Group 8, CDR-L3

<400>  34

Ser Ala Asp Thr Pro Phe 
1               5       


<210>  35
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-Spike Group 9, CDR-H1

<400>  35

Ser Ser Tyr Ala Met Thr 
1               5       


<210>  36
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-Spike Group 9, CDR-H2

<400>  36

Tyr Ile Ser Gly Ser Gly Gly Gly Thr Tyr 
1               5                   10  


<210>  37
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-Spike Group 9, CDR-H3

<400>  37

Asp Arg Trp Ala Ser Gly Trp Leu Ala 
1               5                   


<210>  38
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-Spike Group 9, CDR-L3

<400>  38

Ala Tyr Ala Tyr Pro Leu 
1               5       


<210>  39
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-Spike Group 10, CDR-H1

<400>  39

Ser Ser Tyr Tyr Met His 
1               5       


<210>  40
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-Spike Group 10, CDR-H2

<400>  40

Ala Ile Ser Gly Ser Gly Gly Tyr Thr Tyr 
1               5                   10  


<210>  41
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-Spike Group 10, CDR-H3

<400>  41

Asp Leu Trp Gly Ser Gly Phe Phe Ala 
1               5                   


<210>  42
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-Spike Group 10, CDR-L3

<400>  42

Asp Ala Gly Thr Pro Leu 
1               5       


<210>  43
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-Spike Group 11, CDR-H1

<400>  43

Ser Ser Tyr Ala Met Ser 
1               5       


<210>  44
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-Spike Group 11, CDR-H2

<400>  44

Leu Ile Ser Gly Ser Gly Gly Ser Thr Tyr 
1               5                   10  


<210>  45
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-Spike Group 11, CDR-H3

<400>  45

Asp Leu Trp Gly Ser Gly Phe Phe Ala 
1               5                   


<210>  46
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-Spike Group 11, CDR-L3

<400>  46

Asp Ala Gly Thr Pro Leu 
1               5       


<210>  47
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-Spike Group 12, CDR-H1

<400>  47

Ser Ser Tyr Ala Met His 
1               5       


<210>  48
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-Spike Group 12, CDR-H2

<400>  48

Leu Ile Ser Gly Ser Gly Gly Ser Thr Asp 
1               5                   10  


<210>  49
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-Spike Group 12, CDR-H3

<400>  49

Asp Leu Val Val Pro Tyr Gly Pro Gly 
1               5                   


<210>  50
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-Spike Group 12, CDR-L3

<400>  50

Ser Thr Asp Gly Pro Leu 
1               5       


<210>  51
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-Spike Group 13, CDR-H1

<400>  51

Ser Ser Tyr Ala Met Ser 
1               5       


<210>  52
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-Spike Group 13, CDR-H2

<400>  52

Ala Ile Ser Gly Ser Gly Gly Ser Thr Ser 
1               5                   10  


<210>  53
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-Spike Group 13, CDR-H3

<400>  53

Asp Leu Phe Met Glu Phe Met Trp Ala 
1               5                   


<210>  54
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-Spike Group 13, CDR-L3

<400>  54

Trp Ala Asn Leu Pro Tyr 
1               5       


<210>  55
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-Spike Group 14, CDR-H1

<400>  55

Ser Ser Tyr Ala Met Thr 
1               5       


<210>  56
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-Spike Group 14, CDR-H2

<400>  56

Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr 
1               5                   10  


<210>  57
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-Spike Group 14, CDR-H3

<400>  57

Asp Arg Trp Trp Asp Ser Leu Trp Val Gly 
1               5                   10  


<210>  58
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-Spike Group 14, CDR-L3

<400>  58

Thr Asp Asp Asn Pro Phe 
1               5       


<210>  59
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-Spike Group 15, CDR-H1

<400>  59

Ser Ser Tyr Ala Met Ser 
1               5       


<210>  60
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-Spike Group 15, CDR-H2

<400>  60

Ala Ile Ser Asn Ser Gly Gly Glu Thr Tyr 
1               5                   10  


<210>  61
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-Spike Group 15, CDR-H3

<400>  61

Asp Leu Trp Val Glu Asn Leu Trp Trp Gly 
1               5                   10  


<210>  62
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-Spike Group 15, CDR-L3

<400>  62

Thr Asp Asp Ile Pro Phe 
1               5       


<210>  63
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-Spike Group 16, CDR-H1

<400>  63

Ser Ser Tyr Thr Met His 
1               5       


<210>  64
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-Spike Group 16, CDR-H2

<400>  64

Ala Ile Ser Gly Ser Gly Gly Tyr Thr Tyr 
1               5                   10  


<210>  65
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-Spike Group 16, CDR-H3

<400>  65

Asp Arg Asp Leu Leu Trp Met Gly Trp Ala 
1               5                   10  


<210>  66
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-Spike Group 16, CDR-L3

<400>  66

Tyr Ala Asn Trp Pro Leu 
1               5       


<210>  67
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-Spike Group 17, CDR-H1

<400>  67

Ser Ser Tyr Ala Met His 
1               5       


<210>  68
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-Spike Group 17, CDR-H2

<400>  68

Ala Ile Trp Gly Ser Gly Ser Asn Thr Tyr 
1               5                   10  


<210>  69
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-Spike Group 17, CDR-H3

<400>  69

Gly Arg Asp Leu Ala Ala Phe Thr Lys Thr Ala 
1               5                   10      


<210>  70
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-Spike Group 17, CDR-L3

<400>  70

His Asp Ala Leu Pro Trp 
1               5       


<210>  71
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-Spike Group 18, CDR-H1

<400>  71

Asn Ser Tyr Ala Met His 
1               5       


<210>  72
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-Spike Group 18, CDR-H2

<400>  72

Ala Ile Ser Gly Ser Gly Gly Arg Thr Tyr 
1               5                   10  


<210>  73
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-Spike Group 18, CDR-H3

<400>  73

Asp Leu Arg Ser Ser Trp Val Phe Tyr Thr Leu Ala 
1               5                   10          


<210>  74
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-Spike Group 18, CDR-L3

<400>  74

Gly Tyr Thr Ile Pro Leu 
1               5       


<210>  75
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-Spike Group 19, CDR-H1

<400>  75

Ser Asn Tyr Ala Met His 
1               5       


<210>  76
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-Spike Group 19, CDR-H2

<400>  76

Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr 
1               5                   10  


<210>  77
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-Spike Group 19, CDR-H3

<400>  77

Asp Leu Ser Phe Trp Leu Thr Tyr His Leu Ala Ser Ala 
1               5                   10              


<210>  78
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-Spike Group 19, CDR-L3

<400>  78

Ser Tyr Ser Asp Pro Leu 
1               5       


<210>  79
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-Spike Group 20, CDR-H1

<400>  79

Ser Ser Tyr Ala Met His 
1               5       


<210>  80
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-Spike Group 20, CDR-H2

<400>  80

Ala Ile Asp Gly Asn Gly Gly Tyr Thr Tyr 
1               5                   10  


<210>  81
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-Spike Group 20, CDR-H3

<400>  81

Gly Arg Val Ser Ala Ser Trp Tyr Gly Ala Asp Val Gly 
1               5                   10              


<210>  82
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-Spike Group 20, CDR-L3

<400>  82

Ser Tyr Gly Ile Pro Leu 
1               5       


<210>  83
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-RBD Group 1, CDR-H1

<400>  83

Asn Ser Tyr Ala Met His 
1               5       


<210>  84
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-RBD Group 1, CDR-H2

<400>  84

Ala Ile Ser Gly Asn Gly Gly Ser Thr Tyr 
1               5                   10  


<210>  85
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-RBD Group 1, CDR-H3

<400>  85

Asp Arg Cys Phe Ala Ile Trp Gly 
1               5               


<210>  86
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-RBD Group 1, CDR-L3

<400>  86

Tyr Asp Asp His Pro Phe 
1               5       


<210>  87
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-RBD Group 2, CDR-H1

<400>  87

Ser Ser Tyr Ala Met Asn 
1               5       


<210>  88
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-RBD Group 2, CDR-H2

<400>  88

Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr 
1               5                   10  


<210>  89
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-RBD Group 2, CDR-H3

<400>  89

Gly Arg Val Trp Val Trp Val Ala 
1               5               


<210>  90
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-RBD Group 2, CDR-L3

<400>  90

Trp Asp Ala Leu Pro Arg 
1               5       


<210>  91
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-RBD Group 3, CDR-H1

<400>  91

Gly Ser Tyr Ala Met His 
1               5       


<210>  92
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-RBD Group 3, CDR-H2

<400>  92

Gly Ile Ser Gly Ser Gly Gly Tyr Thr Tyr 
1               5                   10  


<210>  93
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-RBD Group 3, CDR-H3

<400>  93

Asp Arg Leu Asn Met Phe Leu Ala 
1               5               


<210>  94
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-RBD Group 3, CDR-L3

<400>  94

Asp Ala Gly Thr Pro Leu 
1               5       


<210>  95
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-RBD Group 4, CDR-H1

<400>  95

Ser Ser Tyr Ala Met Asn 
1               5       


<210>  96
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-RBD Group 4, CDR-H2

<400>  96

Ala Ile Ser Gly Gly Gly Gly Asn Thr Tyr 
1               5                   10  


<210>  97
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-RBD Group 4, CDR-H3

<400>  97

Asp Leu Arg Cys Arg Pro Gly Ala 
1               5               


<210>  98
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-RBD Group 4, CDR-L3

<400>  98

Leu Tyr Ser Asp Pro Tyr 
1               5       


<210>  99
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-RBD Group 5, CDR-H1

<400>  99

Ser Ser Tyr Ala Met Ser 
1               5       


<210>  100
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-RBD Group 5, CDR-H2

<400>  100

Leu Ile Ser Gly Ser Gly Gly Ser Thr Tyr 
1               5                   10  


<210>  101
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-RBD Group 5, CDR-H3

<400>  101

Asp Leu Trp Gly Ser Gly Phe Phe Ala 
1               5                   


<210>  102
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-RBD Group 5, CDR-L3

<400>  102

Asp Ala Gly Thr Pro Leu 
1               5       


<210>  103
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-RBD Group 6, CDR-H1

<400>  103

Ser Ala Tyr Ala Met His 
1               5       


<210>  104
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-RBD Group 6, CDR-H2

<400>  104

Ala Ile Trp Gly Ser Gly Gly Ser Thr Tyr 
1               5                   10  


<210>  105
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-RBD Group 6, CDR-H3

<400>  105

Asp Leu Trp Met Ala Met Trp Phe Gly 
1               5                   


<210>  106
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-RBD Group 6, CDR-L3

<400>  106

Arg Ser Thr Tyr Pro Leu 
1               5       


<210>  107
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-RBD Group 7, CDR-H1

<400>  107

Ser Asn Tyr Ala Met His 
1               5       


<210>  108
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-RBD Group 7, CDR-H2

<400>  108

Ala Ile Ser Trp Ser Gly Gly Ser Thr Tyr 
1               5                   10  


<210>  109
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-RBD Group 7, CDR-H3

<400>  109

Asp Arg Phe Tyr Ile Val Leu Leu Gly 
1               5                   


<210>  110
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-RBD Group 7, CDR-L3

<400>  110

Arg Asp Ala Gly Pro Phe 
1               5       


<210>  111
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-RBD Group 8, CDR-H1

<400>  111

Ser Ser Tyr Ala Met Ser 
1               5       


<210>  112
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-RBD Group 8, CDR-H2

<400>  112

Ala Ile Ser Ser Ser Gly Gly Ser Thr Asn 
1               5                   10  


<210>  113
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-RBD Group 8, CDR-H3

<400>  113

Asp Leu Trp Ser Glu Arg Val Trp Phe Gly 
1               5                   10  


<210>  114
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-RBD Group 8, CDR-L3

<400>  114

Val Asp Asn Ala Pro Tyr 
1               5       


<210>  115
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-RBD Group 9, CDR-H1

<400>  115

Ser Ser Tyr Ala Met His 
1               5       


<210>  116
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-RBD Group 9, CDR-H2

<400>  116

Ala Ile Trp Gly Ser Gly Ser Asn Thr Tyr 
1               5                   10  


<210>  117
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-RBD Group 9, CDR-H3

<400>  117

Gly Arg Asp Leu Ala Ala Phe Thr Lys Thr Ala 
1               5                   10      


<210>  118
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-RBD Group 9, CDR-L3

<400>  118

His Asp Ala Leu Pro Trp 
1               5       


<210>  119
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-RBD Group 10, CDR-H1

<400>  119

Ser Ser Tyr Ala Met Asn 
1               5       


<210>  120
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-RBD Group 10, CDR-H2

<400>  120

Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr 
1               5                   10  


<210>  121
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-RBD Group 10, CDR-H3

<400>  121

Asp Leu Leu Trp Thr Ser Lys Ala Val Trp Trp Gly 
1               5                   10          


<210>  122
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-RBD Group 10, CDR-L3

<400>  122

Ser Ala Thr Met Pro Trp 
1               5       


<210>  123
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-RBD Group 11, CDR-H1

<400>  123

Ser Ser Tyr Ala Met Thr 
1               5       


<210>  124
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-RBD Group 11, CDR-H2

<400>  124

Ala Ile Asp Gly Asn Gly Gly Ser Thr Ser 
1               5                   10  


<210>  125
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-RBD Group 11, CDR-H3

<400>  125

Asp Leu Gly Phe Met Thr Ile Val Ala Phe Ala Ala 
1               5                   10          


<210>  126
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-RBD Group 11, CDR-L3

<400>  126

Ser Tyr Asp Arg Pro Trp 
1               5       


<210>  127
<211>  29
<212>  PRT
<213>  Homo sapiens

<400>  127

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
            20                  25                  


<210>  128
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  128

Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser 
1               5                   10                  


<210>  129
<211>  39
<212>  PRT
<213>  Homo sapiens

<400>  129

Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser 
1               5                   10                  15      


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
            20                  25                  30          


Ala Val Tyr Tyr Cys Ala Arg 
        35                  


<210>  130
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  130

Phe Asp Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10                  


<210>  131
<211>  90
<212>  PRT
<213>  Homo sapiens

<400>  131

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln 
                85                  90  


<210>  132
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  132

Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
1               5                   10      


<210>  133
<211>  419
<212>  PRT
<213>  SARS CoV

<400>  133

Met Ser Asp Asn Gly Pro Gln Asn Gln Arg Asn Ala Pro Arg Ile Thr 
1               5                   10                  15      


Phe Gly Gly Pro Ser Asp Ser Thr Gly Ser Asn Gln Asn Gly Glu Arg 
            20                  25                  30          


Ser Gly Ala Arg Ser Lys Gln Arg Arg Pro Gln Gly Leu Pro Asn Asn 
        35                  40                  45              


Thr Ala Ser Trp Phe Thr Ala Leu Thr Gln His Gly Lys Glu Asp Leu 
    50                  55                  60                  


Lys Phe Pro Arg Gly Gln Gly Val Pro Ile Asn Thr Asn Ser Ser Pro 
65                  70                  75                  80  


Asp Asp Gln Ile Gly Tyr Tyr Arg Arg Ala Thr Arg Arg Ile Arg Gly 
                85                  90                  95      


Gly Asp Gly Lys Met Lys Asp Leu Ser Pro Arg Trp Tyr Phe Tyr Tyr 
            100                 105                 110         


Leu Gly Thr Gly Pro Glu Ala Gly Leu Pro Tyr Gly Ala Asn Lys Asp 
        115                 120                 125             


Gly Ile Ile Trp Val Ala Thr Glu Gly Ala Leu Asn Thr Pro Lys Asp 
    130                 135                 140                 


His Ile Gly Thr Arg Asn Pro Ala Asn Asn Ala Ala Ile Val Leu Gln 
145                 150                 155                 160 


Leu Pro Gln Gly Thr Thr Leu Pro Lys Gly Phe Tyr Ala Glu Gly Ser 
                165                 170                 175     


Arg Gly Gly Ser Gln Ala Ser Ser Arg Ser Ser Ser Arg Ser Arg Asn 
            180                 185                 190         


Ser Ser Arg Asn Ser Thr Pro Gly Ser Ser Arg Gly Thr Ser Pro Ala 
        195                 200                 205             


Arg Met Ala Gly Asn Gly Gly Asp Ala Ala Leu Ala Leu Leu Leu Leu 
    210                 215                 220                 


Asp Arg Leu Asn Gln Leu Glu Ser Lys Met Ser Gly Lys Gly Gln Gln 
225                 230                 235                 240 


Gln Gln Gly Gln Thr Val Thr Lys Lys Ser Ala Ala Glu Ala Ser Lys 
                245                 250                 255     


Lys Pro Arg Gln Lys Arg Thr Ala Thr Lys Ala Tyr Asn Val Thr Gln 
            260                 265                 270         


Ala Phe Gly Arg Arg Gly Pro Glu Gln Thr Gln Gly Asn Phe Gly Asp 
        275                 280                 285             


Gln Glu Leu Ile Arg Gln Gly Thr Asp Tyr Lys His Trp Pro Gln Ile 
    290                 295                 300                 


Ala Gln Phe Ala Pro Ser Ala Ser Ala Phe Phe Gly Met Ser Arg Ile 
305                 310                 315                 320 


Gly Met Glu Val Thr Pro Ser Gly Thr Trp Leu Thr Tyr Thr Gly Ala 
                325                 330                 335     


Ile Lys Leu Asp Asp Lys Asp Pro Asn Phe Lys Asp Gln Val Ile Leu 
            340                 345                 350         


Leu Asn Lys His Ile Asp Ala Tyr Lys Thr Phe Pro Pro Thr Glu Pro 
        355                 360                 365             


Lys Lys Asp Lys Lys Lys Lys Ala Asp Glu Thr Gln Ala Leu Pro Gln 
    370                 375                 380                 


Arg Gln Lys Lys Gln Gln Thr Val Thr Leu Leu Pro Ala Ala Asp Leu 
385                 390                 395                 400 


Asp Asp Phe Ser Lys Gln Leu Gln Gln Ser Met Ser Ser Ala Asp Ser 
                405                 410                 415     


Thr Gln Ala 
            


<210>  134
<211>  422
<212>  PRT
<213>  SARS CoV-2

<400>  134

Met Ser Asp Asn Gly Pro Gln Ser Asn Gln Arg Ser Ala Pro Arg Ile 
1               5                   10                  15      


Thr Phe Gly Gly Pro Thr Asp Ser Thr Asp Asn Asn Gln Asn Gly Gly 
            20                  25                  30          


Arg Asn Gly Ala Arg Pro Lys Gln Arg Arg Pro Gln Gly Leu Pro Asn 
        35                  40                  45              


Asn Thr Ala Ser Trp Phe Thr Ala Leu Thr Gln His Gly Lys Glu Glu 
    50                  55                  60                  


Leu Arg Phe Pro Arg Gly Gln Gly Val Pro Ile Asn Thr Asn Ser Gly 
65                  70                  75                  80  


Pro Asp Asp Gln Ile Gly Tyr Tyr Arg Arg Ala Thr Arg Arg Val Arg 
                85                  90                  95      


Gly Gly Asp Gly Lys Met Lys Glu Leu Ser Pro Arg Trp Tyr Phe Tyr 
            100                 105                 110         


Tyr Leu Gly Thr Gly Pro Glu Ala Ser Leu Pro Tyr Gly Ala Asn Lys 
        115                 120                 125             


Glu Gly Ile Val Trp Val Ala Thr Glu Gly Ala Leu Asn Thr Pro Lys 
    130                 135                 140                 


Asp His Ile Gly Thr Arg Asn Pro Asn Asn Asn Ala Ala Thr Val Leu 
145                 150                 155                 160 


Gln Leu Pro Gln Gly Thr Thr Leu Pro Lys Gly Phe Tyr Ala Glu Gly 
                165                 170                 175     


Ser Arg Gly Gly Ser Gln Ala Ser Ser Arg Ser Ser Ser Arg Ser Arg 
            180                 185                 190         


Gly Asn Ser Arg Asn Ser Thr Pro Gly Ser Ser Arg Gly Asn Ser Pro 
        195                 200                 205             


Ala Arg Met Ala Ser Gly Gly Gly Glu Thr Ala Leu Ala Leu Leu Leu 
    210                 215                 220                 


Leu Asp Arg Leu Asn Gln Leu Glu Ser Lys Val Ser Gly Lys Gly Gln 
225                 230                 235                 240 


Gln Gln Gln Gly Gln Thr Val Thr Lys Lys Ser Ala Ala Glu Ala Ser 
                245                 250                 255     


Lys Lys Pro Arg Gln Lys Arg Thr Ala Thr Lys Gln Tyr Asn Val Thr 
            260                 265                 270         


Gln Ala Phe Gly Arg Arg Gly Pro Glu Gln Thr Gln Gly Asn Phe Gly 
        275                 280                 285             


Asp Gln Asp Leu Ile Arg Gln Gly Thr Asp Tyr Lys His Trp Pro Gln 
    290                 295                 300                 


Ile Ala Gln Phe Ala Pro Ser Ala Ser Ala Phe Phe Gly Met Ser Arg 
305                 310                 315                 320 


Ile Gly Met Glu Val Thr Pro Ser Gly Thr Trp Leu Thr Tyr His Gly 
                325                 330                 335     


Ala Ile Lys Leu Asp Asp Lys Asp Pro Gln Phe Lys Asp Asn Val Ile 
            340                 345                 350         


Leu Leu Asn Lys His Ile Asp Ala Tyr Lys Thr Phe Pro Pro Thr Glu 
        355                 360                 365             


Pro Lys Lys Asp Lys Lys Lys Lys Thr Asp Glu Ala Gln Pro Leu Pro 
    370                 375                 380                 


Gln Arg Gln Lys Lys Gln Pro Thr Val Thr Leu Leu Pro Ala Ala Asp 
385                 390                 395                 400 


Met Asp Asp Phe Ser Arg Gln Leu Gln Asn Ser Met Ser Gly Ala Ser 
                405                 410                 415     


Ala Asp Ser Thr Gln Ala 
            420         


<210>  135
<211>  805
<212>  PRT
<213>  Homo sapiens

<400>  135

Met Ser Ser Ser Ser Trp Leu Leu Leu Ser Leu Val Ala Val Thr Ala 
1               5                   10                  15      


Ala Gln Ser Thr Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Lys Phe 
            20                  25                  30          


Asn His Glu Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ser Trp 
        35                  40                  45              


Asn Tyr Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn 
    50                  55                  60                  


Ala Gly Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Leu Ala 
65                  70                  75                  80  


Gln Met Tyr Pro Leu Gln Glu Ile Gln Asn Leu Thr Val Lys Leu Gln 
                85                  90                  95      


Leu Gln Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys 
            100                 105                 110         


Ser Lys Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser 
        115                 120                 125             


Thr Gly Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu 
    130                 135                 140                 


Glu Pro Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu 
145                 150                 155                 160 


Arg Leu Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu 
                165                 170                 175     


Arg Pro Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg 
            180                 185                 190         


Ala Asn His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu 
        195                 200                 205             


Val Asn Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu 
    210                 215                 220                 


Asp Val Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu 
225                 230                 235                 240 


His Ala Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile 
                245                 250                 255     


Ser Pro Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly 
            260                 265                 270         


Arg Phe Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys 
        275                 280                 285             


Pro Asn Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala 
    290                 295                 300                 


Gln Arg Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu 
305                 310                 315                 320 


Pro Asn Met Thr Gln Gly Phe Trp Glu Asn Ser Met Leu Thr Asp Pro 
                325                 330                 335     


Gly Asn Val Gln Lys Ala Val Cys His Pro Thr Ala Trp Asp Leu Gly 
            340                 345                 350         


Lys Gly Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp 
        355                 360                 365             


Phe Leu Thr Ala His His Glu Met Gly His Ile Gln Tyr Asp Met Ala 
    370                 375                 380                 


Tyr Ala Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe 
385                 390                 395                 400 


His Glu Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys 
                405                 410                 415     


His Leu Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn 
            420                 425                 430         


Glu Thr Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly 
        435                 440                 445             


Thr Leu Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe 
    450                 455                 460                 


Lys Gly Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met 
465                 470                 475                 480 


Lys Arg Glu Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr 
                485                 490                 495     


Tyr Cys Asp Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe 
            500                 505                 510         


Ile Arg Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala 
        515                 520                 525             


Leu Cys Gln Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile 
    530                 535                 540                 


Ser Asn Ser Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu 
545                 550                 555                 560 


Gly Lys Ser Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala 
                565                 570                 575     


Lys Asn Met Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe 
            580                 585                 590         


Thr Trp Leu Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr 
        595                 600                 605             


Asp Trp Ser Pro Tyr Ala Asp Gln Ser Ile Lys Val Arg Ile Ser Leu 
    610                 615                 620                 


Lys Ser Ala Leu Gly Asp Lys Ala Tyr Glu Trp Asn Asp Asn Glu Met 
625                 630                 635                 640 


Tyr Leu Phe Arg Ser Ser Val Ala Tyr Ala Met Arg Gln Tyr Phe Leu 
                645                 650                 655     


Lys Val Lys Asn Gln Met Ile Leu Phe Gly Glu Glu Asp Val Arg Val 
            660                 665                 670         


Ala Asn Leu Lys Pro Arg Ile Ser Phe Asn Phe Phe Val Thr Ala Pro 
        675                 680                 685             


Lys Asn Val Ser Asp Ile Ile Pro Arg Thr Glu Val Glu Lys Ala Ile 
    690                 695                 700                 


Arg Met Ser Arg Ser Arg Ile Asn Asp Ala Phe Arg Leu Asn Asp Asn 
705                 710                 715                 720 


Ser Leu Glu Phe Leu Gly Ile Gln Pro Thr Leu Gly Pro Pro Asn Gln 
                725                 730                 735     


Pro Pro Val Ser Ile Trp Leu Ile Val Phe Gly Val Val Met Gly Val 
            740                 745                 750         


Ile Val Val Gly Ile Val Ile Leu Ile Phe Thr Gly Ile Arg Asp Arg 
        755                 760                 765             


Lys Lys Lys Asn Lys Ala Arg Ser Gly Glu Asn Pro Tyr Ala Ser Ile 
    770                 775                 780                 


Asp Ile Ser Lys Gly Glu Asn Asn Pro Gly Phe Gln Asn Thr Asp Asp 
785                 790                 795                 800 


Val Gln Thr Ser Phe 
                805 


<210>  136
<211>  805
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q24 mutant ACE2


<220>
<221>  MUTAGEN
<222>  (24)..(24)
<223>  The sequence here can be Ala, Arg, Asn, Asp, Cys, Glu, Gly, His, 
       Ile, Lys, Leu, Met, Phe, Pro, Ser, Thr, Trp, Tyr, or Val.

<400>  136

Met Ser Ser Ser Ser Trp Leu Leu Leu Ser Leu Val Ala Val Thr Ala 
1               5                   10                  15      


Ala Gln Ser Thr Ile Glu Glu Xaa Ala Lys Thr Phe Leu Asp Lys Phe 
            20                  25                  30          


Asn His Glu Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ser Trp 
        35                  40                  45              


Asn Tyr Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn 
    50                  55                  60                  


Ala Gly Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Leu Ala 
65                  70                  75                  80  


Gln Met Tyr Pro Leu Gln Glu Ile Gln Asn Leu Thr Val Lys Leu Gln 
                85                  90                  95      


Leu Gln Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys 
            100                 105                 110         


Ser Lys Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser 
        115                 120                 125             


Thr Gly Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu 
    130                 135                 140                 


Glu Pro Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu 
145                 150                 155                 160 


Arg Leu Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu 
                165                 170                 175     


Arg Pro Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg 
            180                 185                 190         


Ala Asn His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu 
        195                 200                 205             


Val Asn Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu 
    210                 215                 220                 


Asp Val Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu 
225                 230                 235                 240 


His Ala Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile 
                245                 250                 255     


Ser Pro Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly 
            260                 265                 270         


Arg Phe Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys 
        275                 280                 285             


Pro Asn Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala 
    290                 295                 300                 


Gln Arg Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu 
305                 310                 315                 320 


Pro Asn Met Thr Gln Gly Phe Trp Glu Asn Ser Met Leu Thr Asp Pro 
                325                 330                 335     


Gly Asn Val Gln Lys Ala Val Cys His Pro Thr Ala Trp Asp Leu Gly 
            340                 345                 350         


Lys Gly Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp 
        355                 360                 365             


Phe Leu Thr Ala His His Glu Met Gly His Ile Gln Tyr Asp Met Ala 
    370                 375                 380                 


Tyr Ala Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe 
385                 390                 395                 400 


His Glu Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys 
                405                 410                 415     


His Leu Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn 
            420                 425                 430         


Glu Thr Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly 
        435                 440                 445             


Thr Leu Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe 
    450                 455                 460                 


Lys Gly Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met 
465                 470                 475                 480 


Lys Arg Glu Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr 
                485                 490                 495     


Tyr Cys Asp Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe 
            500                 505                 510         


Ile Arg Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala 
        515                 520                 525             


Leu Cys Gln Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile 
    530                 535                 540                 


Ser Asn Ser Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu 
545                 550                 555                 560 


Gly Lys Ser Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala 
                565                 570                 575     


Lys Asn Met Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe 
            580                 585                 590         


Thr Trp Leu Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr 
        595                 600                 605             


Asp Trp Ser Pro Tyr Ala Asp Gln Ser Ile Lys Val Arg Ile Ser Leu 
    610                 615                 620                 


Lys Ser Ala Leu Gly Asp Lys Ala Tyr Glu Trp Asn Asp Asn Glu Met 
625                 630                 635                 640 


Tyr Leu Phe Arg Ser Ser Val Ala Tyr Ala Met Arg Gln Tyr Phe Leu 
                645                 650                 655     


Lys Val Lys Asn Gln Met Ile Leu Phe Gly Glu Glu Asp Val Arg Val 
            660                 665                 670         


Ala Asn Leu Lys Pro Arg Ile Ser Phe Asn Phe Phe Val Thr Ala Pro 
        675                 680                 685             


Lys Asn Val Ser Asp Ile Ile Pro Arg Thr Glu Val Glu Lys Ala Ile 
    690                 695                 700                 


Arg Met Ser Arg Ser Arg Ile Asn Asp Ala Phe Arg Leu Asn Asp Asn 
705                 710                 715                 720 


Ser Leu Glu Phe Leu Gly Ile Gln Pro Thr Leu Gly Pro Pro Asn Gln 
                725                 730                 735     


Pro Pro Val Ser Ile Trp Leu Ile Val Phe Gly Val Val Met Gly Val 
            740                 745                 750         


Ile Val Val Gly Ile Val Ile Leu Ile Phe Thr Gly Ile Arg Asp Arg 
        755                 760                 765             


Lys Lys Lys Asn Lys Ala Arg Ser Gly Glu Asn Pro Tyr Ala Ser Ile 
    770                 775                 780                 


Asp Ile Ser Lys Gly Glu Asn Asn Pro Gly Phe Gln Asn Thr Asp Asp 
785                 790                 795                 800 


Val Gln Thr Ser Phe 
                805 


<210>  137
<211>  805
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  T27 mutant ACE2


<220>
<221>  MUTAGEN
<222>  (27)..(27)
<223>  The sequence here can be Ala, Arg, Asn, Asp, Cys, Gln, Glu, Gly, 
       His, Ile, Lys, Leu, Met, Phe, Pro, Ser, Trp, Tyr, or Val.

<400>  137

Met Ser Ser Ser Ser Trp Leu Leu Leu Ser Leu Val Ala Val Thr Ala 
1               5                   10                  15      


Ala Gln Ser Thr Ile Glu Glu Gln Ala Lys Xaa Phe Leu Asp Lys Phe 
            20                  25                  30          


Asn His Glu Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ser Trp 
        35                  40                  45              


Asn Tyr Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn 
    50                  55                  60                  


Ala Gly Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Leu Ala 
65                  70                  75                  80  


Gln Met Tyr Pro Leu Gln Glu Ile Gln Asn Leu Thr Val Lys Leu Gln 
                85                  90                  95      


Leu Gln Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys 
            100                 105                 110         


Ser Lys Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser 
        115                 120                 125             


Thr Gly Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu 
    130                 135                 140                 


Glu Pro Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu 
145                 150                 155                 160 


Arg Leu Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu 
                165                 170                 175     


Arg Pro Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg 
            180                 185                 190         


Ala Asn His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu 
        195                 200                 205             


Val Asn Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu 
    210                 215                 220                 


Asp Val Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu 
225                 230                 235                 240 


His Ala Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile 
                245                 250                 255     


Ser Pro Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly 
            260                 265                 270         


Arg Phe Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys 
        275                 280                 285             


Pro Asn Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala 
    290                 295                 300                 


Gln Arg Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu 
305                 310                 315                 320 


Pro Asn Met Thr Gln Gly Phe Trp Glu Asn Ser Met Leu Thr Asp Pro 
                325                 330                 335     


Gly Asn Val Gln Lys Ala Val Cys His Pro Thr Ala Trp Asp Leu Gly 
            340                 345                 350         


Lys Gly Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp 
        355                 360                 365             


Phe Leu Thr Ala His His Glu Met Gly His Ile Gln Tyr Asp Met Ala 
    370                 375                 380                 


Tyr Ala Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe 
385                 390                 395                 400 


His Glu Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys 
                405                 410                 415     


His Leu Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn 
            420                 425                 430         


Glu Thr Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly 
        435                 440                 445             


Thr Leu Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe 
    450                 455                 460                 


Lys Gly Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met 
465                 470                 475                 480 


Lys Arg Glu Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr 
                485                 490                 495     


Tyr Cys Asp Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe 
            500                 505                 510         


Ile Arg Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala 
        515                 520                 525             


Leu Cys Gln Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile 
    530                 535                 540                 


Ser Asn Ser Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu 
545                 550                 555                 560 


Gly Lys Ser Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala 
                565                 570                 575     


Lys Asn Met Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe 
            580                 585                 590         


Thr Trp Leu Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr 
        595                 600                 605             


Asp Trp Ser Pro Tyr Ala Asp Gln Ser Ile Lys Val Arg Ile Ser Leu 
    610                 615                 620                 


Lys Ser Ala Leu Gly Asp Lys Ala Tyr Glu Trp Asn Asp Asn Glu Met 
625                 630                 635                 640 


Tyr Leu Phe Arg Ser Ser Val Ala Tyr Ala Met Arg Gln Tyr Phe Leu 
                645                 650                 655     


Lys Val Lys Asn Gln Met Ile Leu Phe Gly Glu Glu Asp Val Arg Val 
            660                 665                 670         


Ala Asn Leu Lys Pro Arg Ile Ser Phe Asn Phe Phe Val Thr Ala Pro 
        675                 680                 685             


Lys Asn Val Ser Asp Ile Ile Pro Arg Thr Glu Val Glu Lys Ala Ile 
    690                 695                 700                 


Arg Met Ser Arg Ser Arg Ile Asn Asp Ala Phe Arg Leu Asn Asp Asn 
705                 710                 715                 720 


Ser Leu Glu Phe Leu Gly Ile Gln Pro Thr Leu Gly Pro Pro Asn Gln 
                725                 730                 735     


Pro Pro Val Ser Ile Trp Leu Ile Val Phe Gly Val Val Met Gly Val 
            740                 745                 750         


Ile Val Val Gly Ile Val Ile Leu Ile Phe Thr Gly Ile Arg Asp Arg 
        755                 760                 765             


Lys Lys Lys Asn Lys Ala Arg Ser Gly Glu Asn Pro Tyr Ala Ser Ile 
    770                 775                 780                 


Asp Ile Ser Lys Gly Glu Asn Asn Pro Gly Phe Gln Asn Thr Asp Asp 
785                 790                 795                 800 


Val Gln Thr Ser Phe 
                805 


<210>  138
<211>  805
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  D30 mutant ACE2


<220>
<221>  MUTAGEN
<222>  (30)..(30)
<223>  The sequence here can be Ala, Arg, Asn, Cys, Gln, Glu, Gly, His, 
       Ile, Lys, Leu, Met, Phe, Pro, Ser, Thr, Trp, Tyr, or Val.

<400>  138

Met Ser Ser Ser Ser Trp Leu Leu Leu Ser Leu Val Ala Val Thr Ala 
1               5                   10                  15      


Ala Gln Ser Thr Ile Glu Glu Gln Ala Lys Thr Phe Leu Xaa Lys Phe 
            20                  25                  30          


Asn His Glu Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ser Trp 
        35                  40                  45              


Asn Tyr Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn 
    50                  55                  60                  


Ala Gly Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Leu Ala 
65                  70                  75                  80  


Gln Met Tyr Pro Leu Gln Glu Ile Gln Asn Leu Thr Val Lys Leu Gln 
                85                  90                  95      


Leu Gln Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys 
            100                 105                 110         


Ser Lys Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser 
        115                 120                 125             


Thr Gly Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu 
    130                 135                 140                 


Glu Pro Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu 
145                 150                 155                 160 


Arg Leu Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu 
                165                 170                 175     


Arg Pro Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg 
            180                 185                 190         


Ala Asn His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu 
        195                 200                 205             


Val Asn Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu 
    210                 215                 220                 


Asp Val Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu 
225                 230                 235                 240 


His Ala Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile 
                245                 250                 255     


Ser Pro Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly 
            260                 265                 270         


Arg Phe Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys 
        275                 280                 285             


Pro Asn Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala 
    290                 295                 300                 


Gln Arg Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu 
305                 310                 315                 320 


Pro Asn Met Thr Gln Gly Phe Trp Glu Asn Ser Met Leu Thr Asp Pro 
                325                 330                 335     


Gly Asn Val Gln Lys Ala Val Cys His Pro Thr Ala Trp Asp Leu Gly 
            340                 345                 350         


Lys Gly Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp 
        355                 360                 365             


Phe Leu Thr Ala His His Glu Met Gly His Ile Gln Tyr Asp Met Ala 
    370                 375                 380                 


Tyr Ala Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe 
385                 390                 395                 400 


His Glu Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys 
                405                 410                 415     


His Leu Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn 
            420                 425                 430         


Glu Thr Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly 
        435                 440                 445             


Thr Leu Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe 
    450                 455                 460                 


Lys Gly Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met 
465                 470                 475                 480 


Lys Arg Glu Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr 
                485                 490                 495     


Tyr Cys Asp Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe 
            500                 505                 510         


Ile Arg Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala 
        515                 520                 525             


Leu Cys Gln Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile 
    530                 535                 540                 


Ser Asn Ser Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu 
545                 550                 555                 560 


Gly Lys Ser Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala 
                565                 570                 575     


Lys Asn Met Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe 
            580                 585                 590         


Thr Trp Leu Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr 
        595                 600                 605             


Asp Trp Ser Pro Tyr Ala Asp Gln Ser Ile Lys Val Arg Ile Ser Leu 
    610                 615                 620                 


Lys Ser Ala Leu Gly Asp Lys Ala Tyr Glu Trp Asn Asp Asn Glu Met 
625                 630                 635                 640 


Tyr Leu Phe Arg Ser Ser Val Ala Tyr Ala Met Arg Gln Tyr Phe Leu 
                645                 650                 655     


Lys Val Lys Asn Gln Met Ile Leu Phe Gly Glu Glu Asp Val Arg Val 
            660                 665                 670         


Ala Asn Leu Lys Pro Arg Ile Ser Phe Asn Phe Phe Val Thr Ala Pro 
        675                 680                 685             


Lys Asn Val Ser Asp Ile Ile Pro Arg Thr Glu Val Glu Lys Ala Ile 
    690                 695                 700                 


Arg Met Ser Arg Ser Arg Ile Asn Asp Ala Phe Arg Leu Asn Asp Asn 
705                 710                 715                 720 


Ser Leu Glu Phe Leu Gly Ile Gln Pro Thr Leu Gly Pro Pro Asn Gln 
                725                 730                 735     


Pro Pro Val Ser Ile Trp Leu Ile Val Phe Gly Val Val Met Gly Val 
            740                 745                 750         


Ile Val Val Gly Ile Val Ile Leu Ile Phe Thr Gly Ile Arg Asp Arg 
        755                 760                 765             


Lys Lys Lys Asn Lys Ala Arg Ser Gly Glu Asn Pro Tyr Ala Ser Ile 
    770                 775                 780                 


Asp Ile Ser Lys Gly Glu Asn Asn Pro Gly Phe Gln Asn Thr Asp Asp 
785                 790                 795                 800 


Val Gln Thr Ser Phe 
                805 


<210>  139
<211>  805
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H34 mutant ACE2


<220>
<221>  MUTAGEN
<222>  (34)..(34)
<223>  The sequence here can be Ala, Arg, Asn, Asp, Cys, Gln, Glu, Gly, 
       Ile, Lys, Leu, Met, Phe, Pro, Ser, Thr, Trp, Tyr, or Val.

<400>  139

Met Ser Ser Ser Ser Trp Leu Leu Leu Ser Leu Val Ala Val Thr Ala 
1               5                   10                  15      


Ala Gln Ser Thr Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Lys Phe 
            20                  25                  30          


Asn Xaa Glu Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ser Trp 
        35                  40                  45              


Asn Tyr Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn 
    50                  55                  60                  


Ala Gly Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Leu Ala 
65                  70                  75                  80  


Gln Met Tyr Pro Leu Gln Glu Ile Gln Asn Leu Thr Val Lys Leu Gln 
                85                  90                  95      


Leu Gln Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys 
            100                 105                 110         


Ser Lys Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser 
        115                 120                 125             


Thr Gly Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu 
    130                 135                 140                 


Glu Pro Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu 
145                 150                 155                 160 


Arg Leu Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu 
                165                 170                 175     


Arg Pro Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg 
            180                 185                 190         


Ala Asn His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu 
        195                 200                 205             


Val Asn Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu 
    210                 215                 220                 


Asp Val Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu 
225                 230                 235                 240 


His Ala Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile 
                245                 250                 255     


Ser Pro Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly 
            260                 265                 270         


Arg Phe Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys 
        275                 280                 285             


Pro Asn Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala 
    290                 295                 300                 


Gln Arg Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu 
305                 310                 315                 320 


Pro Asn Met Thr Gln Gly Phe Trp Glu Asn Ser Met Leu Thr Asp Pro 
                325                 330                 335     


Gly Asn Val Gln Lys Ala Val Cys His Pro Thr Ala Trp Asp Leu Gly 
            340                 345                 350         


Lys Gly Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp 
        355                 360                 365             


Phe Leu Thr Ala His His Glu Met Gly His Ile Gln Tyr Asp Met Ala 
    370                 375                 380                 


Tyr Ala Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe 
385                 390                 395                 400 


His Glu Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys 
                405                 410                 415     


His Leu Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn 
            420                 425                 430         


Glu Thr Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly 
        435                 440                 445             


Thr Leu Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe 
    450                 455                 460                 


Lys Gly Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met 
465                 470                 475                 480 


Lys Arg Glu Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr 
                485                 490                 495     


Tyr Cys Asp Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe 
            500                 505                 510         


Ile Arg Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala 
        515                 520                 525             


Leu Cys Gln Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile 
    530                 535                 540                 


Ser Asn Ser Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu 
545                 550                 555                 560 


Gly Lys Ser Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala 
                565                 570                 575     


Lys Asn Met Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe 
            580                 585                 590         


Thr Trp Leu Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr 
        595                 600                 605             


Asp Trp Ser Pro Tyr Ala Asp Gln Ser Ile Lys Val Arg Ile Ser Leu 
    610                 615                 620                 


Lys Ser Ala Leu Gly Asp Lys Ala Tyr Glu Trp Asn Asp Asn Glu Met 
625                 630                 635                 640 


Tyr Leu Phe Arg Ser Ser Val Ala Tyr Ala Met Arg Gln Tyr Phe Leu 
                645                 650                 655     


Lys Val Lys Asn Gln Met Ile Leu Phe Gly Glu Glu Asp Val Arg Val 
            660                 665                 670         


Ala Asn Leu Lys Pro Arg Ile Ser Phe Asn Phe Phe Val Thr Ala Pro 
        675                 680                 685             


Lys Asn Val Ser Asp Ile Ile Pro Arg Thr Glu Val Glu Lys Ala Ile 
    690                 695                 700                 


Arg Met Ser Arg Ser Arg Ile Asn Asp Ala Phe Arg Leu Asn Asp Asn 
705                 710                 715                 720 


Ser Leu Glu Phe Leu Gly Ile Gln Pro Thr Leu Gly Pro Pro Asn Gln 
                725                 730                 735     


Pro Pro Val Ser Ile Trp Leu Ile Val Phe Gly Val Val Met Gly Val 
            740                 745                 750         


Ile Val Val Gly Ile Val Ile Leu Ile Phe Thr Gly Ile Arg Asp Arg 
        755                 760                 765             


Lys Lys Lys Asn Lys Ala Arg Ser Gly Glu Asn Pro Tyr Ala Ser Ile 
    770                 775                 780                 


Asp Ile Ser Lys Gly Glu Asn Asn Pro Gly Phe Gln Asn Thr Asp Asp 
785                 790                 795                 800 


Val Gln Thr Ser Phe 
                805 


<210>  140
<211>  805
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  E35 mutant ACE2


<220>
<221>  MUTAGEN
<222>  (35)..(35)
<223>  The sequence here can be Ala, Arg, Asn, Asp, Cys, Gln, Gly, His, 
       Ile, Lys, Leu, Met, Phe, Pro, Ser, Thr, Trp, Tyr, or Val.

<400>  140

Met Ser Ser Ser Ser Trp Leu Leu Leu Ser Leu Val Ala Val Thr Ala 
1               5                   10                  15      


Ala Gln Ser Thr Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Lys Phe 
            20                  25                  30          


Asn His Xaa Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ser Trp 
        35                  40                  45              


Asn Tyr Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn 
    50                  55                  60                  


Ala Gly Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Leu Ala 
65                  70                  75                  80  


Gln Met Tyr Pro Leu Gln Glu Ile Gln Asn Leu Thr Val Lys Leu Gln 
                85                  90                  95      


Leu Gln Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys 
            100                 105                 110         


Ser Lys Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser 
        115                 120                 125             


Thr Gly Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu 
    130                 135                 140                 


Glu Pro Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu 
145                 150                 155                 160 


Arg Leu Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu 
                165                 170                 175     


Arg Pro Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg 
            180                 185                 190         


Ala Asn His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu 
        195                 200                 205             


Val Asn Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu 
    210                 215                 220                 


Asp Val Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu 
225                 230                 235                 240 


His Ala Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile 
                245                 250                 255     


Ser Pro Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly 
            260                 265                 270         


Arg Phe Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys 
        275                 280                 285             


Pro Asn Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala 
    290                 295                 300                 


Gln Arg Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu 
305                 310                 315                 320 


Pro Asn Met Thr Gln Gly Phe Trp Glu Asn Ser Met Leu Thr Asp Pro 
                325                 330                 335     


Gly Asn Val Gln Lys Ala Val Cys His Pro Thr Ala Trp Asp Leu Gly 
            340                 345                 350         


Lys Gly Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp 
        355                 360                 365             


Phe Leu Thr Ala His His Glu Met Gly His Ile Gln Tyr Asp Met Ala 
    370                 375                 380                 


Tyr Ala Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe 
385                 390                 395                 400 


His Glu Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys 
                405                 410                 415     


His Leu Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn 
            420                 425                 430         


Glu Thr Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly 
        435                 440                 445             


Thr Leu Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe 
    450                 455                 460                 


Lys Gly Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met 
465                 470                 475                 480 


Lys Arg Glu Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr 
                485                 490                 495     


Tyr Cys Asp Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe 
            500                 505                 510         


Ile Arg Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala 
        515                 520                 525             


Leu Cys Gln Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile 
    530                 535                 540                 


Ser Asn Ser Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu 
545                 550                 555                 560 


Gly Lys Ser Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala 
                565                 570                 575     


Lys Asn Met Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe 
            580                 585                 590         


Thr Trp Leu Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr 
        595                 600                 605             


Asp Trp Ser Pro Tyr Ala Asp Gln Ser Ile Lys Val Arg Ile Ser Leu 
    610                 615                 620                 


Lys Ser Ala Leu Gly Asp Lys Ala Tyr Glu Trp Asn Asp Asn Glu Met 
625                 630                 635                 640 


Tyr Leu Phe Arg Ser Ser Val Ala Tyr Ala Met Arg Gln Tyr Phe Leu 
                645                 650                 655     


Lys Val Lys Asn Gln Met Ile Leu Phe Gly Glu Glu Asp Val Arg Val 
            660                 665                 670         


Ala Asn Leu Lys Pro Arg Ile Ser Phe Asn Phe Phe Val Thr Ala Pro 
        675                 680                 685             


Lys Asn Val Ser Asp Ile Ile Pro Arg Thr Glu Val Glu Lys Ala Ile 
    690                 695                 700                 


Arg Met Ser Arg Ser Arg Ile Asn Asp Ala Phe Arg Leu Asn Asp Asn 
705                 710                 715                 720 


Ser Leu Glu Phe Leu Gly Ile Gln Pro Thr Leu Gly Pro Pro Asn Gln 
                725                 730                 735     


Pro Pro Val Ser Ile Trp Leu Ile Val Phe Gly Val Val Met Gly Val 
            740                 745                 750         


Ile Val Val Gly Ile Val Ile Leu Ile Phe Thr Gly Ile Arg Asp Arg 
        755                 760                 765             


Lys Lys Lys Asn Lys Ala Arg Ser Gly Glu Asn Pro Tyr Ala Ser Ile 
    770                 775                 780                 


Asp Ile Ser Lys Gly Glu Asn Asn Pro Gly Phe Gln Asn Thr Asp Asp 
785                 790                 795                 800 


Val Gln Thr Ser Phe 
                805 


<210>  141
<211>  805
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  D38 mutant ACE2


<220>
<221>  MUTAGEN
<222>  (38)..(38)
<223>  The sequence here can be Ala, Arg, Asn, Cys, Gln, Glu, Gly, His, 
       Ile, Lys, Leu, Met, Phe, Pro, Ser, Thr, Trp, Tyr, or Val.

<400>  141

Met Ser Ser Ser Ser Trp Leu Leu Leu Ser Leu Val Ala Val Thr Ala 
1               5                   10                  15      


Ala Gln Ser Thr Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Lys Phe 
            20                  25                  30          


Asn His Glu Ala Glu Xaa Leu Phe Tyr Gln Ser Ser Leu Ala Ser Trp 
        35                  40                  45              


Asn Tyr Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn 
    50                  55                  60                  


Ala Gly Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Leu Ala 
65                  70                  75                  80  


Gln Met Tyr Pro Leu Gln Glu Ile Gln Asn Leu Thr Val Lys Leu Gln 
                85                  90                  95      


Leu Gln Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys 
            100                 105                 110         


Ser Lys Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser 
        115                 120                 125             


Thr Gly Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu 
    130                 135                 140                 


Glu Pro Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu 
145                 150                 155                 160 


Arg Leu Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu 
                165                 170                 175     


Arg Pro Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg 
            180                 185                 190         


Ala Asn His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu 
        195                 200                 205             


Val Asn Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu 
    210                 215                 220                 


Asp Val Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu 
225                 230                 235                 240 


His Ala Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile 
                245                 250                 255     


Ser Pro Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly 
            260                 265                 270         


Arg Phe Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys 
        275                 280                 285             


Pro Asn Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala 
    290                 295                 300                 


Gln Arg Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu 
305                 310                 315                 320 


Pro Asn Met Thr Gln Gly Phe Trp Glu Asn Ser Met Leu Thr Asp Pro 
                325                 330                 335     


Gly Asn Val Gln Lys Ala Val Cys His Pro Thr Ala Trp Asp Leu Gly 
            340                 345                 350         


Lys Gly Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp 
        355                 360                 365             


Phe Leu Thr Ala His His Glu Met Gly His Ile Gln Tyr Asp Met Ala 
    370                 375                 380                 


Tyr Ala Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe 
385                 390                 395                 400 


His Glu Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys 
                405                 410                 415     


His Leu Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn 
            420                 425                 430         


Glu Thr Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly 
        435                 440                 445             


Thr Leu Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe 
    450                 455                 460                 


Lys Gly Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met 
465                 470                 475                 480 


Lys Arg Glu Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr 
                485                 490                 495     


Tyr Cys Asp Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe 
            500                 505                 510         


Ile Arg Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala 
        515                 520                 525             


Leu Cys Gln Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile 
    530                 535                 540                 


Ser Asn Ser Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu 
545                 550                 555                 560 


Gly Lys Ser Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala 
                565                 570                 575     


Lys Asn Met Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe 
            580                 585                 590         


Thr Trp Leu Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr 
        595                 600                 605             


Asp Trp Ser Pro Tyr Ala Asp Gln Ser Ile Lys Val Arg Ile Ser Leu 
    610                 615                 620                 


Lys Ser Ala Leu Gly Asp Lys Ala Tyr Glu Trp Asn Asp Asn Glu Met 
625                 630                 635                 640 


Tyr Leu Phe Arg Ser Ser Val Ala Tyr Ala Met Arg Gln Tyr Phe Leu 
                645                 650                 655     


Lys Val Lys Asn Gln Met Ile Leu Phe Gly Glu Glu Asp Val Arg Val 
            660                 665                 670         


Ala Asn Leu Lys Pro Arg Ile Ser Phe Asn Phe Phe Val Thr Ala Pro 
        675                 680                 685             


Lys Asn Val Ser Asp Ile Ile Pro Arg Thr Glu Val Glu Lys Ala Ile 
    690                 695                 700                 


Arg Met Ser Arg Ser Arg Ile Asn Asp Ala Phe Arg Leu Asn Asp Asn 
705                 710                 715                 720 


Ser Leu Glu Phe Leu Gly Ile Gln Pro Thr Leu Gly Pro Pro Asn Gln 
                725                 730                 735     


Pro Pro Val Ser Ile Trp Leu Ile Val Phe Gly Val Val Met Gly Val 
            740                 745                 750         


Ile Val Val Gly Ile Val Ile Leu Ile Phe Thr Gly Ile Arg Asp Arg 
        755                 760                 765             


Lys Lys Lys Asn Lys Ala Arg Ser Gly Glu Asn Pro Tyr Ala Ser Ile 
    770                 775                 780                 


Asp Ile Ser Lys Gly Glu Asn Asn Pro Gly Phe Gln Asn Thr Asp Asp 
785                 790                 795                 800 


Val Gln Thr Ser Phe 
                805 


<210>  142
<211>  805
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Y41 mutant ACE2


<220>
<221>  MUTAGEN
<222>  (41)..(41)
<223>  The sequence here can be Ala, Arg, Asn, Asp, Cys, Gln, Glu, Gly, 
       His, Ile, Lys, Leu, Met, Phe, Pro, Ser, Thr, Trp, or Val.

<400>  142

Met Ser Ser Ser Ser Trp Leu Leu Leu Ser Leu Val Ala Val Thr Ala 
1               5                   10                  15      


Ala Gln Ser Thr Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Lys Phe 
            20                  25                  30          


Asn His Glu Ala Glu Asp Leu Phe Xaa Gln Ser Ser Leu Ala Ser Trp 
        35                  40                  45              


Asn Tyr Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn 
    50                  55                  60                  


Ala Gly Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Leu Ala 
65                  70                  75                  80  


Gln Met Tyr Pro Leu Gln Glu Ile Gln Asn Leu Thr Val Lys Leu Gln 
                85                  90                  95      


Leu Gln Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys 
            100                 105                 110         


Ser Lys Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser 
        115                 120                 125             


Thr Gly Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu 
    130                 135                 140                 


Glu Pro Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu 
145                 150                 155                 160 


Arg Leu Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu 
                165                 170                 175     


Arg Pro Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg 
            180                 185                 190         


Ala Asn His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu 
        195                 200                 205             


Val Asn Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu 
    210                 215                 220                 


Asp Val Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu 
225                 230                 235                 240 


His Ala Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile 
                245                 250                 255     


Ser Pro Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly 
            260                 265                 270         


Arg Phe Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys 
        275                 280                 285             


Pro Asn Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala 
    290                 295                 300                 


Gln Arg Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu 
305                 310                 315                 320 


Pro Asn Met Thr Gln Gly Phe Trp Glu Asn Ser Met Leu Thr Asp Pro 
                325                 330                 335     


Gly Asn Val Gln Lys Ala Val Cys His Pro Thr Ala Trp Asp Leu Gly 
            340                 345                 350         


Lys Gly Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp 
        355                 360                 365             


Phe Leu Thr Ala His His Glu Met Gly His Ile Gln Tyr Asp Met Ala 
    370                 375                 380                 


Tyr Ala Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe 
385                 390                 395                 400 


His Glu Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys 
                405                 410                 415     


His Leu Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn 
            420                 425                 430         


Glu Thr Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly 
        435                 440                 445             


Thr Leu Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe 
    450                 455                 460                 


Lys Gly Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met 
465                 470                 475                 480 


Lys Arg Glu Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr 
                485                 490                 495     


Tyr Cys Asp Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe 
            500                 505                 510         


Ile Arg Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala 
        515                 520                 525             


Leu Cys Gln Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile 
    530                 535                 540                 


Ser Asn Ser Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu 
545                 550                 555                 560 


Gly Lys Ser Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala 
                565                 570                 575     


Lys Asn Met Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe 
            580                 585                 590         


Thr Trp Leu Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr 
        595                 600                 605             


Asp Trp Ser Pro Tyr Ala Asp Gln Ser Ile Lys Val Arg Ile Ser Leu 
    610                 615                 620                 


Lys Ser Ala Leu Gly Asp Lys Ala Tyr Glu Trp Asn Asp Asn Glu Met 
625                 630                 635                 640 


Tyr Leu Phe Arg Ser Ser Val Ala Tyr Ala Met Arg Gln Tyr Phe Leu 
                645                 650                 655     


Lys Val Lys Asn Gln Met Ile Leu Phe Gly Glu Glu Asp Val Arg Val 
            660                 665                 670         


Ala Asn Leu Lys Pro Arg Ile Ser Phe Asn Phe Phe Val Thr Ala Pro 
        675                 680                 685             


Lys Asn Val Ser Asp Ile Ile Pro Arg Thr Glu Val Glu Lys Ala Ile 
    690                 695                 700                 


Arg Met Ser Arg Ser Arg Ile Asn Asp Ala Phe Arg Leu Asn Asp Asn 
705                 710                 715                 720 


Ser Leu Glu Phe Leu Gly Ile Gln Pro Thr Leu Gly Pro Pro Asn Gln 
                725                 730                 735     


Pro Pro Val Ser Ile Trp Leu Ile Val Phe Gly Val Val Met Gly Val 
            740                 745                 750         


Ile Val Val Gly Ile Val Ile Leu Ile Phe Thr Gly Ile Arg Asp Arg 
        755                 760                 765             


Lys Lys Lys Asn Lys Ala Arg Ser Gly Glu Asn Pro Tyr Ala Ser Ile 
    770                 775                 780                 


Asp Ile Ser Lys Gly Glu Asn Asn Pro Gly Phe Gln Asn Thr Asp Asp 
785                 790                 795                 800 


Val Gln Thr Ser Phe 
                805 


<210>  143
<211>  805
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  D355 mutant ACE2


<220>
<221>  MUTAGEN
<222>  (355)..(355)
<223>  The sequence here can be Ala, Arg, Asn, Cys, Gln, Glu, Gly, His, 
       Ile, Lys, Leu, Met, Phe, Pro, Ser, Thr, Trp, Tyr, or Val.

<400>  143

Met Ser Ser Ser Ser Trp Leu Leu Leu Ser Leu Val Ala Val Thr Ala 
1               5                   10                  15      


Ala Gln Ser Thr Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Lys Phe 
            20                  25                  30          


Asn His Glu Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ser Trp 
        35                  40                  45              


Asn Tyr Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn 
    50                  55                  60                  


Ala Gly Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Leu Ala 
65                  70                  75                  80  


Gln Met Tyr Pro Leu Gln Glu Ile Gln Asn Leu Thr Val Lys Leu Gln 
                85                  90                  95      


Leu Gln Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys 
            100                 105                 110         


Ser Lys Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser 
        115                 120                 125             


Thr Gly Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu 
    130                 135                 140                 


Glu Pro Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu 
145                 150                 155                 160 


Arg Leu Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu 
                165                 170                 175     


Arg Pro Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg 
            180                 185                 190         


Ala Asn His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu 
        195                 200                 205             


Val Asn Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu 
    210                 215                 220                 


Asp Val Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu 
225                 230                 235                 240 


His Ala Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile 
                245                 250                 255     


Ser Pro Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly 
            260                 265                 270         


Arg Phe Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys 
        275                 280                 285             


Pro Asn Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala 
    290                 295                 300                 


Gln Arg Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu 
305                 310                 315                 320 


Pro Asn Met Thr Gln Gly Phe Trp Glu Asn Ser Met Leu Thr Asp Pro 
                325                 330                 335     


Gly Asn Val Gln Lys Ala Val Cys His Pro Thr Ala Trp Asp Leu Gly 
            340                 345                 350         


Lys Gly Xaa Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp 
        355                 360                 365             


Phe Leu Thr Ala His His Glu Met Gly His Ile Gln Tyr Asp Met Ala 
    370                 375                 380                 


Tyr Ala Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe 
385                 390                 395                 400 


His Glu Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys 
                405                 410                 415     


His Leu Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn 
            420                 425                 430         


Glu Thr Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly 
        435                 440                 445             


Thr Leu Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe 
    450                 455                 460                 


Lys Gly Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met 
465                 470                 475                 480 


Lys Arg Glu Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr 
                485                 490                 495     


Tyr Cys Asp Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe 
            500                 505                 510         


Ile Arg Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala 
        515                 520                 525             


Leu Cys Gln Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile 
    530                 535                 540                 


Ser Asn Ser Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu 
545                 550                 555                 560 


Gly Lys Ser Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala 
                565                 570                 575     


Lys Asn Met Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe 
            580                 585                 590         


Thr Trp Leu Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr 
        595                 600                 605             


Asp Trp Ser Pro Tyr Ala Asp Gln Ser Ile Lys Val Arg Ile Ser Leu 
    610                 615                 620                 


Lys Ser Ala Leu Gly Asp Lys Ala Tyr Glu Trp Asn Asp Asn Glu Met 
625                 630                 635                 640 


Tyr Leu Phe Arg Ser Ser Val Ala Tyr Ala Met Arg Gln Tyr Phe Leu 
                645                 650                 655     


Lys Val Lys Asn Gln Met Ile Leu Phe Gly Glu Glu Asp Val Arg Val 
            660                 665                 670         


Ala Asn Leu Lys Pro Arg Ile Ser Phe Asn Phe Phe Val Thr Ala Pro 
        675                 680                 685             


Lys Asn Val Ser Asp Ile Ile Pro Arg Thr Glu Val Glu Lys Ala Ile 
    690                 695                 700                 


Arg Met Ser Arg Ser Arg Ile Asn Asp Ala Phe Arg Leu Asn Asp Asn 
705                 710                 715                 720 


Ser Leu Glu Phe Leu Gly Ile Gln Pro Thr Leu Gly Pro Pro Asn Gln 
                725                 730                 735     


Pro Pro Val Ser Ile Trp Leu Ile Val Phe Gly Val Val Met Gly Val 
            740                 745                 750         


Ile Val Val Gly Ile Val Ile Leu Ile Phe Thr Gly Ile Arg Asp Arg 
        755                 760                 765             


Lys Lys Lys Asn Lys Ala Arg Ser Gly Glu Asn Pro Tyr Ala Ser Ile 
    770                 775                 780                 


Asp Ile Ser Lys Gly Glu Asn Asn Pro Gly Phe Gln Asn Thr Asp Asp 
785                 790                 795                 800 


Val Gln Thr Ser Phe 
                805 


<210>  144
<211>  805
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutant ACE2


<220>
<221>  MUTAGEN
<222>  (24)..(24)
<223>  The sequence here can be Ala, Arg, Asn, Asp, Cys, Glu, Gly, His, 
       Ile, Lys, Leu, Met, Phe, Pro, Ser, Thr, Trp, Tyr, or Val.

<220>
<221>  MUTAGEN
<222>  (27)..(27)
<223>  The sequence here can be Ala, Arg, Asn, Asp, Cys, Gln, Glu, Gly, 
       His, Ile, Lys, Leu, Met, Phe, Pro, Ser, Trp, Tyr, or Val.

<220>
<221>  MUTAGEN
<222>  (30)..(30)
<223>  The sequence here can be Ala, Arg, Asn, Cys, Gln, Glu, Gly, His, 
       Ile, Lys, Leu, Met, Phe, Pro, Ser, Thr, Trp, Tyr, or Val.

<220>
<221>  MUTAGEN
<222>  (34)..(34)
<223>  The sequence here can be Ala, Arg, Asn, Asp, Cys, Gln, Glu, Gly, 
       Ile, Lys, Leu, Met, Phe, Pro, Ser, Thr, Trp, Tyr, or Val.

<220>
<221>  MUTAGEN
<222>  (35)..(35)
<223>  The sequence here can be Ala, Arg, Asn, Asp, Cys, Gln, Gly, His, 
       Ile, Lys, Leu, Met, Phe, Pro, Ser, Thr, Trp, Tyr, or Val.

<220>
<221>  MUTAGEN
<222>  (38)..(38)
<223>  The sequence here can be Ala, Arg, Asn, Cys, Gln, Glu, Gly, His, 
       Ile, Lys, Leu, Met, Phe, Pro, Ser, Thr, Trp, Tyr, or Val.

<220>
<221>  MUTAGEN
<222>  (41)..(41)
<223>  The sequence here can be Ala, Arg, Asn, Asp, Cys, Gln, Glu, Gly, 
       His, Ile, Lys, Leu, Met, Phe, Pro, Ser, Thr, Trp, or Val.

<220>
<221>  MUTAGEN
<222>  (273)..(273)
<223>  The sequence here can be Ala, Asn, Asp, Cys, Gln, Glu, Gly, His, 
       Ile, Lys, Leu, Met, Phe, Pro, Ser, Thr, Trp, Tyr, or Val.

<220>
<221>  MUTAGEN
<222>  (345)..(345)
<223>  The sequence here can be Ala, Arg, Asn, Asp, Cys, Gln, Glu, Gly, 
       Ile, Lys, Leu, Met, Phe, Pro, Ser, Thr, Trp, Tyr, or Val.

<220>
<221>  MUTAGEN
<222>  (355)..(355)
<223>  The sequence here can be Ala, Arg, Asn, Cys, Gln, Glu, Gly, His, 
       Ile, Lys, Leu, Met, Phe, Pro, Ser, Thr, Trp, Tyr, or Val.

<220>
<221>  MUTAGEN
<222>  (374)..(374)
<223>  The sequence here can be Ala, Arg, Asn, Asp, Cys, Gln, Glu, Gly, 
       Ile, Lys, Leu, Met, Phe, Pro, Ser, Thr, Trp, Tyr, or Val.

<220>
<221>  MUTAGEN
<222>  (378)..(378)
<223>  The sequence here can be Ala, Arg, Asn, Asp, Cys, Gln, Glu, Gly, 
       Ile, Lys, Leu, Met, Phe, Pro, Ser, Thr, Trp, Tyr, or Val.

<220>
<221>  MUTAGEN
<222>  (505)..(505)
<223>  The sequence here can be Ala, Arg, Asn, Asp, Cys, Gln, Glu, Gly, 
       Ile, Lys, Leu, Met, Phe, Pro, Ser, Thr, Trp, Tyr, or Val.

<400>  144

Met Ser Ser Ser Ser Trp Leu Leu Leu Ser Leu Val Ala Val Thr Ala 
1               5                   10                  15      


Ala Gln Ser Thr Ile Glu Glu Xaa Ala Lys Xaa Phe Leu Xaa Lys Phe 
            20                  25                  30          


Asn Xaa Xaa Ala Glu Xaa Leu Phe Xaa Gln Ser Ser Leu Ala Ser Trp 
        35                  40                  45              


Asn Tyr Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn 
    50                  55                  60                  


Ala Gly Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Leu Ala 
65                  70                  75                  80  


Gln Met Tyr Pro Leu Gln Glu Ile Gln Asn Leu Thr Val Lys Leu Gln 
                85                  90                  95      


Leu Gln Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys 
            100                 105                 110         


Ser Lys Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser 
        115                 120                 125             


Thr Gly Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu 
    130                 135                 140                 


Glu Pro Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu 
145                 150                 155                 160 


Arg Leu Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu 
                165                 170                 175     


Arg Pro Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg 
            180                 185                 190         


Ala Asn His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu 
        195                 200                 205             


Val Asn Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu 
    210                 215                 220                 


Asp Val Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu 
225                 230                 235                 240 


His Ala Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile 
                245                 250                 255     


Ser Pro Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly 
            260                 265                 270         


Xaa Phe Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys 
        275                 280                 285             


Pro Asn Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala 
    290                 295                 300                 


Gln Arg Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu 
305                 310                 315                 320 


Pro Asn Met Thr Gln Gly Phe Trp Glu Asn Ser Met Leu Thr Asp Pro 
                325                 330                 335     


Gly Asn Val Gln Lys Ala Val Cys Xaa Pro Thr Ala Trp Asp Leu Gly 
            340                 345                 350         


Lys Gly Xaa Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp 
        355                 360                 365             


Phe Leu Thr Ala His Xaa Glu Met Gly Xaa Ile Gln Tyr Asp Met Ala 
    370                 375                 380                 


Tyr Ala Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe 
385                 390                 395                 400 


His Glu Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys 
                405                 410                 415     


His Leu Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn 
            420                 425                 430         


Glu Thr Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly 
        435                 440                 445             


Thr Leu Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe 
    450                 455                 460                 


Lys Gly Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met 
465                 470                 475                 480 


Lys Arg Glu Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr 
                485                 490                 495     


Tyr Cys Asp Pro Ala Ser Leu Phe Xaa Val Ser Asn Asp Tyr Ser Phe 
            500                 505                 510         


Ile Arg Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala 
        515                 520                 525             


Leu Cys Gln Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile 
    530                 535                 540                 


Ser Asn Ser Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu 
545                 550                 555                 560 


Gly Lys Ser Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala 
                565                 570                 575     


Lys Asn Met Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe 
            580                 585                 590         


Thr Trp Leu Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr 
        595                 600                 605             


Asp Trp Ser Pro Tyr Ala Asp Gln Ser Ile Lys Val Arg Ile Ser Leu 
    610                 615                 620                 


Lys Ser Ala Leu Gly Asp Lys Ala Tyr Glu Trp Asn Asp Asn Glu Met 
625                 630                 635                 640 


Tyr Leu Phe Arg Ser Ser Val Ala Tyr Ala Met Arg Gln Tyr Phe Leu 
                645                 650                 655     


Lys Val Lys Asn Gln Met Ile Leu Phe Gly Glu Glu Asp Val Arg Val 
            660                 665                 670         


Ala Asn Leu Lys Pro Arg Ile Ser Phe Asn Phe Phe Val Thr Ala Pro 
        675                 680                 685             


Lys Asn Val Ser Asp Ile Ile Pro Arg Thr Glu Val Glu Lys Ala Ile 
    690                 695                 700                 


Arg Met Ser Arg Ser Arg Ile Asn Asp Ala Phe Arg Leu Asn Asp Asn 
705                 710                 715                 720 


Ser Leu Glu Phe Leu Gly Ile Gln Pro Thr Leu Gly Pro Pro Asn Gln 
                725                 730                 735     


Pro Pro Val Ser Ile Trp Leu Ile Val Phe Gly Val Val Met Gly Val 
            740                 745                 750         


Ile Val Val Gly Ile Val Ile Leu Ile Phe Thr Gly Ile Arg Asp Arg 
        755                 760                 765             


Lys Lys Lys Asn Lys Ala Arg Ser Gly Glu Asn Pro Tyr Ala Ser Ile 
    770                 775                 780                 


Asp Ile Ser Lys Gly Glu Asn Asn Pro Gly Phe Gln Asn Thr Asp Asp 
785                 790                 795                 800 


Val Gln Thr Ser Phe 
                805 


<210>  145
<211>  225
<212>  PRT
<213>  Homo sapiens

<400>  145

Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
1               5                   10                  15      


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
            20                  25                  30          


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
        35                  40                  45              


Pro Gln Val Lys Phe Asn Trp Tyr Val Asp Gly Val Gln Val His Asn 
    50                  55                  60                  


Ala Lys Thr Lys Pro Arg Glu Gln Gln Tyr Asn Ser Thr Tyr Arg Val 
65                  70                  75                  80  


Val Ser Val Leu Thr Val Leu His Gln Asn Trp Leu Asp Gly Lys Glu 
                85                  90                  95      


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
            100                 105                 110         


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
        115                 120                 125             


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
    130                 135                 140                 


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
145                 150                 155                 160 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
                165                 170                 175     


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
            180                 185                 190         


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
        195                 200                 205             


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
    210                 215                 220                 


Lys 
225 


<210>  146
<211>  275
<212>  PRT
<213>  Homo sapiens

<400>  146

Met Asp Pro Lys Gln Thr Thr Leu Leu Cys Leu Gly Asp Phe Pro Met 
1               5                   10                  15      


Pro Phe Ile Ser Ala Lys Ser Ser Pro Val Ile Pro Leu Asp Gly Ser 
            20                  25                  30          


Val Lys Ile Gln Cys Gln Ala Ile Arg Glu Ala Tyr Leu Thr Gln Leu 
        35                  40                  45              


Met Ile Ile Lys Asn Ser Thr Tyr Arg Glu Ile Gly Arg Arg Leu Lys 
    50                  55                  60                  


Phe Trp Asn Glu Thr Asp Pro Glu Phe Val Ile Asp His Met Asp Ala 
65                  70                  75                  80  


Asn Lys Ala Gly Arg Tyr Gln Cys Gln Tyr Arg Ile Gly His Tyr Arg 
                85                  90                  95      


Phe Arg Tyr Ser Asp Thr Leu Glu Leu Val Val Thr Gly Leu Tyr Gly 
            100                 105                 110         


Lys Pro Phe Leu Ser Ala Asp Arg Gly Leu Val Leu Met Pro Gly Glu 
        115                 120                 125             


Asn Ile Ser Leu Thr Cys Ser Ser Ala His Ile Pro Phe Asp Arg Phe 
    130                 135                 140                 


Ser Leu Ala Lys Glu Gly Glu Leu Ser Leu Pro Gln His Gln Ser Gly 
145                 150                 155                 160 


Glu His Pro Ala Asn Phe Ser Leu Gly Pro Val Asp Leu Asn Val Ser 
                165                 170                 175     


Gly Ile Tyr Arg Cys Tyr Gly Trp Tyr Asn Arg Ser Pro Tyr Leu Trp 
            180                 185                 190         


Ser Phe Pro Ser Asn Ala Leu Glu Leu Val Val Thr Asp Ser Ile His 
        195                 200                 205             


Gln Asp Tyr Thr Thr Gln Asn Leu Ile Arg Met Ala Val Ala Gly Leu 
    210                 215                 220                 


Val Leu Val Ala Leu Leu Ala Ile Leu Val Glu Asn Trp His Ser His 
225                 230                 235                 240 


Thr Ala Leu Asn Lys Glu Ala Ser Ala Asp Val Ala Glu Pro Ser Trp 
                245                 250                 255     


Ser Gln Gln Met Cys Gln Pro Gly Leu Thr Phe Ala Arg Thr Pro Ser 
            260                 265                 270         


Val Cys Lys 
        275 


<210>  147
<211>  594
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  D30E ACE2 mutant

<400>  147

Ile Glu Glu Gln Ala Lys Thr Phe Leu Glu Lys Phe Asn His Glu Ala 
1               5                   10                  15      


Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ser Trp Asn Tyr Asn Thr 
            20                  25                  30          


Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn Ala Gly Asp Lys 
        35                  40                  45              


Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Leu Ala Gln Met Tyr Pro 
    50                  55                  60                  


Leu Gln Glu Ile Gln Asn Leu Thr Val Lys Leu Gln Leu Gln Ala Leu 
65                  70                  75                  80  


Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys Ser Lys Arg Leu 
                85                  90                  95      


Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser Thr Gly Lys Val 
            100                 105                 110         


Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu Glu Pro Gly Leu 
        115                 120                 125             


Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu Arg Leu Trp Ala 
    130                 135                 140                 


Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu Arg Pro Leu Tyr 
145                 150                 155                 160 


Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg Ala Asn His Tyr 
                165                 170                 175     


Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu Val Asn Gly Val 
            180                 185                 190         


Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu Asp Val Glu His 
        195                 200                 205             


Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu His Ala Tyr Val 
    210                 215                 220                 


Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile Ser Pro Ile Gly 
225                 230                 235                 240 


Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly Arg Phe Trp Thr 
                245                 250                 255     


Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys Pro Asn Ile Asp 
            260                 265                 270         


Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala Gln Arg Ile Phe 
        275                 280                 285             


Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu Pro Asn Met Thr 
    290                 295                 300                 


Gln Gly Phe Trp Glu Asn Ser Met Leu Thr Asp Pro Gly Asn Val Gln 
305                 310                 315                 320 


Lys Ala Val Cys His Pro Thr Ala Trp Asp Leu Gly Lys Gly Asp Phe 
                325                 330                 335     


Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp Phe Leu Thr Ala 
            340                 345                 350         


His His Glu Met Gly His Ile Gln Tyr Asp Met Ala Tyr Ala Ala Gln 
        355                 360                 365             


Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe His Glu Ala Val 
    370                 375                 380                 


Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys His Leu Lys Ser 
385                 390                 395                 400 


Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn Glu Thr Glu Ile 
                405                 410                 415     


Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly Thr Leu Pro Phe 
            420                 425                 430         


Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe Lys Gly Glu Ile 
        435                 440                 445             


Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met Lys Arg Glu Ile 
    450                 455                 460                 


Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr Tyr Cys Asp Pro 
465                 470                 475                 480 


Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe Ile Arg Tyr Tyr 
                485                 490                 495     


Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala Leu Cys Gln Ala 
            500                 505                 510         


Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile Ser Asn Ser Thr 
        515                 520                 525             


Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu Gly Lys Ser Glu 
    530                 535                 540                 


Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala Lys Asn Met Asn 
545                 550                 555                 560 


Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe Thr Trp Leu Lys 
                565                 570                 575     


Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr Asp Trp Ser Pro 
            580                 585                 590         


Tyr Ala 
        


<210>  148
<211>  594
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  D38M ACE2 mutant

<400>  148

Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Lys Phe Asn His Glu Ala 
1               5                   10                  15      


Met Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ser Trp Asn Tyr Asn Thr 
            20                  25                  30          


Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn Ala Gly Asp Lys 
        35                  40                  45              


Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Leu Ala Gln Met Tyr Pro 
    50                  55                  60                  


Leu Gln Glu Ile Gln Asn Leu Thr Val Lys Leu Gln Leu Gln Ala Leu 
65                  70                  75                  80  


Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys Ser Lys Arg Leu 
                85                  90                  95      


Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser Thr Gly Lys Val 
            100                 105                 110         


Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu Glu Pro Gly Leu 
        115                 120                 125             


Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu Arg Leu Trp Ala 
    130                 135                 140                 


Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu Arg Pro Leu Tyr 
145                 150                 155                 160 


Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg Ala Asn His Tyr 
                165                 170                 175     


Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu Val Asn Gly Val 
            180                 185                 190         


Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu Asp Val Glu His 
        195                 200                 205             


Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu His Ala Tyr Val 
    210                 215                 220                 


Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile Ser Pro Ile Gly 
225                 230                 235                 240 


Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly Arg Phe Trp Thr 
                245                 250                 255     


Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys Pro Asn Ile Asp 
            260                 265                 270         


Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala Gln Arg Ile Phe 
        275                 280                 285             


Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu Pro Asn Met Thr 
    290                 295                 300                 


Gln Gly Phe Trp Glu Asn Ser Met Leu Thr Asp Pro Gly Asn Val Gln 
305                 310                 315                 320 


Lys Ala Val Cys His Pro Thr Ala Trp Asp Leu Gly Lys Gly Asp Phe 
                325                 330                 335     


Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp Phe Leu Thr Ala 
            340                 345                 350         


His His Glu Met Gly His Ile Gln Tyr Asp Met Ala Tyr Ala Ala Gln 
        355                 360                 365             


Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe His Glu Ala Val 
    370                 375                 380                 


Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys His Leu Lys Ser 
385                 390                 395                 400 


Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn Glu Thr Glu Ile 
                405                 410                 415     


Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly Thr Leu Pro Phe 
            420                 425                 430         


Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe Lys Gly Glu Ile 
        435                 440                 445             


Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met Lys Arg Glu Ile 
    450                 455                 460                 


Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr Tyr Cys Asp Pro 
465                 470                 475                 480 


Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe Ile Arg Tyr Tyr 
                485                 490                 495     


Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala Leu Cys Gln Ala 
            500                 505                 510         


Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile Ser Asn Ser Thr 
        515                 520                 525             


Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu Gly Lys Ser Glu 
    530                 535                 540                 


Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala Lys Asn Met Asn 
545                 550                 555                 560 


Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe Thr Trp Leu Lys 
                565                 570                 575     


Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr Asp Trp Ser Pro 
            580                 585                 590         


Tyr Ala 
        


<210>  149
<211>  594
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  D38W ACE2 mutant

<400>  149

Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Lys Phe Asn His Glu Ala 
1               5                   10                  15      


Trp Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ser Trp Asn Tyr Asn Thr 
            20                  25                  30          


Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn Ala Gly Asp Lys 
        35                  40                  45              


Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Leu Ala Gln Met Tyr Pro 
    50                  55                  60                  


Leu Gln Glu Ile Gln Asn Leu Thr Val Lys Leu Gln Leu Gln Ala Leu 
65                  70                  75                  80  


Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys Ser Lys Arg Leu 
                85                  90                  95      


Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser Thr Gly Lys Val 
            100                 105                 110         


Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu Glu Pro Gly Leu 
        115                 120                 125             


Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu Arg Leu Trp Ala 
    130                 135                 140                 


Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu Arg Pro Leu Tyr 
145                 150                 155                 160 


Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg Ala Asn His Tyr 
                165                 170                 175     


Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu Val Asn Gly Val 
            180                 185                 190         


Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu Asp Val Glu His 
        195                 200                 205             


Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu His Ala Tyr Val 
    210                 215                 220                 


Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile Ser Pro Ile Gly 
225                 230                 235                 240 


Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly Arg Phe Trp Thr 
                245                 250                 255     


Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys Pro Asn Ile Asp 
            260                 265                 270         


Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala Gln Arg Ile Phe 
        275                 280                 285             


Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu Pro Asn Met Thr 
    290                 295                 300                 


Gln Gly Phe Trp Glu Asn Ser Met Leu Thr Asp Pro Gly Asn Val Gln 
305                 310                 315                 320 


Lys Ala Val Cys His Pro Thr Ala Trp Asp Leu Gly Lys Gly Asp Phe 
                325                 330                 335     


Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp Phe Leu Thr Ala 
            340                 345                 350         


His His Glu Met Gly His Ile Gln Tyr Asp Met Ala Tyr Ala Ala Gln 
        355                 360                 365             


Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe His Glu Ala Val 
    370                 375                 380                 


Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys His Leu Lys Ser 
385                 390                 395                 400 


Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn Glu Thr Glu Ile 
                405                 410                 415     


Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly Thr Leu Pro Phe 
            420                 425                 430         


Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe Lys Gly Glu Ile 
        435                 440                 445             


Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met Lys Arg Glu Ile 
    450                 455                 460                 


Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr Tyr Cys Asp Pro 
465                 470                 475                 480 


Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe Ile Arg Tyr Tyr 
                485                 490                 495     


Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala Leu Cys Gln Ala 
            500                 505                 510         


Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile Ser Asn Ser Thr 
        515                 520                 525             


Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu Gly Lys Ser Glu 
    530                 535                 540                 


Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala Lys Asn Met Asn 
545                 550                 555                 560 


Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe Thr Trp Leu Lys 
                565                 570                 575     


Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr Asp Trp Ser Pro 
            580                 585                 590         


Tyr Ala 
        


<210>  150
<211>  594
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  D38Y ACE2 mutant

<400>  150

Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Lys Phe Asn His Glu Ala 
1               5                   10                  15      


Tyr Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ser Trp Asn Tyr Asn Thr 
            20                  25                  30          


Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn Ala Gly Asp Lys 
        35                  40                  45              


Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Leu Ala Gln Met Tyr Pro 
    50                  55                  60                  


Leu Gln Glu Ile Gln Asn Leu Thr Val Lys Leu Gln Leu Gln Ala Leu 
65                  70                  75                  80  


Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys Ser Lys Arg Leu 
                85                  90                  95      


Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser Thr Gly Lys Val 
            100                 105                 110         


Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu Glu Pro Gly Leu 
        115                 120                 125             


Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu Arg Leu Trp Ala 
    130                 135                 140                 


Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu Arg Pro Leu Tyr 
145                 150                 155                 160 


Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg Ala Asn His Tyr 
                165                 170                 175     


Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu Val Asn Gly Val 
            180                 185                 190         


Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu Asp Val Glu His 
        195                 200                 205             


Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu His Ala Tyr Val 
    210                 215                 220                 


Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile Ser Pro Ile Gly 
225                 230                 235                 240 


Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly Arg Phe Trp Thr 
                245                 250                 255     


Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys Pro Asn Ile Asp 
            260                 265                 270         


Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala Gln Arg Ile Phe 
        275                 280                 285             


Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu Pro Asn Met Thr 
    290                 295                 300                 


Gln Gly Phe Trp Glu Asn Ser Met Leu Thr Asp Pro Gly Asn Val Gln 
305                 310                 315                 320 


Lys Ala Val Cys His Pro Thr Ala Trp Asp Leu Gly Lys Gly Asp Phe 
                325                 330                 335     


Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp Phe Leu Thr Ala 
            340                 345                 350         


His His Glu Met Gly His Ile Gln Tyr Asp Met Ala Tyr Ala Ala Gln 
        355                 360                 365             


Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe His Glu Ala Val 
    370                 375                 380                 


Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys His Leu Lys Ser 
385                 390                 395                 400 


Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn Glu Thr Glu Ile 
                405                 410                 415     


Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly Thr Leu Pro Phe 
            420                 425                 430         


Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe Lys Gly Glu Ile 
        435                 440                 445             


Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met Lys Arg Glu Ile 
    450                 455                 460                 


Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr Tyr Cys Asp Pro 
465                 470                 475                 480 


Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe Ile Arg Tyr Tyr 
                485                 490                 495     


Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala Leu Cys Gln Ala 
            500                 505                 510         


Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile Ser Asn Ser Thr 
        515                 520                 525             


Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu Gly Lys Ser Glu 
    530                 535                 540                 


Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala Lys Asn Met Asn 
545                 550                 555                 560 


Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe Thr Trp Leu Lys 
                565                 570                 575     


Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr Asp Trp Ser Pro 
            580                 585                 590         


Tyr Ala 
        


<210>  151
<211>  594
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H34E ACE2 mutant

<400>  151

Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Lys Phe Asn Glu Glu Ala 
1               5                   10                  15      


Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ser Trp Asn Tyr Asn Thr 
            20                  25                  30          


Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn Ala Gly Asp Lys 
        35                  40                  45              


Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Leu Ala Gln Met Tyr Pro 
    50                  55                  60                  


Leu Gln Glu Ile Gln Asn Leu Thr Val Lys Leu Gln Leu Gln Ala Leu 
65                  70                  75                  80  


Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys Ser Lys Arg Leu 
                85                  90                  95      


Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser Thr Gly Lys Val 
            100                 105                 110         


Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu Glu Pro Gly Leu 
        115                 120                 125             


Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu Arg Leu Trp Ala 
    130                 135                 140                 


Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu Arg Pro Leu Tyr 
145                 150                 155                 160 


Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg Ala Asn His Tyr 
                165                 170                 175     


Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu Val Asn Gly Val 
            180                 185                 190         


Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu Asp Val Glu His 
        195                 200                 205             


Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu His Ala Tyr Val 
    210                 215                 220                 


Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile Ser Pro Ile Gly 
225                 230                 235                 240 


Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly Arg Phe Trp Thr 
                245                 250                 255     


Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys Pro Asn Ile Asp 
            260                 265                 270         


Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala Gln Arg Ile Phe 
        275                 280                 285             


Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu Pro Asn Met Thr 
    290                 295                 300                 


Gln Gly Phe Trp Glu Asn Ser Met Leu Thr Asp Pro Gly Asn Val Gln 
305                 310                 315                 320 


Lys Ala Val Cys His Pro Thr Ala Trp Asp Leu Gly Lys Gly Asp Phe 
                325                 330                 335     


Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp Phe Leu Thr Ala 
            340                 345                 350         


His His Glu Met Gly His Ile Gln Tyr Asp Met Ala Tyr Ala Ala Gln 
        355                 360                 365             


Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe His Glu Ala Val 
    370                 375                 380                 


Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys His Leu Lys Ser 
385                 390                 395                 400 


Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn Glu Thr Glu Ile 
                405                 410                 415     


Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly Thr Leu Pro Phe 
            420                 425                 430         


Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe Lys Gly Glu Ile 
        435                 440                 445             


Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met Lys Arg Glu Ile 
    450                 455                 460                 


Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr Tyr Cys Asp Pro 
465                 470                 475                 480 


Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe Ile Arg Tyr Tyr 
                485                 490                 495     


Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala Leu Cys Gln Ala 
            500                 505                 510         


Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile Ser Asn Ser Thr 
        515                 520                 525             


Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu Gly Lys Ser Glu 
    530                 535                 540                 


Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala Lys Asn Met Asn 
545                 550                 555                 560 


Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe Thr Trp Leu Lys 
                565                 570                 575     


Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr Asp Trp Ser Pro 
            580                 585                 590         


Tyr Ala 
        


<210>  152
<211>  594
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H34F ACE2 mutant

<400>  152

Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Lys Phe Asn Phe Glu Ala 
1               5                   10                  15      


Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ser Trp Asn Tyr Asn Thr 
            20                  25                  30          


Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn Ala Gly Asp Lys 
        35                  40                  45              


Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Leu Ala Gln Met Tyr Pro 
    50                  55                  60                  


Leu Gln Glu Ile Gln Asn Leu Thr Val Lys Leu Gln Leu Gln Ala Leu 
65                  70                  75                  80  


Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys Ser Lys Arg Leu 
                85                  90                  95      


Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser Thr Gly Lys Val 
            100                 105                 110         


Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu Glu Pro Gly Leu 
        115                 120                 125             


Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu Arg Leu Trp Ala 
    130                 135                 140                 


Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu Arg Pro Leu Tyr 
145                 150                 155                 160 


Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg Ala Asn His Tyr 
                165                 170                 175     


Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu Val Asn Gly Val 
            180                 185                 190         


Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu Asp Val Glu His 
        195                 200                 205             


Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu His Ala Tyr Val 
    210                 215                 220                 


Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile Ser Pro Ile Gly 
225                 230                 235                 240 


Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly Arg Phe Trp Thr 
                245                 250                 255     


Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys Pro Asn Ile Asp 
            260                 265                 270         


Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala Gln Arg Ile Phe 
        275                 280                 285             


Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu Pro Asn Met Thr 
    290                 295                 300                 


Gln Gly Phe Trp Glu Asn Ser Met Leu Thr Asp Pro Gly Asn Val Gln 
305                 310                 315                 320 


Lys Ala Val Cys His Pro Thr Ala Trp Asp Leu Gly Lys Gly Asp Phe 
                325                 330                 335     


Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp Phe Leu Thr Ala 
            340                 345                 350         


His His Glu Met Gly His Ile Gln Tyr Asp Met Ala Tyr Ala Ala Gln 
        355                 360                 365             


Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe His Glu Ala Val 
    370                 375                 380                 


Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys His Leu Lys Ser 
385                 390                 395                 400 


Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn Glu Thr Glu Ile 
                405                 410                 415     


Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly Thr Leu Pro Phe 
            420                 425                 430         


Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe Lys Gly Glu Ile 
        435                 440                 445             


Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met Lys Arg Glu Ile 
    450                 455                 460                 


Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr Tyr Cys Asp Pro 
465                 470                 475                 480 


Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe Ile Arg Tyr Tyr 
                485                 490                 495     


Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala Leu Cys Gln Ala 
            500                 505                 510         


Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile Ser Asn Ser Thr 
        515                 520                 525             


Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu Gly Lys Ser Glu 
    530                 535                 540                 


Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala Lys Asn Met Asn 
545                 550                 555                 560 


Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe Thr Trp Leu Lys 
                565                 570                 575     


Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr Asp Trp Ser Pro 
            580                 585                 590         


Tyr Ala 
        


<210>  153
<211>  594
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H34K ACE2 mutant

<400>  153

Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Lys Phe Asn Lys Glu Ala 
1               5                   10                  15      


Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ser Trp Asn Tyr Asn Thr 
            20                  25                  30          


Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn Ala Gly Asp Lys 
        35                  40                  45              


Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Leu Ala Gln Met Tyr Pro 
    50                  55                  60                  


Leu Gln Glu Ile Gln Asn Leu Thr Val Lys Leu Gln Leu Gln Ala Leu 
65                  70                  75                  80  


Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys Ser Lys Arg Leu 
                85                  90                  95      


Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser Thr Gly Lys Val 
            100                 105                 110         


Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu Glu Pro Gly Leu 
        115                 120                 125             


Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu Arg Leu Trp Ala 
    130                 135                 140                 


Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu Arg Pro Leu Tyr 
145                 150                 155                 160 


Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg Ala Asn His Tyr 
                165                 170                 175     


Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu Val Asn Gly Val 
            180                 185                 190         


Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu Asp Val Glu His 
        195                 200                 205             


Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu His Ala Tyr Val 
    210                 215                 220                 


Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile Ser Pro Ile Gly 
225                 230                 235                 240 


Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly Arg Phe Trp Thr 
                245                 250                 255     


Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys Pro Asn Ile Asp 
            260                 265                 270         


Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala Gln Arg Ile Phe 
        275                 280                 285             


Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu Pro Asn Met Thr 
    290                 295                 300                 


Gln Gly Phe Trp Glu Asn Ser Met Leu Thr Asp Pro Gly Asn Val Gln 
305                 310                 315                 320 


Lys Ala Val Cys His Pro Thr Ala Trp Asp Leu Gly Lys Gly Asp Phe 
                325                 330                 335     


Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp Phe Leu Thr Ala 
            340                 345                 350         


His His Glu Met Gly His Ile Gln Tyr Asp Met Ala Tyr Ala Ala Gln 
        355                 360                 365             


Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe His Glu Ala Val 
    370                 375                 380                 


Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys His Leu Lys Ser 
385                 390                 395                 400 


Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn Glu Thr Glu Ile 
                405                 410                 415     


Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly Thr Leu Pro Phe 
            420                 425                 430         


Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe Lys Gly Glu Ile 
        435                 440                 445             


Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met Lys Arg Glu Ile 
    450                 455                 460                 


Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr Tyr Cys Asp Pro 
465                 470                 475                 480 


Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe Ile Arg Tyr Tyr 
                485                 490                 495     


Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala Leu Cys Gln Ala 
            500                 505                 510         


Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile Ser Asn Ser Thr 
        515                 520                 525             


Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu Gly Lys Ser Glu 
    530                 535                 540                 


Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala Lys Asn Met Asn 
545                 550                 555                 560 


Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe Thr Trp Leu Lys 
                565                 570                 575     


Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr Asp Trp Ser Pro 
            580                 585                 590         


Tyr Ala 
        


<210>  154
<211>  594
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H34M ACE2 mutant

<400>  154

Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Lys Phe Asn Met Glu Ala 
1               5                   10                  15      


Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ser Trp Asn Tyr Asn Thr 
            20                  25                  30          


Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn Ala Gly Asp Lys 
        35                  40                  45              


Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Leu Ala Gln Met Tyr Pro 
    50                  55                  60                  


Leu Gln Glu Ile Gln Asn Leu Thr Val Lys Leu Gln Leu Gln Ala Leu 
65                  70                  75                  80  


Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys Ser Lys Arg Leu 
                85                  90                  95      


Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser Thr Gly Lys Val 
            100                 105                 110         


Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu Glu Pro Gly Leu 
        115                 120                 125             


Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu Arg Leu Trp Ala 
    130                 135                 140                 


Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu Arg Pro Leu Tyr 
145                 150                 155                 160 


Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg Ala Asn His Tyr 
                165                 170                 175     


Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu Val Asn Gly Val 
            180                 185                 190         


Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu Asp Val Glu His 
        195                 200                 205             


Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu His Ala Tyr Val 
    210                 215                 220                 


Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile Ser Pro Ile Gly 
225                 230                 235                 240 


Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly Arg Phe Trp Thr 
                245                 250                 255     


Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys Pro Asn Ile Asp 
            260                 265                 270         


Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala Gln Arg Ile Phe 
        275                 280                 285             


Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu Pro Asn Met Thr 
    290                 295                 300                 


Gln Gly Phe Trp Glu Asn Ser Met Leu Thr Asp Pro Gly Asn Val Gln 
305                 310                 315                 320 


Lys Ala Val Cys His Pro Thr Ala Trp Asp Leu Gly Lys Gly Asp Phe 
                325                 330                 335     


Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp Phe Leu Thr Ala 
            340                 345                 350         


His His Glu Met Gly His Ile Gln Tyr Asp Met Ala Tyr Ala Ala Gln 
        355                 360                 365             


Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe His Glu Ala Val 
    370                 375                 380                 


Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys His Leu Lys Ser 
385                 390                 395                 400 


Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn Glu Thr Glu Ile 
                405                 410                 415     


Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly Thr Leu Pro Phe 
            420                 425                 430         


Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe Lys Gly Glu Ile 
        435                 440                 445             


Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met Lys Arg Glu Ile 
    450                 455                 460                 


Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr Tyr Cys Asp Pro 
465                 470                 475                 480 


Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe Ile Arg Tyr Tyr 
                485                 490                 495     


Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala Leu Cys Gln Ala 
            500                 505                 510         


Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile Ser Asn Ser Thr 
        515                 520                 525             


Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu Gly Lys Ser Glu 
    530                 535                 540                 


Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala Lys Asn Met Asn 
545                 550                 555                 560 


Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe Thr Trp Leu Lys 
                565                 570                 575     


Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr Asp Trp Ser Pro 
            580                 585                 590         


Tyr Ala 
        


<210>  155
<211>  594
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H34W ACE2 mutant

<400>  155

Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Lys Phe Asn Trp Glu Ala 
1               5                   10                  15      


Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ser Trp Asn Tyr Asn Thr 
            20                  25                  30          


Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn Ala Gly Asp Lys 
        35                  40                  45              


Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Leu Ala Gln Met Tyr Pro 
    50                  55                  60                  


Leu Gln Glu Ile Gln Asn Leu Thr Val Lys Leu Gln Leu Gln Ala Leu 
65                  70                  75                  80  


Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys Ser Lys Arg Leu 
                85                  90                  95      


Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser Thr Gly Lys Val 
            100                 105                 110         


Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu Glu Pro Gly Leu 
        115                 120                 125             


Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu Arg Leu Trp Ala 
    130                 135                 140                 


Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu Arg Pro Leu Tyr 
145                 150                 155                 160 


Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg Ala Asn His Tyr 
                165                 170                 175     


Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu Val Asn Gly Val 
            180                 185                 190         


Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu Asp Val Glu His 
        195                 200                 205             


Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu His Ala Tyr Val 
    210                 215                 220                 


Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile Ser Pro Ile Gly 
225                 230                 235                 240 


Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly Arg Phe Trp Thr 
                245                 250                 255     


Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys Pro Asn Ile Asp 
            260                 265                 270         


Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala Gln Arg Ile Phe 
        275                 280                 285             


Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu Pro Asn Met Thr 
    290                 295                 300                 


Gln Gly Phe Trp Glu Asn Ser Met Leu Thr Asp Pro Gly Asn Val Gln 
305                 310                 315                 320 


Lys Ala Val Cys His Pro Thr Ala Trp Asp Leu Gly Lys Gly Asp Phe 
                325                 330                 335     


Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp Phe Leu Thr Ala 
            340                 345                 350         


His His Glu Met Gly His Ile Gln Tyr Asp Met Ala Tyr Ala Ala Gln 
        355                 360                 365             


Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe His Glu Ala Val 
    370                 375                 380                 


Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys His Leu Lys Ser 
385                 390                 395                 400 


Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn Glu Thr Glu Ile 
                405                 410                 415     


Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly Thr Leu Pro Phe 
            420                 425                 430         


Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe Lys Gly Glu Ile 
        435                 440                 445             


Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met Lys Arg Glu Ile 
    450                 455                 460                 


Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr Tyr Cys Asp Pro 
465                 470                 475                 480 


Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe Ile Arg Tyr Tyr 
                485                 490                 495     


Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala Leu Cys Gln Ala 
            500                 505                 510         


Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile Ser Asn Ser Thr 
        515                 520                 525             


Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu Gly Lys Ser Glu 
    530                 535                 540                 


Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala Lys Asn Met Asn 
545                 550                 555                 560 


Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe Thr Trp Leu Lys 
                565                 570                 575     


Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr Asp Trp Ser Pro 
            580                 585                 590         


Tyr Ala 
        


<210>  156
<211>  594
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H34Y ACE2 mutant

<400>  156

Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Lys Phe Asn Phe Glu Ala 
1               5                   10                  15      


Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ser Trp Asn Tyr Asn Thr 
            20                  25                  30          


Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn Ala Gly Asp Lys 
        35                  40                  45              


Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Leu Ala Gln Met Tyr Pro 
    50                  55                  60                  


Leu Gln Glu Ile Gln Asn Leu Thr Val Lys Leu Gln Leu Gln Ala Leu 
65                  70                  75                  80  


Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys Ser Lys Arg Leu 
                85                  90                  95      


Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser Thr Gly Lys Val 
            100                 105                 110         


Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu Glu Pro Gly Leu 
        115                 120                 125             


Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu Arg Leu Trp Ala 
    130                 135                 140                 


Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu Arg Pro Leu Tyr 
145                 150                 155                 160 


Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg Ala Asn His Tyr 
                165                 170                 175     


Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu Val Asn Gly Val 
            180                 185                 190         


Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu Asp Val Glu His 
        195                 200                 205             


Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu His Ala Tyr Val 
    210                 215                 220                 


Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile Ser Pro Ile Gly 
225                 230                 235                 240 


Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly Arg Phe Trp Thr 
                245                 250                 255     


Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys Pro Asn Ile Asp 
            260                 265                 270         


Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala Gln Arg Ile Phe 
        275                 280                 285             


Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu Pro Asn Met Thr 
    290                 295                 300                 


Gln Gly Phe Trp Glu Asn Ser Met Leu Thr Asp Pro Gly Asn Val Gln 
305                 310                 315                 320 


Lys Ala Val Cys His Pro Thr Ala Trp Asp Leu Gly Lys Gly Asp Phe 
                325                 330                 335     


Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp Phe Leu Thr Ala 
            340                 345                 350         


His His Glu Met Gly His Ile Gln Tyr Asp Met Ala Tyr Ala Ala Gln 
        355                 360                 365             


Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe His Glu Ala Val 
    370                 375                 380                 


Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys His Leu Lys Ser 
385                 390                 395                 400 


Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn Glu Thr Glu Ile 
                405                 410                 415     


Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly Thr Leu Pro Phe 
            420                 425                 430         


Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe Lys Gly Glu Ile 
        435                 440                 445             


Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met Lys Arg Glu Ile 
    450                 455                 460                 


Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr Tyr Cys Asp Pro 
465                 470                 475                 480 


Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe Ile Arg Tyr Tyr 
                485                 490                 495     


Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala Leu Cys Gln Ala 
            500                 505                 510         


Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile Ser Asn Ser Thr 
        515                 520                 525             


Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu Gly Lys Ser Glu 
    530                 535                 540                 


Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala Lys Asn Met Asn 
545                 550                 555                 560 


Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe Thr Trp Leu Lys 
                565                 570                 575     


Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr Asp Trp Ser Pro 
            580                 585                 590         


Tyr Ala 
        


<210>  157
<211>  594
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  T27F ACE2 mutant

<400>  157

Ile Glu Glu Gln Ala Lys Phe Phe Leu Asp Lys Phe Asn His Glu Ala 
1               5                   10                  15      


Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ser Trp Asn Tyr Asn Thr 
            20                  25                  30          


Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn Ala Gly Asp Lys 
        35                  40                  45              


Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Leu Ala Gln Met Tyr Pro 
    50                  55                  60                  


Leu Gln Glu Ile Gln Asn Leu Thr Val Lys Leu Gln Leu Gln Ala Leu 
65                  70                  75                  80  


Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys Ser Lys Arg Leu 
                85                  90                  95      


Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser Thr Gly Lys Val 
            100                 105                 110         


Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu Glu Pro Gly Leu 
        115                 120                 125             


Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu Arg Leu Trp Ala 
    130                 135                 140                 


Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu Arg Pro Leu Tyr 
145                 150                 155                 160 


Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg Ala Asn His Tyr 
                165                 170                 175     


Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu Val Asn Gly Val 
            180                 185                 190         


Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu Asp Val Glu His 
        195                 200                 205             


Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu His Ala Tyr Val 
    210                 215                 220                 


Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile Ser Pro Ile Gly 
225                 230                 235                 240 


Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly Arg Phe Trp Thr 
                245                 250                 255     


Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys Pro Asn Ile Asp 
            260                 265                 270         


Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala Gln Arg Ile Phe 
        275                 280                 285             


Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu Pro Asn Met Thr 
    290                 295                 300                 


Gln Gly Phe Trp Glu Asn Ser Met Leu Thr Asp Pro Gly Asn Val Gln 
305                 310                 315                 320 


Lys Ala Val Cys His Pro Thr Ala Trp Asp Leu Gly Lys Gly Asp Phe 
                325                 330                 335     


Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp Phe Leu Thr Ala 
            340                 345                 350         


His His Glu Met Gly His Ile Gln Tyr Asp Met Ala Tyr Ala Ala Gln 
        355                 360                 365             


Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe His Glu Ala Val 
    370                 375                 380                 


Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys His Leu Lys Ser 
385                 390                 395                 400 


Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn Glu Thr Glu Ile 
                405                 410                 415     


Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly Thr Leu Pro Phe 
            420                 425                 430         


Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe Lys Gly Glu Ile 
        435                 440                 445             


Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met Lys Arg Glu Ile 
    450                 455                 460                 


Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr Tyr Cys Asp Pro 
465                 470                 475                 480 


Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe Ile Arg Tyr Tyr 
                485                 490                 495     


Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala Leu Cys Gln Ala 
            500                 505                 510         


Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile Ser Asn Ser Thr 
        515                 520                 525             


Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu Gly Lys Ser Glu 
    530                 535                 540                 


Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala Lys Asn Met Asn 
545                 550                 555                 560 


Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe Thr Trp Leu Lys 
                565                 570                 575     


Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr Asp Trp Ser Pro 
            580                 585                 590         


Tyr Ala 
        


<210>  158
<211>  594
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  T27W ACE2 mutant

<400>  158

Ile Glu Glu Gln Ala Lys Trp Phe Leu Asp Lys Phe Asn His Glu Ala 
1               5                   10                  15      


Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ser Trp Asn Tyr Asn Thr 
            20                  25                  30          


Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn Ala Gly Asp Lys 
        35                  40                  45              


Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Leu Ala Gln Met Tyr Pro 
    50                  55                  60                  


Leu Gln Glu Ile Gln Asn Leu Thr Val Lys Leu Gln Leu Gln Ala Leu 
65                  70                  75                  80  


Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys Ser Lys Arg Leu 
                85                  90                  95      


Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser Thr Gly Lys Val 
            100                 105                 110         


Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu Glu Pro Gly Leu 
        115                 120                 125             


Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu Arg Leu Trp Ala 
    130                 135                 140                 


Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu Arg Pro Leu Tyr 
145                 150                 155                 160 


Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg Ala Asn His Tyr 
                165                 170                 175     


Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu Val Asn Gly Val 
            180                 185                 190         


Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu Asp Val Glu His 
        195                 200                 205             


Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu His Ala Tyr Val 
    210                 215                 220                 


Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile Ser Pro Ile Gly 
225                 230                 235                 240 


Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly Arg Phe Trp Thr 
                245                 250                 255     


Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys Pro Asn Ile Asp 
            260                 265                 270         


Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala Gln Arg Ile Phe 
        275                 280                 285             


Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu Pro Asn Met Thr 
    290                 295                 300                 


Gln Gly Phe Trp Glu Asn Ser Met Leu Thr Asp Pro Gly Asn Val Gln 
305                 310                 315                 320 


Lys Ala Val Cys His Pro Thr Ala Trp Asp Leu Gly Lys Gly Asp Phe 
                325                 330                 335     


Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp Phe Leu Thr Ala 
            340                 345                 350         


His His Glu Met Gly His Ile Gln Tyr Asp Met Ala Tyr Ala Ala Gln 
        355                 360                 365             


Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe His Glu Ala Val 
    370                 375                 380                 


Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys His Leu Lys Ser 
385                 390                 395                 400 


Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn Glu Thr Glu Ile 
                405                 410                 415     


Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly Thr Leu Pro Phe 
            420                 425                 430         


Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe Lys Gly Glu Ile 
        435                 440                 445             


Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met Lys Arg Glu Ile 
    450                 455                 460                 


Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr Tyr Cys Asp Pro 
465                 470                 475                 480 


Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe Ile Arg Tyr Tyr 
                485                 490                 495     


Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala Leu Cys Gln Ala 
            500                 505                 510         


Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile Ser Asn Ser Thr 
        515                 520                 525             


Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu Gly Lys Ser Glu 
    530                 535                 540                 


Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala Lys Asn Met Asn 
545                 550                 555                 560 


Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe Thr Trp Leu Lys 
                565                 570                 575     


Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr Asp Trp Ser Pro 
            580                 585                 590         


Tyr Ala 
        


<210>  159
<211>  594
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  T27Y ACE2 mutant

<400>  159

Ile Glu Glu Gln Ala Lys Tyr Phe Leu Asp Lys Phe Asn His Glu Ala 
1               5                   10                  15      


Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ser Trp Asn Tyr Asn Thr 
            20                  25                  30          


Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn Ala Gly Asp Lys 
        35                  40                  45              


Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Leu Ala Gln Met Tyr Pro 
    50                  55                  60                  


Leu Gln Glu Ile Gln Asn Leu Thr Val Lys Leu Gln Leu Gln Ala Leu 
65                  70                  75                  80  


Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys Ser Lys Arg Leu 
                85                  90                  95      


Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser Thr Gly Lys Val 
            100                 105                 110         


Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu Glu Pro Gly Leu 
        115                 120                 125             


Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu Arg Leu Trp Ala 
    130                 135                 140                 


Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu Arg Pro Leu Tyr 
145                 150                 155                 160 


Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg Ala Asn His Tyr 
                165                 170                 175     


Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu Val Asn Gly Val 
            180                 185                 190         


Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu Asp Val Glu His 
        195                 200                 205             


Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu His Ala Tyr Val 
    210                 215                 220                 


Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile Ser Pro Ile Gly 
225                 230                 235                 240 


Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly Arg Phe Trp Thr 
                245                 250                 255     


Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys Pro Asn Ile Asp 
            260                 265                 270         


Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala Gln Arg Ile Phe 
        275                 280                 285             


Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu Pro Asn Met Thr 
    290                 295                 300                 


Gln Gly Phe Trp Glu Asn Ser Met Leu Thr Asp Pro Gly Asn Val Gln 
305                 310                 315                 320 


Lys Ala Val Cys His Pro Thr Ala Trp Asp Leu Gly Lys Gly Asp Phe 
                325                 330                 335     


Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp Phe Leu Thr Ala 
            340                 345                 350         


His His Glu Met Gly His Ile Gln Tyr Asp Met Ala Tyr Ala Ala Gln 
        355                 360                 365             


Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe His Glu Ala Val 
    370                 375                 380                 


Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys His Leu Lys Ser 
385                 390                 395                 400 


Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn Glu Thr Glu Ile 
                405                 410                 415     


Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly Thr Leu Pro Phe 
            420                 425                 430         


Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe Lys Gly Glu Ile 
        435                 440                 445             


Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met Lys Arg Glu Ile 
    450                 455                 460                 


Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr Tyr Cys Asp Pro 
465                 470                 475                 480 


Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe Ile Arg Tyr Tyr 
                485                 490                 495     


Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala Leu Cys Gln Ala 
            500                 505                 510         


Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile Ser Asn Ser Thr 
        515                 520                 525             


Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu Gly Lys Ser Glu 
    530                 535                 540                 


Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala Lys Asn Met Asn 
545                 550                 555                 560 


Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe Thr Trp Leu Lys 
                565                 570                 575     


Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr Asp Trp Ser Pro 
            580                 585                 590         


Tyr Ala 
        


<210>  160
<211>  595
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ACE2 mutant, Ala inserted at #30

<400>  160

Ile Glu Glu Gln Ala Lys Thr Phe Leu Ala Asp Lys Phe Asn His Glu 
1               5                   10                  15      


Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ser Trp Asn Tyr Asn 
            20                  25                  30          


Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn Ala Gly Asp 
        35                  40                  45              


Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Leu Ala Gln Met Tyr 
    50                  55                  60                  


Pro Leu Gln Glu Ile Gln Asn Leu Thr Val Lys Leu Gln Leu Gln Ala 
65                  70                  75                  80  


Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys Ser Lys Arg 
                85                  90                  95      


Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser Thr Gly Lys 
            100                 105                 110         


Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu Glu Pro Gly 
        115                 120                 125             


Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu Arg Leu Trp 
    130                 135                 140                 


Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu Arg Pro Leu 
145                 150                 155                 160 


Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg Ala Asn His 
                165                 170                 175     


Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu Val Asn Gly 
            180                 185                 190         


Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu Asp Val Glu 
        195                 200                 205             


His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu His Ala Tyr 
    210                 215                 220                 


Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile Ser Pro Ile 
225                 230                 235                 240 


Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly Arg Phe Trp 
                245                 250                 255     


Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys Pro Asn Ile 
            260                 265                 270         


Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala Gln Arg Ile 
        275                 280                 285             


Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu Pro Asn Met 
    290                 295                 300                 


Thr Gln Gly Phe Trp Glu Asn Ser Met Leu Thr Asp Pro Gly Asn Val 
305                 310                 315                 320 


Gln Lys Ala Val Cys His Pro Thr Ala Trp Asp Leu Gly Lys Gly Asp 
                325                 330                 335     


Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp Phe Leu Thr 
            340                 345                 350         


Ala His His Glu Met Gly His Ile Gln Tyr Asp Met Ala Tyr Ala Ala 
        355                 360                 365             


Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe His Glu Ala 
    370                 375                 380                 


Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys His Leu Lys 
385                 390                 395                 400 


Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn Glu Thr Glu 
                405                 410                 415     


Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly Thr Leu Pro 
            420                 425                 430         


Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe Lys Gly Glu 
        435                 440                 445             


Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met Lys Arg Glu 
    450                 455                 460                 


Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr Tyr Cys Asp 
465                 470                 475                 480 


Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe Ile Arg Tyr 
                485                 490                 495     


Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala Leu Cys Gln 
            500                 505                 510         


Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile Ser Asn Ser 
        515                 520                 525             


Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu Gly Lys Ser 
    530                 535                 540                 


Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala Lys Asn Met 
545                 550                 555                 560 


Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe Thr Trp Leu 
                565                 570                 575     


Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr Asp Trp Ser 
            580                 585                 590         


Pro Tyr Ala 
        595 


<210>  161
<211>  595
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ACE2 mutant, Ala inserted at #31

<400>  161

Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Ala Lys Phe Asn His Glu 
1               5                   10                  15      


Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ser Trp Asn Tyr Asn 
            20                  25                  30          


Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn Ala Gly Asp 
        35                  40                  45              


Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Leu Ala Gln Met Tyr 
    50                  55                  60                  


Pro Leu Gln Glu Ile Gln Asn Leu Thr Val Lys Leu Gln Leu Gln Ala 
65                  70                  75                  80  


Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys Ser Lys Arg 
                85                  90                  95      


Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser Thr Gly Lys 
            100                 105                 110         


Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu Glu Pro Gly 
        115                 120                 125             


Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu Arg Leu Trp 
    130                 135                 140                 


Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu Arg Pro Leu 
145                 150                 155                 160 


Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg Ala Asn His 
                165                 170                 175     


Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu Val Asn Gly 
            180                 185                 190         


Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu Asp Val Glu 
        195                 200                 205             


His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu His Ala Tyr 
    210                 215                 220                 


Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile Ser Pro Ile 
225                 230                 235                 240 


Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly Arg Phe Trp 
                245                 250                 255     


Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys Pro Asn Ile 
            260                 265                 270         


Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala Gln Arg Ile 
        275                 280                 285             


Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu Pro Asn Met 
    290                 295                 300                 


Thr Gln Gly Phe Trp Glu Asn Ser Met Leu Thr Asp Pro Gly Asn Val 
305                 310                 315                 320 


Gln Lys Ala Val Cys His Pro Thr Ala Trp Asp Leu Gly Lys Gly Asp 
                325                 330                 335     


Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp Phe Leu Thr 
            340                 345                 350         


Ala His His Glu Met Gly His Ile Gln Tyr Asp Met Ala Tyr Ala Ala 
        355                 360                 365             


Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe His Glu Ala 
    370                 375                 380                 


Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys His Leu Lys 
385                 390                 395                 400 


Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn Glu Thr Glu 
                405                 410                 415     


Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly Thr Leu Pro 
            420                 425                 430         


Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe Lys Gly Glu 
        435                 440                 445             


Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met Lys Arg Glu 
    450                 455                 460                 


Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr Tyr Cys Asp 
465                 470                 475                 480 


Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe Ile Arg Tyr 
                485                 490                 495     


Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala Leu Cys Gln 
            500                 505                 510         


Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile Ser Asn Ser 
        515                 520                 525             


Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu Gly Lys Ser 
    530                 535                 540                 


Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala Lys Asn Met 
545                 550                 555                 560 


Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe Thr Trp Leu 
                565                 570                 575     


Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr Asp Trp Ser 
            580                 585                 590         


Pro Tyr Ala 
        595 


<210>  162
<211>  595
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ACE2 mutant, Ala inserted at #32

<400>  162

Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Lys Ala Phe Asn His Glu 
1               5                   10                  15      


Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ser Trp Asn Tyr Asn 
            20                  25                  30          


Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn Ala Gly Asp 
        35                  40                  45              


Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Leu Ala Gln Met Tyr 
    50                  55                  60                  


Pro Leu Gln Glu Ile Gln Asn Leu Thr Val Lys Leu Gln Leu Gln Ala 
65                  70                  75                  80  


Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys Ser Lys Arg 
                85                  90                  95      


Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser Thr Gly Lys 
            100                 105                 110         


Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu Glu Pro Gly 
        115                 120                 125             


Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu Arg Leu Trp 
    130                 135                 140                 


Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu Arg Pro Leu 
145                 150                 155                 160 


Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg Ala Asn His 
                165                 170                 175     


Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu Val Asn Gly 
            180                 185                 190         


Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu Asp Val Glu 
        195                 200                 205             


His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu His Ala Tyr 
    210                 215                 220                 


Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile Ser Pro Ile 
225                 230                 235                 240 


Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly Arg Phe Trp 
                245                 250                 255     


Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys Pro Asn Ile 
            260                 265                 270         


Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala Gln Arg Ile 
        275                 280                 285             


Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu Pro Asn Met 
    290                 295                 300                 


Thr Gln Gly Phe Trp Glu Asn Ser Met Leu Thr Asp Pro Gly Asn Val 
305                 310                 315                 320 


Gln Lys Ala Val Cys His Pro Thr Ala Trp Asp Leu Gly Lys Gly Asp 
                325                 330                 335     


Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp Phe Leu Thr 
            340                 345                 350         


Ala His His Glu Met Gly His Ile Gln Tyr Asp Met Ala Tyr Ala Ala 
        355                 360                 365             


Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe His Glu Ala 
    370                 375                 380                 


Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys His Leu Lys 
385                 390                 395                 400 


Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn Glu Thr Glu 
                405                 410                 415     


Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly Thr Leu Pro 
            420                 425                 430         


Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe Lys Gly Glu 
        435                 440                 445             


Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met Lys Arg Glu 
    450                 455                 460                 


Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr Tyr Cys Asp 
465                 470                 475                 480 


Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe Ile Arg Tyr 
                485                 490                 495     


Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala Leu Cys Gln 
            500                 505                 510         


Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile Ser Asn Ser 
        515                 520                 525             


Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu Gly Lys Ser 
    530                 535                 540                 


Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala Lys Asn Met 
545                 550                 555                 560 


Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe Thr Trp Leu 
                565                 570                 575     


Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr Asp Trp Ser 
            580                 585                 590         


Pro Tyr Ala 
        595 


<210>  163
<211>  595
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ACE2 mutant, Ala insertion at #33

<400>  163

Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Lys Phe Ala Asn His Glu 
1               5                   10                  15      


Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ser Trp Asn Tyr Asn 
            20                  25                  30          


Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn Ala Gly Asp 
        35                  40                  45              


Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Leu Ala Gln Met Tyr 
    50                  55                  60                  


Pro Leu Gln Glu Ile Gln Asn Leu Thr Val Lys Leu Gln Leu Gln Ala 
65                  70                  75                  80  


Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys Ser Lys Arg 
                85                  90                  95      


Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser Thr Gly Lys 
            100                 105                 110         


Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu Glu Pro Gly 
        115                 120                 125             


Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu Arg Leu Trp 
    130                 135                 140                 


Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu Arg Pro Leu 
145                 150                 155                 160 


Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg Ala Asn His 
                165                 170                 175     


Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu Val Asn Gly 
            180                 185                 190         


Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu Asp Val Glu 
        195                 200                 205             


His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu His Ala Tyr 
    210                 215                 220                 


Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile Ser Pro Ile 
225                 230                 235                 240 


Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly Arg Phe Trp 
                245                 250                 255     


Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys Pro Asn Ile 
            260                 265                 270         


Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala Gln Arg Ile 
        275                 280                 285             


Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu Pro Asn Met 
    290                 295                 300                 


Thr Gln Gly Phe Trp Glu Asn Ser Met Leu Thr Asp Pro Gly Asn Val 
305                 310                 315                 320 


Gln Lys Ala Val Cys His Pro Thr Ala Trp Asp Leu Gly Lys Gly Asp 
                325                 330                 335     


Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp Phe Leu Thr 
            340                 345                 350         


Ala His His Glu Met Gly His Ile Gln Tyr Asp Met Ala Tyr Ala Ala 
        355                 360                 365             


Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe His Glu Ala 
    370                 375                 380                 


Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys His Leu Lys 
385                 390                 395                 400 


Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn Glu Thr Glu 
                405                 410                 415     


Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly Thr Leu Pro 
            420                 425                 430         


Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe Lys Gly Glu 
        435                 440                 445             


Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met Lys Arg Glu 
    450                 455                 460                 


Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr Tyr Cys Asp 
465                 470                 475                 480 


Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe Ile Arg Tyr 
                485                 490                 495     


Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala Leu Cys Gln 
            500                 505                 510         


Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile Ser Asn Ser 
        515                 520                 525             


Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu Gly Lys Ser 
    530                 535                 540                 


Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala Lys Asn Met 
545                 550                 555                 560 


Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe Thr Trp Leu 
                565                 570                 575     


Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr Asp Trp Ser 
            580                 585                 590         


Pro Tyr Ala 
        595 


<210>  164
<211>  595
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ACE2 mutant, Ala insertion at #34

<400>  164

Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Lys Phe Asn Ala His Glu 
1               5                   10                  15      


Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ser Trp Asn Tyr Asn 
            20                  25                  30          


Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn Ala Gly Asp 
        35                  40                  45              


Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Leu Ala Gln Met Tyr 
    50                  55                  60                  


Pro Leu Gln Glu Ile Gln Asn Leu Thr Val Lys Leu Gln Leu Gln Ala 
65                  70                  75                  80  


Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys Ser Lys Arg 
                85                  90                  95      


Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser Thr Gly Lys 
            100                 105                 110         


Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu Glu Pro Gly 
        115                 120                 125             


Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu Arg Leu Trp 
    130                 135                 140                 


Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu Arg Pro Leu 
145                 150                 155                 160 


Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg Ala Asn His 
                165                 170                 175     


Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu Val Asn Gly 
            180                 185                 190         


Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu Asp Val Glu 
        195                 200                 205             


His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu His Ala Tyr 
    210                 215                 220                 


Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile Ser Pro Ile 
225                 230                 235                 240 


Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly Arg Phe Trp 
                245                 250                 255     


Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys Pro Asn Ile 
            260                 265                 270         


Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala Gln Arg Ile 
        275                 280                 285             


Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu Pro Asn Met 
    290                 295                 300                 


Thr Gln Gly Phe Trp Glu Asn Ser Met Leu Thr Asp Pro Gly Asn Val 
305                 310                 315                 320 


Gln Lys Ala Val Cys His Pro Thr Ala Trp Asp Leu Gly Lys Gly Asp 
                325                 330                 335     


Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp Phe Leu Thr 
            340                 345                 350         


Ala His His Glu Met Gly His Ile Gln Tyr Asp Met Ala Tyr Ala Ala 
        355                 360                 365             


Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe His Glu Ala 
    370                 375                 380                 


Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys His Leu Lys 
385                 390                 395                 400 


Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn Glu Thr Glu 
                405                 410                 415     


Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly Thr Leu Pro 
            420                 425                 430         


Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe Lys Gly Glu 
        435                 440                 445             


Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met Lys Arg Glu 
    450                 455                 460                 


Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr Tyr Cys Asp 
465                 470                 475                 480 


Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe Ile Arg Tyr 
                485                 490                 495     


Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala Leu Cys Gln 
            500                 505                 510         


Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile Ser Asn Ser 
        515                 520                 525             


Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu Gly Lys Ser 
    530                 535                 540                 


Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala Lys Asn Met 
545                 550                 555                 560 


Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe Thr Trp Leu 
                565                 570                 575     


Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr Asp Trp Ser 
            580                 585                 590         


Pro Tyr Ala 
        595 


<210>  165
<211>  595
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ACE2 mutant, Ala insertion at #35

<400>  165

Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Lys Phe Asn His Ala Glu 
1               5                   10                  15      


Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ser Trp Asn Tyr Asn 
            20                  25                  30          


Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn Ala Gly Asp 
        35                  40                  45              


Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Leu Ala Gln Met Tyr 
    50                  55                  60                  


Pro Leu Gln Glu Ile Gln Asn Leu Thr Val Lys Leu Gln Leu Gln Ala 
65                  70                  75                  80  


Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys Ser Lys Arg 
                85                  90                  95      


Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser Thr Gly Lys 
            100                 105                 110         


Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu Glu Pro Gly 
        115                 120                 125             


Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu Arg Leu Trp 
    130                 135                 140                 


Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu Arg Pro Leu 
145                 150                 155                 160 


Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg Ala Asn His 
                165                 170                 175     


Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu Val Asn Gly 
            180                 185                 190         


Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu Asp Val Glu 
        195                 200                 205             


His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu His Ala Tyr 
    210                 215                 220                 


Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile Ser Pro Ile 
225                 230                 235                 240 


Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly Arg Phe Trp 
                245                 250                 255     


Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys Pro Asn Ile 
            260                 265                 270         


Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala Gln Arg Ile 
        275                 280                 285             


Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu Pro Asn Met 
    290                 295                 300                 


Thr Gln Gly Phe Trp Glu Asn Ser Met Leu Thr Asp Pro Gly Asn Val 
305                 310                 315                 320 


Gln Lys Ala Val Cys His Pro Thr Ala Trp Asp Leu Gly Lys Gly Asp 
                325                 330                 335     


Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp Phe Leu Thr 
            340                 345                 350         


Ala His His Glu Met Gly His Ile Gln Tyr Asp Met Ala Tyr Ala Ala 
        355                 360                 365             


Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe His Glu Ala 
    370                 375                 380                 


Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys His Leu Lys 
385                 390                 395                 400 


Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn Glu Thr Glu 
                405                 410                 415     


Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly Thr Leu Pro 
            420                 425                 430         


Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe Lys Gly Glu 
        435                 440                 445             


Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met Lys Arg Glu 
    450                 455                 460                 


Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr Tyr Cys Asp 
465                 470                 475                 480 


Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe Ile Arg Tyr 
                485                 490                 495     


Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala Leu Cys Gln 
            500                 505                 510         


Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile Ser Asn Ser 
        515                 520                 525             


Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu Gly Lys Ser 
    530                 535                 540                 


Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala Lys Asn Met 
545                 550                 555                 560 


Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe Thr Trp Leu 
                565                 570                 575     


Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr Asp Trp Ser 
            580                 585                 590         


Pro Tyr Ala 
        595 


<210>  166
<211>  595
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ACE2 mutant, Ala insertion at #36

<400>  166

Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Lys Phe Asn His Glu Ala 
1               5                   10                  15      


Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ser Trp Asn Tyr Asn 
            20                  25                  30          


Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn Ala Gly Asp 
        35                  40                  45              


Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Leu Ala Gln Met Tyr 
    50                  55                  60                  


Pro Leu Gln Glu Ile Gln Asn Leu Thr Val Lys Leu Gln Leu Gln Ala 
65                  70                  75                  80  


Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys Ser Lys Arg 
                85                  90                  95      


Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser Thr Gly Lys 
            100                 105                 110         


Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu Glu Pro Gly 
        115                 120                 125             


Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu Arg Leu Trp 
    130                 135                 140                 


Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu Arg Pro Leu 
145                 150                 155                 160 


Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg Ala Asn His 
                165                 170                 175     


Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu Val Asn Gly 
            180                 185                 190         


Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu Asp Val Glu 
        195                 200                 205             


His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu His Ala Tyr 
    210                 215                 220                 


Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile Ser Pro Ile 
225                 230                 235                 240 


Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly Arg Phe Trp 
                245                 250                 255     


Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys Pro Asn Ile 
            260                 265                 270         


Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala Gln Arg Ile 
        275                 280                 285             


Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu Pro Asn Met 
    290                 295                 300                 


Thr Gln Gly Phe Trp Glu Asn Ser Met Leu Thr Asp Pro Gly Asn Val 
305                 310                 315                 320 


Gln Lys Ala Val Cys His Pro Thr Ala Trp Asp Leu Gly Lys Gly Asp 
                325                 330                 335     


Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp Phe Leu Thr 
            340                 345                 350         


Ala His His Glu Met Gly His Ile Gln Tyr Asp Met Ala Tyr Ala Ala 
        355                 360                 365             


Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe His Glu Ala 
    370                 375                 380                 


Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys His Leu Lys 
385                 390                 395                 400 


Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn Glu Thr Glu 
                405                 410                 415     


Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly Thr Leu Pro 
            420                 425                 430         


Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe Lys Gly Glu 
        435                 440                 445             


Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met Lys Arg Glu 
    450                 455                 460                 


Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr Tyr Cys Asp 
465                 470                 475                 480 


Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe Ile Arg Tyr 
                485                 490                 495     


Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala Leu Cys Gln 
            500                 505                 510         


Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile Ser Asn Ser 
        515                 520                 525             


Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu Gly Lys Ser 
    530                 535                 540                 


Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala Lys Asn Met 
545                 550                 555                 560 


Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe Thr Trp Leu 
                565                 570                 575     


Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr Asp Trp Ser 
            580                 585                 590         


Pro Tyr Ala 
        595 


<210>  167
<211>  595
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ACE2 mutant, Ala insertion at #38

<400>  167

Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Lys Phe Asn His Glu Ala 
1               5                   10                  15      


Glu Ala Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ser Trp Asn Tyr Asn 
            20                  25                  30          


Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn Ala Gly Asp 
        35                  40                  45              


Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Leu Ala Gln Met Tyr 
    50                  55                  60                  


Pro Leu Gln Glu Ile Gln Asn Leu Thr Val Lys Leu Gln Leu Gln Ala 
65                  70                  75                  80  


Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys Ser Lys Arg 
                85                  90                  95      


Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser Thr Gly Lys 
            100                 105                 110         


Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu Glu Pro Gly 
        115                 120                 125             


Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu Arg Leu Trp 
    130                 135                 140                 


Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu Arg Pro Leu 
145                 150                 155                 160 


Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg Ala Asn His 
                165                 170                 175     


Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu Val Asn Gly 
            180                 185                 190         


Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu Asp Val Glu 
        195                 200                 205             


His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu His Ala Tyr 
    210                 215                 220                 


Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile Ser Pro Ile 
225                 230                 235                 240 


Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly Arg Phe Trp 
                245                 250                 255     


Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys Pro Asn Ile 
            260                 265                 270         


Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala Gln Arg Ile 
        275                 280                 285             


Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu Pro Asn Met 
    290                 295                 300                 


Thr Gln Gly Phe Trp Glu Asn Ser Met Leu Thr Asp Pro Gly Asn Val 
305                 310                 315                 320 


Gln Lys Ala Val Cys His Pro Thr Ala Trp Asp Leu Gly Lys Gly Asp 
                325                 330                 335     


Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp Phe Leu Thr 
            340                 345                 350         


Ala His His Glu Met Gly His Ile Gln Tyr Asp Met Ala Tyr Ala Ala 
        355                 360                 365             


Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe His Glu Ala 
    370                 375                 380                 


Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys His Leu Lys 
385                 390                 395                 400 


Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn Glu Thr Glu 
                405                 410                 415     


Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly Thr Leu Pro 
            420                 425                 430         


Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe Lys Gly Glu 
        435                 440                 445             


Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met Lys Arg Glu 
    450                 455                 460                 


Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr Tyr Cys Asp 
465                 470                 475                 480 


Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe Ile Arg Tyr 
                485                 490                 495     


Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala Leu Cys Gln 
            500                 505                 510         


Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile Ser Asn Ser 
        515                 520                 525             


Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu Gly Lys Ser 
    530                 535                 540                 


Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala Lys Asn Met 
545                 550                 555                 560 


Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe Thr Trp Leu 
                565                 570                 575     


Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr Asp Trp Ser 
            580                 585                 590         


Pro Tyr Ala 
        595 


<210>  168
<211>  3596
<212>  DNA
<213>  Homo sapiens

<400>  168
ggcactcata catacactct ggcaatgagg acactgagct cgcttctgaa atttgacaag       60

ataaccacta aaatctcttt gaattctatg ttgttgtgat cccatggcta cagaggatca      120

ggagttgaca tagatactct ttggatttca taccatgtgg aggctttctt acttccacgt      180

gaccttgact gagttttgaa tagcgcccaa cccaagttca aaggctgata agagagaaaa      240

tctcatgagg aggttttagt ctagggaaag tcattcagtg gatgtgatct tggctcacag      300

gggacgatgt caagctcttc ctggctcctt ctcagccttg ttgctgtaac tgctgctcag      360

tccaccattg aggaacaggc caagacattt ttggacaagt ttaaccacga agccgaagac      420

ctgttctatc aaagttcact tgcttcttgg aattataaca ccaatattac tgaagagaat      480

gtccaaaaca tgaataatgc tggggacaaa tggtctgcct ttttaaagga acagtccaca      540

cttgcccaaa tgtatccact acaagaaatt cagaatctca cagtcaagct tcagctgcag      600

gctcttcagc aaaatgggtc ttcagtgctc tcagaagaca agagcaaacg gttgaacaca      660

attctaaata caatgagcac catctacagt actggaaaag tttgtaaccc agataatcca      720

caagaatgct tattacttga accaggtttg aatgaaataa tggcaaacag tttagactac      780

aatgagaggc tctgggcttg ggaaagctgg agatctgagg tcggcaagca gctgaggcca      840

ttatatgaag agtatgtggt cttgaaaaat gagatggcaa gagcaaatca ttatgaggac      900

tatggggatt attggagagg agactatgaa gtaaatgggg tagatggcta tgactacagc      960

cgcggccagt tgattgaaga tgtggaacat acctttgaag agattaaacc attatatgaa     1020

catcttcatg cctatgtgag ggcaaagttg atgaatgcct atccttccta tatcagtcca     1080

attggatgcc tccctgctca tttgcttggt gatatgtggg gtagattttg gacaaatctg     1140

tactctttga cagttccctt tggacagaaa ccaaacatag atgttactga tgcaatggtg     1200

gaccaggcct gggatgcaca gagaatattc aaggaggccg agaagttctt tgtatctgtt     1260

ggtcttccta atatgactca aggattctgg gaaaattcca tgctaacgga cccaggaaat     1320

gttcagaaag cagtctgcca tcccacagct tgggacctgg ggaagggcga cttcaggatc     1380

cttatgtgca caaaggtgac aatggacgac ttcctgacag ctcatcatga gatggggcat     1440

atccagtatg atatggcata tgctgcacaa ccttttctgc taagaaatgg agctaatgaa     1500

ggattccatg aagctgttgg ggaaatcatg tcactttctg cagccacacc taagcattta     1560

aaatccattg gtcttctgtc acccgatttt caagaagaca atgaaacaga aataaacttc     1620

ctgctcaaac aagcactcac gattgttggg actctgccat ttacttacat gttagagaag     1680

tggaggtgga tggtctttaa aggggaaatt cccaaagacc agtggatgaa aaagtggtgg     1740

gagatgaagc gagagatagt tggggtggtg gaacctgtgc cccatgatga aacatactgt     1800

gaccccgcat ctctgttcca tgtttctaat gattactcat tcattcgata ttacacaagg     1860

accctttacc aattccagtt tcaagaagca ctttgtcaag cagctaaaca tgaaggccct     1920

ctgcacaaat gtgacatctc aaactctaca gaagctggac agaaactgtt caatatgctg     1980

aggcttggaa aatcagaacc ctggacccta gcattggaaa atgttgtagg agcaaagaac     2040

atgaatgtaa ggccactgct caactacttt gagcccttat ttacctggct gaaagaccag     2100

aacaagaatt cttttgtggg atggagtacc gactggagtc catatgcaga ccaaagcatc     2160

aaagtgagga taagcctaaa atcagctctt ggagataaag catatgaatg gaacgacaat     2220

gaaatgtacc tgttccgatc atctgttgca tatgctatga ggcagtactt tttaaaagta     2280

aaaaatcaga tgattctttt tggggaggag gatgtgcgag tggctaattt gaaaccaaga     2340

atctccttta atttctttgt cactgcacct aaaaatgtgt ctgatatcat tcctagaact     2400

gaagttgaaa aggccatcag gatgtcccgg agccgtatca atgatgcttt ccgtctgaat     2460

gacaacagcc tagagtttct ggggatacag ccaacacttg gacctcctaa ccagccccct     2520

gtttccatat ggctgattgt ttttggagtt gtgatgggag tgatagtggt tggcattgtc     2580

atcctgatct tcactgggat cagagatcgg aagaagaaaa ataaagcaag aagtggagaa     2640

aatccttatg cctccatcga tattagcaaa ggagaaaata atccaggatt ccaaaacact     2700

gatgatgttc agacctcctt ttagaaaaat ctatgttttt cctcttgagg tgattttgtt     2760

gtatgtaaat gttaatttca tggtatagaa aatataagat gataaagata tcattaaatg     2820

tcaaaactat gactctgttc agaaaaaaaa ttgtccaaag acaacatggc caaggagaga     2880

gcatcttcat tgacattgct ttcagtattt atttctgtct ctggatttga cttctgttct     2940

gtttcttaat aaggattttg tattagagta tattagggaa agtgtgtatt tggtctcaca     3000

ggctgttcag ggataatcta aatgtaaatg tctgttgaat ttctgaagtt gaaaacaagg     3060

atatatcatt ggagcaagtg ttggatcttg tatggaatat ggatggatca cttgtaagga     3120

cagtgcctgg gaactggtgt agctgcaagg attgagaatg gcatgcatta gctcactttc     3180

atttaatcca ttgtcaagga tgacatgctt tcttcacagt aactcagttc aagtactatg     3240

gtgatttgcc tacagtgatg tttggaatcg atcatgcttt cttcaaggtg acaggtctaa     3300

agagagaaga atccagggaa caggtagagg acattgcttt ttcacttcca aggtgcttga     3360

tcaacatctc cctgacaaca caaaactaga gccaggggcc tccgtgaact cccagagcat     3420

gcctgataga aactcatttc tactgttctc taactgtgga gtgaatggaa attccaactg     3480

tatgttcacc ctctgaagtg ggtacccagt ctcttaaatc ttttgtattt gctcacagtg     3540

tttgagcagt gctgagcaca aagcagacac tcaataaatg ctagatttac acactc         3596


<210>  169
<211>  696
<212>  DNA
<213>  Homo sapiens

<400>  169
gagcccaaat cttgtgacaa aactcacaca tgcccaccgt gcccagcacc tgaactcctg       60

gggggaccgt cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg      120

acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc      180

aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccgcg ggaggagcag      240

tacaacagca cgtaccgtgt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat      300

ggcaaggagt acaagtgcaa ggtctccaac aaagccctcc cagcccccat cgagaaaacc      360

atctccaaag ccaaagggca gccccgagaa ccacaggtgt acaccctgcc cccatcccgg      420

gaggagatga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatcccagc      480

gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct      540

cccgtgctgg actccgacgg ctccttcttc ctctatagca agctcaccgt ggacaagagc      600

aggtggcagc aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac      660

tacacgcaga agagcctctc cctgtccccg ggtaaa                                696


<210>  170
<211>  2440
<212>  DNA
<213>  Homo sapiens

<400>  170
atcctgctaa tgtgcattga aaggagagca acggggctga ggccgtgtca gcacgatgga       60

ccccaaacag accaccctcc tgtgtcttgg ggactttccc atgcctttca tatctgccaa      120

atcgagtcct gtgattccct tggatggatc tgtgaaaatc cagtgccagg ccattcgtga      180

agcttacctg acccagctga tgatcataaa aaactccacg taccgagaga taggcagaag      240

actgaagttt tggaatgaga ctgatcctga gttcgtcatt gaccacatgg acgcaaacaa      300

ggcagggcgc tatcagtgcc aatataggat agggcactac aggttccggt acagtgacac      360

cctggagctg gtagtgacag gcttgtatgg caaacccttc ctctctgcag atcggggtct      420

ggtgttgatg ccaggagaga atatttccct cacgtgcagc tcagcacaca tcccatttga      480

tagattttca ctggccaagg agggagaact ttctctgcca cagcaccaaa gtggggaaca      540

cccggccaac ttctctttgg gtcctgtgga cctcaatgtc tcagggatct acaggtgcta      600

cggttggtac aacaggagcc cctacctgtg gtccttcccc agtaatgcct tggagcttgt      660

ggtcacagac tccatccacc aagattacac gacgcagaac ttgatccgca tggccgtggc      720

aggactggtc ctcgtggctc tcttggccat actggttgaa aattggcaca gccatacggc      780

actgaacaag gaagcctcgg cagatgtggc tgaaccgagc tggagccaac agatgtgtca      840

gccaggattg acctttgcac gaacaccaag tgtctgcaag taaacacctg gaggtgaagg      900

cagagaggag ccaggactgt ggagtccgac aaagctactt gaaggacaca agagagaaaa      960

gctcactaag aagcttgaat ctactttttt ttttttttga gacagagtct ggctctgtca     1020

cccaggctgg agtgcagtgg agcaatctcg gctcattgaa cctcttgggt tcaagtgatt     1080

cttgtgcctc agcctcccaa gtagctggaa ttacaggcac ataccactgc acccagctaa     1140

tttttgtatt tttagtagag atggggtttc actgtgttgg ccaggctggt ctcgaactcc     1200

tgacctcagg tgatccaccc accttggcct cccaaagtgc tgagattata ggcatgagcc     1260

accacgcctg gccagatgca tgttcaaacc aatcaaatgg tgttttctta tgcaggactg     1320

atcgatttgc acccaccttt ctgcacataa gttatggttt tccatcttat ctgtcttctg     1380

attttttata tcctgtttaa tttcttcctt cattgttctt ctcttttttt atttatttta     1440

tttattttta tttttatttt tatttgagac agagtctcac tctgttgccc aggctggagt     1500

gcagtggcac gatctcggct cactgcaacc tctgcctcct gggttcaagt gattctcctg     1560

cctcggcctc ccaagtagct gggattgcag gctcccacca tcacgcccag ctacttttac     1620

agtattttta gtagagacgg ggtttcatca cattggccaa gctggtctca aacttctgac     1680

ctcgtgatct gcccgcctcg gcctcccaaa gtgctgggat tacagatgtg agccactgcg     1740

cccagccttc tttttatatt tttaaatgtg tcttccccaa atataaatgg ttggtaagca     1800

tgccaaatat attcaataac ccccctcctt tatttttttt tgttgaagtg aggctctccc     1860

tatgttgcct aagctggtct tgaactcctg gtctcaagca atcctcctac ctcagcctcc     1920

tgctgtgttc atctacaaat tgataagagt gaaagtcata atcctacagg aggattaccc     1980

tatttatttc acaaacccta tttctaccgg attttcatac aaggaataca ggcatgtgtt     2040

tcacctcatt aatttatttt ttcacttagt tttgatgata ttcacatata ttatcaagtg     2100

tgcaaacatt aaattcttgt gtacaaaact caaatggtct tccaaataat tccccattct     2160

tttttcttat aaactttcac agctttaccc ttgacagact ttactcaagg aaatctaagt     2220

tggtcatatg tggctctttc actgattgct atttacttca ttgtccagta gcttatgtat     2280

gaaaatataa ttataaaatg taagggtcct acttccagtg aaactgaagg gacttaggcc     2340

cacttttatc ctttactgag agcttatctc tacttgataa aatttctact gtattcttgg     2400

cttaactcag gtcctgtgat taaaaaaaaa atgcaaagta                           2440


<210>  171
<211>  729
<212>  DNA
<213>  Homo sapiens

<400>  171
ccggccatgg ccgaggtgca gctgttggag tctgggggag gcttggtaca gcctgggggg       60

tccctgagac tctcctgtgc agcctctgga ttcaccttta gcagctatgc catgagctgg      120

gtccgccagg ctccagggaa ggggctggag tgggtctcaa ctatttctag taatggtggt      180

tatacatatt acgcagactc cgtgaagggc aggttcacca tctccagaga caattccaag      240

aacacgctgt atctgcaaat gaacagcctg agagccgagg acacggccgt atattactgt      300

gcgaaagctt attctgcttt tgactactgg ggccagggaa ccctggtcac cgtctcgagc      360

ggtggaggcg gttcaggcgg aggtggcagc ggcggtggcg ggtcgacgga catccagatg      420

acccagtctc catcctccct gtctgcatct gtaggagaca gagtcaccat cacttgccgg      480

gcaagtcaga gcattagcag ctatttaaat tggtatcagc agaaaccagg gaaagcccct      540

aagctcctga tctatactgc atccactttg caaagtgggg tcccgtcaag gttcagtggc      600

agtggatctg ggacagattt cactctcacc atcagcagtc tgcaacctga agattttgca      660

acttactact gtcaacagac ttctgctaat cctggtacgt tcggccaagg gaccaaggtg      720

gaaatcaaa                                                              729


<210>  172
<211>  321
<212>  DNA
<213>  Homo sapiens

<400>  172
gacatccagt tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc aggcgagtca ggacattagc aactatttaa attggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctacgat gcatccaatt tggaaacagg ggtcccatca      180

aggttcagtg gaagtggatc tgggacagat tttactttca ccatcagcag tctgcaacct      240

gaagattttg caacttacta ctgtcaacag agttacagtt caccttggac gttcggccaa      300

gggaccaagg tggaaatcaa a                                                321


<210>  173
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-Spike Group 21, CDR-H1

<400>  173

Ser Ser Tyr Ala Met Ser 
1               5       


<210>  174
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-Spike Group 21, CDR-H2

<400>  174

Ala Ile Ser Gly Ser Gly Gly Ser Thr Asn 
1               5                   10  


<210>  175
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-Spike Group 21, CDR-H3

<400>  175

Asp Leu Trp Gly Leu Ala Phe Ala 
1               5               


<210>  176
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-Spike Group 21, CDR-L3

<400>  176

Asp Ser Ser Asn Pro Trp 
1               5       


<210>  177
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-Spike Group 22, CDR-H1

<400>  177

Ser Ser Tyr Ala Met Ser 
1               5       


<210>  178
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-Spike Group 22, CDR-H2

<400>  178

Ser Ile Ser Gly Ser Gly Gly Ser Thr Asp 
1               5                   10  


<210>  179
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-Spike Group 22, CDR-H3

<400>  179

Asp Leu Trp Gly Leu Ala Met Ala 
1               5               


<210>  180
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-Spike Group 22, CDR-L3

<400>  180

Asp Asn Asn Val Pro Leu 
1               5       


<210>  181
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-Spike Group 23, CDR-H1

<400>  181

Ser Ser Tyr Ala Met His 
1               5       


<210>  182
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-Spike Group 23, CDR-H2

<400>  182

Ala Ile Ser Trp Ser Gly Arg Ser Thr Tyr 
1               5                   10  


<210>  183
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-Spike Group 23, CDR-H3

<400>  183

Asp Leu Ser Ser Asn Trp Gly Ala Gly 
1               5                   


<210>  184
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-Spike Group 23, CDR-L3

<400>  184

Ser Ala Asp Thr Pro Phe 
1               5       


<210>  185
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-Spike Group 24, CDR-H1

<400>  185

Ser Ser Tyr Ala Met His 
1               5       


<210>  186
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-Spike Group 24, CDR-H2

<400>  186

Ala Ile Ser Trp Ser Gly Arg Ser Thr Tyr 
1               5                   10  


<210>  187
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-Spike Group 24, CDR-H3

<400>  187

Asp Leu Ser Ser Asn Trp Gly Ser Gly 
1               5                   


<210>  188
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-Spike Group 24, CDR-L3

<400>  188

Ser Ala Asp Thr Pro Phe 
1               5       


<210>  189
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-Spike Group 25, CDR-H1

<400>  189

Ser Ser Tyr Ala Met His 
1               5       


<210>  190
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-Spike Group 25, CDR-H2

<400>  190

Ile Ile Ser Gly Ser Gly Gly Ser Thr Ser 
1               5                   10  


<210>  191
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-Spike Group 25, CDR-H3

<400>  191

Asp Leu Cys Asp Cys Phe Ala Val Ala 
1               5                   


<210>  192
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-Spike Group 25, CDR-L3

<400>  192

Trp Ala Ala Arg Pro Leu 
1               5       


<210>  193
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-Spike Group 26, CDR-H1

<400>  193

Ser Ala Tyr Ala Met His 
1               5       


<210>  194
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-Spike Group 26, CDR-H2

<400>  194

Ala Ile Trp Gly Ser Gly Gly Ser Thr Tyr 
1               5                   10  


<210>  195
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-Spike Group 26, CDR-H3

<400>  195

Asp Leu Trp Met Ala Met Trp Phe Gly 
1               5                   


<210>  196
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-Spike Group 26, CDR-L3

<400>  196

Arg Ser Thr Tyr Pro Leu 
1               5       


<210>  197
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-Spike Group 27, CDR-H1

<400>  197

Ser Ser Tyr Ala Met Ser 
1               5       


<210>  198
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-Spike Group 27, CDR-H2

<400>  198

Ala Ile Ser Gly Ser Gly Gly Ser Thr Ser 
1               5                   10  


<210>  199
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-Spike Group 27, CDR-H3

<400>  199

Asp Leu Ile Tyr Asp Thr Val Trp Trp Gly 
1               5                   10  


<210>  200
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-Spike Group 27, CDR-L3

<400>  200

Asp Thr Asn Val Pro Tyr 
1               5       


<210>  201
<211>  805
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R273 mutant ACE2


<220>
<221>  MUTAGEN
<222>  (273)..(273)
<223>  The sequence here can be Ala, Asn, Asp, Cys, Gln, Glu, Gly, His, 
       Ile, Lys, Leu, Met, Phe, Pro, Ser, Thr, Trp, Tyr, or Val.

<400>  201

Met Ser Ser Ser Ser Trp Leu Leu Leu Ser Leu Val Ala Val Thr Ala 
1               5                   10                  15      


Ala Gln Ser Thr Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Lys Phe 
            20                  25                  30          


Asn His Glu Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ser Trp 
        35                  40                  45              


Asn Tyr Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn 
    50                  55                  60                  


Ala Gly Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Leu Ala 
65                  70                  75                  80  


Gln Met Tyr Pro Leu Gln Glu Ile Gln Asn Leu Thr Val Lys Leu Gln 
                85                  90                  95      


Leu Gln Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys 
            100                 105                 110         


Ser Lys Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser 
        115                 120                 125             


Thr Gly Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu 
    130                 135                 140                 


Glu Pro Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu 
145                 150                 155                 160 


Arg Leu Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu 
                165                 170                 175     


Arg Pro Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg 
            180                 185                 190         


Ala Asn His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu 
        195                 200                 205             


Val Asn Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu 
    210                 215                 220                 


Asp Val Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu 
225                 230                 235                 240 


His Ala Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile 
                245                 250                 255     


Ser Pro Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly 
            260                 265                 270         


Xaa Phe Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys 
        275                 280                 285             


Pro Asn Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala 
    290                 295                 300                 


Gln Arg Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu 
305                 310                 315                 320 


Pro Asn Met Thr Gln Gly Phe Trp Glu Asn Ser Met Leu Thr Asp Pro 
                325                 330                 335     


Gly Asn Val Gln Lys Ala Val Cys His Pro Thr Ala Trp Asp Leu Gly 
            340                 345                 350         


Lys Gly Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp 
        355                 360                 365             


Phe Leu Thr Ala His His Glu Met Gly His Ile Gln Tyr Asp Met Ala 
    370                 375                 380                 


Tyr Ala Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe 
385                 390                 395                 400 


His Glu Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys 
                405                 410                 415     


His Leu Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn 
            420                 425                 430         


Glu Thr Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly 
        435                 440                 445             


Thr Leu Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe 
    450                 455                 460                 


Lys Gly Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met 
465                 470                 475                 480 


Lys Arg Glu Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr 
                485                 490                 495     


Tyr Cys Asp Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe 
            500                 505                 510         


Ile Arg Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala 
        515                 520                 525             


Leu Cys Gln Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile 
    530                 535                 540                 


Ser Asn Ser Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu 
545                 550                 555                 560 


Gly Lys Ser Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala 
                565                 570                 575     


Lys Asn Met Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe 
            580                 585                 590         


Thr Trp Leu Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr 
        595                 600                 605             


Asp Trp Ser Pro Tyr Ala Asp Gln Ser Ile Lys Val Arg Ile Ser Leu 
    610                 615                 620                 


Lys Ser Ala Leu Gly Asp Lys Ala Tyr Glu Trp Asn Asp Asn Glu Met 
625                 630                 635                 640 


Tyr Leu Phe Arg Ser Ser Val Ala Tyr Ala Met Arg Gln Tyr Phe Leu 
                645                 650                 655     


Lys Val Lys Asn Gln Met Ile Leu Phe Gly Glu Glu Asp Val Arg Val 
            660                 665                 670         


Ala Asn Leu Lys Pro Arg Ile Ser Phe Asn Phe Phe Val Thr Ala Pro 
        675                 680                 685             


Lys Asn Val Ser Asp Ile Ile Pro Arg Thr Glu Val Glu Lys Ala Ile 
    690                 695                 700                 


Arg Met Ser Arg Ser Arg Ile Asn Asp Ala Phe Arg Leu Asn Asp Asn 
705                 710                 715                 720 


Ser Leu Glu Phe Leu Gly Ile Gln Pro Thr Leu Gly Pro Pro Asn Gln 
                725                 730                 735     


Pro Pro Val Ser Ile Trp Leu Ile Val Phe Gly Val Val Met Gly Val 
            740                 745                 750         


Ile Val Val Gly Ile Val Ile Leu Ile Phe Thr Gly Ile Arg Asp Arg 
        755                 760                 765             


Lys Lys Lys Asn Lys Ala Arg Ser Gly Glu Asn Pro Tyr Ala Ser Ile 
    770                 775                 780                 


Asp Ile Ser Lys Gly Glu Asn Asn Pro Gly Phe Gln Asn Thr Asp Asp 
785                 790                 795                 800 


Val Gln Thr Ser Phe 
                805 


<210>  202
<211>  805
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H345 mutant ACE2


<220>
<221>  MUTAGEN
<222>  (345)..(345)
<223>  The sequence here can be Ala, Arg, Asn, Asp, Cys, Gln, Glu, Gly, 
       Ile, Lys, Leu, Met, Phe, Pro, Ser, Thr, Trp, Tyr, or Val.

<400>  202

Met Ser Ser Ser Ser Trp Leu Leu Leu Ser Leu Val Ala Val Thr Ala 
1               5                   10                  15      


Ala Gln Ser Thr Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Lys Phe 
            20                  25                  30          


Asn His Glu Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ser Trp 
        35                  40                  45              


Asn Tyr Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn 
    50                  55                  60                  


Ala Gly Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Leu Ala 
65                  70                  75                  80  


Gln Met Tyr Pro Leu Gln Glu Ile Gln Asn Leu Thr Val Lys Leu Gln 
                85                  90                  95      


Leu Gln Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys 
            100                 105                 110         


Ser Lys Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser 
        115                 120                 125             


Thr Gly Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu 
    130                 135                 140                 


Glu Pro Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu 
145                 150                 155                 160 


Arg Leu Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu 
                165                 170                 175     


Arg Pro Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg 
            180                 185                 190         


Ala Asn His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu 
        195                 200                 205             


Val Asn Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu 
    210                 215                 220                 


Asp Val Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu 
225                 230                 235                 240 


His Ala Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile 
                245                 250                 255     


Ser Pro Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly 
            260                 265                 270         


Arg Phe Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys 
        275                 280                 285             


Pro Asn Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala 
    290                 295                 300                 


Gln Arg Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu 
305                 310                 315                 320 


Pro Asn Met Thr Gln Gly Phe Trp Glu Asn Ser Met Leu Thr Asp Pro 
                325                 330                 335     


Gly Asn Val Gln Lys Ala Val Cys Xaa Pro Thr Ala Trp Asp Leu Gly 
            340                 345                 350         


Lys Gly Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp 
        355                 360                 365             


Phe Leu Thr Ala His His Glu Met Gly His Ile Gln Tyr Asp Met Ala 
    370                 375                 380                 


Tyr Ala Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe 
385                 390                 395                 400 


His Glu Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys 
                405                 410                 415     


His Leu Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn 
            420                 425                 430         


Glu Thr Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly 
        435                 440                 445             


Thr Leu Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe 
    450                 455                 460                 


Lys Gly Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met 
465                 470                 475                 480 


Lys Arg Glu Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr 
                485                 490                 495     


Tyr Cys Asp Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe 
            500                 505                 510         


Ile Arg Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala 
        515                 520                 525             


Leu Cys Gln Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile 
    530                 535                 540                 


Ser Asn Ser Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu 
545                 550                 555                 560 


Gly Lys Ser Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala 
                565                 570                 575     


Lys Asn Met Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe 
            580                 585                 590         


Thr Trp Leu Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr 
        595                 600                 605             


Asp Trp Ser Pro Tyr Ala Asp Gln Ser Ile Lys Val Arg Ile Ser Leu 
    610                 615                 620                 


Lys Ser Ala Leu Gly Asp Lys Ala Tyr Glu Trp Asn Asp Asn Glu Met 
625                 630                 635                 640 


Tyr Leu Phe Arg Ser Ser Val Ala Tyr Ala Met Arg Gln Tyr Phe Leu 
                645                 650                 655     


Lys Val Lys Asn Gln Met Ile Leu Phe Gly Glu Glu Asp Val Arg Val 
            660                 665                 670         


Ala Asn Leu Lys Pro Arg Ile Ser Phe Asn Phe Phe Val Thr Ala Pro 
        675                 680                 685             


Lys Asn Val Ser Asp Ile Ile Pro Arg Thr Glu Val Glu Lys Ala Ile 
    690                 695                 700                 


Arg Met Ser Arg Ser Arg Ile Asn Asp Ala Phe Arg Leu Asn Asp Asn 
705                 710                 715                 720 


Ser Leu Glu Phe Leu Gly Ile Gln Pro Thr Leu Gly Pro Pro Asn Gln 
                725                 730                 735     


Pro Pro Val Ser Ile Trp Leu Ile Val Phe Gly Val Val Met Gly Val 
            740                 745                 750         


Ile Val Val Gly Ile Val Ile Leu Ile Phe Thr Gly Ile Arg Asp Arg 
        755                 760                 765             


Lys Lys Lys Asn Lys Ala Arg Ser Gly Glu Asn Pro Tyr Ala Ser Ile 
    770                 775                 780                 


Asp Ile Ser Lys Gly Glu Asn Asn Pro Gly Phe Gln Asn Thr Asp Asp 
785                 790                 795                 800 


Val Gln Thr Ser Phe 
                805 


<210>  203
<211>  805
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H374 mutant ACE2


<220>
<221>  MUTAGEN
<222>  (374)..(374)
<223>  The sequence here can be Ala, Arg, Asn, Asp, Cys, Gln, Glu, Gly, 
       Ile, Lys, Leu, Met, Phe, Pro, Ser, Thr, Trp, Tyr, or Val.

<400>  203

Met Ser Ser Ser Ser Trp Leu Leu Leu Ser Leu Val Ala Val Thr Ala 
1               5                   10                  15      


Ala Gln Ser Thr Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Lys Phe 
            20                  25                  30          


Asn His Glu Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ser Trp 
        35                  40                  45              


Asn Tyr Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn 
    50                  55                  60                  


Ala Gly Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Leu Ala 
65                  70                  75                  80  


Gln Met Tyr Pro Leu Gln Glu Ile Gln Asn Leu Thr Val Lys Leu Gln 
                85                  90                  95      


Leu Gln Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys 
            100                 105                 110         


Ser Lys Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser 
        115                 120                 125             


Thr Gly Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu 
    130                 135                 140                 


Glu Pro Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu 
145                 150                 155                 160 


Arg Leu Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu 
                165                 170                 175     


Arg Pro Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg 
            180                 185                 190         


Ala Asn His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu 
        195                 200                 205             


Val Asn Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu 
    210                 215                 220                 


Asp Val Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu 
225                 230                 235                 240 


His Ala Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile 
                245                 250                 255     


Ser Pro Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly 
            260                 265                 270         


Arg Phe Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys 
        275                 280                 285             


Pro Asn Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala 
    290                 295                 300                 


Gln Arg Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu 
305                 310                 315                 320 


Pro Asn Met Thr Gln Gly Phe Trp Glu Asn Ser Met Leu Thr Asp Pro 
                325                 330                 335     


Gly Asn Val Gln Lys Ala Val Cys His Pro Thr Ala Trp Asp Leu Gly 
            340                 345                 350         


Lys Gly Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp 
        355                 360                 365             


Phe Leu Thr Ala His Xaa Glu Met Gly His Ile Gln Tyr Asp Met Ala 
    370                 375                 380                 


Tyr Ala Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe 
385                 390                 395                 400 


His Glu Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys 
                405                 410                 415     


His Leu Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn 
            420                 425                 430         


Glu Thr Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly 
        435                 440                 445             


Thr Leu Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe 
    450                 455                 460                 


Lys Gly Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met 
465                 470                 475                 480 


Lys Arg Glu Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr 
                485                 490                 495     


Tyr Cys Asp Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe 
            500                 505                 510         


Ile Arg Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala 
        515                 520                 525             


Leu Cys Gln Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile 
    530                 535                 540                 


Ser Asn Ser Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu 
545                 550                 555                 560 


Gly Lys Ser Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala 
                565                 570                 575     


Lys Asn Met Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe 
            580                 585                 590         


Thr Trp Leu Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr 
        595                 600                 605             


Asp Trp Ser Pro Tyr Ala Asp Gln Ser Ile Lys Val Arg Ile Ser Leu 
    610                 615                 620                 


Lys Ser Ala Leu Gly Asp Lys Ala Tyr Glu Trp Asn Asp Asn Glu Met 
625                 630                 635                 640 


Tyr Leu Phe Arg Ser Ser Val Ala Tyr Ala Met Arg Gln Tyr Phe Leu 
                645                 650                 655     


Lys Val Lys Asn Gln Met Ile Leu Phe Gly Glu Glu Asp Val Arg Val 
            660                 665                 670         


Ala Asn Leu Lys Pro Arg Ile Ser Phe Asn Phe Phe Val Thr Ala Pro 
        675                 680                 685             


Lys Asn Val Ser Asp Ile Ile Pro Arg Thr Glu Val Glu Lys Ala Ile 
    690                 695                 700                 


Arg Met Ser Arg Ser Arg Ile Asn Asp Ala Phe Arg Leu Asn Asp Asn 
705                 710                 715                 720 


Ser Leu Glu Phe Leu Gly Ile Gln Pro Thr Leu Gly Pro Pro Asn Gln 
                725                 730                 735     


Pro Pro Val Ser Ile Trp Leu Ile Val Phe Gly Val Val Met Gly Val 
            740                 745                 750         


Ile Val Val Gly Ile Val Ile Leu Ile Phe Thr Gly Ile Arg Asp Arg 
        755                 760                 765             


Lys Lys Lys Asn Lys Ala Arg Ser Gly Glu Asn Pro Tyr Ala Ser Ile 
    770                 775                 780                 


Asp Ile Ser Lys Gly Glu Asn Asn Pro Gly Phe Gln Asn Thr Asp Asp 
785                 790                 795                 800 


Val Gln Thr Ser Phe 
                805 


<210>  204
<211>  805
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H378 mutant ACE2


<220>
<221>  MUTAGEN
<222>  (378)..(378)
<223>  The sequence here can be Ala, Arg, Asn, Asp, Cys, Gln, Glu, Gly, 
       Ile, Lys, Leu, Met, Phe, Pro, Ser, Thr, Trp, Tyr, or Val.

<400>  204

Met Ser Ser Ser Ser Trp Leu Leu Leu Ser Leu Val Ala Val Thr Ala 
1               5                   10                  15      


Ala Gln Ser Thr Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Lys Phe 
            20                  25                  30          


Asn His Glu Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ser Trp 
        35                  40                  45              


Asn Tyr Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn 
    50                  55                  60                  


Ala Gly Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Leu Ala 
65                  70                  75                  80  


Gln Met Tyr Pro Leu Gln Glu Ile Gln Asn Leu Thr Val Lys Leu Gln 
                85                  90                  95      


Leu Gln Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys 
            100                 105                 110         


Ser Lys Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser 
        115                 120                 125             


Thr Gly Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu 
    130                 135                 140                 


Glu Pro Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu 
145                 150                 155                 160 


Arg Leu Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu 
                165                 170                 175     


Arg Pro Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg 
            180                 185                 190         


Ala Asn His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu 
        195                 200                 205             


Val Asn Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu 
    210                 215                 220                 


Asp Val Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu 
225                 230                 235                 240 


His Ala Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile 
                245                 250                 255     


Ser Pro Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly 
            260                 265                 270         


Arg Phe Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys 
        275                 280                 285             


Pro Asn Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala 
    290                 295                 300                 


Gln Arg Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu 
305                 310                 315                 320 


Pro Asn Met Thr Gln Gly Phe Trp Glu Asn Ser Met Leu Thr Asp Pro 
                325                 330                 335     


Gly Asn Val Gln Lys Ala Val Cys His Pro Thr Ala Trp Asp Leu Gly 
            340                 345                 350         


Lys Gly Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp 
        355                 360                 365             


Phe Leu Thr Ala His His Glu Met Gly Xaa Ile Gln Tyr Asp Met Ala 
    370                 375                 380                 


Tyr Ala Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe 
385                 390                 395                 400 


His Glu Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys 
                405                 410                 415     


His Leu Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn 
            420                 425                 430         


Glu Thr Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly 
        435                 440                 445             


Thr Leu Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe 
    450                 455                 460                 


Lys Gly Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met 
465                 470                 475                 480 


Lys Arg Glu Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr 
                485                 490                 495     


Tyr Cys Asp Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe 
            500                 505                 510         


Ile Arg Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala 
        515                 520                 525             


Leu Cys Gln Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile 
    530                 535                 540                 


Ser Asn Ser Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu 
545                 550                 555                 560 


Gly Lys Ser Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala 
                565                 570                 575     


Lys Asn Met Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe 
            580                 585                 590         


Thr Trp Leu Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr 
        595                 600                 605             


Asp Trp Ser Pro Tyr Ala Asp Gln Ser Ile Lys Val Arg Ile Ser Leu 
    610                 615                 620                 


Lys Ser Ala Leu Gly Asp Lys Ala Tyr Glu Trp Asn Asp Asn Glu Met 
625                 630                 635                 640 


Tyr Leu Phe Arg Ser Ser Val Ala Tyr Ala Met Arg Gln Tyr Phe Leu 
                645                 650                 655     


Lys Val Lys Asn Gln Met Ile Leu Phe Gly Glu Glu Asp Val Arg Val 
            660                 665                 670         


Ala Asn Leu Lys Pro Arg Ile Ser Phe Asn Phe Phe Val Thr Ala Pro 
        675                 680                 685             


Lys Asn Val Ser Asp Ile Ile Pro Arg Thr Glu Val Glu Lys Ala Ile 
    690                 695                 700                 


Arg Met Ser Arg Ser Arg Ile Asn Asp Ala Phe Arg Leu Asn Asp Asn 
705                 710                 715                 720 


Ser Leu Glu Phe Leu Gly Ile Gln Pro Thr Leu Gly Pro Pro Asn Gln 
                725                 730                 735     


Pro Pro Val Ser Ile Trp Leu Ile Val Phe Gly Val Val Met Gly Val 
            740                 745                 750         


Ile Val Val Gly Ile Val Ile Leu Ile Phe Thr Gly Ile Arg Asp Arg 
        755                 760                 765             


Lys Lys Lys Asn Lys Ala Arg Ser Gly Glu Asn Pro Tyr Ala Ser Ile 
    770                 775                 780                 


Asp Ile Ser Lys Gly Glu Asn Asn Pro Gly Phe Gln Asn Thr Asp Asp 
785                 790                 795                 800 


Val Gln Thr Ser Phe 
                805 


<210>  205
<211>  805
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H505 mutant ACE2


<220>
<221>  MUTAGEN
<222>  (505)..(505)
<223>  The sequence here can be Ala, Arg, Asn, Asp, Cys, Gln, Glu, Gly, 
       Ile, Lys, Leu, Met, Phe, Pro, Ser, Thr, Trp, Tyr, or Val.

<400>  205

Met Ser Ser Ser Ser Trp Leu Leu Leu Ser Leu Val Ala Val Thr Ala 
1               5                   10                  15      


Ala Gln Ser Thr Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Lys Phe 
            20                  25                  30          


Asn His Glu Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ser Trp 
        35                  40                  45              


Asn Tyr Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn 
    50                  55                  60                  


Ala Gly Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Leu Ala 
65                  70                  75                  80  


Gln Met Tyr Pro Leu Gln Glu Ile Gln Asn Leu Thr Val Lys Leu Gln 
                85                  90                  95      


Leu Gln Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys 
            100                 105                 110         


Ser Lys Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser 
        115                 120                 125             


Thr Gly Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu 
    130                 135                 140                 


Glu Pro Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu 
145                 150                 155                 160 


Arg Leu Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu 
                165                 170                 175     


Arg Pro Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg 
            180                 185                 190         


Ala Asn His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu 
        195                 200                 205             


Val Asn Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu 
    210                 215                 220                 


Asp Val Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu 
225                 230                 235                 240 


His Ala Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile 
                245                 250                 255     


Ser Pro Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly 
            260                 265                 270         


Arg Phe Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys 
        275                 280                 285             


Pro Asn Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala 
    290                 295                 300                 


Gln Arg Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu 
305                 310                 315                 320 


Pro Asn Met Thr Gln Gly Phe Trp Glu Asn Ser Met Leu Thr Asp Pro 
                325                 330                 335     


Gly Asn Val Gln Lys Ala Val Cys His Pro Thr Ala Trp Asp Leu Gly 
            340                 345                 350         


Lys Gly Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp 
        355                 360                 365             


Phe Leu Thr Ala His His Glu Met Gly His Ile Gln Tyr Asp Met Ala 
    370                 375                 380                 


Tyr Ala Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe 
385                 390                 395                 400 


His Glu Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys 
                405                 410                 415     


His Leu Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn 
            420                 425                 430         


Glu Thr Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly 
        435                 440                 445             


Thr Leu Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe 
    450                 455                 460                 


Lys Gly Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met 
465                 470                 475                 480 


Lys Arg Glu Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr 
                485                 490                 495     


Tyr Cys Asp Pro Ala Ser Leu Phe Xaa Val Ser Asn Asp Tyr Ser Phe 
            500                 505                 510         


Ile Arg Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala 
        515                 520                 525             


Leu Cys Gln Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile 
    530                 535                 540                 


Ser Asn Ser Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu 
545                 550                 555                 560 


Gly Lys Ser Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala 
                565                 570                 575     


Lys Asn Met Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe 
            580                 585                 590         


Thr Trp Leu Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr 
        595                 600                 605             


Asp Trp Ser Pro Tyr Ala Asp Gln Ser Ile Lys Val Arg Ile Ser Leu 
    610                 615                 620                 


Lys Ser Ala Leu Gly Asp Lys Ala Tyr Glu Trp Asn Asp Asn Glu Met 
625                 630                 635                 640 


Tyr Leu Phe Arg Ser Ser Val Ala Tyr Ala Met Arg Gln Tyr Phe Leu 
                645                 650                 655     


Lys Val Lys Asn Gln Met Ile Leu Phe Gly Glu Glu Asp Val Arg Val 
            660                 665                 670         


Ala Asn Leu Lys Pro Arg Ile Ser Phe Asn Phe Phe Val Thr Ala Pro 
        675                 680                 685             


Lys Asn Val Ser Asp Ile Ile Pro Arg Thr Glu Val Glu Lys Ala Ile 
    690                 695                 700                 


Arg Met Ser Arg Ser Arg Ile Asn Asp Ala Phe Arg Leu Asn Asp Asn 
705                 710                 715                 720 


Ser Leu Glu Phe Leu Gly Ile Gln Pro Thr Leu Gly Pro Pro Asn Gln 
                725                 730                 735     


Pro Pro Val Ser Ile Trp Leu Ile Val Phe Gly Val Val Met Gly Val 
            740                 745                 750         


Ile Val Val Gly Ile Val Ile Leu Ile Phe Thr Gly Ile Arg Asp Arg 
        755                 760                 765             


Lys Lys Lys Asn Lys Ala Arg Ser Gly Glu Asn Pro Tyr Ala Ser Ile 
    770                 775                 780                 


Asp Ile Ser Lys Gly Glu Asn Asn Pro Gly Phe Gln Asn Thr Asp Asp 
785                 790                 795                 800 


Val Gln Thr Ser Phe 
                805 


<210>  206
<211>  615
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  T27Y H34A R273K ACE2 mutant

<400>  206

Met Ser Ser Ser Ser Trp Leu Leu Leu Ser Leu Val Ala Val Thr Ala 
1               5                   10                  15      


Ala Gln Ser Thr Ile Glu Glu Gln Ala Lys Tyr Phe Leu Asp Lys Phe 
            20                  25                  30          


Asn Ala Glu Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ser Trp 
        35                  40                  45              


Asn Tyr Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn 
    50                  55                  60                  


Ala Gly Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Leu Ala 
65                  70                  75                  80  


Gln Met Tyr Pro Leu Gln Glu Ile Gln Asn Leu Thr Val Lys Leu Gln 
                85                  90                  95      


Leu Gln Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys 
            100                 105                 110         


Ser Lys Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser 
        115                 120                 125             


Thr Gly Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu 
    130                 135                 140                 


Glu Pro Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu 
145                 150                 155                 160 


Arg Leu Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu 
                165                 170                 175     


Arg Pro Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg 
            180                 185                 190         


Ala Asn His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu 
        195                 200                 205             


Val Asn Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu 
    210                 215                 220                 


Asp Val Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu 
225                 230                 235                 240 


His Ala Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile 
                245                 250                 255     


Ser Pro Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly 
            260                 265                 270         


Lys Phe Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys 
        275                 280                 285             


Pro Asn Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala 
    290                 295                 300                 


Gln Arg Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu 
305                 310                 315                 320 


Pro Asn Met Thr Gln Gly Phe Trp Glu Asn Ser Met Leu Thr Asp Pro 
                325                 330                 335     


Gly Asn Val Gln Lys Ala Val Cys His Pro Thr Ala Trp Asp Leu Gly 
            340                 345                 350         


Lys Gly Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp 
        355                 360                 365             


Phe Leu Thr Ala His His Glu Met Gly His Ile Gln Tyr Asp Met Ala 
    370                 375                 380                 


Tyr Ala Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe 
385                 390                 395                 400 


His Glu Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys 
                405                 410                 415     


His Leu Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn 
            420                 425                 430         


Glu Thr Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly 
        435                 440                 445             


Thr Leu Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe 
    450                 455                 460                 


Lys Gly Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met 
465                 470                 475                 480 


Lys Arg Glu Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr 
                485                 490                 495     


Tyr Cys Asp Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe 
            500                 505                 510         


Ile Arg Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala 
        515                 520                 525             


Leu Cys Gln Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile 
    530                 535                 540                 


Ser Asn Ser Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu 
545                 550                 555                 560 


Gly Lys Ser Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala 
                565                 570                 575     


Lys Asn Met Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe 
            580                 585                 590         


Thr Trp Leu Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr 
        595                 600                 605             


Asp Trp Ser Pro Tyr Ala Asp 
    610                 615 


<210>  207
<211>  615
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  T27Y H34A R273L ACE2 mutant

<400>  207

Met Ser Ser Ser Ser Trp Leu Leu Leu Ser Leu Val Ala Val Thr Ala 
1               5                   10                  15      


Ala Gln Ser Thr Ile Glu Glu Gln Ala Lys Tyr Phe Leu Asp Lys Phe 
            20                  25                  30          


Asn Ala Glu Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ser Trp 
        35                  40                  45              


Asn Tyr Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn 
    50                  55                  60                  


Ala Gly Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Leu Ala 
65                  70                  75                  80  


Gln Met Tyr Pro Leu Gln Glu Ile Gln Asn Leu Thr Val Lys Leu Gln 
                85                  90                  95      


Leu Gln Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys 
            100                 105                 110         


Ser Lys Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser 
        115                 120                 125             


Thr Gly Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu 
    130                 135                 140                 


Glu Pro Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu 
145                 150                 155                 160 


Arg Leu Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu 
                165                 170                 175     


Arg Pro Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg 
            180                 185                 190         


Ala Asn His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu 
        195                 200                 205             


Val Asn Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu 
    210                 215                 220                 


Asp Val Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu 
225                 230                 235                 240 


His Ala Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile 
                245                 250                 255     


Ser Pro Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly 
            260                 265                 270         


Leu Phe Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys 
        275                 280                 285             


Pro Asn Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala 
    290                 295                 300                 


Gln Arg Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu 
305                 310                 315                 320 


Pro Asn Met Thr Gln Gly Phe Trp Glu Asn Ser Met Leu Thr Asp Pro 
                325                 330                 335     


Gly Asn Val Gln Lys Ala Val Cys His Pro Thr Ala Trp Asp Leu Gly 
            340                 345                 350         


Lys Gly Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp 
        355                 360                 365             


Phe Leu Thr Ala His His Glu Met Gly His Ile Gln Tyr Asp Met Ala 
    370                 375                 380                 


Tyr Ala Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe 
385                 390                 395                 400 


His Glu Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys 
                405                 410                 415     


His Leu Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn 
            420                 425                 430         


Glu Thr Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly 
        435                 440                 445             


Thr Leu Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe 
    450                 455                 460                 


Lys Gly Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met 
465                 470                 475                 480 


Lys Arg Glu Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr 
                485                 490                 495     


Tyr Cys Asp Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe 
            500                 505                 510         


Ile Arg Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala 
        515                 520                 525             


Leu Cys Gln Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile 
    530                 535                 540                 


Ser Asn Ser Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu 
545                 550                 555                 560 


Gly Lys Ser Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala 
                565                 570                 575     


Lys Asn Met Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe 
            580                 585                 590         


Thr Trp Leu Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr 
        595                 600                 605             


Asp Trp Ser Pro Tyr Ala Asp 
    610                 615 


<210>  208
<211>  615
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  T27Y H34A H505L ACE2 mutant

<400>  208

Met Ser Ser Ser Ser Trp Leu Leu Leu Ser Leu Val Ala Val Thr Ala 
1               5                   10                  15      


Ala Gln Ser Thr Ile Glu Glu Gln Ala Lys Tyr Phe Leu Asp Lys Phe 
            20                  25                  30          


Asn Ala Glu Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ser Trp 
        35                  40                  45              


Asn Tyr Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn 
    50                  55                  60                  


Ala Gly Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Leu Ala 
65                  70                  75                  80  


Gln Met Tyr Pro Leu Gln Glu Ile Gln Asn Leu Thr Val Lys Leu Gln 
                85                  90                  95      


Leu Gln Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys 
            100                 105                 110         


Ser Lys Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser 
        115                 120                 125             


Thr Gly Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu 
    130                 135                 140                 


Glu Pro Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu 
145                 150                 155                 160 


Arg Leu Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu 
                165                 170                 175     


Arg Pro Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg 
            180                 185                 190         


Ala Asn His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu 
        195                 200                 205             


Val Asn Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu 
    210                 215                 220                 


Asp Val Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu 
225                 230                 235                 240 


His Ala Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile 
                245                 250                 255     


Ser Pro Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly 
            260                 265                 270         


Arg Phe Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys 
        275                 280                 285             


Pro Asn Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala 
    290                 295                 300                 


Gln Arg Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu 
305                 310                 315                 320 


Pro Asn Met Thr Gln Gly Phe Trp Glu Asn Ser Met Leu Thr Asp Pro 
                325                 330                 335     


Gly Asn Val Gln Lys Ala Val Cys His Pro Thr Ala Trp Asp Leu Gly 
            340                 345                 350         


Lys Gly Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp 
        355                 360                 365             


Phe Leu Thr Ala His His Glu Met Gly His Ile Gln Tyr Asp Met Ala 
    370                 375                 380                 


Tyr Ala Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe 
385                 390                 395                 400 


His Glu Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys 
                405                 410                 415     


His Leu Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn 
            420                 425                 430         


Glu Thr Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly 
        435                 440                 445             


Thr Leu Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe 
    450                 455                 460                 


Lys Gly Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met 
465                 470                 475                 480 


Lys Arg Glu Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr 
                485                 490                 495     


Tyr Cys Asp Pro Ala Ser Leu Phe Leu Val Ser Asn Asp Tyr Ser Phe 
            500                 505                 510         


Ile Arg Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala 
        515                 520                 525             


Leu Cys Gln Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile 
    530                 535                 540                 


Ser Asn Ser Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu 
545                 550                 555                 560 


Gly Lys Ser Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala 
                565                 570                 575     


Lys Asn Met Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe 
            580                 585                 590         


Thr Trp Leu Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr 
        595                 600                 605             


Asp Trp Ser Pro Tyr Ala Asp 
    610                 615 


<210>  209
<211>  615
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  T27Y H34A H374N ACE2 mutant

<400>  209

Met Ser Ser Ser Ser Trp Leu Leu Leu Ser Leu Val Ala Val Thr Ala 
1               5                   10                  15      


Ala Gln Ser Thr Ile Glu Glu Gln Ala Lys Tyr Phe Leu Asp Lys Phe 
            20                  25                  30          


Asn Ala Glu Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ser Trp 
        35                  40                  45              


Asn Tyr Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn 
    50                  55                  60                  


Ala Gly Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Leu Ala 
65                  70                  75                  80  


Gln Met Tyr Pro Leu Gln Glu Ile Gln Asn Leu Thr Val Lys Leu Gln 
                85                  90                  95      


Leu Gln Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys 
            100                 105                 110         


Ser Lys Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser 
        115                 120                 125             


Thr Gly Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu 
    130                 135                 140                 


Glu Pro Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu 
145                 150                 155                 160 


Arg Leu Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu 
                165                 170                 175     


Arg Pro Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg 
            180                 185                 190         


Ala Asn His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu 
        195                 200                 205             


Val Asn Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu 
    210                 215                 220                 


Asp Val Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu 
225                 230                 235                 240 


His Ala Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile 
                245                 250                 255     


Ser Pro Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly 
            260                 265                 270         


Arg Phe Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys 
        275                 280                 285             


Pro Asn Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala 
    290                 295                 300                 


Gln Arg Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu 
305                 310                 315                 320 


Pro Asn Met Thr Gln Gly Phe Trp Glu Asn Ser Met Leu Thr Asp Pro 
                325                 330                 335     


Gly Asn Val Gln Lys Ala Val Cys His Pro Thr Ala Trp Asp Leu Gly 
            340                 345                 350         


Lys Gly Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp 
        355                 360                 365             


Phe Leu Thr Ala His Asn Glu Met Gly His Ile Gln Tyr Asp Met Ala 
    370                 375                 380                 


Tyr Ala Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe 
385                 390                 395                 400 


His Glu Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys 
                405                 410                 415     


His Leu Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn 
            420                 425                 430         


Glu Thr Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly 
        435                 440                 445             


Thr Leu Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe 
    450                 455                 460                 


Lys Gly Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met 
465                 470                 475                 480 


Lys Arg Glu Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr 
                485                 490                 495     


Tyr Cys Asp Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe 
            500                 505                 510         


Ile Arg Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala 
        515                 520                 525             


Leu Cys Gln Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile 
    530                 535                 540                 


Ser Asn Ser Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu 
545                 550                 555                 560 


Gly Lys Ser Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala 
                565                 570                 575     


Lys Asn Met Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe 
            580                 585                 590         


Thr Trp Leu Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr 
        595                 600                 605             


Asp Trp Ser Pro Tyr Ala Asp 
    610                 615 


<210>  210
<211>  615
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  T27Y H34A H378N ACE2 mutant

<400>  210

Met Ser Ser Ser Ser Trp Leu Leu Leu Ser Leu Val Ala Val Thr Ala 
1               5                   10                  15      


Ala Gln Ser Thr Ile Glu Glu Gln Ala Lys Tyr Phe Leu Asp Lys Phe 
            20                  25                  30          


Asn Ala Glu Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ser Trp 
        35                  40                  45              


Asn Tyr Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn 
    50                  55                  60                  


Ala Gly Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Leu Ala 
65                  70                  75                  80  


Gln Met Tyr Pro Leu Gln Glu Ile Gln Asn Leu Thr Val Lys Leu Gln 
                85                  90                  95      


Leu Gln Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys 
            100                 105                 110         


Ser Lys Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser 
        115                 120                 125             


Thr Gly Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu 
    130                 135                 140                 


Glu Pro Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu 
145                 150                 155                 160 


Arg Leu Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu 
                165                 170                 175     


Arg Pro Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg 
            180                 185                 190         


Ala Asn His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu 
        195                 200                 205             


Val Asn Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu 
    210                 215                 220                 


Asp Val Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu 
225                 230                 235                 240 


His Ala Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile 
                245                 250                 255     


Ser Pro Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly 
            260                 265                 270         


Arg Phe Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys 
        275                 280                 285             


Pro Asn Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala 
    290                 295                 300                 


Gln Arg Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu 
305                 310                 315                 320 


Pro Asn Met Thr Gln Gly Phe Trp Glu Asn Ser Met Leu Thr Asp Pro 
                325                 330                 335     


Gly Asn Val Gln Lys Ala Val Cys His Pro Thr Ala Trp Asp Leu Gly 
            340                 345                 350         


Lys Gly Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp 
        355                 360                 365             


Phe Leu Thr Ala His His Glu Met Gly Asn Ile Gln Tyr Asp Met Ala 
    370                 375                 380                 


Tyr Ala Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe 
385                 390                 395                 400 


His Glu Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys 
                405                 410                 415     


His Leu Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn 
            420                 425                 430         


Glu Thr Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly 
        435                 440                 445             


Thr Leu Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe 
    450                 455                 460                 


Lys Gly Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met 
465                 470                 475                 480 


Lys Arg Glu Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr 
                485                 490                 495     


Tyr Cys Asp Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe 
            500                 505                 510         


Ile Arg Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala 
        515                 520                 525             


Leu Cys Gln Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile 
    530                 535                 540                 


Ser Asn Ser Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu 
545                 550                 555                 560 


Gly Lys Ser Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala 
                565                 570                 575     


Lys Asn Met Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe 
            580                 585                 590         


Thr Trp Leu Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr 
        595                 600                 605             


Asp Trp Ser Pro Tyr Ala Asp 
    610                 615 


<210>  211
<211>  614
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  T27Y H34A H345A ACE2 mutant

<400>  211

Met Ser Ser Ser Ser Trp Leu Leu Leu Ser Leu Val Ala Val Thr Ala 
1               5                   10                  15      


Ala Gln Ser Thr Ile Glu Glu Gln Ala Lys Tyr Phe Leu Asp Lys Phe 
            20                  25                  30          


Asn Ala Glu Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ser Trp 
        35                  40                  45              


Asn Tyr Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn 
    50                  55                  60                  


Ala Gly Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Leu Ala 
65                  70                  75                  80  


Gln Met Tyr Pro Leu Gln Glu Ile Gln Asn Leu Thr Val Lys Leu Gln 
                85                  90                  95      


Leu Gln Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys 
            100                 105                 110         


Ser Lys Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser 
        115                 120                 125             


Thr Gly Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu 
    130                 135                 140                 


Glu Pro Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu 
145                 150                 155                 160 


Arg Leu Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu 
                165                 170                 175     


Arg Pro Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg 
            180                 185                 190         


Ala Asn His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu 
        195                 200                 205             


Val Asn Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu 
    210                 215                 220                 


Asp Val Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu 
225                 230                 235                 240 


His Ala Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile 
                245                 250                 255     


Ser Pro Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly 
            260                 265                 270         


Arg Phe Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys 
        275                 280                 285             


Pro Asn Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala 
    290                 295                 300                 


Gln Arg Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu 
305                 310                 315                 320 


Pro Asn Met Thr Gln Gly Phe Trp Glu Asn Ser Met Leu Thr Asp Pro 
                325                 330                 335     


Gly Asn Val Gln Lys Ala Val Cys Ala Pro Thr Ala Trp Asp Leu Gly 
            340                 345                 350         


Lys Gly Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp 
        355                 360                 365             


Phe Leu Thr Ala His His Glu Met Gly His Ile Gln Tyr Asp Met Ala 
    370                 375                 380                 


Tyr Ala Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe 
385                 390                 395                 400 


His Glu Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys 
                405                 410                 415     


His Leu Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn 
            420                 425                 430         


Glu Thr Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly 
        435                 440                 445             


Thr Leu Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe 
    450                 455                 460                 


Lys Gly Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met 
465                 470                 475                 480 


Lys Arg Glu Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr 
                485                 490                 495     


Tyr Cys Asp Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe 
            500                 505                 510         


Ile Arg Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala 
        515                 520                 525             


Leu Cys Gln Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile 
    530                 535                 540                 


Ser Asn Ser Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu 
545                 550                 555                 560 


Gly Lys Ser Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala 
                565                 570                 575     


Lys Asn Met Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe 
            580                 585                 590         


Thr Trp Leu Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr 
        595                 600                 605             


Asp Trp Ser Pro Tyr Ala 
    610                 


<210>  212
<211>  615
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  T27Y H34A R273Q ACE2 mutant

<400>  212

Met Ser Ser Ser Ser Trp Leu Leu Leu Ser Leu Val Ala Val Thr Ala 
1               5                   10                  15      


Ala Gln Ser Thr Ile Glu Glu Gln Ala Lys Tyr Phe Leu Asp Lys Phe 
            20                  25                  30          


Asn Ala Glu Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ser Trp 
        35                  40                  45              


Asn Tyr Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn 
    50                  55                  60                  


Ala Gly Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Leu Ala 
65                  70                  75                  80  


Gln Met Tyr Pro Leu Gln Glu Ile Gln Asn Leu Thr Val Lys Leu Gln 
                85                  90                  95      


Leu Gln Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys 
            100                 105                 110         


Ser Lys Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser 
        115                 120                 125             


Thr Gly Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu 
    130                 135                 140                 


Glu Pro Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu 
145                 150                 155                 160 


Arg Leu Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu 
                165                 170                 175     


Arg Pro Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg 
            180                 185                 190         


Ala Asn His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu 
        195                 200                 205             


Val Asn Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu 
    210                 215                 220                 


Asp Val Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu 
225                 230                 235                 240 


His Ala Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile 
                245                 250                 255     


Ser Pro Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly 
            260                 265                 270         


Gln Phe Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys 
        275                 280                 285             


Pro Asn Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala 
    290                 295                 300                 


Gln Arg Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu 
305                 310                 315                 320 


Pro Asn Met Thr Gln Gly Phe Trp Glu Asn Ser Met Leu Thr Asp Pro 
                325                 330                 335     


Gly Asn Val Gln Lys Ala Val Cys His Pro Thr Ala Trp Asp Leu Gly 
            340                 345                 350         


Lys Gly Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp 
        355                 360                 365             


Phe Leu Thr Ala His His Glu Met Gly His Ile Gln Tyr Asp Met Ala 
    370                 375                 380                 


Tyr Ala Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe 
385                 390                 395                 400 


His Glu Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys 
                405                 410                 415     


His Leu Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn 
            420                 425                 430         


Glu Thr Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly 
        435                 440                 445             


Thr Leu Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe 
    450                 455                 460                 


Lys Gly Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met 
465                 470                 475                 480 


Lys Arg Glu Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr 
                485                 490                 495     


Tyr Cys Asp Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe 
            500                 505                 510         


Ile Arg Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala 
        515                 520                 525             


Leu Cys Gln Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile 
    530                 535                 540                 


Ser Asn Ser Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu 
545                 550                 555                 560 


Gly Lys Ser Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala 
                565                 570                 575     


Lys Asn Met Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe 
            580                 585                 590         


Thr Trp Leu Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr 
        595                 600                 605             


Asp Trp Ser Pro Tyr Ala Asp 
    610                 615 


<210>  213
<211>  1845
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CDS for T27Y H34A R273K ACE2 mutant

<400>  213
atgagcagca gtagttggct tctcttgagt ttggtggcag tgacagcagc ccagagtact       60

atcgaggagc aggctaaata ctttctggat aagtttaacg ccgaggccga agacttgttc      120

tatcaatctt ctctcgcttc atggaattac aatactaaca tcactgagga gaacgtccag      180

aatatgaaca atgctggcga caaatggagc gccttcttga aggagcagtc tacccttgca      240

caaatgtatc cactgcagga gatacagaac cttacagtaa agttgcagct ccaggctctc      300

cagcagaacg gatctagcgt gctttcagag gataaaagca aaaggctgaa caccatactt      360

aataccatgt ccacaattta ctctactggt aaagtatgta accccgacaa ccctcaagaa      420

tgcctccttc ttgagccagg cctcaatgag atcatggcta atagtctgga ctataatgaa      480

agactgtggg catgggagtc ctggagatct gaagtaggga agcaactgag gcccctttat      540

gaagagtacg tcgtacttaa gaatgaaatg gcccgcgcta accactacga ggattacggc      600

gattactggc gtggggacta tgaagtaaat ggtgtagatg gatacgacta tagtcgtggg      660

caattgattg aggatgtgga gcacactttt gaggagataa aaccactcta tgagcatctt      720

cacgcatatg tgagagctaa actgatgaac gcctacccaa gttacatcag tccaatcgga      780

tgtctcccag ctcacctcct tggcgacatg tggggaaagt tctggaccaa tctgtattcc      840

ctcacagtcc ctttcgggca aaagcctaat atagacgtga cagacgcaat ggttgatcag      900

gcttgggatg ctcaaaggat ttttaaggaa gctgagaagt tttttgtgtc agtcggtttg      960

ccaaatatga cacaaggctt ctgggaaaat agcatgttga ctgatcccgg taatgttcaa     1020

aaggctgtgt gtcaccctac cgcttgggac cttgggaaag gtgactttcg aatcttgatg     1080

tgtaccaagg tgacaatgga tgactttctt acagcccatc atgaaatggg tcacatccag     1140

tatgatatgg cttatgcagc tcaacctttc ctcttgagaa atggtgcaaa tgaaggtttt     1200

catgaagctg taggggaaat aatgtccctg agtgctgcaa ccccaaagca tctcaagagt     1260

atcggattgt tgagcccaga ttttcaagaa gataacgaga ccgaaatcaa cttccttctg     1320

aaacaagccc tcacaatagt tggtactctt ccattcacat acatgctgga gaaatggcgt     1380

tggatggttt ttaaggggga gatacctaaa gatcagtgga tgaaaaagtg gtgggagatg     1440

aagcgtgaga tcgtaggggt cgtggagcca gtgcctcatg atgagactta ctgtgaccca     1500

gcatcactct tccacgttag caatgactat tcatttatac gttattacac tcgcactctt     1560

taccagtttc aatttcagga ggctctgtgt caggctgcca agcatgaggg accccttcac     1620

aagtgtgata ttagtaacag tactgaggca ggccaaaaac tgttcaatat gttgaggctt     1680

ggcaaaagcg agccatggac tctcgccttg gaaaatgttg tcggggctaa aaacatgaat     1740

gtacgccctc tgcttaacta ttttgagccc ctttttacat ggctcaagga ccagaataag     1800

aactcctttg tcggctggtc aacagactgg tctccctatg cagac                     1845


<210>  214
<211>  1845
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CDS for T27Y H34A R273L ACE2 mutant

<400>  214
atgagcagca gtagttggct tctcttgagt ttggtggcag tgacagcagc ccagagtact       60

atcgaggagc aggctaaata ctttctggat aagtttaacg ccgaggccga agacttgttc      120

tatcaatctt ctctcgcttc atggaattac aatactaaca tcactgagga gaacgtccag      180

aatatgaaca atgctggcga caaatggagc gccttcttga aggagcagtc tacccttgca      240

caaatgtatc cactgcagga gatacagaac cttacagtaa agttgcagct ccaggctctc      300

cagcagaacg gatctagcgt gctttcagag gataaaagca aaaggctgaa caccatactt      360

aataccatgt ccacaattta ctctactggt aaagtatgta accccgacaa ccctcaagaa      420

tgcctccttc ttgagccagg cctcaatgag atcatggcta atagtctgga ctataatgaa      480

agactgtggg catgggagtc ctggagatct gaagtaggga agcaactgag gcccctttat      540

gaagagtacg tcgtacttaa gaatgaaatg gcccgcgcta accactacga ggattacggc      600

gattactggc gtggggacta tgaagtaaat ggtgtagatg gatacgacta tagtcgtggg      660

caattgattg aggatgtgga gcacactttt gaggagataa aaccactcta tgagcatctt      720

cacgcatatg tgagagctaa actgatgaac gcctacccaa gttacatcag tccaatcgga      780

tgtctcccag ctcacctcct tggcgacatg tggggactgt tctggaccaa tctgtattcc      840

ctcacagtcc ctttcgggca aaagcctaat atagacgtga cagacgcaat ggttgatcag      900

gcttgggatg ctcaaaggat ttttaaggaa gctgagaagt tttttgtgtc agtcggtttg      960

ccaaatatga cacaaggctt ctgggaaaat agcatgttga ctgatcccgg taatgttcaa     1020

aaggctgtgt gtcaccctac cgcttgggac cttgggaaag gtgactttcg aatcttgatg     1080

tgtaccaagg tgacaatgga tgactttctt acagcccatc atgaaatggg tcacatccag     1140

tatgatatgg cttatgcagc tcaacctttc ctcttgagaa atggtgcaaa tgaaggtttt     1200

catgaagctg taggggaaat aatgtccctg agtgctgcaa ccccaaagca tctcaagagt     1260

atcggattgt tgagcccaga ttttcaagaa gataacgaga ccgaaatcaa cttccttctg     1320

aaacaagccc tcacaatagt tggtactctt ccattcacat acatgctgga gaaatggcgt     1380

tggatggttt ttaaggggga gatacctaaa gatcagtgga tgaaaaagtg gtgggagatg     1440

aagcgtgaga tcgtaggggt cgtggagcca gtgcctcatg atgagactta ctgtgaccca     1500

gcatcactct tccacgttag caatgactat tcatttatac gttattacac tcgcactctt     1560

taccagtttc aatttcagga ggctctgtgt caggctgcca agcatgaggg accccttcac     1620

aagtgtgata ttagtaacag tactgaggca ggccaaaaac tgttcaatat gttgaggctt     1680

ggcaaaagcg agccatggac tctcgccttg gaaaatgttg tcggggctaa aaacatgaat     1740

gtacgccctc tgcttaacta ttttgagccc ctttttacat ggctcaagga ccagaataag     1800

aactcctttg tcggctggtc aacagactgg tctccctatg cagac                     1845


<210>  215
<211>  1845
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CDS for T27Y H34A H505L ACE2 mutant

<400>  215
atgagcagca gtagttggct tctcttgagt ttggtggcag tgacagcagc ccagagtact       60

atcgaggagc aggctaaata ctttctggat aagtttaacg ccgaggccga agacttgttc      120

tatcaatctt ctctcgcttc atggaattac aatactaaca tcactgagga gaacgtccag      180

aatatgaaca atgctggcga caaatggagc gccttcttga aggagcagtc tacccttgca      240

caaatgtatc cactgcagga gatacagaac cttacagtaa agttgcagct ccaggctctc      300

cagcagaacg gatctagcgt gctttcagag gataaaagca aaaggctgaa caccatactt      360

aataccatgt ccacaattta ctctactggt aaagtatgta accccgacaa ccctcaagaa      420

tgcctccttc ttgagccagg cctcaatgag atcatggcta atagtctgga ctataatgaa      480

agactgtggg catgggagtc ctggagatct gaagtaggga agcaactgag gcccctttat      540

gaagagtacg tcgtacttaa gaatgaaatg gcccgcgcta accactacga ggattacggc      600

gattactggc gtggggacta tgaagtaaat ggtgtagatg gatacgacta tagtcgtggg      660

caattgattg aggatgtgga gcacactttt gaggagataa aaccactcta tgagcatctt      720

cacgcatatg tgagagctaa actgatgaac gcctacccaa gttacatcag tccaatcgga      780

tgtctcccag ctcacctcct tggcgacatg tggggacgtt tctggaccaa tctgtattcc      840

ctcacagtcc ctttcgggca aaagcctaat atagacgtga cagacgcaat ggttgatcag      900

gcttgggatg ctcaaaggat ttttaaggaa gctgagaagt tttttgtgtc agtcggtttg      960

ccaaatatga cacaaggctt ctgggaaaat agcatgttga ctgatcccgg taatgttcaa     1020

aaggctgtgt gtcaccctac cgcttgggac cttgggaaag gtgactttcg aatcttgatg     1080

tgtaccaagg tgacaatgga tgactttctt acagcccatc atgaaatggg tcacatccag     1140

tatgatatgg cttatgcagc tcaacctttc ctcttgagaa atggtgcaaa tgaaggtttt     1200

catgaagctg taggggaaat aatgtccctg agtgctgcaa ccccaaagca tctcaagagt     1260

atcggattgt tgagcccaga ttttcaagaa gataacgaga ccgaaatcaa cttccttctg     1320

aaacaagccc tcacaatagt tggtactctt ccattcacat acatgctgga gaaatggcgt     1380

tggatggttt ttaaggggga gatacctaaa gatcagtgga tgaaaaagtg gtgggagatg     1440

aagcgtgaga tcgtaggggt cgtggagcca gtgcctcatg atgagactta ctgtgaccca     1500

gcatcactct tcctggttag caatgactat tcatttatac gttattacac tcgcactctt     1560

taccagtttc aatttcagga ggctctgtgt caggctgcca agcatgaggg accccttcac     1620

aagtgtgata ttagtaacag tactgaggca ggccaaaaac tgttcaatat gttgaggctt     1680

ggcaaaagcg agccatggac tctcgccttg gaaaatgttg tcggggctaa aaacatgaat     1740

gtacgccctc tgcttaacta ttttgagccc ctttttacat ggctcaagga ccagaataag     1800

aactcctttg tcggctggtc aacagactgg tctccctatg cagac                     1845


<210>  216
<211>  1845
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CDS for T27Y H34A H374N ACE2 mutant

<400>  216
atgagcagca gtagttggct tctcttgagt ttggtggcag tgacagcagc ccagagtact       60

atcgaggagc aggctaaata ctttctggat aagtttaacg ccgaggccga agacttgttc      120

tatcaatctt ctctcgcttc atggaattac aatactaaca tcactgagga gaacgtccag      180

aatatgaaca atgctggcga caaatggagc gccttcttga aggagcagtc tacccttgca      240

caaatgtatc cactgcagga gatacagaac cttacagtaa agttgcagct ccaggctctc      300

cagcagaacg gatctagcgt gctttcagag gataaaagca aaaggctgaa caccatactt      360

aataccatgt ccacaattta ctctactggt aaagtatgta accccgacaa ccctcaagaa      420

tgcctccttc ttgagccagg cctcaatgag atcatggcta atagtctgga ctataatgaa      480

agactgtggg catgggagtc ctggagatct gaagtaggga agcaactgag gcccctttat      540

gaagagtacg tcgtacttaa gaatgaaatg gcccgcgcta accactacga ggattacggc      600

gattactggc gtggggacta tgaagtaaat ggtgtagatg gatacgacta tagtcgtggg      660

caattgattg aggatgtgga gcacactttt gaggagataa aaccactcta tgagcatctt      720

cacgcatatg tgagagctaa actgatgaac gcctacccaa gttacatcag tccaatcgga      780

tgtctcccag ctcacctcct tggcgacatg tggggacgtt tctggaccaa tctgtattcc      840

ctcacagtcc ctttcgggca aaagcctaat atagacgtga cagacgcaat ggttgatcag      900

gcttgggatg ctcaaaggat ttttaaggaa gctgagaagt tttttgtgtc agtcggtttg      960

ccaaatatga cacaaggctt ctgggaaaat agcatgttga ctgatcccgg taatgttcaa     1020

aaggctgtgt gtcaccctac cgcttgggac cttgggaaag gtgactttcg aatcttgatg     1080

tgtaccaagg tgacaatgga tgactttctt acagcccata atgaaatggg tcacatccag     1140

tatgatatgg cttatgcagc tcaacctttc ctcttgagaa atggtgcaaa tgaaggtttt     1200

catgaagctg taggggaaat aatgtccctg agtgctgcaa ccccaaagca tctcaagagt     1260

atcggattgt tgagcccaga ttttcaagaa gataacgaga ccgaaatcaa cttccttctg     1320

aaacaagccc tcacaatagt tggtactctt ccattcacat acatgctgga gaaatggcgt     1380

tggatggttt ttaaggggga gatacctaaa gatcagtgga tgaaaaagtg gtgggagatg     1440

aagcgtgaga tcgtaggggt cgtggagcca gtgcctcatg atgagactta ctgtgaccca     1500

gcatcactct tccacgttag caatgactat tcatttatac gttattacac tcgcactctt     1560

taccagtttc aatttcagga ggctctgtgt caggctgcca agcatgaggg accccttcac     1620

aagtgtgata ttagtaacag tactgaggca ggccaaaaac tgttcaatat gttgaggctt     1680

ggcaaaagcg agccatggac tctcgccttg gaaaatgttg tcggggctaa aaacatgaat     1740

gtacgccctc tgcttaacta ttttgagccc ctttttacat ggctcaagga ccagaataag     1800

aactcctttg tcggctggtc aacagactgg tctccctatg cagac                     1845


<210>  217
<211>  1845
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CDS for T27Y H34A H378N ACE2 mutant

<400>  217
atgagcagca gtagttggct tctcttgagt ttggtggcag tgacagcagc ccagagtact       60

atcgaggagc aggctaaata ctttctggat aagtttaacg ccgaggccga agacttgttc      120

tatcaatctt ctctcgcttc atggaattac aatactaaca tcactgagga gaacgtccag      180

aatatgaaca atgctggcga caaatggagc gccttcttga aggagcagtc tacccttgca      240

caaatgtatc cactgcagga gatacagaac cttacagtaa agttgcagct ccaggctctc      300

cagcagaacg gatctagcgt gctttcagag gataaaagca aaaggctgaa caccatactt      360

aataccatgt ccacaattta ctctactggt aaagtatgta accccgacaa ccctcaagaa      420

tgcctccttc ttgagccagg cctcaatgag atcatggcta atagtctgga ctataatgaa      480

agactgtggg catgggagtc ctggagatct gaagtaggga agcaactgag gcccctttat      540

gaagagtacg tcgtacttaa gaatgaaatg gcccgcgcta accactacga ggattacggc      600

gattactggc gtggggacta tgaagtaaat ggtgtagatg gatacgacta tagtcgtggg      660

caattgattg aggatgtgga gcacactttt gaggagataa aaccactcta tgagcatctt      720

cacgcatatg tgagagctaa actgatgaac gcctacccaa gttacatcag tccaatcgga      780

tgtctcccag ctcacctcct tggcgacatg tggggacgtt tctggaccaa tctgtattcc      840

ctcacagtcc ctttcgggca aaagcctaat atagacgtga cagacgcaat ggttgatcag      900

gcttgggatg ctcaaaggat ttttaaggaa gctgagaagt tttttgtgtc agtcggtttg      960

ccaaatatga cacaaggctt ctgggaaaat agcatgttga ctgatcccgg taatgttcaa     1020

aaggctgtgt gtcaccctac cgcttgggac cttgggaaag gtgactttcg aatcttgatg     1080

tgtaccaagg tgacaatgga tgactttctt acagcccatc atgaaatggg taatatccag     1140

tatgatatgg cttatgcagc tcaacctttc ctcttgagaa atggtgcaaa tgaaggtttt     1200

catgaagctg taggggaaat aatgtccctg agtgctgcaa ccccaaagca tctcaagagt     1260

atcggattgt tgagcccaga ttttcaagaa gataacgaga ccgaaatcaa cttccttctg     1320

aaacaagccc tcacaatagt tggtactctt ccattcacat acatgctgga gaaatggcgt     1380

tggatggttt ttaaggggga gatacctaaa gatcagtgga tgaaaaagtg gtgggagatg     1440

aagcgtgaga tcgtaggggt cgtggagcca gtgcctcatg atgagactta ctgtgaccca     1500

gcatcactct tccacgttag caatgactat tcatttatac gttattacac tcgcactctt     1560

taccagtttc aatttcagga ggctctgtgt caggctgcca agcatgaggg accccttcac     1620

aagtgtgata ttagtaacag tactgaggca ggccaaaaac tgttcaatat gttgaggctt     1680

ggcaaaagcg agccatggac tctcgccttg gaaaatgttg tcggggctaa aaacatgaat     1740

gtacgccctc tgcttaacta ttttgagccc ctttttacat ggctcaagga ccagaataag     1800

aactcctttg tcggctggtc aacagactgg tctccctatg cagac                     1845


<210>  218
<211>  1845
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CDS for T27Y H34A H345A ACE2 mutant

<400>  218
atgagcagca gtagttggct tctcttgagt ttggtggcag tgacagcagc ccagagtact       60

atcgaggagc aggctaaata ctttctggat aagtttaacg ccgaggccga agacttgttc      120

tatcaatctt ctctcgcttc atggaattac aatactaaca tcactgagga gaacgtccag      180

aatatgaaca atgctggcga caaatggagc gccttcttga aggagcagtc tacccttgca      240

caaatgtatc cactgcagga gatacagaac cttacagtaa agttgcagct ccaggctctc      300

cagcagaacg gatctagcgt gctttcagag gataaaagca aaaggctgaa caccatactt      360

aataccatgt ccacaattta ctctactggt aaagtatgta accccgacaa ccctcaagaa      420

tgcctccttc ttgagccagg cctcaatgag atcatggcta atagtctgga ctataatgaa      480

agactgtggg catgggagtc ctggagatct gaagtaggga agcaactgag gcccctttat      540

gaagagtacg tcgtacttaa gaatgaaatg gcccgcgcta accactacga ggattacggc      600

gattactggc gtggggacta tgaagtaaat ggtgtagatg gatacgacta tagtcgtggg      660

caattgattg aggatgtgga gcacactttt gaggagataa aaccactcta tgagcatctt      720

cacgcatatg tgagagctaa actgatgaac gcctacccaa gttacatcag tccaatcgga      780

tgtctcccag ctcacctcct tggcgacatg tggggacgtt tctggaccaa tctgtattcc      840

ctcacagtcc ctttcgggca aaagcctaat atagacgtga cagacgcaat ggttgatcag      900

gcttgggatg ctcaaaggat ttttaaggaa gctgagaagt tttttgtgtc agtcggtttg      960

ccaaatatga cacaaggctt ctgggaaaat agcatgttga ctgatcccgg taatgttcaa     1020

aaggctgtgt gtgcccctac cgcttgggac cttgggaaag gtgactttcg aatcttgatg     1080

tgtaccaagg tgacaatgga tgactttctt acagcccatc atgaaatggg tcacatccag     1140

tatgatatgg cttatgcagc tcaacctttc ctcttgagaa atggtgcaaa tgaaggtttt     1200

catgaagctg taggggaaat aatgtccctg agtgctgcaa ccccaaagca tctcaagagt     1260

atcggattgt tgagcccaga ttttcaagaa gataacgaga ccgaaatcaa cttccttctg     1320

aaacaagccc tcacaatagt tggtactctt ccattcacat acatgctgga gaaatggcgt     1380

tggatggttt ttaaggggga gatacctaaa gatcagtgga tgaaaaagtg gtgggagatg     1440

aagcgtgaga tcgtaggggt cgtggagcca gtgcctcatg atgagactta ctgtgaccca     1500

gcatcactct tccacgttag caatgactat tcatttatac gttattacac tcgcactctt     1560

taccagtttc aatttcagga ggctctgtgt caggctgcca agcatgaggg accccttcac     1620

aagtgtgata ttagtaacag tactgaggca ggccaaaaac tgttcaatat gttgaggctt     1680

ggcaaaagcg agccatggac tctcgccttg gaaaatgttg tcggggctaa aaacatgaat     1740

gtacgccctc tgcttaacta ttttgagccc ctttttacat ggctcaagga ccagaataag     1800

aactcctttg tcggctggtc aacagactgg tctccctatg cagac                     1845


<210>  219
<211>  1845
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CDS for T27Y H34A R273Q ACE2 mutant

<400>  219
atgagcagca gtagttggct tctcttgagt ttggtggcag tgacagcagc ccagagtact       60

atcgaggagc aggctaaata ctttctggat aagtttaacg ccgaggccga agacttgttc      120

tatcaatctt ctctcgcttc atggaattac aatactaaca tcactgagga gaacgtccag      180

aatatgaaca atgctggcga caaatggagc gccttcttga aggagcagtc tacccttgca      240

caaatgtatc cactgcagga gatacagaac cttacagtaa agttgcagct ccaggctctc      300

cagcagaacg gatctagcgt gctttcagag gataaaagca aaaggctgaa caccatactt      360

aataccatgt ccacaattta ctctactggt aaagtatgta accccgacaa ccctcaagaa      420

tgcctccttc ttgagccagg cctcaatgag atcatggcta atagtctgga ctataatgaa      480

agactgtggg catgggagtc ctggagatct gaagtaggga agcaactgag gcccctttat      540

gaagagtacg tcgtacttaa gaatgaaatg gcccgcgcta accactacga ggattacggc      600

gattactggc gtggggacta tgaagtaaat ggtgtagatg gatacgacta tagtcgtggg      660

caattgattg aggatgtgga gcacactttt gaggagataa aaccactcta tgagcatctt      720

cacgcatatg tgagagctaa actgatgaac gcctacccaa gttacatcag tccaatcgga      780

tgtctcccag ctcacctcct tggcgacatg tggggacagt tctggaccaa tctgtattcc      840

ctcacagtcc ctttcgggca aaagcctaat atagacgtga cagacgcaat ggttgatcag      900

gcttgggatg ctcaaaggat ttttaaggaa gctgagaagt tttttgtgtc agtcggtttg      960

ccaaatatga cacaaggctt ctgggaaaat agcatgttga ctgatcccgg taatgttcaa     1020

aaggctgtgt gtcaccctac cgcttgggac cttgggaaag gtgactttcg aatcttgatg     1080

tgtaccaagg tgacaatgga tgactttctt acagcccatc atgaaatggg tcacatccag     1140

tatgatatgg cttatgcagc tcaacctttc ctcttgagaa atggtgcaaa tgaaggtttt     1200

catgaagctg taggggaaat aatgtccctg agtgctgcaa ccccaaagca tctcaagagt     1260

atcggattgt tgagcccaga ttttcaagaa gataacgaga ccgaaatcaa cttccttctg     1320

aaacaagccc tcacaatagt tggtactctt ccattcacat acatgctgga gaaatggcgt     1380

tggatggttt ttaaggggga gatacctaaa gatcagtgga tgaaaaagtg gtgggagatg     1440

aagcgtgaga tcgtaggggt cgtggagcca gtgcctcatg atgagactta ctgtgaccca     1500

gcatcactct tccacgttag caatgactat tcatttatac gttattacac tcgcactctt     1560

taccagtttc aatttcagga ggctctgtgt caggctgcca agcatgaggg accccttcac     1620

aagtgtgata ttagtaacag tactgaggca ggccaaaaac tgttcaatat gttgaggctt     1680

ggcaaaagcg agccatggac tctcgccttg gaaaatgttg tcggggctaa aaacatgaat     1740

gtacgccctc tgcttaacta ttttgagccc ctttttacat ggctcaagga ccagaataag     1800

aactcctttg tcggctggtc aacagactgg tctccctatg cagac                     1845


<210>  220
<211>  38496
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  vector for IgA against T27Y H34A R273K ACE2 mutant

<400>  220
tattattgat gatgttaatt aacatgcatg gatcctacgt ctcgaccgat gcccttgaga       60

gccttcaacc cagtcagctc cttccggtgg gcgcggggca tgactatcgt cgccgcactt      120

atgactgtct tctttatcat gcaactcgta ggacaggtgc cggcagcgct ctgggtcatt      180

ttcggcgagg accgctttcg ctggagcgcg acgatgatcg gcctgtcgct tgcggtattc      240

ggaatcttgc acgccctcgc tcaagccttc gtcactggtc ccgccaccaa acgtttcggc      300

gagaagcagg ccattatcgc cggcatggcg gccgacgcgc tgggctacgt cttgctggcg      360

ttcgcgacgc gaggctggat ggccttcccc attatgattc ttctcgcttc cggcggcatc      420

gggatgcccg cgttgcaggc catgctgtcc aggcaggtag atgacgacca tcagggacag      480

cttcaaggat cgctcgcggc tcttaccagc ctaacttcga tcattggacc gctgatcgtc      540

acggcgattt atgccgcctc ggcgagcaca tggaacgggt tggcatggat tgtaggcgcc      600

gccctatacc ttgtctgcct ccccgcgttg cgtcgcggtg catggagccg ggccacctcg      660

acctgaatgg aagccggcgg cacctcgcta acggattcac cactccaaga attggagcca      720

atcaattctt gcggagaact gtgaatgcgc aaaccaaccc ttggcagaac atatccatcg      780

cgtccgccat ctccagcagc cgcacgcggc gcatctcggg cagcgttggg tcctggccac      840

gggtgcgcat gatcgtgctc ctgtcgttga ggacccggct aggctggcgg ggttgcctta      900

ctggttagca gaatgaatca ccgatacgcg agcgaacgtg aagcgactgc tgctgcaaaa      960

cgtctgcgac ctgagcaaca acatgaatgg tcttcggttt ccgtgtttcg taaagtctgg     1020

aaacgcggaa gtcagcgccc tgcaccatta tgttccggat ctgcatcgca ggatgctgct     1080

ggctaccctg tggaacacct acatctgtat taacgaagcg ctggcattga ccctgagtga     1140

tttttctctg gtcccgccgc atccataccg ccagttgttt accctcacaa cgttccagta     1200

accgggcatg ttcatcatca gtaacccgta tcgtgagcat cctctctcgt ttcatcggta     1260

tcattacccc catgaacaga aatccccctt acacggaggc atcagtgacc aaacaggaaa     1320

aaaccgccct taacatggcc cgctttatca gaagccagac attaacgctt ctggagaaac     1380

tcaacgagct ggacgcggat gaacaggcag acatctgtga atcgcttcac gaccacgctg     1440

atgagcttta ccgcagctgc ctcgcgcgtt tcggtgatga cggtgaaaac ctctgacaca     1500

tgcagctccc ggagacggtc acagcttgtc tgtaagcgga tgccgggagc agacaagccc     1560

gtcagggcgc gtcagcgggt gttggcgggt gtcggggcgc agccatgacc cagtcacgta     1620

gcgatagcgg agtgtatact ggcttaacta tgcggcatca gagcagattg tactgagagt     1680

gcaccatatg cggtgtgaaa taccgcacag atgcgtaagg agaaaatacc gcatcaggcg     1740

ctcttccgct tcctcgctca ctgactcgct gcgctcggtc gttcggctgc ggcgagcggt     1800

atcagctcac tcaaaggcgg taatacggtt atccacagaa tcaggggata acgcaggaaa     1860

gaacatgtga gcaaaaggcc agcaaaaggc caggaaccgt aaaaaggccg cgttgctggc     1920

gtttttccat aggctccgcc cccctgacga gcatcacaaa aatcgacgct caagtcagag     1980

gtggcgaaac ccgacaggac tataaagata ccaggcgttt ccccctggaa gctccctcgt     2040

gcgctctcct gttccgaccc tgccgcttac cggatacctg tccgcctttc tcccttcggg     2100

aagcgtggcg ctttctcata gctcacgctg taggtatctc agttcggtgt aggtcgttcg     2160

ctccaagctg ggctgtgtgc acgaaccccc cgttcagccc gaccgctgcg ccttatccgg     2220

taactatcgt cttgagtcca acccggtaag acacgactta tcgccactgg cagcagccac     2280

tggtaacagg attagcagag cgaggtatgt aggcggtgct acagagttct tgaagtggtg     2340

gcctaactac ggctacacta gaaggacagt atttggtatc tgcgctctgc tgaagccagt     2400

taccttcgga aaaagagttg gtagctcttg atccggcaaa caaaccaccg ctggtagcgg     2460

tggttttttt gtttgcaagc agcagattac gcgcagaaaa aaaggatctc aagaagatcc     2520

tttgatcttt tctacggggt ctgacgctca gtggaacgaa aactcacgtt aagggatttt     2580

ggtcatgaga ttatcaaaaa ggatcttcac ctagatcctt ttaaattaaa aatgaagttt     2640

taaatcaatc taaagtatat atgagtaaac ttggtctgac agttaccaat gcttaatcag     2700

tgaggcacct atctcagcga tctgtctatt tcgttcatcc atagttgcct gactccccgt     2760

cgtgtagata actacgatac gggagggctt accatctggc cccagtgctg caatgatacc     2820

gcgagaccca cgctcaccgg ctccagattt atcagcaata aaccagccag ccggaagggc     2880

cgagcgcaga agtggtcctg caactttatc cgcctccatc cagtctatta attgttgccg     2940

ggaagctaga gtaagtagtt cgccagttaa tagtttgcgc aacgttgttg ccattgctgc     3000

agccatgaga ttatcaaaaa ggatcttcac ctagatcctt ttcacgtaga aagccagtcc     3060

gcagaaacgg tgctgacccc ggatgaatgt cagctactgg gctatctgga caagggaaaa     3120

cgcaagcgca aagagaaagc aggtagcttg cagtgggctt acatggcgat agctagactg     3180

ggcggtttta tggacagcaa gcgaaccgga attgccagct ggggcgccct ctggtaaggt     3240

tgggaagccc tgcaaagtaa actggatggc tttcttgccg ccaaggatct gatggcgcag     3300

gggatcaagc tctgatcaag agacaggatg aggatcgttt cgcatgattg aacaagatgg     3360

attgcacgca ggttctccgg ccgcttgggt ggagaggcta ttcggctatg actgggcaca     3420

acagacaatc ggctgctctg atgccgccgt gttccggctg tcagcgcagg ggcgcccggt     3480

tctttttgtc aagaccgacc tgtccggtgc cctgaatgaa ctgcaagacg aggcagcgcg     3540

gctatcgtgg ctggccacga cgggcgttcc ttgcgcagct gtgctcgacg ttgtcactga     3600

agcgggaagg gactggctgc tattgggcga agtgccgggg caggatctcc tgtcatctca     3660

ccttgctcct gccgagaaag tatccatcat ggctgatgca atgcggcggc tgcatacgct     3720

tgatccggct acctgcccat tcgaccacca agcgaaacat cgcatcgagc gagcacgtac     3780

tcggatggaa gccggtcttg tcgatcagga tgatctggac gaagagcatc aggggctcgc     3840

gccagccgaa ctgttcgcca ggctcaaggc gagcatgccc gacggcgagg atctcgtcgt     3900

gacccatggc gatgcctgct tgccgaatat catggtggaa aatggccgct tttctggatt     3960

catcgactgt ggccggctgg gtgtggcgga ccgctatcag gacatagcgt tggctacccg     4020

tgatattgct gaagagcttg gcggcgaatg ggctgaccgc ttcctcgtgc tttacggtat     4080

cgccgctccc gattcgcagc gcatcgcctt ctatcgcctt cttgacgagt tcttctgaat     4140

tttgttaaaa tttttgttaa atcagctcat tttttaacca ataggccgaa atcggcaaaa     4200

tcccttataa atcaaaagaa tagaccgaga tagggttgag tgttgttcca gtttggaaca     4260

agagtccact attaaagaac gtggactcca acgtcaaagg gcgaaaaacc gtctatcagg     4320

gcgatggccc actacgtgaa ccatcaccct aatcaagttt tttggggtcg aggtgccgta     4380

aagcactaaa tcggaaccct aaagggagcc cccgatttag agcttgacgg ggaaagccgg     4440

cgaacgtggc gagaaaggaa gggaagaaag cgaaaggagc gggcgctagg gcgctggcaa     4500

gtgtagcggt cacgctgcgc gtaaccacca cacccgccgc gcttaatgcg ccgctacagg     4560

gcgcgtccat tcgccattca ggatcgaatt aattcttaat taacatcatc aataatatac     4620

cttattttgg attgaagcca atatgataat gagggggtgg agtttgtgac gtggcgcggg     4680

gcgtgggaac ggggcgggtg acgtagtagt gtggcggaag tgtgatgttg caagtgtggc     4740

ggaacacatg taagcgacgg atgtggcaaa agtgacgttt ttggtgtgcg ccggtgtaca     4800

caggaagtga caattttcgc gcggttttag gcggatgttg tagtaaattt gggcgtaacc     4860

gagtaagatt tggccatttt cgcgggaaaa ctgaataaga ggaagtgaaa tctgaataat     4920

tttgtgttac tcatagcgcg taatactgta atagtaatca attacggggt cattagttca     4980

tagcccatat atggagttcc gcgttacata acttacggta aatggcccgc ctggctgacc     5040

gcccaacgac ccccgcccat tgacgtcaat aatgacgtat gttcccatag taacgccaat     5100

agggactttc cattgacgtc aatgggtgga gtatttacgg taaactgccc acttggcagt     5160

acatcaagtg tatcatatgc caagtacgcc ccctattgac gtcaatgacg gtaaatggcc     5220

cgcctggcat tatgcccagt acatgacctt atgggacttt cctacttggc agtacatcta     5280

cgtattagtc atcgctatta ccatggtgat gcggttttgg cagtacatca atgggcgtgg     5340

atagcggttt gactcacggg gatttccaag tctccacccc attgacgtca atgggagttt     5400

gttttggcac caaaatcaac gggactttcc aaaatgtcgt aacaactccg ccccattgac     5460

gcaaatgggc ggtaggcgtg tacggtggga ggtctatata agcagagctg gtttagtgaa     5520

ccgtcagatc cgctagagat ctggtaccgt cgacgcggcc gctcgagcct aagcttatga     5580

gcagcagtag ttggcttctc ttgagtttgg tggcagtgac agcagcccag agtactatcg     5640

aggagcaggc taaatacttt ctggataagt ttaacgccga ggccgaagac ttgttctatc     5700

aatcttctct cgcttcatgg aattacaata ctaacatcac tgaggagaac gtccagaata     5760

tgaacaatgc tggcgacaaa tggagcgcct tcttgaagga gcagtctacc cttgcacaaa     5820

tgtatccact gcaggagata cagaacctta cagtaaagtt gcagctccag gctctccagc     5880

agaacggatc tagcgtgctt tcagaggata aaagcaaaag gctgaacacc atacttaata     5940

ccatgtccac aatttactct actggtaaag tatgtaaccc cgacaaccct caagaatgcc     6000

tccttcttga gccaggcctc aatgagatca tggctaatag tctggactat aatgaaagac     6060

tgtgggcatg ggagtcctgg agatctgaag tagggaagca actgaggccc ctttatgaag     6120

agtacgtcgt acttaagaat gaaatggccc gcgctaacca ctacgaggat tacggcgatt     6180

actggcgtgg ggactatgaa gtaaatggtg tagatggata cgactatagt cgtgggcaat     6240

tgattgagga tgtggagcac acttttgagg agataaaacc actctatgag catcttcacg     6300

catatgtgag agctaaactg atgaacgcct acccaagtta catcagtcca atcggatgtc     6360

tcccagctca cctccttggc gacatgtggg gaaagttctg gaccaatctg tattccctca     6420

cagtcccttt cgggcaaaag cctaatatag acgtgacaga cgcaatggtt gatcaggctt     6480

gggatgctca aaggattttt aaggaagctg agaagttttt tgtgtcagtc ggtttgccaa     6540

atatgacaca aggcttctgg gaaaatagca tgttgactga tcccggtaat gttcaaaagg     6600

ctgtgtgtca ccctaccgct tgggaccttg ggaaaggtga ctttcgaatc ttgatgtgta     6660

ccaaggtgac aatggatgac tttcttacag cccatcatga aatgggtcac atccagtatg     6720

atatggctta tgcagctcaa cctttcctct tgagaaatgg tgcaaatgaa ggttttcatg     6780

aagctgtagg ggaaataatg tccctgagtg ctgcaacccc aaagcatctc aagagtatcg     6840

gattgttgag cccagatttt caagaagata acgagaccga aatcaacttc cttctgaaac     6900

aagccctcac aatagttggt actcttccat tcacatacat gctggagaaa tggcgttgga     6960

tggtttttaa gggggagata cctaaagatc agtggatgaa aaagtggtgg gagatgaagc     7020

gtgagatcgt aggggtcgtg gagccagtgc ctcatgatga gacttactgt gacccagcat     7080

cactcttcca cgttagcaat gactattcat ttatacgtta ttacactcgc actctttacc     7140

agtttcaatt tcaggaggct ctgtgtcagg ctgccaagca tgagggaccc cttcacaagt     7200

gtgatattag taacagtact gaggcaggcc aaaaactgtt caatatgttg aggcttggca     7260

aaagcgagcc atggactctc gccttggaaa atgttgtcgg ggctaaaaac atgaatgtac     7320

gccctctgct taactatttt gagccccttt ttacatggct caaggaccag aataagaact     7380

cctttgtcgg ctggtcaaca gactggtctc cctatgcaga ccctagtact cctcctactc     7440

cttctccatc aaccccacca actccatccc ctagctgctg tcacccaagg ctgtctctgc     7500

accgacctgc actcgaagac cttctgttgg gctctgaagc taacctgacc tgtactctta     7560

ctggcttgcg cgatgctagc ggcgtgactt tcacctggac acctagtagc ggtaaaagtg     7620

ctgtacaagg acctcctgaa cgcgacctgt gtggttgcta ctctgtgtct tctgtacttc     7680

ccggctgtgc cgagccctgg aatcacggga aaacctttac ctgcaccgcc gcttaccctg     7740

agtcaaaaac tcccctcact gccacattga gtaagtcagg gaatacattc aggccagagg     7800

ttcatttgtt gcctcctcca tctgaagaac ttgctttgaa cgagctggtc actctgacct     7860

gcttggctag gggtttctcc cccaaagatg tacttgtacg gtggttgcag ggcagccaag     7920

agttgccccg cgaaaagtat ttgacctggg cctcaagaca agaacccagc caggggacta     7980

ccacatttgc cgtgaccagt attctgcgtg tagccgctga agattggaag aaaggggata     8040

cattttcttg catggtaggg catgaggccc ttcccctcgc tttcactcag aagacaatag     8100

acagactcgc cggaaagcct actcacgtga atgttagcgt agtcatggct gaggttgacg     8160

gaacttgcta ctgagatatc cgatccaccg gatctagata actgatcata atcagccata     8220

ccacatttgt agaggtttta cttgctttaa aaaacctccc acacctcccc ctgaacctga     8280

aacataaaat gaatgcaatt gttgttgtta acttgtttat tgcagcttat aatggttaca     8340

aataaagcaa tagcatcaca aatttcacaa ataaagcatt tttttcactg cattctagtt     8400

gtggtttgtc caaactcatc aatgtatctt aggtttagtg aaccgtcaga tccgctagcg     8460

ttacataact tacggtaaat ggcccgcctg gctgaccgcc caacgacccc cgcccattga     8520

cgtcaataat gacgtatgtt cccatagtaa cgccaatagg gactttccat tgacgtcaat     8580

gggtggagta tttacggtaa actgcccact tggcagtaca tcaagtgtat catatgccaa     8640

gtacgccccc tattgacgtc aatgacggta aatggcccgc ctggcattat gcccagtaca     8700

tgaccttatg ggactttcct acttggcagt acatctacgt attagtcatc gctattacca     8760

tggtgatgcg gttttggcag tacatcaatg ggcgtggata gcggtttgac tcacggggat     8820

ttccaagtct ccaccccatt gacgtcaatg ggagtttgtt ttggcaccaa aatcaacggg     8880

actttccaaa atgtcgtaac aactccgccc cattgacgca aatgggcggt aggcgtgtac     8940

ggtgggaggt ctatataagc agagctggtt tagtgaaccg tcagatccgc tagagatctg     9000

gtaccgtcga cgcggccgct cgagcctaag cttatgaaga accatctgct tttctgggga     9060

gtacttgccg ttttcataaa agccgtacat gttaaagcac aagaggacga acgcattgtg     9120

ttggttgata ataaatgcaa atgtgctcgg ataacatctc ggatcattcg tagctcagag     9180

gaccccaatg aggatatagt agagcgaaac atcagaatta tagtacccct gaacaacaga     9240

gagaacataa gtgatcccac aagtccattg cggacacgct ttgtttacca tttgtctgat     9300

ctgtgtaaaa aatgtgatcc aacagaggtg gaactcgaca atcagatcgt caccgccacc     9360

cagtctaaca tctgcgatga agattcagct acagagacat gctacacata cgaccggaac     9420

aagtgctata ctgccgttgt gccactcgtt tacggtggag aaacaaagat ggttgaaact     9480

gcacttacac cagatgcctg ctatccagat tgagatatcc gatccaccgg atctagataa     9540

ctgatcataa tcagccatac cacatttgta gaggttttac ttgctttaaa aaacctccca     9600

cacctccccc tgaacctgaa acataaaatg aatgcaattg ttgttgttaa cttgtttatt     9660

gcagcttata atggttacaa ataaagcaat agcatcacaa atttcacaaa taaagcattt     9720

ttttcactgc attctagttg tggtttgtcc aaactcatca atgtatctta acgcggatct     9780

gggcgtggtt aagggtggga aagaatatat aaggtggggg tcttatgtag ttttgtatct     9840

gttttgcagc agccgccgcc gccatgagca ccaactcgtt tgatggaagc attgtgagct     9900

catatttgac aacgcgcatg cccccatggg ccggggtgcg tcagaatgtg atgggctcca     9960

gcattgatgg tcgccccgtc ctgcccgcaa actctactac cttgacctac gagaccgtgt    10020

ctggaacgcc gttggagact gcagcctccg ccgccgcttc agccgctgca gccaccgccc    10080

gcgggattgt gactgacttt gctttcctga gcccgcttgc aagcagtgca gcttcccgtt    10140

catccgcccg cgatgacaag ttgacggctc ttttggcaca attggattct ttgacccggg    10200

aacttaatgt cgtttctcag cagctgttgg atctgcgcca gcaggtttct gccctgaagg    10260

cttcctcccc tcccaatgcg gtttaaaaca taaataaaaa accagactct gtttggattt    10320

ggatcaagca agtgtcttgc tgtctttatt taggggtttt gcgcgcgcgg taggcccggg    10380

accagcggtc tcggtcgttg agggtcctgt gtattttttc caggacgtgg taaaggtgac    10440

tctggatgtt cagatacatg ggcataagcc cgtctctggg gtggaggtag caccactgca    10500

gagcttcatg ctgcggggtg gtgttgtaga tgatccagtc gtagcaggag cgctgggcgt    10560

ggtgcctaaa aatgtctttc agtagcaagc tgattgccag gggcaggccc ttggtgtaag    10620

tgtttacaaa gcggttaagc tgggatgggt gcatacgtgg ggatatgaga tgcatcttgg    10680

actgtatttt taggttggct atgttcccag ccatatccct ccggggattc atgttgtgca    10740

gaaccaccag cacagtgtat ccggtgcact tgggaaattt gtcatgtagc ttagaaggaa    10800

atgcgtggaa gaacttggag acgcccttgt gacctccaag attttccatg cattcgtcca    10860

taatgatggc aatgggccca cgggcggcgg cctgggcgaa gatatttctg ggatcactaa    10920

cgtcatagtt gtgttccagg atgagatcgt cataggccat ttttacaaag cgcgggcgga    10980

gggtgccaga ctgcggtata atggttccat ccggcccagg ggcgtagtta ccctcacaga    11040

tttgcatttc ccacgctttg agttcagatg gggggatcat gtctacctgc ggggcgatga    11100

agaaaacggt ttccggggta ggggagatca gctgggaaga aagcaggttc ctgagcagct    11160

gcgacttacc gcagccggtg ggcccgtaaa tcacacctat taccggctgc aactggtagt    11220

taagagagct gcagctgccg tcatccctga gcaggggggc cacttcgtta agcatgtccc    11280

tgactcgcat gttttccctg accaaatccg ccagaaggcg ctcgccgccc agcgatagca    11340

gttcttgcaa ggaagcaaag tttttcaacg gtttgagacc gtccgccgta ggcatgcttt    11400

tgagcgtttg accaagcagt tccaggcggt cccacagctc ggtcacctgc tctacggcat    11460

ctcgatccag catatctcct cgtttcgcgg gttggggcgg ctttcgctgt acggcagtag    11520

tcggtgctcg tccagacggg ccagggtcat gtctttccac gggcgcaggg tcctcgtcag    11580

cgtagtctgg gtcacggtga aggggtgcgc tccgggctgc gcgctggcca gggtgcgctt    11640

gaggctggtc ctgctggtgc tgaagcgctg ccggtcttcg ccctgcgcgt cggccaggta    11700

gcatttgacc atggtgtcat agtccagccc ctccgcggcg tggcccttgg cgcgcagctt    11760

gcccttggag gaggcgccgc acgaggggca gtgcagactt ttgagggcgt agagcttggg    11820

cgcgagaaat accgattccg gggagtaggc atccgcgccg caggccccgc agacggtctc    11880

gcattccacg agccaggtga gctctggccg ttcggggtca aaaaccaggt ttcccccatg    11940

ctttttgatg cgtttcttac ctctggtttc catgagccgg tgtccacgct cggtgacgaa    12000

aaggctgtcc gtgtccccgt atacagactt gagaggcctg tcctcgagcg gtgttccgcg    12060

gtcctcctcg tatagaaact cggaccactc tgagacaaag gctcgcgtcc aggccagcac    12120

gaaggaggct aagtgggagg ggtagcggtc gttgtccact agggggtcca ctcgctccag    12180

ggtgtgaaga cacatgtcgc cctcttcggc atcaaggaag gtgattggtt tgtaggtgta    12240

ggccacgtga ccgggtgttc ctgaaggggg gctataaaag ggggtggggg cgcgttcgtc    12300

ctcactctct tccgcatcgc tgtctgcgag ggccagctgt tggggtgagt actccctctg    12360

aaaagcgggc atgacttctg cgctaagatt gtcagtttcc aaaaacgagg aggatttgat    12420

attcacctgg cccgcggtga tgcctttgag ggtggccgca tccatctggt cagaaaagac    12480

aatctttttg ttgtcaagct tggtggcaaa cgacccgtag agggcgttgg acagcaactt    12540

ggcgatggag cgcagggttt ggtttttgtc gcgatcggcg cgctccttgg ccgcgatgtt    12600

tagctgcacg tattcgcgcg caacgcaccg ccattcggga aagacggtgg tgcgctcgtc    12660

gggcaccagg tgcacgcgcc aaccgcggtt gtgcagggtg acaaggtcaa cgctggtggc    12720

tacctctccg cgtaggcgct cgttggtcca gcagaggcgg ccgcccttgc gcgagcagaa    12780

tggcggtagg gggtctagct gcgtctcgtc cggggggtct gcgtccacgg taaagacccc    12840

gggcagcagg cgcgcgtcga agtagtctat cttgcatcct tgcaagtcta gcgcctgctg    12900

ccatgcgcgg gcggcaagcg cgcgctcgta tgggttgagt gggggacccc atggcatggg    12960

gtgggtgagc gcggaggcgt acatgccgca aatgtcgtaa acgtagaggg gctctctgag    13020

tattccaaga tatgtagggt agcatcttcc accgcggatg ctggcgcgca cgtaatcgta    13080

tagttcgtgc gagggagcga ggaggtcggg accgaggttg ctacgggcgg gctgctctgc    13140

tcggaagact atctgcctga agatggcatg tgagttggat gatatggttg gacgctggaa    13200

gacgttgaag ctggcgtctg tgagacctac cgcgtcacgc acgaaggagg cgtaggagtc    13260

gcgcagcttg ttgaccagct cggcggtgac ctgcacgtct agggcgcagt agtccagggt    13320

ttccttgatg atgtcatact tatcctgtcc cttttttttc cacagctcgc ggttgaggac    13380

aaactcttcg cggtctttcc agtactcttg gatcggaaac ccgtcggcct ccgaacggta    13440

agagcctagc atgtagaact ggttgacggc ctggtaggcg cagcatccct tttctacggg    13500

tagcgcgtat gcctgcgcgg ccttccggca tgaccagcat gaagggcacg agctgcttcc    13560

caaaggcccc catccaagta taggtctcta catcgtaggt gacaaagaga cgctcggtgc    13620

gaggatgcga gccgatcggg aagaactgga tctcccgcca ccaattggag gagtggctat    13680

tgatgtggtg aaagtagaag tccctgcgac gggccgaaca ctcgtgctgg cttttgtaaa    13740

aacgtgcgca gtactggcag cggtgcacgg gctgtacatc ctgcacgagg ttgacctgac    13800

gaccgcgcac aaggaagcag agtgggaatt tgagcccctc gcctggcggg tttggctggt    13860

ggtcttctac ttcggctgct tgtccttgac cgtctggctg ctcgagggga gttacggtgg    13920

atcggaccac cacgccgcgc gagcccaaag tccagatgtc cgcgcgcggc ggtcggagct    13980

tgatgacaac atcgcgcaga tgggagctgt ccatggtctg gagctcccgc ggcgtcaggt    14040

caggcgggag ctcctgcagg tttacctcgc atagacgggt cagggcgcgg gctagatcca    14100

ggtgatacct aatttccagg ggctggttgg tggcggcgtc gatggcttgc aagaggccgc    14160

atccccgcgg cgcgactacg gtaccgcgcg gcgggcggtg ggccgcgggg gtgtccttgg    14220

atgatgcatc taaaagcggt gacgcgggcg agcccccgga ggtagggggg gctccggacc    14280

cgccgggaga gggggcaggg gcacgtcggc gccgcgcgcg ggcaggagct ggtgctgcgc    14340

gcgtaggttg ctggcgaacg cgacgacgcg gcggttgatc tcctgaatct ggcgcctctg    14400

cgtgaagacg acgggcccgg tgagcttgaa cctgaaagag agttcgacag aatcaatttc    14460

ggtgtcgttg acggcggcct ggcgcaaaat ctcctgcacg tctcctgagt tgtcttgata    14520

ggcgatctcg gccatgaact gctcgatctc ttcctcctgg agatctccgc gtccggctcg    14580

ctccacggtg gcggcgaggt cgttggaaat gcgggccatg agctgcgaga aggcgttgag    14640

gcctccctcg ttccagacgc ggctgtagac cacgccccct tcggcatcgc gggcgcgcat    14700

gaccacctgc gcgagattga gctccacgtg ccgggcgaag acggcgtagt ttcgcaggcg    14760

ctgaaagagg tagttgaggg tggtggcggt gtgttctgcc acgaagaagt acataaccca    14820

gcgtcgcaac gtggattcgt tgataattgt tgtgtaggta ctccgccgcc gagggacctg    14880

agcgagtccg catcgaccgg atcggaaaac ctctcgagaa aggcgtctaa ccagtcacag    14940

tcgcaaggta ggctgagcac cgtggcgggc ggcagcgggc ggcggtcggg gttgtttctg    15000

gcggaggtgc tgctgatgat gtaattaaag taggcggtct tgagacggcg gatggtcgac    15060

agaagcacca tgtccttggg tccggcctgc tgaatgcgca ggcggtcggc catgccccag    15120

gcttcgtttt gacatcggcg caggtctttg tagtagtctt gcatgagcct ttctaccggc    15180

acttcttctt ctccttcctc ttgtcctgca tctcttgcat ctatcgctgc ggcggcggcg    15240

gagtttggcc gtaggtggcg ccctcttcct cccatgcgtg tgaccccgaa gcccctcatc    15300

ggctgaagca gggctaggtc ggcgacaacg cgctcggcta atatggcctg ctgcacctgc    15360

gtgagggtag actggaagtc atccatgtcc acaaagcggt ggtatgcgcc cgtgttgatg    15420

gtgtaagtgc agttggccat aacggaccag ttaacggtct ggtgacccgg ctgcgagagc    15480

tcggtgtacc tgagacgcga gtaagccctc gagtcaaata cgtagtcgtt gcaagtccgc    15540

accaggtact ggtatcccac caaaaagtgc ggcggcggct ggcggtagag gggccagcgt    15600

agggtggccg gggctccggg ggcgagatct tccaacataa ggcgatgata tccgtagatg    15660

tacctggaca tccaggtgat gccggcggcg gtggtggagg cgcgcggaaa gtcgcggacg    15720

cggttccaga tgttgcgcag cggcaaaaag tgctccatgg tcgggacgct ctggccggtc    15780

aggcgcgcgc aatcgttgac gctctagcgt gcaaaaggag agcctgtaag cgggcactct    15840

tccgtggtct ggtggataaa ttcgcaaggg tatcatggcg gacgaccggg gttcgagccc    15900

cgtatccggc cgtccgccgt gatccatgcg gttaccgccc gcgtgtcgaa cccaggtgtg    15960

cgacgtcaga caacggggga gtgctccttt tggcttcctt ccaggcgcgg cggctgctgc    16020

gctagctttt ttggccactg gccgcgcgca gcgtaagcgg ttaggctgga aagcgaaagc    16080

attaagtggc tcgctccctg tagccggagg gttattttcc aagggttgag tcgcgggacc    16140

cccggttcga gtctcggacc ggccggactg cggcgaacgg gggtttgcct ccccgtcatg    16200

caagaccccg cttgcaaatt cctccggaaa cagggacgag cccctttttt gcttttccca    16260

gatgcatccg gtgctgcggc agatgcgccc ccctcctcag cagcggcaag agcaagagca    16320

gcggcagaca tgcagggcac cctcccctcc tcctaccgcg tcaggagggg cgacatccgc    16380

ggttgacgcg gcagcagatg gtgattacga acccccgcgg cgccgggccc ggcactacct    16440

ggacttggag gagggcgagg gcctggcgcg gctaggagcg ccctctcctg agcggcaccc    16500

aagggtgcag ctgaagcgtg atacgcgtga ggcgtacgtg ccgcggcaga acctgtttcg    16560

cgaccgcgag ggagaggagc ccgaggagat gcgggatcga aagttccacg cagggcgcga    16620

gctgcggcat ggcctgaatc gcgagcggtt gctgcgcgag gaggactttg agcccgacgc    16680

gcgaaccggg attagtcccg cgcgcgcaca cgtggcggcc gccgacctgg taaccgcata    16740

cgagcagacg gtgaaccagg agattaactt tcaaaaaagc tttaacaacc acgtgcgtac    16800

gcttgtggcg cgcgaggagg tggctatagg actgatgcat ctgtgggact ttgtaagcgc    16860

gctggagcaa aacccaaata gcaagccgct catggcgcag ctgttcctta tagtgcagca    16920

cagcagggac aacgaggcat tcagggatgc gctgctaaac atagtagagc ccgagggccg    16980

ctggctgctc gatttgataa acatcctgca gagcatagtg gtgcaggagc gcagcttgag    17040

cctggctgac aaggtggccg ccatcaacta ttccatgctt agcctgggca agttttacgc    17100

ccgcaagata taccataccc cttacgttcc catagacaag gaggtaaaga tcgaggggtt    17160

ctacatgcgc atggcgctga aggtgcttac cttgagcgac gacctgggcg tttatcgcaa    17220

cgagcgcatc cacaaggccg tgagcgtgag ccggcggcgc gagctcagcg accgcgagct    17280

gatgcacagc ctgcaaaggg ccctggctgg cacgggcagc ggcgatagag aggccgagtc    17340

ctactttgac gcgggcgctg acctgcgctg ggccccaagc cgacgcgccc tggaggcagc    17400

tggggccgga cctgggctgg cggtggcacc cgcgcgcgct ggcaacgtcg gcggcgtgga    17460

ggaatatgac gaggacgatg agtacgagcc agaggacggc gagtactaag cggtgatgtt    17520

tctgatcaga tgatgcaaga cgcaacggac ccggcggtgc gggcggcgct gcagagccag    17580

ccgtccggcc ttaactccac ggacgactgg cgccaggtca tggaccgcat catgtcgctg    17640

actgcgcgca atcctgacgc gttccggcag cagccgcagg ccaaccggct ctccgcaatt    17700

ctggaagcgg tggtcccggc gcgcgcaaac cccacgcacg agaaggtgct ggcgatcgta    17760

aacgcgctgg ccgaaaacag ggccatccgg cccgacgagg ccggcctggt ctacgacgcg    17820

ctgcttcagc gcgtggctcg ttacaacagc ggcaacgtgc agaccaacct ggaccggctg    17880

gtgggggatg tgcgcgaggc cgtggcgcag cgtgagcgcg cgcagcagca gggcaacctg    17940

ggctccatgg ttgcactaaa cgccttcctg agtacacagc ccgccaacgt gccgcgggga    18000

caggaggact acaccaactt tgtgagcgca ctgcggctaa tggtgactga gacaccgcaa    18060

agtgaggtgt accagtctgg gccagactat tttttccaga ccagtagaca aggcctgcag    18120

accgtaaacc tgagccaggc tttcaaaaac ttgcaggggc tgtggggggt gcgggctccc    18180

acaggcgacc gcgcgaccgt gtctagcttg ctgacgccca actcgcgcct gttgctgctg    18240

ctaatagcgc ccttcacgga cagtggcagc gtgtcccggg acacatacct aggtcacttg    18300

ctgacactgt accgcgaggc cataggtcag gcgcatgtgg acgagcatac tttccaggag    18360

attacaagtg tcagccgcgc gctggggcag gaggacacgg gcagcctgga ggcaacccta    18420

aactacctgc tgaccaaccg gcggcagaag atcccctcgt tgcacagttt aaacagcgag    18480

gaggagcgca ttttgcgcta cgtgcagcag agcgtgagcc ttaacctgat gcgcgacggg    18540

gtaacgccca gcgtggcgct ggacatgacc gcgcgcaaca tggaaccggg catgtatgcc    18600

tcaaaccggc cgtttatcaa ccgcctaatg gactacttgc atcgcgcggc cgccgtgaac    18660

cccgagtatt tcaccaatgc catcttgaac ccgcactggc taccgccccc tggtttctac    18720

accgggggat tcgaggtgcc cgagggtaac gatggattcc tctgggacga catagacgac    18780

agcgtgtttt ccccgcaacc gcagaccctg ctagagttgc aacagcgcga gcaggcagag    18840

gcggcgctgc gaaaggaaag cttccgcagg ccaagcagct tgtccgatct aggcgctgcg    18900

gccccgcggt cagatgctag tagcccattt ccaagcttga tagggtctct taccagcact    18960

cgcaccaccc gcccgcgcct gctgggcgag gaggagtacc taaacaactc gctgctgcag    19020

ccgcagcgcg aaaaaaacct gcctccggca tttcccaaca acgggataga gagcctagtg    19080

gacaagatga gtagatggaa gacgtacgcg caggagcaca gggacgtgcc aggcccgcgc    19140

ccgcccaccc gtcgtcaaag gcacgaccgt cagcggggtc tggtgtggga ggacgatgac    19200

tcggcagacg acagcagcgt cctggatttg ggagggagtg gcaacccgtt tgcgcacctt    19260

cgccccaggc tggggagaat gttttaaaaa aaaaaaagca tgatgcaaaa taaaaaactc    19320

accaaggcca tggcaccgag cgttggtttt cttgtattcc ccttagtatg cggcgcgcgg    19380

cgatgtatga ggaaggtcct cctccctcct acgagagtgt ggtgagcgcg gcgccagtgg    19440

cggcggcgct gggttctccc ttcgatgctc ccctggaccc gccgtttgtg cctccgcggt    19500

acctgcggcc taccgggggg agaaacagca tccgttactc tgagttggca cccctattcg    19560

acaccacccg tgtgtacctg gtggacaaca agtcaacgga tgtggcatcc ctgaactacc    19620

agaacgacca cagcaacttt ctgaccacgg tcattcaaaa caatgactac agcccggggg    19680

aggcaagcac acagaccatc aatcttgacg accggtcgca ctggggcggc gacctgaaaa    19740

ccatcctgca taccaacatg ccaaatgtga acgagttcat gtttaccaat aagtttaagg    19800

cgcgggtgat ggtgtcgcgc ttgcctacta aggacaatca ggtggagctg aaatacgagt    19860

gggtggagtt cacgctgccc gagggcaact actccgagac catgaccata gaccttatga    19920

acaacgcgat cgtggagcac tacttgaaag tgggcagaca gaacggggtt ctggaaagcg    19980

acatcggggt aaagtttgac acccgcaact tcagactggg gtttgacccc gtcactggtc    20040

ttgtcatgcc tggggtatat acaaacgaag ccttccatcc agacatcatt ttgctgccag    20100

gatgcggggt ggacttcacc cacagccgcc tgagcaactt gttgggcatc cgcaagcggc    20160

aacccttcca ggagggcttt aggatcacct acgatgatct ggagggtggt aacattcccg    20220

cactgttgga tgtggacgcc taccaggcga gcttgaaaga tgacaccgaa cagggcgggg    20280

gtggcgcagg cggcagcaac agcagtggca gcggcgcgga agagaactcc aacgcggcag    20340

ccgcggcaat gcagccggtg gaggacatga acgatcatgc cattcgcggc gacacctttg    20400

ccacacgggc tgaggagaag cgcgctgagg ccgaagcagc ggccgaagct gccgcccccg    20460

ctgcgcaacc cgaggtcgag aagcctcaga agaaaccggt gatcaaaccc ctgacagagg    20520

acagcaagaa acgcagttac aacctaataa gcaatgacag caccttcacc cagtaccgca    20580

gctggtacct tgcatacaac tacggcgacc ctcagaccgg aatccgctca tggaccctgc    20640

tttgcactcc tgacgtaacc tgcggctcgg agcaggtcta ctggtcgttg ccagacatga    20700

tgcaagaccc cgtgaccttc cgctccacgc gccagatcag caactttccg gtggtgggcg    20760

ccgagctgtt gcccgtgcac tccaagagct tctacaacga ccaggccgtc tactcccaac    20820

tcatccgcca gtttacctct ctgacccacg tgttcaatcg ctttcccgag aaccagattt    20880

tggcgcgccc gccagccccc accatcacca ccgtcagtga aaacgttcct gctctcacag    20940

atcacgggac gctaccgctg cgcaacagca tcggaggagt ccagcgagtg accattactg    21000

acgccagacg ccgcacctgc ccctacgttt acaaggccct gggcatagtc tcgccgcgcg    21060

tcctatcgag ccgcactttt tgagcaagca tgtccatcct tatatcgccc agcaataaca    21120

caggctgggg cctgcgcttc ccaagcaaga tgtttggcgg ggccaagaag cgctccgacc    21180

aacacccagt gcgcgtgcgc gggcactacc gcgcgccctg gggcgcgcac aaacgcggcc    21240

gcactgggcg caccaccgtc gatgacgcca tcgacgcggt ggtggaggag gcgcgcaact    21300

acacgcccac gccgccacca gtgtccacag tggacgcggc cattcagacc gtggtgcgcg    21360

gagcccggcg ctatgctaaa atgaagagac ggcggaggcg cgtagcacgt cgccaccgcc    21420

gccgacccgg cactgccgcc caacgcgcgg cggcggccct gcttaaccgc gcacgtcgca    21480

ccggccgacg ggcggccatg cgggccgctc gaaggctggc cgcgggtatt gtcactgtgc    21540

cccccaggtc caggcgacga gcggccgccg cagcagccgc ggccattagt gctatgactc    21600

agggtcgcag gggcaacgtg tattgggtgc gcgactcggt tagcggcctg cgcgtgcccg    21660

tgcgcacccg ccccccgcgc aactagattg caagaaaaaa ctacttagac tcgtactgtt    21720

gtatgtatcc agcggcggcg gcgcgcaacg aagctatgtc caagcgcaaa atcaaagaag    21780

agatgctcca ggtcatcgcg ccggagatct atggcccccc gaagaaggaa gagcaggatt    21840

acaagccccg aaagctaaag cgggtcaaaa agaaaaagaa agatgatgat gatgaacttg    21900

acgacgaggt ggaactgctg cacgctaccg cgcccaggcg acgggtacag tggaaaggtc    21960

gacgcgtaaa acgtgttttg cgacccggca ccaccgtagt ctttacgccc ggtgagcgct    22020

ccacccgcac ctacaagcgc gtgtatgatg aggtgtacgg cgacgaggac ctgcttgagc    22080

aggccaacga gcgcctcggg gagtttgcct acggaaagcg gcataaggac atgctggcgt    22140

tgccgctgga cgagggcaac ccaacaccta gcctaaagcc cgtaacactg cagcaggtgc    22200

tgcccgcgct tgcaccgtcc gaagaaaagc gcggcctaaa gcgcgagtct ggtgacttgg    22260

cacccaccgt gcagctgatg gtacccaagc gccagcgact ggaagatgtc ttggaaaaaa    22320

tgaccgtgga acctgggctg gagcccgagg tccgcgtgcg gccaatcaag caggtggcgc    22380

cgggactggg cgtgcagacc gtggacgttc agatacccac taccagtagc accagtattg    22440

ccaccgccac agagggcatg gagacacaaa cgtccccggt tgcctcagcg gtggcggatg    22500

ccgcggtgca ggcggtcgct gcggccgcgt ccaagacctc tacggaggtg caaacggacc    22560

cgtggatgtt tcgcgtttca gccccccggc gcccgcgccg ttcgaggaag tacggcgccg    22620

ccagcgcgct actgcccgaa tatgccctac atccttccat tgcgcctacc cccggctatc    22680

gtggctacac ctaccgcccc agaagacgag caactacccg acgccgaacc accactggaa    22740

cccgccgccg ccgtcgccgt cgccagcccg tgctggcccc gatttccgtg cgcagggtgg    22800

ctcgcgaagg aggcaggacc ctggtgctgc caacagcgcg ctaccacccc agcatcgttt    22860

aaaagccggt ctttgtggtt cttgcagata tggccctcac ctgccgcctc cgtttcccgg    22920

tgccgggatt ccgaggaaga atgcaccgta ggaggggcat ggccggccac ggcctgacgg    22980

gcggcatgcg tcgtgcgcac caccggcggc ggcgcgcgtc gcaccgtcgc atgcgcggcg    23040

gtatcctgcc cctccttatt ccactgatcg ccgcggcgat tggcgccgtg cccggaattg    23100

catccgtggc cttgcaggcg cagagacact gattaaaaac aagttgcatg tggaaaaatc    23160

aaaataaaaa gtctggactc tcacgctcgc ttggtcctgt aactattttg tagaatggaa    23220

gacatcaact ttgcgtctct ggccccgcga cacggctcgc gcccgttcat gggaaactgg    23280

caagatatcg gcaccagcaa tatgagcggt ggcgccttca gctggggctc gctgtggagc    23340

ggcattaaaa atttcggttc caccgttaag aactatggca gcaaggcctg gaacagcagc    23400

acaggccaga tgctgaggga taagttgaaa gagcaaaatt tccaacaaaa ggtggtagat    23460

ggcctggcct ctggcattag cggggtggtg gacctggcca accaggcagt gcaaaataag    23520

attaacagta agcttgatcc ccgccctccc gtagaggagc ctccaccggc cgtggagaca    23580

gtgtctccag aggggcgtgg cgaaaagcgt ccgcgccccg acagggaaga aactctggtg    23640

acgcaaatag acgagcctcc ctcgtacgag gaggcactaa agcaaggcct gcccaccacc    23700

cgtcccatcg cgcccatggc taccggagtg ctgggccagc acacacccgt aacgctggac    23760

ctgcctcccc ccgccgacac ccagcagaaa cctgtgctgc caggcccgac cgccgttgtt    23820

gtaacccgtc ctagccgcgc gtccctgcgc cgcgccgcca gcggtccgcg atcgttgcgg    23880

cccgtagcca gtggcaactg gcaaagcaca ctgaacagca tcgtgggtct gggggtgcaa    23940

tccctgaagc gccgacgatg cttctgatag ctaacgtgtc gtatgtgtgt catgtatgcg    24000

tccatgtcgc cgccagagga gctgctgagc cgccgcgcgc ccgctttcca agatggctac    24060

cccttcgatg atgccgcagt ggtcttacat gcacatctcg ggccaggacg cctcggagta    24120

cctgagcccc gggctggtgc agtttgcccg cgccaccgag acgtacttca gcctgaataa    24180

caagtttaga aaccccacgg tggcgcctac gcacgacgtg accacagacc ggtcccagcg    24240

tttgacgctg cggttcatcc ctgtggaccg tgaggatact gcgtactcgt acaaggcgcg    24300

gttcacccta gctgtgggtg ataaccgtgt gctggacatg gcttccacgt actttgacat    24360

ccgcggcgtg ctggacaggg gccctacttt taagccctac tctggcactg cctacaacgc    24420

cctggctccc aagggtgccc caaatccttg cgaatgggat gaagctgcta ctgctcttga    24480

aataaaccta gaagaagagg acgatgacaa cgaagacgaa gtagacgagc aagctgagca    24540

gcaaaaaact cacgtatttg ggcaggcgcc ttattctggt ataaatatta caaaggaggg    24600

tattcaaata ggtgtcgaag gtcaaacacc taaatatgcc gataaaacat ttcaacctga    24660

acctcaaata ggagaatctc agtggtacga aacagaaatt aatcatgcag ctgggagagt    24720

cctaaaaaag actaccccaa tgaaaccatg ttacggttca tatgcaaaac ccacaaatga    24780

aaatggaggg caaggcattc ttgtaaagca acaaaatgga aagctagaaa gtcaagtgga    24840

aatgcaattt ttctcaacta ctgaggcagc cgcaggcaat ggtgataact tgactcctaa    24900

agtggtattg tacagtgaag atgtagatat agaaacccca gacactcata tttcttacat    24960

gcccactatt aaggaaggta actcacgaga actaatgggc caacaatcta tgcccaacag    25020

gcctaattac attgctttta gggacaattt tattggtcta atgtattaca acagcacggg    25080

taatatgggt gttctggcgg gccaagcatc gcagttgaat gctgttgtag atttgcaaga    25140

cagaaacaca gagctttcat accagctttt gcttgattcc attggtgata gaaccaggta    25200

cttttctatg tggaatcagg ctgttgacag ctatgatcca gatgttagaa ttattgaaaa    25260

tcatggaact gaagatgaac ttccaaatta ctgctttcca ctgggaggtg tgattaatac    25320

agagactctt accaaggtaa aacctaaaac aggtcaggaa aatggatggg aaaaagatgc    25380

tacagaattt tcagataaaa atgaaataag agttggaaat aattttgcca tggaaatcaa    25440

tctaaatgcc aacctgtgga gaaatttcct gtactccaac atagcgctgt atttgcccga    25500

caagctaaag tacagtcctt ccaacgtaaa aatttctgat aacccaaaca cctacgacta    25560

catgaacaag cgagtggtgg ctcccgggct agtggactgc tacattaacc ttggagcacg    25620

ctggtccctt gactatatgg acaacgtcaa cccatttaac caccaccgca atgctggcct    25680

gcgctaccgc tcaatgttgc tgggcaatgg tcgctatgtg cccttccaca tccaggtgcc    25740

tcagaagttc tttgccatta aaaacctcct tctcctgccg ggctcataca cctacgagtg    25800

gaacttcagg aaggatgtta acatggttct gcagagctcc ctaggaaatg acctaagggt    25860

tgacggagcc agcattaagt ttgatagcat ttgcctttac gccaccttct tccccatggc    25920

ccacaacacc gcctccacgc ttgaggccat gcttagaaac gacaccaacg accagtcctt    25980

taacgactat ctctccgccg ccaacatgct ctaccctata cccgccaacg ctaccaacgt    26040

gcccatatcc atcccctccc gcaactgggc ggctttccgc ggctgggcct tcacgcgcct    26100

taagactaag gaaaccccat cactgggctc gggctacgac ccttattaca cctactctgg    26160

ctctataccc tacctagatg gaacctttta cctcaaccac acctttaaga aggtggccat    26220

tacctttgac tcttctgtca gctggcctgg caatgaccgc ctgcttaccc ccaacgagtt    26280

tgaaattaag cgctcagttg acggggaggg ttacaacgtt gcccagtgta acatgaccaa    26340

agactggttc ctggtacaaa tgctagctaa ctataacatt ggctaccagg gcttctatat    26400

cccagagagc tacaaggacc gcatgtactc cttctttaga aacttccagc ccatgagccg    26460

tcaggtggtg gatgatacta aatacaagga ctaccaacag gtgggcatcc tacaccaaca    26520

caacaactct ggatttgttg gctaccttgc ccccaccatg cgcgaaggac aggcctaccc    26580

tgctaacttc ccctatccgc ttataggcaa gaccgcagtt gacagcatta cccagaaaaa    26640

gtttctttgc gatcgcaccc tttggcgcat cccattctcc agtaacttta tgtccatggg    26700

cgcactcaca gacctgggcc aaaaccttct ctacgccaac tccgcccacg cgctagacat    26760

gacttttgag gtggatccca tggacgagcc cacccttctt tatgttttgt ttgaagtctt    26820

tgacgtggtc cgtgtgcacc agccgcaccg cggcgtcatc gaaaccgtgt acctgcgcac    26880

gcccttctcg gccggcaacg ccacaacata aagaagcaag caacatcaac aacagctgcc    26940

gccatgggct ccagtgagca ggaactgaaa gccattgtca aagatcttgg ttgtgggcca    27000

tattttttgg gcacctatga caagcgcttt ccaggctttg tttctccaca caagctcgcc    27060

tgcgccatag tcaatacggc cggtcgcgag actgggggcg tacactggat ggcctttgcc    27120

tggaacccgc actcaaaaac atgctacctc tttgagccct ttggcttttc tgaccagcga    27180

ctcaagcagg tttaccagtt tgagtacgag tcactcctgc gccgtagcgc cattgcttct    27240

tcccccgacc gctgtataac gctggaaaag tccacccaaa gcgtacaggg gcccaactcg    27300

gccgcctgtg gactattctg ctgcatgttt ctccacgcct ttgccaactg gccccaaact    27360

cccatggatc acaaccccac catgaacctt attaccgggg tacccaactc catgctcaac    27420

agtccccagg tacagcccac cctgcgtcgc aaccaggaac agctctacag cttcctggag    27480

cgccactcgc cctacttccg cagccacagt gcgcagatta ggagcgccac ttctttttgt    27540

cacttgaaaa acatgtaaaa ataatgtact agagacactt tcaataaagg caaatgcttt    27600

tatttgtaca ctctcgggtg attatttacc cccacccttg ccgtctgcgc cgtttaaaaa    27660

tcaaaggggt tctgccgcgc atcgctatgc gccactggca gggacacgtt gcgatactgg    27720

tgtttagtgc tccacttaaa ctcaggcaca accatccgcg gcagctcggt gaagttttca    27780

ctccacaggc tgcgcaccat caccaacgcg tttagcaggt cgggcgccga tatcttgaag    27840

tcgcagttgg ggcctccgcc ctgcgcgcgc gagttgcgat acacagggtt gcagcactgg    27900

aacactatca gcgccgggtg gtgcacgctg gccagcacgc tcttgtcgga gatcagatcc    27960

gcgtccaggt cctccgcgtt gctcagggcg aacggagtca actttggtag ctgccttccc    28020

aaaaagggcg cgtgcccagg ctttgagttg cactcgcacc gtagtggcat caaaaggtga    28080

ccgtgcccgg tctgggcgtt aggatacagc gcctgcataa aagccttgat ctgcttaaaa    28140

gccacctgag cctttgcgcc ttcagagaag aacatgccgc aagacttgcc ggaaaactga    28200

ttggccggac aggccgcgtc gtgcacgcag caccttgcgt cggtgttgga gatctgcacc    28260

acatttcggc cccaccggtt cttcacgatc ttggccttgc tagactgctc cttcagcgcg    28320

cgctgcccgt tttcgctcgt cacatccatt tcaatcacgt gctccttatt tatcataatg    28380

cttccgtgta gacacttaag ctcgccttcg atctcagcgc agcggtgcag ccacaacgcg    28440

cagcccgtgg gctcgtgatg cttgtaggtc acctctgcaa acgactgcag gtacgcctgc    28500

aggaatcgcc ccatcatcgt cacaaaggtc ttgttgctgg tgaaggtcag ctgcaacccg    28560

cggtgctcct cgttcagcca ggtcttgcat acggccgcca gagcttccac ttggtcaggc    28620

agtagtttga agttcgcctt tagatcgtta tccacgtggt acttgtccat cagcgcgcgc    28680

gcagcctcca tgcccttctc ccacgcagac acgatcggca cactcagcgg gttcatcacc    28740

gtaatttcac tttccgcttc gctgggctct tcctcttcct cttgcgtccg cataccacgc    28800

gccactgggt cgtcttcatt cagccgccgc actgtgcgct tacctccttt gccatgcttg    28860

attagcaccg gtgggttgct gaaacccacc atttgtagcg ccacatcttc tctttcttcc    28920

tcgctgtcca cgattacctc tggtgatggc gggcgctcgg gcttgggaga agggcgcttc    28980

tttttcttct tgggcgcaat ggccaaatcc gccgccgagg tcgatggccg cgggctgggt    29040

gtgcgcggca ccagcgcgtc ttgtgatgag tcttcctcgt cctcggactc gatacgccgc    29100

ctcatccgct tttttggggg cgcccgggga ggcggcggcg acggggacgg ggacgacacg    29160

tcctccatgg ttgggggacg tcgcgccgca ccgcgtccgc gctcgggggt ggtttcgcgc    29220

tgctcctctt cccgactggc catttccttc tcctataggc agaaaaagat catggagtca    29280

gtcgagaaga aggacagcct aaccgccccc tctgagttcg ccaccaccgc ctccaccgat    29340

gccgccaacg cgcctaccac cttccccgtc gaggcacccc cgcttgagga ggaggaagtg    29400

attatcgagc aggacccagg ttttgtaagc gaagacgacg aggaccgctc agtaccaaca    29460

gaggataaaa agcaagacca ggacaacgca gaggcaaacg aggaacaagt cgggcggggg    29520

gacgaaaggc atggcgacta cctagatgtg ggagacgacg tgctgttgaa gcatctgcag    29580

cgccagtgcg ccattatctg cgacgcgttg caagagcgca gcgatgtgcc cctcgccata    29640

gcggatgtca gccttgccta cgaacgccac ctattctcac cgcgcgtacc ccccaaacgc    29700

caagaaaacg gcacatgcga gcccaacccg cgcctcaact tctaccccgt atttgccgtg    29760

ccagaggtgc ttgccaccta tcacatcttt ttccaaaact gcaagatacc cctatcctgc    29820

cgtgccaacc gcagccgagc ggacaagcag ctggccttgc ggcagggcgc tgtcatacct    29880

gatatcgcct cgctcaacga agtgccaaaa atctttgagg gtcttggacg cgacgagaag    29940

cgcgcggcaa acgctctgca acaggaaaac agcgaaaatg aaagtcactc tggagtgttg    30000

gtggaactcg agggtgacaa cgcgcgccta gccgtactaa aacgcagcat cgaggtcacc    30060

cactttgcct acccggcact taacctaccc cccaaggtca tgagcacagt catgagtgag    30120

ctgatcgtgc gccgtgcgca gcccctggag agggatgcaa atttgcaaga acaaacagag    30180

gagggcctac ccgcagttgg cgacgagcag ctagcgcgct ggcttcaaac gcgcgagcct    30240

gccgacttgg aggagcgacg caaactaatg atggccgcag tgctcgttac cgtggagctt    30300

gagtgcatgc agcggttctt tgctgacccg gagatgcagc gcaagctaga ggaaacattg    30360

cactacacct ttcgacaggg ctacgtacgc caggcctgca agatctccaa cgtggagctc    30420

tgcaacctgg tctcctacct tggaattttg cacgaaaacc gccttgggca aaacgtgctt    30480

cattccacgc tcaagggcga ggcgcgccgc gactacgtcc gcgactgcgt ttacttattt    30540

ctatgctaca cctggcagac ggccatgggc gtttggcagc agtgcttgga ggagtgcaac    30600

ctcaaggagc tgcagaaact gctaaagcaa aacttgaagg acctatggac ggccttcaac    30660

gagcgctccg tggccgcgca cctggcggac atcattttcc ccgaacgcct gcttaaaacc    30720

ctgcaacagg gtctgccaga cttcaccagt caaagcatgt tgcagaactt taggaacttt    30780

atcctagagc gctcaggaat cttgcccgcc acctgctgtg cacttcctag cgactttgtg    30840

cccattaagt accgcgaatg ccctccgccg ctttggggcc actgctacct tctgcagcta    30900

gccaactacc ttgcctacca ctctgacata atggaagacg tgagcggtga cggtctactg    30960

gagtgtcact gtcgctgcaa cctatgcacc ccgcaccgct ccctggtttg caattcgcag    31020

ctgcttaacg aaagtcaaat tatcggtacc tttgagctgc agggtccctc gcctgacgaa    31080

aagtccgcgg ctccggggtt gaaactcact ccggggctgt ggacgtcggc ttaccttcgc    31140

aaatttgtac ctgaggacta ccacgcccac gagattaggt tctacgaaga ccaatcccgc    31200

ccgcctaatg cggagcttac cgcctgcgtc attacccagg gccacattct tggccaattg    31260

caagccatca acaaagcccg ccaagagttt ctgctacgaa agggacgggg ggtttacttg    31320

gacccccagt ccggcgagga gctcaaccca atccccccgc cgccgcagcc ctatcagcag    31380

cagccgcggg cccttgcttc ccaggatggc acccaaaaag aagctgcagc tgccgccgcc    31440

acccacggac gaggaggaat actgggacag tcaggcagag gaggttttgg acgaggagga    31500

ggaggacatg atggaagact gggagagcct agacgaggaa gcttccgagg tcgaagaggt    31560

gtcagacgaa acaccgtcac cctcggtcgc attcccctcg ccggcgcccc agaaatcggc    31620

aaccggttcc agcatggcta caacctccgc tcctcaggcg ccgccggcac tgcccgttcg    31680

ccgacccaac cgtagatggg acaccactgg aaccagggcc ggtaagtcca agcagccgcc    31740

gccgttagcc caagagcaac aacagcgcca aggctaccgc tcatggcgcg ggcacaagaa    31800

cgccatagtt gcttgcttgc aagactgtgg gggcaacatc tccttcgccc gccgctttct    31860

tctctaccat cacggcgtgg ccttcccccg taacatcctg cattactacc gtcatctcta    31920

cagcccatac tgcaccggcg gcagcggcag caacagcagc ggccacacag aagcaaaggc    31980

gaccggatag caagactctg acaaagccca agaaatccac agcggcggca gcagcaggag    32040

gaggagcgct gcgtctggcg cccaacgaac ccgtatcgac ccgcgagctt agaaacagga    32100

tttttcccac tctgtatgct atatttcaac agagcagggg ccaagaacaa gagctgaaaa    32160

taaaaaacag gtctctgcga tccctcaccc gcagctgcct gtatcacaaa agcgaagatc    32220

agcttcggcg cacgctggaa gacgcggagg ctctcttcag taaatactgc gcgctgactc    32280

ttaaggacta gtttcgcgcc ctttctcaaa tttaagcgcg aaaactacgt catctccagc    32340

ggccacaccc ggcgccagca cctgttgtca gcgccattat gagcaaggaa attcccacgc    32400

cctacatgtg gagttaccag ccacaaatgg gacttgcggc tggagctgcc caagactact    32460

caacccgaat aaactacatg agcgcgggac cccacatgat atcccgggtc aacggaatac    32520

gcgcccaccg aaaccgaatt ctcctggaac aggcggctat taccaccaca cctcgtaata    32580

accttaatcc ccgtagttgg cccgctgccc tggtgtacca ggaaagtccc gctcccacca    32640

ctgtggtact tcccagagac gcccaggccg aagttcagat gactaactca ggggcgcagc    32700

ttgcgggcgg ctttcgtcac agggtgcggt cgcccgggca gggtataact cacctgacaa    32760

tcagagggcg aggtattcag ctcaacgacg agtcggtgag ctcctcgctt ggtctccgtc    32820

cggacgggac atttcagatc ggcggcgccg gccgctcttc attcacgcct cgtcaggcaa    32880

tcctaactct gcagacctcg tcctctgagc cgcgctctgg aggcattgga actctgcaat    32940

ttattgagga gtttgtgcca tcggtctact ttaacccctt ctcgggacct cccggccact    33000

atccggatca atttattcct aactttgacg cggtaaagga ctcggcggac ggctacgact    33060

gaatgttaag tggagaggca gagcaactgc gcctgaaaca cctggtccac tgtcgccgcc    33120

acaagtgctt tgcccgcgac tccggtgagt tttgctactt tgaattgccc gaggatcata    33180

tcgagggccc ggcgcacggc gtccggctta ccgcccaggg agagcttgcc cgtagcctga    33240

ttcgggagtt tacccagcgc cccctgctag ttgagcggga caggggaccc tgtgttctca    33300

ctgtgatttg caactgtcct aaccctggat tacatcaaga tcctctagtt aatgtcaggt    33360

cgcctaagtc gattaactag agtacccggg gatcttattc cctttaacta ataaaaaaaa    33420

ataataaagc atcacttact taaaatcagt tagcaaattt ctgtccagtt tattcagcag    33480

cacctccttg ccctcctccc agctctggta ttgcagcttc ctcctggctg caaactttct    33540

ccacaatcta aatggaatgt cagtttcctc ctgttcctgt ccatccgcac ccactatctt    33600

catgttgttg cagatgaagc gcgcaagacc gtctgaagat accttcaacc ccgtgtatcc    33660

atatgacacg gaaaccggtc ctccaactgt gccttttctt actcctccct ttgtatcccc    33720

caatgggttt caagagagtc cccctggggt actctctttg cgcctatccg aacctctagt    33780

tacctccaat ggcatgcttg cgctcaaaat gggcaacggc ctctctctgg acgaggccgg    33840

caaccttacc tcccaaaatg taaccactgt gagcccacct ctcaaaaaaa ccaagtcaaa    33900

cataaacctg gaaatatctg cacccctcac agttacctca gaagccctaa ctgtggctgc    33960

cgccgcacct ctaatggtcg cgggcaacac actcaccatg caatcacagg ccccgctaac    34020

cgtgcacgac tccaaactta gcattgccac ccaaggaccc ctcacagtgt cagaaggaaa    34080

gctagccctg caaacatcag gccccctcac caccaccgat agcagtaccc ttactatcac    34140

tgcctcaccc cctctaacta ctgccactgg tagcttgggc attgacttga aagagcccat    34200

ttatacacaa aatggaaaac taggactaaa gtacggggct cctttgcatg taacagacga    34260

cctaaacact ttgaccgtag caactggtcc aggtgtgact attaataata cttccttgca    34320

aactaaagtt actggagcct tgggttttga ttcacaaggc aatatgcaac ttaatgtagc    34380

aggaggacta aggattgatt ctcaaaacag acgccttata cttgatgtta gttatccgtt    34440

tgatgctcaa aaccaactaa atctaagact aggacagggc cctcttttta taaactcagc    34500

ccacaacttg gatattaact acaacaaagg cctttacttg tttacagctt caaacaattc    34560

caaaaagctt gaggttaacc taagcactgc caaggggttg atgtttgacg ctacagccat    34620

agccattaat gcaggagatg ggcttgaatt tggttcacct aatgcaccaa acacaaatcc    34680

cctcaaaaca aaaattggcc atggcctaga atttgattca aacaaggcta tggttcctaa    34740

actaggaact ggccttagtt ttgacagcac aggtgccatt acagtaggaa acaaaaataa    34800

tgataagcta actttgtgga ccacaccagc tccatctcct aactgtagac taaatgcaga    34860

gaaagatgct aaactcactt tggtcttaac aaaatgtggc agtcaaatac ttgctacagt    34920

ttcagttttg gctgttaaag gcagtttggc tccaatatct ggaacagttc aaagtgctca    34980

tcttattata agatttgacg aaaatggagt gctactaaac aattccttcc tggacccaga    35040

atattggaac tttagaaatg gagatcttac tgaaggcaca gcctatacaa acgctgttgg    35100

atttatgcct aacctatcag cttatccaaa atctcacggt aaaactgcca aaagtaacat    35160

tgtcagtcaa gtttacttaa acggagacaa aactaaacct gtaacactaa ccattacact    35220

aaacggtaca caggaaacag gagacacaac tccaagtgca tactctatgt cattttcatg    35280

ggactggtct ggccacaact acattaatga aatatttgcc acatcctctt acactttttc    35340

atacattgcc caagaataaa gaatcgtttg tgttatgttt caacgtgttt atttttcaat    35400

tgcagaaaat ttcaagtcat ttttcattca gtagtatagc cccaccacca catagcttat    35460

acagatcacc gtaccttaat caaactcaca gaaccctagt attcaacctg ccacctccct    35520

cccaacacac agagtacaca gtcctttctc cccggctggc cttaaaaagc atcatatcat    35580

gggtaacaga catattctta ggtgttatat tccacacggt ttcctgtcga gccaaacgct    35640

catcagtgat attaataaac tccccgggca gctcacttaa gttcatgtcg ctgtccagct    35700

gctgagccac aggctgctgt ccaacttgcg gttgcttaac gggcggcgaa ggagaagtcc    35760

acgcctacat gggggtagag tcataatcgt gcatcaggat agggcggtgg tgctgcagca    35820

gcgcgcgaat aaactgctgc cgccgccgct ccgtcctgca ggaatacaac atggcagtgg    35880

tctcctcagc gatgattcgc accgcccgca gcataaggcg ccttgtcctc cgggcacagc    35940

agcgcaccct gatctcactt aaatcagcac agtaactgca gcacagcacc acaatattgt    36000

tcaaaatccc acagtgcaag gcgctgtatc caaagctcat ggcggggacc acagaaccca    36060

cgtggccatc ataccacaag cgcaggtaga ttaagtggcg acccctcata aacacgctgg    36120

acataaacat tacctctttt ggcatgttgt aattcaccac ctcccggtac catataaacc    36180

tctgattaaa catggcgcca tccaccacca tcctaaacca gctggccaaa acctgcccgc    36240

cggctataca ctgcagggaa ccgggactgg aacaatgaca gtggagagcc caggactcgt    36300

aaccatggat catcatgctc gtcatgatat caatgttggc acaacacagg cacacgtgca    36360

tacacttcct caggattaca agctcctccc gcgttagaac catatcccag ggaacaaccc    36420

attcctgaat cagcgtaaat cccacactgc agggaagacc tcgcacgtaa ctcacgttgt    36480

gcattgtcaa agtgttacat tcgggcagca gcggatgatc ctccagtatg gtagcgcggg    36540

tttctgtctc aaaaggaggt agacgatccc tactgtacgg agtgcgccga gacaaccgag    36600

atcgtgttgg tcgtagtgtc atgccaaatg gaacgccgga cgtagtcata tttcctgaag    36660

caaaaccagg tgcgggcgtg acaaacagat ctgcgtctcc ggtctcgccg cttagatcgc    36720

tctgtgtagt agttgtagta tatccactct ctcaaagcat ccaggcgccc cctggcttcg    36780

ggttctatgt aaactccttc atgcgccgct gccctgataa catccaccac cgcagaataa    36840

gccacaccca gccaacctac acattcgttc tgcgagtcac acacgggagg agcgggaaga    36900

gctggaagaa ccatgttttt ttttttattc caaaagatta tccaaaacct caaaatgaag    36960

atctattaag tgaacgcgct cccctccggt ggcgtggtca aactctacag ccaaagaaca    37020

gataatggca tttgtaagat gttgcacaat ggcttccaaa aggcaaacgg ccctcacgtc    37080

caagtggacg taaaggctaa acccttcagg gtgaatctcc tctataaaca ttccagcacc    37140

ttcaaccatg cccaaataat tctcatctcg ccaccttctc aatatatctc taagcaaatc    37200

ccgaatatta agtccggcca ttgtaaaaat ctgctccaga gcgccctcca ccttcagcct    37260

caagcagcga atcatgattg caaaaattca ggttcctcac agacctgtat aagattcaaa    37320

agcggaacat taacaaaaat accgcgatcc cgtaggtccc ttcgcagggc cagctgaaca    37380

taatcgtgca ggtctgcacg gaccagcgcg gccacttccc cgccaggaac catgacaaaa    37440

gaacccacac tgattatgac acgcatactc ggagctatgc taaccagcgt agccccgatg    37500

taagcttgtt gcatgggcgg cgatataaaa tgcaaggtgc tgctcaaaaa atcaggcaaa    37560

gcctcgcgca aaaaagaaag cacatcgtag tcatgctcat gcagataaag gcaggtaagc    37620

tccggaacca ccacagaaaa agacaccatt tttctctcaa acatgtctgc gggtttctgc    37680

ataaacacaa aataaaataa caaaaaaaca tttaaacatt agaagcctgt cttacaacag    37740

gaaaaacaac ccttataagc ataagacgga ctacggccat gccggcgtga ccgtaaaaaa    37800

actggtcacc gtgattaaaa agcaccaccg acagctcctc ggtcatgtcc ggagtcataa    37860

tgtaagactc ggtaaacaca tcaggttgat tcacatcggt cagtgctaaa aagcgaccga    37920

aatagcccgg gggaatacat acccgcaggc gtagagacaa cattacagcc cccataggag    37980

gtataacaaa attaatagga gagaaaaaca cataaacacc tgaaaaaccc tcctgcctag    38040

gcaaaatagc accctcccgc tccagaacaa catacagcgc ttccacagcg gcagccataa    38100

cagtcagcct taccagtaaa aaagaaaacc tattaaaaaa acaccactcg acacggcacc    38160

agctcaatca gtcacagtgt aaaaaagggc caagtgcaga gcgagtatat ataggactaa    38220

aaaatgacgt aacggttaaa gtccacaaaa aacacccaga aaaccgcacg cgaacctacg    38280

cccagaaacg aaagccaaaa aacccacaac ttcctcaaat cgtcacttcc gttttcccac    38340

gttacgtcac ttcccatttt aagaaaacta caattcccaa cacatacaag ttactccgcc    38400

ctaaaaccta cgtcacccgc cccgttccca cgccccgcgc cacgtcacaa actccacccc    38460

ctcattatca tattggcttc aatccaaaat aaggta                              38496


<210>  221
<211>  9701
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  vector for IgG1 against T27Y H34A R273K ACE2 mutant


<220>
<221>  misc_feature
<222>  (2929)..(2930)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (2934)..(2934)
<223>  n is a, c, g, or t

<400>  221
ggcgtaatct gctgcttgca aacaaaaaaa ccaccgctac cagcggtggt ttgtttgccg       60

gatcaagagc taccaactct ttttccgaag gtaactggct tcagcagagc gcagatacca      120

aatactgtcc ttctagtgta gccgtagtta ggccaccact tcaagaactc tgtagcaccg      180

cctacatacc tcgctctgct gaagccagtt accagtggct gctgccagtg gcgataagtc      240

gtgtcttacc gggttggact caagagatag ttaccggata aggcgcagcg gtcgggctga      300

acggggggtt cgtgcacaca gcccagcttg gagcgaacga cctacaccga actgagatac      360

ctacagcgtg agctatgaga aagcgccacg cttcccgaag ggagaaaggc ggacaggtat      420

ccggtaagcg gcagggtcgg aacaggagag cgcacgaggg agcttccagg gggaaacgcc      480

tggtatcttt atagtcctgt cgggtttcgc cacctctgac ttgagcgtcg atttttgtga      540

tgctcgtcag gggggcggag cctatggaaa aacgccagca acgcaagcta gagtttaaac      600

ttgacagatg agacaataac cctgataaat gcttcaataa tattgaaaaa ggaaaagtat      660

gagtattcaa catttccgtg tcgcccttat tccctttttt gcggcatttt gccttcctgt      720

ttttgctcac ccagaaacgc tggtgaaagt aaaagatgca gaagatcact tgggtgcgcg      780

agtgggttac atcgaactgg atctcaacag cggtaagatc cttgagagtt ttcgccccga      840

agaacgtttc ccaatgatga gcacttttaa agttctgcta tgtggcgcgg tattatcccg      900

tattgatgcc gggcaagagc aactcggtcg ccgcatacac tattctcaga atgacttggt      960

tgaatactca ccagtcacag aaaagcatct tacggatggc atgacagtaa gagaattatg     1020

cagtgctgcc ataaccatga gtgataacac tgcggccaac ttacttctga caactatcgg     1080

aggaccgaag gagctaaccg cttttttgca caacatgggg gatcatgtaa ctcgccttga     1140

tcgttgggaa ccggagctga atgaagccat accaaacgac gagcgtgaca ccacgatgcc     1200

tgtagcaatg gcaacaacgt tgcgaaaact attaactggc gaactactta ctctagcttc     1260

ccggcaacaa ctaatagact ggatggaggc ggataaagtt gcaggaccac ttctgcgctc     1320

ggcacttccg gctggctggt ttattgctga taaatcagga gccggtgagc gtgggtcacg     1380

cggtatcatt gcagcactgg ggccggatgg taagccctcc cgtatcgtag ttatctacac     1440

tacggggagt caggcaacta tggatgaacg aaatagacag atcgctgaga taggtgcctc     1500

actgattaag cattggtaag gataaatttc tggtaaggag gacacgtatg gaagtgggca     1560

agttggggaa gccgtatccg ttgctgaatc tggcatatgt gggagtataa gacgcgcagc     1620

gtcgcatcag gcattttttt ctgcgccaat gcaaaaaggc catccgtcag gatggccttt     1680

cggcataact agggccgccg atatttgaaa atatggcata ttgaaaatgt cgccgatgtg     1740

agtttctgtg taactgatat cgccattttt ccaaaagtga tttttgggca tacgcgatat     1800

ctggcgatag cgcttatatc gtttacgggg gatggcgata gacgactttg gtgacttggg     1860

cgattctgtg tgtcgcaaat atcgcagttt cgatataggt gacagacgat atgaggctat     1920

atcgccgata gaggcgacat caagctggca catggccaat gcatatcgat ctatacattg     1980

aatcaatatt ggccattagc catattattc attggttata tagcataaat caatattggc     2040

tattggccat tgcatacgtt gtatccatat cataatatgt acatttatat tggctcatgt     2100

ccaacattac cgccatgttg acattgatta ttgactagtt attaatagta atcaattacg     2160

gggtcattag ttcatagccc atatatggag ttccgcgtta cataacttac ggtaaatggc     2220

ccgcctggct gaccgcccaa cgacccccgc ccattgacgt caataatgac gtatgttccc     2280

atagtaacgc caatagggac tttccattga cgtcaatggg tggagtattt acggtaaact     2340

gcccacttgg cagtacatca agtgtatcat atgccaagta cgccccctat tgacgtcaat     2400

gacggtaaat ggcccgcctg gcattatgcc cagtacatga ccttatggga ctttcctact     2460

tggcagtaca tctacgtatt agtcatcgct attaccatgg tgatgcggtt ttggcagtac     2520

atcaatgggc gtggatagcg gtttgactca cggggatttc caagtctcca ccccattgac     2580

gtcaatggga gtttgttttg gcaccaaaat caacgggact ttccaaaatg tcgtaacaac     2640

tccgccccat tgacgcaaat gggcggtagg cgtgtacggt gggaggtcta tataagcaga     2700

gctcgtttag tgaaccgtca gatcgcctgg agacgccatc cacgctgttt tgacctccat     2760

agaagacacc gggaccgatc cagcctccgc ggccgggaac ggtgcattgg aacgcggatt     2820

ccccgtgcca agagtgacgt aagtaccgcc tatagagtct ataggcccac ccccttggct     2880

tcttatgcat gctatactgt ttttggcttg gggtctatac accccccgnn ttcntcatgt     2940

tataggtgat ggtatagctt agcctatagg tgtgggttat tgaccattat tgaccactcc     3000

ccctattggt gacgatactt tccattacta atccataaca tggctctttg ccacaactct     3060

ctttattggc tatatgccaa tacactgtcc ttcagagact gacacggact ctgtattttt     3120

acaggatggg gtctcattta ttatttacaa attcacatat acaacaccac cgtccccagt     3180

gcccgcagtt tttattaaac ataacgtggg atctccacgc gaatctcggg tacgtgttcc     3240

ggacatgggc tcttctccgg tagcggcgga gcttctacat ccgagccctg ctcccatgcc     3300

tccagcgact catggtcgct cggcagctcc ttgctcctaa cagtggaggc cagacttagg     3360

cacagcacga tgcccaccac caccagtgtg ccgcacaagg ccgtggcggt agggtatgtg     3420

tctgaaaatg agctcgggga gcgggcttgc accgctgacg catttggaag acttaaggca     3480

gcggcagaag aagatgcagg cagctgagtt gttgtgttct gataagagtc agaggtaact     3540

cccgttgcgg tgctgttaac ggtggagggc agtgtagtct gagcagtact cgttgctgcc     3600

gcgcgcgcca ccagacataa tagctgacag actaacagac tgttcctttc catgggtctt     3660

ttctgcagtc accgtccttg acacgaagct gctagcgcca ccatgagcag cagtagttgg     3720

cttctcttga gtttggtggc agtgacagca gcccagagta ctatcgagga gcaggctaaa     3780

tactttctgg ataagtttaa cgccgaggcc gaagacttgt tctatcaatc ttctctcgct     3840

tcatggaatt acaatactaa catcactgag gagaacgtcc agaatatgaa caatgctggc     3900

gacaaatgga gcgccttctt gaaggagcag tctacccttg cacaaatgta tccactgcag     3960

gagatacaga accttacagt aaagttgcag ctccaggctc tccagcagaa cggatctagc     4020

gtgctttcag aggataaaag caaaaggctg aacaccatac ttaataccat gtccacaatt     4080

tactctactg gtaaagtatg taaccccgac aaccctcaag aatgcctcct tcttgagcca     4140

ggcctcaatg agatcatggc taatagtctg gactataatg aaagactgtg ggcatgggag     4200

tcctggagat ctgaagtagg gaagcaactg aggccccttt atgaagagta cgtcgtactt     4260

aagaatgaaa tggcccgcgc taaccactac gaggattacg gcgattactg gcgtggggac     4320

tatgaagtaa atggtgtaga tggatacgac tatagtcgtg ggcaattgat tgaggatgtg     4380

gagcacactt ttgaggagat aaaaccactc tatgagcatc ttcacgcata tgtgagagct     4440

aaactgatga acgcctaccc aagttacatc agtccaatcg gatgtctccc agctcacctc     4500

cttggcgaca tgtggggaaa gttctggacc aatctgtatt ccctcacagt ccctttcggg     4560

caaaagccta atatagacgt gacagacgca atggttgatc aggcttggga tgctcaaagg     4620

atttttaagg aagctgagaa gttttttgtg tcagtcggtt tgccaaatat gacacaaggc     4680

ttctgggaaa atagcatgtt gactgatccc ggtaatgttc aaaaggctgt gtgtcaccct     4740

accgcttggg accttgggaa aggtgacttt cgaatcttga tgtgtaccaa ggtgacaatg     4800

gatgactttc ttacagccca tcatgaaatg ggtcacatcc agtatgatat ggcttatgca     4860

gctcaacctt tcctcttgag aaatggtgca aatgaaggtt ttcatgaagc tgtaggggaa     4920

ataatgtccc tgagtgctgc aaccccaaag catctcaaga gtatcggatt gttgagccca     4980

gattttcaag aagataacga gaccgaaatc aacttccttc tgaaacaagc cctcacaata     5040

gttggtactc ttccattcac atacatgctg gagaaatggc gttggatggt ttttaagggg     5100

gagataccta aagatcagtg gatgaaaaag tggtgggaga tgaagcgtga gatcgtaggg     5160

gtcgtggagc cagtgcctca tgatgagact tactgtgacc cagcatcact cttccacgtt     5220

agcaatgact attcatttat acgttattac actcgcactc tttaccagtt tcaatttcag     5280

gaggctctgt gtcaggctgc caagcatgag ggaccccttc acaagtgtga tattagtaac     5340

agtactgagg caggccaaaa actgttcaat atgttgaggc ttggcaaaag cgagccatgg     5400

actctcgcct tggaaaatgt tgtcggggct aaaaacatga atgtacgccc tctgcttaac     5460

tattttgagc ccctttttac atggctcaag gaccagaata agaactcctt tgtcggctgg     5520

tcaacagact ggtctcccta tgcagacaaa acacatactt gcccaccttg tcctgcacca     5580

gagctgctgg gaggtccaag cgtgttcctg tttccaccca agcccaaaga cacactgatg     5640

atttctcgaa ctccagaagt gacctgcgtg gtcgtggacg tgagccacga ggatcccgaa     5700

gtgaagttca actggtacgt ggatggcgtg gaggtccata atgctaagac taaaccccgg     5760

gaggaacagt acaacagcac ttatagggtc gtgtccgtgc tgaccgtcct gcatcaggat     5820

tggctgaacg ggaaggaata taagtgcaaa gtgtctaata aggcactgcc cgcccctatc     5880

gagaaaacaa ttagcaaggc taagggtcag cctagagaac cacaggtgta cactctgcct     5940

ccaagtcgcg acgagctgac caagaaccag gtgtcactga catgtctggt caaaggcttt     6000

tatccctcag atatcgcagt ggagtgggaa agcaatggac agcctgagaa caattacaag     6060

accacacccc ctgtgctgga cagtgatggc tcattctttc tgtattctaa gctgacagtg     6120

gacaaaagta ggtggcagca gggaaacgtg ttctcctgct ctgtcatgca cgaagcactg     6180

cacaatcatt atacccagaa gagtctgtca ctgagccctg gcaaatgagc gataccgatt     6240

ctagaactag atcataatca gccataccac atttgtagag gttttacttg ctttaaaaaa     6300

cctcccacac ctccccctga acctgaaaca taaaatgaat gcaattgttg ttgttaactt     6360

gtttattgca gcttataatg gttacaaata aagcaatagc atcacaaatt tcacaaataa     6420

agcatttttt tcactgcatt ctagttgtgg tttgtccaaa ctcatcaatg tatcttaagg     6480

ccgcaggtaa gccagcccag gcctcgccct ccagctcaag gcgggacagg tgccctagag     6540

tagcctgcat ccagggacag gccccagccg ggtgctgaca cgtccacctc catctcttcc     6600

tcaggtctgc ccgggtggca tccctgtgac ccctccccag tgcctctcct ggtcgtggaa     6660

ggtgctactc cagtgcccac cagccttgtc ctaataaaat taagttgcat cattttgttt     6720

gactaggtgt ccttgtataa tattatgggg tggaggcggg tggtatggag caaggggccc     6780

aagttaactt gtttattgca gcttataatg gttacaaata aagcaatagc atcacaaatt     6840

tcacaaataa agcatttttt tcactgcatt ctagttgtgg tttgtccaaa ctcatcaatg     6900

tatcttatca tgtctggatc cgcttcaggc accgggcttg cgggtcatgc accaggtgcg     6960

cggtccttcg ggcacctcga cgtcggcggt gacggtgaag ccgagccgct cgtagaaggg     7020

gaggttgcgg ggcgcggagg tctccaggaa ggcgggcacc ccggcgcgct cggccgcctc     7080

cactccgggg agcacgacgg cgctgcccag acccttgccc tggtggtcgg gcgagacgcc     7140

gacggtggcc aggaaccacg cgggctcctt gggccggtgc ggcgccagga ggccttccat     7200

ctgttgctgc gcggccagcc tggaaccgct caactcggcc atgcgcgggc cgatctcggc     7260

gaacaccgcc cccgcttcga cgctctccgg cgtggtccag accgccaccg cggcgccgtc     7320

gtccgcgacc cacaccttgc cgatgtcgag cccgacgcgc gtgaggaaga gttcttgcag     7380

ctcggtgacc cgctcgatgt ggcggtccgg gtcgacggtg tggcgcgtgg cggggtagtc     7440

ggcgaacgcg gcggcgaggg tgcgtacggc ccgggggacg tcgtcgcggg tggcgaggcg     7500

caccgtgggc ttgtactcgg tcatggtggc ctgcagagtc gctctgtgtt cgaggccaca     7560

cgcgtcacct taatatgcga agtggacctg ggaccgcgcc gccccgactg catctgcgtg     7620

ttttcgccaa tgacaagacg ctgggcgggg tttgtgtcat catagaacta aagacatgca     7680

aatatatttc ttccggggac accgccagca aacgcgagca acgggccacg gggatgaagc     7740

agctgcgcca ctccctgaag atccatcgtc tcctaacaag ttacatcact cctgcccttc     7800

ctcaccctca tctccatcac ctccttcatc tccgtcatct ccgtcatcac cctccgcggc     7860

agccccttcc accataggtg gaaaccaggg aggcaaatct actccatcgt caaagctgca     7920

cacagtcacc ctgatattgc aggtaggagc gggctttgtc ataacaaggt ccttaatcgc     7980

atccttcaaa acctcagcaa atatatgagt ttgtaaaaag accatgaaat aacagacaat     8040

ggactccctt agcgggccag gttgtgggcc gggtccaggg gccattccaa aggggagacg     8100

actcaatggt gtaagacgac attgtggaat agcaagggca gttcctcgcc ttaggttgta     8160

aagggaggtc ttactacctc catatacgaa cacaccggcg acccaagttc cttcgtcggt     8220

agtcctttct acgtgactcc tagccaggag agctcttaaa ccttctgcaa tgttctcaaa     8280

tttcgggttg gaacctcctt gaccacgatg ctttccaaac caccctcctt ttttgcgcct     8340

gcctccatca ccctgacccc cgctgcgcgg gggcacgtca ggctcaccat ctgggccgcc     8400

ttcttggtgg tattcaaaat aatcggcttc ccctacaggg tggaaaaatg gccttctacc     8460

tggagggggc ctgcgcggtg gagacccgga tgatgatgac tgactactgg gactcctggg     8520

cctcttttct ccacgtccac gacctctccc cctggctctt tcacgacttc cccccctggc     8580

tctttcacgt cctctacccc ggcggcctcc actacctcct cgaccccggc ctccactacc     8640

tcctcgaccc cggcctccac tgcctcctcg accccggcct ccacctcctg ctcctgcccc     8700

tcccgctcct gctcctgctc ctgttccacc gtgggtccct ttgcagccaa tgcaacttgg     8760

acgtttttgg ggtctccgga caccatctct atgtcttggc cctgatcctg agccgcccgg     8820

ggctcctggt cttccgcctc ctcgtcctcg tcctcttccc cgtcctcgtc catgtgccat     8880

gatggcggcc tgcagctgtg ttcgaggccg cgcgtgtcac cttaatatgc gaagtggacc     8940

tgggaccgcg ccgccccgac tgcatctgcg tgttcgagtt cgccaatgac aagacgctgg     9000

gcggggagat cccccttatt aaccctaaac gggtagcata tgcttcccgg gtagtagtat     9060

atactatcca gactaaccct aattcaatag catatgttac ccaacgggaa gcatatgcta     9120

tcgaattagg gttagtaaaa gggtcctaag gaacagcgat ctggatagca tatgctatcc     9180

taatctatat ctgggtagca tatgctatcc taatctatat ctgggtagca taggctatcc     9240

taatctatat ctgggtagca tatgctatcc taatctatat ctgggtagta tatgctatcc     9300

taatttatat ctgggtagca taggctatcc taatctatat ctgggtagca tatgctatcc     9360

taatctatat ctgggtagta tatgctatcc taatctgtat ccgggtagca tatgctatcc     9420

tcatgcatat acagtcagca tatgataccc agtagtagag tgggagtgct atcctttgca     9480

tatgccgcca cctcccaagg agatctgtcg acatcgatgg gcgcgggtgt acactccgcc     9540

catcccgccc ctaactccgc ccagttccgc ccattctccg cctcatggct gactaatttt     9600

ttttatttat gcagaggccg aggccgcctc ggcctctgag ctattccaga agtagtgagg     9660

aggctttttt ggaggcctag gcttttgcaa aaagctaatt c                         9701


<210>  222
<211>  38496
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  vector for IgA against T27Y H34A R273L ACE2 mutant

<400>  222
tattattgat gatgttaatt aacatgcatg gatcctacgt ctcgaccgat gcccttgaga       60

gccttcaacc cagtcagctc cttccggtgg gcgcggggca tgactatcgt cgccgcactt      120

atgactgtct tctttatcat gcaactcgta ggacaggtgc cggcagcgct ctgggtcatt      180

ttcggcgagg accgctttcg ctggagcgcg acgatgatcg gcctgtcgct tgcggtattc      240

ggaatcttgc acgccctcgc tcaagccttc gtcactggtc ccgccaccaa acgtttcggc      300

gagaagcagg ccattatcgc cggcatggcg gccgacgcgc tgggctacgt cttgctggcg      360

ttcgcgacgc gaggctggat ggccttcccc attatgattc ttctcgcttc cggcggcatc      420

gggatgcccg cgttgcaggc catgctgtcc aggcaggtag atgacgacca tcagggacag      480

cttcaaggat cgctcgcggc tcttaccagc ctaacttcga tcattggacc gctgatcgtc      540

acggcgattt atgccgcctc ggcgagcaca tggaacgggt tggcatggat tgtaggcgcc      600

gccctatacc ttgtctgcct ccccgcgttg cgtcgcggtg catggagccg ggccacctcg      660

acctgaatgg aagccggcgg cacctcgcta acggattcac cactccaaga attggagcca      720

atcaattctt gcggagaact gtgaatgcgc aaaccaaccc ttggcagaac atatccatcg      780

cgtccgccat ctccagcagc cgcacgcggc gcatctcggg cagcgttggg tcctggccac      840

gggtgcgcat gatcgtgctc ctgtcgttga ggacccggct aggctggcgg ggttgcctta      900

ctggttagca gaatgaatca ccgatacgcg agcgaacgtg aagcgactgc tgctgcaaaa      960

cgtctgcgac ctgagcaaca acatgaatgg tcttcggttt ccgtgtttcg taaagtctgg     1020

aaacgcggaa gtcagcgccc tgcaccatta tgttccggat ctgcatcgca ggatgctgct     1080

ggctaccctg tggaacacct acatctgtat taacgaagcg ctggcattga ccctgagtga     1140

tttttctctg gtcccgccgc atccataccg ccagttgttt accctcacaa cgttccagta     1200

accgggcatg ttcatcatca gtaacccgta tcgtgagcat cctctctcgt ttcatcggta     1260

tcattacccc catgaacaga aatccccctt acacggaggc atcagtgacc aaacaggaaa     1320

aaaccgccct taacatggcc cgctttatca gaagccagac attaacgctt ctggagaaac     1380

tcaacgagct ggacgcggat gaacaggcag acatctgtga atcgcttcac gaccacgctg     1440

atgagcttta ccgcagctgc ctcgcgcgtt tcggtgatga cggtgaaaac ctctgacaca     1500

tgcagctccc ggagacggtc acagcttgtc tgtaagcgga tgccgggagc agacaagccc     1560

gtcagggcgc gtcagcgggt gttggcgggt gtcggggcgc agccatgacc cagtcacgta     1620

gcgatagcgg agtgtatact ggcttaacta tgcggcatca gagcagattg tactgagagt     1680

gcaccatatg cggtgtgaaa taccgcacag atgcgtaagg agaaaatacc gcatcaggcg     1740

ctcttccgct tcctcgctca ctgactcgct gcgctcggtc gttcggctgc ggcgagcggt     1800

atcagctcac tcaaaggcgg taatacggtt atccacagaa tcaggggata acgcaggaaa     1860

gaacatgtga gcaaaaggcc agcaaaaggc caggaaccgt aaaaaggccg cgttgctggc     1920

gtttttccat aggctccgcc cccctgacga gcatcacaaa aatcgacgct caagtcagag     1980

gtggcgaaac ccgacaggac tataaagata ccaggcgttt ccccctggaa gctccctcgt     2040

gcgctctcct gttccgaccc tgccgcttac cggatacctg tccgcctttc tcccttcggg     2100

aagcgtggcg ctttctcata gctcacgctg taggtatctc agttcggtgt aggtcgttcg     2160

ctccaagctg ggctgtgtgc acgaaccccc cgttcagccc gaccgctgcg ccttatccgg     2220

taactatcgt cttgagtcca acccggtaag acacgactta tcgccactgg cagcagccac     2280

tggtaacagg attagcagag cgaggtatgt aggcggtgct acagagttct tgaagtggtg     2340

gcctaactac ggctacacta gaaggacagt atttggtatc tgcgctctgc tgaagccagt     2400

taccttcgga aaaagagttg gtagctcttg atccggcaaa caaaccaccg ctggtagcgg     2460

tggttttttt gtttgcaagc agcagattac gcgcagaaaa aaaggatctc aagaagatcc     2520

tttgatcttt tctacggggt ctgacgctca gtggaacgaa aactcacgtt aagggatttt     2580

ggtcatgaga ttatcaaaaa ggatcttcac ctagatcctt ttaaattaaa aatgaagttt     2640

taaatcaatc taaagtatat atgagtaaac ttggtctgac agttaccaat gcttaatcag     2700

tgaggcacct atctcagcga tctgtctatt tcgttcatcc atagttgcct gactccccgt     2760

cgtgtagata actacgatac gggagggctt accatctggc cccagtgctg caatgatacc     2820

gcgagaccca cgctcaccgg ctccagattt atcagcaata aaccagccag ccggaagggc     2880

cgagcgcaga agtggtcctg caactttatc cgcctccatc cagtctatta attgttgccg     2940

ggaagctaga gtaagtagtt cgccagttaa tagtttgcgc aacgttgttg ccattgctgc     3000

agccatgaga ttatcaaaaa ggatcttcac ctagatcctt ttcacgtaga aagccagtcc     3060

gcagaaacgg tgctgacccc ggatgaatgt cagctactgg gctatctgga caagggaaaa     3120

cgcaagcgca aagagaaagc aggtagcttg cagtgggctt acatggcgat agctagactg     3180

ggcggtttta tggacagcaa gcgaaccgga attgccagct ggggcgccct ctggtaaggt     3240

tgggaagccc tgcaaagtaa actggatggc tttcttgccg ccaaggatct gatggcgcag     3300

gggatcaagc tctgatcaag agacaggatg aggatcgttt cgcatgattg aacaagatgg     3360

attgcacgca ggttctccgg ccgcttgggt ggagaggcta ttcggctatg actgggcaca     3420

acagacaatc ggctgctctg atgccgccgt gttccggctg tcagcgcagg ggcgcccggt     3480

tctttttgtc aagaccgacc tgtccggtgc cctgaatgaa ctgcaagacg aggcagcgcg     3540

gctatcgtgg ctggccacga cgggcgttcc ttgcgcagct gtgctcgacg ttgtcactga     3600

agcgggaagg gactggctgc tattgggcga agtgccgggg caggatctcc tgtcatctca     3660

ccttgctcct gccgagaaag tatccatcat ggctgatgca atgcggcggc tgcatacgct     3720

tgatccggct acctgcccat tcgaccacca agcgaaacat cgcatcgagc gagcacgtac     3780

tcggatggaa gccggtcttg tcgatcagga tgatctggac gaagagcatc aggggctcgc     3840

gccagccgaa ctgttcgcca ggctcaaggc gagcatgccc gacggcgagg atctcgtcgt     3900

gacccatggc gatgcctgct tgccgaatat catggtggaa aatggccgct tttctggatt     3960

catcgactgt ggccggctgg gtgtggcgga ccgctatcag gacatagcgt tggctacccg     4020

tgatattgct gaagagcttg gcggcgaatg ggctgaccgc ttcctcgtgc tttacggtat     4080

cgccgctccc gattcgcagc gcatcgcctt ctatcgcctt cttgacgagt tcttctgaat     4140

tttgttaaaa tttttgttaa atcagctcat tttttaacca ataggccgaa atcggcaaaa     4200

tcccttataa atcaaaagaa tagaccgaga tagggttgag tgttgttcca gtttggaaca     4260

agagtccact attaaagaac gtggactcca acgtcaaagg gcgaaaaacc gtctatcagg     4320

gcgatggccc actacgtgaa ccatcaccct aatcaagttt tttggggtcg aggtgccgta     4380

aagcactaaa tcggaaccct aaagggagcc cccgatttag agcttgacgg ggaaagccgg     4440

cgaacgtggc gagaaaggaa gggaagaaag cgaaaggagc gggcgctagg gcgctggcaa     4500

gtgtagcggt cacgctgcgc gtaaccacca cacccgccgc gcttaatgcg ccgctacagg     4560

gcgcgtccat tcgccattca ggatcgaatt aattcttaat taacatcatc aataatatac     4620

cttattttgg attgaagcca atatgataat gagggggtgg agtttgtgac gtggcgcggg     4680

gcgtgggaac ggggcgggtg acgtagtagt gtggcggaag tgtgatgttg caagtgtggc     4740

ggaacacatg taagcgacgg atgtggcaaa agtgacgttt ttggtgtgcg ccggtgtaca     4800

caggaagtga caattttcgc gcggttttag gcggatgttg tagtaaattt gggcgtaacc     4860

gagtaagatt tggccatttt cgcgggaaaa ctgaataaga ggaagtgaaa tctgaataat     4920

tttgtgttac tcatagcgcg taatactgta atagtaatca attacggggt cattagttca     4980

tagcccatat atggagttcc gcgttacata acttacggta aatggcccgc ctggctgacc     5040

gcccaacgac ccccgcccat tgacgtcaat aatgacgtat gttcccatag taacgccaat     5100

agggactttc cattgacgtc aatgggtgga gtatttacgg taaactgccc acttggcagt     5160

acatcaagtg tatcatatgc caagtacgcc ccctattgac gtcaatgacg gtaaatggcc     5220

cgcctggcat tatgcccagt acatgacctt atgggacttt cctacttggc agtacatcta     5280

cgtattagtc atcgctatta ccatggtgat gcggttttgg cagtacatca atgggcgtgg     5340

atagcggttt gactcacggg gatttccaag tctccacccc attgacgtca atgggagttt     5400

gttttggcac caaaatcaac gggactttcc aaaatgtcgt aacaactccg ccccattgac     5460

gcaaatgggc ggtaggcgtg tacggtggga ggtctatata agcagagctg gtttagtgaa     5520

ccgtcagatc cgctagagat ctggtaccgt cgacgcggcc gctcgagcct aagcttatga     5580

gcagcagtag ttggcttctc ttgagtttgg tggcagtgac agcagcccag agtactatcg     5640

aggagcaggc taaatacttt ctggataagt ttaacgccga ggccgaagac ttgttctatc     5700

aatcttctct cgcttcatgg aattacaata ctaacatcac tgaggagaac gtccagaata     5760

tgaacaatgc tggcgacaaa tggagcgcct tcttgaagga gcagtctacc cttgcacaaa     5820

tgtatccact gcaggagata cagaacctta cagtaaagtt gcagctccag gctctccagc     5880

agaacggatc tagcgtgctt tcagaggata aaagcaaaag gctgaacacc atacttaata     5940

ccatgtccac aatttactct actggtaaag tatgtaaccc cgacaaccct caagaatgcc     6000

tccttcttga gccaggcctc aatgagatca tggctaatag tctggactat aatgaaagac     6060

tgtgggcatg ggagtcctgg agatctgaag tagggaagca actgaggccc ctttatgaag     6120

agtacgtcgt acttaagaat gaaatggccc gcgctaacca ctacgaggat tacggcgatt     6180

actggcgtgg ggactatgaa gtaaatggtg tagatggata cgactatagt cgtgggcaat     6240

tgattgagga tgtggagcac acttttgagg agataaaacc actctatgag catcttcacg     6300

catatgtgag agctaaactg atgaacgcct acccaagtta catcagtcca atcggatgtc     6360

tcccagctca cctccttggc gacatgtggg gactgttctg gaccaatctg tattccctca     6420

cagtcccttt cgggcaaaag cctaatatag acgtgacaga cgcaatggtt gatcaggctt     6480

gggatgctca aaggattttt aaggaagctg agaagttttt tgtgtcagtc ggtttgccaa     6540

atatgacaca aggcttctgg gaaaatagca tgttgactga tcccggtaat gttcaaaagg     6600

ctgtgtgtca ccctaccgct tgggaccttg ggaaaggtga ctttcgaatc ttgatgtgta     6660

ccaaggtgac aatggatgac tttcttacag cccatcatga aatgggtcac atccagtatg     6720

atatggctta tgcagctcaa cctttcctct tgagaaatgg tgcaaatgaa ggttttcatg     6780

aagctgtagg ggaaataatg tccctgagtg ctgcaacccc aaagcatctc aagagtatcg     6840

gattgttgag cccagatttt caagaagata acgagaccga aatcaacttc cttctgaaac     6900

aagccctcac aatagttggt actcttccat tcacatacat gctggagaaa tggcgttgga     6960

tggtttttaa gggggagata cctaaagatc agtggatgaa aaagtggtgg gagatgaagc     7020

gtgagatcgt aggggtcgtg gagccagtgc ctcatgatga gacttactgt gacccagcat     7080

cactcttcca cgttagcaat gactattcat ttatacgtta ttacactcgc actctttacc     7140

agtttcaatt tcaggaggct ctgtgtcagg ctgccaagca tgagggaccc cttcacaagt     7200

gtgatattag taacagtact gaggcaggcc aaaaactgtt caatatgttg aggcttggca     7260

aaagcgagcc atggactctc gccttggaaa atgttgtcgg ggctaaaaac atgaatgtac     7320

gccctctgct taactatttt gagccccttt ttacatggct caaggaccag aataagaact     7380

cctttgtcgg ctggtcaaca gactggtctc cctatgcaga ccctagtact cctcctactc     7440

cttctccatc aaccccacca actccatccc ctagctgctg tcacccaagg ctgtctctgc     7500

accgacctgc actcgaagac cttctgttgg gctctgaagc taacctgacc tgtactctta     7560

ctggcttgcg cgatgctagc ggcgtgactt tcacctggac acctagtagc ggtaaaagtg     7620

ctgtacaagg acctcctgaa cgcgacctgt gtggttgcta ctctgtgtct tctgtacttc     7680

ccggctgtgc cgagccctgg aatcacggga aaacctttac ctgcaccgcc gcttaccctg     7740

agtcaaaaac tcccctcact gccacattga gtaagtcagg gaatacattc aggccagagg     7800

ttcatttgtt gcctcctcca tctgaagaac ttgctttgaa cgagctggtc actctgacct     7860

gcttggctag gggtttctcc cccaaagatg tacttgtacg gtggttgcag ggcagccaag     7920

agttgccccg cgaaaagtat ttgacctggg cctcaagaca agaacccagc caggggacta     7980

ccacatttgc cgtgaccagt attctgcgtg tagccgctga agattggaag aaaggggata     8040

cattttcttg catggtaggg catgaggccc ttcccctcgc tttcactcag aagacaatag     8100

acagactcgc cggaaagcct actcacgtga atgttagcgt agtcatggct gaggttgacg     8160

gaacttgcta ctgagatatc cgatccaccg gatctagata actgatcata atcagccata     8220

ccacatttgt agaggtttta cttgctttaa aaaacctccc acacctcccc ctgaacctga     8280

aacataaaat gaatgcaatt gttgttgtta acttgtttat tgcagcttat aatggttaca     8340

aataaagcaa tagcatcaca aatttcacaa ataaagcatt tttttcactg cattctagtt     8400

gtggtttgtc caaactcatc aatgtatctt aggtttagtg aaccgtcaga tccgctagcg     8460

ttacataact tacggtaaat ggcccgcctg gctgaccgcc caacgacccc cgcccattga     8520

cgtcaataat gacgtatgtt cccatagtaa cgccaatagg gactttccat tgacgtcaat     8580

gggtggagta tttacggtaa actgcccact tggcagtaca tcaagtgtat catatgccaa     8640

gtacgccccc tattgacgtc aatgacggta aatggcccgc ctggcattat gcccagtaca     8700

tgaccttatg ggactttcct acttggcagt acatctacgt attagtcatc gctattacca     8760

tggtgatgcg gttttggcag tacatcaatg ggcgtggata gcggtttgac tcacggggat     8820

ttccaagtct ccaccccatt gacgtcaatg ggagtttgtt ttggcaccaa aatcaacggg     8880

actttccaaa atgtcgtaac aactccgccc cattgacgca aatgggcggt aggcgtgtac     8940

ggtgggaggt ctatataagc agagctggtt tagtgaaccg tcagatccgc tagagatctg     9000

gtaccgtcga cgcggccgct cgagcctaag cttatgaaga accatctgct tttctgggga     9060

gtacttgccg ttttcataaa agccgtacat gttaaagcac aagaggacga acgcattgtg     9120

ttggttgata ataaatgcaa atgtgctcgg ataacatctc ggatcattcg tagctcagag     9180

gaccccaatg aggatatagt agagcgaaac atcagaatta tagtacccct gaacaacaga     9240

gagaacataa gtgatcccac aagtccattg cggacacgct ttgtttacca tttgtctgat     9300

ctgtgtaaaa aatgtgatcc aacagaggtg gaactcgaca atcagatcgt caccgccacc     9360

cagtctaaca tctgcgatga agattcagct acagagacat gctacacata cgaccggaac     9420

aagtgctata ctgccgttgt gccactcgtt tacggtggag aaacaaagat ggttgaaact     9480

gcacttacac cagatgcctg ctatccagat tgagatatcc gatccaccgg atctagataa     9540

ctgatcataa tcagccatac cacatttgta gaggttttac ttgctttaaa aaacctccca     9600

cacctccccc tgaacctgaa acataaaatg aatgcaattg ttgttgttaa cttgtttatt     9660

gcagcttata atggttacaa ataaagcaat agcatcacaa atttcacaaa taaagcattt     9720

ttttcactgc attctagttg tggtttgtcc aaactcatca atgtatctta acgcggatct     9780

gggcgtggtt aagggtggga aagaatatat aaggtggggg tcttatgtag ttttgtatct     9840

gttttgcagc agccgccgcc gccatgagca ccaactcgtt tgatggaagc attgtgagct     9900

catatttgac aacgcgcatg cccccatggg ccggggtgcg tcagaatgtg atgggctcca     9960

gcattgatgg tcgccccgtc ctgcccgcaa actctactac cttgacctac gagaccgtgt    10020

ctggaacgcc gttggagact gcagcctccg ccgccgcttc agccgctgca gccaccgccc    10080

gcgggattgt gactgacttt gctttcctga gcccgcttgc aagcagtgca gcttcccgtt    10140

catccgcccg cgatgacaag ttgacggctc ttttggcaca attggattct ttgacccggg    10200

aacttaatgt cgtttctcag cagctgttgg atctgcgcca gcaggtttct gccctgaagg    10260

cttcctcccc tcccaatgcg gtttaaaaca taaataaaaa accagactct gtttggattt    10320

ggatcaagca agtgtcttgc tgtctttatt taggggtttt gcgcgcgcgg taggcccggg    10380

accagcggtc tcggtcgttg agggtcctgt gtattttttc caggacgtgg taaaggtgac    10440

tctggatgtt cagatacatg ggcataagcc cgtctctggg gtggaggtag caccactgca    10500

gagcttcatg ctgcggggtg gtgttgtaga tgatccagtc gtagcaggag cgctgggcgt    10560

ggtgcctaaa aatgtctttc agtagcaagc tgattgccag gggcaggccc ttggtgtaag    10620

tgtttacaaa gcggttaagc tgggatgggt gcatacgtgg ggatatgaga tgcatcttgg    10680

actgtatttt taggttggct atgttcccag ccatatccct ccggggattc atgttgtgca    10740

gaaccaccag cacagtgtat ccggtgcact tgggaaattt gtcatgtagc ttagaaggaa    10800

atgcgtggaa gaacttggag acgcccttgt gacctccaag attttccatg cattcgtcca    10860

taatgatggc aatgggccca cgggcggcgg cctgggcgaa gatatttctg ggatcactaa    10920

cgtcatagtt gtgttccagg atgagatcgt cataggccat ttttacaaag cgcgggcgga    10980

gggtgccaga ctgcggtata atggttccat ccggcccagg ggcgtagtta ccctcacaga    11040

tttgcatttc ccacgctttg agttcagatg gggggatcat gtctacctgc ggggcgatga    11100

agaaaacggt ttccggggta ggggagatca gctgggaaga aagcaggttc ctgagcagct    11160

gcgacttacc gcagccggtg ggcccgtaaa tcacacctat taccggctgc aactggtagt    11220

taagagagct gcagctgccg tcatccctga gcaggggggc cacttcgtta agcatgtccc    11280

tgactcgcat gttttccctg accaaatccg ccagaaggcg ctcgccgccc agcgatagca    11340

gttcttgcaa ggaagcaaag tttttcaacg gtttgagacc gtccgccgta ggcatgcttt    11400

tgagcgtttg accaagcagt tccaggcggt cccacagctc ggtcacctgc tctacggcat    11460

ctcgatccag catatctcct cgtttcgcgg gttggggcgg ctttcgctgt acggcagtag    11520

tcggtgctcg tccagacggg ccagggtcat gtctttccac gggcgcaggg tcctcgtcag    11580

cgtagtctgg gtcacggtga aggggtgcgc tccgggctgc gcgctggcca gggtgcgctt    11640

gaggctggtc ctgctggtgc tgaagcgctg ccggtcttcg ccctgcgcgt cggccaggta    11700

gcatttgacc atggtgtcat agtccagccc ctccgcggcg tggcccttgg cgcgcagctt    11760

gcccttggag gaggcgccgc acgaggggca gtgcagactt ttgagggcgt agagcttggg    11820

cgcgagaaat accgattccg gggagtaggc atccgcgccg caggccccgc agacggtctc    11880

gcattccacg agccaggtga gctctggccg ttcggggtca aaaaccaggt ttcccccatg    11940

ctttttgatg cgtttcttac ctctggtttc catgagccgg tgtccacgct cggtgacgaa    12000

aaggctgtcc gtgtccccgt atacagactt gagaggcctg tcctcgagcg gtgttccgcg    12060

gtcctcctcg tatagaaact cggaccactc tgagacaaag gctcgcgtcc aggccagcac    12120

gaaggaggct aagtgggagg ggtagcggtc gttgtccact agggggtcca ctcgctccag    12180

ggtgtgaaga cacatgtcgc cctcttcggc atcaaggaag gtgattggtt tgtaggtgta    12240

ggccacgtga ccgggtgttc ctgaaggggg gctataaaag ggggtggggg cgcgttcgtc    12300

ctcactctct tccgcatcgc tgtctgcgag ggccagctgt tggggtgagt actccctctg    12360

aaaagcgggc atgacttctg cgctaagatt gtcagtttcc aaaaacgagg aggatttgat    12420

attcacctgg cccgcggtga tgcctttgag ggtggccgca tccatctggt cagaaaagac    12480

aatctttttg ttgtcaagct tggtggcaaa cgacccgtag agggcgttgg acagcaactt    12540

ggcgatggag cgcagggttt ggtttttgtc gcgatcggcg cgctccttgg ccgcgatgtt    12600

tagctgcacg tattcgcgcg caacgcaccg ccattcggga aagacggtgg tgcgctcgtc    12660

gggcaccagg tgcacgcgcc aaccgcggtt gtgcagggtg acaaggtcaa cgctggtggc    12720

tacctctccg cgtaggcgct cgttggtcca gcagaggcgg ccgcccttgc gcgagcagaa    12780

tggcggtagg gggtctagct gcgtctcgtc cggggggtct gcgtccacgg taaagacccc    12840

gggcagcagg cgcgcgtcga agtagtctat cttgcatcct tgcaagtcta gcgcctgctg    12900

ccatgcgcgg gcggcaagcg cgcgctcgta tgggttgagt gggggacccc atggcatggg    12960

gtgggtgagc gcggaggcgt acatgccgca aatgtcgtaa acgtagaggg gctctctgag    13020

tattccaaga tatgtagggt agcatcttcc accgcggatg ctggcgcgca cgtaatcgta    13080

tagttcgtgc gagggagcga ggaggtcggg accgaggttg ctacgggcgg gctgctctgc    13140

tcggaagact atctgcctga agatggcatg tgagttggat gatatggttg gacgctggaa    13200

gacgttgaag ctggcgtctg tgagacctac cgcgtcacgc acgaaggagg cgtaggagtc    13260

gcgcagcttg ttgaccagct cggcggtgac ctgcacgtct agggcgcagt agtccagggt    13320

ttccttgatg atgtcatact tatcctgtcc cttttttttc cacagctcgc ggttgaggac    13380

aaactcttcg cggtctttcc agtactcttg gatcggaaac ccgtcggcct ccgaacggta    13440

agagcctagc atgtagaact ggttgacggc ctggtaggcg cagcatccct tttctacggg    13500

tagcgcgtat gcctgcgcgg ccttccggca tgaccagcat gaagggcacg agctgcttcc    13560

caaaggcccc catccaagta taggtctcta catcgtaggt gacaaagaga cgctcggtgc    13620

gaggatgcga gccgatcggg aagaactgga tctcccgcca ccaattggag gagtggctat    13680

tgatgtggtg aaagtagaag tccctgcgac gggccgaaca ctcgtgctgg cttttgtaaa    13740

aacgtgcgca gtactggcag cggtgcacgg gctgtacatc ctgcacgagg ttgacctgac    13800

gaccgcgcac aaggaagcag agtgggaatt tgagcccctc gcctggcggg tttggctggt    13860

ggtcttctac ttcggctgct tgtccttgac cgtctggctg ctcgagggga gttacggtgg    13920

atcggaccac cacgccgcgc gagcccaaag tccagatgtc cgcgcgcggc ggtcggagct    13980

tgatgacaac atcgcgcaga tgggagctgt ccatggtctg gagctcccgc ggcgtcaggt    14040

caggcgggag ctcctgcagg tttacctcgc atagacgggt cagggcgcgg gctagatcca    14100

ggtgatacct aatttccagg ggctggttgg tggcggcgtc gatggcttgc aagaggccgc    14160

atccccgcgg cgcgactacg gtaccgcgcg gcgggcggtg ggccgcgggg gtgtccttgg    14220

atgatgcatc taaaagcggt gacgcgggcg agcccccgga ggtagggggg gctccggacc    14280

cgccgggaga gggggcaggg gcacgtcggc gccgcgcgcg ggcaggagct ggtgctgcgc    14340

gcgtaggttg ctggcgaacg cgacgacgcg gcggttgatc tcctgaatct ggcgcctctg    14400

cgtgaagacg acgggcccgg tgagcttgaa cctgaaagag agttcgacag aatcaatttc    14460

ggtgtcgttg acggcggcct ggcgcaaaat ctcctgcacg tctcctgagt tgtcttgata    14520

ggcgatctcg gccatgaact gctcgatctc ttcctcctgg agatctccgc gtccggctcg    14580

ctccacggtg gcggcgaggt cgttggaaat gcgggccatg agctgcgaga aggcgttgag    14640

gcctccctcg ttccagacgc ggctgtagac cacgccccct tcggcatcgc gggcgcgcat    14700

gaccacctgc gcgagattga gctccacgtg ccgggcgaag acggcgtagt ttcgcaggcg    14760

ctgaaagagg tagttgaggg tggtggcggt gtgttctgcc acgaagaagt acataaccca    14820

gcgtcgcaac gtggattcgt tgataattgt tgtgtaggta ctccgccgcc gagggacctg    14880

agcgagtccg catcgaccgg atcggaaaac ctctcgagaa aggcgtctaa ccagtcacag    14940

tcgcaaggta ggctgagcac cgtggcgggc ggcagcgggc ggcggtcggg gttgtttctg    15000

gcggaggtgc tgctgatgat gtaattaaag taggcggtct tgagacggcg gatggtcgac    15060

agaagcacca tgtccttggg tccggcctgc tgaatgcgca ggcggtcggc catgccccag    15120

gcttcgtttt gacatcggcg caggtctttg tagtagtctt gcatgagcct ttctaccggc    15180

acttcttctt ctccttcctc ttgtcctgca tctcttgcat ctatcgctgc ggcggcggcg    15240

gagtttggcc gtaggtggcg ccctcttcct cccatgcgtg tgaccccgaa gcccctcatc    15300

ggctgaagca gggctaggtc ggcgacaacg cgctcggcta atatggcctg ctgcacctgc    15360

gtgagggtag actggaagtc atccatgtcc acaaagcggt ggtatgcgcc cgtgttgatg    15420

gtgtaagtgc agttggccat aacggaccag ttaacggtct ggtgacccgg ctgcgagagc    15480

tcggtgtacc tgagacgcga gtaagccctc gagtcaaata cgtagtcgtt gcaagtccgc    15540

accaggtact ggtatcccac caaaaagtgc ggcggcggct ggcggtagag gggccagcgt    15600

agggtggccg gggctccggg ggcgagatct tccaacataa ggcgatgata tccgtagatg    15660

tacctggaca tccaggtgat gccggcggcg gtggtggagg cgcgcggaaa gtcgcggacg    15720

cggttccaga tgttgcgcag cggcaaaaag tgctccatgg tcgggacgct ctggccggtc    15780

aggcgcgcgc aatcgttgac gctctagcgt gcaaaaggag agcctgtaag cgggcactct    15840

tccgtggtct ggtggataaa ttcgcaaggg tatcatggcg gacgaccggg gttcgagccc    15900

cgtatccggc cgtccgccgt gatccatgcg gttaccgccc gcgtgtcgaa cccaggtgtg    15960

cgacgtcaga caacggggga gtgctccttt tggcttcctt ccaggcgcgg cggctgctgc    16020

gctagctttt ttggccactg gccgcgcgca gcgtaagcgg ttaggctgga aagcgaaagc    16080

attaagtggc tcgctccctg tagccggagg gttattttcc aagggttgag tcgcgggacc    16140

cccggttcga gtctcggacc ggccggactg cggcgaacgg gggtttgcct ccccgtcatg    16200

caagaccccg cttgcaaatt cctccggaaa cagggacgag cccctttttt gcttttccca    16260

gatgcatccg gtgctgcggc agatgcgccc ccctcctcag cagcggcaag agcaagagca    16320

gcggcagaca tgcagggcac cctcccctcc tcctaccgcg tcaggagggg cgacatccgc    16380

ggttgacgcg gcagcagatg gtgattacga acccccgcgg cgccgggccc ggcactacct    16440

ggacttggag gagggcgagg gcctggcgcg gctaggagcg ccctctcctg agcggcaccc    16500

aagggtgcag ctgaagcgtg atacgcgtga ggcgtacgtg ccgcggcaga acctgtttcg    16560

cgaccgcgag ggagaggagc ccgaggagat gcgggatcga aagttccacg cagggcgcga    16620

gctgcggcat ggcctgaatc gcgagcggtt gctgcgcgag gaggactttg agcccgacgc    16680

gcgaaccggg attagtcccg cgcgcgcaca cgtggcggcc gccgacctgg taaccgcata    16740

cgagcagacg gtgaaccagg agattaactt tcaaaaaagc tttaacaacc acgtgcgtac    16800

gcttgtggcg cgcgaggagg tggctatagg actgatgcat ctgtgggact ttgtaagcgc    16860

gctggagcaa aacccaaata gcaagccgct catggcgcag ctgttcctta tagtgcagca    16920

cagcagggac aacgaggcat tcagggatgc gctgctaaac atagtagagc ccgagggccg    16980

ctggctgctc gatttgataa acatcctgca gagcatagtg gtgcaggagc gcagcttgag    17040

cctggctgac aaggtggccg ccatcaacta ttccatgctt agcctgggca agttttacgc    17100

ccgcaagata taccataccc cttacgttcc catagacaag gaggtaaaga tcgaggggtt    17160

ctacatgcgc atggcgctga aggtgcttac cttgagcgac gacctgggcg tttatcgcaa    17220

cgagcgcatc cacaaggccg tgagcgtgag ccggcggcgc gagctcagcg accgcgagct    17280

gatgcacagc ctgcaaaggg ccctggctgg cacgggcagc ggcgatagag aggccgagtc    17340

ctactttgac gcgggcgctg acctgcgctg ggccccaagc cgacgcgccc tggaggcagc    17400

tggggccgga cctgggctgg cggtggcacc cgcgcgcgct ggcaacgtcg gcggcgtgga    17460

ggaatatgac gaggacgatg agtacgagcc agaggacggc gagtactaag cggtgatgtt    17520

tctgatcaga tgatgcaaga cgcaacggac ccggcggtgc gggcggcgct gcagagccag    17580

ccgtccggcc ttaactccac ggacgactgg cgccaggtca tggaccgcat catgtcgctg    17640

actgcgcgca atcctgacgc gttccggcag cagccgcagg ccaaccggct ctccgcaatt    17700

ctggaagcgg tggtcccggc gcgcgcaaac cccacgcacg agaaggtgct ggcgatcgta    17760

aacgcgctgg ccgaaaacag ggccatccgg cccgacgagg ccggcctggt ctacgacgcg    17820

ctgcttcagc gcgtggctcg ttacaacagc ggcaacgtgc agaccaacct ggaccggctg    17880

gtgggggatg tgcgcgaggc cgtggcgcag cgtgagcgcg cgcagcagca gggcaacctg    17940

ggctccatgg ttgcactaaa cgccttcctg agtacacagc ccgccaacgt gccgcgggga    18000

caggaggact acaccaactt tgtgagcgca ctgcggctaa tggtgactga gacaccgcaa    18060

agtgaggtgt accagtctgg gccagactat tttttccaga ccagtagaca aggcctgcag    18120

accgtaaacc tgagccaggc tttcaaaaac ttgcaggggc tgtggggggt gcgggctccc    18180

acaggcgacc gcgcgaccgt gtctagcttg ctgacgccca actcgcgcct gttgctgctg    18240

ctaatagcgc ccttcacgga cagtggcagc gtgtcccggg acacatacct aggtcacttg    18300

ctgacactgt accgcgaggc cataggtcag gcgcatgtgg acgagcatac tttccaggag    18360

attacaagtg tcagccgcgc gctggggcag gaggacacgg gcagcctgga ggcaacccta    18420

aactacctgc tgaccaaccg gcggcagaag atcccctcgt tgcacagttt aaacagcgag    18480

gaggagcgca ttttgcgcta cgtgcagcag agcgtgagcc ttaacctgat gcgcgacggg    18540

gtaacgccca gcgtggcgct ggacatgacc gcgcgcaaca tggaaccggg catgtatgcc    18600

tcaaaccggc cgtttatcaa ccgcctaatg gactacttgc atcgcgcggc cgccgtgaac    18660

cccgagtatt tcaccaatgc catcttgaac ccgcactggc taccgccccc tggtttctac    18720

accgggggat tcgaggtgcc cgagggtaac gatggattcc tctgggacga catagacgac    18780

agcgtgtttt ccccgcaacc gcagaccctg ctagagttgc aacagcgcga gcaggcagag    18840

gcggcgctgc gaaaggaaag cttccgcagg ccaagcagct tgtccgatct aggcgctgcg    18900

gccccgcggt cagatgctag tagcccattt ccaagcttga tagggtctct taccagcact    18960

cgcaccaccc gcccgcgcct gctgggcgag gaggagtacc taaacaactc gctgctgcag    19020

ccgcagcgcg aaaaaaacct gcctccggca tttcccaaca acgggataga gagcctagtg    19080

gacaagatga gtagatggaa gacgtacgcg caggagcaca gggacgtgcc aggcccgcgc    19140

ccgcccaccc gtcgtcaaag gcacgaccgt cagcggggtc tggtgtggga ggacgatgac    19200

tcggcagacg acagcagcgt cctggatttg ggagggagtg gcaacccgtt tgcgcacctt    19260

cgccccaggc tggggagaat gttttaaaaa aaaaaaagca tgatgcaaaa taaaaaactc    19320

accaaggcca tggcaccgag cgttggtttt cttgtattcc ccttagtatg cggcgcgcgg    19380

cgatgtatga ggaaggtcct cctccctcct acgagagtgt ggtgagcgcg gcgccagtgg    19440

cggcggcgct gggttctccc ttcgatgctc ccctggaccc gccgtttgtg cctccgcggt    19500

acctgcggcc taccgggggg agaaacagca tccgttactc tgagttggca cccctattcg    19560

acaccacccg tgtgtacctg gtggacaaca agtcaacgga tgtggcatcc ctgaactacc    19620

agaacgacca cagcaacttt ctgaccacgg tcattcaaaa caatgactac agcccggggg    19680

aggcaagcac acagaccatc aatcttgacg accggtcgca ctggggcggc gacctgaaaa    19740

ccatcctgca taccaacatg ccaaatgtga acgagttcat gtttaccaat aagtttaagg    19800

cgcgggtgat ggtgtcgcgc ttgcctacta aggacaatca ggtggagctg aaatacgagt    19860

gggtggagtt cacgctgccc gagggcaact actccgagac catgaccata gaccttatga    19920

acaacgcgat cgtggagcac tacttgaaag tgggcagaca gaacggggtt ctggaaagcg    19980

acatcggggt aaagtttgac acccgcaact tcagactggg gtttgacccc gtcactggtc    20040

ttgtcatgcc tggggtatat acaaacgaag ccttccatcc agacatcatt ttgctgccag    20100

gatgcggggt ggacttcacc cacagccgcc tgagcaactt gttgggcatc cgcaagcggc    20160

aacccttcca ggagggcttt aggatcacct acgatgatct ggagggtggt aacattcccg    20220

cactgttgga tgtggacgcc taccaggcga gcttgaaaga tgacaccgaa cagggcgggg    20280

gtggcgcagg cggcagcaac agcagtggca gcggcgcgga agagaactcc aacgcggcag    20340

ccgcggcaat gcagccggtg gaggacatga acgatcatgc cattcgcggc gacacctttg    20400

ccacacgggc tgaggagaag cgcgctgagg ccgaagcagc ggccgaagct gccgcccccg    20460

ctgcgcaacc cgaggtcgag aagcctcaga agaaaccggt gatcaaaccc ctgacagagg    20520

acagcaagaa acgcagttac aacctaataa gcaatgacag caccttcacc cagtaccgca    20580

gctggtacct tgcatacaac tacggcgacc ctcagaccgg aatccgctca tggaccctgc    20640

tttgcactcc tgacgtaacc tgcggctcgg agcaggtcta ctggtcgttg ccagacatga    20700

tgcaagaccc cgtgaccttc cgctccacgc gccagatcag caactttccg gtggtgggcg    20760

ccgagctgtt gcccgtgcac tccaagagct tctacaacga ccaggccgtc tactcccaac    20820

tcatccgcca gtttacctct ctgacccacg tgttcaatcg ctttcccgag aaccagattt    20880

tggcgcgccc gccagccccc accatcacca ccgtcagtga aaacgttcct gctctcacag    20940

atcacgggac gctaccgctg cgcaacagca tcggaggagt ccagcgagtg accattactg    21000

acgccagacg ccgcacctgc ccctacgttt acaaggccct gggcatagtc tcgccgcgcg    21060

tcctatcgag ccgcactttt tgagcaagca tgtccatcct tatatcgccc agcaataaca    21120

caggctgggg cctgcgcttc ccaagcaaga tgtttggcgg ggccaagaag cgctccgacc    21180

aacacccagt gcgcgtgcgc gggcactacc gcgcgccctg gggcgcgcac aaacgcggcc    21240

gcactgggcg caccaccgtc gatgacgcca tcgacgcggt ggtggaggag gcgcgcaact    21300

acacgcccac gccgccacca gtgtccacag tggacgcggc cattcagacc gtggtgcgcg    21360

gagcccggcg ctatgctaaa atgaagagac ggcggaggcg cgtagcacgt cgccaccgcc    21420

gccgacccgg cactgccgcc caacgcgcgg cggcggccct gcttaaccgc gcacgtcgca    21480

ccggccgacg ggcggccatg cgggccgctc gaaggctggc cgcgggtatt gtcactgtgc    21540

cccccaggtc caggcgacga gcggccgccg cagcagccgc ggccattagt gctatgactc    21600

agggtcgcag gggcaacgtg tattgggtgc gcgactcggt tagcggcctg cgcgtgcccg    21660

tgcgcacccg ccccccgcgc aactagattg caagaaaaaa ctacttagac tcgtactgtt    21720

gtatgtatcc agcggcggcg gcgcgcaacg aagctatgtc caagcgcaaa atcaaagaag    21780

agatgctcca ggtcatcgcg ccggagatct atggcccccc gaagaaggaa gagcaggatt    21840

acaagccccg aaagctaaag cgggtcaaaa agaaaaagaa agatgatgat gatgaacttg    21900

acgacgaggt ggaactgctg cacgctaccg cgcccaggcg acgggtacag tggaaaggtc    21960

gacgcgtaaa acgtgttttg cgacccggca ccaccgtagt ctttacgccc ggtgagcgct    22020

ccacccgcac ctacaagcgc gtgtatgatg aggtgtacgg cgacgaggac ctgcttgagc    22080

aggccaacga gcgcctcggg gagtttgcct acggaaagcg gcataaggac atgctggcgt    22140

tgccgctgga cgagggcaac ccaacaccta gcctaaagcc cgtaacactg cagcaggtgc    22200

tgcccgcgct tgcaccgtcc gaagaaaagc gcggcctaaa gcgcgagtct ggtgacttgg    22260

cacccaccgt gcagctgatg gtacccaagc gccagcgact ggaagatgtc ttggaaaaaa    22320

tgaccgtgga acctgggctg gagcccgagg tccgcgtgcg gccaatcaag caggtggcgc    22380

cgggactggg cgtgcagacc gtggacgttc agatacccac taccagtagc accagtattg    22440

ccaccgccac agagggcatg gagacacaaa cgtccccggt tgcctcagcg gtggcggatg    22500

ccgcggtgca ggcggtcgct gcggccgcgt ccaagacctc tacggaggtg caaacggacc    22560

cgtggatgtt tcgcgtttca gccccccggc gcccgcgccg ttcgaggaag tacggcgccg    22620

ccagcgcgct actgcccgaa tatgccctac atccttccat tgcgcctacc cccggctatc    22680

gtggctacac ctaccgcccc agaagacgag caactacccg acgccgaacc accactggaa    22740

cccgccgccg ccgtcgccgt cgccagcccg tgctggcccc gatttccgtg cgcagggtgg    22800

ctcgcgaagg aggcaggacc ctggtgctgc caacagcgcg ctaccacccc agcatcgttt    22860

aaaagccggt ctttgtggtt cttgcagata tggccctcac ctgccgcctc cgtttcccgg    22920

tgccgggatt ccgaggaaga atgcaccgta ggaggggcat ggccggccac ggcctgacgg    22980

gcggcatgcg tcgtgcgcac caccggcggc ggcgcgcgtc gcaccgtcgc atgcgcggcg    23040

gtatcctgcc cctccttatt ccactgatcg ccgcggcgat tggcgccgtg cccggaattg    23100

catccgtggc cttgcaggcg cagagacact gattaaaaac aagttgcatg tggaaaaatc    23160

aaaataaaaa gtctggactc tcacgctcgc ttggtcctgt aactattttg tagaatggaa    23220

gacatcaact ttgcgtctct ggccccgcga cacggctcgc gcccgttcat gggaaactgg    23280

caagatatcg gcaccagcaa tatgagcggt ggcgccttca gctggggctc gctgtggagc    23340

ggcattaaaa atttcggttc caccgttaag aactatggca gcaaggcctg gaacagcagc    23400

acaggccaga tgctgaggga taagttgaaa gagcaaaatt tccaacaaaa ggtggtagat    23460

ggcctggcct ctggcattag cggggtggtg gacctggcca accaggcagt gcaaaataag    23520

attaacagta agcttgatcc ccgccctccc gtagaggagc ctccaccggc cgtggagaca    23580

gtgtctccag aggggcgtgg cgaaaagcgt ccgcgccccg acagggaaga aactctggtg    23640

acgcaaatag acgagcctcc ctcgtacgag gaggcactaa agcaaggcct gcccaccacc    23700

cgtcccatcg cgcccatggc taccggagtg ctgggccagc acacacccgt aacgctggac    23760

ctgcctcccc ccgccgacac ccagcagaaa cctgtgctgc caggcccgac cgccgttgtt    23820

gtaacccgtc ctagccgcgc gtccctgcgc cgcgccgcca gcggtccgcg atcgttgcgg    23880

cccgtagcca gtggcaactg gcaaagcaca ctgaacagca tcgtgggtct gggggtgcaa    23940

tccctgaagc gccgacgatg cttctgatag ctaacgtgtc gtatgtgtgt catgtatgcg    24000

tccatgtcgc cgccagagga gctgctgagc cgccgcgcgc ccgctttcca agatggctac    24060

cccttcgatg atgccgcagt ggtcttacat gcacatctcg ggccaggacg cctcggagta    24120

cctgagcccc gggctggtgc agtttgcccg cgccaccgag acgtacttca gcctgaataa    24180

caagtttaga aaccccacgg tggcgcctac gcacgacgtg accacagacc ggtcccagcg    24240

tttgacgctg cggttcatcc ctgtggaccg tgaggatact gcgtactcgt acaaggcgcg    24300

gttcacccta gctgtgggtg ataaccgtgt gctggacatg gcttccacgt actttgacat    24360

ccgcggcgtg ctggacaggg gccctacttt taagccctac tctggcactg cctacaacgc    24420

cctggctccc aagggtgccc caaatccttg cgaatgggat gaagctgcta ctgctcttga    24480

aataaaccta gaagaagagg acgatgacaa cgaagacgaa gtagacgagc aagctgagca    24540

gcaaaaaact cacgtatttg ggcaggcgcc ttattctggt ataaatatta caaaggaggg    24600

tattcaaata ggtgtcgaag gtcaaacacc taaatatgcc gataaaacat ttcaacctga    24660

acctcaaata ggagaatctc agtggtacga aacagaaatt aatcatgcag ctgggagagt    24720

cctaaaaaag actaccccaa tgaaaccatg ttacggttca tatgcaaaac ccacaaatga    24780

aaatggaggg caaggcattc ttgtaaagca acaaaatgga aagctagaaa gtcaagtgga    24840

aatgcaattt ttctcaacta ctgaggcagc cgcaggcaat ggtgataact tgactcctaa    24900

agtggtattg tacagtgaag atgtagatat agaaacccca gacactcata tttcttacat    24960

gcccactatt aaggaaggta actcacgaga actaatgggc caacaatcta tgcccaacag    25020

gcctaattac attgctttta gggacaattt tattggtcta atgtattaca acagcacggg    25080

taatatgggt gttctggcgg gccaagcatc gcagttgaat gctgttgtag atttgcaaga    25140

cagaaacaca gagctttcat accagctttt gcttgattcc attggtgata gaaccaggta    25200

cttttctatg tggaatcagg ctgttgacag ctatgatcca gatgttagaa ttattgaaaa    25260

tcatggaact gaagatgaac ttccaaatta ctgctttcca ctgggaggtg tgattaatac    25320

agagactctt accaaggtaa aacctaaaac aggtcaggaa aatggatggg aaaaagatgc    25380

tacagaattt tcagataaaa atgaaataag agttggaaat aattttgcca tggaaatcaa    25440

tctaaatgcc aacctgtgga gaaatttcct gtactccaac atagcgctgt atttgcccga    25500

caagctaaag tacagtcctt ccaacgtaaa aatttctgat aacccaaaca cctacgacta    25560

catgaacaag cgagtggtgg ctcccgggct agtggactgc tacattaacc ttggagcacg    25620

ctggtccctt gactatatgg acaacgtcaa cccatttaac caccaccgca atgctggcct    25680

gcgctaccgc tcaatgttgc tgggcaatgg tcgctatgtg cccttccaca tccaggtgcc    25740

tcagaagttc tttgccatta aaaacctcct tctcctgccg ggctcataca cctacgagtg    25800

gaacttcagg aaggatgtta acatggttct gcagagctcc ctaggaaatg acctaagggt    25860

tgacggagcc agcattaagt ttgatagcat ttgcctttac gccaccttct tccccatggc    25920

ccacaacacc gcctccacgc ttgaggccat gcttagaaac gacaccaacg accagtcctt    25980

taacgactat ctctccgccg ccaacatgct ctaccctata cccgccaacg ctaccaacgt    26040

gcccatatcc atcccctccc gcaactgggc ggctttccgc ggctgggcct tcacgcgcct    26100

taagactaag gaaaccccat cactgggctc gggctacgac ccttattaca cctactctgg    26160

ctctataccc tacctagatg gaacctttta cctcaaccac acctttaaga aggtggccat    26220

tacctttgac tcttctgtca gctggcctgg caatgaccgc ctgcttaccc ccaacgagtt    26280

tgaaattaag cgctcagttg acggggaggg ttacaacgtt gcccagtgta acatgaccaa    26340

agactggttc ctggtacaaa tgctagctaa ctataacatt ggctaccagg gcttctatat    26400

cccagagagc tacaaggacc gcatgtactc cttctttaga aacttccagc ccatgagccg    26460

tcaggtggtg gatgatacta aatacaagga ctaccaacag gtgggcatcc tacaccaaca    26520

caacaactct ggatttgttg gctaccttgc ccccaccatg cgcgaaggac aggcctaccc    26580

tgctaacttc ccctatccgc ttataggcaa gaccgcagtt gacagcatta cccagaaaaa    26640

gtttctttgc gatcgcaccc tttggcgcat cccattctcc agtaacttta tgtccatggg    26700

cgcactcaca gacctgggcc aaaaccttct ctacgccaac tccgcccacg cgctagacat    26760

gacttttgag gtggatccca tggacgagcc cacccttctt tatgttttgt ttgaagtctt    26820

tgacgtggtc cgtgtgcacc agccgcaccg cggcgtcatc gaaaccgtgt acctgcgcac    26880

gcccttctcg gccggcaacg ccacaacata aagaagcaag caacatcaac aacagctgcc    26940

gccatgggct ccagtgagca ggaactgaaa gccattgtca aagatcttgg ttgtgggcca    27000

tattttttgg gcacctatga caagcgcttt ccaggctttg tttctccaca caagctcgcc    27060

tgcgccatag tcaatacggc cggtcgcgag actgggggcg tacactggat ggcctttgcc    27120

tggaacccgc actcaaaaac atgctacctc tttgagccct ttggcttttc tgaccagcga    27180

ctcaagcagg tttaccagtt tgagtacgag tcactcctgc gccgtagcgc cattgcttct    27240

tcccccgacc gctgtataac gctggaaaag tccacccaaa gcgtacaggg gcccaactcg    27300

gccgcctgtg gactattctg ctgcatgttt ctccacgcct ttgccaactg gccccaaact    27360

cccatggatc acaaccccac catgaacctt attaccgggg tacccaactc catgctcaac    27420

agtccccagg tacagcccac cctgcgtcgc aaccaggaac agctctacag cttcctggag    27480

cgccactcgc cctacttccg cagccacagt gcgcagatta ggagcgccac ttctttttgt    27540

cacttgaaaa acatgtaaaa ataatgtact agagacactt tcaataaagg caaatgcttt    27600

tatttgtaca ctctcgggtg attatttacc cccacccttg ccgtctgcgc cgtttaaaaa    27660

tcaaaggggt tctgccgcgc atcgctatgc gccactggca gggacacgtt gcgatactgg    27720

tgtttagtgc tccacttaaa ctcaggcaca accatccgcg gcagctcggt gaagttttca    27780

ctccacaggc tgcgcaccat caccaacgcg tttagcaggt cgggcgccga tatcttgaag    27840

tcgcagttgg ggcctccgcc ctgcgcgcgc gagttgcgat acacagggtt gcagcactgg    27900

aacactatca gcgccgggtg gtgcacgctg gccagcacgc tcttgtcgga gatcagatcc    27960

gcgtccaggt cctccgcgtt gctcagggcg aacggagtca actttggtag ctgccttccc    28020

aaaaagggcg cgtgcccagg ctttgagttg cactcgcacc gtagtggcat caaaaggtga    28080

ccgtgcccgg tctgggcgtt aggatacagc gcctgcataa aagccttgat ctgcttaaaa    28140

gccacctgag cctttgcgcc ttcagagaag aacatgccgc aagacttgcc ggaaaactga    28200

ttggccggac aggccgcgtc gtgcacgcag caccttgcgt cggtgttgga gatctgcacc    28260

acatttcggc cccaccggtt cttcacgatc ttggccttgc tagactgctc cttcagcgcg    28320

cgctgcccgt tttcgctcgt cacatccatt tcaatcacgt gctccttatt tatcataatg    28380

cttccgtgta gacacttaag ctcgccttcg atctcagcgc agcggtgcag ccacaacgcg    28440

cagcccgtgg gctcgtgatg cttgtaggtc acctctgcaa acgactgcag gtacgcctgc    28500

aggaatcgcc ccatcatcgt cacaaaggtc ttgttgctgg tgaaggtcag ctgcaacccg    28560

cggtgctcct cgttcagcca ggtcttgcat acggccgcca gagcttccac ttggtcaggc    28620

agtagtttga agttcgcctt tagatcgtta tccacgtggt acttgtccat cagcgcgcgc    28680

gcagcctcca tgcccttctc ccacgcagac acgatcggca cactcagcgg gttcatcacc    28740

gtaatttcac tttccgcttc gctgggctct tcctcttcct cttgcgtccg cataccacgc    28800

gccactgggt cgtcttcatt cagccgccgc actgtgcgct tacctccttt gccatgcttg    28860

attagcaccg gtgggttgct gaaacccacc atttgtagcg ccacatcttc tctttcttcc    28920

tcgctgtcca cgattacctc tggtgatggc gggcgctcgg gcttgggaga agggcgcttc    28980

tttttcttct tgggcgcaat ggccaaatcc gccgccgagg tcgatggccg cgggctgggt    29040

gtgcgcggca ccagcgcgtc ttgtgatgag tcttcctcgt cctcggactc gatacgccgc    29100

ctcatccgct tttttggggg cgcccgggga ggcggcggcg acggggacgg ggacgacacg    29160

tcctccatgg ttgggggacg tcgcgccgca ccgcgtccgc gctcgggggt ggtttcgcgc    29220

tgctcctctt cccgactggc catttccttc tcctataggc agaaaaagat catggagtca    29280

gtcgagaaga aggacagcct aaccgccccc tctgagttcg ccaccaccgc ctccaccgat    29340

gccgccaacg cgcctaccac cttccccgtc gaggcacccc cgcttgagga ggaggaagtg    29400

attatcgagc aggacccagg ttttgtaagc gaagacgacg aggaccgctc agtaccaaca    29460

gaggataaaa agcaagacca ggacaacgca gaggcaaacg aggaacaagt cgggcggggg    29520

gacgaaaggc atggcgacta cctagatgtg ggagacgacg tgctgttgaa gcatctgcag    29580

cgccagtgcg ccattatctg cgacgcgttg caagagcgca gcgatgtgcc cctcgccata    29640

gcggatgtca gccttgccta cgaacgccac ctattctcac cgcgcgtacc ccccaaacgc    29700

caagaaaacg gcacatgcga gcccaacccg cgcctcaact tctaccccgt atttgccgtg    29760

ccagaggtgc ttgccaccta tcacatcttt ttccaaaact gcaagatacc cctatcctgc    29820

cgtgccaacc gcagccgagc ggacaagcag ctggccttgc ggcagggcgc tgtcatacct    29880

gatatcgcct cgctcaacga agtgccaaaa atctttgagg gtcttggacg cgacgagaag    29940

cgcgcggcaa acgctctgca acaggaaaac agcgaaaatg aaagtcactc tggagtgttg    30000

gtggaactcg agggtgacaa cgcgcgccta gccgtactaa aacgcagcat cgaggtcacc    30060

cactttgcct acccggcact taacctaccc cccaaggtca tgagcacagt catgagtgag    30120

ctgatcgtgc gccgtgcgca gcccctggag agggatgcaa atttgcaaga acaaacagag    30180

gagggcctac ccgcagttgg cgacgagcag ctagcgcgct ggcttcaaac gcgcgagcct    30240

gccgacttgg aggagcgacg caaactaatg atggccgcag tgctcgttac cgtggagctt    30300

gagtgcatgc agcggttctt tgctgacccg gagatgcagc gcaagctaga ggaaacattg    30360

cactacacct ttcgacaggg ctacgtacgc caggcctgca agatctccaa cgtggagctc    30420

tgcaacctgg tctcctacct tggaattttg cacgaaaacc gccttgggca aaacgtgctt    30480

cattccacgc tcaagggcga ggcgcgccgc gactacgtcc gcgactgcgt ttacttattt    30540

ctatgctaca cctggcagac ggccatgggc gtttggcagc agtgcttgga ggagtgcaac    30600

ctcaaggagc tgcagaaact gctaaagcaa aacttgaagg acctatggac ggccttcaac    30660

gagcgctccg tggccgcgca cctggcggac atcattttcc ccgaacgcct gcttaaaacc    30720

ctgcaacagg gtctgccaga cttcaccagt caaagcatgt tgcagaactt taggaacttt    30780

atcctagagc gctcaggaat cttgcccgcc acctgctgtg cacttcctag cgactttgtg    30840

cccattaagt accgcgaatg ccctccgccg ctttggggcc actgctacct tctgcagcta    30900

gccaactacc ttgcctacca ctctgacata atggaagacg tgagcggtga cggtctactg    30960

gagtgtcact gtcgctgcaa cctatgcacc ccgcaccgct ccctggtttg caattcgcag    31020

ctgcttaacg aaagtcaaat tatcggtacc tttgagctgc agggtccctc gcctgacgaa    31080

aagtccgcgg ctccggggtt gaaactcact ccggggctgt ggacgtcggc ttaccttcgc    31140

aaatttgtac ctgaggacta ccacgcccac gagattaggt tctacgaaga ccaatcccgc    31200

ccgcctaatg cggagcttac cgcctgcgtc attacccagg gccacattct tggccaattg    31260

caagccatca acaaagcccg ccaagagttt ctgctacgaa agggacgggg ggtttacttg    31320

gacccccagt ccggcgagga gctcaaccca atccccccgc cgccgcagcc ctatcagcag    31380

cagccgcggg cccttgcttc ccaggatggc acccaaaaag aagctgcagc tgccgccgcc    31440

acccacggac gaggaggaat actgggacag tcaggcagag gaggttttgg acgaggagga    31500

ggaggacatg atggaagact gggagagcct agacgaggaa gcttccgagg tcgaagaggt    31560

gtcagacgaa acaccgtcac cctcggtcgc attcccctcg ccggcgcccc agaaatcggc    31620

aaccggttcc agcatggcta caacctccgc tcctcaggcg ccgccggcac tgcccgttcg    31680

ccgacccaac cgtagatggg acaccactgg aaccagggcc ggtaagtcca agcagccgcc    31740

gccgttagcc caagagcaac aacagcgcca aggctaccgc tcatggcgcg ggcacaagaa    31800

cgccatagtt gcttgcttgc aagactgtgg gggcaacatc tccttcgccc gccgctttct    31860

tctctaccat cacggcgtgg ccttcccccg taacatcctg cattactacc gtcatctcta    31920

cagcccatac tgcaccggcg gcagcggcag caacagcagc ggccacacag aagcaaaggc    31980

gaccggatag caagactctg acaaagccca agaaatccac agcggcggca gcagcaggag    32040

gaggagcgct gcgtctggcg cccaacgaac ccgtatcgac ccgcgagctt agaaacagga    32100

tttttcccac tctgtatgct atatttcaac agagcagggg ccaagaacaa gagctgaaaa    32160

taaaaaacag gtctctgcga tccctcaccc gcagctgcct gtatcacaaa agcgaagatc    32220

agcttcggcg cacgctggaa gacgcggagg ctctcttcag taaatactgc gcgctgactc    32280

ttaaggacta gtttcgcgcc ctttctcaaa tttaagcgcg aaaactacgt catctccagc    32340

ggccacaccc ggcgccagca cctgttgtca gcgccattat gagcaaggaa attcccacgc    32400

cctacatgtg gagttaccag ccacaaatgg gacttgcggc tggagctgcc caagactact    32460

caacccgaat aaactacatg agcgcgggac cccacatgat atcccgggtc aacggaatac    32520

gcgcccaccg aaaccgaatt ctcctggaac aggcggctat taccaccaca cctcgtaata    32580

accttaatcc ccgtagttgg cccgctgccc tggtgtacca ggaaagtccc gctcccacca    32640

ctgtggtact tcccagagac gcccaggccg aagttcagat gactaactca ggggcgcagc    32700

ttgcgggcgg ctttcgtcac agggtgcggt cgcccgggca gggtataact cacctgacaa    32760

tcagagggcg aggtattcag ctcaacgacg agtcggtgag ctcctcgctt ggtctccgtc    32820

cggacgggac atttcagatc ggcggcgccg gccgctcttc attcacgcct cgtcaggcaa    32880

tcctaactct gcagacctcg tcctctgagc cgcgctctgg aggcattgga actctgcaat    32940

ttattgagga gtttgtgcca tcggtctact ttaacccctt ctcgggacct cccggccact    33000

atccggatca atttattcct aactttgacg cggtaaagga ctcggcggac ggctacgact    33060

gaatgttaag tggagaggca gagcaactgc gcctgaaaca cctggtccac tgtcgccgcc    33120

acaagtgctt tgcccgcgac tccggtgagt tttgctactt tgaattgccc gaggatcata    33180

tcgagggccc ggcgcacggc gtccggctta ccgcccaggg agagcttgcc cgtagcctga    33240

ttcgggagtt tacccagcgc cccctgctag ttgagcggga caggggaccc tgtgttctca    33300

ctgtgatttg caactgtcct aaccctggat tacatcaaga tcctctagtt aatgtcaggt    33360

cgcctaagtc gattaactag agtacccggg gatcttattc cctttaacta ataaaaaaaa    33420

ataataaagc atcacttact taaaatcagt tagcaaattt ctgtccagtt tattcagcag    33480

cacctccttg ccctcctccc agctctggta ttgcagcttc ctcctggctg caaactttct    33540

ccacaatcta aatggaatgt cagtttcctc ctgttcctgt ccatccgcac ccactatctt    33600

catgttgttg cagatgaagc gcgcaagacc gtctgaagat accttcaacc ccgtgtatcc    33660

atatgacacg gaaaccggtc ctccaactgt gccttttctt actcctccct ttgtatcccc    33720

caatgggttt caagagagtc cccctggggt actctctttg cgcctatccg aacctctagt    33780

tacctccaat ggcatgcttg cgctcaaaat gggcaacggc ctctctctgg acgaggccgg    33840

caaccttacc tcccaaaatg taaccactgt gagcccacct ctcaaaaaaa ccaagtcaaa    33900

cataaacctg gaaatatctg cacccctcac agttacctca gaagccctaa ctgtggctgc    33960

cgccgcacct ctaatggtcg cgggcaacac actcaccatg caatcacagg ccccgctaac    34020

cgtgcacgac tccaaactta gcattgccac ccaaggaccc ctcacagtgt cagaaggaaa    34080

gctagccctg caaacatcag gccccctcac caccaccgat agcagtaccc ttactatcac    34140

tgcctcaccc cctctaacta ctgccactgg tagcttgggc attgacttga aagagcccat    34200

ttatacacaa aatggaaaac taggactaaa gtacggggct cctttgcatg taacagacga    34260

cctaaacact ttgaccgtag caactggtcc aggtgtgact attaataata cttccttgca    34320

aactaaagtt actggagcct tgggttttga ttcacaaggc aatatgcaac ttaatgtagc    34380

aggaggacta aggattgatt ctcaaaacag acgccttata cttgatgtta gttatccgtt    34440

tgatgctcaa aaccaactaa atctaagact aggacagggc cctcttttta taaactcagc    34500

ccacaacttg gatattaact acaacaaagg cctttacttg tttacagctt caaacaattc    34560

caaaaagctt gaggttaacc taagcactgc caaggggttg atgtttgacg ctacagccat    34620

agccattaat gcaggagatg ggcttgaatt tggttcacct aatgcaccaa acacaaatcc    34680

cctcaaaaca aaaattggcc atggcctaga atttgattca aacaaggcta tggttcctaa    34740

actaggaact ggccttagtt ttgacagcac aggtgccatt acagtaggaa acaaaaataa    34800

tgataagcta actttgtgga ccacaccagc tccatctcct aactgtagac taaatgcaga    34860

gaaagatgct aaactcactt tggtcttaac aaaatgtggc agtcaaatac ttgctacagt    34920

ttcagttttg gctgttaaag gcagtttggc tccaatatct ggaacagttc aaagtgctca    34980

tcttattata agatttgacg aaaatggagt gctactaaac aattccttcc tggacccaga    35040

atattggaac tttagaaatg gagatcttac tgaaggcaca gcctatacaa acgctgttgg    35100

atttatgcct aacctatcag cttatccaaa atctcacggt aaaactgcca aaagtaacat    35160

tgtcagtcaa gtttacttaa acggagacaa aactaaacct gtaacactaa ccattacact    35220

aaacggtaca caggaaacag gagacacaac tccaagtgca tactctatgt cattttcatg    35280

ggactggtct ggccacaact acattaatga aatatttgcc acatcctctt acactttttc    35340

atacattgcc caagaataaa gaatcgtttg tgttatgttt caacgtgttt atttttcaat    35400

tgcagaaaat ttcaagtcat ttttcattca gtagtatagc cccaccacca catagcttat    35460

acagatcacc gtaccttaat caaactcaca gaaccctagt attcaacctg ccacctccct    35520

cccaacacac agagtacaca gtcctttctc cccggctggc cttaaaaagc atcatatcat    35580

gggtaacaga catattctta ggtgttatat tccacacggt ttcctgtcga gccaaacgct    35640

catcagtgat attaataaac tccccgggca gctcacttaa gttcatgtcg ctgtccagct    35700

gctgagccac aggctgctgt ccaacttgcg gttgcttaac gggcggcgaa ggagaagtcc    35760

acgcctacat gggggtagag tcataatcgt gcatcaggat agggcggtgg tgctgcagca    35820

gcgcgcgaat aaactgctgc cgccgccgct ccgtcctgca ggaatacaac atggcagtgg    35880

tctcctcagc gatgattcgc accgcccgca gcataaggcg ccttgtcctc cgggcacagc    35940

agcgcaccct gatctcactt aaatcagcac agtaactgca gcacagcacc acaatattgt    36000

tcaaaatccc acagtgcaag gcgctgtatc caaagctcat ggcggggacc acagaaccca    36060

cgtggccatc ataccacaag cgcaggtaga ttaagtggcg acccctcata aacacgctgg    36120

acataaacat tacctctttt ggcatgttgt aattcaccac ctcccggtac catataaacc    36180

tctgattaaa catggcgcca tccaccacca tcctaaacca gctggccaaa acctgcccgc    36240

cggctataca ctgcagggaa ccgggactgg aacaatgaca gtggagagcc caggactcgt    36300

aaccatggat catcatgctc gtcatgatat caatgttggc acaacacagg cacacgtgca    36360

tacacttcct caggattaca agctcctccc gcgttagaac catatcccag ggaacaaccc    36420

attcctgaat cagcgtaaat cccacactgc agggaagacc tcgcacgtaa ctcacgttgt    36480

gcattgtcaa agtgttacat tcgggcagca gcggatgatc ctccagtatg gtagcgcggg    36540

tttctgtctc aaaaggaggt agacgatccc tactgtacgg agtgcgccga gacaaccgag    36600

atcgtgttgg tcgtagtgtc atgccaaatg gaacgccgga cgtagtcata tttcctgaag    36660

caaaaccagg tgcgggcgtg acaaacagat ctgcgtctcc ggtctcgccg cttagatcgc    36720

tctgtgtagt agttgtagta tatccactct ctcaaagcat ccaggcgccc cctggcttcg    36780

ggttctatgt aaactccttc atgcgccgct gccctgataa catccaccac cgcagaataa    36840

gccacaccca gccaacctac acattcgttc tgcgagtcac acacgggagg agcgggaaga    36900

gctggaagaa ccatgttttt ttttttattc caaaagatta tccaaaacct caaaatgaag    36960

atctattaag tgaacgcgct cccctccggt ggcgtggtca aactctacag ccaaagaaca    37020

gataatggca tttgtaagat gttgcacaat ggcttccaaa aggcaaacgg ccctcacgtc    37080

caagtggacg taaaggctaa acccttcagg gtgaatctcc tctataaaca ttccagcacc    37140

ttcaaccatg cccaaataat tctcatctcg ccaccttctc aatatatctc taagcaaatc    37200

ccgaatatta agtccggcca ttgtaaaaat ctgctccaga gcgccctcca ccttcagcct    37260

caagcagcga atcatgattg caaaaattca ggttcctcac agacctgtat aagattcaaa    37320

agcggaacat taacaaaaat accgcgatcc cgtaggtccc ttcgcagggc cagctgaaca    37380

taatcgtgca ggtctgcacg gaccagcgcg gccacttccc cgccaggaac catgacaaaa    37440

gaacccacac tgattatgac acgcatactc ggagctatgc taaccagcgt agccccgatg    37500

taagcttgtt gcatgggcgg cgatataaaa tgcaaggtgc tgctcaaaaa atcaggcaaa    37560

gcctcgcgca aaaaagaaag cacatcgtag tcatgctcat gcagataaag gcaggtaagc    37620

tccggaacca ccacagaaaa agacaccatt tttctctcaa acatgtctgc gggtttctgc    37680

ataaacacaa aataaaataa caaaaaaaca tttaaacatt agaagcctgt cttacaacag    37740

gaaaaacaac ccttataagc ataagacgga ctacggccat gccggcgtga ccgtaaaaaa    37800

actggtcacc gtgattaaaa agcaccaccg acagctcctc ggtcatgtcc ggagtcataa    37860

tgtaagactc ggtaaacaca tcaggttgat tcacatcggt cagtgctaaa aagcgaccga    37920

aatagcccgg gggaatacat acccgcaggc gtagagacaa cattacagcc cccataggag    37980

gtataacaaa attaatagga gagaaaaaca cataaacacc tgaaaaaccc tcctgcctag    38040

gcaaaatagc accctcccgc tccagaacaa catacagcgc ttccacagcg gcagccataa    38100

cagtcagcct taccagtaaa aaagaaaacc tattaaaaaa acaccactcg acacggcacc    38160

agctcaatca gtcacagtgt aaaaaagggc caagtgcaga gcgagtatat ataggactaa    38220

aaaatgacgt aacggttaaa gtccacaaaa aacacccaga aaaccgcacg cgaacctacg    38280

cccagaaacg aaagccaaaa aacccacaac ttcctcaaat cgtcacttcc gttttcccac    38340

gttacgtcac ttcccatttt aagaaaacta caattcccaa cacatacaag ttactccgcc    38400

ctaaaaccta cgtcacccgc cccgttccca cgccccgcgc cacgtcacaa actccacccc    38460

ctcattatca tattggcttc aatccaaaat aaggta                              38496


<210>  223
<211>  9701
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  vector for IgG1 against T27Y H34A R273L ACE2 mutant


<220>
<221>  misc_feature
<222>  (2929)..(2930)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (2934)..(2934)
<223>  n is a, c, g, or t

<400>  223
ggcgtaatct gctgcttgca aacaaaaaaa ccaccgctac cagcggtggt ttgtttgccg       60

gatcaagagc taccaactct ttttccgaag gtaactggct tcagcagagc gcagatacca      120

aatactgtcc ttctagtgta gccgtagtta ggccaccact tcaagaactc tgtagcaccg      180

cctacatacc tcgctctgct gaagccagtt accagtggct gctgccagtg gcgataagtc      240

gtgtcttacc gggttggact caagagatag ttaccggata aggcgcagcg gtcgggctga      300

acggggggtt cgtgcacaca gcccagcttg gagcgaacga cctacaccga actgagatac      360

ctacagcgtg agctatgaga aagcgccacg cttcccgaag ggagaaaggc ggacaggtat      420

ccggtaagcg gcagggtcgg aacaggagag cgcacgaggg agcttccagg gggaaacgcc      480

tggtatcttt atagtcctgt cgggtttcgc cacctctgac ttgagcgtcg atttttgtga      540

tgctcgtcag gggggcggag cctatggaaa aacgccagca acgcaagcta gagtttaaac      600

ttgacagatg agacaataac cctgataaat gcttcaataa tattgaaaaa ggaaaagtat      660

gagtattcaa catttccgtg tcgcccttat tccctttttt gcggcatttt gccttcctgt      720

ttttgctcac ccagaaacgc tggtgaaagt aaaagatgca gaagatcact tgggtgcgcg      780

agtgggttac atcgaactgg atctcaacag cggtaagatc cttgagagtt ttcgccccga      840

agaacgtttc ccaatgatga gcacttttaa agttctgcta tgtggcgcgg tattatcccg      900

tattgatgcc gggcaagagc aactcggtcg ccgcatacac tattctcaga atgacttggt      960

tgaatactca ccagtcacag aaaagcatct tacggatggc atgacagtaa gagaattatg     1020

cagtgctgcc ataaccatga gtgataacac tgcggccaac ttacttctga caactatcgg     1080

aggaccgaag gagctaaccg cttttttgca caacatgggg gatcatgtaa ctcgccttga     1140

tcgttgggaa ccggagctga atgaagccat accaaacgac gagcgtgaca ccacgatgcc     1200

tgtagcaatg gcaacaacgt tgcgaaaact attaactggc gaactactta ctctagcttc     1260

ccggcaacaa ctaatagact ggatggaggc ggataaagtt gcaggaccac ttctgcgctc     1320

ggcacttccg gctggctggt ttattgctga taaatcagga gccggtgagc gtgggtcacg     1380

cggtatcatt gcagcactgg ggccggatgg taagccctcc cgtatcgtag ttatctacac     1440

tacggggagt caggcaacta tggatgaacg aaatagacag atcgctgaga taggtgcctc     1500

actgattaag cattggtaag gataaatttc tggtaaggag gacacgtatg gaagtgggca     1560

agttggggaa gccgtatccg ttgctgaatc tggcatatgt gggagtataa gacgcgcagc     1620

gtcgcatcag gcattttttt ctgcgccaat gcaaaaaggc catccgtcag gatggccttt     1680

cggcataact agggccgccg atatttgaaa atatggcata ttgaaaatgt cgccgatgtg     1740

agtttctgtg taactgatat cgccattttt ccaaaagtga tttttgggca tacgcgatat     1800

ctggcgatag cgcttatatc gtttacgggg gatggcgata gacgactttg gtgacttggg     1860

cgattctgtg tgtcgcaaat atcgcagttt cgatataggt gacagacgat atgaggctat     1920

atcgccgata gaggcgacat caagctggca catggccaat gcatatcgat ctatacattg     1980

aatcaatatt ggccattagc catattattc attggttata tagcataaat caatattggc     2040

tattggccat tgcatacgtt gtatccatat cataatatgt acatttatat tggctcatgt     2100

ccaacattac cgccatgttg acattgatta ttgactagtt attaatagta atcaattacg     2160

gggtcattag ttcatagccc atatatggag ttccgcgtta cataacttac ggtaaatggc     2220

ccgcctggct gaccgcccaa cgacccccgc ccattgacgt caataatgac gtatgttccc     2280

atagtaacgc caatagggac tttccattga cgtcaatggg tggagtattt acggtaaact     2340

gcccacttgg cagtacatca agtgtatcat atgccaagta cgccccctat tgacgtcaat     2400

gacggtaaat ggcccgcctg gcattatgcc cagtacatga ccttatggga ctttcctact     2460

tggcagtaca tctacgtatt agtcatcgct attaccatgg tgatgcggtt ttggcagtac     2520

atcaatgggc gtggatagcg gtttgactca cggggatttc caagtctcca ccccattgac     2580

gtcaatggga gtttgttttg gcaccaaaat caacgggact ttccaaaatg tcgtaacaac     2640

tccgccccat tgacgcaaat gggcggtagg cgtgtacggt gggaggtcta tataagcaga     2700

gctcgtttag tgaaccgtca gatcgcctgg agacgccatc cacgctgttt tgacctccat     2760

agaagacacc gggaccgatc cagcctccgc ggccgggaac ggtgcattgg aacgcggatt     2820

ccccgtgcca agagtgacgt aagtaccgcc tatagagtct ataggcccac ccccttggct     2880

tcttatgcat gctatactgt ttttggcttg gggtctatac accccccgnn ttcntcatgt     2940

tataggtgat ggtatagctt agcctatagg tgtgggttat tgaccattat tgaccactcc     3000

ccctattggt gacgatactt tccattacta atccataaca tggctctttg ccacaactct     3060

ctttattggc tatatgccaa tacactgtcc ttcagagact gacacggact ctgtattttt     3120

acaggatggg gtctcattta ttatttacaa attcacatat acaacaccac cgtccccagt     3180

gcccgcagtt tttattaaac ataacgtggg atctccacgc gaatctcggg tacgtgttcc     3240

ggacatgggc tcttctccgg tagcggcgga gcttctacat ccgagccctg ctcccatgcc     3300

tccagcgact catggtcgct cggcagctcc ttgctcctaa cagtggaggc cagacttagg     3360

cacagcacga tgcccaccac caccagtgtg ccgcacaagg ccgtggcggt agggtatgtg     3420

tctgaaaatg agctcgggga gcgggcttgc accgctgacg catttggaag acttaaggca     3480

gcggcagaag aagatgcagg cagctgagtt gttgtgttct gataagagtc agaggtaact     3540

cccgttgcgg tgctgttaac ggtggagggc agtgtagtct gagcagtact cgttgctgcc     3600

gcgcgcgcca ccagacataa tagctgacag actaacagac tgttcctttc catgggtctt     3660

ttctgcagtc accgtccttg acacgaagct gctagcgcca ccatgagcag cagtagttgg     3720

cttctcttga gtttggtggc agtgacagca gcccagagta ctatcgagga gcaggctaaa     3780

tactttctgg ataagtttaa cgccgaggcc gaagacttgt tctatcaatc ttctctcgct     3840

tcatggaatt acaatactaa catcactgag gagaacgtcc agaatatgaa caatgctggc     3900

gacaaatgga gcgccttctt gaaggagcag tctacccttg cacaaatgta tccactgcag     3960

gagatacaga accttacagt aaagttgcag ctccaggctc tccagcagaa cggatctagc     4020

gtgctttcag aggataaaag caaaaggctg aacaccatac ttaataccat gtccacaatt     4080

tactctactg gtaaagtatg taaccccgac aaccctcaag aatgcctcct tcttgagcca     4140

ggcctcaatg agatcatggc taatagtctg gactataatg aaagactgtg ggcatgggag     4200

tcctggagat ctgaagtagg gaagcaactg aggccccttt atgaagagta cgtcgtactt     4260

aagaatgaaa tggcccgcgc taaccactac gaggattacg gcgattactg gcgtggggac     4320

tatgaagtaa atggtgtaga tggatacgac tatagtcgtg ggcaattgat tgaggatgtg     4380

gagcacactt ttgaggagat aaaaccactc tatgagcatc ttcacgcata tgtgagagct     4440

aaactgatga acgcctaccc aagttacatc agtccaatcg gatgtctccc agctcacctc     4500

cttggcgaca tgtggggact gttctggacc aatctgtatt ccctcacagt ccctttcggg     4560

caaaagccta atatagacgt gacagacgca atggttgatc aggcttggga tgctcaaagg     4620

atttttaagg aagctgagaa gttttttgtg tcagtcggtt tgccaaatat gacacaaggc     4680

ttctgggaaa atagcatgtt gactgatccc ggtaatgttc aaaaggctgt gtgtcaccct     4740

accgcttggg accttgggaa aggtgacttt cgaatcttga tgtgtaccaa ggtgacaatg     4800

gatgactttc ttacagccca tcatgaaatg ggtcacatcc agtatgatat ggcttatgca     4860

gctcaacctt tcctcttgag aaatggtgca aatgaaggtt ttcatgaagc tgtaggggaa     4920

ataatgtccc tgagtgctgc aaccccaaag catctcaaga gtatcggatt gttgagccca     4980

gattttcaag aagataacga gaccgaaatc aacttccttc tgaaacaagc cctcacaata     5040

gttggtactc ttccattcac atacatgctg gagaaatggc gttggatggt ttttaagggg     5100

gagataccta aagatcagtg gatgaaaaag tggtgggaga tgaagcgtga gatcgtaggg     5160

gtcgtggagc cagtgcctca tgatgagact tactgtgacc cagcatcact cttccacgtt     5220

agcaatgact attcatttat acgttattac actcgcactc tttaccagtt tcaatttcag     5280

gaggctctgt gtcaggctgc caagcatgag ggaccccttc acaagtgtga tattagtaac     5340

agtactgagg caggccaaaa actgttcaat atgttgaggc ttggcaaaag cgagccatgg     5400

actctcgcct tggaaaatgt tgtcggggct aaaaacatga atgtacgccc tctgcttaac     5460

tattttgagc ccctttttac atggctcaag gaccagaata agaactcctt tgtcggctgg     5520

tcaacagact ggtctcccta tgcagacaaa acacatactt gcccaccttg tcctgcacca     5580

gagctgctgg gaggtccaag cgtgttcctg tttccaccca agcccaaaga cacactgatg     5640

atttctcgaa ctccagaagt gacctgcgtg gtcgtggacg tgagccacga ggatcccgaa     5700

gtgaagttca actggtacgt ggatggcgtg gaggtccata atgctaagac taaaccccgg     5760

gaggaacagt acaacagcac ttatagggtc gtgtccgtgc tgaccgtcct gcatcaggat     5820

tggctgaacg ggaaggaata taagtgcaaa gtgtctaata aggcactgcc cgcccctatc     5880

gagaaaacaa ttagcaaggc taagggtcag cctagagaac cacaggtgta cactctgcct     5940

ccaagtcgcg acgagctgac caagaaccag gtgtcactga catgtctggt caaaggcttt     6000

tatccctcag atatcgcagt ggagtgggaa agcaatggac agcctgagaa caattacaag     6060

accacacccc ctgtgctgga cagtgatggc tcattctttc tgtattctaa gctgacagtg     6120

gacaaaagta ggtggcagca gggaaacgtg ttctcctgct ctgtcatgca cgaagcactg     6180

cacaatcatt atacccagaa gagtctgtca ctgagccctg gcaaatgagc gataccgatt     6240

ctagaactag atcataatca gccataccac atttgtagag gttttacttg ctttaaaaaa     6300

cctcccacac ctccccctga acctgaaaca taaaatgaat gcaattgttg ttgttaactt     6360

gtttattgca gcttataatg gttacaaata aagcaatagc atcacaaatt tcacaaataa     6420

agcatttttt tcactgcatt ctagttgtgg tttgtccaaa ctcatcaatg tatcttaagg     6480

ccgcaggtaa gccagcccag gcctcgccct ccagctcaag gcgggacagg tgccctagag     6540

tagcctgcat ccagggacag gccccagccg ggtgctgaca cgtccacctc catctcttcc     6600

tcaggtctgc ccgggtggca tccctgtgac ccctccccag tgcctctcct ggtcgtggaa     6660

ggtgctactc cagtgcccac cagccttgtc ctaataaaat taagttgcat cattttgttt     6720

gactaggtgt ccttgtataa tattatgggg tggaggcggg tggtatggag caaggggccc     6780

aagttaactt gtttattgca gcttataatg gttacaaata aagcaatagc atcacaaatt     6840

tcacaaataa agcatttttt tcactgcatt ctagttgtgg tttgtccaaa ctcatcaatg     6900

tatcttatca tgtctggatc cgcttcaggc accgggcttg cgggtcatgc accaggtgcg     6960

cggtccttcg ggcacctcga cgtcggcggt gacggtgaag ccgagccgct cgtagaaggg     7020

gaggttgcgg ggcgcggagg tctccaggaa ggcgggcacc ccggcgcgct cggccgcctc     7080

cactccgggg agcacgacgg cgctgcccag acccttgccc tggtggtcgg gcgagacgcc     7140

gacggtggcc aggaaccacg cgggctcctt gggccggtgc ggcgccagga ggccttccat     7200

ctgttgctgc gcggccagcc tggaaccgct caactcggcc atgcgcgggc cgatctcggc     7260

gaacaccgcc cccgcttcga cgctctccgg cgtggtccag accgccaccg cggcgccgtc     7320

gtccgcgacc cacaccttgc cgatgtcgag cccgacgcgc gtgaggaaga gttcttgcag     7380

ctcggtgacc cgctcgatgt ggcggtccgg gtcgacggtg tggcgcgtgg cggggtagtc     7440

ggcgaacgcg gcggcgaggg tgcgtacggc ccgggggacg tcgtcgcggg tggcgaggcg     7500

caccgtgggc ttgtactcgg tcatggtggc ctgcagagtc gctctgtgtt cgaggccaca     7560

cgcgtcacct taatatgcga agtggacctg ggaccgcgcc gccccgactg catctgcgtg     7620

ttttcgccaa tgacaagacg ctgggcgggg tttgtgtcat catagaacta aagacatgca     7680

aatatatttc ttccggggac accgccagca aacgcgagca acgggccacg gggatgaagc     7740

agctgcgcca ctccctgaag atccatcgtc tcctaacaag ttacatcact cctgcccttc     7800

ctcaccctca tctccatcac ctccttcatc tccgtcatct ccgtcatcac cctccgcggc     7860

agccccttcc accataggtg gaaaccaggg aggcaaatct actccatcgt caaagctgca     7920

cacagtcacc ctgatattgc aggtaggagc gggctttgtc ataacaaggt ccttaatcgc     7980

atccttcaaa acctcagcaa atatatgagt ttgtaaaaag accatgaaat aacagacaat     8040

ggactccctt agcgggccag gttgtgggcc gggtccaggg gccattccaa aggggagacg     8100

actcaatggt gtaagacgac attgtggaat agcaagggca gttcctcgcc ttaggttgta     8160

aagggaggtc ttactacctc catatacgaa cacaccggcg acccaagttc cttcgtcggt     8220

agtcctttct acgtgactcc tagccaggag agctcttaaa ccttctgcaa tgttctcaaa     8280

tttcgggttg gaacctcctt gaccacgatg ctttccaaac caccctcctt ttttgcgcct     8340

gcctccatca ccctgacccc cgctgcgcgg gggcacgtca ggctcaccat ctgggccgcc     8400

ttcttggtgg tattcaaaat aatcggcttc ccctacaggg tggaaaaatg gccttctacc     8460

tggagggggc ctgcgcggtg gagacccgga tgatgatgac tgactactgg gactcctggg     8520

cctcttttct ccacgtccac gacctctccc cctggctctt tcacgacttc cccccctggc     8580

tctttcacgt cctctacccc ggcggcctcc actacctcct cgaccccggc ctccactacc     8640

tcctcgaccc cggcctccac tgcctcctcg accccggcct ccacctcctg ctcctgcccc     8700

tcccgctcct gctcctgctc ctgttccacc gtgggtccct ttgcagccaa tgcaacttgg     8760

acgtttttgg ggtctccgga caccatctct atgtcttggc cctgatcctg agccgcccgg     8820

ggctcctggt cttccgcctc ctcgtcctcg tcctcttccc cgtcctcgtc catgtgccat     8880

gatggcggcc tgcagctgtg ttcgaggccg cgcgtgtcac cttaatatgc gaagtggacc     8940

tgggaccgcg ccgccccgac tgcatctgcg tgttcgagtt cgccaatgac aagacgctgg     9000

gcggggagat cccccttatt aaccctaaac gggtagcata tgcttcccgg gtagtagtat     9060

atactatcca gactaaccct aattcaatag catatgttac ccaacgggaa gcatatgcta     9120

tcgaattagg gttagtaaaa gggtcctaag gaacagcgat ctggatagca tatgctatcc     9180

taatctatat ctgggtagca tatgctatcc taatctatat ctgggtagca taggctatcc     9240

taatctatat ctgggtagca tatgctatcc taatctatat ctgggtagta tatgctatcc     9300

taatttatat ctgggtagca taggctatcc taatctatat ctgggtagca tatgctatcc     9360

taatctatat ctgggtagta tatgctatcc taatctgtat ccgggtagca tatgctatcc     9420

tcatgcatat acagtcagca tatgataccc agtagtagag tgggagtgct atcctttgca     9480

tatgccgcca cctcccaagg agatctgtcg acatcgatgg gcgcgggtgt acactccgcc     9540

catcccgccc ctaactccgc ccagttccgc ccattctccg cctcatggct gactaatttt     9600

ttttatttat gcagaggccg aggccgcctc ggcctctgag ctattccaga agtagtgagg     9660

aggctttttt ggaggcctag gcttttgcaa aaagctaatt c                         9701


<210>  224
<211>  38496
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  vector for IgA against T27Y H34A H505L ACE2 mutant

<400>  224
tattattgat gatgttaatt aacatgcatg gatcctacgt ctcgaccgat gcccttgaga       60

gccttcaacc cagtcagctc cttccggtgg gcgcggggca tgactatcgt cgccgcactt      120

atgactgtct tctttatcat gcaactcgta ggacaggtgc cggcagcgct ctgggtcatt      180

ttcggcgagg accgctttcg ctggagcgcg acgatgatcg gcctgtcgct tgcggtattc      240

ggaatcttgc acgccctcgc tcaagccttc gtcactggtc ccgccaccaa acgtttcggc      300

gagaagcagg ccattatcgc cggcatggcg gccgacgcgc tgggctacgt cttgctggcg      360

ttcgcgacgc gaggctggat ggccttcccc attatgattc ttctcgcttc cggcggcatc      420

gggatgcccg cgttgcaggc catgctgtcc aggcaggtag atgacgacca tcagggacag      480

cttcaaggat cgctcgcggc tcttaccagc ctaacttcga tcattggacc gctgatcgtc      540

acggcgattt atgccgcctc ggcgagcaca tggaacgggt tggcatggat tgtaggcgcc      600

gccctatacc ttgtctgcct ccccgcgttg cgtcgcggtg catggagccg ggccacctcg      660

acctgaatgg aagccggcgg cacctcgcta acggattcac cactccaaga attggagcca      720

atcaattctt gcggagaact gtgaatgcgc aaaccaaccc ttggcagaac atatccatcg      780

cgtccgccat ctccagcagc cgcacgcggc gcatctcggg cagcgttggg tcctggccac      840

gggtgcgcat gatcgtgctc ctgtcgttga ggacccggct aggctggcgg ggttgcctta      900

ctggttagca gaatgaatca ccgatacgcg agcgaacgtg aagcgactgc tgctgcaaaa      960

cgtctgcgac ctgagcaaca acatgaatgg tcttcggttt ccgtgtttcg taaagtctgg     1020

aaacgcggaa gtcagcgccc tgcaccatta tgttccggat ctgcatcgca ggatgctgct     1080

ggctaccctg tggaacacct acatctgtat taacgaagcg ctggcattga ccctgagtga     1140

tttttctctg gtcccgccgc atccataccg ccagttgttt accctcacaa cgttccagta     1200

accgggcatg ttcatcatca gtaacccgta tcgtgagcat cctctctcgt ttcatcggta     1260

tcattacccc catgaacaga aatccccctt acacggaggc atcagtgacc aaacaggaaa     1320

aaaccgccct taacatggcc cgctttatca gaagccagac attaacgctt ctggagaaac     1380

tcaacgagct ggacgcggat gaacaggcag acatctgtga atcgcttcac gaccacgctg     1440

atgagcttta ccgcagctgc ctcgcgcgtt tcggtgatga cggtgaaaac ctctgacaca     1500

tgcagctccc ggagacggtc acagcttgtc tgtaagcgga tgccgggagc agacaagccc     1560

gtcagggcgc gtcagcgggt gttggcgggt gtcggggcgc agccatgacc cagtcacgta     1620

gcgatagcgg agtgtatact ggcttaacta tgcggcatca gagcagattg tactgagagt     1680

gcaccatatg cggtgtgaaa taccgcacag atgcgtaagg agaaaatacc gcatcaggcg     1740

ctcttccgct tcctcgctca ctgactcgct gcgctcggtc gttcggctgc ggcgagcggt     1800

atcagctcac tcaaaggcgg taatacggtt atccacagaa tcaggggata acgcaggaaa     1860

gaacatgtga gcaaaaggcc agcaaaaggc caggaaccgt aaaaaggccg cgttgctggc     1920

gtttttccat aggctccgcc cccctgacga gcatcacaaa aatcgacgct caagtcagag     1980

gtggcgaaac ccgacaggac tataaagata ccaggcgttt ccccctggaa gctccctcgt     2040

gcgctctcct gttccgaccc tgccgcttac cggatacctg tccgcctttc tcccttcggg     2100

aagcgtggcg ctttctcata gctcacgctg taggtatctc agttcggtgt aggtcgttcg     2160

ctccaagctg ggctgtgtgc acgaaccccc cgttcagccc gaccgctgcg ccttatccgg     2220

taactatcgt cttgagtcca acccggtaag acacgactta tcgccactgg cagcagccac     2280

tggtaacagg attagcagag cgaggtatgt aggcggtgct acagagttct tgaagtggtg     2340

gcctaactac ggctacacta gaaggacagt atttggtatc tgcgctctgc tgaagccagt     2400

taccttcgga aaaagagttg gtagctcttg atccggcaaa caaaccaccg ctggtagcgg     2460

tggttttttt gtttgcaagc agcagattac gcgcagaaaa aaaggatctc aagaagatcc     2520

tttgatcttt tctacggggt ctgacgctca gtggaacgaa aactcacgtt aagggatttt     2580

ggtcatgaga ttatcaaaaa ggatcttcac ctagatcctt ttaaattaaa aatgaagttt     2640

taaatcaatc taaagtatat atgagtaaac ttggtctgac agttaccaat gcttaatcag     2700

tgaggcacct atctcagcga tctgtctatt tcgttcatcc atagttgcct gactccccgt     2760

cgtgtagata actacgatac gggagggctt accatctggc cccagtgctg caatgatacc     2820

gcgagaccca cgctcaccgg ctccagattt atcagcaata aaccagccag ccggaagggc     2880

cgagcgcaga agtggtcctg caactttatc cgcctccatc cagtctatta attgttgccg     2940

ggaagctaga gtaagtagtt cgccagttaa tagtttgcgc aacgttgttg ccattgctgc     3000

agccatgaga ttatcaaaaa ggatcttcac ctagatcctt ttcacgtaga aagccagtcc     3060

gcagaaacgg tgctgacccc ggatgaatgt cagctactgg gctatctgga caagggaaaa     3120

cgcaagcgca aagagaaagc aggtagcttg cagtgggctt acatggcgat agctagactg     3180

ggcggtttta tggacagcaa gcgaaccgga attgccagct ggggcgccct ctggtaaggt     3240

tgggaagccc tgcaaagtaa actggatggc tttcttgccg ccaaggatct gatggcgcag     3300

gggatcaagc tctgatcaag agacaggatg aggatcgttt cgcatgattg aacaagatgg     3360

attgcacgca ggttctccgg ccgcttgggt ggagaggcta ttcggctatg actgggcaca     3420

acagacaatc ggctgctctg atgccgccgt gttccggctg tcagcgcagg ggcgcccggt     3480

tctttttgtc aagaccgacc tgtccggtgc cctgaatgaa ctgcaagacg aggcagcgcg     3540

gctatcgtgg ctggccacga cgggcgttcc ttgcgcagct gtgctcgacg ttgtcactga     3600

agcgggaagg gactggctgc tattgggcga agtgccgggg caggatctcc tgtcatctca     3660

ccttgctcct gccgagaaag tatccatcat ggctgatgca atgcggcggc tgcatacgct     3720

tgatccggct acctgcccat tcgaccacca agcgaaacat cgcatcgagc gagcacgtac     3780

tcggatggaa gccggtcttg tcgatcagga tgatctggac gaagagcatc aggggctcgc     3840

gccagccgaa ctgttcgcca ggctcaaggc gagcatgccc gacggcgagg atctcgtcgt     3900

gacccatggc gatgcctgct tgccgaatat catggtggaa aatggccgct tttctggatt     3960

catcgactgt ggccggctgg gtgtggcgga ccgctatcag gacatagcgt tggctacccg     4020

tgatattgct gaagagcttg gcggcgaatg ggctgaccgc ttcctcgtgc tttacggtat     4080

cgccgctccc gattcgcagc gcatcgcctt ctatcgcctt cttgacgagt tcttctgaat     4140

tttgttaaaa tttttgttaa atcagctcat tttttaacca ataggccgaa atcggcaaaa     4200

tcccttataa atcaaaagaa tagaccgaga tagggttgag tgttgttcca gtttggaaca     4260

agagtccact attaaagaac gtggactcca acgtcaaagg gcgaaaaacc gtctatcagg     4320

gcgatggccc actacgtgaa ccatcaccct aatcaagttt tttggggtcg aggtgccgta     4380

aagcactaaa tcggaaccct aaagggagcc cccgatttag agcttgacgg ggaaagccgg     4440

cgaacgtggc gagaaaggaa gggaagaaag cgaaaggagc gggcgctagg gcgctggcaa     4500

gtgtagcggt cacgctgcgc gtaaccacca cacccgccgc gcttaatgcg ccgctacagg     4560

gcgcgtccat tcgccattca ggatcgaatt aattcttaat taacatcatc aataatatac     4620

cttattttgg attgaagcca atatgataat gagggggtgg agtttgtgac gtggcgcggg     4680

gcgtgggaac ggggcgggtg acgtagtagt gtggcggaag tgtgatgttg caagtgtggc     4740

ggaacacatg taagcgacgg atgtggcaaa agtgacgttt ttggtgtgcg ccggtgtaca     4800

caggaagtga caattttcgc gcggttttag gcggatgttg tagtaaattt gggcgtaacc     4860

gagtaagatt tggccatttt cgcgggaaaa ctgaataaga ggaagtgaaa tctgaataat     4920

tttgtgttac tcatagcgcg taatactgta atagtaatca attacggggt cattagttca     4980

tagcccatat atggagttcc gcgttacata acttacggta aatggcccgc ctggctgacc     5040

gcccaacgac ccccgcccat tgacgtcaat aatgacgtat gttcccatag taacgccaat     5100

agggactttc cattgacgtc aatgggtgga gtatttacgg taaactgccc acttggcagt     5160

acatcaagtg tatcatatgc caagtacgcc ccctattgac gtcaatgacg gtaaatggcc     5220

cgcctggcat tatgcccagt acatgacctt atgggacttt cctacttggc agtacatcta     5280

cgtattagtc atcgctatta ccatggtgat gcggttttgg cagtacatca atgggcgtgg     5340

atagcggttt gactcacggg gatttccaag tctccacccc attgacgtca atgggagttt     5400

gttttggcac caaaatcaac gggactttcc aaaatgtcgt aacaactccg ccccattgac     5460

gcaaatgggc ggtaggcgtg tacggtggga ggtctatata agcagagctg gtttagtgaa     5520

ccgtcagatc cgctagagat ctggtaccgt cgacgcggcc gctcgagcct aagcttatga     5580

gcagcagtag ttggcttctc ttgagtttgg tggcagtgac agcagcccag agtactatcg     5640

aggagcaggc taaatacttt ctggataagt ttaacgccga ggccgaagac ttgttctatc     5700

aatcttctct cgcttcatgg aattacaata ctaacatcac tgaggagaac gtccagaata     5760

tgaacaatgc tggcgacaaa tggagcgcct tcttgaagga gcagtctacc cttgcacaaa     5820

tgtatccact gcaggagata cagaacctta cagtaaagtt gcagctccag gctctccagc     5880

agaacggatc tagcgtgctt tcagaggata aaagcaaaag gctgaacacc atacttaata     5940

ccatgtccac aatttactct actggtaaag tatgtaaccc cgacaaccct caagaatgcc     6000

tccttcttga gccaggcctc aatgagatca tggctaatag tctggactat aatgaaagac     6060

tgtgggcatg ggagtcctgg agatctgaag tagggaagca actgaggccc ctttatgaag     6120

agtacgtcgt acttaagaat gaaatggccc gcgctaacca ctacgaggat tacggcgatt     6180

actggcgtgg ggactatgaa gtaaatggtg tagatggata cgactatagt cgtgggcaat     6240

tgattgagga tgtggagcac acttttgagg agataaaacc actctatgag catcttcacg     6300

catatgtgag agctaaactg atgaacgcct acccaagtta catcagtcca atcggatgtc     6360

tcccagctca cctccttggc gacatgtggg gacgtttctg gaccaatctg tattccctca     6420

cagtcccttt cgggcaaaag cctaatatag acgtgacaga cgcaatggtt gatcaggctt     6480

gggatgctca aaggattttt aaggaagctg agaagttttt tgtgtcagtc ggtttgccaa     6540

atatgacaca aggcttctgg gaaaatagca tgttgactga tcccggtaat gttcaaaagg     6600

ctgtgtgtca ccctaccgct tgggaccttg ggaaaggtga ctttcgaatc ttgatgtgta     6660

ccaaggtgac aatggatgac tttcttacag cccatcatga aatgggtcac atccagtatg     6720

atatggctta tgcagctcaa cctttcctct tgagaaatgg tgcaaatgaa ggttttcatg     6780

aagctgtagg ggaaataatg tccctgagtg ctgcaacccc aaagcatctc aagagtatcg     6840

gattgttgag cccagatttt caagaagata acgagaccga aatcaacttc cttctgaaac     6900

aagccctcac aatagttggt actcttccat tcacatacat gctggagaaa tggcgttgga     6960

tggtttttaa gggggagata cctaaagatc agtggatgaa aaagtggtgg gagatgaagc     7020

gtgagatcgt aggggtcgtg gagccagtgc ctcatgatga gacttactgt gacccagcat     7080

cactcttcct ggttagcaat gactattcat ttatacgtta ttacactcgc actctttacc     7140

agtttcaatt tcaggaggct ctgtgtcagg ctgccaagca tgagggaccc cttcacaagt     7200

gtgatattag taacagtact gaggcaggcc aaaaactgtt caatatgttg aggcttggca     7260

aaagcgagcc atggactctc gccttggaaa atgttgtcgg ggctaaaaac atgaatgtac     7320

gccctctgct taactatttt gagccccttt ttacatggct caaggaccag aataagaact     7380

cctttgtcgg ctggtcaaca gactggtctc cctatgcaga ccctagtact cctcctactc     7440

cttctccatc aaccccacca actccatccc ctagctgctg tcacccaagg ctgtctctgc     7500

accgacctgc actcgaagac cttctgttgg gctctgaagc taacctgacc tgtactctta     7560

ctggcttgcg cgatgctagc ggcgtgactt tcacctggac acctagtagc ggtaaaagtg     7620

ctgtacaagg acctcctgaa cgcgacctgt gtggttgcta ctctgtgtct tctgtacttc     7680

ccggctgtgc cgagccctgg aatcacggga aaacctttac ctgcaccgcc gcttaccctg     7740

agtcaaaaac tcccctcact gccacattga gtaagtcagg gaatacattc aggccagagg     7800

ttcatttgtt gcctcctcca tctgaagaac ttgctttgaa cgagctggtc actctgacct     7860

gcttggctag gggtttctcc cccaaagatg tacttgtacg gtggttgcag ggcagccaag     7920

agttgccccg cgaaaagtat ttgacctggg cctcaagaca agaacccagc caggggacta     7980

ccacatttgc cgtgaccagt attctgcgtg tagccgctga agattggaag aaaggggata     8040

cattttcttg catggtaggg catgaggccc ttcccctcgc tttcactcag aagacaatag     8100

acagactcgc cggaaagcct actcacgtga atgttagcgt agtcatggct gaggttgacg     8160

gaacttgcta ctgagatatc cgatccaccg gatctagata actgatcata atcagccata     8220

ccacatttgt agaggtttta cttgctttaa aaaacctccc acacctcccc ctgaacctga     8280

aacataaaat gaatgcaatt gttgttgtta acttgtttat tgcagcttat aatggttaca     8340

aataaagcaa tagcatcaca aatttcacaa ataaagcatt tttttcactg cattctagtt     8400

gtggtttgtc caaactcatc aatgtatctt aggtttagtg aaccgtcaga tccgctagcg     8460

ttacataact tacggtaaat ggcccgcctg gctgaccgcc caacgacccc cgcccattga     8520

cgtcaataat gacgtatgtt cccatagtaa cgccaatagg gactttccat tgacgtcaat     8580

gggtggagta tttacggtaa actgcccact tggcagtaca tcaagtgtat catatgccaa     8640

gtacgccccc tattgacgtc aatgacggta aatggcccgc ctggcattat gcccagtaca     8700

tgaccttatg ggactttcct acttggcagt acatctacgt attagtcatc gctattacca     8760

tggtgatgcg gttttggcag tacatcaatg ggcgtggata gcggtttgac tcacggggat     8820

ttccaagtct ccaccccatt gacgtcaatg ggagtttgtt ttggcaccaa aatcaacggg     8880

actttccaaa atgtcgtaac aactccgccc cattgacgca aatgggcggt aggcgtgtac     8940

ggtgggaggt ctatataagc agagctggtt tagtgaaccg tcagatccgc tagagatctg     9000

gtaccgtcga cgcggccgct cgagcctaag cttatgaaga accatctgct tttctgggga     9060

gtacttgccg ttttcataaa agccgtacat gttaaagcac aagaggacga acgcattgtg     9120

ttggttgata ataaatgcaa atgtgctcgg ataacatctc ggatcattcg tagctcagag     9180

gaccccaatg aggatatagt agagcgaaac atcagaatta tagtacccct gaacaacaga     9240

gagaacataa gtgatcccac aagtccattg cggacacgct ttgtttacca tttgtctgat     9300

ctgtgtaaaa aatgtgatcc aacagaggtg gaactcgaca atcagatcgt caccgccacc     9360

cagtctaaca tctgcgatga agattcagct acagagacat gctacacata cgaccggaac     9420

aagtgctata ctgccgttgt gccactcgtt tacggtggag aaacaaagat ggttgaaact     9480

gcacttacac cagatgcctg ctatccagat tgagatatcc gatccaccgg atctagataa     9540

ctgatcataa tcagccatac cacatttgta gaggttttac ttgctttaaa aaacctccca     9600

cacctccccc tgaacctgaa acataaaatg aatgcaattg ttgttgttaa cttgtttatt     9660

gcagcttata atggttacaa ataaagcaat agcatcacaa atttcacaaa taaagcattt     9720

ttttcactgc attctagttg tggtttgtcc aaactcatca atgtatctta acgcggatct     9780

gggcgtggtt aagggtggga aagaatatat aaggtggggg tcttatgtag ttttgtatct     9840

gttttgcagc agccgccgcc gccatgagca ccaactcgtt tgatggaagc attgtgagct     9900

catatttgac aacgcgcatg cccccatggg ccggggtgcg tcagaatgtg atgggctcca     9960

gcattgatgg tcgccccgtc ctgcccgcaa actctactac cttgacctac gagaccgtgt    10020

ctggaacgcc gttggagact gcagcctccg ccgccgcttc agccgctgca gccaccgccc    10080

gcgggattgt gactgacttt gctttcctga gcccgcttgc aagcagtgca gcttcccgtt    10140

catccgcccg cgatgacaag ttgacggctc ttttggcaca attggattct ttgacccggg    10200

aacttaatgt cgtttctcag cagctgttgg atctgcgcca gcaggtttct gccctgaagg    10260

cttcctcccc tcccaatgcg gtttaaaaca taaataaaaa accagactct gtttggattt    10320

ggatcaagca agtgtcttgc tgtctttatt taggggtttt gcgcgcgcgg taggcccggg    10380

accagcggtc tcggtcgttg agggtcctgt gtattttttc caggacgtgg taaaggtgac    10440

tctggatgtt cagatacatg ggcataagcc cgtctctggg gtggaggtag caccactgca    10500

gagcttcatg ctgcggggtg gtgttgtaga tgatccagtc gtagcaggag cgctgggcgt    10560

ggtgcctaaa aatgtctttc agtagcaagc tgattgccag gggcaggccc ttggtgtaag    10620

tgtttacaaa gcggttaagc tgggatgggt gcatacgtgg ggatatgaga tgcatcttgg    10680

actgtatttt taggttggct atgttcccag ccatatccct ccggggattc atgttgtgca    10740

gaaccaccag cacagtgtat ccggtgcact tgggaaattt gtcatgtagc ttagaaggaa    10800

atgcgtggaa gaacttggag acgcccttgt gacctccaag attttccatg cattcgtcca    10860

taatgatggc aatgggccca cgggcggcgg cctgggcgaa gatatttctg ggatcactaa    10920

cgtcatagtt gtgttccagg atgagatcgt cataggccat ttttacaaag cgcgggcgga    10980

gggtgccaga ctgcggtata atggttccat ccggcccagg ggcgtagtta ccctcacaga    11040

tttgcatttc ccacgctttg agttcagatg gggggatcat gtctacctgc ggggcgatga    11100

agaaaacggt ttccggggta ggggagatca gctgggaaga aagcaggttc ctgagcagct    11160

gcgacttacc gcagccggtg ggcccgtaaa tcacacctat taccggctgc aactggtagt    11220

taagagagct gcagctgccg tcatccctga gcaggggggc cacttcgtta agcatgtccc    11280

tgactcgcat gttttccctg accaaatccg ccagaaggcg ctcgccgccc agcgatagca    11340

gttcttgcaa ggaagcaaag tttttcaacg gtttgagacc gtccgccgta ggcatgcttt    11400

tgagcgtttg accaagcagt tccaggcggt cccacagctc ggtcacctgc tctacggcat    11460

ctcgatccag catatctcct cgtttcgcgg gttggggcgg ctttcgctgt acggcagtag    11520

tcggtgctcg tccagacggg ccagggtcat gtctttccac gggcgcaggg tcctcgtcag    11580

cgtagtctgg gtcacggtga aggggtgcgc tccgggctgc gcgctggcca gggtgcgctt    11640

gaggctggtc ctgctggtgc tgaagcgctg ccggtcttcg ccctgcgcgt cggccaggta    11700

gcatttgacc atggtgtcat agtccagccc ctccgcggcg tggcccttgg cgcgcagctt    11760

gcccttggag gaggcgccgc acgaggggca gtgcagactt ttgagggcgt agagcttggg    11820

cgcgagaaat accgattccg gggagtaggc atccgcgccg caggccccgc agacggtctc    11880

gcattccacg agccaggtga gctctggccg ttcggggtca aaaaccaggt ttcccccatg    11940

ctttttgatg cgtttcttac ctctggtttc catgagccgg tgtccacgct cggtgacgaa    12000

aaggctgtcc gtgtccccgt atacagactt gagaggcctg tcctcgagcg gtgttccgcg    12060

gtcctcctcg tatagaaact cggaccactc tgagacaaag gctcgcgtcc aggccagcac    12120

gaaggaggct aagtgggagg ggtagcggtc gttgtccact agggggtcca ctcgctccag    12180

ggtgtgaaga cacatgtcgc cctcttcggc atcaaggaag gtgattggtt tgtaggtgta    12240

ggccacgtga ccgggtgttc ctgaaggggg gctataaaag ggggtggggg cgcgttcgtc    12300

ctcactctct tccgcatcgc tgtctgcgag ggccagctgt tggggtgagt actccctctg    12360

aaaagcgggc atgacttctg cgctaagatt gtcagtttcc aaaaacgagg aggatttgat    12420

attcacctgg cccgcggtga tgcctttgag ggtggccgca tccatctggt cagaaaagac    12480

aatctttttg ttgtcaagct tggtggcaaa cgacccgtag agggcgttgg acagcaactt    12540

ggcgatggag cgcagggttt ggtttttgtc gcgatcggcg cgctccttgg ccgcgatgtt    12600

tagctgcacg tattcgcgcg caacgcaccg ccattcggga aagacggtgg tgcgctcgtc    12660

gggcaccagg tgcacgcgcc aaccgcggtt gtgcagggtg acaaggtcaa cgctggtggc    12720

tacctctccg cgtaggcgct cgttggtcca gcagaggcgg ccgcccttgc gcgagcagaa    12780

tggcggtagg gggtctagct gcgtctcgtc cggggggtct gcgtccacgg taaagacccc    12840

gggcagcagg cgcgcgtcga agtagtctat cttgcatcct tgcaagtcta gcgcctgctg    12900

ccatgcgcgg gcggcaagcg cgcgctcgta tgggttgagt gggggacccc atggcatggg    12960

gtgggtgagc gcggaggcgt acatgccgca aatgtcgtaa acgtagaggg gctctctgag    13020

tattccaaga tatgtagggt agcatcttcc accgcggatg ctggcgcgca cgtaatcgta    13080

tagttcgtgc gagggagcga ggaggtcggg accgaggttg ctacgggcgg gctgctctgc    13140

tcggaagact atctgcctga agatggcatg tgagttggat gatatggttg gacgctggaa    13200

gacgttgaag ctggcgtctg tgagacctac cgcgtcacgc acgaaggagg cgtaggagtc    13260

gcgcagcttg ttgaccagct cggcggtgac ctgcacgtct agggcgcagt agtccagggt    13320

ttccttgatg atgtcatact tatcctgtcc cttttttttc cacagctcgc ggttgaggac    13380

aaactcttcg cggtctttcc agtactcttg gatcggaaac ccgtcggcct ccgaacggta    13440

agagcctagc atgtagaact ggttgacggc ctggtaggcg cagcatccct tttctacggg    13500

tagcgcgtat gcctgcgcgg ccttccggca tgaccagcat gaagggcacg agctgcttcc    13560

caaaggcccc catccaagta taggtctcta catcgtaggt gacaaagaga cgctcggtgc    13620

gaggatgcga gccgatcggg aagaactgga tctcccgcca ccaattggag gagtggctat    13680

tgatgtggtg aaagtagaag tccctgcgac gggccgaaca ctcgtgctgg cttttgtaaa    13740

aacgtgcgca gtactggcag cggtgcacgg gctgtacatc ctgcacgagg ttgacctgac    13800

gaccgcgcac aaggaagcag agtgggaatt tgagcccctc gcctggcggg tttggctggt    13860

ggtcttctac ttcggctgct tgtccttgac cgtctggctg ctcgagggga gttacggtgg    13920

atcggaccac cacgccgcgc gagcccaaag tccagatgtc cgcgcgcggc ggtcggagct    13980

tgatgacaac atcgcgcaga tgggagctgt ccatggtctg gagctcccgc ggcgtcaggt    14040

caggcgggag ctcctgcagg tttacctcgc atagacgggt cagggcgcgg gctagatcca    14100

ggtgatacct aatttccagg ggctggttgg tggcggcgtc gatggcttgc aagaggccgc    14160

atccccgcgg cgcgactacg gtaccgcgcg gcgggcggtg ggccgcgggg gtgtccttgg    14220

atgatgcatc taaaagcggt gacgcgggcg agcccccgga ggtagggggg gctccggacc    14280

cgccgggaga gggggcaggg gcacgtcggc gccgcgcgcg ggcaggagct ggtgctgcgc    14340

gcgtaggttg ctggcgaacg cgacgacgcg gcggttgatc tcctgaatct ggcgcctctg    14400

cgtgaagacg acgggcccgg tgagcttgaa cctgaaagag agttcgacag aatcaatttc    14460

ggtgtcgttg acggcggcct ggcgcaaaat ctcctgcacg tctcctgagt tgtcttgata    14520

ggcgatctcg gccatgaact gctcgatctc ttcctcctgg agatctccgc gtccggctcg    14580

ctccacggtg gcggcgaggt cgttggaaat gcgggccatg agctgcgaga aggcgttgag    14640

gcctccctcg ttccagacgc ggctgtagac cacgccccct tcggcatcgc gggcgcgcat    14700

gaccacctgc gcgagattga gctccacgtg ccgggcgaag acggcgtagt ttcgcaggcg    14760

ctgaaagagg tagttgaggg tggtggcggt gtgttctgcc acgaagaagt acataaccca    14820

gcgtcgcaac gtggattcgt tgataattgt tgtgtaggta ctccgccgcc gagggacctg    14880

agcgagtccg catcgaccgg atcggaaaac ctctcgagaa aggcgtctaa ccagtcacag    14940

tcgcaaggta ggctgagcac cgtggcgggc ggcagcgggc ggcggtcggg gttgtttctg    15000

gcggaggtgc tgctgatgat gtaattaaag taggcggtct tgagacggcg gatggtcgac    15060

agaagcacca tgtccttggg tccggcctgc tgaatgcgca ggcggtcggc catgccccag    15120

gcttcgtttt gacatcggcg caggtctttg tagtagtctt gcatgagcct ttctaccggc    15180

acttcttctt ctccttcctc ttgtcctgca tctcttgcat ctatcgctgc ggcggcggcg    15240

gagtttggcc gtaggtggcg ccctcttcct cccatgcgtg tgaccccgaa gcccctcatc    15300

ggctgaagca gggctaggtc ggcgacaacg cgctcggcta atatggcctg ctgcacctgc    15360

gtgagggtag actggaagtc atccatgtcc acaaagcggt ggtatgcgcc cgtgttgatg    15420

gtgtaagtgc agttggccat aacggaccag ttaacggtct ggtgacccgg ctgcgagagc    15480

tcggtgtacc tgagacgcga gtaagccctc gagtcaaata cgtagtcgtt gcaagtccgc    15540

accaggtact ggtatcccac caaaaagtgc ggcggcggct ggcggtagag gggccagcgt    15600

agggtggccg gggctccggg ggcgagatct tccaacataa ggcgatgata tccgtagatg    15660

tacctggaca tccaggtgat gccggcggcg gtggtggagg cgcgcggaaa gtcgcggacg    15720

cggttccaga tgttgcgcag cggcaaaaag tgctccatgg tcgggacgct ctggccggtc    15780

aggcgcgcgc aatcgttgac gctctagcgt gcaaaaggag agcctgtaag cgggcactct    15840

tccgtggtct ggtggataaa ttcgcaaggg tatcatggcg gacgaccggg gttcgagccc    15900

cgtatccggc cgtccgccgt gatccatgcg gttaccgccc gcgtgtcgaa cccaggtgtg    15960

cgacgtcaga caacggggga gtgctccttt tggcttcctt ccaggcgcgg cggctgctgc    16020

gctagctttt ttggccactg gccgcgcgca gcgtaagcgg ttaggctgga aagcgaaagc    16080

attaagtggc tcgctccctg tagccggagg gttattttcc aagggttgag tcgcgggacc    16140

cccggttcga gtctcggacc ggccggactg cggcgaacgg gggtttgcct ccccgtcatg    16200

caagaccccg cttgcaaatt cctccggaaa cagggacgag cccctttttt gcttttccca    16260

gatgcatccg gtgctgcggc agatgcgccc ccctcctcag cagcggcaag agcaagagca    16320

gcggcagaca tgcagggcac cctcccctcc tcctaccgcg tcaggagggg cgacatccgc    16380

ggttgacgcg gcagcagatg gtgattacga acccccgcgg cgccgggccc ggcactacct    16440

ggacttggag gagggcgagg gcctggcgcg gctaggagcg ccctctcctg agcggcaccc    16500

aagggtgcag ctgaagcgtg atacgcgtga ggcgtacgtg ccgcggcaga acctgtttcg    16560

cgaccgcgag ggagaggagc ccgaggagat gcgggatcga aagttccacg cagggcgcga    16620

gctgcggcat ggcctgaatc gcgagcggtt gctgcgcgag gaggactttg agcccgacgc    16680

gcgaaccggg attagtcccg cgcgcgcaca cgtggcggcc gccgacctgg taaccgcata    16740

cgagcagacg gtgaaccagg agattaactt tcaaaaaagc tttaacaacc acgtgcgtac    16800

gcttgtggcg cgcgaggagg tggctatagg actgatgcat ctgtgggact ttgtaagcgc    16860

gctggagcaa aacccaaata gcaagccgct catggcgcag ctgttcctta tagtgcagca    16920

cagcagggac aacgaggcat tcagggatgc gctgctaaac atagtagagc ccgagggccg    16980

ctggctgctc gatttgataa acatcctgca gagcatagtg gtgcaggagc gcagcttgag    17040

cctggctgac aaggtggccg ccatcaacta ttccatgctt agcctgggca agttttacgc    17100

ccgcaagata taccataccc cttacgttcc catagacaag gaggtaaaga tcgaggggtt    17160

ctacatgcgc atggcgctga aggtgcttac cttgagcgac gacctgggcg tttatcgcaa    17220

cgagcgcatc cacaaggccg tgagcgtgag ccggcggcgc gagctcagcg accgcgagct    17280

gatgcacagc ctgcaaaggg ccctggctgg cacgggcagc ggcgatagag aggccgagtc    17340

ctactttgac gcgggcgctg acctgcgctg ggccccaagc cgacgcgccc tggaggcagc    17400

tggggccgga cctgggctgg cggtggcacc cgcgcgcgct ggcaacgtcg gcggcgtgga    17460

ggaatatgac gaggacgatg agtacgagcc agaggacggc gagtactaag cggtgatgtt    17520

tctgatcaga tgatgcaaga cgcaacggac ccggcggtgc gggcggcgct gcagagccag    17580

ccgtccggcc ttaactccac ggacgactgg cgccaggtca tggaccgcat catgtcgctg    17640

actgcgcgca atcctgacgc gttccggcag cagccgcagg ccaaccggct ctccgcaatt    17700

ctggaagcgg tggtcccggc gcgcgcaaac cccacgcacg agaaggtgct ggcgatcgta    17760

aacgcgctgg ccgaaaacag ggccatccgg cccgacgagg ccggcctggt ctacgacgcg    17820

ctgcttcagc gcgtggctcg ttacaacagc ggcaacgtgc agaccaacct ggaccggctg    17880

gtgggggatg tgcgcgaggc cgtggcgcag cgtgagcgcg cgcagcagca gggcaacctg    17940

ggctccatgg ttgcactaaa cgccttcctg agtacacagc ccgccaacgt gccgcgggga    18000

caggaggact acaccaactt tgtgagcgca ctgcggctaa tggtgactga gacaccgcaa    18060

agtgaggtgt accagtctgg gccagactat tttttccaga ccagtagaca aggcctgcag    18120

accgtaaacc tgagccaggc tttcaaaaac ttgcaggggc tgtggggggt gcgggctccc    18180

acaggcgacc gcgcgaccgt gtctagcttg ctgacgccca actcgcgcct gttgctgctg    18240

ctaatagcgc ccttcacgga cagtggcagc gtgtcccggg acacatacct aggtcacttg    18300

ctgacactgt accgcgaggc cataggtcag gcgcatgtgg acgagcatac tttccaggag    18360

attacaagtg tcagccgcgc gctggggcag gaggacacgg gcagcctgga ggcaacccta    18420

aactacctgc tgaccaaccg gcggcagaag atcccctcgt tgcacagttt aaacagcgag    18480

gaggagcgca ttttgcgcta cgtgcagcag agcgtgagcc ttaacctgat gcgcgacggg    18540

gtaacgccca gcgtggcgct ggacatgacc gcgcgcaaca tggaaccggg catgtatgcc    18600

tcaaaccggc cgtttatcaa ccgcctaatg gactacttgc atcgcgcggc cgccgtgaac    18660

cccgagtatt tcaccaatgc catcttgaac ccgcactggc taccgccccc tggtttctac    18720

accgggggat tcgaggtgcc cgagggtaac gatggattcc tctgggacga catagacgac    18780

agcgtgtttt ccccgcaacc gcagaccctg ctagagttgc aacagcgcga gcaggcagag    18840

gcggcgctgc gaaaggaaag cttccgcagg ccaagcagct tgtccgatct aggcgctgcg    18900

gccccgcggt cagatgctag tagcccattt ccaagcttga tagggtctct taccagcact    18960

cgcaccaccc gcccgcgcct gctgggcgag gaggagtacc taaacaactc gctgctgcag    19020

ccgcagcgcg aaaaaaacct gcctccggca tttcccaaca acgggataga gagcctagtg    19080

gacaagatga gtagatggaa gacgtacgcg caggagcaca gggacgtgcc aggcccgcgc    19140

ccgcccaccc gtcgtcaaag gcacgaccgt cagcggggtc tggtgtggga ggacgatgac    19200

tcggcagacg acagcagcgt cctggatttg ggagggagtg gcaacccgtt tgcgcacctt    19260

cgccccaggc tggggagaat gttttaaaaa aaaaaaagca tgatgcaaaa taaaaaactc    19320

accaaggcca tggcaccgag cgttggtttt cttgtattcc ccttagtatg cggcgcgcgg    19380

cgatgtatga ggaaggtcct cctccctcct acgagagtgt ggtgagcgcg gcgccagtgg    19440

cggcggcgct gggttctccc ttcgatgctc ccctggaccc gccgtttgtg cctccgcggt    19500

acctgcggcc taccgggggg agaaacagca tccgttactc tgagttggca cccctattcg    19560

acaccacccg tgtgtacctg gtggacaaca agtcaacgga tgtggcatcc ctgaactacc    19620

agaacgacca cagcaacttt ctgaccacgg tcattcaaaa caatgactac agcccggggg    19680

aggcaagcac acagaccatc aatcttgacg accggtcgca ctggggcggc gacctgaaaa    19740

ccatcctgca taccaacatg ccaaatgtga acgagttcat gtttaccaat aagtttaagg    19800

cgcgggtgat ggtgtcgcgc ttgcctacta aggacaatca ggtggagctg aaatacgagt    19860

gggtggagtt cacgctgccc gagggcaact actccgagac catgaccata gaccttatga    19920

acaacgcgat cgtggagcac tacttgaaag tgggcagaca gaacggggtt ctggaaagcg    19980

acatcggggt aaagtttgac acccgcaact tcagactggg gtttgacccc gtcactggtc    20040

ttgtcatgcc tggggtatat acaaacgaag ccttccatcc agacatcatt ttgctgccag    20100

gatgcggggt ggacttcacc cacagccgcc tgagcaactt gttgggcatc cgcaagcggc    20160

aacccttcca ggagggcttt aggatcacct acgatgatct ggagggtggt aacattcccg    20220

cactgttgga tgtggacgcc taccaggcga gcttgaaaga tgacaccgaa cagggcgggg    20280

gtggcgcagg cggcagcaac agcagtggca gcggcgcgga agagaactcc aacgcggcag    20340

ccgcggcaat gcagccggtg gaggacatga acgatcatgc cattcgcggc gacacctttg    20400

ccacacgggc tgaggagaag cgcgctgagg ccgaagcagc ggccgaagct gccgcccccg    20460

ctgcgcaacc cgaggtcgag aagcctcaga agaaaccggt gatcaaaccc ctgacagagg    20520

acagcaagaa acgcagttac aacctaataa gcaatgacag caccttcacc cagtaccgca    20580

gctggtacct tgcatacaac tacggcgacc ctcagaccgg aatccgctca tggaccctgc    20640

tttgcactcc tgacgtaacc tgcggctcgg agcaggtcta ctggtcgttg ccagacatga    20700

tgcaagaccc cgtgaccttc cgctccacgc gccagatcag caactttccg gtggtgggcg    20760

ccgagctgtt gcccgtgcac tccaagagct tctacaacga ccaggccgtc tactcccaac    20820

tcatccgcca gtttacctct ctgacccacg tgttcaatcg ctttcccgag aaccagattt    20880

tggcgcgccc gccagccccc accatcacca ccgtcagtga aaacgttcct gctctcacag    20940

atcacgggac gctaccgctg cgcaacagca tcggaggagt ccagcgagtg accattactg    21000

acgccagacg ccgcacctgc ccctacgttt acaaggccct gggcatagtc tcgccgcgcg    21060

tcctatcgag ccgcactttt tgagcaagca tgtccatcct tatatcgccc agcaataaca    21120

caggctgggg cctgcgcttc ccaagcaaga tgtttggcgg ggccaagaag cgctccgacc    21180

aacacccagt gcgcgtgcgc gggcactacc gcgcgccctg gggcgcgcac aaacgcggcc    21240

gcactgggcg caccaccgtc gatgacgcca tcgacgcggt ggtggaggag gcgcgcaact    21300

acacgcccac gccgccacca gtgtccacag tggacgcggc cattcagacc gtggtgcgcg    21360

gagcccggcg ctatgctaaa atgaagagac ggcggaggcg cgtagcacgt cgccaccgcc    21420

gccgacccgg cactgccgcc caacgcgcgg cggcggccct gcttaaccgc gcacgtcgca    21480

ccggccgacg ggcggccatg cgggccgctc gaaggctggc cgcgggtatt gtcactgtgc    21540

cccccaggtc caggcgacga gcggccgccg cagcagccgc ggccattagt gctatgactc    21600

agggtcgcag gggcaacgtg tattgggtgc gcgactcggt tagcggcctg cgcgtgcccg    21660

tgcgcacccg ccccccgcgc aactagattg caagaaaaaa ctacttagac tcgtactgtt    21720

gtatgtatcc agcggcggcg gcgcgcaacg aagctatgtc caagcgcaaa atcaaagaag    21780

agatgctcca ggtcatcgcg ccggagatct atggcccccc gaagaaggaa gagcaggatt    21840

acaagccccg aaagctaaag cgggtcaaaa agaaaaagaa agatgatgat gatgaacttg    21900

acgacgaggt ggaactgctg cacgctaccg cgcccaggcg acgggtacag tggaaaggtc    21960

gacgcgtaaa acgtgttttg cgacccggca ccaccgtagt ctttacgccc ggtgagcgct    22020

ccacccgcac ctacaagcgc gtgtatgatg aggtgtacgg cgacgaggac ctgcttgagc    22080

aggccaacga gcgcctcggg gagtttgcct acggaaagcg gcataaggac atgctggcgt    22140

tgccgctgga cgagggcaac ccaacaccta gcctaaagcc cgtaacactg cagcaggtgc    22200

tgcccgcgct tgcaccgtcc gaagaaaagc gcggcctaaa gcgcgagtct ggtgacttgg    22260

cacccaccgt gcagctgatg gtacccaagc gccagcgact ggaagatgtc ttggaaaaaa    22320

tgaccgtgga acctgggctg gagcccgagg tccgcgtgcg gccaatcaag caggtggcgc    22380

cgggactggg cgtgcagacc gtggacgttc agatacccac taccagtagc accagtattg    22440

ccaccgccac agagggcatg gagacacaaa cgtccccggt tgcctcagcg gtggcggatg    22500

ccgcggtgca ggcggtcgct gcggccgcgt ccaagacctc tacggaggtg caaacggacc    22560

cgtggatgtt tcgcgtttca gccccccggc gcccgcgccg ttcgaggaag tacggcgccg    22620

ccagcgcgct actgcccgaa tatgccctac atccttccat tgcgcctacc cccggctatc    22680

gtggctacac ctaccgcccc agaagacgag caactacccg acgccgaacc accactggaa    22740

cccgccgccg ccgtcgccgt cgccagcccg tgctggcccc gatttccgtg cgcagggtgg    22800

ctcgcgaagg aggcaggacc ctggtgctgc caacagcgcg ctaccacccc agcatcgttt    22860

aaaagccggt ctttgtggtt cttgcagata tggccctcac ctgccgcctc cgtttcccgg    22920

tgccgggatt ccgaggaaga atgcaccgta ggaggggcat ggccggccac ggcctgacgg    22980

gcggcatgcg tcgtgcgcac caccggcggc ggcgcgcgtc gcaccgtcgc atgcgcggcg    23040

gtatcctgcc cctccttatt ccactgatcg ccgcggcgat tggcgccgtg cccggaattg    23100

catccgtggc cttgcaggcg cagagacact gattaaaaac aagttgcatg tggaaaaatc    23160

aaaataaaaa gtctggactc tcacgctcgc ttggtcctgt aactattttg tagaatggaa    23220

gacatcaact ttgcgtctct ggccccgcga cacggctcgc gcccgttcat gggaaactgg    23280

caagatatcg gcaccagcaa tatgagcggt ggcgccttca gctggggctc gctgtggagc    23340

ggcattaaaa atttcggttc caccgttaag aactatggca gcaaggcctg gaacagcagc    23400

acaggccaga tgctgaggga taagttgaaa gagcaaaatt tccaacaaaa ggtggtagat    23460

ggcctggcct ctggcattag cggggtggtg gacctggcca accaggcagt gcaaaataag    23520

attaacagta agcttgatcc ccgccctccc gtagaggagc ctccaccggc cgtggagaca    23580

gtgtctccag aggggcgtgg cgaaaagcgt ccgcgccccg acagggaaga aactctggtg    23640

acgcaaatag acgagcctcc ctcgtacgag gaggcactaa agcaaggcct gcccaccacc    23700

cgtcccatcg cgcccatggc taccggagtg ctgggccagc acacacccgt aacgctggac    23760

ctgcctcccc ccgccgacac ccagcagaaa cctgtgctgc caggcccgac cgccgttgtt    23820

gtaacccgtc ctagccgcgc gtccctgcgc cgcgccgcca gcggtccgcg atcgttgcgg    23880

cccgtagcca gtggcaactg gcaaagcaca ctgaacagca tcgtgggtct gggggtgcaa    23940

tccctgaagc gccgacgatg cttctgatag ctaacgtgtc gtatgtgtgt catgtatgcg    24000

tccatgtcgc cgccagagga gctgctgagc cgccgcgcgc ccgctttcca agatggctac    24060

cccttcgatg atgccgcagt ggtcttacat gcacatctcg ggccaggacg cctcggagta    24120

cctgagcccc gggctggtgc agtttgcccg cgccaccgag acgtacttca gcctgaataa    24180

caagtttaga aaccccacgg tggcgcctac gcacgacgtg accacagacc ggtcccagcg    24240

tttgacgctg cggttcatcc ctgtggaccg tgaggatact gcgtactcgt acaaggcgcg    24300

gttcacccta gctgtgggtg ataaccgtgt gctggacatg gcttccacgt actttgacat    24360

ccgcggcgtg ctggacaggg gccctacttt taagccctac tctggcactg cctacaacgc    24420

cctggctccc aagggtgccc caaatccttg cgaatgggat gaagctgcta ctgctcttga    24480

aataaaccta gaagaagagg acgatgacaa cgaagacgaa gtagacgagc aagctgagca    24540

gcaaaaaact cacgtatttg ggcaggcgcc ttattctggt ataaatatta caaaggaggg    24600

tattcaaata ggtgtcgaag gtcaaacacc taaatatgcc gataaaacat ttcaacctga    24660

acctcaaata ggagaatctc agtggtacga aacagaaatt aatcatgcag ctgggagagt    24720

cctaaaaaag actaccccaa tgaaaccatg ttacggttca tatgcaaaac ccacaaatga    24780

aaatggaggg caaggcattc ttgtaaagca acaaaatgga aagctagaaa gtcaagtgga    24840

aatgcaattt ttctcaacta ctgaggcagc cgcaggcaat ggtgataact tgactcctaa    24900

agtggtattg tacagtgaag atgtagatat agaaacccca gacactcata tttcttacat    24960

gcccactatt aaggaaggta actcacgaga actaatgggc caacaatcta tgcccaacag    25020

gcctaattac attgctttta gggacaattt tattggtcta atgtattaca acagcacggg    25080

taatatgggt gttctggcgg gccaagcatc gcagttgaat gctgttgtag atttgcaaga    25140

cagaaacaca gagctttcat accagctttt gcttgattcc attggtgata gaaccaggta    25200

cttttctatg tggaatcagg ctgttgacag ctatgatcca gatgttagaa ttattgaaaa    25260

tcatggaact gaagatgaac ttccaaatta ctgctttcca ctgggaggtg tgattaatac    25320

agagactctt accaaggtaa aacctaaaac aggtcaggaa aatggatggg aaaaagatgc    25380

tacagaattt tcagataaaa atgaaataag agttggaaat aattttgcca tggaaatcaa    25440

tctaaatgcc aacctgtgga gaaatttcct gtactccaac atagcgctgt atttgcccga    25500

caagctaaag tacagtcctt ccaacgtaaa aatttctgat aacccaaaca cctacgacta    25560

catgaacaag cgagtggtgg ctcccgggct agtggactgc tacattaacc ttggagcacg    25620

ctggtccctt gactatatgg acaacgtcaa cccatttaac caccaccgca atgctggcct    25680

gcgctaccgc tcaatgttgc tgggcaatgg tcgctatgtg cccttccaca tccaggtgcc    25740

tcagaagttc tttgccatta aaaacctcct tctcctgccg ggctcataca cctacgagtg    25800

gaacttcagg aaggatgtta acatggttct gcagagctcc ctaggaaatg acctaagggt    25860

tgacggagcc agcattaagt ttgatagcat ttgcctttac gccaccttct tccccatggc    25920

ccacaacacc gcctccacgc ttgaggccat gcttagaaac gacaccaacg accagtcctt    25980

taacgactat ctctccgccg ccaacatgct ctaccctata cccgccaacg ctaccaacgt    26040

gcccatatcc atcccctccc gcaactgggc ggctttccgc ggctgggcct tcacgcgcct    26100

taagactaag gaaaccccat cactgggctc gggctacgac ccttattaca cctactctgg    26160

ctctataccc tacctagatg gaacctttta cctcaaccac acctttaaga aggtggccat    26220

tacctttgac tcttctgtca gctggcctgg caatgaccgc ctgcttaccc ccaacgagtt    26280

tgaaattaag cgctcagttg acggggaggg ttacaacgtt gcccagtgta acatgaccaa    26340

agactggttc ctggtacaaa tgctagctaa ctataacatt ggctaccagg gcttctatat    26400

cccagagagc tacaaggacc gcatgtactc cttctttaga aacttccagc ccatgagccg    26460

tcaggtggtg gatgatacta aatacaagga ctaccaacag gtgggcatcc tacaccaaca    26520

caacaactct ggatttgttg gctaccttgc ccccaccatg cgcgaaggac aggcctaccc    26580

tgctaacttc ccctatccgc ttataggcaa gaccgcagtt gacagcatta cccagaaaaa    26640

gtttctttgc gatcgcaccc tttggcgcat cccattctcc agtaacttta tgtccatggg    26700

cgcactcaca gacctgggcc aaaaccttct ctacgccaac tccgcccacg cgctagacat    26760

gacttttgag gtggatccca tggacgagcc cacccttctt tatgttttgt ttgaagtctt    26820

tgacgtggtc cgtgtgcacc agccgcaccg cggcgtcatc gaaaccgtgt acctgcgcac    26880

gcccttctcg gccggcaacg ccacaacata aagaagcaag caacatcaac aacagctgcc    26940

gccatgggct ccagtgagca ggaactgaaa gccattgtca aagatcttgg ttgtgggcca    27000

tattttttgg gcacctatga caagcgcttt ccaggctttg tttctccaca caagctcgcc    27060

tgcgccatag tcaatacggc cggtcgcgag actgggggcg tacactggat ggcctttgcc    27120

tggaacccgc actcaaaaac atgctacctc tttgagccct ttggcttttc tgaccagcga    27180

ctcaagcagg tttaccagtt tgagtacgag tcactcctgc gccgtagcgc cattgcttct    27240

tcccccgacc gctgtataac gctggaaaag tccacccaaa gcgtacaggg gcccaactcg    27300

gccgcctgtg gactattctg ctgcatgttt ctccacgcct ttgccaactg gccccaaact    27360

cccatggatc acaaccccac catgaacctt attaccgggg tacccaactc catgctcaac    27420

agtccccagg tacagcccac cctgcgtcgc aaccaggaac agctctacag cttcctggag    27480

cgccactcgc cctacttccg cagccacagt gcgcagatta ggagcgccac ttctttttgt    27540

cacttgaaaa acatgtaaaa ataatgtact agagacactt tcaataaagg caaatgcttt    27600

tatttgtaca ctctcgggtg attatttacc cccacccttg ccgtctgcgc cgtttaaaaa    27660

tcaaaggggt tctgccgcgc atcgctatgc gccactggca gggacacgtt gcgatactgg    27720

tgtttagtgc tccacttaaa ctcaggcaca accatccgcg gcagctcggt gaagttttca    27780

ctccacaggc tgcgcaccat caccaacgcg tttagcaggt cgggcgccga tatcttgaag    27840

tcgcagttgg ggcctccgcc ctgcgcgcgc gagttgcgat acacagggtt gcagcactgg    27900

aacactatca gcgccgggtg gtgcacgctg gccagcacgc tcttgtcgga gatcagatcc    27960

gcgtccaggt cctccgcgtt gctcagggcg aacggagtca actttggtag ctgccttccc    28020

aaaaagggcg cgtgcccagg ctttgagttg cactcgcacc gtagtggcat caaaaggtga    28080

ccgtgcccgg tctgggcgtt aggatacagc gcctgcataa aagccttgat ctgcttaaaa    28140

gccacctgag cctttgcgcc ttcagagaag aacatgccgc aagacttgcc ggaaaactga    28200

ttggccggac aggccgcgtc gtgcacgcag caccttgcgt cggtgttgga gatctgcacc    28260

acatttcggc cccaccggtt cttcacgatc ttggccttgc tagactgctc cttcagcgcg    28320

cgctgcccgt tttcgctcgt cacatccatt tcaatcacgt gctccttatt tatcataatg    28380

cttccgtgta gacacttaag ctcgccttcg atctcagcgc agcggtgcag ccacaacgcg    28440

cagcccgtgg gctcgtgatg cttgtaggtc acctctgcaa acgactgcag gtacgcctgc    28500

aggaatcgcc ccatcatcgt cacaaaggtc ttgttgctgg tgaaggtcag ctgcaacccg    28560

cggtgctcct cgttcagcca ggtcttgcat acggccgcca gagcttccac ttggtcaggc    28620

agtagtttga agttcgcctt tagatcgtta tccacgtggt acttgtccat cagcgcgcgc    28680

gcagcctcca tgcccttctc ccacgcagac acgatcggca cactcagcgg gttcatcacc    28740

gtaatttcac tttccgcttc gctgggctct tcctcttcct cttgcgtccg cataccacgc    28800

gccactgggt cgtcttcatt cagccgccgc actgtgcgct tacctccttt gccatgcttg    28860

attagcaccg gtgggttgct gaaacccacc atttgtagcg ccacatcttc tctttcttcc    28920

tcgctgtcca cgattacctc tggtgatggc gggcgctcgg gcttgggaga agggcgcttc    28980

tttttcttct tgggcgcaat ggccaaatcc gccgccgagg tcgatggccg cgggctgggt    29040

gtgcgcggca ccagcgcgtc ttgtgatgag tcttcctcgt cctcggactc gatacgccgc    29100

ctcatccgct tttttggggg cgcccgggga ggcggcggcg acggggacgg ggacgacacg    29160

tcctccatgg ttgggggacg tcgcgccgca ccgcgtccgc gctcgggggt ggtttcgcgc    29220

tgctcctctt cccgactggc catttccttc tcctataggc agaaaaagat catggagtca    29280

gtcgagaaga aggacagcct aaccgccccc tctgagttcg ccaccaccgc ctccaccgat    29340

gccgccaacg cgcctaccac cttccccgtc gaggcacccc cgcttgagga ggaggaagtg    29400

attatcgagc aggacccagg ttttgtaagc gaagacgacg aggaccgctc agtaccaaca    29460

gaggataaaa agcaagacca ggacaacgca gaggcaaacg aggaacaagt cgggcggggg    29520

gacgaaaggc atggcgacta cctagatgtg ggagacgacg tgctgttgaa gcatctgcag    29580

cgccagtgcg ccattatctg cgacgcgttg caagagcgca gcgatgtgcc cctcgccata    29640

gcggatgtca gccttgccta cgaacgccac ctattctcac cgcgcgtacc ccccaaacgc    29700

caagaaaacg gcacatgcga gcccaacccg cgcctcaact tctaccccgt atttgccgtg    29760

ccagaggtgc ttgccaccta tcacatcttt ttccaaaact gcaagatacc cctatcctgc    29820

cgtgccaacc gcagccgagc ggacaagcag ctggccttgc ggcagggcgc tgtcatacct    29880

gatatcgcct cgctcaacga agtgccaaaa atctttgagg gtcttggacg cgacgagaag    29940

cgcgcggcaa acgctctgca acaggaaaac agcgaaaatg aaagtcactc tggagtgttg    30000

gtggaactcg agggtgacaa cgcgcgccta gccgtactaa aacgcagcat cgaggtcacc    30060

cactttgcct acccggcact taacctaccc cccaaggtca tgagcacagt catgagtgag    30120

ctgatcgtgc gccgtgcgca gcccctggag agggatgcaa atttgcaaga acaaacagag    30180

gagggcctac ccgcagttgg cgacgagcag ctagcgcgct ggcttcaaac gcgcgagcct    30240

gccgacttgg aggagcgacg caaactaatg atggccgcag tgctcgttac cgtggagctt    30300

gagtgcatgc agcggttctt tgctgacccg gagatgcagc gcaagctaga ggaaacattg    30360

cactacacct ttcgacaggg ctacgtacgc caggcctgca agatctccaa cgtggagctc    30420

tgcaacctgg tctcctacct tggaattttg cacgaaaacc gccttgggca aaacgtgctt    30480

cattccacgc tcaagggcga ggcgcgccgc gactacgtcc gcgactgcgt ttacttattt    30540

ctatgctaca cctggcagac ggccatgggc gtttggcagc agtgcttgga ggagtgcaac    30600

ctcaaggagc tgcagaaact gctaaagcaa aacttgaagg acctatggac ggccttcaac    30660

gagcgctccg tggccgcgca cctggcggac atcattttcc ccgaacgcct gcttaaaacc    30720

ctgcaacagg gtctgccaga cttcaccagt caaagcatgt tgcagaactt taggaacttt    30780

atcctagagc gctcaggaat cttgcccgcc acctgctgtg cacttcctag cgactttgtg    30840

cccattaagt accgcgaatg ccctccgccg ctttggggcc actgctacct tctgcagcta    30900

gccaactacc ttgcctacca ctctgacata atggaagacg tgagcggtga cggtctactg    30960

gagtgtcact gtcgctgcaa cctatgcacc ccgcaccgct ccctggtttg caattcgcag    31020

ctgcttaacg aaagtcaaat tatcggtacc tttgagctgc agggtccctc gcctgacgaa    31080

aagtccgcgg ctccggggtt gaaactcact ccggggctgt ggacgtcggc ttaccttcgc    31140

aaatttgtac ctgaggacta ccacgcccac gagattaggt tctacgaaga ccaatcccgc    31200

ccgcctaatg cggagcttac cgcctgcgtc attacccagg gccacattct tggccaattg    31260

caagccatca acaaagcccg ccaagagttt ctgctacgaa agggacgggg ggtttacttg    31320

gacccccagt ccggcgagga gctcaaccca atccccccgc cgccgcagcc ctatcagcag    31380

cagccgcggg cccttgcttc ccaggatggc acccaaaaag aagctgcagc tgccgccgcc    31440

acccacggac gaggaggaat actgggacag tcaggcagag gaggttttgg acgaggagga    31500

ggaggacatg atggaagact gggagagcct agacgaggaa gcttccgagg tcgaagaggt    31560

gtcagacgaa acaccgtcac cctcggtcgc attcccctcg ccggcgcccc agaaatcggc    31620

aaccggttcc agcatggcta caacctccgc tcctcaggcg ccgccggcac tgcccgttcg    31680

ccgacccaac cgtagatggg acaccactgg aaccagggcc ggtaagtcca agcagccgcc    31740

gccgttagcc caagagcaac aacagcgcca aggctaccgc tcatggcgcg ggcacaagaa    31800

cgccatagtt gcttgcttgc aagactgtgg gggcaacatc tccttcgccc gccgctttct    31860

tctctaccat cacggcgtgg ccttcccccg taacatcctg cattactacc gtcatctcta    31920

cagcccatac tgcaccggcg gcagcggcag caacagcagc ggccacacag aagcaaaggc    31980

gaccggatag caagactctg acaaagccca agaaatccac agcggcggca gcagcaggag    32040

gaggagcgct gcgtctggcg cccaacgaac ccgtatcgac ccgcgagctt agaaacagga    32100

tttttcccac tctgtatgct atatttcaac agagcagggg ccaagaacaa gagctgaaaa    32160

taaaaaacag gtctctgcga tccctcaccc gcagctgcct gtatcacaaa agcgaagatc    32220

agcttcggcg cacgctggaa gacgcggagg ctctcttcag taaatactgc gcgctgactc    32280

ttaaggacta gtttcgcgcc ctttctcaaa tttaagcgcg aaaactacgt catctccagc    32340

ggccacaccc ggcgccagca cctgttgtca gcgccattat gagcaaggaa attcccacgc    32400

cctacatgtg gagttaccag ccacaaatgg gacttgcggc tggagctgcc caagactact    32460

caacccgaat aaactacatg agcgcgggac cccacatgat atcccgggtc aacggaatac    32520

gcgcccaccg aaaccgaatt ctcctggaac aggcggctat taccaccaca cctcgtaata    32580

accttaatcc ccgtagttgg cccgctgccc tggtgtacca ggaaagtccc gctcccacca    32640

ctgtggtact tcccagagac gcccaggccg aagttcagat gactaactca ggggcgcagc    32700

ttgcgggcgg ctttcgtcac agggtgcggt cgcccgggca gggtataact cacctgacaa    32760

tcagagggcg aggtattcag ctcaacgacg agtcggtgag ctcctcgctt ggtctccgtc    32820

cggacgggac atttcagatc ggcggcgccg gccgctcttc attcacgcct cgtcaggcaa    32880

tcctaactct gcagacctcg tcctctgagc cgcgctctgg aggcattgga actctgcaat    32940

ttattgagga gtttgtgcca tcggtctact ttaacccctt ctcgggacct cccggccact    33000

atccggatca atttattcct aactttgacg cggtaaagga ctcggcggac ggctacgact    33060

gaatgttaag tggagaggca gagcaactgc gcctgaaaca cctggtccac tgtcgccgcc    33120

acaagtgctt tgcccgcgac tccggtgagt tttgctactt tgaattgccc gaggatcata    33180

tcgagggccc ggcgcacggc gtccggctta ccgcccaggg agagcttgcc cgtagcctga    33240

ttcgggagtt tacccagcgc cccctgctag ttgagcggga caggggaccc tgtgttctca    33300

ctgtgatttg caactgtcct aaccctggat tacatcaaga tcctctagtt aatgtcaggt    33360

cgcctaagtc gattaactag agtacccggg gatcttattc cctttaacta ataaaaaaaa    33420

ataataaagc atcacttact taaaatcagt tagcaaattt ctgtccagtt tattcagcag    33480

cacctccttg ccctcctccc agctctggta ttgcagcttc ctcctggctg caaactttct    33540

ccacaatcta aatggaatgt cagtttcctc ctgttcctgt ccatccgcac ccactatctt    33600

catgttgttg cagatgaagc gcgcaagacc gtctgaagat accttcaacc ccgtgtatcc    33660

atatgacacg gaaaccggtc ctccaactgt gccttttctt actcctccct ttgtatcccc    33720

caatgggttt caagagagtc cccctggggt actctctttg cgcctatccg aacctctagt    33780

tacctccaat ggcatgcttg cgctcaaaat gggcaacggc ctctctctgg acgaggccgg    33840

caaccttacc tcccaaaatg taaccactgt gagcccacct ctcaaaaaaa ccaagtcaaa    33900

cataaacctg gaaatatctg cacccctcac agttacctca gaagccctaa ctgtggctgc    33960

cgccgcacct ctaatggtcg cgggcaacac actcaccatg caatcacagg ccccgctaac    34020

cgtgcacgac tccaaactta gcattgccac ccaaggaccc ctcacagtgt cagaaggaaa    34080

gctagccctg caaacatcag gccccctcac caccaccgat agcagtaccc ttactatcac    34140

tgcctcaccc cctctaacta ctgccactgg tagcttgggc attgacttga aagagcccat    34200

ttatacacaa aatggaaaac taggactaaa gtacggggct cctttgcatg taacagacga    34260

cctaaacact ttgaccgtag caactggtcc aggtgtgact attaataata cttccttgca    34320

aactaaagtt actggagcct tgggttttga ttcacaaggc aatatgcaac ttaatgtagc    34380

aggaggacta aggattgatt ctcaaaacag acgccttata cttgatgtta gttatccgtt    34440

tgatgctcaa aaccaactaa atctaagact aggacagggc cctcttttta taaactcagc    34500

ccacaacttg gatattaact acaacaaagg cctttacttg tttacagctt caaacaattc    34560

caaaaagctt gaggttaacc taagcactgc caaggggttg atgtttgacg ctacagccat    34620

agccattaat gcaggagatg ggcttgaatt tggttcacct aatgcaccaa acacaaatcc    34680

cctcaaaaca aaaattggcc atggcctaga atttgattca aacaaggcta tggttcctaa    34740

actaggaact ggccttagtt ttgacagcac aggtgccatt acagtaggaa acaaaaataa    34800

tgataagcta actttgtgga ccacaccagc tccatctcct aactgtagac taaatgcaga    34860

gaaagatgct aaactcactt tggtcttaac aaaatgtggc agtcaaatac ttgctacagt    34920

ttcagttttg gctgttaaag gcagtttggc tccaatatct ggaacagttc aaagtgctca    34980

tcttattata agatttgacg aaaatggagt gctactaaac aattccttcc tggacccaga    35040

atattggaac tttagaaatg gagatcttac tgaaggcaca gcctatacaa acgctgttgg    35100

atttatgcct aacctatcag cttatccaaa atctcacggt aaaactgcca aaagtaacat    35160

tgtcagtcaa gtttacttaa acggagacaa aactaaacct gtaacactaa ccattacact    35220

aaacggtaca caggaaacag gagacacaac tccaagtgca tactctatgt cattttcatg    35280

ggactggtct ggccacaact acattaatga aatatttgcc acatcctctt acactttttc    35340

atacattgcc caagaataaa gaatcgtttg tgttatgttt caacgtgttt atttttcaat    35400

tgcagaaaat ttcaagtcat ttttcattca gtagtatagc cccaccacca catagcttat    35460

acagatcacc gtaccttaat caaactcaca gaaccctagt attcaacctg ccacctccct    35520

cccaacacac agagtacaca gtcctttctc cccggctggc cttaaaaagc atcatatcat    35580

gggtaacaga catattctta ggtgttatat tccacacggt ttcctgtcga gccaaacgct    35640

catcagtgat attaataaac tccccgggca gctcacttaa gttcatgtcg ctgtccagct    35700

gctgagccac aggctgctgt ccaacttgcg gttgcttaac gggcggcgaa ggagaagtcc    35760

acgcctacat gggggtagag tcataatcgt gcatcaggat agggcggtgg tgctgcagca    35820

gcgcgcgaat aaactgctgc cgccgccgct ccgtcctgca ggaatacaac atggcagtgg    35880

tctcctcagc gatgattcgc accgcccgca gcataaggcg ccttgtcctc cgggcacagc    35940

agcgcaccct gatctcactt aaatcagcac agtaactgca gcacagcacc acaatattgt    36000

tcaaaatccc acagtgcaag gcgctgtatc caaagctcat ggcggggacc acagaaccca    36060

cgtggccatc ataccacaag cgcaggtaga ttaagtggcg acccctcata aacacgctgg    36120

acataaacat tacctctttt ggcatgttgt aattcaccac ctcccggtac catataaacc    36180

tctgattaaa catggcgcca tccaccacca tcctaaacca gctggccaaa acctgcccgc    36240

cggctataca ctgcagggaa ccgggactgg aacaatgaca gtggagagcc caggactcgt    36300

aaccatggat catcatgctc gtcatgatat caatgttggc acaacacagg cacacgtgca    36360

tacacttcct caggattaca agctcctccc gcgttagaac catatcccag ggaacaaccc    36420

attcctgaat cagcgtaaat cccacactgc agggaagacc tcgcacgtaa ctcacgttgt    36480

gcattgtcaa agtgttacat tcgggcagca gcggatgatc ctccagtatg gtagcgcggg    36540

tttctgtctc aaaaggaggt agacgatccc tactgtacgg agtgcgccga gacaaccgag    36600

atcgtgttgg tcgtagtgtc atgccaaatg gaacgccgga cgtagtcata tttcctgaag    36660

caaaaccagg tgcgggcgtg acaaacagat ctgcgtctcc ggtctcgccg cttagatcgc    36720

tctgtgtagt agttgtagta tatccactct ctcaaagcat ccaggcgccc cctggcttcg    36780

ggttctatgt aaactccttc atgcgccgct gccctgataa catccaccac cgcagaataa    36840

gccacaccca gccaacctac acattcgttc tgcgagtcac acacgggagg agcgggaaga    36900

gctggaagaa ccatgttttt ttttttattc caaaagatta tccaaaacct caaaatgaag    36960

atctattaag tgaacgcgct cccctccggt ggcgtggtca aactctacag ccaaagaaca    37020

gataatggca tttgtaagat gttgcacaat ggcttccaaa aggcaaacgg ccctcacgtc    37080

caagtggacg taaaggctaa acccttcagg gtgaatctcc tctataaaca ttccagcacc    37140

ttcaaccatg cccaaataat tctcatctcg ccaccttctc aatatatctc taagcaaatc    37200

ccgaatatta agtccggcca ttgtaaaaat ctgctccaga gcgccctcca ccttcagcct    37260

caagcagcga atcatgattg caaaaattca ggttcctcac agacctgtat aagattcaaa    37320

agcggaacat taacaaaaat accgcgatcc cgtaggtccc ttcgcagggc cagctgaaca    37380

taatcgtgca ggtctgcacg gaccagcgcg gccacttccc cgccaggaac catgacaaaa    37440

gaacccacac tgattatgac acgcatactc ggagctatgc taaccagcgt agccccgatg    37500

taagcttgtt gcatgggcgg cgatataaaa tgcaaggtgc tgctcaaaaa atcaggcaaa    37560

gcctcgcgca aaaaagaaag cacatcgtag tcatgctcat gcagataaag gcaggtaagc    37620

tccggaacca ccacagaaaa agacaccatt tttctctcaa acatgtctgc gggtttctgc    37680

ataaacacaa aataaaataa caaaaaaaca tttaaacatt agaagcctgt cttacaacag    37740

gaaaaacaac ccttataagc ataagacgga ctacggccat gccggcgtga ccgtaaaaaa    37800

actggtcacc gtgattaaaa agcaccaccg acagctcctc ggtcatgtcc ggagtcataa    37860

tgtaagactc ggtaaacaca tcaggttgat tcacatcggt cagtgctaaa aagcgaccga    37920

aatagcccgg gggaatacat acccgcaggc gtagagacaa cattacagcc cccataggag    37980

gtataacaaa attaatagga gagaaaaaca cataaacacc tgaaaaaccc tcctgcctag    38040

gcaaaatagc accctcccgc tccagaacaa catacagcgc ttccacagcg gcagccataa    38100

cagtcagcct taccagtaaa aaagaaaacc tattaaaaaa acaccactcg acacggcacc    38160

agctcaatca gtcacagtgt aaaaaagggc caagtgcaga gcgagtatat ataggactaa    38220

aaaatgacgt aacggttaaa gtccacaaaa aacacccaga aaaccgcacg cgaacctacg    38280

cccagaaacg aaagccaaaa aacccacaac ttcctcaaat cgtcacttcc gttttcccac    38340

gttacgtcac ttcccatttt aagaaaacta caattcccaa cacatacaag ttactccgcc    38400

ctaaaaccta cgtcacccgc cccgttccca cgccccgcgc cacgtcacaa actccacccc    38460

ctcattatca tattggcttc aatccaaaat aaggta                              38496


<210>  225
<211>  9701
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  vector for IgG1 against T27Y H34A H505L ACE2 mutant


<220>
<221>  misc_feature
<222>  (2929)..(2930)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (2934)..(2934)
<223>  n is a, c, g, or t

<400>  225
ggcgtaatct gctgcttgca aacaaaaaaa ccaccgctac cagcggtggt ttgtttgccg       60

gatcaagagc taccaactct ttttccgaag gtaactggct tcagcagagc gcagatacca      120

aatactgtcc ttctagtgta gccgtagtta ggccaccact tcaagaactc tgtagcaccg      180

cctacatacc tcgctctgct gaagccagtt accagtggct gctgccagtg gcgataagtc      240

gtgtcttacc gggttggact caagagatag ttaccggata aggcgcagcg gtcgggctga      300

acggggggtt cgtgcacaca gcccagcttg gagcgaacga cctacaccga actgagatac      360

ctacagcgtg agctatgaga aagcgccacg cttcccgaag ggagaaaggc ggacaggtat      420

ccggtaagcg gcagggtcgg aacaggagag cgcacgaggg agcttccagg gggaaacgcc      480

tggtatcttt atagtcctgt cgggtttcgc cacctctgac ttgagcgtcg atttttgtga      540

tgctcgtcag gggggcggag cctatggaaa aacgccagca acgcaagcta gagtttaaac      600

ttgacagatg agacaataac cctgataaat gcttcaataa tattgaaaaa ggaaaagtat      660

gagtattcaa catttccgtg tcgcccttat tccctttttt gcggcatttt gccttcctgt      720

ttttgctcac ccagaaacgc tggtgaaagt aaaagatgca gaagatcact tgggtgcgcg      780

agtgggttac atcgaactgg atctcaacag cggtaagatc cttgagagtt ttcgccccga      840

agaacgtttc ccaatgatga gcacttttaa agttctgcta tgtggcgcgg tattatcccg      900

tattgatgcc gggcaagagc aactcggtcg ccgcatacac tattctcaga atgacttggt      960

tgaatactca ccagtcacag aaaagcatct tacggatggc atgacagtaa gagaattatg     1020

cagtgctgcc ataaccatga gtgataacac tgcggccaac ttacttctga caactatcgg     1080

aggaccgaag gagctaaccg cttttttgca caacatgggg gatcatgtaa ctcgccttga     1140

tcgttgggaa ccggagctga atgaagccat accaaacgac gagcgtgaca ccacgatgcc     1200

tgtagcaatg gcaacaacgt tgcgaaaact attaactggc gaactactta ctctagcttc     1260

ccggcaacaa ctaatagact ggatggaggc ggataaagtt gcaggaccac ttctgcgctc     1320

ggcacttccg gctggctggt ttattgctga taaatcagga gccggtgagc gtgggtcacg     1380

cggtatcatt gcagcactgg ggccggatgg taagccctcc cgtatcgtag ttatctacac     1440

tacggggagt caggcaacta tggatgaacg aaatagacag atcgctgaga taggtgcctc     1500

actgattaag cattggtaag gataaatttc tggtaaggag gacacgtatg gaagtgggca     1560

agttggggaa gccgtatccg ttgctgaatc tggcatatgt gggagtataa gacgcgcagc     1620

gtcgcatcag gcattttttt ctgcgccaat gcaaaaaggc catccgtcag gatggccttt     1680

cggcataact agggccgccg atatttgaaa atatggcata ttgaaaatgt cgccgatgtg     1740

agtttctgtg taactgatat cgccattttt ccaaaagtga tttttgggca tacgcgatat     1800

ctggcgatag cgcttatatc gtttacgggg gatggcgata gacgactttg gtgacttggg     1860

cgattctgtg tgtcgcaaat atcgcagttt cgatataggt gacagacgat atgaggctat     1920

atcgccgata gaggcgacat caagctggca catggccaat gcatatcgat ctatacattg     1980

aatcaatatt ggccattagc catattattc attggttata tagcataaat caatattggc     2040

tattggccat tgcatacgtt gtatccatat cataatatgt acatttatat tggctcatgt     2100

ccaacattac cgccatgttg acattgatta ttgactagtt attaatagta atcaattacg     2160

gggtcattag ttcatagccc atatatggag ttccgcgtta cataacttac ggtaaatggc     2220

ccgcctggct gaccgcccaa cgacccccgc ccattgacgt caataatgac gtatgttccc     2280

atagtaacgc caatagggac tttccattga cgtcaatggg tggagtattt acggtaaact     2340

gcccacttgg cagtacatca agtgtatcat atgccaagta cgccccctat tgacgtcaat     2400

gacggtaaat ggcccgcctg gcattatgcc cagtacatga ccttatggga ctttcctact     2460

tggcagtaca tctacgtatt agtcatcgct attaccatgg tgatgcggtt ttggcagtac     2520

atcaatgggc gtggatagcg gtttgactca cggggatttc caagtctcca ccccattgac     2580

gtcaatggga gtttgttttg gcaccaaaat caacgggact ttccaaaatg tcgtaacaac     2640

tccgccccat tgacgcaaat gggcggtagg cgtgtacggt gggaggtcta tataagcaga     2700

gctcgtttag tgaaccgtca gatcgcctgg agacgccatc cacgctgttt tgacctccat     2760

agaagacacc gggaccgatc cagcctccgc ggccgggaac ggtgcattgg aacgcggatt     2820

ccccgtgcca agagtgacgt aagtaccgcc tatagagtct ataggcccac ccccttggct     2880

tcttatgcat gctatactgt ttttggcttg gggtctatac accccccgnn ttcntcatgt     2940

tataggtgat ggtatagctt agcctatagg tgtgggttat tgaccattat tgaccactcc     3000

ccctattggt gacgatactt tccattacta atccataaca tggctctttg ccacaactct     3060

ctttattggc tatatgccaa tacactgtcc ttcagagact gacacggact ctgtattttt     3120

acaggatggg gtctcattta ttatttacaa attcacatat acaacaccac cgtccccagt     3180

gcccgcagtt tttattaaac ataacgtggg atctccacgc gaatctcggg tacgtgttcc     3240

ggacatgggc tcttctccgg tagcggcgga gcttctacat ccgagccctg ctcccatgcc     3300

tccagcgact catggtcgct cggcagctcc ttgctcctaa cagtggaggc cagacttagg     3360

cacagcacga tgcccaccac caccagtgtg ccgcacaagg ccgtggcggt agggtatgtg     3420

tctgaaaatg agctcgggga gcgggcttgc accgctgacg catttggaag acttaaggca     3480

gcggcagaag aagatgcagg cagctgagtt gttgtgttct gataagagtc agaggtaact     3540

cccgttgcgg tgctgttaac ggtggagggc agtgtagtct gagcagtact cgttgctgcc     3600

gcgcgcgcca ccagacataa tagctgacag actaacagac tgttcctttc catgggtctt     3660

ttctgcagtc accgtccttg acacgaagct gctagcgcca ccatgagcag cagtagttgg     3720

cttctcttga gtttggtggc agtgacagca gcccagagta ctatcgagga gcaggctaaa     3780

tactttctgg ataagtttaa cgccgaggcc gaagacttgt tctatcaatc ttctctcgct     3840

tcatggaatt acaatactaa catcactgag gagaacgtcc agaatatgaa caatgctggc     3900

gacaaatgga gcgccttctt gaaggagcag tctacccttg cacaaatgta tccactgcag     3960

gagatacaga accttacagt aaagttgcag ctccaggctc tccagcagaa cggatctagc     4020

gtgctttcag aggataaaag caaaaggctg aacaccatac ttaataccat gtccacaatt     4080

tactctactg gtaaagtatg taaccccgac aaccctcaag aatgcctcct tcttgagcca     4140

ggcctcaatg agatcatggc taatagtctg gactataatg aaagactgtg ggcatgggag     4200

tcctggagat ctgaagtagg gaagcaactg aggccccttt atgaagagta cgtcgtactt     4260

aagaatgaaa tggcccgcgc taaccactac gaggattacg gcgattactg gcgtggggac     4320

tatgaagtaa atggtgtaga tggatacgac tatagtcgtg ggcaattgat tgaggatgtg     4380

gagcacactt ttgaggagat aaaaccactc tatgagcatc ttcacgcata tgtgagagct     4440

aaactgatga acgcctaccc aagttacatc agtccaatcg gatgtctccc agctcacctc     4500

cttggcgaca tgtggggacg tttctggacc aatctgtatt ccctcacagt ccctttcggg     4560

caaaagccta atatagacgt gacagacgca atggttgatc aggcttggga tgctcaaagg     4620

atttttaagg aagctgagaa gttttttgtg tcagtcggtt tgccaaatat gacacaaggc     4680

ttctgggaaa atagcatgtt gactgatccc ggtaatgttc aaaaggctgt gtgtcaccct     4740

accgcttggg accttgggaa aggtgacttt cgaatcttga tgtgtaccaa ggtgacaatg     4800

gatgactttc ttacagccca tcatgaaatg ggtcacatcc agtatgatat ggcttatgca     4860

gctcaacctt tcctcttgag aaatggtgca aatgaaggtt ttcatgaagc tgtaggggaa     4920

ataatgtccc tgagtgctgc aaccccaaag catctcaaga gtatcggatt gttgagccca     4980

gattttcaag aagataacga gaccgaaatc aacttccttc tgaaacaagc cctcacaata     5040

gttggtactc ttccattcac atacatgctg gagaaatggc gttggatggt ttttaagggg     5100

gagataccta aagatcagtg gatgaaaaag tggtgggaga tgaagcgtga gatcgtaggg     5160

gtcgtggagc cagtgcctca tgatgagact tactgtgacc cagcatcact cttcctggtt     5220

agcaatgact attcatttat acgttattac actcgcactc tttaccagtt tcaatttcag     5280

gaggctctgt gtcaggctgc caagcatgag ggaccccttc acaagtgtga tattagtaac     5340

agtactgagg caggccaaaa actgttcaat atgttgaggc ttggcaaaag cgagccatgg     5400

actctcgcct tggaaaatgt tgtcggggct aaaaacatga atgtacgccc tctgcttaac     5460

tattttgagc ccctttttac atggctcaag gaccagaata agaactcctt tgtcggctgg     5520

tcaacagact ggtctcccta tgcagacaaa acacatactt gcccaccttg tcctgcacca     5580

gagctgctgg gaggtccaag cgtgttcctg tttccaccca agcccaaaga cacactgatg     5640

atttctcgaa ctccagaagt gacctgcgtg gtcgtggacg tgagccacga ggatcccgaa     5700

gtgaagttca actggtacgt ggatggcgtg gaggtccata atgctaagac taaaccccgg     5760

gaggaacagt acaacagcac ttatagggtc gtgtccgtgc tgaccgtcct gcatcaggat     5820

tggctgaacg ggaaggaata taagtgcaaa gtgtctaata aggcactgcc cgcccctatc     5880

gagaaaacaa ttagcaaggc taagggtcag cctagagaac cacaggtgta cactctgcct     5940

ccaagtcgcg acgagctgac caagaaccag gtgtcactga catgtctggt caaaggcttt     6000

tatccctcag atatcgcagt ggagtgggaa agcaatggac agcctgagaa caattacaag     6060

accacacccc ctgtgctgga cagtgatggc tcattctttc tgtattctaa gctgacagtg     6120

gacaaaagta ggtggcagca gggaaacgtg ttctcctgct ctgtcatgca cgaagcactg     6180

cacaatcatt atacccagaa gagtctgtca ctgagccctg gcaaatgagc gataccgatt     6240

ctagaactag atcataatca gccataccac atttgtagag gttttacttg ctttaaaaaa     6300

cctcccacac ctccccctga acctgaaaca taaaatgaat gcaattgttg ttgttaactt     6360

gtttattgca gcttataatg gttacaaata aagcaatagc atcacaaatt tcacaaataa     6420

agcatttttt tcactgcatt ctagttgtgg tttgtccaaa ctcatcaatg tatcttaagg     6480

ccgcaggtaa gccagcccag gcctcgccct ccagctcaag gcgggacagg tgccctagag     6540

tagcctgcat ccagggacag gccccagccg ggtgctgaca cgtccacctc catctcttcc     6600

tcaggtctgc ccgggtggca tccctgtgac ccctccccag tgcctctcct ggtcgtggaa     6660

ggtgctactc cagtgcccac cagccttgtc ctaataaaat taagttgcat cattttgttt     6720

gactaggtgt ccttgtataa tattatgggg tggaggcggg tggtatggag caaggggccc     6780

aagttaactt gtttattgca gcttataatg gttacaaata aagcaatagc atcacaaatt     6840

tcacaaataa agcatttttt tcactgcatt ctagttgtgg tttgtccaaa ctcatcaatg     6900

tatcttatca tgtctggatc cgcttcaggc accgggcttg cgggtcatgc accaggtgcg     6960

cggtccttcg ggcacctcga cgtcggcggt gacggtgaag ccgagccgct cgtagaaggg     7020

gaggttgcgg ggcgcggagg tctccaggaa ggcgggcacc ccggcgcgct cggccgcctc     7080

cactccgggg agcacgacgg cgctgcccag acccttgccc tggtggtcgg gcgagacgcc     7140

gacggtggcc aggaaccacg cgggctcctt gggccggtgc ggcgccagga ggccttccat     7200

ctgttgctgc gcggccagcc tggaaccgct caactcggcc atgcgcgggc cgatctcggc     7260

gaacaccgcc cccgcttcga cgctctccgg cgtggtccag accgccaccg cggcgccgtc     7320

gtccgcgacc cacaccttgc cgatgtcgag cccgacgcgc gtgaggaaga gttcttgcag     7380

ctcggtgacc cgctcgatgt ggcggtccgg gtcgacggtg tggcgcgtgg cggggtagtc     7440

ggcgaacgcg gcggcgaggg tgcgtacggc ccgggggacg tcgtcgcggg tggcgaggcg     7500

caccgtgggc ttgtactcgg tcatggtggc ctgcagagtc gctctgtgtt cgaggccaca     7560

cgcgtcacct taatatgcga agtggacctg ggaccgcgcc gccccgactg catctgcgtg     7620

ttttcgccaa tgacaagacg ctgggcgggg tttgtgtcat catagaacta aagacatgca     7680

aatatatttc ttccggggac accgccagca aacgcgagca acgggccacg gggatgaagc     7740

agctgcgcca ctccctgaag atccatcgtc tcctaacaag ttacatcact cctgcccttc     7800

ctcaccctca tctccatcac ctccttcatc tccgtcatct ccgtcatcac cctccgcggc     7860

agccccttcc accataggtg gaaaccaggg aggcaaatct actccatcgt caaagctgca     7920

cacagtcacc ctgatattgc aggtaggagc gggctttgtc ataacaaggt ccttaatcgc     7980

atccttcaaa acctcagcaa atatatgagt ttgtaaaaag accatgaaat aacagacaat     8040

ggactccctt agcgggccag gttgtgggcc gggtccaggg gccattccaa aggggagacg     8100

actcaatggt gtaagacgac attgtggaat agcaagggca gttcctcgcc ttaggttgta     8160

aagggaggtc ttactacctc catatacgaa cacaccggcg acccaagttc cttcgtcggt     8220

agtcctttct acgtgactcc tagccaggag agctcttaaa ccttctgcaa tgttctcaaa     8280

tttcgggttg gaacctcctt gaccacgatg ctttccaaac caccctcctt ttttgcgcct     8340

gcctccatca ccctgacccc cgctgcgcgg gggcacgtca ggctcaccat ctgggccgcc     8400

ttcttggtgg tattcaaaat aatcggcttc ccctacaggg tggaaaaatg gccttctacc     8460

tggagggggc ctgcgcggtg gagacccgga tgatgatgac tgactactgg gactcctggg     8520

cctcttttct ccacgtccac gacctctccc cctggctctt tcacgacttc cccccctggc     8580

tctttcacgt cctctacccc ggcggcctcc actacctcct cgaccccggc ctccactacc     8640

tcctcgaccc cggcctccac tgcctcctcg accccggcct ccacctcctg ctcctgcccc     8700

tcccgctcct gctcctgctc ctgttccacc gtgggtccct ttgcagccaa tgcaacttgg     8760

acgtttttgg ggtctccgga caccatctct atgtcttggc cctgatcctg agccgcccgg     8820

ggctcctggt cttccgcctc ctcgtcctcg tcctcttccc cgtcctcgtc catgtgccat     8880

gatggcggcc tgcagctgtg ttcgaggccg cgcgtgtcac cttaatatgc gaagtggacc     8940

tgggaccgcg ccgccccgac tgcatctgcg tgttcgagtt cgccaatgac aagacgctgg     9000

gcggggagat cccccttatt aaccctaaac gggtagcata tgcttcccgg gtagtagtat     9060

atactatcca gactaaccct aattcaatag catatgttac ccaacgggaa gcatatgcta     9120

tcgaattagg gttagtaaaa gggtcctaag gaacagcgat ctggatagca tatgctatcc     9180

taatctatat ctgggtagca tatgctatcc taatctatat ctgggtagca taggctatcc     9240

taatctatat ctgggtagca tatgctatcc taatctatat ctgggtagta tatgctatcc     9300

taatttatat ctgggtagca taggctatcc taatctatat ctgggtagca tatgctatcc     9360

taatctatat ctgggtagta tatgctatcc taatctgtat ccgggtagca tatgctatcc     9420

tcatgcatat acagtcagca tatgataccc agtagtagag tgggagtgct atcctttgca     9480

tatgccgcca cctcccaagg agatctgtcg acatcgatgg gcgcgggtgt acactccgcc     9540

catcccgccc ctaactccgc ccagttccgc ccattctccg cctcatggct gactaatttt     9600

ttttatttat gcagaggccg aggccgcctc ggcctctgag ctattccaga agtagtgagg     9660

aggctttttt ggaggcctag gcttttgcaa aaagctaatt c                         9701


<210>  226
<211>  38496
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  vector for IgA against T27Y H34A H374N ACE2 mutant

<400>  226
tattattgat gatgttaatt aacatgcatg gatcctacgt ctcgaccgat gcccttgaga       60

gccttcaacc cagtcagctc cttccggtgg gcgcggggca tgactatcgt cgccgcactt      120

atgactgtct tctttatcat gcaactcgta ggacaggtgc cggcagcgct ctgggtcatt      180

ttcggcgagg accgctttcg ctggagcgcg acgatgatcg gcctgtcgct tgcggtattc      240

ggaatcttgc acgccctcgc tcaagccttc gtcactggtc ccgccaccaa acgtttcggc      300

gagaagcagg ccattatcgc cggcatggcg gccgacgcgc tgggctacgt cttgctggcg      360

ttcgcgacgc gaggctggat ggccttcccc attatgattc ttctcgcttc cggcggcatc      420

gggatgcccg cgttgcaggc catgctgtcc aggcaggtag atgacgacca tcagggacag      480

cttcaaggat cgctcgcggc tcttaccagc ctaacttcga tcattggacc gctgatcgtc      540

acggcgattt atgccgcctc ggcgagcaca tggaacgggt tggcatggat tgtaggcgcc      600

gccctatacc ttgtctgcct ccccgcgttg cgtcgcggtg catggagccg ggccacctcg      660

acctgaatgg aagccggcgg cacctcgcta acggattcac cactccaaga attggagcca      720

atcaattctt gcggagaact gtgaatgcgc aaaccaaccc ttggcagaac atatccatcg      780

cgtccgccat ctccagcagc cgcacgcggc gcatctcggg cagcgttggg tcctggccac      840

gggtgcgcat gatcgtgctc ctgtcgttga ggacccggct aggctggcgg ggttgcctta      900

ctggttagca gaatgaatca ccgatacgcg agcgaacgtg aagcgactgc tgctgcaaaa      960

cgtctgcgac ctgagcaaca acatgaatgg tcttcggttt ccgtgtttcg taaagtctgg     1020

aaacgcggaa gtcagcgccc tgcaccatta tgttccggat ctgcatcgca ggatgctgct     1080

ggctaccctg tggaacacct acatctgtat taacgaagcg ctggcattga ccctgagtga     1140

tttttctctg gtcccgccgc atccataccg ccagttgttt accctcacaa cgttccagta     1200

accgggcatg ttcatcatca gtaacccgta tcgtgagcat cctctctcgt ttcatcggta     1260

tcattacccc catgaacaga aatccccctt acacggaggc atcagtgacc aaacaggaaa     1320

aaaccgccct taacatggcc cgctttatca gaagccagac attaacgctt ctggagaaac     1380

tcaacgagct ggacgcggat gaacaggcag acatctgtga atcgcttcac gaccacgctg     1440

atgagcttta ccgcagctgc ctcgcgcgtt tcggtgatga cggtgaaaac ctctgacaca     1500

tgcagctccc ggagacggtc acagcttgtc tgtaagcgga tgccgggagc agacaagccc     1560

gtcagggcgc gtcagcgggt gttggcgggt gtcggggcgc agccatgacc cagtcacgta     1620

gcgatagcgg agtgtatact ggcttaacta tgcggcatca gagcagattg tactgagagt     1680

gcaccatatg cggtgtgaaa taccgcacag atgcgtaagg agaaaatacc gcatcaggcg     1740

ctcttccgct tcctcgctca ctgactcgct gcgctcggtc gttcggctgc ggcgagcggt     1800

atcagctcac tcaaaggcgg taatacggtt atccacagaa tcaggggata acgcaggaaa     1860

gaacatgtga gcaaaaggcc agcaaaaggc caggaaccgt aaaaaggccg cgttgctggc     1920

gtttttccat aggctccgcc cccctgacga gcatcacaaa aatcgacgct caagtcagag     1980

gtggcgaaac ccgacaggac tataaagata ccaggcgttt ccccctggaa gctccctcgt     2040

gcgctctcct gttccgaccc tgccgcttac cggatacctg tccgcctttc tcccttcggg     2100

aagcgtggcg ctttctcata gctcacgctg taggtatctc agttcggtgt aggtcgttcg     2160

ctccaagctg ggctgtgtgc acgaaccccc cgttcagccc gaccgctgcg ccttatccgg     2220

taactatcgt cttgagtcca acccggtaag acacgactta tcgccactgg cagcagccac     2280

tggtaacagg attagcagag cgaggtatgt aggcggtgct acagagttct tgaagtggtg     2340

gcctaactac ggctacacta gaaggacagt atttggtatc tgcgctctgc tgaagccagt     2400

taccttcgga aaaagagttg gtagctcttg atccggcaaa caaaccaccg ctggtagcgg     2460

tggttttttt gtttgcaagc agcagattac gcgcagaaaa aaaggatctc aagaagatcc     2520

tttgatcttt tctacggggt ctgacgctca gtggaacgaa aactcacgtt aagggatttt     2580

ggtcatgaga ttatcaaaaa ggatcttcac ctagatcctt ttaaattaaa aatgaagttt     2640

taaatcaatc taaagtatat atgagtaaac ttggtctgac agttaccaat gcttaatcag     2700

tgaggcacct atctcagcga tctgtctatt tcgttcatcc atagttgcct gactccccgt     2760

cgtgtagata actacgatac gggagggctt accatctggc cccagtgctg caatgatacc     2820

gcgagaccca cgctcaccgg ctccagattt atcagcaata aaccagccag ccggaagggc     2880

cgagcgcaga agtggtcctg caactttatc cgcctccatc cagtctatta attgttgccg     2940

ggaagctaga gtaagtagtt cgccagttaa tagtttgcgc aacgttgttg ccattgctgc     3000

agccatgaga ttatcaaaaa ggatcttcac ctagatcctt ttcacgtaga aagccagtcc     3060

gcagaaacgg tgctgacccc ggatgaatgt cagctactgg gctatctgga caagggaaaa     3120

cgcaagcgca aagagaaagc aggtagcttg cagtgggctt acatggcgat agctagactg     3180

ggcggtttta tggacagcaa gcgaaccgga attgccagct ggggcgccct ctggtaaggt     3240

tgggaagccc tgcaaagtaa actggatggc tttcttgccg ccaaggatct gatggcgcag     3300

gggatcaagc tctgatcaag agacaggatg aggatcgttt cgcatgattg aacaagatgg     3360

attgcacgca ggttctccgg ccgcttgggt ggagaggcta ttcggctatg actgggcaca     3420

acagacaatc ggctgctctg atgccgccgt gttccggctg tcagcgcagg ggcgcccggt     3480

tctttttgtc aagaccgacc tgtccggtgc cctgaatgaa ctgcaagacg aggcagcgcg     3540

gctatcgtgg ctggccacga cgggcgttcc ttgcgcagct gtgctcgacg ttgtcactga     3600

agcgggaagg gactggctgc tattgggcga agtgccgggg caggatctcc tgtcatctca     3660

ccttgctcct gccgagaaag tatccatcat ggctgatgca atgcggcggc tgcatacgct     3720

tgatccggct acctgcccat tcgaccacca agcgaaacat cgcatcgagc gagcacgtac     3780

tcggatggaa gccggtcttg tcgatcagga tgatctggac gaagagcatc aggggctcgc     3840

gccagccgaa ctgttcgcca ggctcaaggc gagcatgccc gacggcgagg atctcgtcgt     3900

gacccatggc gatgcctgct tgccgaatat catggtggaa aatggccgct tttctggatt     3960

catcgactgt ggccggctgg gtgtggcgga ccgctatcag gacatagcgt tggctacccg     4020

tgatattgct gaagagcttg gcggcgaatg ggctgaccgc ttcctcgtgc tttacggtat     4080

cgccgctccc gattcgcagc gcatcgcctt ctatcgcctt cttgacgagt tcttctgaat     4140

tttgttaaaa tttttgttaa atcagctcat tttttaacca ataggccgaa atcggcaaaa     4200

tcccttataa atcaaaagaa tagaccgaga tagggttgag tgttgttcca gtttggaaca     4260

agagtccact attaaagaac gtggactcca acgtcaaagg gcgaaaaacc gtctatcagg     4320

gcgatggccc actacgtgaa ccatcaccct aatcaagttt tttggggtcg aggtgccgta     4380

aagcactaaa tcggaaccct aaagggagcc cccgatttag agcttgacgg ggaaagccgg     4440

cgaacgtggc gagaaaggaa gggaagaaag cgaaaggagc gggcgctagg gcgctggcaa     4500

gtgtagcggt cacgctgcgc gtaaccacca cacccgccgc gcttaatgcg ccgctacagg     4560

gcgcgtccat tcgccattca ggatcgaatt aattcttaat taacatcatc aataatatac     4620

cttattttgg attgaagcca atatgataat gagggggtgg agtttgtgac gtggcgcggg     4680

gcgtgggaac ggggcgggtg acgtagtagt gtggcggaag tgtgatgttg caagtgtggc     4740

ggaacacatg taagcgacgg atgtggcaaa agtgacgttt ttggtgtgcg ccggtgtaca     4800

caggaagtga caattttcgc gcggttttag gcggatgttg tagtaaattt gggcgtaacc     4860

gagtaagatt tggccatttt cgcgggaaaa ctgaataaga ggaagtgaaa tctgaataat     4920

tttgtgttac tcatagcgcg taatactgta atagtaatca attacggggt cattagttca     4980

tagcccatat atggagttcc gcgttacata acttacggta aatggcccgc ctggctgacc     5040

gcccaacgac ccccgcccat tgacgtcaat aatgacgtat gttcccatag taacgccaat     5100

agggactttc cattgacgtc aatgggtgga gtatttacgg taaactgccc acttggcagt     5160

acatcaagtg tatcatatgc caagtacgcc ccctattgac gtcaatgacg gtaaatggcc     5220

cgcctggcat tatgcccagt acatgacctt atgggacttt cctacttggc agtacatcta     5280

cgtattagtc atcgctatta ccatggtgat gcggttttgg cagtacatca atgggcgtgg     5340

atagcggttt gactcacggg gatttccaag tctccacccc attgacgtca atgggagttt     5400

gttttggcac caaaatcaac gggactttcc aaaatgtcgt aacaactccg ccccattgac     5460

gcaaatgggc ggtaggcgtg tacggtggga ggtctatata agcagagctg gtttagtgaa     5520

ccgtcagatc cgctagagat ctggtaccgt cgacgcggcc gctcgagcct aagcttatga     5580

gcagcagtag ttggcttctc ttgagtttgg tggcagtgac agcagcccag agtactatcg     5640

aggagcaggc taaatacttt ctggataagt ttaacgccga ggccgaagac ttgttctatc     5700

aatcttctct cgcttcatgg aattacaata ctaacatcac tgaggagaac gtccagaata     5760

tgaacaatgc tggcgacaaa tggagcgcct tcttgaagga gcagtctacc cttgcacaaa     5820

tgtatccact gcaggagata cagaacctta cagtaaagtt gcagctccag gctctccagc     5880

agaacggatc tagcgtgctt tcagaggata aaagcaaaag gctgaacacc atacttaata     5940

ccatgtccac aatttactct actggtaaag tatgtaaccc cgacaaccct caagaatgcc     6000

tccttcttga gccaggcctc aatgagatca tggctaatag tctggactat aatgaaagac     6060

tgtgggcatg ggagtcctgg agatctgaag tagggaagca actgaggccc ctttatgaag     6120

agtacgtcgt acttaagaat gaaatggccc gcgctaacca ctacgaggat tacggcgatt     6180

actggcgtgg ggactatgaa gtaaatggtg tagatggata cgactatagt cgtgggcaat     6240

tgattgagga tgtggagcac acttttgagg agataaaacc actctatgag catcttcacg     6300

catatgtgag agctaaactg atgaacgcct acccaagtta catcagtcca atcggatgtc     6360

tcccagctca cctccttggc gacatgtggg gacgtttctg gaccaatctg tattccctca     6420

cagtcccttt cgggcaaaag cctaatatag acgtgacaga cgcaatggtt gatcaggctt     6480

gggatgctca aaggattttt aaggaagctg agaagttttt tgtgtcagtc ggtttgccaa     6540

atatgacaca aggcttctgg gaaaatagca tgttgactga tcccggtaat gttcaaaagg     6600

ctgtgtgtca ccctaccgct tgggaccttg ggaaaggtga ctttcgaatc ttgatgtgta     6660

ccaaggtgac aatggatgac tttcttacag cccataatga aatgggtcac atccagtatg     6720

atatggctta tgcagctcaa cctttcctct tgagaaatgg tgcaaatgaa ggttttcatg     6780

aagctgtagg ggaaataatg tccctgagtg ctgcaacccc aaagcatctc aagagtatcg     6840

gattgttgag cccagatttt caagaagata acgagaccga aatcaacttc cttctgaaac     6900

aagccctcac aatagttggt actcttccat tcacatacat gctggagaaa tggcgttgga     6960

tggtttttaa gggggagata cctaaagatc agtggatgaa aaagtggtgg gagatgaagc     7020

gtgagatcgt aggggtcgtg gagccagtgc ctcatgatga gacttactgt gacccagcat     7080

cactcttcca cgttagcaat gactattcat ttatacgtta ttacactcgc actctttacc     7140

agtttcaatt tcaggaggct ctgtgtcagg ctgccaagca tgagggaccc cttcacaagt     7200

gtgatattag taacagtact gaggcaggcc aaaaactgtt caatatgttg aggcttggca     7260

aaagcgagcc atggactctc gccttggaaa atgttgtcgg ggctaaaaac atgaatgtac     7320

gccctctgct taactatttt gagccccttt ttacatggct caaggaccag aataagaact     7380

cctttgtcgg ctggtcaaca gactggtctc cctatgcaga ccctagtact cctcctactc     7440

cttctccatc aaccccacca actccatccc ctagctgctg tcacccaagg ctgtctctgc     7500

accgacctgc actcgaagac cttctgttgg gctctgaagc taacctgacc tgtactctta     7560

ctggcttgcg cgatgctagc ggcgtgactt tcacctggac acctagtagc ggtaaaagtg     7620

ctgtacaagg acctcctgaa cgcgacctgt gtggttgcta ctctgtgtct tctgtacttc     7680

ccggctgtgc cgagccctgg aatcacggga aaacctttac ctgcaccgcc gcttaccctg     7740

agtcaaaaac tcccctcact gccacattga gtaagtcagg gaatacattc aggccagagg     7800

ttcatttgtt gcctcctcca tctgaagaac ttgctttgaa cgagctggtc actctgacct     7860

gcttggctag gggtttctcc cccaaagatg tacttgtacg gtggttgcag ggcagccaag     7920

agttgccccg cgaaaagtat ttgacctggg cctcaagaca agaacccagc caggggacta     7980

ccacatttgc cgtgaccagt attctgcgtg tagccgctga agattggaag aaaggggata     8040

cattttcttg catggtaggg catgaggccc ttcccctcgc tttcactcag aagacaatag     8100

acagactcgc cggaaagcct actcacgtga atgttagcgt agtcatggct gaggttgacg     8160

gaacttgcta ctgagatatc cgatccaccg gatctagata actgatcata atcagccata     8220

ccacatttgt agaggtttta cttgctttaa aaaacctccc acacctcccc ctgaacctga     8280

aacataaaat gaatgcaatt gttgttgtta acttgtttat tgcagcttat aatggttaca     8340

aataaagcaa tagcatcaca aatttcacaa ataaagcatt tttttcactg cattctagtt     8400

gtggtttgtc caaactcatc aatgtatctt aggtttagtg aaccgtcaga tccgctagcg     8460

ttacataact tacggtaaat ggcccgcctg gctgaccgcc caacgacccc cgcccattga     8520

cgtcaataat gacgtatgtt cccatagtaa cgccaatagg gactttccat tgacgtcaat     8580

gggtggagta tttacggtaa actgcccact tggcagtaca tcaagtgtat catatgccaa     8640

gtacgccccc tattgacgtc aatgacggta aatggcccgc ctggcattat gcccagtaca     8700

tgaccttatg ggactttcct acttggcagt acatctacgt attagtcatc gctattacca     8760

tggtgatgcg gttttggcag tacatcaatg ggcgtggata gcggtttgac tcacggggat     8820

ttccaagtct ccaccccatt gacgtcaatg ggagtttgtt ttggcaccaa aatcaacggg     8880

actttccaaa atgtcgtaac aactccgccc cattgacgca aatgggcggt aggcgtgtac     8940

ggtgggaggt ctatataagc agagctggtt tagtgaaccg tcagatccgc tagagatctg     9000

gtaccgtcga cgcggccgct cgagcctaag cttatgaaga accatctgct tttctgggga     9060

gtacttgccg ttttcataaa agccgtacat gttaaagcac aagaggacga acgcattgtg     9120

ttggttgata ataaatgcaa atgtgctcgg ataacatctc ggatcattcg tagctcagag     9180

gaccccaatg aggatatagt agagcgaaac atcagaatta tagtacccct gaacaacaga     9240

gagaacataa gtgatcccac aagtccattg cggacacgct ttgtttacca tttgtctgat     9300

ctgtgtaaaa aatgtgatcc aacagaggtg gaactcgaca atcagatcgt caccgccacc     9360

cagtctaaca tctgcgatga agattcagct acagagacat gctacacata cgaccggaac     9420

aagtgctata ctgccgttgt gccactcgtt tacggtggag aaacaaagat ggttgaaact     9480

gcacttacac cagatgcctg ctatccagat tgagatatcc gatccaccgg atctagataa     9540

ctgatcataa tcagccatac cacatttgta gaggttttac ttgctttaaa aaacctccca     9600

cacctccccc tgaacctgaa acataaaatg aatgcaattg ttgttgttaa cttgtttatt     9660

gcagcttata atggttacaa ataaagcaat agcatcacaa atttcacaaa taaagcattt     9720

ttttcactgc attctagttg tggtttgtcc aaactcatca atgtatctta acgcggatct     9780

gggcgtggtt aagggtggga aagaatatat aaggtggggg tcttatgtag ttttgtatct     9840

gttttgcagc agccgccgcc gccatgagca ccaactcgtt tgatggaagc attgtgagct     9900

catatttgac aacgcgcatg cccccatggg ccggggtgcg tcagaatgtg atgggctcca     9960

gcattgatgg tcgccccgtc ctgcccgcaa actctactac cttgacctac gagaccgtgt    10020

ctggaacgcc gttggagact gcagcctccg ccgccgcttc agccgctgca gccaccgccc    10080

gcgggattgt gactgacttt gctttcctga gcccgcttgc aagcagtgca gcttcccgtt    10140

catccgcccg cgatgacaag ttgacggctc ttttggcaca attggattct ttgacccggg    10200

aacttaatgt cgtttctcag cagctgttgg atctgcgcca gcaggtttct gccctgaagg    10260

cttcctcccc tcccaatgcg gtttaaaaca taaataaaaa accagactct gtttggattt    10320

ggatcaagca agtgtcttgc tgtctttatt taggggtttt gcgcgcgcgg taggcccggg    10380

accagcggtc tcggtcgttg agggtcctgt gtattttttc caggacgtgg taaaggtgac    10440

tctggatgtt cagatacatg ggcataagcc cgtctctggg gtggaggtag caccactgca    10500

gagcttcatg ctgcggggtg gtgttgtaga tgatccagtc gtagcaggag cgctgggcgt    10560

ggtgcctaaa aatgtctttc agtagcaagc tgattgccag gggcaggccc ttggtgtaag    10620

tgtttacaaa gcggttaagc tgggatgggt gcatacgtgg ggatatgaga tgcatcttgg    10680

actgtatttt taggttggct atgttcccag ccatatccct ccggggattc atgttgtgca    10740

gaaccaccag cacagtgtat ccggtgcact tgggaaattt gtcatgtagc ttagaaggaa    10800

atgcgtggaa gaacttggag acgcccttgt gacctccaag attttccatg cattcgtcca    10860

taatgatggc aatgggccca cgggcggcgg cctgggcgaa gatatttctg ggatcactaa    10920

cgtcatagtt gtgttccagg atgagatcgt cataggccat ttttacaaag cgcgggcgga    10980

gggtgccaga ctgcggtata atggttccat ccggcccagg ggcgtagtta ccctcacaga    11040

tttgcatttc ccacgctttg agttcagatg gggggatcat gtctacctgc ggggcgatga    11100

agaaaacggt ttccggggta ggggagatca gctgggaaga aagcaggttc ctgagcagct    11160

gcgacttacc gcagccggtg ggcccgtaaa tcacacctat taccggctgc aactggtagt    11220

taagagagct gcagctgccg tcatccctga gcaggggggc cacttcgtta agcatgtccc    11280

tgactcgcat gttttccctg accaaatccg ccagaaggcg ctcgccgccc agcgatagca    11340

gttcttgcaa ggaagcaaag tttttcaacg gtttgagacc gtccgccgta ggcatgcttt    11400

tgagcgtttg accaagcagt tccaggcggt cccacagctc ggtcacctgc tctacggcat    11460

ctcgatccag catatctcct cgtttcgcgg gttggggcgg ctttcgctgt acggcagtag    11520

tcggtgctcg tccagacggg ccagggtcat gtctttccac gggcgcaggg tcctcgtcag    11580

cgtagtctgg gtcacggtga aggggtgcgc tccgggctgc gcgctggcca gggtgcgctt    11640

gaggctggtc ctgctggtgc tgaagcgctg ccggtcttcg ccctgcgcgt cggccaggta    11700

gcatttgacc atggtgtcat agtccagccc ctccgcggcg tggcccttgg cgcgcagctt    11760

gcccttggag gaggcgccgc acgaggggca gtgcagactt ttgagggcgt agagcttggg    11820

cgcgagaaat accgattccg gggagtaggc atccgcgccg caggccccgc agacggtctc    11880

gcattccacg agccaggtga gctctggccg ttcggggtca aaaaccaggt ttcccccatg    11940

ctttttgatg cgtttcttac ctctggtttc catgagccgg tgtccacgct cggtgacgaa    12000

aaggctgtcc gtgtccccgt atacagactt gagaggcctg tcctcgagcg gtgttccgcg    12060

gtcctcctcg tatagaaact cggaccactc tgagacaaag gctcgcgtcc aggccagcac    12120

gaaggaggct aagtgggagg ggtagcggtc gttgtccact agggggtcca ctcgctccag    12180

ggtgtgaaga cacatgtcgc cctcttcggc atcaaggaag gtgattggtt tgtaggtgta    12240

ggccacgtga ccgggtgttc ctgaaggggg gctataaaag ggggtggggg cgcgttcgtc    12300

ctcactctct tccgcatcgc tgtctgcgag ggccagctgt tggggtgagt actccctctg    12360

aaaagcgggc atgacttctg cgctaagatt gtcagtttcc aaaaacgagg aggatttgat    12420

attcacctgg cccgcggtga tgcctttgag ggtggccgca tccatctggt cagaaaagac    12480

aatctttttg ttgtcaagct tggtggcaaa cgacccgtag agggcgttgg acagcaactt    12540

ggcgatggag cgcagggttt ggtttttgtc gcgatcggcg cgctccttgg ccgcgatgtt    12600

tagctgcacg tattcgcgcg caacgcaccg ccattcggga aagacggtgg tgcgctcgtc    12660

gggcaccagg tgcacgcgcc aaccgcggtt gtgcagggtg acaaggtcaa cgctggtggc    12720

tacctctccg cgtaggcgct cgttggtcca gcagaggcgg ccgcccttgc gcgagcagaa    12780

tggcggtagg gggtctagct gcgtctcgtc cggggggtct gcgtccacgg taaagacccc    12840

gggcagcagg cgcgcgtcga agtagtctat cttgcatcct tgcaagtcta gcgcctgctg    12900

ccatgcgcgg gcggcaagcg cgcgctcgta tgggttgagt gggggacccc atggcatggg    12960

gtgggtgagc gcggaggcgt acatgccgca aatgtcgtaa acgtagaggg gctctctgag    13020

tattccaaga tatgtagggt agcatcttcc accgcggatg ctggcgcgca cgtaatcgta    13080

tagttcgtgc gagggagcga ggaggtcggg accgaggttg ctacgggcgg gctgctctgc    13140

tcggaagact atctgcctga agatggcatg tgagttggat gatatggttg gacgctggaa    13200

gacgttgaag ctggcgtctg tgagacctac cgcgtcacgc acgaaggagg cgtaggagtc    13260

gcgcagcttg ttgaccagct cggcggtgac ctgcacgtct agggcgcagt agtccagggt    13320

ttccttgatg atgtcatact tatcctgtcc cttttttttc cacagctcgc ggttgaggac    13380

aaactcttcg cggtctttcc agtactcttg gatcggaaac ccgtcggcct ccgaacggta    13440

agagcctagc atgtagaact ggttgacggc ctggtaggcg cagcatccct tttctacggg    13500

tagcgcgtat gcctgcgcgg ccttccggca tgaccagcat gaagggcacg agctgcttcc    13560

caaaggcccc catccaagta taggtctcta catcgtaggt gacaaagaga cgctcggtgc    13620

gaggatgcga gccgatcggg aagaactgga tctcccgcca ccaattggag gagtggctat    13680

tgatgtggtg aaagtagaag tccctgcgac gggccgaaca ctcgtgctgg cttttgtaaa    13740

aacgtgcgca gtactggcag cggtgcacgg gctgtacatc ctgcacgagg ttgacctgac    13800

gaccgcgcac aaggaagcag agtgggaatt tgagcccctc gcctggcggg tttggctggt    13860

ggtcttctac ttcggctgct tgtccttgac cgtctggctg ctcgagggga gttacggtgg    13920

atcggaccac cacgccgcgc gagcccaaag tccagatgtc cgcgcgcggc ggtcggagct    13980

tgatgacaac atcgcgcaga tgggagctgt ccatggtctg gagctcccgc ggcgtcaggt    14040

caggcgggag ctcctgcagg tttacctcgc atagacgggt cagggcgcgg gctagatcca    14100

ggtgatacct aatttccagg ggctggttgg tggcggcgtc gatggcttgc aagaggccgc    14160

atccccgcgg cgcgactacg gtaccgcgcg gcgggcggtg ggccgcgggg gtgtccttgg    14220

atgatgcatc taaaagcggt gacgcgggcg agcccccgga ggtagggggg gctccggacc    14280

cgccgggaga gggggcaggg gcacgtcggc gccgcgcgcg ggcaggagct ggtgctgcgc    14340

gcgtaggttg ctggcgaacg cgacgacgcg gcggttgatc tcctgaatct ggcgcctctg    14400

cgtgaagacg acgggcccgg tgagcttgaa cctgaaagag agttcgacag aatcaatttc    14460

ggtgtcgttg acggcggcct ggcgcaaaat ctcctgcacg tctcctgagt tgtcttgata    14520

ggcgatctcg gccatgaact gctcgatctc ttcctcctgg agatctccgc gtccggctcg    14580

ctccacggtg gcggcgaggt cgttggaaat gcgggccatg agctgcgaga aggcgttgag    14640

gcctccctcg ttccagacgc ggctgtagac cacgccccct tcggcatcgc gggcgcgcat    14700

gaccacctgc gcgagattga gctccacgtg ccgggcgaag acggcgtagt ttcgcaggcg    14760

ctgaaagagg tagttgaggg tggtggcggt gtgttctgcc acgaagaagt acataaccca    14820

gcgtcgcaac gtggattcgt tgataattgt tgtgtaggta ctccgccgcc gagggacctg    14880

agcgagtccg catcgaccgg atcggaaaac ctctcgagaa aggcgtctaa ccagtcacag    14940

tcgcaaggta ggctgagcac cgtggcgggc ggcagcgggc ggcggtcggg gttgtttctg    15000

gcggaggtgc tgctgatgat gtaattaaag taggcggtct tgagacggcg gatggtcgac    15060

agaagcacca tgtccttggg tccggcctgc tgaatgcgca ggcggtcggc catgccccag    15120

gcttcgtttt gacatcggcg caggtctttg tagtagtctt gcatgagcct ttctaccggc    15180

acttcttctt ctccttcctc ttgtcctgca tctcttgcat ctatcgctgc ggcggcggcg    15240

gagtttggcc gtaggtggcg ccctcttcct cccatgcgtg tgaccccgaa gcccctcatc    15300

ggctgaagca gggctaggtc ggcgacaacg cgctcggcta atatggcctg ctgcacctgc    15360

gtgagggtag actggaagtc atccatgtcc acaaagcggt ggtatgcgcc cgtgttgatg    15420

gtgtaagtgc agttggccat aacggaccag ttaacggtct ggtgacccgg ctgcgagagc    15480

tcggtgtacc tgagacgcga gtaagccctc gagtcaaata cgtagtcgtt gcaagtccgc    15540

accaggtact ggtatcccac caaaaagtgc ggcggcggct ggcggtagag gggccagcgt    15600

agggtggccg gggctccggg ggcgagatct tccaacataa ggcgatgata tccgtagatg    15660

tacctggaca tccaggtgat gccggcggcg gtggtggagg cgcgcggaaa gtcgcggacg    15720

cggttccaga tgttgcgcag cggcaaaaag tgctccatgg tcgggacgct ctggccggtc    15780

aggcgcgcgc aatcgttgac gctctagcgt gcaaaaggag agcctgtaag cgggcactct    15840

tccgtggtct ggtggataaa ttcgcaaggg tatcatggcg gacgaccggg gttcgagccc    15900

cgtatccggc cgtccgccgt gatccatgcg gttaccgccc gcgtgtcgaa cccaggtgtg    15960

cgacgtcaga caacggggga gtgctccttt tggcttcctt ccaggcgcgg cggctgctgc    16020

gctagctttt ttggccactg gccgcgcgca gcgtaagcgg ttaggctgga aagcgaaagc    16080

attaagtggc tcgctccctg tagccggagg gttattttcc aagggttgag tcgcgggacc    16140

cccggttcga gtctcggacc ggccggactg cggcgaacgg gggtttgcct ccccgtcatg    16200

caagaccccg cttgcaaatt cctccggaaa cagggacgag cccctttttt gcttttccca    16260

gatgcatccg gtgctgcggc agatgcgccc ccctcctcag cagcggcaag agcaagagca    16320

gcggcagaca tgcagggcac cctcccctcc tcctaccgcg tcaggagggg cgacatccgc    16380

ggttgacgcg gcagcagatg gtgattacga acccccgcgg cgccgggccc ggcactacct    16440

ggacttggag gagggcgagg gcctggcgcg gctaggagcg ccctctcctg agcggcaccc    16500

aagggtgcag ctgaagcgtg atacgcgtga ggcgtacgtg ccgcggcaga acctgtttcg    16560

cgaccgcgag ggagaggagc ccgaggagat gcgggatcga aagttccacg cagggcgcga    16620

gctgcggcat ggcctgaatc gcgagcggtt gctgcgcgag gaggactttg agcccgacgc    16680

gcgaaccggg attagtcccg cgcgcgcaca cgtggcggcc gccgacctgg taaccgcata    16740

cgagcagacg gtgaaccagg agattaactt tcaaaaaagc tttaacaacc acgtgcgtac    16800

gcttgtggcg cgcgaggagg tggctatagg actgatgcat ctgtgggact ttgtaagcgc    16860

gctggagcaa aacccaaata gcaagccgct catggcgcag ctgttcctta tagtgcagca    16920

cagcagggac aacgaggcat tcagggatgc gctgctaaac atagtagagc ccgagggccg    16980

ctggctgctc gatttgataa acatcctgca gagcatagtg gtgcaggagc gcagcttgag    17040

cctggctgac aaggtggccg ccatcaacta ttccatgctt agcctgggca agttttacgc    17100

ccgcaagata taccataccc cttacgttcc catagacaag gaggtaaaga tcgaggggtt    17160

ctacatgcgc atggcgctga aggtgcttac cttgagcgac gacctgggcg tttatcgcaa    17220

cgagcgcatc cacaaggccg tgagcgtgag ccggcggcgc gagctcagcg accgcgagct    17280

gatgcacagc ctgcaaaggg ccctggctgg cacgggcagc ggcgatagag aggccgagtc    17340

ctactttgac gcgggcgctg acctgcgctg ggccccaagc cgacgcgccc tggaggcagc    17400

tggggccgga cctgggctgg cggtggcacc cgcgcgcgct ggcaacgtcg gcggcgtgga    17460

ggaatatgac gaggacgatg agtacgagcc agaggacggc gagtactaag cggtgatgtt    17520

tctgatcaga tgatgcaaga cgcaacggac ccggcggtgc gggcggcgct gcagagccag    17580

ccgtccggcc ttaactccac ggacgactgg cgccaggtca tggaccgcat catgtcgctg    17640

actgcgcgca atcctgacgc gttccggcag cagccgcagg ccaaccggct ctccgcaatt    17700

ctggaagcgg tggtcccggc gcgcgcaaac cccacgcacg agaaggtgct ggcgatcgta    17760

aacgcgctgg ccgaaaacag ggccatccgg cccgacgagg ccggcctggt ctacgacgcg    17820

ctgcttcagc gcgtggctcg ttacaacagc ggcaacgtgc agaccaacct ggaccggctg    17880

gtgggggatg tgcgcgaggc cgtggcgcag cgtgagcgcg cgcagcagca gggcaacctg    17940

ggctccatgg ttgcactaaa cgccttcctg agtacacagc ccgccaacgt gccgcgggga    18000

caggaggact acaccaactt tgtgagcgca ctgcggctaa tggtgactga gacaccgcaa    18060

agtgaggtgt accagtctgg gccagactat tttttccaga ccagtagaca aggcctgcag    18120

accgtaaacc tgagccaggc tttcaaaaac ttgcaggggc tgtggggggt gcgggctccc    18180

acaggcgacc gcgcgaccgt gtctagcttg ctgacgccca actcgcgcct gttgctgctg    18240

ctaatagcgc ccttcacgga cagtggcagc gtgtcccggg acacatacct aggtcacttg    18300

ctgacactgt accgcgaggc cataggtcag gcgcatgtgg acgagcatac tttccaggag    18360

attacaagtg tcagccgcgc gctggggcag gaggacacgg gcagcctgga ggcaacccta    18420

aactacctgc tgaccaaccg gcggcagaag atcccctcgt tgcacagttt aaacagcgag    18480

gaggagcgca ttttgcgcta cgtgcagcag agcgtgagcc ttaacctgat gcgcgacggg    18540

gtaacgccca gcgtggcgct ggacatgacc gcgcgcaaca tggaaccggg catgtatgcc    18600

tcaaaccggc cgtttatcaa ccgcctaatg gactacttgc atcgcgcggc cgccgtgaac    18660

cccgagtatt tcaccaatgc catcttgaac ccgcactggc taccgccccc tggtttctac    18720

accgggggat tcgaggtgcc cgagggtaac gatggattcc tctgggacga catagacgac    18780

agcgtgtttt ccccgcaacc gcagaccctg ctagagttgc aacagcgcga gcaggcagag    18840

gcggcgctgc gaaaggaaag cttccgcagg ccaagcagct tgtccgatct aggcgctgcg    18900

gccccgcggt cagatgctag tagcccattt ccaagcttga tagggtctct taccagcact    18960

cgcaccaccc gcccgcgcct gctgggcgag gaggagtacc taaacaactc gctgctgcag    19020

ccgcagcgcg aaaaaaacct gcctccggca tttcccaaca acgggataga gagcctagtg    19080

gacaagatga gtagatggaa gacgtacgcg caggagcaca gggacgtgcc aggcccgcgc    19140

ccgcccaccc gtcgtcaaag gcacgaccgt cagcggggtc tggtgtggga ggacgatgac    19200

tcggcagacg acagcagcgt cctggatttg ggagggagtg gcaacccgtt tgcgcacctt    19260

cgccccaggc tggggagaat gttttaaaaa aaaaaaagca tgatgcaaaa taaaaaactc    19320

accaaggcca tggcaccgag cgttggtttt cttgtattcc ccttagtatg cggcgcgcgg    19380

cgatgtatga ggaaggtcct cctccctcct acgagagtgt ggtgagcgcg gcgccagtgg    19440

cggcggcgct gggttctccc ttcgatgctc ccctggaccc gccgtttgtg cctccgcggt    19500

acctgcggcc taccgggggg agaaacagca tccgttactc tgagttggca cccctattcg    19560

acaccacccg tgtgtacctg gtggacaaca agtcaacgga tgtggcatcc ctgaactacc    19620

agaacgacca cagcaacttt ctgaccacgg tcattcaaaa caatgactac agcccggggg    19680

aggcaagcac acagaccatc aatcttgacg accggtcgca ctggggcggc gacctgaaaa    19740

ccatcctgca taccaacatg ccaaatgtga acgagttcat gtttaccaat aagtttaagg    19800

cgcgggtgat ggtgtcgcgc ttgcctacta aggacaatca ggtggagctg aaatacgagt    19860

gggtggagtt cacgctgccc gagggcaact actccgagac catgaccata gaccttatga    19920

acaacgcgat cgtggagcac tacttgaaag tgggcagaca gaacggggtt ctggaaagcg    19980

acatcggggt aaagtttgac acccgcaact tcagactggg gtttgacccc gtcactggtc    20040

ttgtcatgcc tggggtatat acaaacgaag ccttccatcc agacatcatt ttgctgccag    20100

gatgcggggt ggacttcacc cacagccgcc tgagcaactt gttgggcatc cgcaagcggc    20160

aacccttcca ggagggcttt aggatcacct acgatgatct ggagggtggt aacattcccg    20220

cactgttgga tgtggacgcc taccaggcga gcttgaaaga tgacaccgaa cagggcgggg    20280

gtggcgcagg cggcagcaac agcagtggca gcggcgcgga agagaactcc aacgcggcag    20340

ccgcggcaat gcagccggtg gaggacatga acgatcatgc cattcgcggc gacacctttg    20400

ccacacgggc tgaggagaag cgcgctgagg ccgaagcagc ggccgaagct gccgcccccg    20460

ctgcgcaacc cgaggtcgag aagcctcaga agaaaccggt gatcaaaccc ctgacagagg    20520

acagcaagaa acgcagttac aacctaataa gcaatgacag caccttcacc cagtaccgca    20580

gctggtacct tgcatacaac tacggcgacc ctcagaccgg aatccgctca tggaccctgc    20640

tttgcactcc tgacgtaacc tgcggctcgg agcaggtcta ctggtcgttg ccagacatga    20700

tgcaagaccc cgtgaccttc cgctccacgc gccagatcag caactttccg gtggtgggcg    20760

ccgagctgtt gcccgtgcac tccaagagct tctacaacga ccaggccgtc tactcccaac    20820

tcatccgcca gtttacctct ctgacccacg tgttcaatcg ctttcccgag aaccagattt    20880

tggcgcgccc gccagccccc accatcacca ccgtcagtga aaacgttcct gctctcacag    20940

atcacgggac gctaccgctg cgcaacagca tcggaggagt ccagcgagtg accattactg    21000

acgccagacg ccgcacctgc ccctacgttt acaaggccct gggcatagtc tcgccgcgcg    21060

tcctatcgag ccgcactttt tgagcaagca tgtccatcct tatatcgccc agcaataaca    21120

caggctgggg cctgcgcttc ccaagcaaga tgtttggcgg ggccaagaag cgctccgacc    21180

aacacccagt gcgcgtgcgc gggcactacc gcgcgccctg gggcgcgcac aaacgcggcc    21240

gcactgggcg caccaccgtc gatgacgcca tcgacgcggt ggtggaggag gcgcgcaact    21300

acacgcccac gccgccacca gtgtccacag tggacgcggc cattcagacc gtggtgcgcg    21360

gagcccggcg ctatgctaaa atgaagagac ggcggaggcg cgtagcacgt cgccaccgcc    21420

gccgacccgg cactgccgcc caacgcgcgg cggcggccct gcttaaccgc gcacgtcgca    21480

ccggccgacg ggcggccatg cgggccgctc gaaggctggc cgcgggtatt gtcactgtgc    21540

cccccaggtc caggcgacga gcggccgccg cagcagccgc ggccattagt gctatgactc    21600

agggtcgcag gggcaacgtg tattgggtgc gcgactcggt tagcggcctg cgcgtgcccg    21660

tgcgcacccg ccccccgcgc aactagattg caagaaaaaa ctacttagac tcgtactgtt    21720

gtatgtatcc agcggcggcg gcgcgcaacg aagctatgtc caagcgcaaa atcaaagaag    21780

agatgctcca ggtcatcgcg ccggagatct atggcccccc gaagaaggaa gagcaggatt    21840

acaagccccg aaagctaaag cgggtcaaaa agaaaaagaa agatgatgat gatgaacttg    21900

acgacgaggt ggaactgctg cacgctaccg cgcccaggcg acgggtacag tggaaaggtc    21960

gacgcgtaaa acgtgttttg cgacccggca ccaccgtagt ctttacgccc ggtgagcgct    22020

ccacccgcac ctacaagcgc gtgtatgatg aggtgtacgg cgacgaggac ctgcttgagc    22080

aggccaacga gcgcctcggg gagtttgcct acggaaagcg gcataaggac atgctggcgt    22140

tgccgctgga cgagggcaac ccaacaccta gcctaaagcc cgtaacactg cagcaggtgc    22200

tgcccgcgct tgcaccgtcc gaagaaaagc gcggcctaaa gcgcgagtct ggtgacttgg    22260

cacccaccgt gcagctgatg gtacccaagc gccagcgact ggaagatgtc ttggaaaaaa    22320

tgaccgtgga acctgggctg gagcccgagg tccgcgtgcg gccaatcaag caggtggcgc    22380

cgggactggg cgtgcagacc gtggacgttc agatacccac taccagtagc accagtattg    22440

ccaccgccac agagggcatg gagacacaaa cgtccccggt tgcctcagcg gtggcggatg    22500

ccgcggtgca ggcggtcgct gcggccgcgt ccaagacctc tacggaggtg caaacggacc    22560

cgtggatgtt tcgcgtttca gccccccggc gcccgcgccg ttcgaggaag tacggcgccg    22620

ccagcgcgct actgcccgaa tatgccctac atccttccat tgcgcctacc cccggctatc    22680

gtggctacac ctaccgcccc agaagacgag caactacccg acgccgaacc accactggaa    22740

cccgccgccg ccgtcgccgt cgccagcccg tgctggcccc gatttccgtg cgcagggtgg    22800

ctcgcgaagg aggcaggacc ctggtgctgc caacagcgcg ctaccacccc agcatcgttt    22860

aaaagccggt ctttgtggtt cttgcagata tggccctcac ctgccgcctc cgtttcccgg    22920

tgccgggatt ccgaggaaga atgcaccgta ggaggggcat ggccggccac ggcctgacgg    22980

gcggcatgcg tcgtgcgcac caccggcggc ggcgcgcgtc gcaccgtcgc atgcgcggcg    23040

gtatcctgcc cctccttatt ccactgatcg ccgcggcgat tggcgccgtg cccggaattg    23100

catccgtggc cttgcaggcg cagagacact gattaaaaac aagttgcatg tggaaaaatc    23160

aaaataaaaa gtctggactc tcacgctcgc ttggtcctgt aactattttg tagaatggaa    23220

gacatcaact ttgcgtctct ggccccgcga cacggctcgc gcccgttcat gggaaactgg    23280

caagatatcg gcaccagcaa tatgagcggt ggcgccttca gctggggctc gctgtggagc    23340

ggcattaaaa atttcggttc caccgttaag aactatggca gcaaggcctg gaacagcagc    23400

acaggccaga tgctgaggga taagttgaaa gagcaaaatt tccaacaaaa ggtggtagat    23460

ggcctggcct ctggcattag cggggtggtg gacctggcca accaggcagt gcaaaataag    23520

attaacagta agcttgatcc ccgccctccc gtagaggagc ctccaccggc cgtggagaca    23580

gtgtctccag aggggcgtgg cgaaaagcgt ccgcgccccg acagggaaga aactctggtg    23640

acgcaaatag acgagcctcc ctcgtacgag gaggcactaa agcaaggcct gcccaccacc    23700

cgtcccatcg cgcccatggc taccggagtg ctgggccagc acacacccgt aacgctggac    23760

ctgcctcccc ccgccgacac ccagcagaaa cctgtgctgc caggcccgac cgccgttgtt    23820

gtaacccgtc ctagccgcgc gtccctgcgc cgcgccgcca gcggtccgcg atcgttgcgg    23880

cccgtagcca gtggcaactg gcaaagcaca ctgaacagca tcgtgggtct gggggtgcaa    23940

tccctgaagc gccgacgatg cttctgatag ctaacgtgtc gtatgtgtgt catgtatgcg    24000

tccatgtcgc cgccagagga gctgctgagc cgccgcgcgc ccgctttcca agatggctac    24060

cccttcgatg atgccgcagt ggtcttacat gcacatctcg ggccaggacg cctcggagta    24120

cctgagcccc gggctggtgc agtttgcccg cgccaccgag acgtacttca gcctgaataa    24180

caagtttaga aaccccacgg tggcgcctac gcacgacgtg accacagacc ggtcccagcg    24240

tttgacgctg cggttcatcc ctgtggaccg tgaggatact gcgtactcgt acaaggcgcg    24300

gttcacccta gctgtgggtg ataaccgtgt gctggacatg gcttccacgt actttgacat    24360

ccgcggcgtg ctggacaggg gccctacttt taagccctac tctggcactg cctacaacgc    24420

cctggctccc aagggtgccc caaatccttg cgaatgggat gaagctgcta ctgctcttga    24480

aataaaccta gaagaagagg acgatgacaa cgaagacgaa gtagacgagc aagctgagca    24540

gcaaaaaact cacgtatttg ggcaggcgcc ttattctggt ataaatatta caaaggaggg    24600

tattcaaata ggtgtcgaag gtcaaacacc taaatatgcc gataaaacat ttcaacctga    24660

acctcaaata ggagaatctc agtggtacga aacagaaatt aatcatgcag ctgggagagt    24720

cctaaaaaag actaccccaa tgaaaccatg ttacggttca tatgcaaaac ccacaaatga    24780

aaatggaggg caaggcattc ttgtaaagca acaaaatgga aagctagaaa gtcaagtgga    24840

aatgcaattt ttctcaacta ctgaggcagc cgcaggcaat ggtgataact tgactcctaa    24900

agtggtattg tacagtgaag atgtagatat agaaacccca gacactcata tttcttacat    24960

gcccactatt aaggaaggta actcacgaga actaatgggc caacaatcta tgcccaacag    25020

gcctaattac attgctttta gggacaattt tattggtcta atgtattaca acagcacggg    25080

taatatgggt gttctggcgg gccaagcatc gcagttgaat gctgttgtag atttgcaaga    25140

cagaaacaca gagctttcat accagctttt gcttgattcc attggtgata gaaccaggta    25200

cttttctatg tggaatcagg ctgttgacag ctatgatcca gatgttagaa ttattgaaaa    25260

tcatggaact gaagatgaac ttccaaatta ctgctttcca ctgggaggtg tgattaatac    25320

agagactctt accaaggtaa aacctaaaac aggtcaggaa aatggatggg aaaaagatgc    25380

tacagaattt tcagataaaa atgaaataag agttggaaat aattttgcca tggaaatcaa    25440

tctaaatgcc aacctgtgga gaaatttcct gtactccaac atagcgctgt atttgcccga    25500

caagctaaag tacagtcctt ccaacgtaaa aatttctgat aacccaaaca cctacgacta    25560

catgaacaag cgagtggtgg ctcccgggct agtggactgc tacattaacc ttggagcacg    25620

ctggtccctt gactatatgg acaacgtcaa cccatttaac caccaccgca atgctggcct    25680

gcgctaccgc tcaatgttgc tgggcaatgg tcgctatgtg cccttccaca tccaggtgcc    25740

tcagaagttc tttgccatta aaaacctcct tctcctgccg ggctcataca cctacgagtg    25800

gaacttcagg aaggatgtta acatggttct gcagagctcc ctaggaaatg acctaagggt    25860

tgacggagcc agcattaagt ttgatagcat ttgcctttac gccaccttct tccccatggc    25920

ccacaacacc gcctccacgc ttgaggccat gcttagaaac gacaccaacg accagtcctt    25980

taacgactat ctctccgccg ccaacatgct ctaccctata cccgccaacg ctaccaacgt    26040

gcccatatcc atcccctccc gcaactgggc ggctttccgc ggctgggcct tcacgcgcct    26100

taagactaag gaaaccccat cactgggctc gggctacgac ccttattaca cctactctgg    26160

ctctataccc tacctagatg gaacctttta cctcaaccac acctttaaga aggtggccat    26220

tacctttgac tcttctgtca gctggcctgg caatgaccgc ctgcttaccc ccaacgagtt    26280

tgaaattaag cgctcagttg acggggaggg ttacaacgtt gcccagtgta acatgaccaa    26340

agactggttc ctggtacaaa tgctagctaa ctataacatt ggctaccagg gcttctatat    26400

cccagagagc tacaaggacc gcatgtactc cttctttaga aacttccagc ccatgagccg    26460

tcaggtggtg gatgatacta aatacaagga ctaccaacag gtgggcatcc tacaccaaca    26520

caacaactct ggatttgttg gctaccttgc ccccaccatg cgcgaaggac aggcctaccc    26580

tgctaacttc ccctatccgc ttataggcaa gaccgcagtt gacagcatta cccagaaaaa    26640

gtttctttgc gatcgcaccc tttggcgcat cccattctcc agtaacttta tgtccatggg    26700

cgcactcaca gacctgggcc aaaaccttct ctacgccaac tccgcccacg cgctagacat    26760

gacttttgag gtggatccca tggacgagcc cacccttctt tatgttttgt ttgaagtctt    26820

tgacgtggtc cgtgtgcacc agccgcaccg cggcgtcatc gaaaccgtgt acctgcgcac    26880

gcccttctcg gccggcaacg ccacaacata aagaagcaag caacatcaac aacagctgcc    26940

gccatgggct ccagtgagca ggaactgaaa gccattgtca aagatcttgg ttgtgggcca    27000

tattttttgg gcacctatga caagcgcttt ccaggctttg tttctccaca caagctcgcc    27060

tgcgccatag tcaatacggc cggtcgcgag actgggggcg tacactggat ggcctttgcc    27120

tggaacccgc actcaaaaac atgctacctc tttgagccct ttggcttttc tgaccagcga    27180

ctcaagcagg tttaccagtt tgagtacgag tcactcctgc gccgtagcgc cattgcttct    27240

tcccccgacc gctgtataac gctggaaaag tccacccaaa gcgtacaggg gcccaactcg    27300

gccgcctgtg gactattctg ctgcatgttt ctccacgcct ttgccaactg gccccaaact    27360

cccatggatc acaaccccac catgaacctt attaccgggg tacccaactc catgctcaac    27420

agtccccagg tacagcccac cctgcgtcgc aaccaggaac agctctacag cttcctggag    27480

cgccactcgc cctacttccg cagccacagt gcgcagatta ggagcgccac ttctttttgt    27540

cacttgaaaa acatgtaaaa ataatgtact agagacactt tcaataaagg caaatgcttt    27600

tatttgtaca ctctcgggtg attatttacc cccacccttg ccgtctgcgc cgtttaaaaa    27660

tcaaaggggt tctgccgcgc atcgctatgc gccactggca gggacacgtt gcgatactgg    27720

tgtttagtgc tccacttaaa ctcaggcaca accatccgcg gcagctcggt gaagttttca    27780

ctccacaggc tgcgcaccat caccaacgcg tttagcaggt cgggcgccga tatcttgaag    27840

tcgcagttgg ggcctccgcc ctgcgcgcgc gagttgcgat acacagggtt gcagcactgg    27900

aacactatca gcgccgggtg gtgcacgctg gccagcacgc tcttgtcgga gatcagatcc    27960

gcgtccaggt cctccgcgtt gctcagggcg aacggagtca actttggtag ctgccttccc    28020

aaaaagggcg cgtgcccagg ctttgagttg cactcgcacc gtagtggcat caaaaggtga    28080

ccgtgcccgg tctgggcgtt aggatacagc gcctgcataa aagccttgat ctgcttaaaa    28140

gccacctgag cctttgcgcc ttcagagaag aacatgccgc aagacttgcc ggaaaactga    28200

ttggccggac aggccgcgtc gtgcacgcag caccttgcgt cggtgttgga gatctgcacc    28260

acatttcggc cccaccggtt cttcacgatc ttggccttgc tagactgctc cttcagcgcg    28320

cgctgcccgt tttcgctcgt cacatccatt tcaatcacgt gctccttatt tatcataatg    28380

cttccgtgta gacacttaag ctcgccttcg atctcagcgc agcggtgcag ccacaacgcg    28440

cagcccgtgg gctcgtgatg cttgtaggtc acctctgcaa acgactgcag gtacgcctgc    28500

aggaatcgcc ccatcatcgt cacaaaggtc ttgttgctgg tgaaggtcag ctgcaacccg    28560

cggtgctcct cgttcagcca ggtcttgcat acggccgcca gagcttccac ttggtcaggc    28620

agtagtttga agttcgcctt tagatcgtta tccacgtggt acttgtccat cagcgcgcgc    28680

gcagcctcca tgcccttctc ccacgcagac acgatcggca cactcagcgg gttcatcacc    28740

gtaatttcac tttccgcttc gctgggctct tcctcttcct cttgcgtccg cataccacgc    28800

gccactgggt cgtcttcatt cagccgccgc actgtgcgct tacctccttt gccatgcttg    28860

attagcaccg gtgggttgct gaaacccacc atttgtagcg ccacatcttc tctttcttcc    28920

tcgctgtcca cgattacctc tggtgatggc gggcgctcgg gcttgggaga agggcgcttc    28980

tttttcttct tgggcgcaat ggccaaatcc gccgccgagg tcgatggccg cgggctgggt    29040

gtgcgcggca ccagcgcgtc ttgtgatgag tcttcctcgt cctcggactc gatacgccgc    29100

ctcatccgct tttttggggg cgcccgggga ggcggcggcg acggggacgg ggacgacacg    29160

tcctccatgg ttgggggacg tcgcgccgca ccgcgtccgc gctcgggggt ggtttcgcgc    29220

tgctcctctt cccgactggc catttccttc tcctataggc agaaaaagat catggagtca    29280

gtcgagaaga aggacagcct aaccgccccc tctgagttcg ccaccaccgc ctccaccgat    29340

gccgccaacg cgcctaccac cttccccgtc gaggcacccc cgcttgagga ggaggaagtg    29400

attatcgagc aggacccagg ttttgtaagc gaagacgacg aggaccgctc agtaccaaca    29460

gaggataaaa agcaagacca ggacaacgca gaggcaaacg aggaacaagt cgggcggggg    29520

gacgaaaggc atggcgacta cctagatgtg ggagacgacg tgctgttgaa gcatctgcag    29580

cgccagtgcg ccattatctg cgacgcgttg caagagcgca gcgatgtgcc cctcgccata    29640

gcggatgtca gccttgccta cgaacgccac ctattctcac cgcgcgtacc ccccaaacgc    29700

caagaaaacg gcacatgcga gcccaacccg cgcctcaact tctaccccgt atttgccgtg    29760

ccagaggtgc ttgccaccta tcacatcttt ttccaaaact gcaagatacc cctatcctgc    29820

cgtgccaacc gcagccgagc ggacaagcag ctggccttgc ggcagggcgc tgtcatacct    29880

gatatcgcct cgctcaacga agtgccaaaa atctttgagg gtcttggacg cgacgagaag    29940

cgcgcggcaa acgctctgca acaggaaaac agcgaaaatg aaagtcactc tggagtgttg    30000

gtggaactcg agggtgacaa cgcgcgccta gccgtactaa aacgcagcat cgaggtcacc    30060

cactttgcct acccggcact taacctaccc cccaaggtca tgagcacagt catgagtgag    30120

ctgatcgtgc gccgtgcgca gcccctggag agggatgcaa atttgcaaga acaaacagag    30180

gagggcctac ccgcagttgg cgacgagcag ctagcgcgct ggcttcaaac gcgcgagcct    30240

gccgacttgg aggagcgacg caaactaatg atggccgcag tgctcgttac cgtggagctt    30300

gagtgcatgc agcggttctt tgctgacccg gagatgcagc gcaagctaga ggaaacattg    30360

cactacacct ttcgacaggg ctacgtacgc caggcctgca agatctccaa cgtggagctc    30420

tgcaacctgg tctcctacct tggaattttg cacgaaaacc gccttgggca aaacgtgctt    30480

cattccacgc tcaagggcga ggcgcgccgc gactacgtcc gcgactgcgt ttacttattt    30540

ctatgctaca cctggcagac ggccatgggc gtttggcagc agtgcttgga ggagtgcaac    30600

ctcaaggagc tgcagaaact gctaaagcaa aacttgaagg acctatggac ggccttcaac    30660

gagcgctccg tggccgcgca cctggcggac atcattttcc ccgaacgcct gcttaaaacc    30720

ctgcaacagg gtctgccaga cttcaccagt caaagcatgt tgcagaactt taggaacttt    30780

atcctagagc gctcaggaat cttgcccgcc acctgctgtg cacttcctag cgactttgtg    30840

cccattaagt accgcgaatg ccctccgccg ctttggggcc actgctacct tctgcagcta    30900

gccaactacc ttgcctacca ctctgacata atggaagacg tgagcggtga cggtctactg    30960

gagtgtcact gtcgctgcaa cctatgcacc ccgcaccgct ccctggtttg caattcgcag    31020

ctgcttaacg aaagtcaaat tatcggtacc tttgagctgc agggtccctc gcctgacgaa    31080

aagtccgcgg ctccggggtt gaaactcact ccggggctgt ggacgtcggc ttaccttcgc    31140

aaatttgtac ctgaggacta ccacgcccac gagattaggt tctacgaaga ccaatcccgc    31200

ccgcctaatg cggagcttac cgcctgcgtc attacccagg gccacattct tggccaattg    31260

caagccatca acaaagcccg ccaagagttt ctgctacgaa agggacgggg ggtttacttg    31320

gacccccagt ccggcgagga gctcaaccca atccccccgc cgccgcagcc ctatcagcag    31380

cagccgcggg cccttgcttc ccaggatggc acccaaaaag aagctgcagc tgccgccgcc    31440

acccacggac gaggaggaat actgggacag tcaggcagag gaggttttgg acgaggagga    31500

ggaggacatg atggaagact gggagagcct agacgaggaa gcttccgagg tcgaagaggt    31560

gtcagacgaa acaccgtcac cctcggtcgc attcccctcg ccggcgcccc agaaatcggc    31620

aaccggttcc agcatggcta caacctccgc tcctcaggcg ccgccggcac tgcccgttcg    31680

ccgacccaac cgtagatggg acaccactgg aaccagggcc ggtaagtcca agcagccgcc    31740

gccgttagcc caagagcaac aacagcgcca aggctaccgc tcatggcgcg ggcacaagaa    31800

cgccatagtt gcttgcttgc aagactgtgg gggcaacatc tccttcgccc gccgctttct    31860

tctctaccat cacggcgtgg ccttcccccg taacatcctg cattactacc gtcatctcta    31920

cagcccatac tgcaccggcg gcagcggcag caacagcagc ggccacacag aagcaaaggc    31980

gaccggatag caagactctg acaaagccca agaaatccac agcggcggca gcagcaggag    32040

gaggagcgct gcgtctggcg cccaacgaac ccgtatcgac ccgcgagctt agaaacagga    32100

tttttcccac tctgtatgct atatttcaac agagcagggg ccaagaacaa gagctgaaaa    32160

taaaaaacag gtctctgcga tccctcaccc gcagctgcct gtatcacaaa agcgaagatc    32220

agcttcggcg cacgctggaa gacgcggagg ctctcttcag taaatactgc gcgctgactc    32280

ttaaggacta gtttcgcgcc ctttctcaaa tttaagcgcg aaaactacgt catctccagc    32340

ggccacaccc ggcgccagca cctgttgtca gcgccattat gagcaaggaa attcccacgc    32400

cctacatgtg gagttaccag ccacaaatgg gacttgcggc tggagctgcc caagactact    32460

caacccgaat aaactacatg agcgcgggac cccacatgat atcccgggtc aacggaatac    32520

gcgcccaccg aaaccgaatt ctcctggaac aggcggctat taccaccaca cctcgtaata    32580

accttaatcc ccgtagttgg cccgctgccc tggtgtacca ggaaagtccc gctcccacca    32640

ctgtggtact tcccagagac gcccaggccg aagttcagat gactaactca ggggcgcagc    32700

ttgcgggcgg ctttcgtcac agggtgcggt cgcccgggca gggtataact cacctgacaa    32760

tcagagggcg aggtattcag ctcaacgacg agtcggtgag ctcctcgctt ggtctccgtc    32820

cggacgggac atttcagatc ggcggcgccg gccgctcttc attcacgcct cgtcaggcaa    32880

tcctaactct gcagacctcg tcctctgagc cgcgctctgg aggcattgga actctgcaat    32940

ttattgagga gtttgtgcca tcggtctact ttaacccctt ctcgggacct cccggccact    33000

atccggatca atttattcct aactttgacg cggtaaagga ctcggcggac ggctacgact    33060

gaatgttaag tggagaggca gagcaactgc gcctgaaaca cctggtccac tgtcgccgcc    33120

acaagtgctt tgcccgcgac tccggtgagt tttgctactt tgaattgccc gaggatcata    33180

tcgagggccc ggcgcacggc gtccggctta ccgcccaggg agagcttgcc cgtagcctga    33240

ttcgggagtt tacccagcgc cccctgctag ttgagcggga caggggaccc tgtgttctca    33300

ctgtgatttg caactgtcct aaccctggat tacatcaaga tcctctagtt aatgtcaggt    33360

cgcctaagtc gattaactag agtacccggg gatcttattc cctttaacta ataaaaaaaa    33420

ataataaagc atcacttact taaaatcagt tagcaaattt ctgtccagtt tattcagcag    33480

cacctccttg ccctcctccc agctctggta ttgcagcttc ctcctggctg caaactttct    33540

ccacaatcta aatggaatgt cagtttcctc ctgttcctgt ccatccgcac ccactatctt    33600

catgttgttg cagatgaagc gcgcaagacc gtctgaagat accttcaacc ccgtgtatcc    33660

atatgacacg gaaaccggtc ctccaactgt gccttttctt actcctccct ttgtatcccc    33720

caatgggttt caagagagtc cccctggggt actctctttg cgcctatccg aacctctagt    33780

tacctccaat ggcatgcttg cgctcaaaat gggcaacggc ctctctctgg acgaggccgg    33840

caaccttacc tcccaaaatg taaccactgt gagcccacct ctcaaaaaaa ccaagtcaaa    33900

cataaacctg gaaatatctg cacccctcac agttacctca gaagccctaa ctgtggctgc    33960

cgccgcacct ctaatggtcg cgggcaacac actcaccatg caatcacagg ccccgctaac    34020

cgtgcacgac tccaaactta gcattgccac ccaaggaccc ctcacagtgt cagaaggaaa    34080

gctagccctg caaacatcag gccccctcac caccaccgat agcagtaccc ttactatcac    34140

tgcctcaccc cctctaacta ctgccactgg tagcttgggc attgacttga aagagcccat    34200

ttatacacaa aatggaaaac taggactaaa gtacggggct cctttgcatg taacagacga    34260

cctaaacact ttgaccgtag caactggtcc aggtgtgact attaataata cttccttgca    34320

aactaaagtt actggagcct tgggttttga ttcacaaggc aatatgcaac ttaatgtagc    34380

aggaggacta aggattgatt ctcaaaacag acgccttata cttgatgtta gttatccgtt    34440

tgatgctcaa aaccaactaa atctaagact aggacagggc cctcttttta taaactcagc    34500

ccacaacttg gatattaact acaacaaagg cctttacttg tttacagctt caaacaattc    34560

caaaaagctt gaggttaacc taagcactgc caaggggttg atgtttgacg ctacagccat    34620

agccattaat gcaggagatg ggcttgaatt tggttcacct aatgcaccaa acacaaatcc    34680

cctcaaaaca aaaattggcc atggcctaga atttgattca aacaaggcta tggttcctaa    34740

actaggaact ggccttagtt ttgacagcac aggtgccatt acagtaggaa acaaaaataa    34800

tgataagcta actttgtgga ccacaccagc tccatctcct aactgtagac taaatgcaga    34860

gaaagatgct aaactcactt tggtcttaac aaaatgtggc agtcaaatac ttgctacagt    34920

ttcagttttg gctgttaaag gcagtttggc tccaatatct ggaacagttc aaagtgctca    34980

tcttattata agatttgacg aaaatggagt gctactaaac aattccttcc tggacccaga    35040

atattggaac tttagaaatg gagatcttac tgaaggcaca gcctatacaa acgctgttgg    35100

atttatgcct aacctatcag cttatccaaa atctcacggt aaaactgcca aaagtaacat    35160

tgtcagtcaa gtttacttaa acggagacaa aactaaacct gtaacactaa ccattacact    35220

aaacggtaca caggaaacag gagacacaac tccaagtgca tactctatgt cattttcatg    35280

ggactggtct ggccacaact acattaatga aatatttgcc acatcctctt acactttttc    35340

atacattgcc caagaataaa gaatcgtttg tgttatgttt caacgtgttt atttttcaat    35400

tgcagaaaat ttcaagtcat ttttcattca gtagtatagc cccaccacca catagcttat    35460

acagatcacc gtaccttaat caaactcaca gaaccctagt attcaacctg ccacctccct    35520

cccaacacac agagtacaca gtcctttctc cccggctggc cttaaaaagc atcatatcat    35580

gggtaacaga catattctta ggtgttatat tccacacggt ttcctgtcga gccaaacgct    35640

catcagtgat attaataaac tccccgggca gctcacttaa gttcatgtcg ctgtccagct    35700

gctgagccac aggctgctgt ccaacttgcg gttgcttaac gggcggcgaa ggagaagtcc    35760

acgcctacat gggggtagag tcataatcgt gcatcaggat agggcggtgg tgctgcagca    35820

gcgcgcgaat aaactgctgc cgccgccgct ccgtcctgca ggaatacaac atggcagtgg    35880

tctcctcagc gatgattcgc accgcccgca gcataaggcg ccttgtcctc cgggcacagc    35940

agcgcaccct gatctcactt aaatcagcac agtaactgca gcacagcacc acaatattgt    36000

tcaaaatccc acagtgcaag gcgctgtatc caaagctcat ggcggggacc acagaaccca    36060

cgtggccatc ataccacaag cgcaggtaga ttaagtggcg acccctcata aacacgctgg    36120

acataaacat tacctctttt ggcatgttgt aattcaccac ctcccggtac catataaacc    36180

tctgattaaa catggcgcca tccaccacca tcctaaacca gctggccaaa acctgcccgc    36240

cggctataca ctgcagggaa ccgggactgg aacaatgaca gtggagagcc caggactcgt    36300

aaccatggat catcatgctc gtcatgatat caatgttggc acaacacagg cacacgtgca    36360

tacacttcct caggattaca agctcctccc gcgttagaac catatcccag ggaacaaccc    36420

attcctgaat cagcgtaaat cccacactgc agggaagacc tcgcacgtaa ctcacgttgt    36480

gcattgtcaa agtgttacat tcgggcagca gcggatgatc ctccagtatg gtagcgcggg    36540

tttctgtctc aaaaggaggt agacgatccc tactgtacgg agtgcgccga gacaaccgag    36600

atcgtgttgg tcgtagtgtc atgccaaatg gaacgccgga cgtagtcata tttcctgaag    36660

caaaaccagg tgcgggcgtg acaaacagat ctgcgtctcc ggtctcgccg cttagatcgc    36720

tctgtgtagt agttgtagta tatccactct ctcaaagcat ccaggcgccc cctggcttcg    36780

ggttctatgt aaactccttc atgcgccgct gccctgataa catccaccac cgcagaataa    36840

gccacaccca gccaacctac acattcgttc tgcgagtcac acacgggagg agcgggaaga    36900

gctggaagaa ccatgttttt ttttttattc caaaagatta tccaaaacct caaaatgaag    36960

atctattaag tgaacgcgct cccctccggt ggcgtggtca aactctacag ccaaagaaca    37020

gataatggca tttgtaagat gttgcacaat ggcttccaaa aggcaaacgg ccctcacgtc    37080

caagtggacg taaaggctaa acccttcagg gtgaatctcc tctataaaca ttccagcacc    37140

ttcaaccatg cccaaataat tctcatctcg ccaccttctc aatatatctc taagcaaatc    37200

ccgaatatta agtccggcca ttgtaaaaat ctgctccaga gcgccctcca ccttcagcct    37260

caagcagcga atcatgattg caaaaattca ggttcctcac agacctgtat aagattcaaa    37320

agcggaacat taacaaaaat accgcgatcc cgtaggtccc ttcgcagggc cagctgaaca    37380

taatcgtgca ggtctgcacg gaccagcgcg gccacttccc cgccaggaac catgacaaaa    37440

gaacccacac tgattatgac acgcatactc ggagctatgc taaccagcgt agccccgatg    37500

taagcttgtt gcatgggcgg cgatataaaa tgcaaggtgc tgctcaaaaa atcaggcaaa    37560

gcctcgcgca aaaaagaaag cacatcgtag tcatgctcat gcagataaag gcaggtaagc    37620

tccggaacca ccacagaaaa agacaccatt tttctctcaa acatgtctgc gggtttctgc    37680

ataaacacaa aataaaataa caaaaaaaca tttaaacatt agaagcctgt cttacaacag    37740

gaaaaacaac ccttataagc ataagacgga ctacggccat gccggcgtga ccgtaaaaaa    37800

actggtcacc gtgattaaaa agcaccaccg acagctcctc ggtcatgtcc ggagtcataa    37860

tgtaagactc ggtaaacaca tcaggttgat tcacatcggt cagtgctaaa aagcgaccga    37920

aatagcccgg gggaatacat acccgcaggc gtagagacaa cattacagcc cccataggag    37980

gtataacaaa attaatagga gagaaaaaca cataaacacc tgaaaaaccc tcctgcctag    38040

gcaaaatagc accctcccgc tccagaacaa catacagcgc ttccacagcg gcagccataa    38100

cagtcagcct taccagtaaa aaagaaaacc tattaaaaaa acaccactcg acacggcacc    38160

agctcaatca gtcacagtgt aaaaaagggc caagtgcaga gcgagtatat ataggactaa    38220

aaaatgacgt aacggttaaa gtccacaaaa aacacccaga aaaccgcacg cgaacctacg    38280

cccagaaacg aaagccaaaa aacccacaac ttcctcaaat cgtcacttcc gttttcccac    38340

gttacgtcac ttcccatttt aagaaaacta caattcccaa cacatacaag ttactccgcc    38400

ctaaaaccta cgtcacccgc cccgttccca cgccccgcgc cacgtcacaa actccacccc    38460

ctcattatca tattggcttc aatccaaaat aaggta                              38496


<210>  227
<211>  9701
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  vector for IgG1 against T27Y H34A H374N ACE2 mutant


<220>
<221>  misc_feature
<222>  (2929)..(2930)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (2934)..(2934)
<223>  n is a, c, g, or t

<400>  227
ggcgtaatct gctgcttgca aacaaaaaaa ccaccgctac cagcggtggt ttgtttgccg       60

gatcaagagc taccaactct ttttccgaag gtaactggct tcagcagagc gcagatacca      120

aatactgtcc ttctagtgta gccgtagtta ggccaccact tcaagaactc tgtagcaccg      180

cctacatacc tcgctctgct gaagccagtt accagtggct gctgccagtg gcgataagtc      240

gtgtcttacc gggttggact caagagatag ttaccggata aggcgcagcg gtcgggctga      300

acggggggtt cgtgcacaca gcccagcttg gagcgaacga cctacaccga actgagatac      360

ctacagcgtg agctatgaga aagcgccacg cttcccgaag ggagaaaggc ggacaggtat      420

ccggtaagcg gcagggtcgg aacaggagag cgcacgaggg agcttccagg gggaaacgcc      480

tggtatcttt atagtcctgt cgggtttcgc cacctctgac ttgagcgtcg atttttgtga      540

tgctcgtcag gggggcggag cctatggaaa aacgccagca acgcaagcta gagtttaaac      600

ttgacagatg agacaataac cctgataaat gcttcaataa tattgaaaaa ggaaaagtat      660

gagtattcaa catttccgtg tcgcccttat tccctttttt gcggcatttt gccttcctgt      720

ttttgctcac ccagaaacgc tggtgaaagt aaaagatgca gaagatcact tgggtgcgcg      780

agtgggttac atcgaactgg atctcaacag cggtaagatc cttgagagtt ttcgccccga      840

agaacgtttc ccaatgatga gcacttttaa agttctgcta tgtggcgcgg tattatcccg      900

tattgatgcc gggcaagagc aactcggtcg ccgcatacac tattctcaga atgacttggt      960

tgaatactca ccagtcacag aaaagcatct tacggatggc atgacagtaa gagaattatg     1020

cagtgctgcc ataaccatga gtgataacac tgcggccaac ttacttctga caactatcgg     1080

aggaccgaag gagctaaccg cttttttgca caacatgggg gatcatgtaa ctcgccttga     1140

tcgttgggaa ccggagctga atgaagccat accaaacgac gagcgtgaca ccacgatgcc     1200

tgtagcaatg gcaacaacgt tgcgaaaact attaactggc gaactactta ctctagcttc     1260

ccggcaacaa ctaatagact ggatggaggc ggataaagtt gcaggaccac ttctgcgctc     1320

ggcacttccg gctggctggt ttattgctga taaatcagga gccggtgagc gtgggtcacg     1380

cggtatcatt gcagcactgg ggccggatgg taagccctcc cgtatcgtag ttatctacac     1440

tacggggagt caggcaacta tggatgaacg aaatagacag atcgctgaga taggtgcctc     1500

actgattaag cattggtaag gataaatttc tggtaaggag gacacgtatg gaagtgggca     1560

agttggggaa gccgtatccg ttgctgaatc tggcatatgt gggagtataa gacgcgcagc     1620

gtcgcatcag gcattttttt ctgcgccaat gcaaaaaggc catccgtcag gatggccttt     1680

cggcataact agggccgccg atatttgaaa atatggcata ttgaaaatgt cgccgatgtg     1740

agtttctgtg taactgatat cgccattttt ccaaaagtga tttttgggca tacgcgatat     1800

ctggcgatag cgcttatatc gtttacgggg gatggcgata gacgactttg gtgacttggg     1860

cgattctgtg tgtcgcaaat atcgcagttt cgatataggt gacagacgat atgaggctat     1920

atcgccgata gaggcgacat caagctggca catggccaat gcatatcgat ctatacattg     1980

aatcaatatt ggccattagc catattattc attggttata tagcataaat caatattggc     2040

tattggccat tgcatacgtt gtatccatat cataatatgt acatttatat tggctcatgt     2100

ccaacattac cgccatgttg acattgatta ttgactagtt attaatagta atcaattacg     2160

gggtcattag ttcatagccc atatatggag ttccgcgtta cataacttac ggtaaatggc     2220

ccgcctggct gaccgcccaa cgacccccgc ccattgacgt caataatgac gtatgttccc     2280

atagtaacgc caatagggac tttccattga cgtcaatggg tggagtattt acggtaaact     2340

gcccacttgg cagtacatca agtgtatcat atgccaagta cgccccctat tgacgtcaat     2400

gacggtaaat ggcccgcctg gcattatgcc cagtacatga ccttatggga ctttcctact     2460

tggcagtaca tctacgtatt agtcatcgct attaccatgg tgatgcggtt ttggcagtac     2520

atcaatgggc gtggatagcg gtttgactca cggggatttc caagtctcca ccccattgac     2580

gtcaatggga gtttgttttg gcaccaaaat caacgggact ttccaaaatg tcgtaacaac     2640

tccgccccat tgacgcaaat gggcggtagg cgtgtacggt gggaggtcta tataagcaga     2700

gctcgtttag tgaaccgtca gatcgcctgg agacgccatc cacgctgttt tgacctccat     2760

agaagacacc gggaccgatc cagcctccgc ggccgggaac ggtgcattgg aacgcggatt     2820

ccccgtgcca agagtgacgt aagtaccgcc tatagagtct ataggcccac ccccttggct     2880

tcttatgcat gctatactgt ttttggcttg gggtctatac accccccgnn ttcntcatgt     2940

tataggtgat ggtatagctt agcctatagg tgtgggttat tgaccattat tgaccactcc     3000

ccctattggt gacgatactt tccattacta atccataaca tggctctttg ccacaactct     3060

ctttattggc tatatgccaa tacactgtcc ttcagagact gacacggact ctgtattttt     3120

acaggatggg gtctcattta ttatttacaa attcacatat acaacaccac cgtccccagt     3180

gcccgcagtt tttattaaac ataacgtggg atctccacgc gaatctcggg tacgtgttcc     3240

ggacatgggc tcttctccgg tagcggcgga gcttctacat ccgagccctg ctcccatgcc     3300

tccagcgact catggtcgct cggcagctcc ttgctcctaa cagtggaggc cagacttagg     3360

cacagcacga tgcccaccac caccagtgtg ccgcacaagg ccgtggcggt agggtatgtg     3420

tctgaaaatg agctcgggga gcgggcttgc accgctgacg catttggaag acttaaggca     3480

gcggcagaag aagatgcagg cagctgagtt gttgtgttct gataagagtc agaggtaact     3540

cccgttgcgg tgctgttaac ggtggagggc agtgtagtct gagcagtact cgttgctgcc     3600

gcgcgcgcca ccagacataa tagctgacag actaacagac tgttcctttc catgggtctt     3660

ttctgcagtc accgtccttg acacgaagct gctagcgcca ccatgagcag cagtagttgg     3720

cttctcttga gtttggtggc agtgacagca gcccagagta ctatcgagga gcaggctaaa     3780

tactttctgg ataagtttaa cgccgaggcc gaagacttgt tctatcaatc ttctctcgct     3840

tcatggaatt acaatactaa catcactgag gagaacgtcc agaatatgaa caatgctggc     3900

gacaaatgga gcgccttctt gaaggagcag tctacccttg cacaaatgta tccactgcag     3960

gagatacaga accttacagt aaagttgcag ctccaggctc tccagcagaa cggatctagc     4020

gtgctttcag aggataaaag caaaaggctg aacaccatac ttaataccat gtccacaatt     4080

tactctactg gtaaagtatg taaccccgac aaccctcaag aatgcctcct tcttgagcca     4140

ggcctcaatg agatcatggc taatagtctg gactataatg aaagactgtg ggcatgggag     4200

tcctggagat ctgaagtagg gaagcaactg aggccccttt atgaagagta cgtcgtactt     4260

aagaatgaaa tggcccgcgc taaccactac gaggattacg gcgattactg gcgtggggac     4320

tatgaagtaa atggtgtaga tggatacgac tatagtcgtg ggcaattgat tgaggatgtg     4380

gagcacactt ttgaggagat aaaaccactc tatgagcatc ttcacgcata tgtgagagct     4440

aaactgatga acgcctaccc aagttacatc agtccaatcg gatgtctccc agctcacctc     4500

cttggcgaca tgtggggacg tttctggacc aatctgtatt ccctcacagt ccctttcggg     4560

caaaagccta atatagacgt gacagacgca atggttgatc aggcttggga tgctcaaagg     4620

atttttaagg aagctgagaa gttttttgtg tcagtcggtt tgccaaatat gacacaaggc     4680

ttctgggaaa atagcatgtt gactgatccc ggtaatgttc aaaaggctgt gtgtcaccct     4740

accgcttggg accttgggaa aggtgacttt cgaatcttga tgtgtaccaa ggtgacaatg     4800

gatgactttc ttacagccca taatgaaatg ggtcacatcc agtatgatat ggcttatgca     4860

gctcaacctt tcctcttgag aaatggtgca aatgaaggtt ttcatgaagc tgtaggggaa     4920

ataatgtccc tgagtgctgc aaccccaaag catctcaaga gtatcggatt gttgagccca     4980

gattttcaag aagataacga gaccgaaatc aacttccttc tgaaacaagc cctcacaata     5040

gttggtactc ttccattcac atacatgctg gagaaatggc gttggatggt ttttaagggg     5100

gagataccta aagatcagtg gatgaaaaag tggtgggaga tgaagcgtga gatcgtaggg     5160

gtcgtggagc cagtgcctca tgatgagact tactgtgacc cagcatcact cttccacgtt     5220

agcaatgact attcatttat acgttattac actcgcactc tttaccagtt tcaatttcag     5280

gaggctctgt gtcaggctgc caagcatgag ggaccccttc acaagtgtga tattagtaac     5340

agtactgagg caggccaaaa actgttcaat atgttgaggc ttggcaaaag cgagccatgg     5400

actctcgcct tggaaaatgt tgtcggggct aaaaacatga atgtacgccc tctgcttaac     5460

tattttgagc ccctttttac atggctcaag gaccagaata agaactcctt tgtcggctgg     5520

tcaacagact ggtctcccta tgcagacaaa acacatactt gcccaccttg tcctgcacca     5580

gagctgctgg gaggtccaag cgtgttcctg tttccaccca agcccaaaga cacactgatg     5640

atttctcgaa ctccagaagt gacctgcgtg gtcgtggacg tgagccacga ggatcccgaa     5700

gtgaagttca actggtacgt ggatggcgtg gaggtccata atgctaagac taaaccccgg     5760

gaggaacagt acaacagcac ttatagggtc gtgtccgtgc tgaccgtcct gcatcaggat     5820

tggctgaacg ggaaggaata taagtgcaaa gtgtctaata aggcactgcc cgcccctatc     5880

gagaaaacaa ttagcaaggc taagggtcag cctagagaac cacaggtgta cactctgcct     5940

ccaagtcgcg acgagctgac caagaaccag gtgtcactga catgtctggt caaaggcttt     6000

tatccctcag atatcgcagt ggagtgggaa agcaatggac agcctgagaa caattacaag     6060

accacacccc ctgtgctgga cagtgatggc tcattctttc tgtattctaa gctgacagtg     6120

gacaaaagta ggtggcagca gggaaacgtg ttctcctgct ctgtcatgca cgaagcactg     6180

cacaatcatt atacccagaa gagtctgtca ctgagccctg gcaaatgagc gataccgatt     6240

ctagaactag atcataatca gccataccac atttgtagag gttttacttg ctttaaaaaa     6300

cctcccacac ctccccctga acctgaaaca taaaatgaat gcaattgttg ttgttaactt     6360

gtttattgca gcttataatg gttacaaata aagcaatagc atcacaaatt tcacaaataa     6420

agcatttttt tcactgcatt ctagttgtgg tttgtccaaa ctcatcaatg tatcttaagg     6480

ccgcaggtaa gccagcccag gcctcgccct ccagctcaag gcgggacagg tgccctagag     6540

tagcctgcat ccagggacag gccccagccg ggtgctgaca cgtccacctc catctcttcc     6600

tcaggtctgc ccgggtggca tccctgtgac ccctccccag tgcctctcct ggtcgtggaa     6660

ggtgctactc cagtgcccac cagccttgtc ctaataaaat taagttgcat cattttgttt     6720

gactaggtgt ccttgtataa tattatgggg tggaggcggg tggtatggag caaggggccc     6780

aagttaactt gtttattgca gcttataatg gttacaaata aagcaatagc atcacaaatt     6840

tcacaaataa agcatttttt tcactgcatt ctagttgtgg tttgtccaaa ctcatcaatg     6900

tatcttatca tgtctggatc cgcttcaggc accgggcttg cgggtcatgc accaggtgcg     6960

cggtccttcg ggcacctcga cgtcggcggt gacggtgaag ccgagccgct cgtagaaggg     7020

gaggttgcgg ggcgcggagg tctccaggaa ggcgggcacc ccggcgcgct cggccgcctc     7080

cactccgggg agcacgacgg cgctgcccag acccttgccc tggtggtcgg gcgagacgcc     7140

gacggtggcc aggaaccacg cgggctcctt gggccggtgc ggcgccagga ggccttccat     7200

ctgttgctgc gcggccagcc tggaaccgct caactcggcc atgcgcgggc cgatctcggc     7260

gaacaccgcc cccgcttcga cgctctccgg cgtggtccag accgccaccg cggcgccgtc     7320

gtccgcgacc cacaccttgc cgatgtcgag cccgacgcgc gtgaggaaga gttcttgcag     7380

ctcggtgacc cgctcgatgt ggcggtccgg gtcgacggtg tggcgcgtgg cggggtagtc     7440

ggcgaacgcg gcggcgaggg tgcgtacggc ccgggggacg tcgtcgcggg tggcgaggcg     7500

caccgtgggc ttgtactcgg tcatggtggc ctgcagagtc gctctgtgtt cgaggccaca     7560

cgcgtcacct taatatgcga agtggacctg ggaccgcgcc gccccgactg catctgcgtg     7620

ttttcgccaa tgacaagacg ctgggcgggg tttgtgtcat catagaacta aagacatgca     7680

aatatatttc ttccggggac accgccagca aacgcgagca acgggccacg gggatgaagc     7740

agctgcgcca ctccctgaag atccatcgtc tcctaacaag ttacatcact cctgcccttc     7800

ctcaccctca tctccatcac ctccttcatc tccgtcatct ccgtcatcac cctccgcggc     7860

agccccttcc accataggtg gaaaccaggg aggcaaatct actccatcgt caaagctgca     7920

cacagtcacc ctgatattgc aggtaggagc gggctttgtc ataacaaggt ccttaatcgc     7980

atccttcaaa acctcagcaa atatatgagt ttgtaaaaag accatgaaat aacagacaat     8040

ggactccctt agcgggccag gttgtgggcc gggtccaggg gccattccaa aggggagacg     8100

actcaatggt gtaagacgac attgtggaat agcaagggca gttcctcgcc ttaggttgta     8160

aagggaggtc ttactacctc catatacgaa cacaccggcg acccaagttc cttcgtcggt     8220

agtcctttct acgtgactcc tagccaggag agctcttaaa ccttctgcaa tgttctcaaa     8280

tttcgggttg gaacctcctt gaccacgatg ctttccaaac caccctcctt ttttgcgcct     8340

gcctccatca ccctgacccc cgctgcgcgg gggcacgtca ggctcaccat ctgggccgcc     8400

ttcttggtgg tattcaaaat aatcggcttc ccctacaggg tggaaaaatg gccttctacc     8460

tggagggggc ctgcgcggtg gagacccgga tgatgatgac tgactactgg gactcctggg     8520

cctcttttct ccacgtccac gacctctccc cctggctctt tcacgacttc cccccctggc     8580

tctttcacgt cctctacccc ggcggcctcc actacctcct cgaccccggc ctccactacc     8640

tcctcgaccc cggcctccac tgcctcctcg accccggcct ccacctcctg ctcctgcccc     8700

tcccgctcct gctcctgctc ctgttccacc gtgggtccct ttgcagccaa tgcaacttgg     8760

acgtttttgg ggtctccgga caccatctct atgtcttggc cctgatcctg agccgcccgg     8820

ggctcctggt cttccgcctc ctcgtcctcg tcctcttccc cgtcctcgtc catgtgccat     8880

gatggcggcc tgcagctgtg ttcgaggccg cgcgtgtcac cttaatatgc gaagtggacc     8940

tgggaccgcg ccgccccgac tgcatctgcg tgttcgagtt cgccaatgac aagacgctgg     9000

gcggggagat cccccttatt aaccctaaac gggtagcata tgcttcccgg gtagtagtat     9060

atactatcca gactaaccct aattcaatag catatgttac ccaacgggaa gcatatgcta     9120

tcgaattagg gttagtaaaa gggtcctaag gaacagcgat ctggatagca tatgctatcc     9180

taatctatat ctgggtagca tatgctatcc taatctatat ctgggtagca taggctatcc     9240

taatctatat ctgggtagca tatgctatcc taatctatat ctgggtagta tatgctatcc     9300

taatttatat ctgggtagca taggctatcc taatctatat ctgggtagca tatgctatcc     9360

taatctatat ctgggtagta tatgctatcc taatctgtat ccgggtagca tatgctatcc     9420

tcatgcatat acagtcagca tatgataccc agtagtagag tgggagtgct atcctttgca     9480

tatgccgcca cctcccaagg agatctgtcg acatcgatgg gcgcgggtgt acactccgcc     9540

catcccgccc ctaactccgc ccagttccgc ccattctccg cctcatggct gactaatttt     9600

ttttatttat gcagaggccg aggccgcctc ggcctctgag ctattccaga agtagtgagg     9660

aggctttttt ggaggcctag gcttttgcaa aaagctaatt c                         9701


<210>  228
<211>  38496
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  vector for IgA against T27Y H34A H378N ACE2 mutant

<400>  228
tattattgat gatgttaatt aacatgcatg gatcctacgt ctcgaccgat gcccttgaga       60

gccttcaacc cagtcagctc cttccggtgg gcgcggggca tgactatcgt cgccgcactt      120

atgactgtct tctttatcat gcaactcgta ggacaggtgc cggcagcgct ctgggtcatt      180

ttcggcgagg accgctttcg ctggagcgcg acgatgatcg gcctgtcgct tgcggtattc      240

ggaatcttgc acgccctcgc tcaagccttc gtcactggtc ccgccaccaa acgtttcggc      300

gagaagcagg ccattatcgc cggcatggcg gccgacgcgc tgggctacgt cttgctggcg      360

ttcgcgacgc gaggctggat ggccttcccc attatgattc ttctcgcttc cggcggcatc      420

gggatgcccg cgttgcaggc catgctgtcc aggcaggtag atgacgacca tcagggacag      480

cttcaaggat cgctcgcggc tcttaccagc ctaacttcga tcattggacc gctgatcgtc      540

acggcgattt atgccgcctc ggcgagcaca tggaacgggt tggcatggat tgtaggcgcc      600

gccctatacc ttgtctgcct ccccgcgttg cgtcgcggtg catggagccg ggccacctcg      660

acctgaatgg aagccggcgg cacctcgcta acggattcac cactccaaga attggagcca      720

atcaattctt gcggagaact gtgaatgcgc aaaccaaccc ttggcagaac atatccatcg      780

cgtccgccat ctccagcagc cgcacgcggc gcatctcggg cagcgttggg tcctggccac      840

gggtgcgcat gatcgtgctc ctgtcgttga ggacccggct aggctggcgg ggttgcctta      900

ctggttagca gaatgaatca ccgatacgcg agcgaacgtg aagcgactgc tgctgcaaaa      960

cgtctgcgac ctgagcaaca acatgaatgg tcttcggttt ccgtgtttcg taaagtctgg     1020

aaacgcggaa gtcagcgccc tgcaccatta tgttccggat ctgcatcgca ggatgctgct     1080

ggctaccctg tggaacacct acatctgtat taacgaagcg ctggcattga ccctgagtga     1140

tttttctctg gtcccgccgc atccataccg ccagttgttt accctcacaa cgttccagta     1200

accgggcatg ttcatcatca gtaacccgta tcgtgagcat cctctctcgt ttcatcggta     1260

tcattacccc catgaacaga aatccccctt acacggaggc atcagtgacc aaacaggaaa     1320

aaaccgccct taacatggcc cgctttatca gaagccagac attaacgctt ctggagaaac     1380

tcaacgagct ggacgcggat gaacaggcag acatctgtga atcgcttcac gaccacgctg     1440

atgagcttta ccgcagctgc ctcgcgcgtt tcggtgatga cggtgaaaac ctctgacaca     1500

tgcagctccc ggagacggtc acagcttgtc tgtaagcgga tgccgggagc agacaagccc     1560

gtcagggcgc gtcagcgggt gttggcgggt gtcggggcgc agccatgacc cagtcacgta     1620

gcgatagcgg agtgtatact ggcttaacta tgcggcatca gagcagattg tactgagagt     1680

gcaccatatg cggtgtgaaa taccgcacag atgcgtaagg agaaaatacc gcatcaggcg     1740

ctcttccgct tcctcgctca ctgactcgct gcgctcggtc gttcggctgc ggcgagcggt     1800

atcagctcac tcaaaggcgg taatacggtt atccacagaa tcaggggata acgcaggaaa     1860

gaacatgtga gcaaaaggcc agcaaaaggc caggaaccgt aaaaaggccg cgttgctggc     1920

gtttttccat aggctccgcc cccctgacga gcatcacaaa aatcgacgct caagtcagag     1980

gtggcgaaac ccgacaggac tataaagata ccaggcgttt ccccctggaa gctccctcgt     2040

gcgctctcct gttccgaccc tgccgcttac cggatacctg tccgcctttc tcccttcggg     2100

aagcgtggcg ctttctcata gctcacgctg taggtatctc agttcggtgt aggtcgttcg     2160

ctccaagctg ggctgtgtgc acgaaccccc cgttcagccc gaccgctgcg ccttatccgg     2220

taactatcgt cttgagtcca acccggtaag acacgactta tcgccactgg cagcagccac     2280

tggtaacagg attagcagag cgaggtatgt aggcggtgct acagagttct tgaagtggtg     2340

gcctaactac ggctacacta gaaggacagt atttggtatc tgcgctctgc tgaagccagt     2400

taccttcgga aaaagagttg gtagctcttg atccggcaaa caaaccaccg ctggtagcgg     2460

tggttttttt gtttgcaagc agcagattac gcgcagaaaa aaaggatctc aagaagatcc     2520

tttgatcttt tctacggggt ctgacgctca gtggaacgaa aactcacgtt aagggatttt     2580

ggtcatgaga ttatcaaaaa ggatcttcac ctagatcctt ttaaattaaa aatgaagttt     2640

taaatcaatc taaagtatat atgagtaaac ttggtctgac agttaccaat gcttaatcag     2700

tgaggcacct atctcagcga tctgtctatt tcgttcatcc atagttgcct gactccccgt     2760

cgtgtagata actacgatac gggagggctt accatctggc cccagtgctg caatgatacc     2820

gcgagaccca cgctcaccgg ctccagattt atcagcaata aaccagccag ccggaagggc     2880

cgagcgcaga agtggtcctg caactttatc cgcctccatc cagtctatta attgttgccg     2940

ggaagctaga gtaagtagtt cgccagttaa tagtttgcgc aacgttgttg ccattgctgc     3000

agccatgaga ttatcaaaaa ggatcttcac ctagatcctt ttcacgtaga aagccagtcc     3060

gcagaaacgg tgctgacccc ggatgaatgt cagctactgg gctatctgga caagggaaaa     3120

cgcaagcgca aagagaaagc aggtagcttg cagtgggctt acatggcgat agctagactg     3180

ggcggtttta tggacagcaa gcgaaccgga attgccagct ggggcgccct ctggtaaggt     3240

tgggaagccc tgcaaagtaa actggatggc tttcttgccg ccaaggatct gatggcgcag     3300

gggatcaagc tctgatcaag agacaggatg aggatcgttt cgcatgattg aacaagatgg     3360

attgcacgca ggttctccgg ccgcttgggt ggagaggcta ttcggctatg actgggcaca     3420

acagacaatc ggctgctctg atgccgccgt gttccggctg tcagcgcagg ggcgcccggt     3480

tctttttgtc aagaccgacc tgtccggtgc cctgaatgaa ctgcaagacg aggcagcgcg     3540

gctatcgtgg ctggccacga cgggcgttcc ttgcgcagct gtgctcgacg ttgtcactga     3600

agcgggaagg gactggctgc tattgggcga agtgccgggg caggatctcc tgtcatctca     3660

ccttgctcct gccgagaaag tatccatcat ggctgatgca atgcggcggc tgcatacgct     3720

tgatccggct acctgcccat tcgaccacca agcgaaacat cgcatcgagc gagcacgtac     3780

tcggatggaa gccggtcttg tcgatcagga tgatctggac gaagagcatc aggggctcgc     3840

gccagccgaa ctgttcgcca ggctcaaggc gagcatgccc gacggcgagg atctcgtcgt     3900

gacccatggc gatgcctgct tgccgaatat catggtggaa aatggccgct tttctggatt     3960

catcgactgt ggccggctgg gtgtggcgga ccgctatcag gacatagcgt tggctacccg     4020

tgatattgct gaagagcttg gcggcgaatg ggctgaccgc ttcctcgtgc tttacggtat     4080

cgccgctccc gattcgcagc gcatcgcctt ctatcgcctt cttgacgagt tcttctgaat     4140

tttgttaaaa tttttgttaa atcagctcat tttttaacca ataggccgaa atcggcaaaa     4200

tcccttataa atcaaaagaa tagaccgaga tagggttgag tgttgttcca gtttggaaca     4260

agagtccact attaaagaac gtggactcca acgtcaaagg gcgaaaaacc gtctatcagg     4320

gcgatggccc actacgtgaa ccatcaccct aatcaagttt tttggggtcg aggtgccgta     4380

aagcactaaa tcggaaccct aaagggagcc cccgatttag agcttgacgg ggaaagccgg     4440

cgaacgtggc gagaaaggaa gggaagaaag cgaaaggagc gggcgctagg gcgctggcaa     4500

gtgtagcggt cacgctgcgc gtaaccacca cacccgccgc gcttaatgcg ccgctacagg     4560

gcgcgtccat tcgccattca ggatcgaatt aattcttaat taacatcatc aataatatac     4620

cttattttgg attgaagcca atatgataat gagggggtgg agtttgtgac gtggcgcggg     4680

gcgtgggaac ggggcgggtg acgtagtagt gtggcggaag tgtgatgttg caagtgtggc     4740

ggaacacatg taagcgacgg atgtggcaaa agtgacgttt ttggtgtgcg ccggtgtaca     4800

caggaagtga caattttcgc gcggttttag gcggatgttg tagtaaattt gggcgtaacc     4860

gagtaagatt tggccatttt cgcgggaaaa ctgaataaga ggaagtgaaa tctgaataat     4920

tttgtgttac tcatagcgcg taatactgta atagtaatca attacggggt cattagttca     4980

tagcccatat atggagttcc gcgttacata acttacggta aatggcccgc ctggctgacc     5040

gcccaacgac ccccgcccat tgacgtcaat aatgacgtat gttcccatag taacgccaat     5100

agggactttc cattgacgtc aatgggtgga gtatttacgg taaactgccc acttggcagt     5160

acatcaagtg tatcatatgc caagtacgcc ccctattgac gtcaatgacg gtaaatggcc     5220

cgcctggcat tatgcccagt acatgacctt atgggacttt cctacttggc agtacatcta     5280

cgtattagtc atcgctatta ccatggtgat gcggttttgg cagtacatca atgggcgtgg     5340

atagcggttt gactcacggg gatttccaag tctccacccc attgacgtca atgggagttt     5400

gttttggcac caaaatcaac gggactttcc aaaatgtcgt aacaactccg ccccattgac     5460

gcaaatgggc ggtaggcgtg tacggtggga ggtctatata agcagagctg gtttagtgaa     5520

ccgtcagatc cgctagagat ctggtaccgt cgacgcggcc gctcgagcct aagcttatga     5580

gcagcagtag ttggcttctc ttgagtttgg tggcagtgac agcagcccag agtactatcg     5640

aggagcaggc taaatacttt ctggataagt ttaacgccga ggccgaagac ttgttctatc     5700

aatcttctct cgcttcatgg aattacaata ctaacatcac tgaggagaac gtccagaata     5760

tgaacaatgc tggcgacaaa tggagcgcct tcttgaagga gcagtctacc cttgcacaaa     5820

tgtatccact gcaggagata cagaacctta cagtaaagtt gcagctccag gctctccagc     5880

agaacggatc tagcgtgctt tcagaggata aaagcaaaag gctgaacacc atacttaata     5940

ccatgtccac aatttactct actggtaaag tatgtaaccc cgacaaccct caagaatgcc     6000

tccttcttga gccaggcctc aatgagatca tggctaatag tctggactat aatgaaagac     6060

tgtgggcatg ggagtcctgg agatctgaag tagggaagca actgaggccc ctttatgaag     6120

agtacgtcgt acttaagaat gaaatggccc gcgctaacca ctacgaggat tacggcgatt     6180

actggcgtgg ggactatgaa gtaaatggtg tagatggata cgactatagt cgtgggcaat     6240

tgattgagga tgtggagcac acttttgagg agataaaacc actctatgag catcttcacg     6300

catatgtgag agctaaactg atgaacgcct acccaagtta catcagtcca atcggatgtc     6360

tcccagctca cctccttggc gacatgtggg gacgtttctg gaccaatctg tattccctca     6420

cagtcccttt cgggcaaaag cctaatatag acgtgacaga cgcaatggtt gatcaggctt     6480

gggatgctca aaggattttt aaggaagctg agaagttttt tgtgtcagtc ggtttgccaa     6540

atatgacaca aggcttctgg gaaaatagca tgttgactga tcccggtaat gttcaaaagg     6600

ctgtgtgtca ccctaccgct tgggaccttg ggaaaggtga ctttcgaatc ttgatgtgta     6660

ccaaggtgac aatggatgac tttcttacag cccatcatga aatgggtaat atccagtatg     6720

atatggctta tgcagctcaa cctttcctct tgagaaatgg tgcaaatgaa ggttttcatg     6780

aagctgtagg ggaaataatg tccctgagtg ctgcaacccc aaagcatctc aagagtatcg     6840

gattgttgag cccagatttt caagaagata acgagaccga aatcaacttc cttctgaaac     6900

aagccctcac aatagttggt actcttccat tcacatacat gctggagaaa tggcgttgga     6960

tggtttttaa gggggagata cctaaagatc agtggatgaa aaagtggtgg gagatgaagc     7020

gtgagatcgt aggggtcgtg gagccagtgc ctcatgatga gacttactgt gacccagcat     7080

cactcttcca cgttagcaat gactattcat ttatacgtta ttacactcgc actctttacc     7140

agtttcaatt tcaggaggct ctgtgtcagg ctgccaagca tgagggaccc cttcacaagt     7200

gtgatattag taacagtact gaggcaggcc aaaaactgtt caatatgttg aggcttggca     7260

aaagcgagcc atggactctc gccttggaaa atgttgtcgg ggctaaaaac atgaatgtac     7320

gccctctgct taactatttt gagccccttt ttacatggct caaggaccag aataagaact     7380

cctttgtcgg ctggtcaaca gactggtctc cctatgcaga ccctagtact cctcctactc     7440

cttctccatc aaccccacca actccatccc ctagctgctg tcacccaagg ctgtctctgc     7500

accgacctgc actcgaagac cttctgttgg gctctgaagc taacctgacc tgtactctta     7560

ctggcttgcg cgatgctagc ggcgtgactt tcacctggac acctagtagc ggtaaaagtg     7620

ctgtacaagg acctcctgaa cgcgacctgt gtggttgcta ctctgtgtct tctgtacttc     7680

ccggctgtgc cgagccctgg aatcacggga aaacctttac ctgcaccgcc gcttaccctg     7740

agtcaaaaac tcccctcact gccacattga gtaagtcagg gaatacattc aggccagagg     7800

ttcatttgtt gcctcctcca tctgaagaac ttgctttgaa cgagctggtc actctgacct     7860

gcttggctag gggtttctcc cccaaagatg tacttgtacg gtggttgcag ggcagccaag     7920

agttgccccg cgaaaagtat ttgacctggg cctcaagaca agaacccagc caggggacta     7980

ccacatttgc cgtgaccagt attctgcgtg tagccgctga agattggaag aaaggggata     8040

cattttcttg catggtaggg catgaggccc ttcccctcgc tttcactcag aagacaatag     8100

acagactcgc cggaaagcct actcacgtga atgttagcgt agtcatggct gaggttgacg     8160

gaacttgcta ctgagatatc cgatccaccg gatctagata actgatcata atcagccata     8220

ccacatttgt agaggtttta cttgctttaa aaaacctccc acacctcccc ctgaacctga     8280

aacataaaat gaatgcaatt gttgttgtta acttgtttat tgcagcttat aatggttaca     8340

aataaagcaa tagcatcaca aatttcacaa ataaagcatt tttttcactg cattctagtt     8400

gtggtttgtc caaactcatc aatgtatctt aggtttagtg aaccgtcaga tccgctagcg     8460

ttacataact tacggtaaat ggcccgcctg gctgaccgcc caacgacccc cgcccattga     8520

cgtcaataat gacgtatgtt cccatagtaa cgccaatagg gactttccat tgacgtcaat     8580

gggtggagta tttacggtaa actgcccact tggcagtaca tcaagtgtat catatgccaa     8640

gtacgccccc tattgacgtc aatgacggta aatggcccgc ctggcattat gcccagtaca     8700

tgaccttatg ggactttcct acttggcagt acatctacgt attagtcatc gctattacca     8760

tggtgatgcg gttttggcag tacatcaatg ggcgtggata gcggtttgac tcacggggat     8820

ttccaagtct ccaccccatt gacgtcaatg ggagtttgtt ttggcaccaa aatcaacggg     8880

actttccaaa atgtcgtaac aactccgccc cattgacgca aatgggcggt aggcgtgtac     8940

ggtgggaggt ctatataagc agagctggtt tagtgaaccg tcagatccgc tagagatctg     9000

gtaccgtcga cgcggccgct cgagcctaag cttatgaaga accatctgct tttctgggga     9060

gtacttgccg ttttcataaa agccgtacat gttaaagcac aagaggacga acgcattgtg     9120

ttggttgata ataaatgcaa atgtgctcgg ataacatctc ggatcattcg tagctcagag     9180

gaccccaatg aggatatagt agagcgaaac atcagaatta tagtacccct gaacaacaga     9240

gagaacataa gtgatcccac aagtccattg cggacacgct ttgtttacca tttgtctgat     9300

ctgtgtaaaa aatgtgatcc aacagaggtg gaactcgaca atcagatcgt caccgccacc     9360

cagtctaaca tctgcgatga agattcagct acagagacat gctacacata cgaccggaac     9420

aagtgctata ctgccgttgt gccactcgtt tacggtggag aaacaaagat ggttgaaact     9480

gcacttacac cagatgcctg ctatccagat tgagatatcc gatccaccgg atctagataa     9540

ctgatcataa tcagccatac cacatttgta gaggttttac ttgctttaaa aaacctccca     9600

cacctccccc tgaacctgaa acataaaatg aatgcaattg ttgttgttaa cttgtttatt     9660

gcagcttata atggttacaa ataaagcaat agcatcacaa atttcacaaa taaagcattt     9720

ttttcactgc attctagttg tggtttgtcc aaactcatca atgtatctta acgcggatct     9780

gggcgtggtt aagggtggga aagaatatat aaggtggggg tcttatgtag ttttgtatct     9840

gttttgcagc agccgccgcc gccatgagca ccaactcgtt tgatggaagc attgtgagct     9900

catatttgac aacgcgcatg cccccatggg ccggggtgcg tcagaatgtg atgggctcca     9960

gcattgatgg tcgccccgtc ctgcccgcaa actctactac cttgacctac gagaccgtgt    10020

ctggaacgcc gttggagact gcagcctccg ccgccgcttc agccgctgca gccaccgccc    10080

gcgggattgt gactgacttt gctttcctga gcccgcttgc aagcagtgca gcttcccgtt    10140

catccgcccg cgatgacaag ttgacggctc ttttggcaca attggattct ttgacccggg    10200

aacttaatgt cgtttctcag cagctgttgg atctgcgcca gcaggtttct gccctgaagg    10260

cttcctcccc tcccaatgcg gtttaaaaca taaataaaaa accagactct gtttggattt    10320

ggatcaagca agtgtcttgc tgtctttatt taggggtttt gcgcgcgcgg taggcccggg    10380

accagcggtc tcggtcgttg agggtcctgt gtattttttc caggacgtgg taaaggtgac    10440

tctggatgtt cagatacatg ggcataagcc cgtctctggg gtggaggtag caccactgca    10500

gagcttcatg ctgcggggtg gtgttgtaga tgatccagtc gtagcaggag cgctgggcgt    10560

ggtgcctaaa aatgtctttc agtagcaagc tgattgccag gggcaggccc ttggtgtaag    10620

tgtttacaaa gcggttaagc tgggatgggt gcatacgtgg ggatatgaga tgcatcttgg    10680

actgtatttt taggttggct atgttcccag ccatatccct ccggggattc atgttgtgca    10740

gaaccaccag cacagtgtat ccggtgcact tgggaaattt gtcatgtagc ttagaaggaa    10800

atgcgtggaa gaacttggag acgcccttgt gacctccaag attttccatg cattcgtcca    10860

taatgatggc aatgggccca cgggcggcgg cctgggcgaa gatatttctg ggatcactaa    10920

cgtcatagtt gtgttccagg atgagatcgt cataggccat ttttacaaag cgcgggcgga    10980

gggtgccaga ctgcggtata atggttccat ccggcccagg ggcgtagtta ccctcacaga    11040

tttgcatttc ccacgctttg agttcagatg gggggatcat gtctacctgc ggggcgatga    11100

agaaaacggt ttccggggta ggggagatca gctgggaaga aagcaggttc ctgagcagct    11160

gcgacttacc gcagccggtg ggcccgtaaa tcacacctat taccggctgc aactggtagt    11220

taagagagct gcagctgccg tcatccctga gcaggggggc cacttcgtta agcatgtccc    11280

tgactcgcat gttttccctg accaaatccg ccagaaggcg ctcgccgccc agcgatagca    11340

gttcttgcaa ggaagcaaag tttttcaacg gtttgagacc gtccgccgta ggcatgcttt    11400

tgagcgtttg accaagcagt tccaggcggt cccacagctc ggtcacctgc tctacggcat    11460

ctcgatccag catatctcct cgtttcgcgg gttggggcgg ctttcgctgt acggcagtag    11520

tcggtgctcg tccagacggg ccagggtcat gtctttccac gggcgcaggg tcctcgtcag    11580

cgtagtctgg gtcacggtga aggggtgcgc tccgggctgc gcgctggcca gggtgcgctt    11640

gaggctggtc ctgctggtgc tgaagcgctg ccggtcttcg ccctgcgcgt cggccaggta    11700

gcatttgacc atggtgtcat agtccagccc ctccgcggcg tggcccttgg cgcgcagctt    11760

gcccttggag gaggcgccgc acgaggggca gtgcagactt ttgagggcgt agagcttggg    11820

cgcgagaaat accgattccg gggagtaggc atccgcgccg caggccccgc agacggtctc    11880

gcattccacg agccaggtga gctctggccg ttcggggtca aaaaccaggt ttcccccatg    11940

ctttttgatg cgtttcttac ctctggtttc catgagccgg tgtccacgct cggtgacgaa    12000

aaggctgtcc gtgtccccgt atacagactt gagaggcctg tcctcgagcg gtgttccgcg    12060

gtcctcctcg tatagaaact cggaccactc tgagacaaag gctcgcgtcc aggccagcac    12120

gaaggaggct aagtgggagg ggtagcggtc gttgtccact agggggtcca ctcgctccag    12180

ggtgtgaaga cacatgtcgc cctcttcggc atcaaggaag gtgattggtt tgtaggtgta    12240

ggccacgtga ccgggtgttc ctgaaggggg gctataaaag ggggtggggg cgcgttcgtc    12300

ctcactctct tccgcatcgc tgtctgcgag ggccagctgt tggggtgagt actccctctg    12360

aaaagcgggc atgacttctg cgctaagatt gtcagtttcc aaaaacgagg aggatttgat    12420

attcacctgg cccgcggtga tgcctttgag ggtggccgca tccatctggt cagaaaagac    12480

aatctttttg ttgtcaagct tggtggcaaa cgacccgtag agggcgttgg acagcaactt    12540

ggcgatggag cgcagggttt ggtttttgtc gcgatcggcg cgctccttgg ccgcgatgtt    12600

tagctgcacg tattcgcgcg caacgcaccg ccattcggga aagacggtgg tgcgctcgtc    12660

gggcaccagg tgcacgcgcc aaccgcggtt gtgcagggtg acaaggtcaa cgctggtggc    12720

tacctctccg cgtaggcgct cgttggtcca gcagaggcgg ccgcccttgc gcgagcagaa    12780

tggcggtagg gggtctagct gcgtctcgtc cggggggtct gcgtccacgg taaagacccc    12840

gggcagcagg cgcgcgtcga agtagtctat cttgcatcct tgcaagtcta gcgcctgctg    12900

ccatgcgcgg gcggcaagcg cgcgctcgta tgggttgagt gggggacccc atggcatggg    12960

gtgggtgagc gcggaggcgt acatgccgca aatgtcgtaa acgtagaggg gctctctgag    13020

tattccaaga tatgtagggt agcatcttcc accgcggatg ctggcgcgca cgtaatcgta    13080

tagttcgtgc gagggagcga ggaggtcggg accgaggttg ctacgggcgg gctgctctgc    13140

tcggaagact atctgcctga agatggcatg tgagttggat gatatggttg gacgctggaa    13200

gacgttgaag ctggcgtctg tgagacctac cgcgtcacgc acgaaggagg cgtaggagtc    13260

gcgcagcttg ttgaccagct cggcggtgac ctgcacgtct agggcgcagt agtccagggt    13320

ttccttgatg atgtcatact tatcctgtcc cttttttttc cacagctcgc ggttgaggac    13380

aaactcttcg cggtctttcc agtactcttg gatcggaaac ccgtcggcct ccgaacggta    13440

agagcctagc atgtagaact ggttgacggc ctggtaggcg cagcatccct tttctacggg    13500

tagcgcgtat gcctgcgcgg ccttccggca tgaccagcat gaagggcacg agctgcttcc    13560

caaaggcccc catccaagta taggtctcta catcgtaggt gacaaagaga cgctcggtgc    13620

gaggatgcga gccgatcggg aagaactgga tctcccgcca ccaattggag gagtggctat    13680

tgatgtggtg aaagtagaag tccctgcgac gggccgaaca ctcgtgctgg cttttgtaaa    13740

aacgtgcgca gtactggcag cggtgcacgg gctgtacatc ctgcacgagg ttgacctgac    13800

gaccgcgcac aaggaagcag agtgggaatt tgagcccctc gcctggcggg tttggctggt    13860

ggtcttctac ttcggctgct tgtccttgac cgtctggctg ctcgagggga gttacggtgg    13920

atcggaccac cacgccgcgc gagcccaaag tccagatgtc cgcgcgcggc ggtcggagct    13980

tgatgacaac atcgcgcaga tgggagctgt ccatggtctg gagctcccgc ggcgtcaggt    14040

caggcgggag ctcctgcagg tttacctcgc atagacgggt cagggcgcgg gctagatcca    14100

ggtgatacct aatttccagg ggctggttgg tggcggcgtc gatggcttgc aagaggccgc    14160

atccccgcgg cgcgactacg gtaccgcgcg gcgggcggtg ggccgcgggg gtgtccttgg    14220

atgatgcatc taaaagcggt gacgcgggcg agcccccgga ggtagggggg gctccggacc    14280

cgccgggaga gggggcaggg gcacgtcggc gccgcgcgcg ggcaggagct ggtgctgcgc    14340

gcgtaggttg ctggcgaacg cgacgacgcg gcggttgatc tcctgaatct ggcgcctctg    14400

cgtgaagacg acgggcccgg tgagcttgaa cctgaaagag agttcgacag aatcaatttc    14460

ggtgtcgttg acggcggcct ggcgcaaaat ctcctgcacg tctcctgagt tgtcttgata    14520

ggcgatctcg gccatgaact gctcgatctc ttcctcctgg agatctccgc gtccggctcg    14580

ctccacggtg gcggcgaggt cgttggaaat gcgggccatg agctgcgaga aggcgttgag    14640

gcctccctcg ttccagacgc ggctgtagac cacgccccct tcggcatcgc gggcgcgcat    14700

gaccacctgc gcgagattga gctccacgtg ccgggcgaag acggcgtagt ttcgcaggcg    14760

ctgaaagagg tagttgaggg tggtggcggt gtgttctgcc acgaagaagt acataaccca    14820

gcgtcgcaac gtggattcgt tgataattgt tgtgtaggta ctccgccgcc gagggacctg    14880

agcgagtccg catcgaccgg atcggaaaac ctctcgagaa aggcgtctaa ccagtcacag    14940

tcgcaaggta ggctgagcac cgtggcgggc ggcagcgggc ggcggtcggg gttgtttctg    15000

gcggaggtgc tgctgatgat gtaattaaag taggcggtct tgagacggcg gatggtcgac    15060

agaagcacca tgtccttggg tccggcctgc tgaatgcgca ggcggtcggc catgccccag    15120

gcttcgtttt gacatcggcg caggtctttg tagtagtctt gcatgagcct ttctaccggc    15180

acttcttctt ctccttcctc ttgtcctgca tctcttgcat ctatcgctgc ggcggcggcg    15240

gagtttggcc gtaggtggcg ccctcttcct cccatgcgtg tgaccccgaa gcccctcatc    15300

ggctgaagca gggctaggtc ggcgacaacg cgctcggcta atatggcctg ctgcacctgc    15360

gtgagggtag actggaagtc atccatgtcc acaaagcggt ggtatgcgcc cgtgttgatg    15420

gtgtaagtgc agttggccat aacggaccag ttaacggtct ggtgacccgg ctgcgagagc    15480

tcggtgtacc tgagacgcga gtaagccctc gagtcaaata cgtagtcgtt gcaagtccgc    15540

accaggtact ggtatcccac caaaaagtgc ggcggcggct ggcggtagag gggccagcgt    15600

agggtggccg gggctccggg ggcgagatct tccaacataa ggcgatgata tccgtagatg    15660

tacctggaca tccaggtgat gccggcggcg gtggtggagg cgcgcggaaa gtcgcggacg    15720

cggttccaga tgttgcgcag cggcaaaaag tgctccatgg tcgggacgct ctggccggtc    15780

aggcgcgcgc aatcgttgac gctctagcgt gcaaaaggag agcctgtaag cgggcactct    15840

tccgtggtct ggtggataaa ttcgcaaggg tatcatggcg gacgaccggg gttcgagccc    15900

cgtatccggc cgtccgccgt gatccatgcg gttaccgccc gcgtgtcgaa cccaggtgtg    15960

cgacgtcaga caacggggga gtgctccttt tggcttcctt ccaggcgcgg cggctgctgc    16020

gctagctttt ttggccactg gccgcgcgca gcgtaagcgg ttaggctgga aagcgaaagc    16080

attaagtggc tcgctccctg tagccggagg gttattttcc aagggttgag tcgcgggacc    16140

cccggttcga gtctcggacc ggccggactg cggcgaacgg gggtttgcct ccccgtcatg    16200

caagaccccg cttgcaaatt cctccggaaa cagggacgag cccctttttt gcttttccca    16260

gatgcatccg gtgctgcggc agatgcgccc ccctcctcag cagcggcaag agcaagagca    16320

gcggcagaca tgcagggcac cctcccctcc tcctaccgcg tcaggagggg cgacatccgc    16380

ggttgacgcg gcagcagatg gtgattacga acccccgcgg cgccgggccc ggcactacct    16440

ggacttggag gagggcgagg gcctggcgcg gctaggagcg ccctctcctg agcggcaccc    16500

aagggtgcag ctgaagcgtg atacgcgtga ggcgtacgtg ccgcggcaga acctgtttcg    16560

cgaccgcgag ggagaggagc ccgaggagat gcgggatcga aagttccacg cagggcgcga    16620

gctgcggcat ggcctgaatc gcgagcggtt gctgcgcgag gaggactttg agcccgacgc    16680

gcgaaccggg attagtcccg cgcgcgcaca cgtggcggcc gccgacctgg taaccgcata    16740

cgagcagacg gtgaaccagg agattaactt tcaaaaaagc tttaacaacc acgtgcgtac    16800

gcttgtggcg cgcgaggagg tggctatagg actgatgcat ctgtgggact ttgtaagcgc    16860

gctggagcaa aacccaaata gcaagccgct catggcgcag ctgttcctta tagtgcagca    16920

cagcagggac aacgaggcat tcagggatgc gctgctaaac atagtagagc ccgagggccg    16980

ctggctgctc gatttgataa acatcctgca gagcatagtg gtgcaggagc gcagcttgag    17040

cctggctgac aaggtggccg ccatcaacta ttccatgctt agcctgggca agttttacgc    17100

ccgcaagata taccataccc cttacgttcc catagacaag gaggtaaaga tcgaggggtt    17160

ctacatgcgc atggcgctga aggtgcttac cttgagcgac gacctgggcg tttatcgcaa    17220

cgagcgcatc cacaaggccg tgagcgtgag ccggcggcgc gagctcagcg accgcgagct    17280

gatgcacagc ctgcaaaggg ccctggctgg cacgggcagc ggcgatagag aggccgagtc    17340

ctactttgac gcgggcgctg acctgcgctg ggccccaagc cgacgcgccc tggaggcagc    17400

tggggccgga cctgggctgg cggtggcacc cgcgcgcgct ggcaacgtcg gcggcgtgga    17460

ggaatatgac gaggacgatg agtacgagcc agaggacggc gagtactaag cggtgatgtt    17520

tctgatcaga tgatgcaaga cgcaacggac ccggcggtgc gggcggcgct gcagagccag    17580

ccgtccggcc ttaactccac ggacgactgg cgccaggtca tggaccgcat catgtcgctg    17640

actgcgcgca atcctgacgc gttccggcag cagccgcagg ccaaccggct ctccgcaatt    17700

ctggaagcgg tggtcccggc gcgcgcaaac cccacgcacg agaaggtgct ggcgatcgta    17760

aacgcgctgg ccgaaaacag ggccatccgg cccgacgagg ccggcctggt ctacgacgcg    17820

ctgcttcagc gcgtggctcg ttacaacagc ggcaacgtgc agaccaacct ggaccggctg    17880

gtgggggatg tgcgcgaggc cgtggcgcag cgtgagcgcg cgcagcagca gggcaacctg    17940

ggctccatgg ttgcactaaa cgccttcctg agtacacagc ccgccaacgt gccgcgggga    18000

caggaggact acaccaactt tgtgagcgca ctgcggctaa tggtgactga gacaccgcaa    18060

agtgaggtgt accagtctgg gccagactat tttttccaga ccagtagaca aggcctgcag    18120

accgtaaacc tgagccaggc tttcaaaaac ttgcaggggc tgtggggggt gcgggctccc    18180

acaggcgacc gcgcgaccgt gtctagcttg ctgacgccca actcgcgcct gttgctgctg    18240

ctaatagcgc ccttcacgga cagtggcagc gtgtcccggg acacatacct aggtcacttg    18300

ctgacactgt accgcgaggc cataggtcag gcgcatgtgg acgagcatac tttccaggag    18360

attacaagtg tcagccgcgc gctggggcag gaggacacgg gcagcctgga ggcaacccta    18420

aactacctgc tgaccaaccg gcggcagaag atcccctcgt tgcacagttt aaacagcgag    18480

gaggagcgca ttttgcgcta cgtgcagcag agcgtgagcc ttaacctgat gcgcgacggg    18540

gtaacgccca gcgtggcgct ggacatgacc gcgcgcaaca tggaaccggg catgtatgcc    18600

tcaaaccggc cgtttatcaa ccgcctaatg gactacttgc atcgcgcggc cgccgtgaac    18660

cccgagtatt tcaccaatgc catcttgaac ccgcactggc taccgccccc tggtttctac    18720

accgggggat tcgaggtgcc cgagggtaac gatggattcc tctgggacga catagacgac    18780

agcgtgtttt ccccgcaacc gcagaccctg ctagagttgc aacagcgcga gcaggcagag    18840

gcggcgctgc gaaaggaaag cttccgcagg ccaagcagct tgtccgatct aggcgctgcg    18900

gccccgcggt cagatgctag tagcccattt ccaagcttga tagggtctct taccagcact    18960

cgcaccaccc gcccgcgcct gctgggcgag gaggagtacc taaacaactc gctgctgcag    19020

ccgcagcgcg aaaaaaacct gcctccggca tttcccaaca acgggataga gagcctagtg    19080

gacaagatga gtagatggaa gacgtacgcg caggagcaca gggacgtgcc aggcccgcgc    19140

ccgcccaccc gtcgtcaaag gcacgaccgt cagcggggtc tggtgtggga ggacgatgac    19200

tcggcagacg acagcagcgt cctggatttg ggagggagtg gcaacccgtt tgcgcacctt    19260

cgccccaggc tggggagaat gttttaaaaa aaaaaaagca tgatgcaaaa taaaaaactc    19320

accaaggcca tggcaccgag cgttggtttt cttgtattcc ccttagtatg cggcgcgcgg    19380

cgatgtatga ggaaggtcct cctccctcct acgagagtgt ggtgagcgcg gcgccagtgg    19440

cggcggcgct gggttctccc ttcgatgctc ccctggaccc gccgtttgtg cctccgcggt    19500

acctgcggcc taccgggggg agaaacagca tccgttactc tgagttggca cccctattcg    19560

acaccacccg tgtgtacctg gtggacaaca agtcaacgga tgtggcatcc ctgaactacc    19620

agaacgacca cagcaacttt ctgaccacgg tcattcaaaa caatgactac agcccggggg    19680

aggcaagcac acagaccatc aatcttgacg accggtcgca ctggggcggc gacctgaaaa    19740

ccatcctgca taccaacatg ccaaatgtga acgagttcat gtttaccaat aagtttaagg    19800

cgcgggtgat ggtgtcgcgc ttgcctacta aggacaatca ggtggagctg aaatacgagt    19860

gggtggagtt cacgctgccc gagggcaact actccgagac catgaccata gaccttatga    19920

acaacgcgat cgtggagcac tacttgaaag tgggcagaca gaacggggtt ctggaaagcg    19980

acatcggggt aaagtttgac acccgcaact tcagactggg gtttgacccc gtcactggtc    20040

ttgtcatgcc tggggtatat acaaacgaag ccttccatcc agacatcatt ttgctgccag    20100

gatgcggggt ggacttcacc cacagccgcc tgagcaactt gttgggcatc cgcaagcggc    20160

aacccttcca ggagggcttt aggatcacct acgatgatct ggagggtggt aacattcccg    20220

cactgttgga tgtggacgcc taccaggcga gcttgaaaga tgacaccgaa cagggcgggg    20280

gtggcgcagg cggcagcaac agcagtggca gcggcgcgga agagaactcc aacgcggcag    20340

ccgcggcaat gcagccggtg gaggacatga acgatcatgc cattcgcggc gacacctttg    20400

ccacacgggc tgaggagaag cgcgctgagg ccgaagcagc ggccgaagct gccgcccccg    20460

ctgcgcaacc cgaggtcgag aagcctcaga agaaaccggt gatcaaaccc ctgacagagg    20520

acagcaagaa acgcagttac aacctaataa gcaatgacag caccttcacc cagtaccgca    20580

gctggtacct tgcatacaac tacggcgacc ctcagaccgg aatccgctca tggaccctgc    20640

tttgcactcc tgacgtaacc tgcggctcgg agcaggtcta ctggtcgttg ccagacatga    20700

tgcaagaccc cgtgaccttc cgctccacgc gccagatcag caactttccg gtggtgggcg    20760

ccgagctgtt gcccgtgcac tccaagagct tctacaacga ccaggccgtc tactcccaac    20820

tcatccgcca gtttacctct ctgacccacg tgttcaatcg ctttcccgag aaccagattt    20880

tggcgcgccc gccagccccc accatcacca ccgtcagtga aaacgttcct gctctcacag    20940

atcacgggac gctaccgctg cgcaacagca tcggaggagt ccagcgagtg accattactg    21000

acgccagacg ccgcacctgc ccctacgttt acaaggccct gggcatagtc tcgccgcgcg    21060

tcctatcgag ccgcactttt tgagcaagca tgtccatcct tatatcgccc agcaataaca    21120

caggctgggg cctgcgcttc ccaagcaaga tgtttggcgg ggccaagaag cgctccgacc    21180

aacacccagt gcgcgtgcgc gggcactacc gcgcgccctg gggcgcgcac aaacgcggcc    21240

gcactgggcg caccaccgtc gatgacgcca tcgacgcggt ggtggaggag gcgcgcaact    21300

acacgcccac gccgccacca gtgtccacag tggacgcggc cattcagacc gtggtgcgcg    21360

gagcccggcg ctatgctaaa atgaagagac ggcggaggcg cgtagcacgt cgccaccgcc    21420

gccgacccgg cactgccgcc caacgcgcgg cggcggccct gcttaaccgc gcacgtcgca    21480

ccggccgacg ggcggccatg cgggccgctc gaaggctggc cgcgggtatt gtcactgtgc    21540

cccccaggtc caggcgacga gcggccgccg cagcagccgc ggccattagt gctatgactc    21600

agggtcgcag gggcaacgtg tattgggtgc gcgactcggt tagcggcctg cgcgtgcccg    21660

tgcgcacccg ccccccgcgc aactagattg caagaaaaaa ctacttagac tcgtactgtt    21720

gtatgtatcc agcggcggcg gcgcgcaacg aagctatgtc caagcgcaaa atcaaagaag    21780

agatgctcca ggtcatcgcg ccggagatct atggcccccc gaagaaggaa gagcaggatt    21840

acaagccccg aaagctaaag cgggtcaaaa agaaaaagaa agatgatgat gatgaacttg    21900

acgacgaggt ggaactgctg cacgctaccg cgcccaggcg acgggtacag tggaaaggtc    21960

gacgcgtaaa acgtgttttg cgacccggca ccaccgtagt ctttacgccc ggtgagcgct    22020

ccacccgcac ctacaagcgc gtgtatgatg aggtgtacgg cgacgaggac ctgcttgagc    22080

aggccaacga gcgcctcggg gagtttgcct acggaaagcg gcataaggac atgctggcgt    22140

tgccgctgga cgagggcaac ccaacaccta gcctaaagcc cgtaacactg cagcaggtgc    22200

tgcccgcgct tgcaccgtcc gaagaaaagc gcggcctaaa gcgcgagtct ggtgacttgg    22260

cacccaccgt gcagctgatg gtacccaagc gccagcgact ggaagatgtc ttggaaaaaa    22320

tgaccgtgga acctgggctg gagcccgagg tccgcgtgcg gccaatcaag caggtggcgc    22380

cgggactggg cgtgcagacc gtggacgttc agatacccac taccagtagc accagtattg    22440

ccaccgccac agagggcatg gagacacaaa cgtccccggt tgcctcagcg gtggcggatg    22500

ccgcggtgca ggcggtcgct gcggccgcgt ccaagacctc tacggaggtg caaacggacc    22560

cgtggatgtt tcgcgtttca gccccccggc gcccgcgccg ttcgaggaag tacggcgccg    22620

ccagcgcgct actgcccgaa tatgccctac atccttccat tgcgcctacc cccggctatc    22680

gtggctacac ctaccgcccc agaagacgag caactacccg acgccgaacc accactggaa    22740

cccgccgccg ccgtcgccgt cgccagcccg tgctggcccc gatttccgtg cgcagggtgg    22800

ctcgcgaagg aggcaggacc ctggtgctgc caacagcgcg ctaccacccc agcatcgttt    22860

aaaagccggt ctttgtggtt cttgcagata tggccctcac ctgccgcctc cgtttcccgg    22920

tgccgggatt ccgaggaaga atgcaccgta ggaggggcat ggccggccac ggcctgacgg    22980

gcggcatgcg tcgtgcgcac caccggcggc ggcgcgcgtc gcaccgtcgc atgcgcggcg    23040

gtatcctgcc cctccttatt ccactgatcg ccgcggcgat tggcgccgtg cccggaattg    23100

catccgtggc cttgcaggcg cagagacact gattaaaaac aagttgcatg tggaaaaatc    23160

aaaataaaaa gtctggactc tcacgctcgc ttggtcctgt aactattttg tagaatggaa    23220

gacatcaact ttgcgtctct ggccccgcga cacggctcgc gcccgttcat gggaaactgg    23280

caagatatcg gcaccagcaa tatgagcggt ggcgccttca gctggggctc gctgtggagc    23340

ggcattaaaa atttcggttc caccgttaag aactatggca gcaaggcctg gaacagcagc    23400

acaggccaga tgctgaggga taagttgaaa gagcaaaatt tccaacaaaa ggtggtagat    23460

ggcctggcct ctggcattag cggggtggtg gacctggcca accaggcagt gcaaaataag    23520

attaacagta agcttgatcc ccgccctccc gtagaggagc ctccaccggc cgtggagaca    23580

gtgtctccag aggggcgtgg cgaaaagcgt ccgcgccccg acagggaaga aactctggtg    23640

acgcaaatag acgagcctcc ctcgtacgag gaggcactaa agcaaggcct gcccaccacc    23700

cgtcccatcg cgcccatggc taccggagtg ctgggccagc acacacccgt aacgctggac    23760

ctgcctcccc ccgccgacac ccagcagaaa cctgtgctgc caggcccgac cgccgttgtt    23820

gtaacccgtc ctagccgcgc gtccctgcgc cgcgccgcca gcggtccgcg atcgttgcgg    23880

cccgtagcca gtggcaactg gcaaagcaca ctgaacagca tcgtgggtct gggggtgcaa    23940

tccctgaagc gccgacgatg cttctgatag ctaacgtgtc gtatgtgtgt catgtatgcg    24000

tccatgtcgc cgccagagga gctgctgagc cgccgcgcgc ccgctttcca agatggctac    24060

cccttcgatg atgccgcagt ggtcttacat gcacatctcg ggccaggacg cctcggagta    24120

cctgagcccc gggctggtgc agtttgcccg cgccaccgag acgtacttca gcctgaataa    24180

caagtttaga aaccccacgg tggcgcctac gcacgacgtg accacagacc ggtcccagcg    24240

tttgacgctg cggttcatcc ctgtggaccg tgaggatact gcgtactcgt acaaggcgcg    24300

gttcacccta gctgtgggtg ataaccgtgt gctggacatg gcttccacgt actttgacat    24360

ccgcggcgtg ctggacaggg gccctacttt taagccctac tctggcactg cctacaacgc    24420

cctggctccc aagggtgccc caaatccttg cgaatgggat gaagctgcta ctgctcttga    24480

aataaaccta gaagaagagg acgatgacaa cgaagacgaa gtagacgagc aagctgagca    24540

gcaaaaaact cacgtatttg ggcaggcgcc ttattctggt ataaatatta caaaggaggg    24600

tattcaaata ggtgtcgaag gtcaaacacc taaatatgcc gataaaacat ttcaacctga    24660

acctcaaata ggagaatctc agtggtacga aacagaaatt aatcatgcag ctgggagagt    24720

cctaaaaaag actaccccaa tgaaaccatg ttacggttca tatgcaaaac ccacaaatga    24780

aaatggaggg caaggcattc ttgtaaagca acaaaatgga aagctagaaa gtcaagtgga    24840

aatgcaattt ttctcaacta ctgaggcagc cgcaggcaat ggtgataact tgactcctaa    24900

agtggtattg tacagtgaag atgtagatat agaaacccca gacactcata tttcttacat    24960

gcccactatt aaggaaggta actcacgaga actaatgggc caacaatcta tgcccaacag    25020

gcctaattac attgctttta gggacaattt tattggtcta atgtattaca acagcacggg    25080

taatatgggt gttctggcgg gccaagcatc gcagttgaat gctgttgtag atttgcaaga    25140

cagaaacaca gagctttcat accagctttt gcttgattcc attggtgata gaaccaggta    25200

cttttctatg tggaatcagg ctgttgacag ctatgatcca gatgttagaa ttattgaaaa    25260

tcatggaact gaagatgaac ttccaaatta ctgctttcca ctgggaggtg tgattaatac    25320

agagactctt accaaggtaa aacctaaaac aggtcaggaa aatggatggg aaaaagatgc    25380

tacagaattt tcagataaaa atgaaataag agttggaaat aattttgcca tggaaatcaa    25440

tctaaatgcc aacctgtgga gaaatttcct gtactccaac atagcgctgt atttgcccga    25500

caagctaaag tacagtcctt ccaacgtaaa aatttctgat aacccaaaca cctacgacta    25560

catgaacaag cgagtggtgg ctcccgggct agtggactgc tacattaacc ttggagcacg    25620

ctggtccctt gactatatgg acaacgtcaa cccatttaac caccaccgca atgctggcct    25680

gcgctaccgc tcaatgttgc tgggcaatgg tcgctatgtg cccttccaca tccaggtgcc    25740

tcagaagttc tttgccatta aaaacctcct tctcctgccg ggctcataca cctacgagtg    25800

gaacttcagg aaggatgtta acatggttct gcagagctcc ctaggaaatg acctaagggt    25860

tgacggagcc agcattaagt ttgatagcat ttgcctttac gccaccttct tccccatggc    25920

ccacaacacc gcctccacgc ttgaggccat gcttagaaac gacaccaacg accagtcctt    25980

taacgactat ctctccgccg ccaacatgct ctaccctata cccgccaacg ctaccaacgt    26040

gcccatatcc atcccctccc gcaactgggc ggctttccgc ggctgggcct tcacgcgcct    26100

taagactaag gaaaccccat cactgggctc gggctacgac ccttattaca cctactctgg    26160

ctctataccc tacctagatg gaacctttta cctcaaccac acctttaaga aggtggccat    26220

tacctttgac tcttctgtca gctggcctgg caatgaccgc ctgcttaccc ccaacgagtt    26280

tgaaattaag cgctcagttg acggggaggg ttacaacgtt gcccagtgta acatgaccaa    26340

agactggttc ctggtacaaa tgctagctaa ctataacatt ggctaccagg gcttctatat    26400

cccagagagc tacaaggacc gcatgtactc cttctttaga aacttccagc ccatgagccg    26460

tcaggtggtg gatgatacta aatacaagga ctaccaacag gtgggcatcc tacaccaaca    26520

caacaactct ggatttgttg gctaccttgc ccccaccatg cgcgaaggac aggcctaccc    26580

tgctaacttc ccctatccgc ttataggcaa gaccgcagtt gacagcatta cccagaaaaa    26640

gtttctttgc gatcgcaccc tttggcgcat cccattctcc agtaacttta tgtccatggg    26700

cgcactcaca gacctgggcc aaaaccttct ctacgccaac tccgcccacg cgctagacat    26760

gacttttgag gtggatccca tggacgagcc cacccttctt tatgttttgt ttgaagtctt    26820

tgacgtggtc cgtgtgcacc agccgcaccg cggcgtcatc gaaaccgtgt acctgcgcac    26880

gcccttctcg gccggcaacg ccacaacata aagaagcaag caacatcaac aacagctgcc    26940

gccatgggct ccagtgagca ggaactgaaa gccattgtca aagatcttgg ttgtgggcca    27000

tattttttgg gcacctatga caagcgcttt ccaggctttg tttctccaca caagctcgcc    27060

tgcgccatag tcaatacggc cggtcgcgag actgggggcg tacactggat ggcctttgcc    27120

tggaacccgc actcaaaaac atgctacctc tttgagccct ttggcttttc tgaccagcga    27180

ctcaagcagg tttaccagtt tgagtacgag tcactcctgc gccgtagcgc cattgcttct    27240

tcccccgacc gctgtataac gctggaaaag tccacccaaa gcgtacaggg gcccaactcg    27300

gccgcctgtg gactattctg ctgcatgttt ctccacgcct ttgccaactg gccccaaact    27360

cccatggatc acaaccccac catgaacctt attaccgggg tacccaactc catgctcaac    27420

agtccccagg tacagcccac cctgcgtcgc aaccaggaac agctctacag cttcctggag    27480

cgccactcgc cctacttccg cagccacagt gcgcagatta ggagcgccac ttctttttgt    27540

cacttgaaaa acatgtaaaa ataatgtact agagacactt tcaataaagg caaatgcttt    27600

tatttgtaca ctctcgggtg attatttacc cccacccttg ccgtctgcgc cgtttaaaaa    27660

tcaaaggggt tctgccgcgc atcgctatgc gccactggca gggacacgtt gcgatactgg    27720

tgtttagtgc tccacttaaa ctcaggcaca accatccgcg gcagctcggt gaagttttca    27780

ctccacaggc tgcgcaccat caccaacgcg tttagcaggt cgggcgccga tatcttgaag    27840

tcgcagttgg ggcctccgcc ctgcgcgcgc gagttgcgat acacagggtt gcagcactgg    27900

aacactatca gcgccgggtg gtgcacgctg gccagcacgc tcttgtcgga gatcagatcc    27960

gcgtccaggt cctccgcgtt gctcagggcg aacggagtca actttggtag ctgccttccc    28020

aaaaagggcg cgtgcccagg ctttgagttg cactcgcacc gtagtggcat caaaaggtga    28080

ccgtgcccgg tctgggcgtt aggatacagc gcctgcataa aagccttgat ctgcttaaaa    28140

gccacctgag cctttgcgcc ttcagagaag aacatgccgc aagacttgcc ggaaaactga    28200

ttggccggac aggccgcgtc gtgcacgcag caccttgcgt cggtgttgga gatctgcacc    28260

acatttcggc cccaccggtt cttcacgatc ttggccttgc tagactgctc cttcagcgcg    28320

cgctgcccgt tttcgctcgt cacatccatt tcaatcacgt gctccttatt tatcataatg    28380

cttccgtgta gacacttaag ctcgccttcg atctcagcgc agcggtgcag ccacaacgcg    28440

cagcccgtgg gctcgtgatg cttgtaggtc acctctgcaa acgactgcag gtacgcctgc    28500

aggaatcgcc ccatcatcgt cacaaaggtc ttgttgctgg tgaaggtcag ctgcaacccg    28560

cggtgctcct cgttcagcca ggtcttgcat acggccgcca gagcttccac ttggtcaggc    28620

agtagtttga agttcgcctt tagatcgtta tccacgtggt acttgtccat cagcgcgcgc    28680

gcagcctcca tgcccttctc ccacgcagac acgatcggca cactcagcgg gttcatcacc    28740

gtaatttcac tttccgcttc gctgggctct tcctcttcct cttgcgtccg cataccacgc    28800

gccactgggt cgtcttcatt cagccgccgc actgtgcgct tacctccttt gccatgcttg    28860

attagcaccg gtgggttgct gaaacccacc atttgtagcg ccacatcttc tctttcttcc    28920

tcgctgtcca cgattacctc tggtgatggc gggcgctcgg gcttgggaga agggcgcttc    28980

tttttcttct tgggcgcaat ggccaaatcc gccgccgagg tcgatggccg cgggctgggt    29040

gtgcgcggca ccagcgcgtc ttgtgatgag tcttcctcgt cctcggactc gatacgccgc    29100

ctcatccgct tttttggggg cgcccgggga ggcggcggcg acggggacgg ggacgacacg    29160

tcctccatgg ttgggggacg tcgcgccgca ccgcgtccgc gctcgggggt ggtttcgcgc    29220

tgctcctctt cccgactggc catttccttc tcctataggc agaaaaagat catggagtca    29280

gtcgagaaga aggacagcct aaccgccccc tctgagttcg ccaccaccgc ctccaccgat    29340

gccgccaacg cgcctaccac cttccccgtc gaggcacccc cgcttgagga ggaggaagtg    29400

attatcgagc aggacccagg ttttgtaagc gaagacgacg aggaccgctc agtaccaaca    29460

gaggataaaa agcaagacca ggacaacgca gaggcaaacg aggaacaagt cgggcggggg    29520

gacgaaaggc atggcgacta cctagatgtg ggagacgacg tgctgttgaa gcatctgcag    29580

cgccagtgcg ccattatctg cgacgcgttg caagagcgca gcgatgtgcc cctcgccata    29640

gcggatgtca gccttgccta cgaacgccac ctattctcac cgcgcgtacc ccccaaacgc    29700

caagaaaacg gcacatgcga gcccaacccg cgcctcaact tctaccccgt atttgccgtg    29760

ccagaggtgc ttgccaccta tcacatcttt ttccaaaact gcaagatacc cctatcctgc    29820

cgtgccaacc gcagccgagc ggacaagcag ctggccttgc ggcagggcgc tgtcatacct    29880

gatatcgcct cgctcaacga agtgccaaaa atctttgagg gtcttggacg cgacgagaag    29940

cgcgcggcaa acgctctgca acaggaaaac agcgaaaatg aaagtcactc tggagtgttg    30000

gtggaactcg agggtgacaa cgcgcgccta gccgtactaa aacgcagcat cgaggtcacc    30060

cactttgcct acccggcact taacctaccc cccaaggtca tgagcacagt catgagtgag    30120

ctgatcgtgc gccgtgcgca gcccctggag agggatgcaa atttgcaaga acaaacagag    30180

gagggcctac ccgcagttgg cgacgagcag ctagcgcgct ggcttcaaac gcgcgagcct    30240

gccgacttgg aggagcgacg caaactaatg atggccgcag tgctcgttac cgtggagctt    30300

gagtgcatgc agcggttctt tgctgacccg gagatgcagc gcaagctaga ggaaacattg    30360

cactacacct ttcgacaggg ctacgtacgc caggcctgca agatctccaa cgtggagctc    30420

tgcaacctgg tctcctacct tggaattttg cacgaaaacc gccttgggca aaacgtgctt    30480

cattccacgc tcaagggcga ggcgcgccgc gactacgtcc gcgactgcgt ttacttattt    30540

ctatgctaca cctggcagac ggccatgggc gtttggcagc agtgcttgga ggagtgcaac    30600

ctcaaggagc tgcagaaact gctaaagcaa aacttgaagg acctatggac ggccttcaac    30660

gagcgctccg tggccgcgca cctggcggac atcattttcc ccgaacgcct gcttaaaacc    30720

ctgcaacagg gtctgccaga cttcaccagt caaagcatgt tgcagaactt taggaacttt    30780

atcctagagc gctcaggaat cttgcccgcc acctgctgtg cacttcctag cgactttgtg    30840

cccattaagt accgcgaatg ccctccgccg ctttggggcc actgctacct tctgcagcta    30900

gccaactacc ttgcctacca ctctgacata atggaagacg tgagcggtga cggtctactg    30960

gagtgtcact gtcgctgcaa cctatgcacc ccgcaccgct ccctggtttg caattcgcag    31020

ctgcttaacg aaagtcaaat tatcggtacc tttgagctgc agggtccctc gcctgacgaa    31080

aagtccgcgg ctccggggtt gaaactcact ccggggctgt ggacgtcggc ttaccttcgc    31140

aaatttgtac ctgaggacta ccacgcccac gagattaggt tctacgaaga ccaatcccgc    31200

ccgcctaatg cggagcttac cgcctgcgtc attacccagg gccacattct tggccaattg    31260

caagccatca acaaagcccg ccaagagttt ctgctacgaa agggacgggg ggtttacttg    31320

gacccccagt ccggcgagga gctcaaccca atccccccgc cgccgcagcc ctatcagcag    31380

cagccgcggg cccttgcttc ccaggatggc acccaaaaag aagctgcagc tgccgccgcc    31440

acccacggac gaggaggaat actgggacag tcaggcagag gaggttttgg acgaggagga    31500

ggaggacatg atggaagact gggagagcct agacgaggaa gcttccgagg tcgaagaggt    31560

gtcagacgaa acaccgtcac cctcggtcgc attcccctcg ccggcgcccc agaaatcggc    31620

aaccggttcc agcatggcta caacctccgc tcctcaggcg ccgccggcac tgcccgttcg    31680

ccgacccaac cgtagatggg acaccactgg aaccagggcc ggtaagtcca agcagccgcc    31740

gccgttagcc caagagcaac aacagcgcca aggctaccgc tcatggcgcg ggcacaagaa    31800

cgccatagtt gcttgcttgc aagactgtgg gggcaacatc tccttcgccc gccgctttct    31860

tctctaccat cacggcgtgg ccttcccccg taacatcctg cattactacc gtcatctcta    31920

cagcccatac tgcaccggcg gcagcggcag caacagcagc ggccacacag aagcaaaggc    31980

gaccggatag caagactctg acaaagccca agaaatccac agcggcggca gcagcaggag    32040

gaggagcgct gcgtctggcg cccaacgaac ccgtatcgac ccgcgagctt agaaacagga    32100

tttttcccac tctgtatgct atatttcaac agagcagggg ccaagaacaa gagctgaaaa    32160

taaaaaacag gtctctgcga tccctcaccc gcagctgcct gtatcacaaa agcgaagatc    32220

agcttcggcg cacgctggaa gacgcggagg ctctcttcag taaatactgc gcgctgactc    32280

ttaaggacta gtttcgcgcc ctttctcaaa tttaagcgcg aaaactacgt catctccagc    32340

ggccacaccc ggcgccagca cctgttgtca gcgccattat gagcaaggaa attcccacgc    32400

cctacatgtg gagttaccag ccacaaatgg gacttgcggc tggagctgcc caagactact    32460

caacccgaat aaactacatg agcgcgggac cccacatgat atcccgggtc aacggaatac    32520

gcgcccaccg aaaccgaatt ctcctggaac aggcggctat taccaccaca cctcgtaata    32580

accttaatcc ccgtagttgg cccgctgccc tggtgtacca ggaaagtccc gctcccacca    32640

ctgtggtact tcccagagac gcccaggccg aagttcagat gactaactca ggggcgcagc    32700

ttgcgggcgg ctttcgtcac agggtgcggt cgcccgggca gggtataact cacctgacaa    32760

tcagagggcg aggtattcag ctcaacgacg agtcggtgag ctcctcgctt ggtctccgtc    32820

cggacgggac atttcagatc ggcggcgccg gccgctcttc attcacgcct cgtcaggcaa    32880

tcctaactct gcagacctcg tcctctgagc cgcgctctgg aggcattgga actctgcaat    32940

ttattgagga gtttgtgcca tcggtctact ttaacccctt ctcgggacct cccggccact    33000

atccggatca atttattcct aactttgacg cggtaaagga ctcggcggac ggctacgact    33060

gaatgttaag tggagaggca gagcaactgc gcctgaaaca cctggtccac tgtcgccgcc    33120

acaagtgctt tgcccgcgac tccggtgagt tttgctactt tgaattgccc gaggatcata    33180

tcgagggccc ggcgcacggc gtccggctta ccgcccaggg agagcttgcc cgtagcctga    33240

ttcgggagtt tacccagcgc cccctgctag ttgagcggga caggggaccc tgtgttctca    33300

ctgtgatttg caactgtcct aaccctggat tacatcaaga tcctctagtt aatgtcaggt    33360

cgcctaagtc gattaactag agtacccggg gatcttattc cctttaacta ataaaaaaaa    33420

ataataaagc atcacttact taaaatcagt tagcaaattt ctgtccagtt tattcagcag    33480

cacctccttg ccctcctccc agctctggta ttgcagcttc ctcctggctg caaactttct    33540

ccacaatcta aatggaatgt cagtttcctc ctgttcctgt ccatccgcac ccactatctt    33600

catgttgttg cagatgaagc gcgcaagacc gtctgaagat accttcaacc ccgtgtatcc    33660

atatgacacg gaaaccggtc ctccaactgt gccttttctt actcctccct ttgtatcccc    33720

caatgggttt caagagagtc cccctggggt actctctttg cgcctatccg aacctctagt    33780

tacctccaat ggcatgcttg cgctcaaaat gggcaacggc ctctctctgg acgaggccgg    33840

caaccttacc tcccaaaatg taaccactgt gagcccacct ctcaaaaaaa ccaagtcaaa    33900

cataaacctg gaaatatctg cacccctcac agttacctca gaagccctaa ctgtggctgc    33960

cgccgcacct ctaatggtcg cgggcaacac actcaccatg caatcacagg ccccgctaac    34020

cgtgcacgac tccaaactta gcattgccac ccaaggaccc ctcacagtgt cagaaggaaa    34080

gctagccctg caaacatcag gccccctcac caccaccgat agcagtaccc ttactatcac    34140

tgcctcaccc cctctaacta ctgccactgg tagcttgggc attgacttga aagagcccat    34200

ttatacacaa aatggaaaac taggactaaa gtacggggct cctttgcatg taacagacga    34260

cctaaacact ttgaccgtag caactggtcc aggtgtgact attaataata cttccttgca    34320

aactaaagtt actggagcct tgggttttga ttcacaaggc aatatgcaac ttaatgtagc    34380

aggaggacta aggattgatt ctcaaaacag acgccttata cttgatgtta gttatccgtt    34440

tgatgctcaa aaccaactaa atctaagact aggacagggc cctcttttta taaactcagc    34500

ccacaacttg gatattaact acaacaaagg cctttacttg tttacagctt caaacaattc    34560

caaaaagctt gaggttaacc taagcactgc caaggggttg atgtttgacg ctacagccat    34620

agccattaat gcaggagatg ggcttgaatt tggttcacct aatgcaccaa acacaaatcc    34680

cctcaaaaca aaaattggcc atggcctaga atttgattca aacaaggcta tggttcctaa    34740

actaggaact ggccttagtt ttgacagcac aggtgccatt acagtaggaa acaaaaataa    34800

tgataagcta actttgtgga ccacaccagc tccatctcct aactgtagac taaatgcaga    34860

gaaagatgct aaactcactt tggtcttaac aaaatgtggc agtcaaatac ttgctacagt    34920

ttcagttttg gctgttaaag gcagtttggc tccaatatct ggaacagttc aaagtgctca    34980

tcttattata agatttgacg aaaatggagt gctactaaac aattccttcc tggacccaga    35040

atattggaac tttagaaatg gagatcttac tgaaggcaca gcctatacaa acgctgttgg    35100

atttatgcct aacctatcag cttatccaaa atctcacggt aaaactgcca aaagtaacat    35160

tgtcagtcaa gtttacttaa acggagacaa aactaaacct gtaacactaa ccattacact    35220

aaacggtaca caggaaacag gagacacaac tccaagtgca tactctatgt cattttcatg    35280

ggactggtct ggccacaact acattaatga aatatttgcc acatcctctt acactttttc    35340

atacattgcc caagaataaa gaatcgtttg tgttatgttt caacgtgttt atttttcaat    35400

tgcagaaaat ttcaagtcat ttttcattca gtagtatagc cccaccacca catagcttat    35460

acagatcacc gtaccttaat caaactcaca gaaccctagt attcaacctg ccacctccct    35520

cccaacacac agagtacaca gtcctttctc cccggctggc cttaaaaagc atcatatcat    35580

gggtaacaga catattctta ggtgttatat tccacacggt ttcctgtcga gccaaacgct    35640

catcagtgat attaataaac tccccgggca gctcacttaa gttcatgtcg ctgtccagct    35700

gctgagccac aggctgctgt ccaacttgcg gttgcttaac gggcggcgaa ggagaagtcc    35760

acgcctacat gggggtagag tcataatcgt gcatcaggat agggcggtgg tgctgcagca    35820

gcgcgcgaat aaactgctgc cgccgccgct ccgtcctgca ggaatacaac atggcagtgg    35880

tctcctcagc gatgattcgc accgcccgca gcataaggcg ccttgtcctc cgggcacagc    35940

agcgcaccct gatctcactt aaatcagcac agtaactgca gcacagcacc acaatattgt    36000

tcaaaatccc acagtgcaag gcgctgtatc caaagctcat ggcggggacc acagaaccca    36060

cgtggccatc ataccacaag cgcaggtaga ttaagtggcg acccctcata aacacgctgg    36120

acataaacat tacctctttt ggcatgttgt aattcaccac ctcccggtac catataaacc    36180

tctgattaaa catggcgcca tccaccacca tcctaaacca gctggccaaa acctgcccgc    36240

cggctataca ctgcagggaa ccgggactgg aacaatgaca gtggagagcc caggactcgt    36300

aaccatggat catcatgctc gtcatgatat caatgttggc acaacacagg cacacgtgca    36360

tacacttcct caggattaca agctcctccc gcgttagaac catatcccag ggaacaaccc    36420

attcctgaat cagcgtaaat cccacactgc agggaagacc tcgcacgtaa ctcacgttgt    36480

gcattgtcaa agtgttacat tcgggcagca gcggatgatc ctccagtatg gtagcgcggg    36540

tttctgtctc aaaaggaggt agacgatccc tactgtacgg agtgcgccga gacaaccgag    36600

atcgtgttgg tcgtagtgtc atgccaaatg gaacgccgga cgtagtcata tttcctgaag    36660

caaaaccagg tgcgggcgtg acaaacagat ctgcgtctcc ggtctcgccg cttagatcgc    36720

tctgtgtagt agttgtagta tatccactct ctcaaagcat ccaggcgccc cctggcttcg    36780

ggttctatgt aaactccttc atgcgccgct gccctgataa catccaccac cgcagaataa    36840

gccacaccca gccaacctac acattcgttc tgcgagtcac acacgggagg agcgggaaga    36900

gctggaagaa ccatgttttt ttttttattc caaaagatta tccaaaacct caaaatgaag    36960

atctattaag tgaacgcgct cccctccggt ggcgtggtca aactctacag ccaaagaaca    37020

gataatggca tttgtaagat gttgcacaat ggcttccaaa aggcaaacgg ccctcacgtc    37080

caagtggacg taaaggctaa acccttcagg gtgaatctcc tctataaaca ttccagcacc    37140

ttcaaccatg cccaaataat tctcatctcg ccaccttctc aatatatctc taagcaaatc    37200

ccgaatatta agtccggcca ttgtaaaaat ctgctccaga gcgccctcca ccttcagcct    37260

caagcagcga atcatgattg caaaaattca ggttcctcac agacctgtat aagattcaaa    37320

agcggaacat taacaaaaat accgcgatcc cgtaggtccc ttcgcagggc cagctgaaca    37380

taatcgtgca ggtctgcacg gaccagcgcg gccacttccc cgccaggaac catgacaaaa    37440

gaacccacac tgattatgac acgcatactc ggagctatgc taaccagcgt agccccgatg    37500

taagcttgtt gcatgggcgg cgatataaaa tgcaaggtgc tgctcaaaaa atcaggcaaa    37560

gcctcgcgca aaaaagaaag cacatcgtag tcatgctcat gcagataaag gcaggtaagc    37620

tccggaacca ccacagaaaa agacaccatt tttctctcaa acatgtctgc gggtttctgc    37680

ataaacacaa aataaaataa caaaaaaaca tttaaacatt agaagcctgt cttacaacag    37740

gaaaaacaac ccttataagc ataagacgga ctacggccat gccggcgtga ccgtaaaaaa    37800

actggtcacc gtgattaaaa agcaccaccg acagctcctc ggtcatgtcc ggagtcataa    37860

tgtaagactc ggtaaacaca tcaggttgat tcacatcggt cagtgctaaa aagcgaccga    37920

aatagcccgg gggaatacat acccgcaggc gtagagacaa cattacagcc cccataggag    37980

gtataacaaa attaatagga gagaaaaaca cataaacacc tgaaaaaccc tcctgcctag    38040

gcaaaatagc accctcccgc tccagaacaa catacagcgc ttccacagcg gcagccataa    38100

cagtcagcct taccagtaaa aaagaaaacc tattaaaaaa acaccactcg acacggcacc    38160

agctcaatca gtcacagtgt aaaaaagggc caagtgcaga gcgagtatat ataggactaa    38220

aaaatgacgt aacggttaaa gtccacaaaa aacacccaga aaaccgcacg cgaacctacg    38280

cccagaaacg aaagccaaaa aacccacaac ttcctcaaat cgtcacttcc gttttcccac    38340

gttacgtcac ttcccatttt aagaaaacta caattcccaa cacatacaag ttactccgcc    38400

ctaaaaccta cgtcacccgc cccgttccca cgccccgcgc cacgtcacaa actccacccc    38460

ctcattatca tattggcttc aatccaaaat aaggta                              38496


<210>  229
<211>  9701
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  vector for IgG1 against T27Y H34A H378N ACE2 mutant


<220>
<221>  misc_feature
<222>  (2929)..(2930)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (2934)..(2934)
<223>  n is a, c, g, or t

<400>  229
ggcgtaatct gctgcttgca aacaaaaaaa ccaccgctac cagcggtggt ttgtttgccg       60

gatcaagagc taccaactct ttttccgaag gtaactggct tcagcagagc gcagatacca      120

aatactgtcc ttctagtgta gccgtagtta ggccaccact tcaagaactc tgtagcaccg      180

cctacatacc tcgctctgct gaagccagtt accagtggct gctgccagtg gcgataagtc      240

gtgtcttacc gggttggact caagagatag ttaccggata aggcgcagcg gtcgggctga      300

acggggggtt cgtgcacaca gcccagcttg gagcgaacga cctacaccga actgagatac      360

ctacagcgtg agctatgaga aagcgccacg cttcccgaag ggagaaaggc ggacaggtat      420

ccggtaagcg gcagggtcgg aacaggagag cgcacgaggg agcttccagg gggaaacgcc      480

tggtatcttt atagtcctgt cgggtttcgc cacctctgac ttgagcgtcg atttttgtga      540

tgctcgtcag gggggcggag cctatggaaa aacgccagca acgcaagcta gagtttaaac      600

ttgacagatg agacaataac cctgataaat gcttcaataa tattgaaaaa ggaaaagtat      660

gagtattcaa catttccgtg tcgcccttat tccctttttt gcggcatttt gccttcctgt      720

ttttgctcac ccagaaacgc tggtgaaagt aaaagatgca gaagatcact tgggtgcgcg      780

agtgggttac atcgaactgg atctcaacag cggtaagatc cttgagagtt ttcgccccga      840

agaacgtttc ccaatgatga gcacttttaa agttctgcta tgtggcgcgg tattatcccg      900

tattgatgcc gggcaagagc aactcggtcg ccgcatacac tattctcaga atgacttggt      960

tgaatactca ccagtcacag aaaagcatct tacggatggc atgacagtaa gagaattatg     1020

cagtgctgcc ataaccatga gtgataacac tgcggccaac ttacttctga caactatcgg     1080

aggaccgaag gagctaaccg cttttttgca caacatgggg gatcatgtaa ctcgccttga     1140

tcgttgggaa ccggagctga atgaagccat accaaacgac gagcgtgaca ccacgatgcc     1200

tgtagcaatg gcaacaacgt tgcgaaaact attaactggc gaactactta ctctagcttc     1260

ccggcaacaa ctaatagact ggatggaggc ggataaagtt gcaggaccac ttctgcgctc     1320

ggcacttccg gctggctggt ttattgctga taaatcagga gccggtgagc gtgggtcacg     1380

cggtatcatt gcagcactgg ggccggatgg taagccctcc cgtatcgtag ttatctacac     1440

tacggggagt caggcaacta tggatgaacg aaatagacag atcgctgaga taggtgcctc     1500

actgattaag cattggtaag gataaatttc tggtaaggag gacacgtatg gaagtgggca     1560

agttggggaa gccgtatccg ttgctgaatc tggcatatgt gggagtataa gacgcgcagc     1620

gtcgcatcag gcattttttt ctgcgccaat gcaaaaaggc catccgtcag gatggccttt     1680

cggcataact agggccgccg atatttgaaa atatggcata ttgaaaatgt cgccgatgtg     1740

agtttctgtg taactgatat cgccattttt ccaaaagtga tttttgggca tacgcgatat     1800

ctggcgatag cgcttatatc gtttacgggg gatggcgata gacgactttg gtgacttggg     1860

cgattctgtg tgtcgcaaat atcgcagttt cgatataggt gacagacgat atgaggctat     1920

atcgccgata gaggcgacat caagctggca catggccaat gcatatcgat ctatacattg     1980

aatcaatatt ggccattagc catattattc attggttata tagcataaat caatattggc     2040

tattggccat tgcatacgtt gtatccatat cataatatgt acatttatat tggctcatgt     2100

ccaacattac cgccatgttg acattgatta ttgactagtt attaatagta atcaattacg     2160

gggtcattag ttcatagccc atatatggag ttccgcgtta cataacttac ggtaaatggc     2220

ccgcctggct gaccgcccaa cgacccccgc ccattgacgt caataatgac gtatgttccc     2280

atagtaacgc caatagggac tttccattga cgtcaatggg tggagtattt acggtaaact     2340

gcccacttgg cagtacatca agtgtatcat atgccaagta cgccccctat tgacgtcaat     2400

gacggtaaat ggcccgcctg gcattatgcc cagtacatga ccttatggga ctttcctact     2460

tggcagtaca tctacgtatt agtcatcgct attaccatgg tgatgcggtt ttggcagtac     2520

atcaatgggc gtggatagcg gtttgactca cggggatttc caagtctcca ccccattgac     2580

gtcaatggga gtttgttttg gcaccaaaat caacgggact ttccaaaatg tcgtaacaac     2640

tccgccccat tgacgcaaat gggcggtagg cgtgtacggt gggaggtcta tataagcaga     2700

gctcgtttag tgaaccgtca gatcgcctgg agacgccatc cacgctgttt tgacctccat     2760

agaagacacc gggaccgatc cagcctccgc ggccgggaac ggtgcattgg aacgcggatt     2820

ccccgtgcca agagtgacgt aagtaccgcc tatagagtct ataggcccac ccccttggct     2880

tcttatgcat gctatactgt ttttggcttg gggtctatac accccccgnn ttcntcatgt     2940

tataggtgat ggtatagctt agcctatagg tgtgggttat tgaccattat tgaccactcc     3000

ccctattggt gacgatactt tccattacta atccataaca tggctctttg ccacaactct     3060

ctttattggc tatatgccaa tacactgtcc ttcagagact gacacggact ctgtattttt     3120

acaggatggg gtctcattta ttatttacaa attcacatat acaacaccac cgtccccagt     3180

gcccgcagtt tttattaaac ataacgtggg atctccacgc gaatctcggg tacgtgttcc     3240

ggacatgggc tcttctccgg tagcggcgga gcttctacat ccgagccctg ctcccatgcc     3300

tccagcgact catggtcgct cggcagctcc ttgctcctaa cagtggaggc cagacttagg     3360

cacagcacga tgcccaccac caccagtgtg ccgcacaagg ccgtggcggt agggtatgtg     3420

tctgaaaatg agctcgggga gcgggcttgc accgctgacg catttggaag acttaaggca     3480

gcggcagaag aagatgcagg cagctgagtt gttgtgttct gataagagtc agaggtaact     3540

cccgttgcgg tgctgttaac ggtggagggc agtgtagtct gagcagtact cgttgctgcc     3600

gcgcgcgcca ccagacataa tagctgacag actaacagac tgttcctttc catgggtctt     3660

ttctgcagtc accgtccttg acacgaagct gctagcgcca ccatgagcag cagtagttgg     3720

cttctcttga gtttggtggc agtgacagca gcccagagta ctatcgagga gcaggctaaa     3780

tactttctgg ataagtttaa cgccgaggcc gaagacttgt tctatcaatc ttctctcgct     3840

tcatggaatt acaatactaa catcactgag gagaacgtcc agaatatgaa caatgctggc     3900

gacaaatgga gcgccttctt gaaggagcag tctacccttg cacaaatgta tccactgcag     3960

gagatacaga accttacagt aaagttgcag ctccaggctc tccagcagaa cggatctagc     4020

gtgctttcag aggataaaag caaaaggctg aacaccatac ttaataccat gtccacaatt     4080

tactctactg gtaaagtatg taaccccgac aaccctcaag aatgcctcct tcttgagcca     4140

ggcctcaatg agatcatggc taatagtctg gactataatg aaagactgtg ggcatgggag     4200

tcctggagat ctgaagtagg gaagcaactg aggccccttt atgaagagta cgtcgtactt     4260

aagaatgaaa tggcccgcgc taaccactac gaggattacg gcgattactg gcgtggggac     4320

tatgaagtaa atggtgtaga tggatacgac tatagtcgtg ggcaattgat tgaggatgtg     4380

gagcacactt ttgaggagat aaaaccactc tatgagcatc ttcacgcata tgtgagagct     4440

aaactgatga acgcctaccc aagttacatc agtccaatcg gatgtctccc agctcacctc     4500

cttggcgaca tgtggggacg tttctggacc aatctgtatt ccctcacagt ccctttcggg     4560

caaaagccta atatagacgt gacagacgca atggttgatc aggcttggga tgctcaaagg     4620

atttttaagg aagctgagaa gttttttgtg tcagtcggtt tgccaaatat gacacaaggc     4680

ttctgggaaa atagcatgtt gactgatccc ggtaatgttc aaaaggctgt gtgtcaccct     4740

accgcttggg accttgggaa aggtgacttt cgaatcttga tgtgtaccaa ggtgacaatg     4800

gatgactttc ttacagccca tcatgaaatg ggtaatatcc agtatgatat ggcttatgca     4860

gctcaacctt tcctcttgag aaatggtgca aatgaaggtt ttcatgaagc tgtaggggaa     4920

ataatgtccc tgagtgctgc aaccccaaag catctcaaga gtatcggatt gttgagccca     4980

gattttcaag aagataacga gaccgaaatc aacttccttc tgaaacaagc cctcacaata     5040

gttggtactc ttccattcac atacatgctg gagaaatggc gttggatggt ttttaagggg     5100

gagataccta aagatcagtg gatgaaaaag tggtgggaga tgaagcgtga gatcgtaggg     5160

gtcgtggagc cagtgcctca tgatgagact tactgtgacc cagcatcact cttccacgtt     5220

agcaatgact attcatttat acgttattac actcgcactc tttaccagtt tcaatttcag     5280

gaggctctgt gtcaggctgc caagcatgag ggaccccttc acaagtgtga tattagtaac     5340

agtactgagg caggccaaaa actgttcaat atgttgaggc ttggcaaaag cgagccatgg     5400

actctcgcct tggaaaatgt tgtcggggct aaaaacatga atgtacgccc tctgcttaac     5460

tattttgagc ccctttttac atggctcaag gaccagaata agaactcctt tgtcggctgg     5520

tcaacagact ggtctcccta tgcagacaaa acacatactt gcccaccttg tcctgcacca     5580

gagctgctgg gaggtccaag cgtgttcctg tttccaccca agcccaaaga cacactgatg     5640

atttctcgaa ctccagaagt gacctgcgtg gtcgtggacg tgagccacga ggatcccgaa     5700

gtgaagttca actggtacgt ggatggcgtg gaggtccata atgctaagac taaaccccgg     5760

gaggaacagt acaacagcac ttatagggtc gtgtccgtgc tgaccgtcct gcatcaggat     5820

tggctgaacg ggaaggaata taagtgcaaa gtgtctaata aggcactgcc cgcccctatc     5880

gagaaaacaa ttagcaaggc taagggtcag cctagagaac cacaggtgta cactctgcct     5940

ccaagtcgcg acgagctgac caagaaccag gtgtcactga catgtctggt caaaggcttt     6000

tatccctcag atatcgcagt ggagtgggaa agcaatggac agcctgagaa caattacaag     6060

accacacccc ctgtgctgga cagtgatggc tcattctttc tgtattctaa gctgacagtg     6120

gacaaaagta ggtggcagca gggaaacgtg ttctcctgct ctgtcatgca cgaagcactg     6180

cacaatcatt atacccagaa gagtctgtca ctgagccctg gcaaatgagc gataccgatt     6240

ctagaactag atcataatca gccataccac atttgtagag gttttacttg ctttaaaaaa     6300

cctcccacac ctccccctga acctgaaaca taaaatgaat gcaattgttg ttgttaactt     6360

gtttattgca gcttataatg gttacaaata aagcaatagc atcacaaatt tcacaaataa     6420

agcatttttt tcactgcatt ctagttgtgg tttgtccaaa ctcatcaatg tatcttaagg     6480

ccgcaggtaa gccagcccag gcctcgccct ccagctcaag gcgggacagg tgccctagag     6540

tagcctgcat ccagggacag gccccagccg ggtgctgaca cgtccacctc catctcttcc     6600

tcaggtctgc ccgggtggca tccctgtgac ccctccccag tgcctctcct ggtcgtggaa     6660

ggtgctactc cagtgcccac cagccttgtc ctaataaaat taagttgcat cattttgttt     6720

gactaggtgt ccttgtataa tattatgggg tggaggcggg tggtatggag caaggggccc     6780

aagttaactt gtttattgca gcttataatg gttacaaata aagcaatagc atcacaaatt     6840

tcacaaataa agcatttttt tcactgcatt ctagttgtgg tttgtccaaa ctcatcaatg     6900

tatcttatca tgtctggatc cgcttcaggc accgggcttg cgggtcatgc accaggtgcg     6960

cggtccttcg ggcacctcga cgtcggcggt gacggtgaag ccgagccgct cgtagaaggg     7020

gaggttgcgg ggcgcggagg tctccaggaa ggcgggcacc ccggcgcgct cggccgcctc     7080

cactccgggg agcacgacgg cgctgcccag acccttgccc tggtggtcgg gcgagacgcc     7140

gacggtggcc aggaaccacg cgggctcctt gggccggtgc ggcgccagga ggccttccat     7200

ctgttgctgc gcggccagcc tggaaccgct caactcggcc atgcgcgggc cgatctcggc     7260

gaacaccgcc cccgcttcga cgctctccgg cgtggtccag accgccaccg cggcgccgtc     7320

gtccgcgacc cacaccttgc cgatgtcgag cccgacgcgc gtgaggaaga gttcttgcag     7380

ctcggtgacc cgctcgatgt ggcggtccgg gtcgacggtg tggcgcgtgg cggggtagtc     7440

ggcgaacgcg gcggcgaggg tgcgtacggc ccgggggacg tcgtcgcggg tggcgaggcg     7500

caccgtgggc ttgtactcgg tcatggtggc ctgcagagtc gctctgtgtt cgaggccaca     7560

cgcgtcacct taatatgcga agtggacctg ggaccgcgcc gccccgactg catctgcgtg     7620

ttttcgccaa tgacaagacg ctgggcgggg tttgtgtcat catagaacta aagacatgca     7680

aatatatttc ttccggggac accgccagca aacgcgagca acgggccacg gggatgaagc     7740

agctgcgcca ctccctgaag atccatcgtc tcctaacaag ttacatcact cctgcccttc     7800

ctcaccctca tctccatcac ctccttcatc tccgtcatct ccgtcatcac cctccgcggc     7860

agccccttcc accataggtg gaaaccaggg aggcaaatct actccatcgt caaagctgca     7920

cacagtcacc ctgatattgc aggtaggagc gggctttgtc ataacaaggt ccttaatcgc     7980

atccttcaaa acctcagcaa atatatgagt ttgtaaaaag accatgaaat aacagacaat     8040

ggactccctt agcgggccag gttgtgggcc gggtccaggg gccattccaa aggggagacg     8100

actcaatggt gtaagacgac attgtggaat agcaagggca gttcctcgcc ttaggttgta     8160

aagggaggtc ttactacctc catatacgaa cacaccggcg acccaagttc cttcgtcggt     8220

agtcctttct acgtgactcc tagccaggag agctcttaaa ccttctgcaa tgttctcaaa     8280

tttcgggttg gaacctcctt gaccacgatg ctttccaaac caccctcctt ttttgcgcct     8340

gcctccatca ccctgacccc cgctgcgcgg gggcacgtca ggctcaccat ctgggccgcc     8400

ttcttggtgg tattcaaaat aatcggcttc ccctacaggg tggaaaaatg gccttctacc     8460

tggagggggc ctgcgcggtg gagacccgga tgatgatgac tgactactgg gactcctggg     8520

cctcttttct ccacgtccac gacctctccc cctggctctt tcacgacttc cccccctggc     8580

tctttcacgt cctctacccc ggcggcctcc actacctcct cgaccccggc ctccactacc     8640

tcctcgaccc cggcctccac tgcctcctcg accccggcct ccacctcctg ctcctgcccc     8700

tcccgctcct gctcctgctc ctgttccacc gtgggtccct ttgcagccaa tgcaacttgg     8760

acgtttttgg ggtctccgga caccatctct atgtcttggc cctgatcctg agccgcccgg     8820

ggctcctggt cttccgcctc ctcgtcctcg tcctcttccc cgtcctcgtc catgtgccat     8880

gatggcggcc tgcagctgtg ttcgaggccg cgcgtgtcac cttaatatgc gaagtggacc     8940

tgggaccgcg ccgccccgac tgcatctgcg tgttcgagtt cgccaatgac aagacgctgg     9000

gcggggagat cccccttatt aaccctaaac gggtagcata tgcttcccgg gtagtagtat     9060

atactatcca gactaaccct aattcaatag catatgttac ccaacgggaa gcatatgcta     9120

tcgaattagg gttagtaaaa gggtcctaag gaacagcgat ctggatagca tatgctatcc     9180

taatctatat ctgggtagca tatgctatcc taatctatat ctgggtagca taggctatcc     9240

taatctatat ctgggtagca tatgctatcc taatctatat ctgggtagta tatgctatcc     9300

taatttatat ctgggtagca taggctatcc taatctatat ctgggtagca tatgctatcc     9360

taatctatat ctgggtagta tatgctatcc taatctgtat ccgggtagca tatgctatcc     9420

tcatgcatat acagtcagca tatgataccc agtagtagag tgggagtgct atcctttgca     9480

tatgccgcca cctcccaagg agatctgtcg acatcgatgg gcgcgggtgt acactccgcc     9540

catcccgccc ctaactccgc ccagttccgc ccattctccg cctcatggct gactaatttt     9600

ttttatttat gcagaggccg aggccgcctc ggcctctgag ctattccaga agtagtgagg     9660

aggctttttt ggaggcctag gcttttgcaa aaagctaatt c                         9701


<210>  230
<211>  38496
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  vector for IgA against T27Y H34A H345A ACE2 mutant

<400>  230
tattattgat gatgttaatt aacatgcatg gatcctacgt ctcgaccgat gcccttgaga       60

gccttcaacc cagtcagctc cttccggtgg gcgcggggca tgactatcgt cgccgcactt      120

atgactgtct tctttatcat gcaactcgta ggacaggtgc cggcagcgct ctgggtcatt      180

ttcggcgagg accgctttcg ctggagcgcg acgatgatcg gcctgtcgct tgcggtattc      240

ggaatcttgc acgccctcgc tcaagccttc gtcactggtc ccgccaccaa acgtttcggc      300

gagaagcagg ccattatcgc cggcatggcg gccgacgcgc tgggctacgt cttgctggcg      360

ttcgcgacgc gaggctggat ggccttcccc attatgattc ttctcgcttc cggcggcatc      420

gggatgcccg cgttgcaggc catgctgtcc aggcaggtag atgacgacca tcagggacag      480

cttcaaggat cgctcgcggc tcttaccagc ctaacttcga tcattggacc gctgatcgtc      540

acggcgattt atgccgcctc ggcgagcaca tggaacgggt tggcatggat tgtaggcgcc      600

gccctatacc ttgtctgcct ccccgcgttg cgtcgcggtg catggagccg ggccacctcg      660

acctgaatgg aagccggcgg cacctcgcta acggattcac cactccaaga attggagcca      720

atcaattctt gcggagaact gtgaatgcgc aaaccaaccc ttggcagaac atatccatcg      780

cgtccgccat ctccagcagc cgcacgcggc gcatctcggg cagcgttggg tcctggccac      840

gggtgcgcat gatcgtgctc ctgtcgttga ggacccggct aggctggcgg ggttgcctta      900

ctggttagca gaatgaatca ccgatacgcg agcgaacgtg aagcgactgc tgctgcaaaa      960

cgtctgcgac ctgagcaaca acatgaatgg tcttcggttt ccgtgtttcg taaagtctgg     1020

aaacgcggaa gtcagcgccc tgcaccatta tgttccggat ctgcatcgca ggatgctgct     1080

ggctaccctg tggaacacct acatctgtat taacgaagcg ctggcattga ccctgagtga     1140

tttttctctg gtcccgccgc atccataccg ccagttgttt accctcacaa cgttccagta     1200

accgggcatg ttcatcatca gtaacccgta tcgtgagcat cctctctcgt ttcatcggta     1260

tcattacccc catgaacaga aatccccctt acacggaggc atcagtgacc aaacaggaaa     1320

aaaccgccct taacatggcc cgctttatca gaagccagac attaacgctt ctggagaaac     1380

tcaacgagct ggacgcggat gaacaggcag acatctgtga atcgcttcac gaccacgctg     1440

atgagcttta ccgcagctgc ctcgcgcgtt tcggtgatga cggtgaaaac ctctgacaca     1500

tgcagctccc ggagacggtc acagcttgtc tgtaagcgga tgccgggagc agacaagccc     1560

gtcagggcgc gtcagcgggt gttggcgggt gtcggggcgc agccatgacc cagtcacgta     1620

gcgatagcgg agtgtatact ggcttaacta tgcggcatca gagcagattg tactgagagt     1680

gcaccatatg cggtgtgaaa taccgcacag atgcgtaagg agaaaatacc gcatcaggcg     1740

ctcttccgct tcctcgctca ctgactcgct gcgctcggtc gttcggctgc ggcgagcggt     1800

atcagctcac tcaaaggcgg taatacggtt atccacagaa tcaggggata acgcaggaaa     1860

gaacatgtga gcaaaaggcc agcaaaaggc caggaaccgt aaaaaggccg cgttgctggc     1920

gtttttccat aggctccgcc cccctgacga gcatcacaaa aatcgacgct caagtcagag     1980

gtggcgaaac ccgacaggac tataaagata ccaggcgttt ccccctggaa gctccctcgt     2040

gcgctctcct gttccgaccc tgccgcttac cggatacctg tccgcctttc tcccttcggg     2100

aagcgtggcg ctttctcata gctcacgctg taggtatctc agttcggtgt aggtcgttcg     2160

ctccaagctg ggctgtgtgc acgaaccccc cgttcagccc gaccgctgcg ccttatccgg     2220

taactatcgt cttgagtcca acccggtaag acacgactta tcgccactgg cagcagccac     2280

tggtaacagg attagcagag cgaggtatgt aggcggtgct acagagttct tgaagtggtg     2340

gcctaactac ggctacacta gaaggacagt atttggtatc tgcgctctgc tgaagccagt     2400

taccttcgga aaaagagttg gtagctcttg atccggcaaa caaaccaccg ctggtagcgg     2460

tggttttttt gtttgcaagc agcagattac gcgcagaaaa aaaggatctc aagaagatcc     2520

tttgatcttt tctacggggt ctgacgctca gtggaacgaa aactcacgtt aagggatttt     2580

ggtcatgaga ttatcaaaaa ggatcttcac ctagatcctt ttaaattaaa aatgaagttt     2640

taaatcaatc taaagtatat atgagtaaac ttggtctgac agttaccaat gcttaatcag     2700

tgaggcacct atctcagcga tctgtctatt tcgttcatcc atagttgcct gactccccgt     2760

cgtgtagata actacgatac gggagggctt accatctggc cccagtgctg caatgatacc     2820

gcgagaccca cgctcaccgg ctccagattt atcagcaata aaccagccag ccggaagggc     2880

cgagcgcaga agtggtcctg caactttatc cgcctccatc cagtctatta attgttgccg     2940

ggaagctaga gtaagtagtt cgccagttaa tagtttgcgc aacgttgttg ccattgctgc     3000

agccatgaga ttatcaaaaa ggatcttcac ctagatcctt ttcacgtaga aagccagtcc     3060

gcagaaacgg tgctgacccc ggatgaatgt cagctactgg gctatctgga caagggaaaa     3120

cgcaagcgca aagagaaagc aggtagcttg cagtgggctt acatggcgat agctagactg     3180

ggcggtttta tggacagcaa gcgaaccgga attgccagct ggggcgccct ctggtaaggt     3240

tgggaagccc tgcaaagtaa actggatggc tttcttgccg ccaaggatct gatggcgcag     3300

gggatcaagc tctgatcaag agacaggatg aggatcgttt cgcatgattg aacaagatgg     3360

attgcacgca ggttctccgg ccgcttgggt ggagaggcta ttcggctatg actgggcaca     3420

acagacaatc ggctgctctg atgccgccgt gttccggctg tcagcgcagg ggcgcccggt     3480

tctttttgtc aagaccgacc tgtccggtgc cctgaatgaa ctgcaagacg aggcagcgcg     3540

gctatcgtgg ctggccacga cgggcgttcc ttgcgcagct gtgctcgacg ttgtcactga     3600

agcgggaagg gactggctgc tattgggcga agtgccgggg caggatctcc tgtcatctca     3660

ccttgctcct gccgagaaag tatccatcat ggctgatgca atgcggcggc tgcatacgct     3720

tgatccggct acctgcccat tcgaccacca agcgaaacat cgcatcgagc gagcacgtac     3780

tcggatggaa gccggtcttg tcgatcagga tgatctggac gaagagcatc aggggctcgc     3840

gccagccgaa ctgttcgcca ggctcaaggc gagcatgccc gacggcgagg atctcgtcgt     3900

gacccatggc gatgcctgct tgccgaatat catggtggaa aatggccgct tttctggatt     3960

catcgactgt ggccggctgg gtgtggcgga ccgctatcag gacatagcgt tggctacccg     4020

tgatattgct gaagagcttg gcggcgaatg ggctgaccgc ttcctcgtgc tttacggtat     4080

cgccgctccc gattcgcagc gcatcgcctt ctatcgcctt cttgacgagt tcttctgaat     4140

tttgttaaaa tttttgttaa atcagctcat tttttaacca ataggccgaa atcggcaaaa     4200

tcccttataa atcaaaagaa tagaccgaga tagggttgag tgttgttcca gtttggaaca     4260

agagtccact attaaagaac gtggactcca acgtcaaagg gcgaaaaacc gtctatcagg     4320

gcgatggccc actacgtgaa ccatcaccct aatcaagttt tttggggtcg aggtgccgta     4380

aagcactaaa tcggaaccct aaagggagcc cccgatttag agcttgacgg ggaaagccgg     4440

cgaacgtggc gagaaaggaa gggaagaaag cgaaaggagc gggcgctagg gcgctggcaa     4500

gtgtagcggt cacgctgcgc gtaaccacca cacccgccgc gcttaatgcg ccgctacagg     4560

gcgcgtccat tcgccattca ggatcgaatt aattcttaat taacatcatc aataatatac     4620

cttattttgg attgaagcca atatgataat gagggggtgg agtttgtgac gtggcgcggg     4680

gcgtgggaac ggggcgggtg acgtagtagt gtggcggaag tgtgatgttg caagtgtggc     4740

ggaacacatg taagcgacgg atgtggcaaa agtgacgttt ttggtgtgcg ccggtgtaca     4800

caggaagtga caattttcgc gcggttttag gcggatgttg tagtaaattt gggcgtaacc     4860

gagtaagatt tggccatttt cgcgggaaaa ctgaataaga ggaagtgaaa tctgaataat     4920

tttgtgttac tcatagcgcg taatactgta atagtaatca attacggggt cattagttca     4980

tagcccatat atggagttcc gcgttacata acttacggta aatggcccgc ctggctgacc     5040

gcccaacgac ccccgcccat tgacgtcaat aatgacgtat gttcccatag taacgccaat     5100

agggactttc cattgacgtc aatgggtgga gtatttacgg taaactgccc acttggcagt     5160

acatcaagtg tatcatatgc caagtacgcc ccctattgac gtcaatgacg gtaaatggcc     5220

cgcctggcat tatgcccagt acatgacctt atgggacttt cctacttggc agtacatcta     5280

cgtattagtc atcgctatta ccatggtgat gcggttttgg cagtacatca atgggcgtgg     5340

atagcggttt gactcacggg gatttccaag tctccacccc attgacgtca atgggagttt     5400

gttttggcac caaaatcaac gggactttcc aaaatgtcgt aacaactccg ccccattgac     5460

gcaaatgggc ggtaggcgtg tacggtggga ggtctatata agcagagctg gtttagtgaa     5520

ccgtcagatc cgctagagat ctggtaccgt cgacgcggcc gctcgagcct aagcttatga     5580

gcagcagtag ttggcttctc ttgagtttgg tggcagtgac agcagcccag agtactatcg     5640

aggagcaggc taaatacttt ctggataagt ttaacgccga ggccgaagac ttgttctatc     5700

aatcttctct cgcttcatgg aattacaata ctaacatcac tgaggagaac gtccagaata     5760

tgaacaatgc tggcgacaaa tggagcgcct tcttgaagga gcagtctacc cttgcacaaa     5820

tgtatccact gcaggagata cagaacctta cagtaaagtt gcagctccag gctctccagc     5880

agaacggatc tagcgtgctt tcagaggata aaagcaaaag gctgaacacc atacttaata     5940

ccatgtccac aatttactct actggtaaag tatgtaaccc cgacaaccct caagaatgcc     6000

tccttcttga gccaggcctc aatgagatca tggctaatag tctggactat aatgaaagac     6060

tgtgggcatg ggagtcctgg agatctgaag tagggaagca actgaggccc ctttatgaag     6120

agtacgtcgt acttaagaat gaaatggccc gcgctaacca ctacgaggat tacggcgatt     6180

actggcgtgg ggactatgaa gtaaatggtg tagatggata cgactatagt cgtgggcaat     6240

tgattgagga tgtggagcac acttttgagg agataaaacc actctatgag catcttcacg     6300

catatgtgag agctaaactg atgaacgcct acccaagtta catcagtcca atcggatgtc     6360

tcccagctca cctccttggc gacatgtggg gacgtttctg gaccaatctg tattccctca     6420

cagtcccttt cgggcaaaag cctaatatag acgtgacaga cgcaatggtt gatcaggctt     6480

gggatgctca aaggattttt aaggaagctg agaagttttt tgtgtcagtc ggtttgccaa     6540

atatgacaca aggcttctgg gaaaatagca tgttgactga tcccggtaat gttcaaaagg     6600

ctgtgtgtgc ccctaccgct tgggaccttg ggaaaggtga ctttcgaatc ttgatgtgta     6660

ccaaggtgac aatggatgac tttcttacag cccatcatga aatgggtcac atccagtatg     6720

atatggctta tgcagctcaa cctttcctct tgagaaatgg tgcaaatgaa ggttttcatg     6780

aagctgtagg ggaaataatg tccctgagtg ctgcaacccc aaagcatctc aagagtatcg     6840

gattgttgag cccagatttt caagaagata acgagaccga aatcaacttc cttctgaaac     6900

aagccctcac aatagttggt actcttccat tcacatacat gctggagaaa tggcgttgga     6960

tggtttttaa gggggagata cctaaagatc agtggatgaa aaagtggtgg gagatgaagc     7020

gtgagatcgt aggggtcgtg gagccagtgc ctcatgatga gacttactgt gacccagcat     7080

cactcttcca cgttagcaat gactattcat ttatacgtta ttacactcgc actctttacc     7140

agtttcaatt tcaggaggct ctgtgtcagg ctgccaagca tgagggaccc cttcacaagt     7200

gtgatattag taacagtact gaggcaggcc aaaaactgtt caatatgttg aggcttggca     7260

aaagcgagcc atggactctc gccttggaaa atgttgtcgg ggctaaaaac atgaatgtac     7320

gccctctgct taactatttt gagccccttt ttacatggct caaggaccag aataagaact     7380

cctttgtcgg ctggtcaaca gactggtctc cctatgcaga ccctagtact cctcctactc     7440

cttctccatc aaccccacca actccatccc ctagctgctg tcacccaagg ctgtctctgc     7500

accgacctgc actcgaagac cttctgttgg gctctgaagc taacctgacc tgtactctta     7560

ctggcttgcg cgatgctagc ggcgtgactt tcacctggac acctagtagc ggtaaaagtg     7620

ctgtacaagg acctcctgaa cgcgacctgt gtggttgcta ctctgtgtct tctgtacttc     7680

ccggctgtgc cgagccctgg aatcacggga aaacctttac ctgcaccgcc gcttaccctg     7740

agtcaaaaac tcccctcact gccacattga gtaagtcagg gaatacattc aggccagagg     7800

ttcatttgtt gcctcctcca tctgaagaac ttgctttgaa cgagctggtc actctgacct     7860

gcttggctag gggtttctcc cccaaagatg tacttgtacg gtggttgcag ggcagccaag     7920

agttgccccg cgaaaagtat ttgacctggg cctcaagaca agaacccagc caggggacta     7980

ccacatttgc cgtgaccagt attctgcgtg tagccgctga agattggaag aaaggggata     8040

cattttcttg catggtaggg catgaggccc ttcccctcgc tttcactcag aagacaatag     8100

acagactcgc cggaaagcct actcacgtga atgttagcgt agtcatggct gaggttgacg     8160

gaacttgcta ctgagatatc cgatccaccg gatctagata actgatcata atcagccata     8220

ccacatttgt agaggtttta cttgctttaa aaaacctccc acacctcccc ctgaacctga     8280

aacataaaat gaatgcaatt gttgttgtta acttgtttat tgcagcttat aatggttaca     8340

aataaagcaa tagcatcaca aatttcacaa ataaagcatt tttttcactg cattctagtt     8400

gtggtttgtc caaactcatc aatgtatctt aggtttagtg aaccgtcaga tccgctagcg     8460

ttacataact tacggtaaat ggcccgcctg gctgaccgcc caacgacccc cgcccattga     8520

cgtcaataat gacgtatgtt cccatagtaa cgccaatagg gactttccat tgacgtcaat     8580

gggtggagta tttacggtaa actgcccact tggcagtaca tcaagtgtat catatgccaa     8640

gtacgccccc tattgacgtc aatgacggta aatggcccgc ctggcattat gcccagtaca     8700

tgaccttatg ggactttcct acttggcagt acatctacgt attagtcatc gctattacca     8760

tggtgatgcg gttttggcag tacatcaatg ggcgtggata gcggtttgac tcacggggat     8820

ttccaagtct ccaccccatt gacgtcaatg ggagtttgtt ttggcaccaa aatcaacggg     8880

actttccaaa atgtcgtaac aactccgccc cattgacgca aatgggcggt aggcgtgtac     8940

ggtgggaggt ctatataagc agagctggtt tagtgaaccg tcagatccgc tagagatctg     9000

gtaccgtcga cgcggccgct cgagcctaag cttatgaaga accatctgct tttctgggga     9060

gtacttgccg ttttcataaa agccgtacat gttaaagcac aagaggacga acgcattgtg     9120

ttggttgata ataaatgcaa atgtgctcgg ataacatctc ggatcattcg tagctcagag     9180

gaccccaatg aggatatagt agagcgaaac atcagaatta tagtacccct gaacaacaga     9240

gagaacataa gtgatcccac aagtccattg cggacacgct ttgtttacca tttgtctgat     9300

ctgtgtaaaa aatgtgatcc aacagaggtg gaactcgaca atcagatcgt caccgccacc     9360

cagtctaaca tctgcgatga agattcagct acagagacat gctacacata cgaccggaac     9420

aagtgctata ctgccgttgt gccactcgtt tacggtggag aaacaaagat ggttgaaact     9480

gcacttacac cagatgcctg ctatccagat tgagatatcc gatccaccgg atctagataa     9540

ctgatcataa tcagccatac cacatttgta gaggttttac ttgctttaaa aaacctccca     9600

cacctccccc tgaacctgaa acataaaatg aatgcaattg ttgttgttaa cttgtttatt     9660

gcagcttata atggttacaa ataaagcaat agcatcacaa atttcacaaa taaagcattt     9720

ttttcactgc attctagttg tggtttgtcc aaactcatca atgtatctta acgcggatct     9780

gggcgtggtt aagggtggga aagaatatat aaggtggggg tcttatgtag ttttgtatct     9840

gttttgcagc agccgccgcc gccatgagca ccaactcgtt tgatggaagc attgtgagct     9900

catatttgac aacgcgcatg cccccatggg ccggggtgcg tcagaatgtg atgggctcca     9960

gcattgatgg tcgccccgtc ctgcccgcaa actctactac cttgacctac gagaccgtgt    10020

ctggaacgcc gttggagact gcagcctccg ccgccgcttc agccgctgca gccaccgccc    10080

gcgggattgt gactgacttt gctttcctga gcccgcttgc aagcagtgca gcttcccgtt    10140

catccgcccg cgatgacaag ttgacggctc ttttggcaca attggattct ttgacccggg    10200

aacttaatgt cgtttctcag cagctgttgg atctgcgcca gcaggtttct gccctgaagg    10260

cttcctcccc tcccaatgcg gtttaaaaca taaataaaaa accagactct gtttggattt    10320

ggatcaagca agtgtcttgc tgtctttatt taggggtttt gcgcgcgcgg taggcccggg    10380

accagcggtc tcggtcgttg agggtcctgt gtattttttc caggacgtgg taaaggtgac    10440

tctggatgtt cagatacatg ggcataagcc cgtctctggg gtggaggtag caccactgca    10500

gagcttcatg ctgcggggtg gtgttgtaga tgatccagtc gtagcaggag cgctgggcgt    10560

ggtgcctaaa aatgtctttc agtagcaagc tgattgccag gggcaggccc ttggtgtaag    10620

tgtttacaaa gcggttaagc tgggatgggt gcatacgtgg ggatatgaga tgcatcttgg    10680

actgtatttt taggttggct atgttcccag ccatatccct ccggggattc atgttgtgca    10740

gaaccaccag cacagtgtat ccggtgcact tgggaaattt gtcatgtagc ttagaaggaa    10800

atgcgtggaa gaacttggag acgcccttgt gacctccaag attttccatg cattcgtcca    10860

taatgatggc aatgggccca cgggcggcgg cctgggcgaa gatatttctg ggatcactaa    10920

cgtcatagtt gtgttccagg atgagatcgt cataggccat ttttacaaag cgcgggcgga    10980

gggtgccaga ctgcggtata atggttccat ccggcccagg ggcgtagtta ccctcacaga    11040

tttgcatttc ccacgctttg agttcagatg gggggatcat gtctacctgc ggggcgatga    11100

agaaaacggt ttccggggta ggggagatca gctgggaaga aagcaggttc ctgagcagct    11160

gcgacttacc gcagccggtg ggcccgtaaa tcacacctat taccggctgc aactggtagt    11220

taagagagct gcagctgccg tcatccctga gcaggggggc cacttcgtta agcatgtccc    11280

tgactcgcat gttttccctg accaaatccg ccagaaggcg ctcgccgccc agcgatagca    11340

gttcttgcaa ggaagcaaag tttttcaacg gtttgagacc gtccgccgta ggcatgcttt    11400

tgagcgtttg accaagcagt tccaggcggt cccacagctc ggtcacctgc tctacggcat    11460

ctcgatccag catatctcct cgtttcgcgg gttggggcgg ctttcgctgt acggcagtag    11520

tcggtgctcg tccagacggg ccagggtcat gtctttccac gggcgcaggg tcctcgtcag    11580

cgtagtctgg gtcacggtga aggggtgcgc tccgggctgc gcgctggcca gggtgcgctt    11640

gaggctggtc ctgctggtgc tgaagcgctg ccggtcttcg ccctgcgcgt cggccaggta    11700

gcatttgacc atggtgtcat agtccagccc ctccgcggcg tggcccttgg cgcgcagctt    11760

gcccttggag gaggcgccgc acgaggggca gtgcagactt ttgagggcgt agagcttggg    11820

cgcgagaaat accgattccg gggagtaggc atccgcgccg caggccccgc agacggtctc    11880

gcattccacg agccaggtga gctctggccg ttcggggtca aaaaccaggt ttcccccatg    11940

ctttttgatg cgtttcttac ctctggtttc catgagccgg tgtccacgct cggtgacgaa    12000

aaggctgtcc gtgtccccgt atacagactt gagaggcctg tcctcgagcg gtgttccgcg    12060

gtcctcctcg tatagaaact cggaccactc tgagacaaag gctcgcgtcc aggccagcac    12120

gaaggaggct aagtgggagg ggtagcggtc gttgtccact agggggtcca ctcgctccag    12180

ggtgtgaaga cacatgtcgc cctcttcggc atcaaggaag gtgattggtt tgtaggtgta    12240

ggccacgtga ccgggtgttc ctgaaggggg gctataaaag ggggtggggg cgcgttcgtc    12300

ctcactctct tccgcatcgc tgtctgcgag ggccagctgt tggggtgagt actccctctg    12360

aaaagcgggc atgacttctg cgctaagatt gtcagtttcc aaaaacgagg aggatttgat    12420

attcacctgg cccgcggtga tgcctttgag ggtggccgca tccatctggt cagaaaagac    12480

aatctttttg ttgtcaagct tggtggcaaa cgacccgtag agggcgttgg acagcaactt    12540

ggcgatggag cgcagggttt ggtttttgtc gcgatcggcg cgctccttgg ccgcgatgtt    12600

tagctgcacg tattcgcgcg caacgcaccg ccattcggga aagacggtgg tgcgctcgtc    12660

gggcaccagg tgcacgcgcc aaccgcggtt gtgcagggtg acaaggtcaa cgctggtggc    12720

tacctctccg cgtaggcgct cgttggtcca gcagaggcgg ccgcccttgc gcgagcagaa    12780

tggcggtagg gggtctagct gcgtctcgtc cggggggtct gcgtccacgg taaagacccc    12840

gggcagcagg cgcgcgtcga agtagtctat cttgcatcct tgcaagtcta gcgcctgctg    12900

ccatgcgcgg gcggcaagcg cgcgctcgta tgggttgagt gggggacccc atggcatggg    12960

gtgggtgagc gcggaggcgt acatgccgca aatgtcgtaa acgtagaggg gctctctgag    13020

tattccaaga tatgtagggt agcatcttcc accgcggatg ctggcgcgca cgtaatcgta    13080

tagttcgtgc gagggagcga ggaggtcggg accgaggttg ctacgggcgg gctgctctgc    13140

tcggaagact atctgcctga agatggcatg tgagttggat gatatggttg gacgctggaa    13200

gacgttgaag ctggcgtctg tgagacctac cgcgtcacgc acgaaggagg cgtaggagtc    13260

gcgcagcttg ttgaccagct cggcggtgac ctgcacgtct agggcgcagt agtccagggt    13320

ttccttgatg atgtcatact tatcctgtcc cttttttttc cacagctcgc ggttgaggac    13380

aaactcttcg cggtctttcc agtactcttg gatcggaaac ccgtcggcct ccgaacggta    13440

agagcctagc atgtagaact ggttgacggc ctggtaggcg cagcatccct tttctacggg    13500

tagcgcgtat gcctgcgcgg ccttccggca tgaccagcat gaagggcacg agctgcttcc    13560

caaaggcccc catccaagta taggtctcta catcgtaggt gacaaagaga cgctcggtgc    13620

gaggatgcga gccgatcggg aagaactgga tctcccgcca ccaattggag gagtggctat    13680

tgatgtggtg aaagtagaag tccctgcgac gggccgaaca ctcgtgctgg cttttgtaaa    13740

aacgtgcgca gtactggcag cggtgcacgg gctgtacatc ctgcacgagg ttgacctgac    13800

gaccgcgcac aaggaagcag agtgggaatt tgagcccctc gcctggcggg tttggctggt    13860

ggtcttctac ttcggctgct tgtccttgac cgtctggctg ctcgagggga gttacggtgg    13920

atcggaccac cacgccgcgc gagcccaaag tccagatgtc cgcgcgcggc ggtcggagct    13980

tgatgacaac atcgcgcaga tgggagctgt ccatggtctg gagctcccgc ggcgtcaggt    14040

caggcgggag ctcctgcagg tttacctcgc atagacgggt cagggcgcgg gctagatcca    14100

ggtgatacct aatttccagg ggctggttgg tggcggcgtc gatggcttgc aagaggccgc    14160

atccccgcgg cgcgactacg gtaccgcgcg gcgggcggtg ggccgcgggg gtgtccttgg    14220

atgatgcatc taaaagcggt gacgcgggcg agcccccgga ggtagggggg gctccggacc    14280

cgccgggaga gggggcaggg gcacgtcggc gccgcgcgcg ggcaggagct ggtgctgcgc    14340

gcgtaggttg ctggcgaacg cgacgacgcg gcggttgatc tcctgaatct ggcgcctctg    14400

cgtgaagacg acgggcccgg tgagcttgaa cctgaaagag agttcgacag aatcaatttc    14460

ggtgtcgttg acggcggcct ggcgcaaaat ctcctgcacg tctcctgagt tgtcttgata    14520

ggcgatctcg gccatgaact gctcgatctc ttcctcctgg agatctccgc gtccggctcg    14580

ctccacggtg gcggcgaggt cgttggaaat gcgggccatg agctgcgaga aggcgttgag    14640

gcctccctcg ttccagacgc ggctgtagac cacgccccct tcggcatcgc gggcgcgcat    14700

gaccacctgc gcgagattga gctccacgtg ccgggcgaag acggcgtagt ttcgcaggcg    14760

ctgaaagagg tagttgaggg tggtggcggt gtgttctgcc acgaagaagt acataaccca    14820

gcgtcgcaac gtggattcgt tgataattgt tgtgtaggta ctccgccgcc gagggacctg    14880

agcgagtccg catcgaccgg atcggaaaac ctctcgagaa aggcgtctaa ccagtcacag    14940

tcgcaaggta ggctgagcac cgtggcgggc ggcagcgggc ggcggtcggg gttgtttctg    15000

gcggaggtgc tgctgatgat gtaattaaag taggcggtct tgagacggcg gatggtcgac    15060

agaagcacca tgtccttggg tccggcctgc tgaatgcgca ggcggtcggc catgccccag    15120

gcttcgtttt gacatcggcg caggtctttg tagtagtctt gcatgagcct ttctaccggc    15180

acttcttctt ctccttcctc ttgtcctgca tctcttgcat ctatcgctgc ggcggcggcg    15240

gagtttggcc gtaggtggcg ccctcttcct cccatgcgtg tgaccccgaa gcccctcatc    15300

ggctgaagca gggctaggtc ggcgacaacg cgctcggcta atatggcctg ctgcacctgc    15360

gtgagggtag actggaagtc atccatgtcc acaaagcggt ggtatgcgcc cgtgttgatg    15420

gtgtaagtgc agttggccat aacggaccag ttaacggtct ggtgacccgg ctgcgagagc    15480

tcggtgtacc tgagacgcga gtaagccctc gagtcaaata cgtagtcgtt gcaagtccgc    15540

accaggtact ggtatcccac caaaaagtgc ggcggcggct ggcggtagag gggccagcgt    15600

agggtggccg gggctccggg ggcgagatct tccaacataa ggcgatgata tccgtagatg    15660

tacctggaca tccaggtgat gccggcggcg gtggtggagg cgcgcggaaa gtcgcggacg    15720

cggttccaga tgttgcgcag cggcaaaaag tgctccatgg tcgggacgct ctggccggtc    15780

aggcgcgcgc aatcgttgac gctctagcgt gcaaaaggag agcctgtaag cgggcactct    15840

tccgtggtct ggtggataaa ttcgcaaggg tatcatggcg gacgaccggg gttcgagccc    15900

cgtatccggc cgtccgccgt gatccatgcg gttaccgccc gcgtgtcgaa cccaggtgtg    15960

cgacgtcaga caacggggga gtgctccttt tggcttcctt ccaggcgcgg cggctgctgc    16020

gctagctttt ttggccactg gccgcgcgca gcgtaagcgg ttaggctgga aagcgaaagc    16080

attaagtggc tcgctccctg tagccggagg gttattttcc aagggttgag tcgcgggacc    16140

cccggttcga gtctcggacc ggccggactg cggcgaacgg gggtttgcct ccccgtcatg    16200

caagaccccg cttgcaaatt cctccggaaa cagggacgag cccctttttt gcttttccca    16260

gatgcatccg gtgctgcggc agatgcgccc ccctcctcag cagcggcaag agcaagagca    16320

gcggcagaca tgcagggcac cctcccctcc tcctaccgcg tcaggagggg cgacatccgc    16380

ggttgacgcg gcagcagatg gtgattacga acccccgcgg cgccgggccc ggcactacct    16440

ggacttggag gagggcgagg gcctggcgcg gctaggagcg ccctctcctg agcggcaccc    16500

aagggtgcag ctgaagcgtg atacgcgtga ggcgtacgtg ccgcggcaga acctgtttcg    16560

cgaccgcgag ggagaggagc ccgaggagat gcgggatcga aagttccacg cagggcgcga    16620

gctgcggcat ggcctgaatc gcgagcggtt gctgcgcgag gaggactttg agcccgacgc    16680

gcgaaccggg attagtcccg cgcgcgcaca cgtggcggcc gccgacctgg taaccgcata    16740

cgagcagacg gtgaaccagg agattaactt tcaaaaaagc tttaacaacc acgtgcgtac    16800

gcttgtggcg cgcgaggagg tggctatagg actgatgcat ctgtgggact ttgtaagcgc    16860

gctggagcaa aacccaaata gcaagccgct catggcgcag ctgttcctta tagtgcagca    16920

cagcagggac aacgaggcat tcagggatgc gctgctaaac atagtagagc ccgagggccg    16980

ctggctgctc gatttgataa acatcctgca gagcatagtg gtgcaggagc gcagcttgag    17040

cctggctgac aaggtggccg ccatcaacta ttccatgctt agcctgggca agttttacgc    17100

ccgcaagata taccataccc cttacgttcc catagacaag gaggtaaaga tcgaggggtt    17160

ctacatgcgc atggcgctga aggtgcttac cttgagcgac gacctgggcg tttatcgcaa    17220

cgagcgcatc cacaaggccg tgagcgtgag ccggcggcgc gagctcagcg accgcgagct    17280

gatgcacagc ctgcaaaggg ccctggctgg cacgggcagc ggcgatagag aggccgagtc    17340

ctactttgac gcgggcgctg acctgcgctg ggccccaagc cgacgcgccc tggaggcagc    17400

tggggccgga cctgggctgg cggtggcacc cgcgcgcgct ggcaacgtcg gcggcgtgga    17460

ggaatatgac gaggacgatg agtacgagcc agaggacggc gagtactaag cggtgatgtt    17520

tctgatcaga tgatgcaaga cgcaacggac ccggcggtgc gggcggcgct gcagagccag    17580

ccgtccggcc ttaactccac ggacgactgg cgccaggtca tggaccgcat catgtcgctg    17640

actgcgcgca atcctgacgc gttccggcag cagccgcagg ccaaccggct ctccgcaatt    17700

ctggaagcgg tggtcccggc gcgcgcaaac cccacgcacg agaaggtgct ggcgatcgta    17760

aacgcgctgg ccgaaaacag ggccatccgg cccgacgagg ccggcctggt ctacgacgcg    17820

ctgcttcagc gcgtggctcg ttacaacagc ggcaacgtgc agaccaacct ggaccggctg    17880

gtgggggatg tgcgcgaggc cgtggcgcag cgtgagcgcg cgcagcagca gggcaacctg    17940

ggctccatgg ttgcactaaa cgccttcctg agtacacagc ccgccaacgt gccgcgggga    18000

caggaggact acaccaactt tgtgagcgca ctgcggctaa tggtgactga gacaccgcaa    18060

agtgaggtgt accagtctgg gccagactat tttttccaga ccagtagaca aggcctgcag    18120

accgtaaacc tgagccaggc tttcaaaaac ttgcaggggc tgtggggggt gcgggctccc    18180

acaggcgacc gcgcgaccgt gtctagcttg ctgacgccca actcgcgcct gttgctgctg    18240

ctaatagcgc ccttcacgga cagtggcagc gtgtcccggg acacatacct aggtcacttg    18300

ctgacactgt accgcgaggc cataggtcag gcgcatgtgg acgagcatac tttccaggag    18360

attacaagtg tcagccgcgc gctggggcag gaggacacgg gcagcctgga ggcaacccta    18420

aactacctgc tgaccaaccg gcggcagaag atcccctcgt tgcacagttt aaacagcgag    18480

gaggagcgca ttttgcgcta cgtgcagcag agcgtgagcc ttaacctgat gcgcgacggg    18540

gtaacgccca gcgtggcgct ggacatgacc gcgcgcaaca tggaaccggg catgtatgcc    18600

tcaaaccggc cgtttatcaa ccgcctaatg gactacttgc atcgcgcggc cgccgtgaac    18660

cccgagtatt tcaccaatgc catcttgaac ccgcactggc taccgccccc tggtttctac    18720

accgggggat tcgaggtgcc cgagggtaac gatggattcc tctgggacga catagacgac    18780

agcgtgtttt ccccgcaacc gcagaccctg ctagagttgc aacagcgcga gcaggcagag    18840

gcggcgctgc gaaaggaaag cttccgcagg ccaagcagct tgtccgatct aggcgctgcg    18900

gccccgcggt cagatgctag tagcccattt ccaagcttga tagggtctct taccagcact    18960

cgcaccaccc gcccgcgcct gctgggcgag gaggagtacc taaacaactc gctgctgcag    19020

ccgcagcgcg aaaaaaacct gcctccggca tttcccaaca acgggataga gagcctagtg    19080

gacaagatga gtagatggaa gacgtacgcg caggagcaca gggacgtgcc aggcccgcgc    19140

ccgcccaccc gtcgtcaaag gcacgaccgt cagcggggtc tggtgtggga ggacgatgac    19200

tcggcagacg acagcagcgt cctggatttg ggagggagtg gcaacccgtt tgcgcacctt    19260

cgccccaggc tggggagaat gttttaaaaa aaaaaaagca tgatgcaaaa taaaaaactc    19320

accaaggcca tggcaccgag cgttggtttt cttgtattcc ccttagtatg cggcgcgcgg    19380

cgatgtatga ggaaggtcct cctccctcct acgagagtgt ggtgagcgcg gcgccagtgg    19440

cggcggcgct gggttctccc ttcgatgctc ccctggaccc gccgtttgtg cctccgcggt    19500

acctgcggcc taccgggggg agaaacagca tccgttactc tgagttggca cccctattcg    19560

acaccacccg tgtgtacctg gtggacaaca agtcaacgga tgtggcatcc ctgaactacc    19620

agaacgacca cagcaacttt ctgaccacgg tcattcaaaa caatgactac agcccggggg    19680

aggcaagcac acagaccatc aatcttgacg accggtcgca ctggggcggc gacctgaaaa    19740

ccatcctgca taccaacatg ccaaatgtga acgagttcat gtttaccaat aagtttaagg    19800

cgcgggtgat ggtgtcgcgc ttgcctacta aggacaatca ggtggagctg aaatacgagt    19860

gggtggagtt cacgctgccc gagggcaact actccgagac catgaccata gaccttatga    19920

acaacgcgat cgtggagcac tacttgaaag tgggcagaca gaacggggtt ctggaaagcg    19980

acatcggggt aaagtttgac acccgcaact tcagactggg gtttgacccc gtcactggtc    20040

ttgtcatgcc tggggtatat acaaacgaag ccttccatcc agacatcatt ttgctgccag    20100

gatgcggggt ggacttcacc cacagccgcc tgagcaactt gttgggcatc cgcaagcggc    20160

aacccttcca ggagggcttt aggatcacct acgatgatct ggagggtggt aacattcccg    20220

cactgttgga tgtggacgcc taccaggcga gcttgaaaga tgacaccgaa cagggcgggg    20280

gtggcgcagg cggcagcaac agcagtggca gcggcgcgga agagaactcc aacgcggcag    20340

ccgcggcaat gcagccggtg gaggacatga acgatcatgc cattcgcggc gacacctttg    20400

ccacacgggc tgaggagaag cgcgctgagg ccgaagcagc ggccgaagct gccgcccccg    20460

ctgcgcaacc cgaggtcgag aagcctcaga agaaaccggt gatcaaaccc ctgacagagg    20520

acagcaagaa acgcagttac aacctaataa gcaatgacag caccttcacc cagtaccgca    20580

gctggtacct tgcatacaac tacggcgacc ctcagaccgg aatccgctca tggaccctgc    20640

tttgcactcc tgacgtaacc tgcggctcgg agcaggtcta ctggtcgttg ccagacatga    20700

tgcaagaccc cgtgaccttc cgctccacgc gccagatcag caactttccg gtggtgggcg    20760

ccgagctgtt gcccgtgcac tccaagagct tctacaacga ccaggccgtc tactcccaac    20820

tcatccgcca gtttacctct ctgacccacg tgttcaatcg ctttcccgag aaccagattt    20880

tggcgcgccc gccagccccc accatcacca ccgtcagtga aaacgttcct gctctcacag    20940

atcacgggac gctaccgctg cgcaacagca tcggaggagt ccagcgagtg accattactg    21000

acgccagacg ccgcacctgc ccctacgttt acaaggccct gggcatagtc tcgccgcgcg    21060

tcctatcgag ccgcactttt tgagcaagca tgtccatcct tatatcgccc agcaataaca    21120

caggctgggg cctgcgcttc ccaagcaaga tgtttggcgg ggccaagaag cgctccgacc    21180

aacacccagt gcgcgtgcgc gggcactacc gcgcgccctg gggcgcgcac aaacgcggcc    21240

gcactgggcg caccaccgtc gatgacgcca tcgacgcggt ggtggaggag gcgcgcaact    21300

acacgcccac gccgccacca gtgtccacag tggacgcggc cattcagacc gtggtgcgcg    21360

gagcccggcg ctatgctaaa atgaagagac ggcggaggcg cgtagcacgt cgccaccgcc    21420

gccgacccgg cactgccgcc caacgcgcgg cggcggccct gcttaaccgc gcacgtcgca    21480

ccggccgacg ggcggccatg cgggccgctc gaaggctggc cgcgggtatt gtcactgtgc    21540

cccccaggtc caggcgacga gcggccgccg cagcagccgc ggccattagt gctatgactc    21600

agggtcgcag gggcaacgtg tattgggtgc gcgactcggt tagcggcctg cgcgtgcccg    21660

tgcgcacccg ccccccgcgc aactagattg caagaaaaaa ctacttagac tcgtactgtt    21720

gtatgtatcc agcggcggcg gcgcgcaacg aagctatgtc caagcgcaaa atcaaagaag    21780

agatgctcca ggtcatcgcg ccggagatct atggcccccc gaagaaggaa gagcaggatt    21840

acaagccccg aaagctaaag cgggtcaaaa agaaaaagaa agatgatgat gatgaacttg    21900

acgacgaggt ggaactgctg cacgctaccg cgcccaggcg acgggtacag tggaaaggtc    21960

gacgcgtaaa acgtgttttg cgacccggca ccaccgtagt ctttacgccc ggtgagcgct    22020

ccacccgcac ctacaagcgc gtgtatgatg aggtgtacgg cgacgaggac ctgcttgagc    22080

aggccaacga gcgcctcggg gagtttgcct acggaaagcg gcataaggac atgctggcgt    22140

tgccgctgga cgagggcaac ccaacaccta gcctaaagcc cgtaacactg cagcaggtgc    22200

tgcccgcgct tgcaccgtcc gaagaaaagc gcggcctaaa gcgcgagtct ggtgacttgg    22260

cacccaccgt gcagctgatg gtacccaagc gccagcgact ggaagatgtc ttggaaaaaa    22320

tgaccgtgga acctgggctg gagcccgagg tccgcgtgcg gccaatcaag caggtggcgc    22380

cgggactggg cgtgcagacc gtggacgttc agatacccac taccagtagc accagtattg    22440

ccaccgccac agagggcatg gagacacaaa cgtccccggt tgcctcagcg gtggcggatg    22500

ccgcggtgca ggcggtcgct gcggccgcgt ccaagacctc tacggaggtg caaacggacc    22560

cgtggatgtt tcgcgtttca gccccccggc gcccgcgccg ttcgaggaag tacggcgccg    22620

ccagcgcgct actgcccgaa tatgccctac atccttccat tgcgcctacc cccggctatc    22680

gtggctacac ctaccgcccc agaagacgag caactacccg acgccgaacc accactggaa    22740

cccgccgccg ccgtcgccgt cgccagcccg tgctggcccc gatttccgtg cgcagggtgg    22800

ctcgcgaagg aggcaggacc ctggtgctgc caacagcgcg ctaccacccc agcatcgttt    22860

aaaagccggt ctttgtggtt cttgcagata tggccctcac ctgccgcctc cgtttcccgg    22920

tgccgggatt ccgaggaaga atgcaccgta ggaggggcat ggccggccac ggcctgacgg    22980

gcggcatgcg tcgtgcgcac caccggcggc ggcgcgcgtc gcaccgtcgc atgcgcggcg    23040

gtatcctgcc cctccttatt ccactgatcg ccgcggcgat tggcgccgtg cccggaattg    23100

catccgtggc cttgcaggcg cagagacact gattaaaaac aagttgcatg tggaaaaatc    23160

aaaataaaaa gtctggactc tcacgctcgc ttggtcctgt aactattttg tagaatggaa    23220

gacatcaact ttgcgtctct ggccccgcga cacggctcgc gcccgttcat gggaaactgg    23280

caagatatcg gcaccagcaa tatgagcggt ggcgccttca gctggggctc gctgtggagc    23340

ggcattaaaa atttcggttc caccgttaag aactatggca gcaaggcctg gaacagcagc    23400

acaggccaga tgctgaggga taagttgaaa gagcaaaatt tccaacaaaa ggtggtagat    23460

ggcctggcct ctggcattag cggggtggtg gacctggcca accaggcagt gcaaaataag    23520

attaacagta agcttgatcc ccgccctccc gtagaggagc ctccaccggc cgtggagaca    23580

gtgtctccag aggggcgtgg cgaaaagcgt ccgcgccccg acagggaaga aactctggtg    23640

acgcaaatag acgagcctcc ctcgtacgag gaggcactaa agcaaggcct gcccaccacc    23700

cgtcccatcg cgcccatggc taccggagtg ctgggccagc acacacccgt aacgctggac    23760

ctgcctcccc ccgccgacac ccagcagaaa cctgtgctgc caggcccgac cgccgttgtt    23820

gtaacccgtc ctagccgcgc gtccctgcgc cgcgccgcca gcggtccgcg atcgttgcgg    23880

cccgtagcca gtggcaactg gcaaagcaca ctgaacagca tcgtgggtct gggggtgcaa    23940

tccctgaagc gccgacgatg cttctgatag ctaacgtgtc gtatgtgtgt catgtatgcg    24000

tccatgtcgc cgccagagga gctgctgagc cgccgcgcgc ccgctttcca agatggctac    24060

cccttcgatg atgccgcagt ggtcttacat gcacatctcg ggccaggacg cctcggagta    24120

cctgagcccc gggctggtgc agtttgcccg cgccaccgag acgtacttca gcctgaataa    24180

caagtttaga aaccccacgg tggcgcctac gcacgacgtg accacagacc ggtcccagcg    24240

tttgacgctg cggttcatcc ctgtggaccg tgaggatact gcgtactcgt acaaggcgcg    24300

gttcacccta gctgtgggtg ataaccgtgt gctggacatg gcttccacgt actttgacat    24360

ccgcggcgtg ctggacaggg gccctacttt taagccctac tctggcactg cctacaacgc    24420

cctggctccc aagggtgccc caaatccttg cgaatgggat gaagctgcta ctgctcttga    24480

aataaaccta gaagaagagg acgatgacaa cgaagacgaa gtagacgagc aagctgagca    24540

gcaaaaaact cacgtatttg ggcaggcgcc ttattctggt ataaatatta caaaggaggg    24600

tattcaaata ggtgtcgaag gtcaaacacc taaatatgcc gataaaacat ttcaacctga    24660

acctcaaata ggagaatctc agtggtacga aacagaaatt aatcatgcag ctgggagagt    24720

cctaaaaaag actaccccaa tgaaaccatg ttacggttca tatgcaaaac ccacaaatga    24780

aaatggaggg caaggcattc ttgtaaagca acaaaatgga aagctagaaa gtcaagtgga    24840

aatgcaattt ttctcaacta ctgaggcagc cgcaggcaat ggtgataact tgactcctaa    24900

agtggtattg tacagtgaag atgtagatat agaaacccca gacactcata tttcttacat    24960

gcccactatt aaggaaggta actcacgaga actaatgggc caacaatcta tgcccaacag    25020

gcctaattac attgctttta gggacaattt tattggtcta atgtattaca acagcacggg    25080

taatatgggt gttctggcgg gccaagcatc gcagttgaat gctgttgtag atttgcaaga    25140

cagaaacaca gagctttcat accagctttt gcttgattcc attggtgata gaaccaggta    25200

cttttctatg tggaatcagg ctgttgacag ctatgatcca gatgttagaa ttattgaaaa    25260

tcatggaact gaagatgaac ttccaaatta ctgctttcca ctgggaggtg tgattaatac    25320

agagactctt accaaggtaa aacctaaaac aggtcaggaa aatggatggg aaaaagatgc    25380

tacagaattt tcagataaaa atgaaataag agttggaaat aattttgcca tggaaatcaa    25440

tctaaatgcc aacctgtgga gaaatttcct gtactccaac atagcgctgt atttgcccga    25500

caagctaaag tacagtcctt ccaacgtaaa aatttctgat aacccaaaca cctacgacta    25560

catgaacaag cgagtggtgg ctcccgggct agtggactgc tacattaacc ttggagcacg    25620

ctggtccctt gactatatgg acaacgtcaa cccatttaac caccaccgca atgctggcct    25680

gcgctaccgc tcaatgttgc tgggcaatgg tcgctatgtg cccttccaca tccaggtgcc    25740

tcagaagttc tttgccatta aaaacctcct tctcctgccg ggctcataca cctacgagtg    25800

gaacttcagg aaggatgtta acatggttct gcagagctcc ctaggaaatg acctaagggt    25860

tgacggagcc agcattaagt ttgatagcat ttgcctttac gccaccttct tccccatggc    25920

ccacaacacc gcctccacgc ttgaggccat gcttagaaac gacaccaacg accagtcctt    25980

taacgactat ctctccgccg ccaacatgct ctaccctata cccgccaacg ctaccaacgt    26040

gcccatatcc atcccctccc gcaactgggc ggctttccgc ggctgggcct tcacgcgcct    26100

taagactaag gaaaccccat cactgggctc gggctacgac ccttattaca cctactctgg    26160

ctctataccc tacctagatg gaacctttta cctcaaccac acctttaaga aggtggccat    26220

tacctttgac tcttctgtca gctggcctgg caatgaccgc ctgcttaccc ccaacgagtt    26280

tgaaattaag cgctcagttg acggggaggg ttacaacgtt gcccagtgta acatgaccaa    26340

agactggttc ctggtacaaa tgctagctaa ctataacatt ggctaccagg gcttctatat    26400

cccagagagc tacaaggacc gcatgtactc cttctttaga aacttccagc ccatgagccg    26460

tcaggtggtg gatgatacta aatacaagga ctaccaacag gtgggcatcc tacaccaaca    26520

caacaactct ggatttgttg gctaccttgc ccccaccatg cgcgaaggac aggcctaccc    26580

tgctaacttc ccctatccgc ttataggcaa gaccgcagtt gacagcatta cccagaaaaa    26640

gtttctttgc gatcgcaccc tttggcgcat cccattctcc agtaacttta tgtccatggg    26700

cgcactcaca gacctgggcc aaaaccttct ctacgccaac tccgcccacg cgctagacat    26760

gacttttgag gtggatccca tggacgagcc cacccttctt tatgttttgt ttgaagtctt    26820

tgacgtggtc cgtgtgcacc agccgcaccg cggcgtcatc gaaaccgtgt acctgcgcac    26880

gcccttctcg gccggcaacg ccacaacata aagaagcaag caacatcaac aacagctgcc    26940

gccatgggct ccagtgagca ggaactgaaa gccattgtca aagatcttgg ttgtgggcca    27000

tattttttgg gcacctatga caagcgcttt ccaggctttg tttctccaca caagctcgcc    27060

tgcgccatag tcaatacggc cggtcgcgag actgggggcg tacactggat ggcctttgcc    27120

tggaacccgc actcaaaaac atgctacctc tttgagccct ttggcttttc tgaccagcga    27180

ctcaagcagg tttaccagtt tgagtacgag tcactcctgc gccgtagcgc cattgcttct    27240

tcccccgacc gctgtataac gctggaaaag tccacccaaa gcgtacaggg gcccaactcg    27300

gccgcctgtg gactattctg ctgcatgttt ctccacgcct ttgccaactg gccccaaact    27360

cccatggatc acaaccccac catgaacctt attaccgggg tacccaactc catgctcaac    27420

agtccccagg tacagcccac cctgcgtcgc aaccaggaac agctctacag cttcctggag    27480

cgccactcgc cctacttccg cagccacagt gcgcagatta ggagcgccac ttctttttgt    27540

cacttgaaaa acatgtaaaa ataatgtact agagacactt tcaataaagg caaatgcttt    27600

tatttgtaca ctctcgggtg attatttacc cccacccttg ccgtctgcgc cgtttaaaaa    27660

tcaaaggggt tctgccgcgc atcgctatgc gccactggca gggacacgtt gcgatactgg    27720

tgtttagtgc tccacttaaa ctcaggcaca accatccgcg gcagctcggt gaagttttca    27780

ctccacaggc tgcgcaccat caccaacgcg tttagcaggt cgggcgccga tatcttgaag    27840

tcgcagttgg ggcctccgcc ctgcgcgcgc gagttgcgat acacagggtt gcagcactgg    27900

aacactatca gcgccgggtg gtgcacgctg gccagcacgc tcttgtcgga gatcagatcc    27960

gcgtccaggt cctccgcgtt gctcagggcg aacggagtca actttggtag ctgccttccc    28020

aaaaagggcg cgtgcccagg ctttgagttg cactcgcacc gtagtggcat caaaaggtga    28080

ccgtgcccgg tctgggcgtt aggatacagc gcctgcataa aagccttgat ctgcttaaaa    28140

gccacctgag cctttgcgcc ttcagagaag aacatgccgc aagacttgcc ggaaaactga    28200

ttggccggac aggccgcgtc gtgcacgcag caccttgcgt cggtgttgga gatctgcacc    28260

acatttcggc cccaccggtt cttcacgatc ttggccttgc tagactgctc cttcagcgcg    28320

cgctgcccgt tttcgctcgt cacatccatt tcaatcacgt gctccttatt tatcataatg    28380

cttccgtgta gacacttaag ctcgccttcg atctcagcgc agcggtgcag ccacaacgcg    28440

cagcccgtgg gctcgtgatg cttgtaggtc acctctgcaa acgactgcag gtacgcctgc    28500

aggaatcgcc ccatcatcgt cacaaaggtc ttgttgctgg tgaaggtcag ctgcaacccg    28560

cggtgctcct cgttcagcca ggtcttgcat acggccgcca gagcttccac ttggtcaggc    28620

agtagtttga agttcgcctt tagatcgtta tccacgtggt acttgtccat cagcgcgcgc    28680

gcagcctcca tgcccttctc ccacgcagac acgatcggca cactcagcgg gttcatcacc    28740

gtaatttcac tttccgcttc gctgggctct tcctcttcct cttgcgtccg cataccacgc    28800

gccactgggt cgtcttcatt cagccgccgc actgtgcgct tacctccttt gccatgcttg    28860

attagcaccg gtgggttgct gaaacccacc atttgtagcg ccacatcttc tctttcttcc    28920

tcgctgtcca cgattacctc tggtgatggc gggcgctcgg gcttgggaga agggcgcttc    28980

tttttcttct tgggcgcaat ggccaaatcc gccgccgagg tcgatggccg cgggctgggt    29040

gtgcgcggca ccagcgcgtc ttgtgatgag tcttcctcgt cctcggactc gatacgccgc    29100

ctcatccgct tttttggggg cgcccgggga ggcggcggcg acggggacgg ggacgacacg    29160

tcctccatgg ttgggggacg tcgcgccgca ccgcgtccgc gctcgggggt ggtttcgcgc    29220

tgctcctctt cccgactggc catttccttc tcctataggc agaaaaagat catggagtca    29280

gtcgagaaga aggacagcct aaccgccccc tctgagttcg ccaccaccgc ctccaccgat    29340

gccgccaacg cgcctaccac cttccccgtc gaggcacccc cgcttgagga ggaggaagtg    29400

attatcgagc aggacccagg ttttgtaagc gaagacgacg aggaccgctc agtaccaaca    29460

gaggataaaa agcaagacca ggacaacgca gaggcaaacg aggaacaagt cgggcggggg    29520

gacgaaaggc atggcgacta cctagatgtg ggagacgacg tgctgttgaa gcatctgcag    29580

cgccagtgcg ccattatctg cgacgcgttg caagagcgca gcgatgtgcc cctcgccata    29640

gcggatgtca gccttgccta cgaacgccac ctattctcac cgcgcgtacc ccccaaacgc    29700

caagaaaacg gcacatgcga gcccaacccg cgcctcaact tctaccccgt atttgccgtg    29760

ccagaggtgc ttgccaccta tcacatcttt ttccaaaact gcaagatacc cctatcctgc    29820

cgtgccaacc gcagccgagc ggacaagcag ctggccttgc ggcagggcgc tgtcatacct    29880

gatatcgcct cgctcaacga agtgccaaaa atctttgagg gtcttggacg cgacgagaag    29940

cgcgcggcaa acgctctgca acaggaaaac agcgaaaatg aaagtcactc tggagtgttg    30000

gtggaactcg agggtgacaa cgcgcgccta gccgtactaa aacgcagcat cgaggtcacc    30060

cactttgcct acccggcact taacctaccc cccaaggtca tgagcacagt catgagtgag    30120

ctgatcgtgc gccgtgcgca gcccctggag agggatgcaa atttgcaaga acaaacagag    30180

gagggcctac ccgcagttgg cgacgagcag ctagcgcgct ggcttcaaac gcgcgagcct    30240

gccgacttgg aggagcgacg caaactaatg atggccgcag tgctcgttac cgtggagctt    30300

gagtgcatgc agcggttctt tgctgacccg gagatgcagc gcaagctaga ggaaacattg    30360

cactacacct ttcgacaggg ctacgtacgc caggcctgca agatctccaa cgtggagctc    30420

tgcaacctgg tctcctacct tggaattttg cacgaaaacc gccttgggca aaacgtgctt    30480

cattccacgc tcaagggcga ggcgcgccgc gactacgtcc gcgactgcgt ttacttattt    30540

ctatgctaca cctggcagac ggccatgggc gtttggcagc agtgcttgga ggagtgcaac    30600

ctcaaggagc tgcagaaact gctaaagcaa aacttgaagg acctatggac ggccttcaac    30660

gagcgctccg tggccgcgca cctggcggac atcattttcc ccgaacgcct gcttaaaacc    30720

ctgcaacagg gtctgccaga cttcaccagt caaagcatgt tgcagaactt taggaacttt    30780

atcctagagc gctcaggaat cttgcccgcc acctgctgtg cacttcctag cgactttgtg    30840

cccattaagt accgcgaatg ccctccgccg ctttggggcc actgctacct tctgcagcta    30900

gccaactacc ttgcctacca ctctgacata atggaagacg tgagcggtga cggtctactg    30960

gagtgtcact gtcgctgcaa cctatgcacc ccgcaccgct ccctggtttg caattcgcag    31020

ctgcttaacg aaagtcaaat tatcggtacc tttgagctgc agggtccctc gcctgacgaa    31080

aagtccgcgg ctccggggtt gaaactcact ccggggctgt ggacgtcggc ttaccttcgc    31140

aaatttgtac ctgaggacta ccacgcccac gagattaggt tctacgaaga ccaatcccgc    31200

ccgcctaatg cggagcttac cgcctgcgtc attacccagg gccacattct tggccaattg    31260

caagccatca acaaagcccg ccaagagttt ctgctacgaa agggacgggg ggtttacttg    31320

gacccccagt ccggcgagga gctcaaccca atccccccgc cgccgcagcc ctatcagcag    31380

cagccgcggg cccttgcttc ccaggatggc acccaaaaag aagctgcagc tgccgccgcc    31440

acccacggac gaggaggaat actgggacag tcaggcagag gaggttttgg acgaggagga    31500

ggaggacatg atggaagact gggagagcct agacgaggaa gcttccgagg tcgaagaggt    31560

gtcagacgaa acaccgtcac cctcggtcgc attcccctcg ccggcgcccc agaaatcggc    31620

aaccggttcc agcatggcta caacctccgc tcctcaggcg ccgccggcac tgcccgttcg    31680

ccgacccaac cgtagatggg acaccactgg aaccagggcc ggtaagtcca agcagccgcc    31740

gccgttagcc caagagcaac aacagcgcca aggctaccgc tcatggcgcg ggcacaagaa    31800

cgccatagtt gcttgcttgc aagactgtgg gggcaacatc tccttcgccc gccgctttct    31860

tctctaccat cacggcgtgg ccttcccccg taacatcctg cattactacc gtcatctcta    31920

cagcccatac tgcaccggcg gcagcggcag caacagcagc ggccacacag aagcaaaggc    31980

gaccggatag caagactctg acaaagccca agaaatccac agcggcggca gcagcaggag    32040

gaggagcgct gcgtctggcg cccaacgaac ccgtatcgac ccgcgagctt agaaacagga    32100

tttttcccac tctgtatgct atatttcaac agagcagggg ccaagaacaa gagctgaaaa    32160

taaaaaacag gtctctgcga tccctcaccc gcagctgcct gtatcacaaa agcgaagatc    32220

agcttcggcg cacgctggaa gacgcggagg ctctcttcag taaatactgc gcgctgactc    32280

ttaaggacta gtttcgcgcc ctttctcaaa tttaagcgcg aaaactacgt catctccagc    32340

ggccacaccc ggcgccagca cctgttgtca gcgccattat gagcaaggaa attcccacgc    32400

cctacatgtg gagttaccag ccacaaatgg gacttgcggc tggagctgcc caagactact    32460

caacccgaat aaactacatg agcgcgggac cccacatgat atcccgggtc aacggaatac    32520

gcgcccaccg aaaccgaatt ctcctggaac aggcggctat taccaccaca cctcgtaata    32580

accttaatcc ccgtagttgg cccgctgccc tggtgtacca ggaaagtccc gctcccacca    32640

ctgtggtact tcccagagac gcccaggccg aagttcagat gactaactca ggggcgcagc    32700

ttgcgggcgg ctttcgtcac agggtgcggt cgcccgggca gggtataact cacctgacaa    32760

tcagagggcg aggtattcag ctcaacgacg agtcggtgag ctcctcgctt ggtctccgtc    32820

cggacgggac atttcagatc ggcggcgccg gccgctcttc attcacgcct cgtcaggcaa    32880

tcctaactct gcagacctcg tcctctgagc cgcgctctgg aggcattgga actctgcaat    32940

ttattgagga gtttgtgcca tcggtctact ttaacccctt ctcgggacct cccggccact    33000

atccggatca atttattcct aactttgacg cggtaaagga ctcggcggac ggctacgact    33060

gaatgttaag tggagaggca gagcaactgc gcctgaaaca cctggtccac tgtcgccgcc    33120

acaagtgctt tgcccgcgac tccggtgagt tttgctactt tgaattgccc gaggatcata    33180

tcgagggccc ggcgcacggc gtccggctta ccgcccaggg agagcttgcc cgtagcctga    33240

ttcgggagtt tacccagcgc cccctgctag ttgagcggga caggggaccc tgtgttctca    33300

ctgtgatttg caactgtcct aaccctggat tacatcaaga tcctctagtt aatgtcaggt    33360

cgcctaagtc gattaactag agtacccggg gatcttattc cctttaacta ataaaaaaaa    33420

ataataaagc atcacttact taaaatcagt tagcaaattt ctgtccagtt tattcagcag    33480

cacctccttg ccctcctccc agctctggta ttgcagcttc ctcctggctg caaactttct    33540

ccacaatcta aatggaatgt cagtttcctc ctgttcctgt ccatccgcac ccactatctt    33600

catgttgttg cagatgaagc gcgcaagacc gtctgaagat accttcaacc ccgtgtatcc    33660

atatgacacg gaaaccggtc ctccaactgt gccttttctt actcctccct ttgtatcccc    33720

caatgggttt caagagagtc cccctggggt actctctttg cgcctatccg aacctctagt    33780

tacctccaat ggcatgcttg cgctcaaaat gggcaacggc ctctctctgg acgaggccgg    33840

caaccttacc tcccaaaatg taaccactgt gagcccacct ctcaaaaaaa ccaagtcaaa    33900

cataaacctg gaaatatctg cacccctcac agttacctca gaagccctaa ctgtggctgc    33960

cgccgcacct ctaatggtcg cgggcaacac actcaccatg caatcacagg ccccgctaac    34020

cgtgcacgac tccaaactta gcattgccac ccaaggaccc ctcacagtgt cagaaggaaa    34080

gctagccctg caaacatcag gccccctcac caccaccgat agcagtaccc ttactatcac    34140

tgcctcaccc cctctaacta ctgccactgg tagcttgggc attgacttga aagagcccat    34200

ttatacacaa aatggaaaac taggactaaa gtacggggct cctttgcatg taacagacga    34260

cctaaacact ttgaccgtag caactggtcc aggtgtgact attaataata cttccttgca    34320

aactaaagtt actggagcct tgggttttga ttcacaaggc aatatgcaac ttaatgtagc    34380

aggaggacta aggattgatt ctcaaaacag acgccttata cttgatgtta gttatccgtt    34440

tgatgctcaa aaccaactaa atctaagact aggacagggc cctcttttta taaactcagc    34500

ccacaacttg gatattaact acaacaaagg cctttacttg tttacagctt caaacaattc    34560

caaaaagctt gaggttaacc taagcactgc caaggggttg atgtttgacg ctacagccat    34620

agccattaat gcaggagatg ggcttgaatt tggttcacct aatgcaccaa acacaaatcc    34680

cctcaaaaca aaaattggcc atggcctaga atttgattca aacaaggcta tggttcctaa    34740

actaggaact ggccttagtt ttgacagcac aggtgccatt acagtaggaa acaaaaataa    34800

tgataagcta actttgtgga ccacaccagc tccatctcct aactgtagac taaatgcaga    34860

gaaagatgct aaactcactt tggtcttaac aaaatgtggc agtcaaatac ttgctacagt    34920

ttcagttttg gctgttaaag gcagtttggc tccaatatct ggaacagttc aaagtgctca    34980

tcttattata agatttgacg aaaatggagt gctactaaac aattccttcc tggacccaga    35040

atattggaac tttagaaatg gagatcttac tgaaggcaca gcctatacaa acgctgttgg    35100

atttatgcct aacctatcag cttatccaaa atctcacggt aaaactgcca aaagtaacat    35160

tgtcagtcaa gtttacttaa acggagacaa aactaaacct gtaacactaa ccattacact    35220

aaacggtaca caggaaacag gagacacaac tccaagtgca tactctatgt cattttcatg    35280

ggactggtct ggccacaact acattaatga aatatttgcc acatcctctt acactttttc    35340

atacattgcc caagaataaa gaatcgtttg tgttatgttt caacgtgttt atttttcaat    35400

tgcagaaaat ttcaagtcat ttttcattca gtagtatagc cccaccacca catagcttat    35460

acagatcacc gtaccttaat caaactcaca gaaccctagt attcaacctg ccacctccct    35520

cccaacacac agagtacaca gtcctttctc cccggctggc cttaaaaagc atcatatcat    35580

gggtaacaga catattctta ggtgttatat tccacacggt ttcctgtcga gccaaacgct    35640

catcagtgat attaataaac tccccgggca gctcacttaa gttcatgtcg ctgtccagct    35700

gctgagccac aggctgctgt ccaacttgcg gttgcttaac gggcggcgaa ggagaagtcc    35760

acgcctacat gggggtagag tcataatcgt gcatcaggat agggcggtgg tgctgcagca    35820

gcgcgcgaat aaactgctgc cgccgccgct ccgtcctgca ggaatacaac atggcagtgg    35880

tctcctcagc gatgattcgc accgcccgca gcataaggcg ccttgtcctc cgggcacagc    35940

agcgcaccct gatctcactt aaatcagcac agtaactgca gcacagcacc acaatattgt    36000

tcaaaatccc acagtgcaag gcgctgtatc caaagctcat ggcggggacc acagaaccca    36060

cgtggccatc ataccacaag cgcaggtaga ttaagtggcg acccctcata aacacgctgg    36120

acataaacat tacctctttt ggcatgttgt aattcaccac ctcccggtac catataaacc    36180

tctgattaaa catggcgcca tccaccacca tcctaaacca gctggccaaa acctgcccgc    36240

cggctataca ctgcagggaa ccgggactgg aacaatgaca gtggagagcc caggactcgt    36300

aaccatggat catcatgctc gtcatgatat caatgttggc acaacacagg cacacgtgca    36360

tacacttcct caggattaca agctcctccc gcgttagaac catatcccag ggaacaaccc    36420

attcctgaat cagcgtaaat cccacactgc agggaagacc tcgcacgtaa ctcacgttgt    36480

gcattgtcaa agtgttacat tcgggcagca gcggatgatc ctccagtatg gtagcgcggg    36540

tttctgtctc aaaaggaggt agacgatccc tactgtacgg agtgcgccga gacaaccgag    36600

atcgtgttgg tcgtagtgtc atgccaaatg gaacgccgga cgtagtcata tttcctgaag    36660

caaaaccagg tgcgggcgtg acaaacagat ctgcgtctcc ggtctcgccg cttagatcgc    36720

tctgtgtagt agttgtagta tatccactct ctcaaagcat ccaggcgccc cctggcttcg    36780

ggttctatgt aaactccttc atgcgccgct gccctgataa catccaccac cgcagaataa    36840

gccacaccca gccaacctac acattcgttc tgcgagtcac acacgggagg agcgggaaga    36900

gctggaagaa ccatgttttt ttttttattc caaaagatta tccaaaacct caaaatgaag    36960

atctattaag tgaacgcgct cccctccggt ggcgtggtca aactctacag ccaaagaaca    37020

gataatggca tttgtaagat gttgcacaat ggcttccaaa aggcaaacgg ccctcacgtc    37080

caagtggacg taaaggctaa acccttcagg gtgaatctcc tctataaaca ttccagcacc    37140

ttcaaccatg cccaaataat tctcatctcg ccaccttctc aatatatctc taagcaaatc    37200

ccgaatatta agtccggcca ttgtaaaaat ctgctccaga gcgccctcca ccttcagcct    37260

caagcagcga atcatgattg caaaaattca ggttcctcac agacctgtat aagattcaaa    37320

agcggaacat taacaaaaat accgcgatcc cgtaggtccc ttcgcagggc cagctgaaca    37380

taatcgtgca ggtctgcacg gaccagcgcg gccacttccc cgccaggaac catgacaaaa    37440

gaacccacac tgattatgac acgcatactc ggagctatgc taaccagcgt agccccgatg    37500

taagcttgtt gcatgggcgg cgatataaaa tgcaaggtgc tgctcaaaaa atcaggcaaa    37560

gcctcgcgca aaaaagaaag cacatcgtag tcatgctcat gcagataaag gcaggtaagc    37620

tccggaacca ccacagaaaa agacaccatt tttctctcaa acatgtctgc gggtttctgc    37680

ataaacacaa aataaaataa caaaaaaaca tttaaacatt agaagcctgt cttacaacag    37740

gaaaaacaac ccttataagc ataagacgga ctacggccat gccggcgtga ccgtaaaaaa    37800

actggtcacc gtgattaaaa agcaccaccg acagctcctc ggtcatgtcc ggagtcataa    37860

tgtaagactc ggtaaacaca tcaggttgat tcacatcggt cagtgctaaa aagcgaccga    37920

aatagcccgg gggaatacat acccgcaggc gtagagacaa cattacagcc cccataggag    37980

gtataacaaa attaatagga gagaaaaaca cataaacacc tgaaaaaccc tcctgcctag    38040

gcaaaatagc accctcccgc tccagaacaa catacagcgc ttccacagcg gcagccataa    38100

cagtcagcct taccagtaaa aaagaaaacc tattaaaaaa acaccactcg acacggcacc    38160

agctcaatca gtcacagtgt aaaaaagggc caagtgcaga gcgagtatat ataggactaa    38220

aaaatgacgt aacggttaaa gtccacaaaa aacacccaga aaaccgcacg cgaacctacg    38280

cccagaaacg aaagccaaaa aacccacaac ttcctcaaat cgtcacttcc gttttcccac    38340

gttacgtcac ttcccatttt aagaaaacta caattcccaa cacatacaag ttactccgcc    38400

ctaaaaccta cgtcacccgc cccgttccca cgccccgcgc cacgtcacaa actccacccc    38460

ctcattatca tattggcttc aatccaaaat aaggta                              38496


<210>  231
<211>  9701
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  vector for IgG1 against T27Y H34A H345A ACE2 mutant


<220>
<221>  misc_feature
<222>  (2929)..(2930)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (2934)..(2934)
<223>  n is a, c, g, or t

<400>  231
ggcgtaatct gctgcttgca aacaaaaaaa ccaccgctac cagcggtggt ttgtttgccg       60

gatcaagagc taccaactct ttttccgaag gtaactggct tcagcagagc gcagatacca      120

aatactgtcc ttctagtgta gccgtagtta ggccaccact tcaagaactc tgtagcaccg      180

cctacatacc tcgctctgct gaagccagtt accagtggct gctgccagtg gcgataagtc      240

gtgtcttacc gggttggact caagagatag ttaccggata aggcgcagcg gtcgggctga      300

acggggggtt cgtgcacaca gcccagcttg gagcgaacga cctacaccga actgagatac      360

ctacagcgtg agctatgaga aagcgccacg cttcccgaag ggagaaaggc ggacaggtat      420

ccggtaagcg gcagggtcgg aacaggagag cgcacgaggg agcttccagg gggaaacgcc      480

tggtatcttt atagtcctgt cgggtttcgc cacctctgac ttgagcgtcg atttttgtga      540

tgctcgtcag gggggcggag cctatggaaa aacgccagca acgcaagcta gagtttaaac      600

ttgacagatg agacaataac cctgataaat gcttcaataa tattgaaaaa ggaaaagtat      660

gagtattcaa catttccgtg tcgcccttat tccctttttt gcggcatttt gccttcctgt      720

ttttgctcac ccagaaacgc tggtgaaagt aaaagatgca gaagatcact tgggtgcgcg      780

agtgggttac atcgaactgg atctcaacag cggtaagatc cttgagagtt ttcgccccga      840

agaacgtttc ccaatgatga gcacttttaa agttctgcta tgtggcgcgg tattatcccg      900

tattgatgcc gggcaagagc aactcggtcg ccgcatacac tattctcaga atgacttggt      960

tgaatactca ccagtcacag aaaagcatct tacggatggc atgacagtaa gagaattatg     1020

cagtgctgcc ataaccatga gtgataacac tgcggccaac ttacttctga caactatcgg     1080

aggaccgaag gagctaaccg cttttttgca caacatgggg gatcatgtaa ctcgccttga     1140

tcgttgggaa ccggagctga atgaagccat accaaacgac gagcgtgaca ccacgatgcc     1200

tgtagcaatg gcaacaacgt tgcgaaaact attaactggc gaactactta ctctagcttc     1260

ccggcaacaa ctaatagact ggatggaggc ggataaagtt gcaggaccac ttctgcgctc     1320

ggcacttccg gctggctggt ttattgctga taaatcagga gccggtgagc gtgggtcacg     1380

cggtatcatt gcagcactgg ggccggatgg taagccctcc cgtatcgtag ttatctacac     1440

tacggggagt caggcaacta tggatgaacg aaatagacag atcgctgaga taggtgcctc     1500

actgattaag cattggtaag gataaatttc tggtaaggag gacacgtatg gaagtgggca     1560

agttggggaa gccgtatccg ttgctgaatc tggcatatgt gggagtataa gacgcgcagc     1620

gtcgcatcag gcattttttt ctgcgccaat gcaaaaaggc catccgtcag gatggccttt     1680

cggcataact agggccgccg atatttgaaa atatggcata ttgaaaatgt cgccgatgtg     1740

agtttctgtg taactgatat cgccattttt ccaaaagtga tttttgggca tacgcgatat     1800

ctggcgatag cgcttatatc gtttacgggg gatggcgata gacgactttg gtgacttggg     1860

cgattctgtg tgtcgcaaat atcgcagttt cgatataggt gacagacgat atgaggctat     1920

atcgccgata gaggcgacat caagctggca catggccaat gcatatcgat ctatacattg     1980

aatcaatatt ggccattagc catattattc attggttata tagcataaat caatattggc     2040

tattggccat tgcatacgtt gtatccatat cataatatgt acatttatat tggctcatgt     2100

ccaacattac cgccatgttg acattgatta ttgactagtt attaatagta atcaattacg     2160

gggtcattag ttcatagccc atatatggag ttccgcgtta cataacttac ggtaaatggc     2220

ccgcctggct gaccgcccaa cgacccccgc ccattgacgt caataatgac gtatgttccc     2280

atagtaacgc caatagggac tttccattga cgtcaatggg tggagtattt acggtaaact     2340

gcccacttgg cagtacatca agtgtatcat atgccaagta cgccccctat tgacgtcaat     2400

gacggtaaat ggcccgcctg gcattatgcc cagtacatga ccttatggga ctttcctact     2460

tggcagtaca tctacgtatt agtcatcgct attaccatgg tgatgcggtt ttggcagtac     2520

atcaatgggc gtggatagcg gtttgactca cggggatttc caagtctcca ccccattgac     2580

gtcaatggga gtttgttttg gcaccaaaat caacgggact ttccaaaatg tcgtaacaac     2640

tccgccccat tgacgcaaat gggcggtagg cgtgtacggt gggaggtcta tataagcaga     2700

gctcgtttag tgaaccgtca gatcgcctgg agacgccatc cacgctgttt tgacctccat     2760

agaagacacc gggaccgatc cagcctccgc ggccgggaac ggtgcattgg aacgcggatt     2820

ccccgtgcca agagtgacgt aagtaccgcc tatagagtct ataggcccac ccccttggct     2880

tcttatgcat gctatactgt ttttggcttg gggtctatac accccccgnn ttcntcatgt     2940

tataggtgat ggtatagctt agcctatagg tgtgggttat tgaccattat tgaccactcc     3000

ccctattggt gacgatactt tccattacta atccataaca tggctctttg ccacaactct     3060

ctttattggc tatatgccaa tacactgtcc ttcagagact gacacggact ctgtattttt     3120

acaggatggg gtctcattta ttatttacaa attcacatat acaacaccac cgtccccagt     3180

gcccgcagtt tttattaaac ataacgtggg atctccacgc gaatctcggg tacgtgttcc     3240

ggacatgggc tcttctccgg tagcggcgga gcttctacat ccgagccctg ctcccatgcc     3300

tccagcgact catggtcgct cggcagctcc ttgctcctaa cagtggaggc cagacttagg     3360

cacagcacga tgcccaccac caccagtgtg ccgcacaagg ccgtggcggt agggtatgtg     3420

tctgaaaatg agctcgggga gcgggcttgc accgctgacg catttggaag acttaaggca     3480

gcggcagaag aagatgcagg cagctgagtt gttgtgttct gataagagtc agaggtaact     3540

cccgttgcgg tgctgttaac ggtggagggc agtgtagtct gagcagtact cgttgctgcc     3600

gcgcgcgcca ccagacataa tagctgacag actaacagac tgttcctttc catgggtctt     3660

ttctgcagtc accgtccttg acacgaagct gctagcgcca ccatgagcag cagtagttgg     3720

cttctcttga gtttggtggc agtgacagca gcccagagta ctatcgagga gcaggctaaa     3780

tactttctgg ataagtttaa cgccgaggcc gaagacttgt tctatcaatc ttctctcgct     3840

tcatggaatt acaatactaa catcactgag gagaacgtcc agaatatgaa caatgctggc     3900

gacaaatgga gcgccttctt gaaggagcag tctacccttg cacaaatgta tccactgcag     3960

gagatacaga accttacagt aaagttgcag ctccaggctc tccagcagaa cggatctagc     4020

gtgctttcag aggataaaag caaaaggctg aacaccatac ttaataccat gtccacaatt     4080

tactctactg gtaaagtatg taaccccgac aaccctcaag aatgcctcct tcttgagcca     4140

ggcctcaatg agatcatggc taatagtctg gactataatg aaagactgtg ggcatgggag     4200

tcctggagat ctgaagtagg gaagcaactg aggccccttt atgaagagta cgtcgtactt     4260

aagaatgaaa tggcccgcgc taaccactac gaggattacg gcgattactg gcgtggggac     4320

tatgaagtaa atggtgtaga tggatacgac tatagtcgtg ggcaattgat tgaggatgtg     4380

gagcacactt ttgaggagat aaaaccactc tatgagcatc ttcacgcata tgtgagagct     4440

aaactgatga acgcctaccc aagttacatc agtccaatcg gatgtctccc agctcacctc     4500

cttggcgaca tgtggggacg tttctggacc aatctgtatt ccctcacagt ccctttcggg     4560

caaaagccta atatagacgt gacagacgca atggttgatc aggcttggga tgctcaaagg     4620

atttttaagg aagctgagaa gttttttgtg tcagtcggtt tgccaaatat gacacaaggc     4680

ttctgggaaa atagcatgtt gactgatccc ggtaatgttc aaaaggctgt gtgtgcccct     4740

accgcttggg accttgggaa aggtgacttt cgaatcttga tgtgtaccaa ggtgacaatg     4800

gatgactttc ttacagccca tcatgaaatg ggtcacatcc agtatgatat ggcttatgca     4860

gctcaacctt tcctcttgag aaatggtgca aatgaaggtt ttcatgaagc tgtaggggaa     4920

ataatgtccc tgagtgctgc aaccccaaag catctcaaga gtatcggatt gttgagccca     4980

gattttcaag aagataacga gaccgaaatc aacttccttc tgaaacaagc cctcacaata     5040

gttggtactc ttccattcac atacatgctg gagaaatggc gttggatggt ttttaagggg     5100

gagataccta aagatcagtg gatgaaaaag tggtgggaga tgaagcgtga gatcgtaggg     5160

gtcgtggagc cagtgcctca tgatgagact tactgtgacc cagcatcact cttccacgtt     5220

agcaatgact attcatttat acgttattac actcgcactc tttaccagtt tcaatttcag     5280

gaggctctgt gtcaggctgc caagcatgag ggaccccttc acaagtgtga tattagtaac     5340

agtactgagg caggccaaaa actgttcaat atgttgaggc ttggcaaaag cgagccatgg     5400

actctcgcct tggaaaatgt tgtcggggct aaaaacatga atgtacgccc tctgcttaac     5460

tattttgagc ccctttttac atggctcaag gaccagaata agaactcctt tgtcggctgg     5520

tcaacagact ggtctcccta tgcagacaaa acacatactt gcccaccttg tcctgcacca     5580

gagctgctgg gaggtccaag cgtgttcctg tttccaccca agcccaaaga cacactgatg     5640

atttctcgaa ctccagaagt gacctgcgtg gtcgtggacg tgagccacga ggatcccgaa     5700

gtgaagttca actggtacgt ggatggcgtg gaggtccata atgctaagac taaaccccgg     5760

gaggaacagt acaacagcac ttatagggtc gtgtccgtgc tgaccgtcct gcatcaggat     5820

tggctgaacg ggaaggaata taagtgcaaa gtgtctaata aggcactgcc cgcccctatc     5880

gagaaaacaa ttagcaaggc taagggtcag cctagagaac cacaggtgta cactctgcct     5940

ccaagtcgcg acgagctgac caagaaccag gtgtcactga catgtctggt caaaggcttt     6000

tatccctcag atatcgcagt ggagtgggaa agcaatggac agcctgagaa caattacaag     6060

accacacccc ctgtgctgga cagtgatggc tcattctttc tgtattctaa gctgacagtg     6120

gacaaaagta ggtggcagca gggaaacgtg ttctcctgct ctgtcatgca cgaagcactg     6180

cacaatcatt atacccagaa gagtctgtca ctgagccctg gcaaatgagc gataccgatt     6240

ctagaactag atcataatca gccataccac atttgtagag gttttacttg ctttaaaaaa     6300

cctcccacac ctccccctga acctgaaaca taaaatgaat gcaattgttg ttgttaactt     6360

gtttattgca gcttataatg gttacaaata aagcaatagc atcacaaatt tcacaaataa     6420

agcatttttt tcactgcatt ctagttgtgg tttgtccaaa ctcatcaatg tatcttaagg     6480

ccgcaggtaa gccagcccag gcctcgccct ccagctcaag gcgggacagg tgccctagag     6540

tagcctgcat ccagggacag gccccagccg ggtgctgaca cgtccacctc catctcttcc     6600

tcaggtctgc ccgggtggca tccctgtgac ccctccccag tgcctctcct ggtcgtggaa     6660

ggtgctactc cagtgcccac cagccttgtc ctaataaaat taagttgcat cattttgttt     6720

gactaggtgt ccttgtataa tattatgggg tggaggcggg tggtatggag caaggggccc     6780

aagttaactt gtttattgca gcttataatg gttacaaata aagcaatagc atcacaaatt     6840

tcacaaataa agcatttttt tcactgcatt ctagttgtgg tttgtccaaa ctcatcaatg     6900

tatcttatca tgtctggatc cgcttcaggc accgggcttg cgggtcatgc accaggtgcg     6960

cggtccttcg ggcacctcga cgtcggcggt gacggtgaag ccgagccgct cgtagaaggg     7020

gaggttgcgg ggcgcggagg tctccaggaa ggcgggcacc ccggcgcgct cggccgcctc     7080

cactccgggg agcacgacgg cgctgcccag acccttgccc tggtggtcgg gcgagacgcc     7140

gacggtggcc aggaaccacg cgggctcctt gggccggtgc ggcgccagga ggccttccat     7200

ctgttgctgc gcggccagcc tggaaccgct caactcggcc atgcgcgggc cgatctcggc     7260

gaacaccgcc cccgcttcga cgctctccgg cgtggtccag accgccaccg cggcgccgtc     7320

gtccgcgacc cacaccttgc cgatgtcgag cccgacgcgc gtgaggaaga gttcttgcag     7380

ctcggtgacc cgctcgatgt ggcggtccgg gtcgacggtg tggcgcgtgg cggggtagtc     7440

ggcgaacgcg gcggcgaggg tgcgtacggc ccgggggacg tcgtcgcggg tggcgaggcg     7500

caccgtgggc ttgtactcgg tcatggtggc ctgcagagtc gctctgtgtt cgaggccaca     7560

cgcgtcacct taatatgcga agtggacctg ggaccgcgcc gccccgactg catctgcgtg     7620

ttttcgccaa tgacaagacg ctgggcgggg tttgtgtcat catagaacta aagacatgca     7680

aatatatttc ttccggggac accgccagca aacgcgagca acgggccacg gggatgaagc     7740

agctgcgcca ctccctgaag atccatcgtc tcctaacaag ttacatcact cctgcccttc     7800

ctcaccctca tctccatcac ctccttcatc tccgtcatct ccgtcatcac cctccgcggc     7860

agccccttcc accataggtg gaaaccaggg aggcaaatct actccatcgt caaagctgca     7920

cacagtcacc ctgatattgc aggtaggagc gggctttgtc ataacaaggt ccttaatcgc     7980

atccttcaaa acctcagcaa atatatgagt ttgtaaaaag accatgaaat aacagacaat     8040

ggactccctt agcgggccag gttgtgggcc gggtccaggg gccattccaa aggggagacg     8100

actcaatggt gtaagacgac attgtggaat agcaagggca gttcctcgcc ttaggttgta     8160

aagggaggtc ttactacctc catatacgaa cacaccggcg acccaagttc cttcgtcggt     8220

agtcctttct acgtgactcc tagccaggag agctcttaaa ccttctgcaa tgttctcaaa     8280

tttcgggttg gaacctcctt gaccacgatg ctttccaaac caccctcctt ttttgcgcct     8340

gcctccatca ccctgacccc cgctgcgcgg gggcacgtca ggctcaccat ctgggccgcc     8400

ttcttggtgg tattcaaaat aatcggcttc ccctacaggg tggaaaaatg gccttctacc     8460

tggagggggc ctgcgcggtg gagacccgga tgatgatgac tgactactgg gactcctggg     8520

cctcttttct ccacgtccac gacctctccc cctggctctt tcacgacttc cccccctggc     8580

tctttcacgt cctctacccc ggcggcctcc actacctcct cgaccccggc ctccactacc     8640

tcctcgaccc cggcctccac tgcctcctcg accccggcct ccacctcctg ctcctgcccc     8700

tcccgctcct gctcctgctc ctgttccacc gtgggtccct ttgcagccaa tgcaacttgg     8760

acgtttttgg ggtctccgga caccatctct atgtcttggc cctgatcctg agccgcccgg     8820

ggctcctggt cttccgcctc ctcgtcctcg tcctcttccc cgtcctcgtc catgtgccat     8880

gatggcggcc tgcagctgtg ttcgaggccg cgcgtgtcac cttaatatgc gaagtggacc     8940

tgggaccgcg ccgccccgac tgcatctgcg tgttcgagtt cgccaatgac aagacgctgg     9000

gcggggagat cccccttatt aaccctaaac gggtagcata tgcttcccgg gtagtagtat     9060

atactatcca gactaaccct aattcaatag catatgttac ccaacgggaa gcatatgcta     9120

tcgaattagg gttagtaaaa gggtcctaag gaacagcgat ctggatagca tatgctatcc     9180

taatctatat ctgggtagca tatgctatcc taatctatat ctgggtagca taggctatcc     9240

taatctatat ctgggtagca tatgctatcc taatctatat ctgggtagta tatgctatcc     9300

taatttatat ctgggtagca taggctatcc taatctatat ctgggtagca tatgctatcc     9360

taatctatat ctgggtagta tatgctatcc taatctgtat ccgggtagca tatgctatcc     9420

tcatgcatat acagtcagca tatgataccc agtagtagag tgggagtgct atcctttgca     9480

tatgccgcca cctcccaagg agatctgtcg acatcgatgg gcgcgggtgt acactccgcc     9540

catcccgccc ctaactccgc ccagttccgc ccattctccg cctcatggct gactaatttt     9600

ttttatttat gcagaggccg aggccgcctc ggcctctgag ctattccaga agtagtgagg     9660

aggctttttt ggaggcctag gcttttgcaa aaagctaatt c                         9701


<210>  232
<211>  38496
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  vector for IgA against T27Y H34A R273Q ACE2 mutant

<400>  232
tattattgat gatgttaatt aacatgcatg gatcctacgt ctcgaccgat gcccttgaga       60

gccttcaacc cagtcagctc cttccggtgg gcgcggggca tgactatcgt cgccgcactt      120

atgactgtct tctttatcat gcaactcgta ggacaggtgc cggcagcgct ctgggtcatt      180

ttcggcgagg accgctttcg ctggagcgcg acgatgatcg gcctgtcgct tgcggtattc      240

ggaatcttgc acgccctcgc tcaagccttc gtcactggtc ccgccaccaa acgtttcggc      300

gagaagcagg ccattatcgc cggcatggcg gccgacgcgc tgggctacgt cttgctggcg      360

ttcgcgacgc gaggctggat ggccttcccc attatgattc ttctcgcttc cggcggcatc      420

gggatgcccg cgttgcaggc catgctgtcc aggcaggtag atgacgacca tcagggacag      480

cttcaaggat cgctcgcggc tcttaccagc ctaacttcga tcattggacc gctgatcgtc      540

acggcgattt atgccgcctc ggcgagcaca tggaacgggt tggcatggat tgtaggcgcc      600

gccctatacc ttgtctgcct ccccgcgttg cgtcgcggtg catggagccg ggccacctcg      660

acctgaatgg aagccggcgg cacctcgcta acggattcac cactccaaga attggagcca      720

atcaattctt gcggagaact gtgaatgcgc aaaccaaccc ttggcagaac atatccatcg      780

cgtccgccat ctccagcagc cgcacgcggc gcatctcggg cagcgttggg tcctggccac      840

gggtgcgcat gatcgtgctc ctgtcgttga ggacccggct aggctggcgg ggttgcctta      900

ctggttagca gaatgaatca ccgatacgcg agcgaacgtg aagcgactgc tgctgcaaaa      960

cgtctgcgac ctgagcaaca acatgaatgg tcttcggttt ccgtgtttcg taaagtctgg     1020

aaacgcggaa gtcagcgccc tgcaccatta tgttccggat ctgcatcgca ggatgctgct     1080

ggctaccctg tggaacacct acatctgtat taacgaagcg ctggcattga ccctgagtga     1140

tttttctctg gtcccgccgc atccataccg ccagttgttt accctcacaa cgttccagta     1200

accgggcatg ttcatcatca gtaacccgta tcgtgagcat cctctctcgt ttcatcggta     1260

tcattacccc catgaacaga aatccccctt acacggaggc atcagtgacc aaacaggaaa     1320

aaaccgccct taacatggcc cgctttatca gaagccagac attaacgctt ctggagaaac     1380

tcaacgagct ggacgcggat gaacaggcag acatctgtga atcgcttcac gaccacgctg     1440

atgagcttta ccgcagctgc ctcgcgcgtt tcggtgatga cggtgaaaac ctctgacaca     1500

tgcagctccc ggagacggtc acagcttgtc tgtaagcgga tgccgggagc agacaagccc     1560

gtcagggcgc gtcagcgggt gttggcgggt gtcggggcgc agccatgacc cagtcacgta     1620

gcgatagcgg agtgtatact ggcttaacta tgcggcatca gagcagattg tactgagagt     1680

gcaccatatg cggtgtgaaa taccgcacag atgcgtaagg agaaaatacc gcatcaggcg     1740

ctcttccgct tcctcgctca ctgactcgct gcgctcggtc gttcggctgc ggcgagcggt     1800

atcagctcac tcaaaggcgg taatacggtt atccacagaa tcaggggata acgcaggaaa     1860

gaacatgtga gcaaaaggcc agcaaaaggc caggaaccgt aaaaaggccg cgttgctggc     1920

gtttttccat aggctccgcc cccctgacga gcatcacaaa aatcgacgct caagtcagag     1980

gtggcgaaac ccgacaggac tataaagata ccaggcgttt ccccctggaa gctccctcgt     2040

gcgctctcct gttccgaccc tgccgcttac cggatacctg tccgcctttc tcccttcggg     2100

aagcgtggcg ctttctcata gctcacgctg taggtatctc agttcggtgt aggtcgttcg     2160

ctccaagctg ggctgtgtgc acgaaccccc cgttcagccc gaccgctgcg ccttatccgg     2220

taactatcgt cttgagtcca acccggtaag acacgactta tcgccactgg cagcagccac     2280

tggtaacagg attagcagag cgaggtatgt aggcggtgct acagagttct tgaagtggtg     2340

gcctaactac ggctacacta gaaggacagt atttggtatc tgcgctctgc tgaagccagt     2400

taccttcgga aaaagagttg gtagctcttg atccggcaaa caaaccaccg ctggtagcgg     2460

tggttttttt gtttgcaagc agcagattac gcgcagaaaa aaaggatctc aagaagatcc     2520

tttgatcttt tctacggggt ctgacgctca gtggaacgaa aactcacgtt aagggatttt     2580

ggtcatgaga ttatcaaaaa ggatcttcac ctagatcctt ttaaattaaa aatgaagttt     2640

taaatcaatc taaagtatat atgagtaaac ttggtctgac agttaccaat gcttaatcag     2700

tgaggcacct atctcagcga tctgtctatt tcgttcatcc atagttgcct gactccccgt     2760

cgtgtagata actacgatac gggagggctt accatctggc cccagtgctg caatgatacc     2820

gcgagaccca cgctcaccgg ctccagattt atcagcaata aaccagccag ccggaagggc     2880

cgagcgcaga agtggtcctg caactttatc cgcctccatc cagtctatta attgttgccg     2940

ggaagctaga gtaagtagtt cgccagttaa tagtttgcgc aacgttgttg ccattgctgc     3000

agccatgaga ttatcaaaaa ggatcttcac ctagatcctt ttcacgtaga aagccagtcc     3060

gcagaaacgg tgctgacccc ggatgaatgt cagctactgg gctatctgga caagggaaaa     3120

cgcaagcgca aagagaaagc aggtagcttg cagtgggctt acatggcgat agctagactg     3180

ggcggtttta tggacagcaa gcgaaccgga attgccagct ggggcgccct ctggtaaggt     3240

tgggaagccc tgcaaagtaa actggatggc tttcttgccg ccaaggatct gatggcgcag     3300

gggatcaagc tctgatcaag agacaggatg aggatcgttt cgcatgattg aacaagatgg     3360

attgcacgca ggttctccgg ccgcttgggt ggagaggcta ttcggctatg actgggcaca     3420

acagacaatc ggctgctctg atgccgccgt gttccggctg tcagcgcagg ggcgcccggt     3480

tctttttgtc aagaccgacc tgtccggtgc cctgaatgaa ctgcaagacg aggcagcgcg     3540

gctatcgtgg ctggccacga cgggcgttcc ttgcgcagct gtgctcgacg ttgtcactga     3600

agcgggaagg gactggctgc tattgggcga agtgccgggg caggatctcc tgtcatctca     3660

ccttgctcct gccgagaaag tatccatcat ggctgatgca atgcggcggc tgcatacgct     3720

tgatccggct acctgcccat tcgaccacca agcgaaacat cgcatcgagc gagcacgtac     3780

tcggatggaa gccggtcttg tcgatcagga tgatctggac gaagagcatc aggggctcgc     3840

gccagccgaa ctgttcgcca ggctcaaggc gagcatgccc gacggcgagg atctcgtcgt     3900

gacccatggc gatgcctgct tgccgaatat catggtggaa aatggccgct tttctggatt     3960

catcgactgt ggccggctgg gtgtggcgga ccgctatcag gacatagcgt tggctacccg     4020

tgatattgct gaagagcttg gcggcgaatg ggctgaccgc ttcctcgtgc tttacggtat     4080

cgccgctccc gattcgcagc gcatcgcctt ctatcgcctt cttgacgagt tcttctgaat     4140

tttgttaaaa tttttgttaa atcagctcat tttttaacca ataggccgaa atcggcaaaa     4200

tcccttataa atcaaaagaa tagaccgaga tagggttgag tgttgttcca gtttggaaca     4260

agagtccact attaaagaac gtggactcca acgtcaaagg gcgaaaaacc gtctatcagg     4320

gcgatggccc actacgtgaa ccatcaccct aatcaagttt tttggggtcg aggtgccgta     4380

aagcactaaa tcggaaccct aaagggagcc cccgatttag agcttgacgg ggaaagccgg     4440

cgaacgtggc gagaaaggaa gggaagaaag cgaaaggagc gggcgctagg gcgctggcaa     4500

gtgtagcggt cacgctgcgc gtaaccacca cacccgccgc gcttaatgcg ccgctacagg     4560

gcgcgtccat tcgccattca ggatcgaatt aattcttaat taacatcatc aataatatac     4620

cttattttgg attgaagcca atatgataat gagggggtgg agtttgtgac gtggcgcggg     4680

gcgtgggaac ggggcgggtg acgtagtagt gtggcggaag tgtgatgttg caagtgtggc     4740

ggaacacatg taagcgacgg atgtggcaaa agtgacgttt ttggtgtgcg ccggtgtaca     4800

caggaagtga caattttcgc gcggttttag gcggatgttg tagtaaattt gggcgtaacc     4860

gagtaagatt tggccatttt cgcgggaaaa ctgaataaga ggaagtgaaa tctgaataat     4920

tttgtgttac tcatagcgcg taatactgta atagtaatca attacggggt cattagttca     4980

tagcccatat atggagttcc gcgttacata acttacggta aatggcccgc ctggctgacc     5040

gcccaacgac ccccgcccat tgacgtcaat aatgacgtat gttcccatag taacgccaat     5100

agggactttc cattgacgtc aatgggtgga gtatttacgg taaactgccc acttggcagt     5160

acatcaagtg tatcatatgc caagtacgcc ccctattgac gtcaatgacg gtaaatggcc     5220

cgcctggcat tatgcccagt acatgacctt atgggacttt cctacttggc agtacatcta     5280

cgtattagtc atcgctatta ccatggtgat gcggttttgg cagtacatca atgggcgtgg     5340

atagcggttt gactcacggg gatttccaag tctccacccc attgacgtca atgggagttt     5400

gttttggcac caaaatcaac gggactttcc aaaatgtcgt aacaactccg ccccattgac     5460

gcaaatgggc ggtaggcgtg tacggtggga ggtctatata agcagagctg gtttagtgaa     5520

ccgtcagatc cgctagagat ctggtaccgt cgacgcggcc gctcgagcct aagcttatga     5580

gcagcagtag ttggcttctc ttgagtttgg tggcagtgac agcagcccag agtactatcg     5640

aggagcaggc taaatacttt ctggataagt ttaacgccga ggccgaagac ttgttctatc     5700

aatcttctct cgcttcatgg aattacaata ctaacatcac tgaggagaac gtccagaata     5760

tgaacaatgc tggcgacaaa tggagcgcct tcttgaagga gcagtctacc cttgcacaaa     5820

tgtatccact gcaggagata cagaacctta cagtaaagtt gcagctccag gctctccagc     5880

agaacggatc tagcgtgctt tcagaggata aaagcaaaag gctgaacacc atacttaata     5940

ccatgtccac aatttactct actggtaaag tatgtaaccc cgacaaccct caagaatgcc     6000

tccttcttga gccaggcctc aatgagatca tggctaatag tctggactat aatgaaagac     6060

tgtgggcatg ggagtcctgg agatctgaag tagggaagca actgaggccc ctttatgaag     6120

agtacgtcgt acttaagaat gaaatggccc gcgctaacca ctacgaggat tacggcgatt     6180

actggcgtgg ggactatgaa gtaaatggtg tagatggata cgactatagt cgtgggcaat     6240

tgattgagga tgtggagcac acttttgagg agataaaacc actctatgag catcttcacg     6300

catatgtgag agctaaactg atgaacgcct acccaagtta catcagtcca atcggatgtc     6360

tcccagctca cctccttggc gacatgtggg gacagttctg gaccaatctg tattccctca     6420

cagtcccttt cgggcaaaag cctaatatag acgtgacaga cgcaatggtt gatcaggctt     6480

gggatgctca aaggattttt aaggaagctg agaagttttt tgtgtcagtc ggtttgccaa     6540

atatgacaca aggcttctgg gaaaatagca tgttgactga tcccggtaat gttcaaaagg     6600

ctgtgtgtca ccctaccgct tgggaccttg ggaaaggtga ctttcgaatc ttgatgtgta     6660

ccaaggtgac aatggatgac tttcttacag cccatcatga aatgggtcac atccagtatg     6720

atatggctta tgcagctcaa cctttcctct tgagaaatgg tgcaaatgaa ggttttcatg     6780

aagctgtagg ggaaataatg tccctgagtg ctgcaacccc aaagcatctc aagagtatcg     6840

gattgttgag cccagatttt caagaagata acgagaccga aatcaacttc cttctgaaac     6900

aagccctcac aatagttggt actcttccat tcacatacat gctggagaaa tggcgttgga     6960

tggtttttaa gggggagata cctaaagatc agtggatgaa aaagtggtgg gagatgaagc     7020

gtgagatcgt aggggtcgtg gagccagtgc ctcatgatga gacttactgt gacccagcat     7080

cactcttcca cgttagcaat gactattcat ttatacgtta ttacactcgc actctttacc     7140

agtttcaatt tcaggaggct ctgtgtcagg ctgccaagca tgagggaccc cttcacaagt     7200

gtgatattag taacagtact gaggcaggcc aaaaactgtt caatatgttg aggcttggca     7260

aaagcgagcc atggactctc gccttggaaa atgttgtcgg ggctaaaaac atgaatgtac     7320

gccctctgct taactatttt gagccccttt ttacatggct caaggaccag aataagaact     7380

cctttgtcgg ctggtcaaca gactggtctc cctatgcaga ccctagtact cctcctactc     7440

cttctccatc aaccccacca actccatccc ctagctgctg tcacccaagg ctgtctctgc     7500

accgacctgc actcgaagac cttctgttgg gctctgaagc taacctgacc tgtactctta     7560

ctggcttgcg cgatgctagc ggcgtgactt tcacctggac acctagtagc ggtaaaagtg     7620

ctgtacaagg acctcctgaa cgcgacctgt gtggttgcta ctctgtgtct tctgtacttc     7680

ccggctgtgc cgagccctgg aatcacggga aaacctttac ctgcaccgcc gcttaccctg     7740

agtcaaaaac tcccctcact gccacattga gtaagtcagg gaatacattc aggccagagg     7800

ttcatttgtt gcctcctcca tctgaagaac ttgctttgaa cgagctggtc actctgacct     7860

gcttggctag gggtttctcc cccaaagatg tacttgtacg gtggttgcag ggcagccaag     7920

agttgccccg cgaaaagtat ttgacctggg cctcaagaca agaacccagc caggggacta     7980

ccacatttgc cgtgaccagt attctgcgtg tagccgctga agattggaag aaaggggata     8040

cattttcttg catggtaggg catgaggccc ttcccctcgc tttcactcag aagacaatag     8100

acagactcgc cggaaagcct actcacgtga atgttagcgt agtcatggct gaggttgacg     8160

gaacttgcta ctgagatatc cgatccaccg gatctagata actgatcata atcagccata     8220

ccacatttgt agaggtttta cttgctttaa aaaacctccc acacctcccc ctgaacctga     8280

aacataaaat gaatgcaatt gttgttgtta acttgtttat tgcagcttat aatggttaca     8340

aataaagcaa tagcatcaca aatttcacaa ataaagcatt tttttcactg cattctagtt     8400

gtggtttgtc caaactcatc aatgtatctt aggtttagtg aaccgtcaga tccgctagcg     8460

ttacataact tacggtaaat ggcccgcctg gctgaccgcc caacgacccc cgcccattga     8520

cgtcaataat gacgtatgtt cccatagtaa cgccaatagg gactttccat tgacgtcaat     8580

gggtggagta tttacggtaa actgcccact tggcagtaca tcaagtgtat catatgccaa     8640

gtacgccccc tattgacgtc aatgacggta aatggcccgc ctggcattat gcccagtaca     8700

tgaccttatg ggactttcct acttggcagt acatctacgt attagtcatc gctattacca     8760

tggtgatgcg gttttggcag tacatcaatg ggcgtggata gcggtttgac tcacggggat     8820

ttccaagtct ccaccccatt gacgtcaatg ggagtttgtt ttggcaccaa aatcaacggg     8880

actttccaaa atgtcgtaac aactccgccc cattgacgca aatgggcggt aggcgtgtac     8940

ggtgggaggt ctatataagc agagctggtt tagtgaaccg tcagatccgc tagagatctg     9000

gtaccgtcga cgcggccgct cgagcctaag cttatgaaga accatctgct tttctgggga     9060

gtacttgccg ttttcataaa agccgtacat gttaaagcac aagaggacga acgcattgtg     9120

ttggttgata ataaatgcaa atgtgctcgg ataacatctc ggatcattcg tagctcagag     9180

gaccccaatg aggatatagt agagcgaaac atcagaatta tagtacccct gaacaacaga     9240

gagaacataa gtgatcccac aagtccattg cggacacgct ttgtttacca tttgtctgat     9300

ctgtgtaaaa aatgtgatcc aacagaggtg gaactcgaca atcagatcgt caccgccacc     9360

cagtctaaca tctgcgatga agattcagct acagagacat gctacacata cgaccggaac     9420

aagtgctata ctgccgttgt gccactcgtt tacggtggag aaacaaagat ggttgaaact     9480

gcacttacac cagatgcctg ctatccagat tgagatatcc gatccaccgg atctagataa     9540

ctgatcataa tcagccatac cacatttgta gaggttttac ttgctttaaa aaacctccca     9600

cacctccccc tgaacctgaa acataaaatg aatgcaattg ttgttgttaa cttgtttatt     9660

gcagcttata atggttacaa ataaagcaat agcatcacaa atttcacaaa taaagcattt     9720

ttttcactgc attctagttg tggtttgtcc aaactcatca atgtatctta acgcggatct     9780

gggcgtggtt aagggtggga aagaatatat aaggtggggg tcttatgtag ttttgtatct     9840

gttttgcagc agccgccgcc gccatgagca ccaactcgtt tgatggaagc attgtgagct     9900

catatttgac aacgcgcatg cccccatggg ccggggtgcg tcagaatgtg atgggctcca     9960

gcattgatgg tcgccccgtc ctgcccgcaa actctactac cttgacctac gagaccgtgt    10020

ctggaacgcc gttggagact gcagcctccg ccgccgcttc agccgctgca gccaccgccc    10080

gcgggattgt gactgacttt gctttcctga gcccgcttgc aagcagtgca gcttcccgtt    10140

catccgcccg cgatgacaag ttgacggctc ttttggcaca attggattct ttgacccggg    10200

aacttaatgt cgtttctcag cagctgttgg atctgcgcca gcaggtttct gccctgaagg    10260

cttcctcccc tcccaatgcg gtttaaaaca taaataaaaa accagactct gtttggattt    10320

ggatcaagca agtgtcttgc tgtctttatt taggggtttt gcgcgcgcgg taggcccggg    10380

accagcggtc tcggtcgttg agggtcctgt gtattttttc caggacgtgg taaaggtgac    10440

tctggatgtt cagatacatg ggcataagcc cgtctctggg gtggaggtag caccactgca    10500

gagcttcatg ctgcggggtg gtgttgtaga tgatccagtc gtagcaggag cgctgggcgt    10560

ggtgcctaaa aatgtctttc agtagcaagc tgattgccag gggcaggccc ttggtgtaag    10620

tgtttacaaa gcggttaagc tgggatgggt gcatacgtgg ggatatgaga tgcatcttgg    10680

actgtatttt taggttggct atgttcccag ccatatccct ccggggattc atgttgtgca    10740

gaaccaccag cacagtgtat ccggtgcact tgggaaattt gtcatgtagc ttagaaggaa    10800

atgcgtggaa gaacttggag acgcccttgt gacctccaag attttccatg cattcgtcca    10860

taatgatggc aatgggccca cgggcggcgg cctgggcgaa gatatttctg ggatcactaa    10920

cgtcatagtt gtgttccagg atgagatcgt cataggccat ttttacaaag cgcgggcgga    10980

gggtgccaga ctgcggtata atggttccat ccggcccagg ggcgtagtta ccctcacaga    11040

tttgcatttc ccacgctttg agttcagatg gggggatcat gtctacctgc ggggcgatga    11100

agaaaacggt ttccggggta ggggagatca gctgggaaga aagcaggttc ctgagcagct    11160

gcgacttacc gcagccggtg ggcccgtaaa tcacacctat taccggctgc aactggtagt    11220

taagagagct gcagctgccg tcatccctga gcaggggggc cacttcgtta agcatgtccc    11280

tgactcgcat gttttccctg accaaatccg ccagaaggcg ctcgccgccc agcgatagca    11340

gttcttgcaa ggaagcaaag tttttcaacg gtttgagacc gtccgccgta ggcatgcttt    11400

tgagcgtttg accaagcagt tccaggcggt cccacagctc ggtcacctgc tctacggcat    11460

ctcgatccag catatctcct cgtttcgcgg gttggggcgg ctttcgctgt acggcagtag    11520

tcggtgctcg tccagacggg ccagggtcat gtctttccac gggcgcaggg tcctcgtcag    11580

cgtagtctgg gtcacggtga aggggtgcgc tccgggctgc gcgctggcca gggtgcgctt    11640

gaggctggtc ctgctggtgc tgaagcgctg ccggtcttcg ccctgcgcgt cggccaggta    11700

gcatttgacc atggtgtcat agtccagccc ctccgcggcg tggcccttgg cgcgcagctt    11760

gcccttggag gaggcgccgc acgaggggca gtgcagactt ttgagggcgt agagcttggg    11820

cgcgagaaat accgattccg gggagtaggc atccgcgccg caggccccgc agacggtctc    11880

gcattccacg agccaggtga gctctggccg ttcggggtca aaaaccaggt ttcccccatg    11940

ctttttgatg cgtttcttac ctctggtttc catgagccgg tgtccacgct cggtgacgaa    12000

aaggctgtcc gtgtccccgt atacagactt gagaggcctg tcctcgagcg gtgttccgcg    12060

gtcctcctcg tatagaaact cggaccactc tgagacaaag gctcgcgtcc aggccagcac    12120

gaaggaggct aagtgggagg ggtagcggtc gttgtccact agggggtcca ctcgctccag    12180

ggtgtgaaga cacatgtcgc cctcttcggc atcaaggaag gtgattggtt tgtaggtgta    12240

ggccacgtga ccgggtgttc ctgaaggggg gctataaaag ggggtggggg cgcgttcgtc    12300

ctcactctct tccgcatcgc tgtctgcgag ggccagctgt tggggtgagt actccctctg    12360

aaaagcgggc atgacttctg cgctaagatt gtcagtttcc aaaaacgagg aggatttgat    12420

attcacctgg cccgcggtga tgcctttgag ggtggccgca tccatctggt cagaaaagac    12480

aatctttttg ttgtcaagct tggtggcaaa cgacccgtag agggcgttgg acagcaactt    12540

ggcgatggag cgcagggttt ggtttttgtc gcgatcggcg cgctccttgg ccgcgatgtt    12600

tagctgcacg tattcgcgcg caacgcaccg ccattcggga aagacggtgg tgcgctcgtc    12660

gggcaccagg tgcacgcgcc aaccgcggtt gtgcagggtg acaaggtcaa cgctggtggc    12720

tacctctccg cgtaggcgct cgttggtcca gcagaggcgg ccgcccttgc gcgagcagaa    12780

tggcggtagg gggtctagct gcgtctcgtc cggggggtct gcgtccacgg taaagacccc    12840

gggcagcagg cgcgcgtcga agtagtctat cttgcatcct tgcaagtcta gcgcctgctg    12900

ccatgcgcgg gcggcaagcg cgcgctcgta tgggttgagt gggggacccc atggcatggg    12960

gtgggtgagc gcggaggcgt acatgccgca aatgtcgtaa acgtagaggg gctctctgag    13020

tattccaaga tatgtagggt agcatcttcc accgcggatg ctggcgcgca cgtaatcgta    13080

tagttcgtgc gagggagcga ggaggtcggg accgaggttg ctacgggcgg gctgctctgc    13140

tcggaagact atctgcctga agatggcatg tgagttggat gatatggttg gacgctggaa    13200

gacgttgaag ctggcgtctg tgagacctac cgcgtcacgc acgaaggagg cgtaggagtc    13260

gcgcagcttg ttgaccagct cggcggtgac ctgcacgtct agggcgcagt agtccagggt    13320

ttccttgatg atgtcatact tatcctgtcc cttttttttc cacagctcgc ggttgaggac    13380

aaactcttcg cggtctttcc agtactcttg gatcggaaac ccgtcggcct ccgaacggta    13440

agagcctagc atgtagaact ggttgacggc ctggtaggcg cagcatccct tttctacggg    13500

tagcgcgtat gcctgcgcgg ccttccggca tgaccagcat gaagggcacg agctgcttcc    13560

caaaggcccc catccaagta taggtctcta catcgtaggt gacaaagaga cgctcggtgc    13620

gaggatgcga gccgatcggg aagaactgga tctcccgcca ccaattggag gagtggctat    13680

tgatgtggtg aaagtagaag tccctgcgac gggccgaaca ctcgtgctgg cttttgtaaa    13740

aacgtgcgca gtactggcag cggtgcacgg gctgtacatc ctgcacgagg ttgacctgac    13800

gaccgcgcac aaggaagcag agtgggaatt tgagcccctc gcctggcggg tttggctggt    13860

ggtcttctac ttcggctgct tgtccttgac cgtctggctg ctcgagggga gttacggtgg    13920

atcggaccac cacgccgcgc gagcccaaag tccagatgtc cgcgcgcggc ggtcggagct    13980

tgatgacaac atcgcgcaga tgggagctgt ccatggtctg gagctcccgc ggcgtcaggt    14040

caggcgggag ctcctgcagg tttacctcgc atagacgggt cagggcgcgg gctagatcca    14100

ggtgatacct aatttccagg ggctggttgg tggcggcgtc gatggcttgc aagaggccgc    14160

atccccgcgg cgcgactacg gtaccgcgcg gcgggcggtg ggccgcgggg gtgtccttgg    14220

atgatgcatc taaaagcggt gacgcgggcg agcccccgga ggtagggggg gctccggacc    14280

cgccgggaga gggggcaggg gcacgtcggc gccgcgcgcg ggcaggagct ggtgctgcgc    14340

gcgtaggttg ctggcgaacg cgacgacgcg gcggttgatc tcctgaatct ggcgcctctg    14400

cgtgaagacg acgggcccgg tgagcttgaa cctgaaagag agttcgacag aatcaatttc    14460

ggtgtcgttg acggcggcct ggcgcaaaat ctcctgcacg tctcctgagt tgtcttgata    14520

ggcgatctcg gccatgaact gctcgatctc ttcctcctgg agatctccgc gtccggctcg    14580

ctccacggtg gcggcgaggt cgttggaaat gcgggccatg agctgcgaga aggcgttgag    14640

gcctccctcg ttccagacgc ggctgtagac cacgccccct tcggcatcgc gggcgcgcat    14700

gaccacctgc gcgagattga gctccacgtg ccgggcgaag acggcgtagt ttcgcaggcg    14760

ctgaaagagg tagttgaggg tggtggcggt gtgttctgcc acgaagaagt acataaccca    14820

gcgtcgcaac gtggattcgt tgataattgt tgtgtaggta ctccgccgcc gagggacctg    14880

agcgagtccg catcgaccgg atcggaaaac ctctcgagaa aggcgtctaa ccagtcacag    14940

tcgcaaggta ggctgagcac cgtggcgggc ggcagcgggc ggcggtcggg gttgtttctg    15000

gcggaggtgc tgctgatgat gtaattaaag taggcggtct tgagacggcg gatggtcgac    15060

agaagcacca tgtccttggg tccggcctgc tgaatgcgca ggcggtcggc catgccccag    15120

gcttcgtttt gacatcggcg caggtctttg tagtagtctt gcatgagcct ttctaccggc    15180

acttcttctt ctccttcctc ttgtcctgca tctcttgcat ctatcgctgc ggcggcggcg    15240

gagtttggcc gtaggtggcg ccctcttcct cccatgcgtg tgaccccgaa gcccctcatc    15300

ggctgaagca gggctaggtc ggcgacaacg cgctcggcta atatggcctg ctgcacctgc    15360

gtgagggtag actggaagtc atccatgtcc acaaagcggt ggtatgcgcc cgtgttgatg    15420

gtgtaagtgc agttggccat aacggaccag ttaacggtct ggtgacccgg ctgcgagagc    15480

tcggtgtacc tgagacgcga gtaagccctc gagtcaaata cgtagtcgtt gcaagtccgc    15540

accaggtact ggtatcccac caaaaagtgc ggcggcggct ggcggtagag gggccagcgt    15600

agggtggccg gggctccggg ggcgagatct tccaacataa ggcgatgata tccgtagatg    15660

tacctggaca tccaggtgat gccggcggcg gtggtggagg cgcgcggaaa gtcgcggacg    15720

cggttccaga tgttgcgcag cggcaaaaag tgctccatgg tcgggacgct ctggccggtc    15780

aggcgcgcgc aatcgttgac gctctagcgt gcaaaaggag agcctgtaag cgggcactct    15840

tccgtggtct ggtggataaa ttcgcaaggg tatcatggcg gacgaccggg gttcgagccc    15900

cgtatccggc cgtccgccgt gatccatgcg gttaccgccc gcgtgtcgaa cccaggtgtg    15960

cgacgtcaga caacggggga gtgctccttt tggcttcctt ccaggcgcgg cggctgctgc    16020

gctagctttt ttggccactg gccgcgcgca gcgtaagcgg ttaggctgga aagcgaaagc    16080

attaagtggc tcgctccctg tagccggagg gttattttcc aagggttgag tcgcgggacc    16140

cccggttcga gtctcggacc ggccggactg cggcgaacgg gggtttgcct ccccgtcatg    16200

caagaccccg cttgcaaatt cctccggaaa cagggacgag cccctttttt gcttttccca    16260

gatgcatccg gtgctgcggc agatgcgccc ccctcctcag cagcggcaag agcaagagca    16320

gcggcagaca tgcagggcac cctcccctcc tcctaccgcg tcaggagggg cgacatccgc    16380

ggttgacgcg gcagcagatg gtgattacga acccccgcgg cgccgggccc ggcactacct    16440

ggacttggag gagggcgagg gcctggcgcg gctaggagcg ccctctcctg agcggcaccc    16500

aagggtgcag ctgaagcgtg atacgcgtga ggcgtacgtg ccgcggcaga acctgtttcg    16560

cgaccgcgag ggagaggagc ccgaggagat gcgggatcga aagttccacg cagggcgcga    16620

gctgcggcat ggcctgaatc gcgagcggtt gctgcgcgag gaggactttg agcccgacgc    16680

gcgaaccggg attagtcccg cgcgcgcaca cgtggcggcc gccgacctgg taaccgcata    16740

cgagcagacg gtgaaccagg agattaactt tcaaaaaagc tttaacaacc acgtgcgtac    16800

gcttgtggcg cgcgaggagg tggctatagg actgatgcat ctgtgggact ttgtaagcgc    16860

gctggagcaa aacccaaata gcaagccgct catggcgcag ctgttcctta tagtgcagca    16920

cagcagggac aacgaggcat tcagggatgc gctgctaaac atagtagagc ccgagggccg    16980

ctggctgctc gatttgataa acatcctgca gagcatagtg gtgcaggagc gcagcttgag    17040

cctggctgac aaggtggccg ccatcaacta ttccatgctt agcctgggca agttttacgc    17100

ccgcaagata taccataccc cttacgttcc catagacaag gaggtaaaga tcgaggggtt    17160

ctacatgcgc atggcgctga aggtgcttac cttgagcgac gacctgggcg tttatcgcaa    17220

cgagcgcatc cacaaggccg tgagcgtgag ccggcggcgc gagctcagcg accgcgagct    17280

gatgcacagc ctgcaaaggg ccctggctgg cacgggcagc ggcgatagag aggccgagtc    17340

ctactttgac gcgggcgctg acctgcgctg ggccccaagc cgacgcgccc tggaggcagc    17400

tggggccgga cctgggctgg cggtggcacc cgcgcgcgct ggcaacgtcg gcggcgtgga    17460

ggaatatgac gaggacgatg agtacgagcc agaggacggc gagtactaag cggtgatgtt    17520

tctgatcaga tgatgcaaga cgcaacggac ccggcggtgc gggcggcgct gcagagccag    17580

ccgtccggcc ttaactccac ggacgactgg cgccaggtca tggaccgcat catgtcgctg    17640

actgcgcgca atcctgacgc gttccggcag cagccgcagg ccaaccggct ctccgcaatt    17700

ctggaagcgg tggtcccggc gcgcgcaaac cccacgcacg agaaggtgct ggcgatcgta    17760

aacgcgctgg ccgaaaacag ggccatccgg cccgacgagg ccggcctggt ctacgacgcg    17820

ctgcttcagc gcgtggctcg ttacaacagc ggcaacgtgc agaccaacct ggaccggctg    17880

gtgggggatg tgcgcgaggc cgtggcgcag cgtgagcgcg cgcagcagca gggcaacctg    17940

ggctccatgg ttgcactaaa cgccttcctg agtacacagc ccgccaacgt gccgcgggga    18000

caggaggact acaccaactt tgtgagcgca ctgcggctaa tggtgactga gacaccgcaa    18060

agtgaggtgt accagtctgg gccagactat tttttccaga ccagtagaca aggcctgcag    18120

accgtaaacc tgagccaggc tttcaaaaac ttgcaggggc tgtggggggt gcgggctccc    18180

acaggcgacc gcgcgaccgt gtctagcttg ctgacgccca actcgcgcct gttgctgctg    18240

ctaatagcgc ccttcacgga cagtggcagc gtgtcccggg acacatacct aggtcacttg    18300

ctgacactgt accgcgaggc cataggtcag gcgcatgtgg acgagcatac tttccaggag    18360

attacaagtg tcagccgcgc gctggggcag gaggacacgg gcagcctgga ggcaacccta    18420

aactacctgc tgaccaaccg gcggcagaag atcccctcgt tgcacagttt aaacagcgag    18480

gaggagcgca ttttgcgcta cgtgcagcag agcgtgagcc ttaacctgat gcgcgacggg    18540

gtaacgccca gcgtggcgct ggacatgacc gcgcgcaaca tggaaccggg catgtatgcc    18600

tcaaaccggc cgtttatcaa ccgcctaatg gactacttgc atcgcgcggc cgccgtgaac    18660

cccgagtatt tcaccaatgc catcttgaac ccgcactggc taccgccccc tggtttctac    18720

accgggggat tcgaggtgcc cgagggtaac gatggattcc tctgggacga catagacgac    18780

agcgtgtttt ccccgcaacc gcagaccctg ctagagttgc aacagcgcga gcaggcagag    18840

gcggcgctgc gaaaggaaag cttccgcagg ccaagcagct tgtccgatct aggcgctgcg    18900

gccccgcggt cagatgctag tagcccattt ccaagcttga tagggtctct taccagcact    18960

cgcaccaccc gcccgcgcct gctgggcgag gaggagtacc taaacaactc gctgctgcag    19020

ccgcagcgcg aaaaaaacct gcctccggca tttcccaaca acgggataga gagcctagtg    19080

gacaagatga gtagatggaa gacgtacgcg caggagcaca gggacgtgcc aggcccgcgc    19140

ccgcccaccc gtcgtcaaag gcacgaccgt cagcggggtc tggtgtggga ggacgatgac    19200

tcggcagacg acagcagcgt cctggatttg ggagggagtg gcaacccgtt tgcgcacctt    19260

cgccccaggc tggggagaat gttttaaaaa aaaaaaagca tgatgcaaaa taaaaaactc    19320

accaaggcca tggcaccgag cgttggtttt cttgtattcc ccttagtatg cggcgcgcgg    19380

cgatgtatga ggaaggtcct cctccctcct acgagagtgt ggtgagcgcg gcgccagtgg    19440

cggcggcgct gggttctccc ttcgatgctc ccctggaccc gccgtttgtg cctccgcggt    19500

acctgcggcc taccgggggg agaaacagca tccgttactc tgagttggca cccctattcg    19560

acaccacccg tgtgtacctg gtggacaaca agtcaacgga tgtggcatcc ctgaactacc    19620

agaacgacca cagcaacttt ctgaccacgg tcattcaaaa caatgactac agcccggggg    19680

aggcaagcac acagaccatc aatcttgacg accggtcgca ctggggcggc gacctgaaaa    19740

ccatcctgca taccaacatg ccaaatgtga acgagttcat gtttaccaat aagtttaagg    19800

cgcgggtgat ggtgtcgcgc ttgcctacta aggacaatca ggtggagctg aaatacgagt    19860

gggtggagtt cacgctgccc gagggcaact actccgagac catgaccata gaccttatga    19920

acaacgcgat cgtggagcac tacttgaaag tgggcagaca gaacggggtt ctggaaagcg    19980

acatcggggt aaagtttgac acccgcaact tcagactggg gtttgacccc gtcactggtc    20040

ttgtcatgcc tggggtatat acaaacgaag ccttccatcc agacatcatt ttgctgccag    20100

gatgcggggt ggacttcacc cacagccgcc tgagcaactt gttgggcatc cgcaagcggc    20160

aacccttcca ggagggcttt aggatcacct acgatgatct ggagggtggt aacattcccg    20220

cactgttgga tgtggacgcc taccaggcga gcttgaaaga tgacaccgaa cagggcgggg    20280

gtggcgcagg cggcagcaac agcagtggca gcggcgcgga agagaactcc aacgcggcag    20340

ccgcggcaat gcagccggtg gaggacatga acgatcatgc cattcgcggc gacacctttg    20400

ccacacgggc tgaggagaag cgcgctgagg ccgaagcagc ggccgaagct gccgcccccg    20460

ctgcgcaacc cgaggtcgag aagcctcaga agaaaccggt gatcaaaccc ctgacagagg    20520

acagcaagaa acgcagttac aacctaataa gcaatgacag caccttcacc cagtaccgca    20580

gctggtacct tgcatacaac tacggcgacc ctcagaccgg aatccgctca tggaccctgc    20640

tttgcactcc tgacgtaacc tgcggctcgg agcaggtcta ctggtcgttg ccagacatga    20700

tgcaagaccc cgtgaccttc cgctccacgc gccagatcag caactttccg gtggtgggcg    20760

ccgagctgtt gcccgtgcac tccaagagct tctacaacga ccaggccgtc tactcccaac    20820

tcatccgcca gtttacctct ctgacccacg tgttcaatcg ctttcccgag aaccagattt    20880

tggcgcgccc gccagccccc accatcacca ccgtcagtga aaacgttcct gctctcacag    20940

atcacgggac gctaccgctg cgcaacagca tcggaggagt ccagcgagtg accattactg    21000

acgccagacg ccgcacctgc ccctacgttt acaaggccct gggcatagtc tcgccgcgcg    21060

tcctatcgag ccgcactttt tgagcaagca tgtccatcct tatatcgccc agcaataaca    21120

caggctgggg cctgcgcttc ccaagcaaga tgtttggcgg ggccaagaag cgctccgacc    21180

aacacccagt gcgcgtgcgc gggcactacc gcgcgccctg gggcgcgcac aaacgcggcc    21240

gcactgggcg caccaccgtc gatgacgcca tcgacgcggt ggtggaggag gcgcgcaact    21300

acacgcccac gccgccacca gtgtccacag tggacgcggc cattcagacc gtggtgcgcg    21360

gagcccggcg ctatgctaaa atgaagagac ggcggaggcg cgtagcacgt cgccaccgcc    21420

gccgacccgg cactgccgcc caacgcgcgg cggcggccct gcttaaccgc gcacgtcgca    21480

ccggccgacg ggcggccatg cgggccgctc gaaggctggc cgcgggtatt gtcactgtgc    21540

cccccaggtc caggcgacga gcggccgccg cagcagccgc ggccattagt gctatgactc    21600

agggtcgcag gggcaacgtg tattgggtgc gcgactcggt tagcggcctg cgcgtgcccg    21660

tgcgcacccg ccccccgcgc aactagattg caagaaaaaa ctacttagac tcgtactgtt    21720

gtatgtatcc agcggcggcg gcgcgcaacg aagctatgtc caagcgcaaa atcaaagaag    21780

agatgctcca ggtcatcgcg ccggagatct atggcccccc gaagaaggaa gagcaggatt    21840

acaagccccg aaagctaaag cgggtcaaaa agaaaaagaa agatgatgat gatgaacttg    21900

acgacgaggt ggaactgctg cacgctaccg cgcccaggcg acgggtacag tggaaaggtc    21960

gacgcgtaaa acgtgttttg cgacccggca ccaccgtagt ctttacgccc ggtgagcgct    22020

ccacccgcac ctacaagcgc gtgtatgatg aggtgtacgg cgacgaggac ctgcttgagc    22080

aggccaacga gcgcctcggg gagtttgcct acggaaagcg gcataaggac atgctggcgt    22140

tgccgctgga cgagggcaac ccaacaccta gcctaaagcc cgtaacactg cagcaggtgc    22200

tgcccgcgct tgcaccgtcc gaagaaaagc gcggcctaaa gcgcgagtct ggtgacttgg    22260

cacccaccgt gcagctgatg gtacccaagc gccagcgact ggaagatgtc ttggaaaaaa    22320

tgaccgtgga acctgggctg gagcccgagg tccgcgtgcg gccaatcaag caggtggcgc    22380

cgggactggg cgtgcagacc gtggacgttc agatacccac taccagtagc accagtattg    22440

ccaccgccac agagggcatg gagacacaaa cgtccccggt tgcctcagcg gtggcggatg    22500

ccgcggtgca ggcggtcgct gcggccgcgt ccaagacctc tacggaggtg caaacggacc    22560

cgtggatgtt tcgcgtttca gccccccggc gcccgcgccg ttcgaggaag tacggcgccg    22620

ccagcgcgct actgcccgaa tatgccctac atccttccat tgcgcctacc cccggctatc    22680

gtggctacac ctaccgcccc agaagacgag caactacccg acgccgaacc accactggaa    22740

cccgccgccg ccgtcgccgt cgccagcccg tgctggcccc gatttccgtg cgcagggtgg    22800

ctcgcgaagg aggcaggacc ctggtgctgc caacagcgcg ctaccacccc agcatcgttt    22860

aaaagccggt ctttgtggtt cttgcagata tggccctcac ctgccgcctc cgtttcccgg    22920

tgccgggatt ccgaggaaga atgcaccgta ggaggggcat ggccggccac ggcctgacgg    22980

gcggcatgcg tcgtgcgcac caccggcggc ggcgcgcgtc gcaccgtcgc atgcgcggcg    23040

gtatcctgcc cctccttatt ccactgatcg ccgcggcgat tggcgccgtg cccggaattg    23100

catccgtggc cttgcaggcg cagagacact gattaaaaac aagttgcatg tggaaaaatc    23160

aaaataaaaa gtctggactc tcacgctcgc ttggtcctgt aactattttg tagaatggaa    23220

gacatcaact ttgcgtctct ggccccgcga cacggctcgc gcccgttcat gggaaactgg    23280

caagatatcg gcaccagcaa tatgagcggt ggcgccttca gctggggctc gctgtggagc    23340

ggcattaaaa atttcggttc caccgttaag aactatggca gcaaggcctg gaacagcagc    23400

acaggccaga tgctgaggga taagttgaaa gagcaaaatt tccaacaaaa ggtggtagat    23460

ggcctggcct ctggcattag cggggtggtg gacctggcca accaggcagt gcaaaataag    23520

attaacagta agcttgatcc ccgccctccc gtagaggagc ctccaccggc cgtggagaca    23580

gtgtctccag aggggcgtgg cgaaaagcgt ccgcgccccg acagggaaga aactctggtg    23640

acgcaaatag acgagcctcc ctcgtacgag gaggcactaa agcaaggcct gcccaccacc    23700

cgtcccatcg cgcccatggc taccggagtg ctgggccagc acacacccgt aacgctggac    23760

ctgcctcccc ccgccgacac ccagcagaaa cctgtgctgc caggcccgac cgccgttgtt    23820

gtaacccgtc ctagccgcgc gtccctgcgc cgcgccgcca gcggtccgcg atcgttgcgg    23880

cccgtagcca gtggcaactg gcaaagcaca ctgaacagca tcgtgggtct gggggtgcaa    23940

tccctgaagc gccgacgatg cttctgatag ctaacgtgtc gtatgtgtgt catgtatgcg    24000

tccatgtcgc cgccagagga gctgctgagc cgccgcgcgc ccgctttcca agatggctac    24060

cccttcgatg atgccgcagt ggtcttacat gcacatctcg ggccaggacg cctcggagta    24120

cctgagcccc gggctggtgc agtttgcccg cgccaccgag acgtacttca gcctgaataa    24180

caagtttaga aaccccacgg tggcgcctac gcacgacgtg accacagacc ggtcccagcg    24240

tttgacgctg cggttcatcc ctgtggaccg tgaggatact gcgtactcgt acaaggcgcg    24300

gttcacccta gctgtgggtg ataaccgtgt gctggacatg gcttccacgt actttgacat    24360

ccgcggcgtg ctggacaggg gccctacttt taagccctac tctggcactg cctacaacgc    24420

cctggctccc aagggtgccc caaatccttg cgaatgggat gaagctgcta ctgctcttga    24480

aataaaccta gaagaagagg acgatgacaa cgaagacgaa gtagacgagc aagctgagca    24540

gcaaaaaact cacgtatttg ggcaggcgcc ttattctggt ataaatatta caaaggaggg    24600

tattcaaata ggtgtcgaag gtcaaacacc taaatatgcc gataaaacat ttcaacctga    24660

acctcaaata ggagaatctc agtggtacga aacagaaatt aatcatgcag ctgggagagt    24720

cctaaaaaag actaccccaa tgaaaccatg ttacggttca tatgcaaaac ccacaaatga    24780

aaatggaggg caaggcattc ttgtaaagca acaaaatgga aagctagaaa gtcaagtgga    24840

aatgcaattt ttctcaacta ctgaggcagc cgcaggcaat ggtgataact tgactcctaa    24900

agtggtattg tacagtgaag atgtagatat agaaacccca gacactcata tttcttacat    24960

gcccactatt aaggaaggta actcacgaga actaatgggc caacaatcta tgcccaacag    25020

gcctaattac attgctttta gggacaattt tattggtcta atgtattaca acagcacggg    25080

taatatgggt gttctggcgg gccaagcatc gcagttgaat gctgttgtag atttgcaaga    25140

cagaaacaca gagctttcat accagctttt gcttgattcc attggtgata gaaccaggta    25200

cttttctatg tggaatcagg ctgttgacag ctatgatcca gatgttagaa ttattgaaaa    25260

tcatggaact gaagatgaac ttccaaatta ctgctttcca ctgggaggtg tgattaatac    25320

agagactctt accaaggtaa aacctaaaac aggtcaggaa aatggatggg aaaaagatgc    25380

tacagaattt tcagataaaa atgaaataag agttggaaat aattttgcca tggaaatcaa    25440

tctaaatgcc aacctgtgga gaaatttcct gtactccaac atagcgctgt atttgcccga    25500

caagctaaag tacagtcctt ccaacgtaaa aatttctgat aacccaaaca cctacgacta    25560

catgaacaag cgagtggtgg ctcccgggct agtggactgc tacattaacc ttggagcacg    25620

ctggtccctt gactatatgg acaacgtcaa cccatttaac caccaccgca atgctggcct    25680

gcgctaccgc tcaatgttgc tgggcaatgg tcgctatgtg cccttccaca tccaggtgcc    25740

tcagaagttc tttgccatta aaaacctcct tctcctgccg ggctcataca cctacgagtg    25800

gaacttcagg aaggatgtta acatggttct gcagagctcc ctaggaaatg acctaagggt    25860

tgacggagcc agcattaagt ttgatagcat ttgcctttac gccaccttct tccccatggc    25920

ccacaacacc gcctccacgc ttgaggccat gcttagaaac gacaccaacg accagtcctt    25980

taacgactat ctctccgccg ccaacatgct ctaccctata cccgccaacg ctaccaacgt    26040

gcccatatcc atcccctccc gcaactgggc ggctttccgc ggctgggcct tcacgcgcct    26100

taagactaag gaaaccccat cactgggctc gggctacgac ccttattaca cctactctgg    26160

ctctataccc tacctagatg gaacctttta cctcaaccac acctttaaga aggtggccat    26220

tacctttgac tcttctgtca gctggcctgg caatgaccgc ctgcttaccc ccaacgagtt    26280

tgaaattaag cgctcagttg acggggaggg ttacaacgtt gcccagtgta acatgaccaa    26340

agactggttc ctggtacaaa tgctagctaa ctataacatt ggctaccagg gcttctatat    26400

cccagagagc tacaaggacc gcatgtactc cttctttaga aacttccagc ccatgagccg    26460

tcaggtggtg gatgatacta aatacaagga ctaccaacag gtgggcatcc tacaccaaca    26520

caacaactct ggatttgttg gctaccttgc ccccaccatg cgcgaaggac aggcctaccc    26580

tgctaacttc ccctatccgc ttataggcaa gaccgcagtt gacagcatta cccagaaaaa    26640

gtttctttgc gatcgcaccc tttggcgcat cccattctcc agtaacttta tgtccatggg    26700

cgcactcaca gacctgggcc aaaaccttct ctacgccaac tccgcccacg cgctagacat    26760

gacttttgag gtggatccca tggacgagcc cacccttctt tatgttttgt ttgaagtctt    26820

tgacgtggtc cgtgtgcacc agccgcaccg cggcgtcatc gaaaccgtgt acctgcgcac    26880

gcccttctcg gccggcaacg ccacaacata aagaagcaag caacatcaac aacagctgcc    26940

gccatgggct ccagtgagca ggaactgaaa gccattgtca aagatcttgg ttgtgggcca    27000

tattttttgg gcacctatga caagcgcttt ccaggctttg tttctccaca caagctcgcc    27060

tgcgccatag tcaatacggc cggtcgcgag actgggggcg tacactggat ggcctttgcc    27120

tggaacccgc actcaaaaac atgctacctc tttgagccct ttggcttttc tgaccagcga    27180

ctcaagcagg tttaccagtt tgagtacgag tcactcctgc gccgtagcgc cattgcttct    27240

tcccccgacc gctgtataac gctggaaaag tccacccaaa gcgtacaggg gcccaactcg    27300

gccgcctgtg gactattctg ctgcatgttt ctccacgcct ttgccaactg gccccaaact    27360

cccatggatc acaaccccac catgaacctt attaccgggg tacccaactc catgctcaac    27420

agtccccagg tacagcccac cctgcgtcgc aaccaggaac agctctacag cttcctggag    27480

cgccactcgc cctacttccg cagccacagt gcgcagatta ggagcgccac ttctttttgt    27540

cacttgaaaa acatgtaaaa ataatgtact agagacactt tcaataaagg caaatgcttt    27600

tatttgtaca ctctcgggtg attatttacc cccacccttg ccgtctgcgc cgtttaaaaa    27660

tcaaaggggt tctgccgcgc atcgctatgc gccactggca gggacacgtt gcgatactgg    27720

tgtttagtgc tccacttaaa ctcaggcaca accatccgcg gcagctcggt gaagttttca    27780

ctccacaggc tgcgcaccat caccaacgcg tttagcaggt cgggcgccga tatcttgaag    27840

tcgcagttgg ggcctccgcc ctgcgcgcgc gagttgcgat acacagggtt gcagcactgg    27900

aacactatca gcgccgggtg gtgcacgctg gccagcacgc tcttgtcgga gatcagatcc    27960

gcgtccaggt cctccgcgtt gctcagggcg aacggagtca actttggtag ctgccttccc    28020

aaaaagggcg cgtgcccagg ctttgagttg cactcgcacc gtagtggcat caaaaggtga    28080

ccgtgcccgg tctgggcgtt aggatacagc gcctgcataa aagccttgat ctgcttaaaa    28140

gccacctgag cctttgcgcc ttcagagaag aacatgccgc aagacttgcc ggaaaactga    28200

ttggccggac aggccgcgtc gtgcacgcag caccttgcgt cggtgttgga gatctgcacc    28260

acatttcggc cccaccggtt cttcacgatc ttggccttgc tagactgctc cttcagcgcg    28320

cgctgcccgt tttcgctcgt cacatccatt tcaatcacgt gctccttatt tatcataatg    28380

cttccgtgta gacacttaag ctcgccttcg atctcagcgc agcggtgcag ccacaacgcg    28440

cagcccgtgg gctcgtgatg cttgtaggtc acctctgcaa acgactgcag gtacgcctgc    28500

aggaatcgcc ccatcatcgt cacaaaggtc ttgttgctgg tgaaggtcag ctgcaacccg    28560

cggtgctcct cgttcagcca ggtcttgcat acggccgcca gagcttccac ttggtcaggc    28620

agtagtttga agttcgcctt tagatcgtta tccacgtggt acttgtccat cagcgcgcgc    28680

gcagcctcca tgcccttctc ccacgcagac acgatcggca cactcagcgg gttcatcacc    28740

gtaatttcac tttccgcttc gctgggctct tcctcttcct cttgcgtccg cataccacgc    28800

gccactgggt cgtcttcatt cagccgccgc actgtgcgct tacctccttt gccatgcttg    28860

attagcaccg gtgggttgct gaaacccacc atttgtagcg ccacatcttc tctttcttcc    28920

tcgctgtcca cgattacctc tggtgatggc gggcgctcgg gcttgggaga agggcgcttc    28980

tttttcttct tgggcgcaat ggccaaatcc gccgccgagg tcgatggccg cgggctgggt    29040

gtgcgcggca ccagcgcgtc ttgtgatgag tcttcctcgt cctcggactc gatacgccgc    29100

ctcatccgct tttttggggg cgcccgggga ggcggcggcg acggggacgg ggacgacacg    29160

tcctccatgg ttgggggacg tcgcgccgca ccgcgtccgc gctcgggggt ggtttcgcgc    29220

tgctcctctt cccgactggc catttccttc tcctataggc agaaaaagat catggagtca    29280

gtcgagaaga aggacagcct aaccgccccc tctgagttcg ccaccaccgc ctccaccgat    29340

gccgccaacg cgcctaccac cttccccgtc gaggcacccc cgcttgagga ggaggaagtg    29400

attatcgagc aggacccagg ttttgtaagc gaagacgacg aggaccgctc agtaccaaca    29460

gaggataaaa agcaagacca ggacaacgca gaggcaaacg aggaacaagt cgggcggggg    29520

gacgaaaggc atggcgacta cctagatgtg ggagacgacg tgctgttgaa gcatctgcag    29580

cgccagtgcg ccattatctg cgacgcgttg caagagcgca gcgatgtgcc cctcgccata    29640

gcggatgtca gccttgccta cgaacgccac ctattctcac cgcgcgtacc ccccaaacgc    29700

caagaaaacg gcacatgcga gcccaacccg cgcctcaact tctaccccgt atttgccgtg    29760

ccagaggtgc ttgccaccta tcacatcttt ttccaaaact gcaagatacc cctatcctgc    29820

cgtgccaacc gcagccgagc ggacaagcag ctggccttgc ggcagggcgc tgtcatacct    29880

gatatcgcct cgctcaacga agtgccaaaa atctttgagg gtcttggacg cgacgagaag    29940

cgcgcggcaa acgctctgca acaggaaaac agcgaaaatg aaagtcactc tggagtgttg    30000

gtggaactcg agggtgacaa cgcgcgccta gccgtactaa aacgcagcat cgaggtcacc    30060

cactttgcct acccggcact taacctaccc cccaaggtca tgagcacagt catgagtgag    30120

ctgatcgtgc gccgtgcgca gcccctggag agggatgcaa atttgcaaga acaaacagag    30180

gagggcctac ccgcagttgg cgacgagcag ctagcgcgct ggcttcaaac gcgcgagcct    30240

gccgacttgg aggagcgacg caaactaatg atggccgcag tgctcgttac cgtggagctt    30300

gagtgcatgc agcggttctt tgctgacccg gagatgcagc gcaagctaga ggaaacattg    30360

cactacacct ttcgacaggg ctacgtacgc caggcctgca agatctccaa cgtggagctc    30420

tgcaacctgg tctcctacct tggaattttg cacgaaaacc gccttgggca aaacgtgctt    30480

cattccacgc tcaagggcga ggcgcgccgc gactacgtcc gcgactgcgt ttacttattt    30540

ctatgctaca cctggcagac ggccatgggc gtttggcagc agtgcttgga ggagtgcaac    30600

ctcaaggagc tgcagaaact gctaaagcaa aacttgaagg acctatggac ggccttcaac    30660

gagcgctccg tggccgcgca cctggcggac atcattttcc ccgaacgcct gcttaaaacc    30720

ctgcaacagg gtctgccaga cttcaccagt caaagcatgt tgcagaactt taggaacttt    30780

atcctagagc gctcaggaat cttgcccgcc acctgctgtg cacttcctag cgactttgtg    30840

cccattaagt accgcgaatg ccctccgccg ctttggggcc actgctacct tctgcagcta    30900

gccaactacc ttgcctacca ctctgacata atggaagacg tgagcggtga cggtctactg    30960

gagtgtcact gtcgctgcaa cctatgcacc ccgcaccgct ccctggtttg caattcgcag    31020

ctgcttaacg aaagtcaaat tatcggtacc tttgagctgc agggtccctc gcctgacgaa    31080

aagtccgcgg ctccggggtt gaaactcact ccggggctgt ggacgtcggc ttaccttcgc    31140

aaatttgtac ctgaggacta ccacgcccac gagattaggt tctacgaaga ccaatcccgc    31200

ccgcctaatg cggagcttac cgcctgcgtc attacccagg gccacattct tggccaattg    31260

caagccatca acaaagcccg ccaagagttt ctgctacgaa agggacgggg ggtttacttg    31320

gacccccagt ccggcgagga gctcaaccca atccccccgc cgccgcagcc ctatcagcag    31380

cagccgcggg cccttgcttc ccaggatggc acccaaaaag aagctgcagc tgccgccgcc    31440

acccacggac gaggaggaat actgggacag tcaggcagag gaggttttgg acgaggagga    31500

ggaggacatg atggaagact gggagagcct agacgaggaa gcttccgagg tcgaagaggt    31560

gtcagacgaa acaccgtcac cctcggtcgc attcccctcg ccggcgcccc agaaatcggc    31620

aaccggttcc agcatggcta caacctccgc tcctcaggcg ccgccggcac tgcccgttcg    31680

ccgacccaac cgtagatggg acaccactgg aaccagggcc ggtaagtcca agcagccgcc    31740

gccgttagcc caagagcaac aacagcgcca aggctaccgc tcatggcgcg ggcacaagaa    31800

cgccatagtt gcttgcttgc aagactgtgg gggcaacatc tccttcgccc gccgctttct    31860

tctctaccat cacggcgtgg ccttcccccg taacatcctg cattactacc gtcatctcta    31920

cagcccatac tgcaccggcg gcagcggcag caacagcagc ggccacacag aagcaaaggc    31980

gaccggatag caagactctg acaaagccca agaaatccac agcggcggca gcagcaggag    32040

gaggagcgct gcgtctggcg cccaacgaac ccgtatcgac ccgcgagctt agaaacagga    32100

tttttcccac tctgtatgct atatttcaac agagcagggg ccaagaacaa gagctgaaaa    32160

taaaaaacag gtctctgcga tccctcaccc gcagctgcct gtatcacaaa agcgaagatc    32220

agcttcggcg cacgctggaa gacgcggagg ctctcttcag taaatactgc gcgctgactc    32280

ttaaggacta gtttcgcgcc ctttctcaaa tttaagcgcg aaaactacgt catctccagc    32340

ggccacaccc ggcgccagca cctgttgtca gcgccattat gagcaaggaa attcccacgc    32400

cctacatgtg gagttaccag ccacaaatgg gacttgcggc tggagctgcc caagactact    32460

caacccgaat aaactacatg agcgcgggac cccacatgat atcccgggtc aacggaatac    32520

gcgcccaccg aaaccgaatt ctcctggaac aggcggctat taccaccaca cctcgtaata    32580

accttaatcc ccgtagttgg cccgctgccc tggtgtacca ggaaagtccc gctcccacca    32640

ctgtggtact tcccagagac gcccaggccg aagttcagat gactaactca ggggcgcagc    32700

ttgcgggcgg ctttcgtcac agggtgcggt cgcccgggca gggtataact cacctgacaa    32760

tcagagggcg aggtattcag ctcaacgacg agtcggtgag ctcctcgctt ggtctccgtc    32820

cggacgggac atttcagatc ggcggcgccg gccgctcttc attcacgcct cgtcaggcaa    32880

tcctaactct gcagacctcg tcctctgagc cgcgctctgg aggcattgga actctgcaat    32940

ttattgagga gtttgtgcca tcggtctact ttaacccctt ctcgggacct cccggccact    33000

atccggatca atttattcct aactttgacg cggtaaagga ctcggcggac ggctacgact    33060

gaatgttaag tggagaggca gagcaactgc gcctgaaaca cctggtccac tgtcgccgcc    33120

acaagtgctt tgcccgcgac tccggtgagt tttgctactt tgaattgccc gaggatcata    33180

tcgagggccc ggcgcacggc gtccggctta ccgcccaggg agagcttgcc cgtagcctga    33240

ttcgggagtt tacccagcgc cccctgctag ttgagcggga caggggaccc tgtgttctca    33300

ctgtgatttg caactgtcct aaccctggat tacatcaaga tcctctagtt aatgtcaggt    33360

cgcctaagtc gattaactag agtacccggg gatcttattc cctttaacta ataaaaaaaa    33420

ataataaagc atcacttact taaaatcagt tagcaaattt ctgtccagtt tattcagcag    33480

cacctccttg ccctcctccc agctctggta ttgcagcttc ctcctggctg caaactttct    33540

ccacaatcta aatggaatgt cagtttcctc ctgttcctgt ccatccgcac ccactatctt    33600

catgttgttg cagatgaagc gcgcaagacc gtctgaagat accttcaacc ccgtgtatcc    33660

atatgacacg gaaaccggtc ctccaactgt gccttttctt actcctccct ttgtatcccc    33720

caatgggttt caagagagtc cccctggggt actctctttg cgcctatccg aacctctagt    33780

tacctccaat ggcatgcttg cgctcaaaat gggcaacggc ctctctctgg acgaggccgg    33840

caaccttacc tcccaaaatg taaccactgt gagcccacct ctcaaaaaaa ccaagtcaaa    33900

cataaacctg gaaatatctg cacccctcac agttacctca gaagccctaa ctgtggctgc    33960

cgccgcacct ctaatggtcg cgggcaacac actcaccatg caatcacagg ccccgctaac    34020

cgtgcacgac tccaaactta gcattgccac ccaaggaccc ctcacagtgt cagaaggaaa    34080

gctagccctg caaacatcag gccccctcac caccaccgat agcagtaccc ttactatcac    34140

tgcctcaccc cctctaacta ctgccactgg tagcttgggc attgacttga aagagcccat    34200

ttatacacaa aatggaaaac taggactaaa gtacggggct cctttgcatg taacagacga    34260

cctaaacact ttgaccgtag caactggtcc aggtgtgact attaataata cttccttgca    34320

aactaaagtt actggagcct tgggttttga ttcacaaggc aatatgcaac ttaatgtagc    34380

aggaggacta aggattgatt ctcaaaacag acgccttata cttgatgtta gttatccgtt    34440

tgatgctcaa aaccaactaa atctaagact aggacagggc cctcttttta taaactcagc    34500

ccacaacttg gatattaact acaacaaagg cctttacttg tttacagctt caaacaattc    34560

caaaaagctt gaggttaacc taagcactgc caaggggttg atgtttgacg ctacagccat    34620

agccattaat gcaggagatg ggcttgaatt tggttcacct aatgcaccaa acacaaatcc    34680

cctcaaaaca aaaattggcc atggcctaga atttgattca aacaaggcta tggttcctaa    34740

actaggaact ggccttagtt ttgacagcac aggtgccatt acagtaggaa acaaaaataa    34800

tgataagcta actttgtgga ccacaccagc tccatctcct aactgtagac taaatgcaga    34860

gaaagatgct aaactcactt tggtcttaac aaaatgtggc agtcaaatac ttgctacagt    34920

ttcagttttg gctgttaaag gcagtttggc tccaatatct ggaacagttc aaagtgctca    34980

tcttattata agatttgacg aaaatggagt gctactaaac aattccttcc tggacccaga    35040

atattggaac tttagaaatg gagatcttac tgaaggcaca gcctatacaa acgctgttgg    35100

atttatgcct aacctatcag cttatccaaa atctcacggt aaaactgcca aaagtaacat    35160

tgtcagtcaa gtttacttaa acggagacaa aactaaacct gtaacactaa ccattacact    35220

aaacggtaca caggaaacag gagacacaac tccaagtgca tactctatgt cattttcatg    35280

ggactggtct ggccacaact acattaatga aatatttgcc acatcctctt acactttttc    35340

atacattgcc caagaataaa gaatcgtttg tgttatgttt caacgtgttt atttttcaat    35400

tgcagaaaat ttcaagtcat ttttcattca gtagtatagc cccaccacca catagcttat    35460

acagatcacc gtaccttaat caaactcaca gaaccctagt attcaacctg ccacctccct    35520

cccaacacac agagtacaca gtcctttctc cccggctggc cttaaaaagc atcatatcat    35580

gggtaacaga catattctta ggtgttatat tccacacggt ttcctgtcga gccaaacgct    35640

catcagtgat attaataaac tccccgggca gctcacttaa gttcatgtcg ctgtccagct    35700

gctgagccac aggctgctgt ccaacttgcg gttgcttaac gggcggcgaa ggagaagtcc    35760

acgcctacat gggggtagag tcataatcgt gcatcaggat agggcggtgg tgctgcagca    35820

gcgcgcgaat aaactgctgc cgccgccgct ccgtcctgca ggaatacaac atggcagtgg    35880

tctcctcagc gatgattcgc accgcccgca gcataaggcg ccttgtcctc cgggcacagc    35940

agcgcaccct gatctcactt aaatcagcac agtaactgca gcacagcacc acaatattgt    36000

tcaaaatccc acagtgcaag gcgctgtatc caaagctcat ggcggggacc acagaaccca    36060

cgtggccatc ataccacaag cgcaggtaga ttaagtggcg acccctcata aacacgctgg    36120

acataaacat tacctctttt ggcatgttgt aattcaccac ctcccggtac catataaacc    36180

tctgattaaa catggcgcca tccaccacca tcctaaacca gctggccaaa acctgcccgc    36240

cggctataca ctgcagggaa ccgggactgg aacaatgaca gtggagagcc caggactcgt    36300

aaccatggat catcatgctc gtcatgatat caatgttggc acaacacagg cacacgtgca    36360

tacacttcct caggattaca agctcctccc gcgttagaac catatcccag ggaacaaccc    36420

attcctgaat cagcgtaaat cccacactgc agggaagacc tcgcacgtaa ctcacgttgt    36480

gcattgtcaa agtgttacat tcgggcagca gcggatgatc ctccagtatg gtagcgcggg    36540

tttctgtctc aaaaggaggt agacgatccc tactgtacgg agtgcgccga gacaaccgag    36600

atcgtgttgg tcgtagtgtc atgccaaatg gaacgccgga cgtagtcata tttcctgaag    36660

caaaaccagg tgcgggcgtg acaaacagat ctgcgtctcc ggtctcgccg cttagatcgc    36720

tctgtgtagt agttgtagta tatccactct ctcaaagcat ccaggcgccc cctggcttcg    36780

ggttctatgt aaactccttc atgcgccgct gccctgataa catccaccac cgcagaataa    36840

gccacaccca gccaacctac acattcgttc tgcgagtcac acacgggagg agcgggaaga    36900

gctggaagaa ccatgttttt ttttttattc caaaagatta tccaaaacct caaaatgaag    36960

atctattaag tgaacgcgct cccctccggt ggcgtggtca aactctacag ccaaagaaca    37020

gataatggca tttgtaagat gttgcacaat ggcttccaaa aggcaaacgg ccctcacgtc    37080

caagtggacg taaaggctaa acccttcagg gtgaatctcc tctataaaca ttccagcacc    37140

ttcaaccatg cccaaataat tctcatctcg ccaccttctc aatatatctc taagcaaatc    37200

ccgaatatta agtccggcca ttgtaaaaat ctgctccaga gcgccctcca ccttcagcct    37260

caagcagcga atcatgattg caaaaattca ggttcctcac agacctgtat aagattcaaa    37320

agcggaacat taacaaaaat accgcgatcc cgtaggtccc ttcgcagggc cagctgaaca    37380

taatcgtgca ggtctgcacg gaccagcgcg gccacttccc cgccaggaac catgacaaaa    37440

gaacccacac tgattatgac acgcatactc ggagctatgc taaccagcgt agccccgatg    37500

taagcttgtt gcatgggcgg cgatataaaa tgcaaggtgc tgctcaaaaa atcaggcaaa    37560

gcctcgcgca aaaaagaaag cacatcgtag tcatgctcat gcagataaag gcaggtaagc    37620

tccggaacca ccacagaaaa agacaccatt tttctctcaa acatgtctgc gggtttctgc    37680

ataaacacaa aataaaataa caaaaaaaca tttaaacatt agaagcctgt cttacaacag    37740

gaaaaacaac ccttataagc ataagacgga ctacggccat gccggcgtga ccgtaaaaaa    37800

actggtcacc gtgattaaaa agcaccaccg acagctcctc ggtcatgtcc ggagtcataa    37860

tgtaagactc ggtaaacaca tcaggttgat tcacatcggt cagtgctaaa aagcgaccga    37920

aatagcccgg gggaatacat acccgcaggc gtagagacaa cattacagcc cccataggag    37980

gtataacaaa attaatagga gagaaaaaca cataaacacc tgaaaaaccc tcctgcctag    38040

gcaaaatagc accctcccgc tccagaacaa catacagcgc ttccacagcg gcagccataa    38100

cagtcagcct taccagtaaa aaagaaaacc tattaaaaaa acaccactcg acacggcacc    38160

agctcaatca gtcacagtgt aaaaaagggc caagtgcaga gcgagtatat ataggactaa    38220

aaaatgacgt aacggttaaa gtccacaaaa aacacccaga aaaccgcacg cgaacctacg    38280

cccagaaacg aaagccaaaa aacccacaac ttcctcaaat cgtcacttcc gttttcccac    38340

gttacgtcac ttcccatttt aagaaaacta caattcccaa cacatacaag ttactccgcc    38400

ctaaaaccta cgtcacccgc cccgttccca cgccccgcgc cacgtcacaa actccacccc    38460

ctcattatca tattggcttc aatccaaaat aaggta                              38496


<210>  233
<211>  9701
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  vector for IgG1 against T27Y H34A R273Q ACE2 mutant


<220>
<221>  misc_feature
<222>  (2929)..(2930)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (2934)..(2934)
<223>  n is a, c, g, or t

<400>  233
ggcgtaatct gctgcttgca aacaaaaaaa ccaccgctac cagcggtggt ttgtttgccg       60

gatcaagagc taccaactct ttttccgaag gtaactggct tcagcagagc gcagatacca      120

aatactgtcc ttctagtgta gccgtagtta ggccaccact tcaagaactc tgtagcaccg      180

cctacatacc tcgctctgct gaagccagtt accagtggct gctgccagtg gcgataagtc      240

gtgtcttacc gggttggact caagagatag ttaccggata aggcgcagcg gtcgggctga      300

acggggggtt cgtgcacaca gcccagcttg gagcgaacga cctacaccga actgagatac      360

ctacagcgtg agctatgaga aagcgccacg cttcccgaag ggagaaaggc ggacaggtat      420

ccggtaagcg gcagggtcgg aacaggagag cgcacgaggg agcttccagg gggaaacgcc      480

tggtatcttt atagtcctgt cgggtttcgc cacctctgac ttgagcgtcg atttttgtga      540

tgctcgtcag gggggcggag cctatggaaa aacgccagca acgcaagcta gagtttaaac      600

ttgacagatg agacaataac cctgataaat gcttcaataa tattgaaaaa ggaaaagtat      660

gagtattcaa catttccgtg tcgcccttat tccctttttt gcggcatttt gccttcctgt      720

ttttgctcac ccagaaacgc tggtgaaagt aaaagatgca gaagatcact tgggtgcgcg      780

agtgggttac atcgaactgg atctcaacag cggtaagatc cttgagagtt ttcgccccga      840

agaacgtttc ccaatgatga gcacttttaa agttctgcta tgtggcgcgg tattatcccg      900

tattgatgcc gggcaagagc aactcggtcg ccgcatacac tattctcaga atgacttggt      960

tgaatactca ccagtcacag aaaagcatct tacggatggc atgacagtaa gagaattatg     1020

cagtgctgcc ataaccatga gtgataacac tgcggccaac ttacttctga caactatcgg     1080

aggaccgaag gagctaaccg cttttttgca caacatgggg gatcatgtaa ctcgccttga     1140

tcgttgggaa ccggagctga atgaagccat accaaacgac gagcgtgaca ccacgatgcc     1200

tgtagcaatg gcaacaacgt tgcgaaaact attaactggc gaactactta ctctagcttc     1260

ccggcaacaa ctaatagact ggatggaggc ggataaagtt gcaggaccac ttctgcgctc     1320

ggcacttccg gctggctggt ttattgctga taaatcagga gccggtgagc gtgggtcacg     1380

cggtatcatt gcagcactgg ggccggatgg taagccctcc cgtatcgtag ttatctacac     1440

tacggggagt caggcaacta tggatgaacg aaatagacag atcgctgaga taggtgcctc     1500

actgattaag cattggtaag gataaatttc tggtaaggag gacacgtatg gaagtgggca     1560

agttggggaa gccgtatccg ttgctgaatc tggcatatgt gggagtataa gacgcgcagc     1620

gtcgcatcag gcattttttt ctgcgccaat gcaaaaaggc catccgtcag gatggccttt     1680

cggcataact agggccgccg atatttgaaa atatggcata ttgaaaatgt cgccgatgtg     1740

agtttctgtg taactgatat cgccattttt ccaaaagtga tttttgggca tacgcgatat     1800

ctggcgatag cgcttatatc gtttacgggg gatggcgata gacgactttg gtgacttggg     1860

cgattctgtg tgtcgcaaat atcgcagttt cgatataggt gacagacgat atgaggctat     1920

atcgccgata gaggcgacat caagctggca catggccaat gcatatcgat ctatacattg     1980

aatcaatatt ggccattagc catattattc attggttata tagcataaat caatattggc     2040

tattggccat tgcatacgtt gtatccatat cataatatgt acatttatat tggctcatgt     2100

ccaacattac cgccatgttg acattgatta ttgactagtt attaatagta atcaattacg     2160

gggtcattag ttcatagccc atatatggag ttccgcgtta cataacttac ggtaaatggc     2220

ccgcctggct gaccgcccaa cgacccccgc ccattgacgt caataatgac gtatgttccc     2280

atagtaacgc caatagggac tttccattga cgtcaatggg tggagtattt acggtaaact     2340

gcccacttgg cagtacatca agtgtatcat atgccaagta cgccccctat tgacgtcaat     2400

gacggtaaat ggcccgcctg gcattatgcc cagtacatga ccttatggga ctttcctact     2460

tggcagtaca tctacgtatt agtcatcgct attaccatgg tgatgcggtt ttggcagtac     2520

atcaatgggc gtggatagcg gtttgactca cggggatttc caagtctcca ccccattgac     2580

gtcaatggga gtttgttttg gcaccaaaat caacgggact ttccaaaatg tcgtaacaac     2640

tccgccccat tgacgcaaat gggcggtagg cgtgtacggt gggaggtcta tataagcaga     2700

gctcgtttag tgaaccgtca gatcgcctgg agacgccatc cacgctgttt tgacctccat     2760

agaagacacc gggaccgatc cagcctccgc ggccgggaac ggtgcattgg aacgcggatt     2820

ccccgtgcca agagtgacgt aagtaccgcc tatagagtct ataggcccac ccccttggct     2880

tcttatgcat gctatactgt ttttggcttg gggtctatac accccccgnn ttcntcatgt     2940

tataggtgat ggtatagctt agcctatagg tgtgggttat tgaccattat tgaccactcc     3000

ccctattggt gacgatactt tccattacta atccataaca tggctctttg ccacaactct     3060

ctttattggc tatatgccaa tacactgtcc ttcagagact gacacggact ctgtattttt     3120

acaggatggg gtctcattta ttatttacaa attcacatat acaacaccac cgtccccagt     3180

gcccgcagtt tttattaaac ataacgtggg atctccacgc gaatctcggg tacgtgttcc     3240

ggacatgggc tcttctccgg tagcggcgga gcttctacat ccgagccctg ctcccatgcc     3300

tccagcgact catggtcgct cggcagctcc ttgctcctaa cagtggaggc cagacttagg     3360

cacagcacga tgcccaccac caccagtgtg ccgcacaagg ccgtggcggt agggtatgtg     3420

tctgaaaatg agctcgggga gcgggcttgc accgctgacg catttggaag acttaaggca     3480

gcggcagaag aagatgcagg cagctgagtt gttgtgttct gataagagtc agaggtaact     3540

cccgttgcgg tgctgttaac ggtggagggc agtgtagtct gagcagtact cgttgctgcc     3600

gcgcgcgcca ccagacataa tagctgacag actaacagac tgttcctttc catgggtctt     3660

ttctgcagtc accgtccttg acacgaagct gctagcgcca ccatgagcag cagtagttgg     3720

cttctcttga gtttggtggc agtgacagca gcccagagta ctatcgagga gcaggctaaa     3780

tactttctgg ataagtttaa cgccgaggcc gaagacttgt tctatcaatc ttctctcgct     3840

tcatggaatt acaatactaa catcactgag gagaacgtcc agaatatgaa caatgctggc     3900

gacaaatgga gcgccttctt gaaggagcag tctacccttg cacaaatgta tccactgcag     3960

gagatacaga accttacagt aaagttgcag ctccaggctc tccagcagaa cggatctagc     4020

gtgctttcag aggataaaag caaaaggctg aacaccatac ttaataccat gtccacaatt     4080

tactctactg gtaaagtatg taaccccgac aaccctcaag aatgcctcct tcttgagcca     4140

ggcctcaatg agatcatggc taatagtctg gactataatg aaagactgtg ggcatgggag     4200

tcctggagat ctgaagtagg gaagcaactg aggccccttt atgaagagta cgtcgtactt     4260

aagaatgaaa tggcccgcgc taaccactac gaggattacg gcgattactg gcgtggggac     4320

tatgaagtaa atggtgtaga tggatacgac tatagtcgtg ggcaattgat tgaggatgtg     4380

gagcacactt ttgaggagat aaaaccactc tatgagcatc ttcacgcata tgtgagagct     4440

aaactgatga acgcctaccc aagttacatc agtccaatcg gatgtctccc agctcacctc     4500

cttggcgaca tgtggggaca gttctggacc aatctgtatt ccctcacagt ccctttcggg     4560

caaaagccta atatagacgt gacagacgca atggttgatc aggcttggga tgctcaaagg     4620

atttttaagg aagctgagaa gttttttgtg tcagtcggtt tgccaaatat gacacaaggc     4680

ttctgggaaa atagcatgtt gactgatccc ggtaatgttc aaaaggctgt gtgtcaccct     4740

accgcttggg accttgggaa aggtgacttt cgaatcttga tgtgtaccaa ggtgacaatg     4800

gatgactttc ttacagccca tcatgaaatg ggtcacatcc agtatgatat ggcttatgca     4860

gctcaacctt tcctcttgag aaatggtgca aatgaaggtt ttcatgaagc tgtaggggaa     4920

ataatgtccc tgagtgctgc aaccccaaag catctcaaga gtatcggatt gttgagccca     4980

gattttcaag aagataacga gaccgaaatc aacttccttc tgaaacaagc cctcacaata     5040

gttggtactc ttccattcac atacatgctg gagaaatggc gttggatggt ttttaagggg     5100

gagataccta aagatcagtg gatgaaaaag tggtgggaga tgaagcgtga gatcgtaggg     5160

gtcgtggagc cagtgcctca tgatgagact tactgtgacc cagcatcact cttccacgtt     5220

agcaatgact attcatttat acgttattac actcgcactc tttaccagtt tcaatttcag     5280

gaggctctgt gtcaggctgc caagcatgag ggaccccttc acaagtgtga tattagtaac     5340

agtactgagg caggccaaaa actgttcaat atgttgaggc ttggcaaaag cgagccatgg     5400

actctcgcct tggaaaatgt tgtcggggct aaaaacatga atgtacgccc tctgcttaac     5460

tattttgagc ccctttttac atggctcaag gaccagaata agaactcctt tgtcggctgg     5520

tcaacagact ggtctcccta tgcagacaaa acacatactt gcccaccttg tcctgcacca     5580

gagctgctgg gaggtccaag cgtgttcctg tttccaccca agcccaaaga cacactgatg     5640

atttctcgaa ctccagaagt gacctgcgtg gtcgtggacg tgagccacga ggatcccgaa     5700

gtgaagttca actggtacgt ggatggcgtg gaggtccata atgctaagac taaaccccgg     5760

gaggaacagt acaacagcac ttatagggtc gtgtccgtgc tgaccgtcct gcatcaggat     5820

tggctgaacg ggaaggaata taagtgcaaa gtgtctaata aggcactgcc cgcccctatc     5880

gagaaaacaa ttagcaaggc taagggtcag cctagagaac cacaggtgta cactctgcct     5940

ccaagtcgcg acgagctgac caagaaccag gtgtcactga catgtctggt caaaggcttt     6000

tatccctcag atatcgcagt ggagtgggaa agcaatggac agcctgagaa caattacaag     6060

accacacccc ctgtgctgga cagtgatggc tcattctttc tgtattctaa gctgacagtg     6120

gacaaaagta ggtggcagca gggaaacgtg ttctcctgct ctgtcatgca cgaagcactg     6180

cacaatcatt atacccagaa gagtctgtca ctgagccctg gcaaatgagc gataccgatt     6240

ctagaactag atcataatca gccataccac atttgtagag gttttacttg ctttaaaaaa     6300

cctcccacac ctccccctga acctgaaaca taaaatgaat gcaattgttg ttgttaactt     6360

gtttattgca gcttataatg gttacaaata aagcaatagc atcacaaatt tcacaaataa     6420

agcatttttt tcactgcatt ctagttgtgg tttgtccaaa ctcatcaatg tatcttaagg     6480

ccgcaggtaa gccagcccag gcctcgccct ccagctcaag gcgggacagg tgccctagag     6540

tagcctgcat ccagggacag gccccagccg ggtgctgaca cgtccacctc catctcttcc     6600

tcaggtctgc ccgggtggca tccctgtgac ccctccccag tgcctctcct ggtcgtggaa     6660

ggtgctactc cagtgcccac cagccttgtc ctaataaaat taagttgcat cattttgttt     6720

gactaggtgt ccttgtataa tattatgggg tggaggcggg tggtatggag caaggggccc     6780

aagttaactt gtttattgca gcttataatg gttacaaata aagcaatagc atcacaaatt     6840

tcacaaataa agcatttttt tcactgcatt ctagttgtgg tttgtccaaa ctcatcaatg     6900

tatcttatca tgtctggatc cgcttcaggc accgggcttg cgggtcatgc accaggtgcg     6960

cggtccttcg ggcacctcga cgtcggcggt gacggtgaag ccgagccgct cgtagaaggg     7020

gaggttgcgg ggcgcggagg tctccaggaa ggcgggcacc ccggcgcgct cggccgcctc     7080

cactccgggg agcacgacgg cgctgcccag acccttgccc tggtggtcgg gcgagacgcc     7140

gacggtggcc aggaaccacg cgggctcctt gggccggtgc ggcgccagga ggccttccat     7200

ctgttgctgc gcggccagcc tggaaccgct caactcggcc atgcgcgggc cgatctcggc     7260

gaacaccgcc cccgcttcga cgctctccgg cgtggtccag accgccaccg cggcgccgtc     7320

gtccgcgacc cacaccttgc cgatgtcgag cccgacgcgc gtgaggaaga gttcttgcag     7380

ctcggtgacc cgctcgatgt ggcggtccgg gtcgacggtg tggcgcgtgg cggggtagtc     7440

ggcgaacgcg gcggcgaggg tgcgtacggc ccgggggacg tcgtcgcggg tggcgaggcg     7500

caccgtgggc ttgtactcgg tcatggtggc ctgcagagtc gctctgtgtt cgaggccaca     7560

cgcgtcacct taatatgcga agtggacctg ggaccgcgcc gccccgactg catctgcgtg     7620

ttttcgccaa tgacaagacg ctgggcgggg tttgtgtcat catagaacta aagacatgca     7680

aatatatttc ttccggggac accgccagca aacgcgagca acgggccacg gggatgaagc     7740

agctgcgcca ctccctgaag atccatcgtc tcctaacaag ttacatcact cctgcccttc     7800

ctcaccctca tctccatcac ctccttcatc tccgtcatct ccgtcatcac cctccgcggc     7860

agccccttcc accataggtg gaaaccaggg aggcaaatct actccatcgt caaagctgca     7920

cacagtcacc ctgatattgc aggtaggagc gggctttgtc ataacaaggt ccttaatcgc     7980

atccttcaaa acctcagcaa atatatgagt ttgtaaaaag accatgaaat aacagacaat     8040

ggactccctt agcgggccag gttgtgggcc gggtccaggg gccattccaa aggggagacg     8100

actcaatggt gtaagacgac attgtggaat agcaagggca gttcctcgcc ttaggttgta     8160

aagggaggtc ttactacctc catatacgaa cacaccggcg acccaagttc cttcgtcggt     8220

agtcctttct acgtgactcc tagccaggag agctcttaaa ccttctgcaa tgttctcaaa     8280

tttcgggttg gaacctcctt gaccacgatg ctttccaaac caccctcctt ttttgcgcct     8340

gcctccatca ccctgacccc cgctgcgcgg gggcacgtca ggctcaccat ctgggccgcc     8400

ttcttggtgg tattcaaaat aatcggcttc ccctacaggg tggaaaaatg gccttctacc     8460

tggagggggc ctgcgcggtg gagacccgga tgatgatgac tgactactgg gactcctggg     8520

cctcttttct ccacgtccac gacctctccc cctggctctt tcacgacttc cccccctggc     8580

tctttcacgt cctctacccc ggcggcctcc actacctcct cgaccccggc ctccactacc     8640

tcctcgaccc cggcctccac tgcctcctcg accccggcct ccacctcctg ctcctgcccc     8700

tcccgctcct gctcctgctc ctgttccacc gtgggtccct ttgcagccaa tgcaacttgg     8760

acgtttttgg ggtctccgga caccatctct atgtcttggc cctgatcctg agccgcccgg     8820

ggctcctggt cttccgcctc ctcgtcctcg tcctcttccc cgtcctcgtc catgtgccat     8880

gatggcggcc tgcagctgtg ttcgaggccg cgcgtgtcac cttaatatgc gaagtggacc     8940

tgggaccgcg ccgccccgac tgcatctgcg tgttcgagtt cgccaatgac aagacgctgg     9000

gcggggagat cccccttatt aaccctaaac gggtagcata tgcttcccgg gtagtagtat     9060

atactatcca gactaaccct aattcaatag catatgttac ccaacgggaa gcatatgcta     9120

tcgaattagg gttagtaaaa gggtcctaag gaacagcgat ctggatagca tatgctatcc     9180

taatctatat ctgggtagca tatgctatcc taatctatat ctgggtagca taggctatcc     9240

taatctatat ctgggtagca tatgctatcc taatctatat ctgggtagta tatgctatcc     9300

taatttatat ctgggtagca taggctatcc taatctatat ctgggtagca tatgctatcc     9360

taatctatat ctgggtagta tatgctatcc taatctgtat ccgggtagca tatgctatcc     9420

tcatgcatat acagtcagca tatgataccc agtagtagag tgggagtgct atcctttgca     9480

tatgccgcca cctcccaagg agatctgtcg acatcgatgg gcgcgggtgt acactccgcc     9540

catcccgccc ctaactccgc ccagttccgc ccattctccg cctcatggct gactaatttt     9600

ttttatttat gcagaggccg aggccgcctc ggcctctgag ctattccaga agtagtgagg     9660

aggctttttt ggaggcctag gcttttgcaa aaagctaatt c                         9701


<210>  234
<211>  841
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ACE2-Fc IgG Hybrid Protein


<220>
<221>  misc_feature
<222>  (1)..(776)
<223>  ACE2 Portion

<220>
<221>  misc_feature
<222>  (777)..(841)
<223>  IgG Fc Portion

<400>  234

Met Ser Ser Ser Ser Trp Leu Leu Leu Ser Leu Val Ala Val Thr Ala 
1               5                   10                  15      


Ala Gln Ser Thr Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Lys Phe 
            20                  25                  30          


Asn His Glu Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ser Trp 
        35                  40                  45              


Asn Tyr Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn 
    50                  55                  60                  


Ala Gly Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Leu Ala 
65                  70                  75                  80  


Gln Met Tyr Pro Leu Gln Glu Ile Gln Asn Leu Thr Val Lys Leu Gln 
                85                  90                  95      


Leu Gln Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys 
            100                 105                 110         


Ser Lys Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser 
        115                 120                 125             


Thr Gly Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu 
    130                 135                 140                 


Glu Pro Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu 
145                 150                 155                 160 


Arg Leu Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu 
                165                 170                 175     


Arg Pro Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg 
            180                 185                 190         


Ala Asn His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu 
        195                 200                 205             


Val Asn Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu 
    210                 215                 220                 


Asp Val Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu 
225                 230                 235                 240 


His Ala Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile 
                245                 250                 255     


Ser Pro Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly 
            260                 265                 270         


Arg Phe Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys 
        275                 280                 285             


Pro Asn Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala 
    290                 295                 300                 


Gln Arg Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu 
305                 310                 315                 320 


Pro Asn Met Thr Gln Gly Phe Trp Glu Asn Ser Met Leu Thr Asp Pro 
                325                 330                 335     


Gly Asn Val Gln Lys Ala Val Cys His Pro Thr Ala Trp Asp Leu Gly 
            340                 345                 350         


Lys Gly Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp 
        355                 360                 365             


Phe Leu Thr Ala His His Glu Met Gly His Ile Gln Tyr Asp Met Ala 
    370                 375                 380                 


Tyr Ala Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe 
385                 390                 395                 400 


His Glu Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys 
                405                 410                 415     


His Leu Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn 
            420                 425                 430         


Glu Thr Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly 
        435                 440                 445             


Thr Leu Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe 
    450                 455                 460                 


Lys Gly Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met 
465                 470                 475                 480 


Lys Arg Glu Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr 
                485                 490                 495     


Tyr Cys Asp Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe 
            500                 505                 510         


Ile Arg Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala 
        515                 520                 525             


Leu Cys Gln Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile 
    530                 535                 540                 


Ser Asn Ser Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu 
545                 550                 555                 560 


Gly Lys Ser Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala 
                565                 570                 575     


Lys Asn Met Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe 
            580                 585                 590         


Thr Trp Leu Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr 
        595                 600                 605             


Asp Trp Ser Pro Tyr Ala Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
    610                 615                 620                 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
625                 630                 635                 640 


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
                645                 650                 655     


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
            660                 665                 670         


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
        675                 680                 685             


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
    690                 695                 700                 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
705                 710                 715                 720 


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
                725                 730                 735     


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
            740                 745                 750         


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
        755                 760                 765             


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
    770                 775                 780                 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
785                 790                 795                 800 


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
                805                 810                 815     


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
            820                 825                 830         


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        835                 840     


<210>  235
<211>  841
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ACE2-Fc IgG R273Q Hybrid Protein


<220>
<221>  misc_feature
<222>  (1)..(776)
<223>  ACE2 Portion with R273Q mutation

<220>
<221>  misc_feature
<222>  (777)..(841)
<223>  IgG Fc Portion

<400>  235

Met Ser Ser Ser Ser Trp Leu Leu Leu Ser Leu Val Ala Val Thr Ala 
1               5                   10                  15      


Ala Gln Ser Thr Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Lys Phe 
            20                  25                  30          


Asn His Glu Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ser Trp 
        35                  40                  45              


Asn Tyr Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn 
    50                  55                  60                  


Ala Gly Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Leu Ala 
65                  70                  75                  80  


Gln Met Tyr Pro Leu Gln Glu Ile Gln Asn Leu Thr Val Lys Leu Gln 
                85                  90                  95      


Leu Gln Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys 
            100                 105                 110         


Ser Lys Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser 
        115                 120                 125             


Thr Gly Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu 
    130                 135                 140                 


Glu Pro Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu 
145                 150                 155                 160 


Arg Leu Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu 
                165                 170                 175     


Arg Pro Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg 
            180                 185                 190         


Ala Asn His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu 
        195                 200                 205             


Val Asn Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu 
    210                 215                 220                 


Asp Val Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu 
225                 230                 235                 240 


His Ala Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile 
                245                 250                 255     


Ser Pro Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly 
            260                 265                 270         


Gln Phe Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys 
        275                 280                 285             


Pro Asn Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala 
    290                 295                 300                 


Gln Arg Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu 
305                 310                 315                 320 


Pro Asn Met Thr Gln Gly Phe Trp Glu Asn Ser Met Leu Thr Asp Pro 
                325                 330                 335     


Gly Asn Val Gln Lys Ala Val Cys His Pro Thr Ala Trp Asp Leu Gly 
            340                 345                 350         


Lys Gly Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp 
        355                 360                 365             


Phe Leu Thr Ala His His Glu Met Gly His Ile Gln Tyr Asp Met Ala 
    370                 375                 380                 


Tyr Ala Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe 
385                 390                 395                 400 


His Glu Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys 
                405                 410                 415     


His Leu Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn 
            420                 425                 430         


Glu Thr Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly 
        435                 440                 445             


Thr Leu Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe 
    450                 455                 460                 


Lys Gly Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met 
465                 470                 475                 480 


Lys Arg Glu Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr 
                485                 490                 495     


Tyr Cys Asp Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe 
            500                 505                 510         


Ile Arg Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala 
        515                 520                 525             


Leu Cys Gln Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile 
    530                 535                 540                 


Ser Asn Ser Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu 
545                 550                 555                 560 


Gly Lys Ser Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala 
                565                 570                 575     


Lys Asn Met Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe 
            580                 585                 590         


Thr Trp Leu Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr 
        595                 600                 605             


Asp Trp Ser Pro Tyr Ala Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
    610                 615                 620                 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
625                 630                 635                 640 


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
                645                 650                 655     


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
            660                 665                 670         


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
        675                 680                 685             


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
    690                 695                 700                 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
705                 710                 715                 720 


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
                725                 730                 735     


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
            740                 745                 750         


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
        755                 760                 765             


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
    770                 775                 780                 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
785                 790                 795                 800 


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
                805                 810                 815     


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
            820                 825                 830         


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        835                 840     


<210>  236
<211>  865
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ACE2-Fc IgA Hybrid Protein


<220>
<221>  misc_feature
<222>  (1)..(776)
<223>  ACE2 Portion

<220>
<221>  misc_feature
<222>  (777)..(865)
<223>  IgA Fc Portion

<400>  236

Met Ser Ser Ser Ser Trp Leu Leu Leu Ser Leu Val Ala Val Thr Ala 
1               5                   10                  15      


Ala Gln Ser Thr Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Lys Phe 
            20                  25                  30          


Asn His Glu Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ser Trp 
        35                  40                  45              


Asn Tyr Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn 
    50                  55                  60                  


Ala Gly Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Leu Ala 
65                  70                  75                  80  


Gln Met Tyr Pro Leu Gln Glu Ile Gln Asn Leu Thr Val Lys Leu Gln 
                85                  90                  95      


Leu Gln Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys 
            100                 105                 110         


Ser Lys Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser 
        115                 120                 125             


Thr Gly Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu 
    130                 135                 140                 


Glu Pro Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu 
145                 150                 155                 160 


Arg Leu Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu 
                165                 170                 175     


Arg Pro Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg 
            180                 185                 190         


Ala Asn His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu 
        195                 200                 205             


Val Asn Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu 
    210                 215                 220                 


Asp Val Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu 
225                 230                 235                 240 


His Ala Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile 
                245                 250                 255     


Ser Pro Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly 
            260                 265                 270         


Arg Phe Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys 
        275                 280                 285             


Pro Asn Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala 
    290                 295                 300                 


Gln Arg Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu 
305                 310                 315                 320 


Pro Asn Met Thr Gln Gly Phe Trp Glu Asn Ser Met Leu Thr Asp Pro 
                325                 330                 335     


Gly Asn Val Gln Lys Ala Val Cys His Pro Thr Ala Trp Asp Leu Gly 
            340                 345                 350         


Lys Gly Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp 
        355                 360                 365             


Phe Leu Thr Ala His His Glu Met Gly His Ile Gln Tyr Asp Met Ala 
    370                 375                 380                 


Tyr Ala Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe 
385                 390                 395                 400 


His Glu Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys 
                405                 410                 415     


His Leu Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn 
            420                 425                 430         


Glu Thr Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly 
        435                 440                 445             


Thr Leu Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe 
    450                 455                 460                 


Lys Gly Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met 
465                 470                 475                 480 


Lys Arg Glu Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr 
                485                 490                 495     


Tyr Cys Asp Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe 
            500                 505                 510         


Ile Arg Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala 
        515                 520                 525             


Leu Cys Gln Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile 
    530                 535                 540                 


Ser Asn Ser Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu 
545                 550                 555                 560 


Gly Lys Ser Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala 
                565                 570                 575     


Lys Asn Met Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe 
            580                 585                 590         


Thr Trp Leu Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr 
        595                 600                 605             


Asp Trp Ser Pro Tyr Ala Asp Pro Ser Thr Pro Pro Thr Pro Ser Pro 
    610                 615                 620                 


Ser Thr Pro Pro Thr Pro Ser Pro Ser Cys Cys His Pro Arg Leu Ser 
625                 630                 635                 640 


Leu His Arg Pro Ala Leu Glu Asp Leu Leu Leu Gly Ser Glu Ala Asn 
                645                 650                 655     


Leu Thr Cys Thr Leu Thr Gly Leu Arg Asp Ala Ser Gly Val Thr Phe 
            660                 665                 670         


Thr Trp Thr Pro Ser Ser Gly Lys Ser Ala Val Gln Gly Pro Pro Glu 
        675                 680                 685             


Arg Asp Leu Cys Gly Cys Tyr Ser Val Ser Ser Val Leu Pro Gly Cys 
    690                 695                 700                 


Ala Glu Pro Trp Asn His Gly Lys Thr Phe Thr Cys Thr Ala Ala Tyr 
705                 710                 715                 720 


Pro Glu Ser Lys Thr Pro Leu Thr Ala Thr Leu Ser Lys Ser Gly Asn 
                725                 730                 735     


Thr Phe Arg Pro Glu Val His Leu Leu Pro Pro Pro Ser Glu Glu Leu 
            740                 745                 750         


Ala Leu Asn Glu Leu Val Thr Leu Thr Cys Leu Ala Arg Gly Phe Ser 
        755                 760                 765             


Pro Lys Asp Val Leu Val Arg Trp Leu Gln Gly Ser Gln Glu Leu Pro 
    770                 775                 780                 


Arg Glu Lys Tyr Leu Thr Trp Ala Ser Arg Gln Glu Pro Ser Gln Gly 
785                 790                 795                 800 


Thr Thr Thr Phe Ala Val Thr Ser Ile Leu Arg Val Ala Ala Glu Asp 
                805                 810                 815     


Trp Lys Lys Gly Asp Thr Phe Ser Cys Met Val Gly His Glu Ala Leu 
            820                 825                 830         


Pro Leu Ala Phe Thr Gln Lys Thr Ile Asp Arg Leu Ala Gly Lys Pro 
        835                 840                 845             


Thr His Val Asn Val Ser Val Val Met Ala Glu Val Asp Gly Thr Cys 
    850                 855                 860                 


Tyr 
865 


<210>  237
<211>  865
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ACE2-Fc IgA R273Q Hybrid Protein


<220>
<221>  misc_feature
<222>  (1)..(776)
<223>  ACE2 Portion with R273Q mutation

<220>
<221>  misc_feature
<222>  (777)..(865)
<223>  IgA Fc Portion

<400>  237

Met Ser Ser Ser Ser Trp Leu Leu Leu Ser Leu Val Ala Val Thr Ala 
1               5                   10                  15      


Ala Gln Ser Thr Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Lys Phe 
            20                  25                  30          


Asn His Glu Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ser Trp 
        35                  40                  45              


Asn Tyr Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn 
    50                  55                  60                  


Ala Gly Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Leu Ala 
65                  70                  75                  80  


Gln Met Tyr Pro Leu Gln Glu Ile Gln Asn Leu Thr Val Lys Leu Gln 
                85                  90                  95      


Leu Gln Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys 
            100                 105                 110         


Ser Lys Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser 
        115                 120                 125             


Thr Gly Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu 
    130                 135                 140                 


Glu Pro Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu 
145                 150                 155                 160 


Arg Leu Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu 
                165                 170                 175     


Arg Pro Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg 
            180                 185                 190         


Ala Asn His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu 
        195                 200                 205             


Val Asn Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu 
    210                 215                 220                 


Asp Val Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu 
225                 230                 235                 240 


His Ala Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile 
                245                 250                 255     


Ser Pro Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly 
            260                 265                 270         


Gln Phe Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys 
        275                 280                 285             


Pro Asn Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala 
    290                 295                 300                 


Gln Arg Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu 
305                 310                 315                 320 


Pro Asn Met Thr Gln Gly Phe Trp Glu Asn Ser Met Leu Thr Asp Pro 
                325                 330                 335     


Gly Asn Val Gln Lys Ala Val Cys His Pro Thr Ala Trp Asp Leu Gly 
            340                 345                 350         


Lys Gly Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp 
        355                 360                 365             


Phe Leu Thr Ala His His Glu Met Gly His Ile Gln Tyr Asp Met Ala 
    370                 375                 380                 


Tyr Ala Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe 
385                 390                 395                 400 


His Glu Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys 
                405                 410                 415     


His Leu Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn 
            420                 425                 430         


Glu Thr Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly 
        435                 440                 445             


Thr Leu Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe 
    450                 455                 460                 


Lys Gly Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met 
465                 470                 475                 480 


Lys Arg Glu Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr 
                485                 490                 495     


Tyr Cys Asp Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe 
            500                 505                 510         


Ile Arg Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala 
        515                 520                 525             


Leu Cys Gln Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile 
    530                 535                 540                 


Ser Asn Ser Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu 
545                 550                 555                 560 


Gly Lys Ser Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala 
                565                 570                 575     


Lys Asn Met Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe 
            580                 585                 590         


Thr Trp Leu Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr 
        595                 600                 605             


Asp Trp Ser Pro Tyr Ala Asp Pro Ser Thr Pro Pro Thr Pro Ser Pro 
    610                 615                 620                 


Ser Thr Pro Pro Thr Pro Ser Pro Ser Cys Cys His Pro Arg Leu Ser 
625                 630                 635                 640 


Leu His Arg Pro Ala Leu Glu Asp Leu Leu Leu Gly Ser Glu Ala Asn 
                645                 650                 655     


Leu Thr Cys Thr Leu Thr Gly Leu Arg Asp Ala Ser Gly Val Thr Phe 
            660                 665                 670         


Thr Trp Thr Pro Ser Ser Gly Lys Ser Ala Val Gln Gly Pro Pro Glu 
        675                 680                 685             


Arg Asp Leu Cys Gly Cys Tyr Ser Val Ser Ser Val Leu Pro Gly Cys 
    690                 695                 700                 


Ala Glu Pro Trp Asn His Gly Lys Thr Phe Thr Cys Thr Ala Ala Tyr 
705                 710                 715                 720 


Pro Glu Ser Lys Thr Pro Leu Thr Ala Thr Leu Ser Lys Ser Gly Asn 
                725                 730                 735     


Thr Phe Arg Pro Glu Val His Leu Leu Pro Pro Pro Ser Glu Glu Leu 
            740                 745                 750         


Ala Leu Asn Glu Leu Val Thr Leu Thr Cys Leu Ala Arg Gly Phe Ser 
        755                 760                 765             


Pro Lys Asp Val Leu Val Arg Trp Leu Gln Gly Ser Gln Glu Leu Pro 
    770                 775                 780                 


Arg Glu Lys Tyr Leu Thr Trp Ala Ser Arg Gln Glu Pro Ser Gln Gly 
785                 790                 795                 800 


Thr Thr Thr Phe Ala Val Thr Ser Ile Leu Arg Val Ala Ala Glu Asp 
                805                 810                 815     


Trp Lys Lys Gly Asp Thr Phe Ser Cys Met Val Gly His Glu Ala Leu 
            820                 825                 830         


Pro Leu Ala Phe Thr Gln Lys Thr Ile Asp Arg Leu Ala Gly Lys Pro 
        835                 840                 845             


Thr His Val Asn Val Ser Val Val Met Ala Glu Val Asp Gly Thr Cys 
    850                 855                 860                 


Tyr 
865 


