                         SEQUENCE LISTING

<110>  University of Central Florida Research Foundation, Inc.
 
<120>  DELIVERY OF GENE EXPRESSION MODULATING AGENTS FOR THERAPY AGAINST

<130>  10669-303PC0

<140>  PCT/US21/21674
<141>  2021-03-10

<150>  62/987,483
<151>  2020-03-10

<160>  6     

<170>  PatentIn version 3.5

<210>  1
<211>  1628
<212>  DNA
<213>  Homo sapiens

<400>  1
tttttcctcc tcttcctcta tactaacatg agtgtggatc cagcttgtcc ccaaagcttg       60

ccttgctttg aagaatccga ctgtaaagaa tcttcaccta tgcctgtgat ttgtgggcct      120

gaagaaaact atccatcctt gcaaatgtct tctgctgaga tgcctcacac agagactgtc      180

tctcctcttc cttcctccat ggatctgctt attcaggaca gccctgattc ttccaccagt      240

cccaaaggca aacaacccac ttctgcagag aatagtgtcg caaaaaagga agacaaggtc      300

ccggtcaaga aacagaagac cagaactgtg ttctcttcca cccagctgtg tgtactcaat      360

gatagatttc agagacagaa atacctcagc ctccagcaga tgcaagaact ctccaacatc      420

ctgaacctca gctacaaaca ggtgaagacc tggttccaga accagagaat gaaatctaag      480

aggtggcaga aaaacaactg gccgaagaat agcaatggtg tgacgcagaa ggcctcagca      540

cctacctacc ccagcctcta ctcttcctac caccagggat gcctggtgaa cccgactggg      600

aaccttccaa tgtggagcaa ccagacctgg aacaattcaa cctggagcaa ccagacccag      660

aacatccagt cctggagcaa ccactcctgg aacactcaga cctggtgcac ccaatcctgg      720

aacaatcagg cctggaacag tcccttctat aactgtggag aggaatctct gcagtcctgc      780

atgcacttcc agccaaattc tcctgccagt gacttggagg ctgccttgga agctgctggg      840

gaaggcctta atgtaataca gcagaccact aggtatttta gtactccaca aaccatggat      900

ttattcctaa actactccat gaacatgcaa cctgaagacg tgtgaagatg agtgaaactg      960

atattactca atttcagtct ggacactggc tgaatccttc ctctcccctc ctcccatccc     1020

tcataggatt tttcttgttt ggaaaccacg tgttctggtt tccatgatgc ctatccagtc     1080

aatctcatgg agggtggagt atggttggag cctaatcagc gaggtttctt tttttttttt     1140

tcctattgga tcttcctgga gaaaatactt tttttttttt ttttgagacg gagtcttgct     1200

ctgtcgccca ggctggagtg cagtggcgcg gtcttggctc actgcaagct ccgcctcccg     1260

ggttcacgcc attctcctgc ctcagcctcc cgagcagctg ggactacagg cgcccgccac     1320

ctcgcccggc taatattttg tatttttagt agagacaggg tttcactgtg ttagccagga     1380

tggtctcgat ctcctgacct tgtgatccgc ccgcctcggc ctccctaaca gctgggatta     1440

caggcgtgag ccaccgcgcc ctgcctagaa aagacatttt aataaccttg gctgctaagg     1500

acaacattga tagaagccgt ctctggctat agataagtag atctaatact agtttggata     1560

tctttagggt ttagaatcta acctcaagaa taagaaatac aagtacgaat tggtgatgaa     1620

gatgtatt                                                              1628


<210>  2
<211>  305
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ser Val Asp Pro Ala Cys Pro Gln Ser Leu Pro Cys Phe Glu Ala 
1               5                   10                  15      


Ser Asp Cys Lys Glu Ser Ser Pro Met Pro Val Ile Cys Gly Pro Glu 
            20                  25                  30          


Glu Asn Tyr Pro Ser Leu Gln Met Ser Ser Ala Glu Met Pro His Thr 
        35                  40                  45              


Glu Thr Val Ser Pro Leu Pro Ser Ser Met Asp Leu Leu Ile Gln Asp 
    50                  55                  60                  


Ser Pro Asp Ser Ser Thr Ser Pro Lys Gly Lys Gln Pro Thr Ser Ala 
65                  70                  75                  80  


Glu Lys Ser Val Ala Lys Lys Glu Asp Lys Val Pro Val Lys Lys Gln 
                85                  90                  95      


Lys Thr Arg Thr Val Phe Ser Ser Thr Gln Leu Cys Val Leu Asn Asp 
            100                 105                 110         


Arg Phe Gln Arg Gln Lys Tyr Leu Ser Leu Gln Gln Met Gln Glu Leu 
        115                 120                 125             


Ser Asn Ile Leu Asn Leu Ser Tyr Lys Gln Val Lys Thr Trp Phe Gln 
    130                 135                 140                 


Asn Gln Arg Met Lys Ser Lys Arg Trp Gln Lys Asn Asn Trp Pro Lys 
145                 150                 155                 160 


Asn Ser Asn Gly Val Thr Gln Lys Ala Ser Ala Pro Thr Tyr Pro Ser 
                165                 170                 175     


Leu Tyr Ser Ser Tyr His Gln Gly Cys Leu Val Asn Pro Thr Gly Asn 
            180                 185                 190         


Leu Pro Met Trp Ser Asn Gln Thr Trp Asn Asn Ser Thr Trp Ser Asn 
        195                 200                 205             


Gln Thr Gln Asn Ile Gln Ser Trp Ser Asn His Ser Trp Asn Thr Gln 
    210                 215                 220                 


Thr Trp Cys Thr Gln Ser Trp Asn Asn Gln Ala Trp Asn Ser Pro Phe 
225                 230                 235                 240 


Tyr Asn Cys Gly Glu Glu Ser Leu Gln Ser Cys Met Gln Phe Gln Pro 
                245                 250                 255     


Asn Ser Pro Ala Ser Asp Leu Glu Ala Ala Leu Glu Ala Ala Gly Glu 
            260                 265                 270         


Gly Leu Asn Val Ile Gln Gln Thr Thr Arg Tyr Phe Ser Thr Pro Gln 
        275                 280                 285             


Thr Met Asp Leu Phe Leu Asn Tyr Ser Met Asn Met Gln Pro Glu Asp 
    290                 295                 300                 


Val 
305 


<210>  3
<211>  1409
<212>  DNA
<213>  Homo sapiens

<400>  3
gagtagtccc ttcgcaagcc ctcatttcac caggcccccg gcttggggcg ccttccttcc       60

ccatggcggg acacctggct tcggatttcg ccttctcgcc ccctccaggt ggtggaggtg      120

atgggccagg ggggccggag ccgggctggg ttgatcctcg gacctggcta agcttccaag      180

gccctcctgg agggccagga atcgggccgg gggttgggcc aggctctgag gtgtggggga      240

ttcccccatg ccccccgccg tatgagttct gtggggggat ggcgtactgt gggccccagg      300

ttggagtggg gctagtgccc caaggcggct tggagacctc tcagcctgag ggcgaagcag      360

gagtcggggt ggagagcaac tccgatgggg cctccccgga gccctgcacc gtcacccctg      420

gtgccgtgaa gctggagaag gagaagctgg agcaaaaccc ggaggagtcc caggacatca      480

aagctctgca gaaagaactc gagcaatttg ccaagctcct gaagcagaag aggatcaccc      540

tgggatatac acaggccgat gtggggctca ccctgggggt tctatttggg aaggtattca      600

gccaaacgac catctgccgc tttgaggctc tgcagcttag cttcaagaac atgtgtaagc      660

tgcggccctt gctgcagaag tgggtggagg aagctgacaa caatgaaaat cttcaggaga      720

tatgcaaagc agaaaccctc gtgcaggccc gaaagagaaa gcgaaccagt atcgagaacc      780

gagtgagagg caacctggag aatttgttcc tgcagtgccc gaaacccaca ctgcagcaga      840

tcagccacat cgcccagcag cttgggctcg agaaggatgt ggtccgagtg tggttctgta      900

accggcgcca gaagggcaag cgatcaagca gcgactatgc acaacgagag gattttgagg      960

ctgctgggtc tcctttctca gggggaccag tgtcctttcc tctggcccca gggccccatt     1020

ttggtacccc aggctatggg agccctcact tcactgcact gtactcctcg gtccctttcc     1080

ctgaggggga agcctttccc cctgtctccg tcaccactct gggctctccc atgcattcaa     1140

actgaggtgc ctgcccttct aggaatgggg gacaggggga ggggaggagc tagggaaaga     1200

aaacctggag tttgtgccag ggtttttggg attaagttct tcattcacta aggaaggaat     1260

tgggaacaca aagggtgggg gcaggggagt ttggggcaac tggttggagg gaaggtgaag     1320

ttcaatgatg ctcttgattt taatcccaca tcatgtatca cttttttctt aaataaagaa     1380

gcctgggaca cagtagatag acacactta                                       1409


<210>  4
<211>  360
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Ala Gly His Leu Ala Ser Asp Phe Ala Phe Ser Pro Pro Pro Gly 
1               5                   10                  15      


Gly Gly Gly Asp Gly Pro Gly Gly Pro Glu Pro Gly Trp Val Asp Pro 
            20                  25                  30          


Arg Thr Trp Leu Ser Phe Gln Gly Pro Pro Gly Gly Pro Gly Ile Gly 
        35                  40                  45              


Pro Gly Val Gly Pro Gly Ser Glu Val Trp Gly Ile Pro Pro Cys Pro 
    50                  55                  60                  


Pro Pro Tyr Glu Phe Cys Gly Gly Met Ala Tyr Cys Gly Pro Gln Val 
65                  70                  75                  80  


Gly Val Gly Leu Val Pro Gln Gly Gly Leu Glu Thr Ser Gln Pro Glu 
                85                  90                  95      


Gly Glu Ala Gly Val Gly Val Glu Ser Asn Ser Asp Gly Ala Ser Pro 
            100                 105                 110         


Glu Pro Cys Thr Val Thr Pro Gly Ala Val Lys Leu Glu Lys Glu Lys 
        115                 120                 125             


Leu Glu Gln Asn Pro Glu Glu Ser Gln Asp Ile Lys Ala Leu Gln Lys 
    130                 135                 140                 


Glu Leu Glu Gln Phe Ala Lys Leu Leu Lys Gln Lys Arg Ile Thr Leu 
145                 150                 155                 160 


Gly Tyr Thr Gln Ala Asp Val Gly Leu Thr Leu Gly Val Leu Phe Gly 
                165                 170                 175     


Lys Val Phe Ser Gln Thr Thr Ile Cys Arg Phe Glu Ala Leu Gln Leu 
            180                 185                 190         


Ser Phe Lys Asn Met Cys Lys Leu Arg Pro Leu Leu Gln Lys Trp Val 
        195                 200                 205             


Glu Glu Ala Asp Asn Asn Glu Asn Leu Gln Glu Ile Cys Lys Ala Glu 
    210                 215                 220                 


Thr Leu Val Gln Ala Arg Lys Arg Lys Arg Thr Ser Ile Glu Asn Arg 
225                 230                 235                 240 


Val Arg Gly Asn Leu Glu Asn Leu Phe Leu Gln Cys Pro Lys Pro Thr 
                245                 250                 255     


Leu Gln Gln Ile Ser His Ile Ala Gln Gln Leu Gly Leu Glu Lys Asp 
            260                 265                 270         


Val Val Arg Val Trp Phe Cys Asn Arg Arg Gln Lys Gly Lys Arg Ser 
        275                 280                 285             


Ser Ser Asp Tyr Ala Gln Arg Glu Asp Phe Glu Ala Ala Gly Ser Pro 
    290                 295                 300                 


Phe Ser Gly Gly Pro Val Ser Phe Pro Leu Ala Pro Gly Pro His Phe 
305                 310                 315                 320 


Gly Thr Pro Gly Tyr Gly Ser Pro His Phe Thr Ala Leu Tyr Ser Ser 
                325                 330                 335     


Val Pro Phe Pro Glu Gly Glu Ala Phe Pro Pro Val Ser Val Thr Thr 
            340                 345                 350         


Leu Gly Ser Pro Met His Ser Asn 
        355                 360 


<210>  5
<211>  1273
<212>  PRT
<213>  Sars-CoV-2

<400>  5

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
                245                 250                 255     


Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270         


Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285             


Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                 


Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
305                 310                 315                 320 


Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 
                325                 330                 335     


Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 
            340                 345                 350         


Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
        355                 360                 365             


Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
    370                 375                 380                 


Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
385                 390                 395                 400 


Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
                405                 410                 415     


Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
            420                 425                 430         


Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
        435                 440                 445             


Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
    450                 455                 460                 


Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
465                 470                 475                 480 


Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
                485                 490                 495     


Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
            500                 505                 510         


Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
        515                 520                 525             


Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
    530                 535                 540                 


Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
545                 550                 555                 560 


Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 
                565                 570                 575     


Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 
            580                 585                 590         


Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 
        595                 600                 605             


Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile 
    610                 615                 620                 


His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 
625                 630                 635                 640 


Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val 
                645                 650                 655     


Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 
            660                 665                 670         


Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala 
        675                 680                 685             


Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser 
    690                 695                 700                 


Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile 
705                 710                 715                 720 


Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 
                725                 730                 735     


Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu 
            740                 745                 750         


Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr 
        755                 760                 765             


Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln 
    770                 775                 780                 


Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe 
785                 790                 795                 800 


Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser 
                805                 810                 815     


Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly 
            820                 825                 830         


Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp 
        835                 840                 845             


Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu 
    850                 855                 860                 


Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly 
865                 870                 875                 880 


Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile 
                885                 890                 895     


Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr 
            900                 905                 910         


Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn 
        915                 920                 925             


Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala 
    930                 935                 940                 


Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn 
945                 950                 955                 960 


Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val 
                965                 970                 975     


Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln 
            980                 985                 990         


Ile Asp Arg Leu Ile Thr Gly Arg  Leu Gln Ser Leu Gln  Thr Tyr Val 
        995                 1000                 1005             


Thr Gln  Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
    1010                 1015                 1020             


Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1025                 1030                 1035             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1040                 1045                 1050             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1055                 1060                 1065             


Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1070                 1075                 1080             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1085                 1090                 1095             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1100                 1105                 1110             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1115                 1120                 1125             


Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro 
    1130                 1135                 1140             


Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Tyr  Phe Lys Asn 
    1145                 1150                 1155             


His Thr  Ser Pro Asp Val Asp  Leu Gly Asp Ile Ser  Gly Ile Asn 
    1160                 1165                 1170             


Ala Ser  Val Val Asn Ile Gln  Lys Glu Ile Asp Arg  Leu Asn Glu 
    1175                 1180                 1185             


Val Ala  Lys Asn Leu Asn Glu  Ser Leu Ile Asp Leu  Gln Glu Leu 
    1190                 1195                 1200             


Gly Lys  Tyr Glu Gln Tyr Ile  Lys Trp Pro Trp Tyr  Ile Trp Leu 
    1205                 1210                 1215             


Gly Phe  Ile Ala Gly Leu Ile  Ala Ile Val Met Val  Thr Ile Met 
    1220                 1225                 1230             


Leu Cys  Cys Met Thr Ser Cys  Cys Ser Cys Leu Lys  Gly Cys Cys 
    1235                 1240                 1245             


Ser Cys  Gly Ser Cys Cys Lys  Phe Asp Glu Asp Asp  Ser Glu Pro 
    1250                 1255                 1260             


Val Leu  Lys Gly Val Lys Leu  His Tyr Thr 
    1265                 1270             


<210>  6
<211>  7683
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  shRNA vector

<400>  6
aatgtagtct tatgcaatac tcttgtagtc ttgcaacatg gtaacgatga gttagcaaca       60

tgccttacaa ggagagaaaa agcaccgtgc atgccgattg gtggaagtaa ggtggtacga      120

tcgtgcctta ttaggaaggc aacagacggg tctgacatgg attggacgaa ccactgaatt      180

gccgcattgc agagatattg tatttaagtg cctagctcga tacataaacg ggtctctctg      240

gttagaccag atctgagcct gggagctctc tggctaacta gggaacccac tgcttaagcc      300

tcaataaagc ttgccttgag tgcttcaagt agtgtgtgcc cgtctgttgt gtgactctgg      360

taactagaga tccctcagac ccttttagtc agtgtggaaa atctctagca gtggcgcccg      420

aacagggact tgaaagcgaa agggaaacca gaggagctct ctcgacgcag gactcggctt      480

gctgaagcgc gcacggcaag aggcgagggg cggcgactgg tgagtacgcc aaaaattttg      540

actagcggag gctagaagga gagagatggg tgcgagagcg tcagtattaa gcgggggaga      600

attagatcgc gatgggaaaa aattcggtta aggccagggg gaaagaaaaa atataaatta      660

aaacatatag tatgggcaag cagggagcta gaacgattcg cagttaatcc tggcctgtta      720

gaaacatcag aaggctgtag acaaatactg ggacagctac aaccatccct tcagacagga      780

tcagaagaac ttagatcatt atataataca gtagcaaccc tctattgtgt gcatcaaagg      840

atagagataa aagacaccaa ggaagcttta gacaagatag aggaagagca aaacaaaagt      900

aagaccaccg cacagcaagc ggccgctgat cttcagacct ggaggaggag atatgaggga      960

caattggaga agtgaattat ataaatataa agtagtaaaa attgaaccat taggagtagc     1020

acccaccaag gcaaagagaa gagtggtgca gagagaaaaa agagcagtgg gaataggagc     1080

tttgttcctt gggttcttgg gagcagcagg aagcactatg ggcgcagcgt caatgacgct     1140

gacggtacag gccagacaat tattgtctgg tatagtgcag cagcagaaca atttgctgag     1200

ggctattgag gcgcaacagc atctgttgca actcacagtc tggggcatca agcagctcca     1260

ggcaagaatc ctggctgtgg aaagatacct aaaggatcaa cagctcctgg ggatttgggg     1320

ttgctctgga aaactcattt gcaccactgc tgtgccttgg aatgctagtt ggagtaataa     1380

atctctggaa cagatttgga atcacacgac ctggatggag tgggacagag aaattaacaa     1440

ttacacaagc ttaatacact ccttaattga agaatcgcaa aaccagcaag aaaagaatga     1500

acaagaatta ttggaattag ataaatgggc aagtttgtgg aattggttta acataacaaa     1560

ttggctgtgg tatataaaat tattcataat gatagtagga ggcttggtag gtttaagaat     1620

agtttttgct gtactttcta tagtgaatag agttaggcag ggatattcac cattatcgtt     1680

tcagacccac ctcccaaccc cgaggggacc cgacaggccc gaaggaatag aagaagaagg     1740

tggagagaga gacagagaca gatccattcg attagtgaac ggatctcgac ggtatcgcta     1800

gcttttaaaa gaaaaggggg gattgggggg tacagtgcag gggaaagaat agtagacata     1860

atagcaacag acatacaaac taaagaatta caaaaacaaa ttacaaaaat tcaaaatttt     1920

actagtgagg gcctatttcc catgattcct tcatatttgc atatacgata caaggctgtt     1980

agagagataa ttggaattaa tttgactgta aacacaaaga tattagtaca aaatacgtga     2040

cgtagaaagt aataatttct tgggtagttt gcagttttaa aattatgttt taaaatggac     2100

tatcatatgc ttaccgtaac ttgaaagtat ttcgatttct tggctttata tatcttgtgg     2160

aaaggacgaa acaccggttt ctcaactaaa cttcctctcg agaggaagtt tagttgagaa     2220

atttttgaat tccaactttg tatagaaaag ttggggttgc gccttttcca aggcagccct     2280

gggtttgcgc agggacgcgg ctgctctggg cgtggttccg ggaaacgcag cggcgccgac     2340

cctgggtctc gcacattctt cacgtccgtt cgcagcgtca cccggatctt cgccgctacc     2400

cttgtgggcc ccccggcgac gcttcctgct ccgcccctaa gtcgggaagg ttccttgcgg     2460

ttcgcggcgt gccggacgtg acaaacggaa gccgcacgtc tcactagtac cctcgcagac     2520

ggacagcgcc agggagcaat ggcagcgcgc cgaccgcgat gggctgtggc caatagcggc     2580

tgctcagcag ggcgcgccga gagcagcggc cgggaagggg cggtgcggga ggcggggtgt     2640

ggggcggtag tgtgggccct gttcctgccc gcgcggtgtt ccgcattctg caagcctccg     2700

gagcgcacgt cggcagtcgg ctccctcgtt gaccgaatca ccgacctctc tccccaggca     2760

agtttgtaca aaaaagcagg ctgccaccat ggtgagcaag ggcgaggagc tgttcaccgg     2820

ggtggtgccc atcctggtcg agctggacgg cgacgtaaac ggccacaagt tcagcgtgtc     2880

cggcgagggc gagggcgatg ccacctacgg caagctgacc ctgaagttca tctgcaccac     2940

cggcaagctg cccgtgccct ggcccaccct cgtgaccacc ctgacctacg gcgtgcagtg     3000

cttcagccgc taccccgacc acatgaagca gcacgacttc ttcaagtccg ccatgcccga     3060

aggctacgtc caggagcgca ccatcttctt caaggacgac ggcaactaca agacccgcgc     3120

cgaggtgaag ttcgagggcg acaccctggt gaaccgcatc gagctgaagg gcatcgactt     3180

caaggaggac ggcaacatcc tggggcacaa gctggagtac aactacaaca gccacaacgt     3240

ctatatcatg gccgacaagc agaagaacgg catcaaggtg aacttcaaga tccgccacaa     3300

catcgaggac ggcagcgtgc agctcgccga ccactaccag cagaacaccc ccatcggcga     3360

cggccccgtg ctgctgcccg acaaccacta cctgagcacc cagtccgccc tgagcaaaga     3420

ccccaacgag aagcgcgatc acatggtcct gctggagttc gtgaccgccg ccgggatcac     3480

tctcggcatg gacgagctgt acaagtaaac ccagctttct tgtacaaagt ggtggtaccc     3540

gataatcaac ctctggatta caaaatttgt gaaagattga ctggtattct taactatgtt     3600

gctcctttta cgctatgtgg atacgctgct ttaatgcctt tgtatcatgc tattgcttcc     3660

cgtatggctt tcattttctc ctccttgtat aaatcctggt tgctgtctct ttatgaggag     3720

ttgtggcccg ttgtcaggca acgtggcgtg gtgtgcactg tgtttgctga cgcaaccccc     3780

actggttggg gcattgccac cacctgtcag ctcctttccg ggactttcgc tttccccctc     3840

cctattgcca cggcggaact catcgccgcc tgccttgccc gctgctggac aggggctcgg     3900

ctgttgggca ctgacaattc cgtggtgttg tcggggaagc tgacgtcctt tccatggctg     3960

ctcgcctgtg ttgccacctg gattctgcgc gggacgtcct tctgctacgt cccttcggcc     4020

ctcaatccag cggaccttcc ttcccgcggc ctgctgccgg ctctgcggcc tcttccgcgt     4080

cttcgccttc gccctcagac gagtcggatc tccctttggg ccgcctcccc gcatcggctt     4140

taagaccaat gacttacaag gcagctgtag atcttagcca ctttttaaaa gaaaaggggg     4200

gactggaagg gctaattcac tcccaacgaa gacaagatct gctttttgct tgtactgggt     4260

ctctctggtt agaccagatc tgagcctggg agctctctgg ctaactaggg aacccactgc     4320

ttaagcctca ataaagcttg ccttgagtgc ttcaagtagt gtgtgcccgt ctgttgtgtg     4380

actctggtaa ctagagatcc ctcagaccct tttagtcagt gtggaaaatc tctagcagta     4440

gtagttcatg tcatcttatt attcagtatt tataacttgc aaagaaatga atatcagaga     4500

gtgagaggaa cttgtttatt gcagcttata atggttacaa ataaagcaat agcatcacaa     4560

atttcacaaa taaagcattt ttttcactgc attctagttg tggtttgtcc aaactcatca     4620

atgtatctta tcatgtctgg ctctagctat cccgccccta actccgccca tcccgcccct     4680

aactccgccc agttccgccc attctccgcc ccatggctga ctaatttttt ttatttatgc     4740

agaggccgag gccgcctcgg cctctgagct attccagaag tagtgaggag gcttttttgg     4800

aggcctaggg acgtacccaa ttcgccctat agtgagtcgt attacgcgcg ctcactggcc     4860

gtcgttttac aacgtcgtga ctgggaaaac cctggcgtta cccaacttaa tcgccttgca     4920

gcacatcccc ctttcgccag ctggcgtaat agcgaagagg cccgcaccga tcgcccttcc     4980

caacagttgc gcagcctgaa tggcgaatgg gacgcgccct gtagcggcgc attaagcgcg     5040

gcgggtgtgg tggttacgcg cagcgtgacc gctacacttg ccagcgccct agcgcccgct     5100

cctttcgctt tcttcccttc ctttctcgcc acgttcgccg gctttccccg tcaagctcta     5160

aatcgggggc tccctttagg gttccgattt agtgctttac ggcacctcga ccccaaaaaa     5220

cttgattagg gtgatggttc acgtagtggg ccatcgccct gatagacggt ttttcgccct     5280

ttgacgttgg agtccacgtt ctttaatagt ggactcttgt tccaaactgg aacaacactc     5340

aaccctatct cggtctattc ttttgattta taagggattt tgccgatttc ggcctattgg     5400

ttaaaaaatg agctgattta acaaaaattt aacgcgaatt ttaacaaaat attaacgctt     5460

acaatttagg tggcactttt cggggaaatg tgcgcggaac ccctatttgt ttatttttct     5520

aaatacattc aaatatgtat ccgctcatga gacaataacc ctgataaatg cttcaataat     5580

attgaaaaag gaagagtatg agtattcaac atttccgtgt cgcccttatt cccttttttg     5640

cggcattttg ccttcctgtt tttgctcacc cagaaacgct ggtgaaagta aaagatgctg     5700

aagatcagtt gggtgcacga gtgggttaca tcgaactgga tctcaacagc ggtaagatcc     5760

ttgagagttt tcgccccgaa gaacgttttc caatgatgag cacttttaaa gttctgctat     5820

gtggcgcggt attatcccgt attgacgccg ggcaagagca actcggtcgc cgcatacact     5880

attctcagaa tgacttggtt gagtactcac cagtcacaga aaagcatctt acggatggca     5940

tgacagtaag agaattatgc agtgctgcca taaccatgag tgataacact gcggccaact     6000

tacttctgac aacgatcgga ggaccgaagg agctaaccgc ttttttgcac aacatggggg     6060

atcatgtaac tcgccttgat cgttgggaac cggagctgaa tgaagccata ccaaacgacg     6120

agcgtgacac cacgatgcct gtagcaatgg caacaacgtt gcgcaaacta ttaactggcg     6180

aactacttac tctagcttcc cggcaacaat taatagactg gatggaggcg gataaagttg     6240

caggaccact tctgcgctcg gcccttccgg ctggctggtt tattgctgat aaatctggag     6300

ccggtgagcg tgggtctcgc ggtatcattg cagcactggg gccagatggt aagccctccc     6360

gtatcgtagt tatctacacg acggggagtc aggcaactat ggatgaacga aatagacaga     6420

tcgctgagat aggtgcctca ctgattaagc attggtaact gtcagaccaa gtttactcat     6480

atatacttta gattgattta aaacttcatt tttaatttaa aaggatctag gtgaagatcc     6540

tttttgataa tctcatgacc aaaatccctt aacgtgagtt ttcgttccac tgagcgtcag     6600

accccgtaga aaagatcaaa ggatcttctt gagatccttt ttttctgcgc gtaatctgct     6660

gcttgcaaac aaaaaaacca ccgctaccag cggtggtttg tttgccggat caagagctac     6720

caactctttt tccgaaggta actggcttca gcagagcgca gataccaaat actgttcttc     6780

tagtgtagcc gtagttaggc caccacttca agaactctgt agcaccgcct acatacctcg     6840

ctctgctaat cctgttacca gtggctgctg ccagtggcga taagtcgtgt cttaccgggt     6900

tggactcaag acgatagtta ccggataagg cgcagcggtc gggctgaacg gggggttcgt     6960

gcacacagcc cagcttggag cgaacgacct acaccgaact gagataccta cagcgtgagc     7020

tatgagaaag cgccacgctt cccgaagaga gaaaggcgga caggtatccg gtaagcggca     7080

gggtcggaac aggagagcgc acgagggagc ttccaggggg aaacgcctgg tatctttata     7140

gtcctgtcgg gtttcgccac ctctgacttg agcgtcgatt tttgtgatgc tcgtcagggg     7200

ggcggagcct atggaaaaac gccagcaacg cggccttttt acggttcctg gccttttgct     7260

ggccttttgc tcacatgttc tttcctgcgt tatcccctga ttctgtggat aaccgtatta     7320

ccgcctttga gtgagctgat accgctcgcc gcagccgaac gaccgagcgc agcgagtcag     7380

tgagcgagga agcggaagag cgcccaatac gcaaaccgcc tctccccgcg cgttggccga     7440

ttcattaatg cagctggcac gacaggtttc ccgactggaa agcgggcagt gagcgcaacg     7500

caattaatgt gagttagctc actcattagg caccccaggc tttacacttt atgcttccgg     7560

ctcgtatgtt gtgtggaatt gtgagcggat aacaatttca cacaggaaac agctatgacc     7620

atgattacgc caagcgcgca attaaccctc actaaaggga acaaaagctg gagctgcaag     7680

ctt                                                                   7683


