                         SEQUENCE LISTING

<110>  RETINAL SOLUTIONS LLC
       Trese, Michael T
       Capone, Antonio  Jr.
       Drenser, Kimberly
 
<120>  NORRIN REGULATION OF PLASMALEMMA VESICLE-ASSOCIATED PROTEIN AND 
       USE TO TREAT MACULAR DEGENERATION

<130>  RETS-0110PCT

<140>  PCT/US2021/
<141>  2021-03-08

<150>   62/986,871
<151>  2020-03-09

<160>  21    

<170>  PatentIn version 3.5

<210>  1
<211>  133
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Arg Lys His Val Leu Ala Ala Ser Phe Ser Met Leu Ser Leu Leu 
1               5                   10                  15      


Val Ile Met Gly Asp Thr Asp Ser Lys Thr Asp Ser Ser Phe Ile Met 
            20                  25                  30          


Asp Ser Asp Pro Arg Arg Cys Met Arg His His Tyr Val Asp Ser Ile 
        35                  40                  45              


Ser His Pro Leu Tyr Lys Cys Ser Ser Lys Met Val Leu Leu Ala Arg 
    50                  55                  60                  


Cys Glu Gly His Cys Ser Gln Ala Ser Arg Ser Glu Pro Leu Val Ser 
65                  70                  75                  80  


Phe Ser Thr Val Leu Lys Gln Pro Phe Arg Ser Ser Cys His Cys Cys 
                85                  90                  95      


Arg Pro Gln Thr Ser Lys Leu Lys Ala Leu Arg Leu Arg Cys Ser Gly 
            100                 105                 110         


Gly Met Arg Leu Thr Ala Thr Tyr Arg Tyr Ile Leu Ser Cys His Cys 
        115                 120                 125             


Glu Glu Cys Asn Ser 
    130             


<210>  2
<211>  109
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  2

Lys Thr Asp Ser Ser Phe Ile Met Asp Ser Asp Pro Arg Arg Cys Met 
1               5                   10                  15      


Arg His His Tyr Val Asp Ser Ile Ser His Pro Leu Tyr Lys Cys Ser 
            20                  25                  30          


Ser Lys Met Val Leu Leu Ala Arg Cys Glu Gly His Cys Ser Gln Ala 
        35                  40                  45              


Ser Arg Ser Glu Pro Leu Val Ser Phe Ser Thr Val Leu Lys Gln Pro 
    50                  55                  60                  


Phe Arg Ser Ser Cys His Cys Cys Arg Pro Gln Thr Ser Lys Leu Lys 
65                  70                  75                  80  


Ala Leu Arg Leu Arg Cys Ser Gly Gly Met Arg Leu Thr Ala Thr Tyr 
                85                  90                  95      


Arg Tyr Ile Leu Ser Cys His Cys Glu Glu Cys Asn Ser 
            100                 105                 


<210>  3
<211>  133
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  3

Met Arg Lys His Val Leu Ala Ala Ser Phe Ser Met Leu Ser Leu Leu 
1               5                   10                  15      


Val Ile Met Gly Asp Thr Asp Ser Lys Thr Asp Ser Ser Phe Ile Met 
            20                  25                  30          


Asp Ser Asp Pro Arg Arg Cys Met Arg His His Tyr Val Asp Ser Ile 
        35                  40                  45              


Ser His Pro Leu Tyr Lys Cys Ser Ser Lys Met Val Leu Leu Ala Glu 
    50                  55                  60                  


Cys Glu Gly His Cys Ser Gln Ala Ser Arg Ser Glu Pro Leu Val Ser 
65                  70                  75                  80  


Phe Ser Thr Val Leu Lys Gln Pro Phe Arg Ser Ser Cys His Cys Cys 
                85                  90                  95      


Arg Pro Gln Thr Ser Lys Leu Lys Ala Leu Arg Leu Arg Cys Ser Gly 
            100                 105                 110         


Gly Met Arg Leu Thr Ala Thr Tyr Arg Tyr Ile Leu Ser Cys His Cys 
        115                 120                 125             


Glu Glu Cys Asn Ser 
    130             


<210>  4
<211>  133
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthethic

<400>  4

Met Arg Lys His Val Leu Ala Ala Ser Phe Ser Met Leu Ser Leu Leu 
1               5                   10                  15      


Val Ile Met Gly Asp Thr Asp Ser Lys Ala Asp Ser Ser Phe Ile Met 
            20                  25                  30          


Asp Ser Asp Pro Arg Arg Cys Met Arg His His Tyr Val Asp Ser Ile 
        35                  40                  45              


Ser His Pro Leu Tyr Lys Cys Ser Ser Lys Met Val Leu Leu Ala Arg 
    50                  55                  60                  


Cys Glu Gly His Cys Ser Gln Ala Ser Arg Ser Glu Pro Leu Val Ser 
65                  70                  75                  80  


Phe Ser Thr Val Leu Lys Gln Pro Phe Arg Ser Ser Cys His Cys Cys 
                85                  90                  95      


Arg Pro Gln Thr Ser Lys Leu Lys Ala Leu Arg Leu Arg Cys Ser Gly 
            100                 105                 110         


Gly Met Arg Leu Thr Ala Thr Tyr Arg Tyr Ile Leu Ser Cys His Cys 
        115                 120                 125             


Glu Glu Cys Asn Ser 
    130             


<210>  5
<211>  133
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  5

Met Arg Lys His Val Leu Ala Ala Ser Phe Ser Met Leu Ser Leu Leu 
1               5                   10                  15      


Val Ile Met Gly Asp Thr Asp Ser Lys Thr Asp Ala Ser Phe Ile Met 
            20                  25                  30          


Asp Ser Asp Pro Arg Arg Cys Met Arg His His Tyr Val Asp Ser Ile 
        35                  40                  45              


Ser His Pro Leu Tyr Lys Cys Ser Ser Lys Met Val Leu Leu Ala Arg 
    50                  55                  60                  


Cys Glu Gly His Cys Ser Gln Ala Ser Arg Ser Glu Pro Leu Val Ser 
65                  70                  75                  80  


Phe Ser Thr Val Leu Lys Gln Pro Phe Arg Ser Ser Cys His Cys Cys 
                85                  90                  95      


Arg Pro Gln Thr Ser Lys Leu Lys Ala Leu Arg Leu Arg Cys Ser Gly 
            100                 105                 110         


Gly Met Arg Leu Thr Ala Thr Tyr Arg Tyr Ile Leu Ser Cys His Cys 
        115                 120                 125             


Glu Glu Cys Asn Ser 
    130             


<210>  6
<211>  133
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  6

Met Arg Lys His Val Leu Ala Ala Ser Phe Ser Met Leu Ser Leu Leu 
1               5                   10                  15      


Val Ile Met Gly Asp Thr Asp Ser Lys Thr Asp Ser Ala Phe Ile Met 
            20                  25                  30          


Asp Ser Asp Pro Arg Arg Cys Met Arg His His Tyr Val Asp Ser Ile 
        35                  40                  45              


Ser His Pro Leu Tyr Lys Cys Ser Ser Lys Met Val Leu Leu Ala Arg 
    50                  55                  60                  


Cys Glu Gly His Cys Ser Gln Ala Ser Arg Ser Glu Pro Leu Val Ser 
65                  70                  75                  80  


Phe Ser Thr Val Leu Lys Gln Pro Phe Arg Ser Ser Cys His Cys Cys 
                85                  90                  95      


Arg Pro Gln Thr Ser Lys Leu Lys Ala Leu Arg Leu Arg Cys Ser Gly 
            100                 105                 110         


Gly Met Arg Leu Thr Ala Thr Tyr Arg Tyr Ile Leu Ser Cys His Cys 
        115                 120                 125             


Glu Glu Cys Asn Ser 
    130             


<210>  7
<211>  133
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  7

Met Arg Lys His Val Leu Ala Ala Ser Phe Ser Met Leu Ser Leu Leu 
1               5                   10                  15      


Val Ile Met Gly Asp Thr Asp Ser Lys Thr Asp Ser Ser Phe Ile Met 
            20                  25                  30          


Asp Ser Asp Ala Arg Arg Cys Met Arg His His Tyr Val Asp Ser Ile 
        35                  40                  45              


Ser His Pro Leu Tyr Lys Cys Ser Ser Lys Met Val Leu Leu Ala Arg 
    50                  55                  60                  


Cys Glu Gly His Cys Ser Gln Ala Ser Arg Ser Glu Pro Leu Val Ser 
65                  70                  75                  80  


Phe Ser Thr Val Leu Lys Gln Pro Phe Arg Ser Ser Cys His Cys Cys 
                85                  90                  95      


Arg Pro Gln Thr Ser Lys Leu Lys Ala Leu Arg Leu Arg Cys Ser Gly 
            100                 105                 110         


Gly Met Arg Leu Thr Ala Thr Tyr Arg Tyr Ile Leu Ser Cys His Cys 
        115                 120                 125             


Glu Glu Cys Asn Ser 
    130             


<210>  8
<211>  133
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  8

Met Arg Lys His Val Leu Ala Ala Ser Phe Ser Met Leu Ser Leu Leu 
1               5                   10                  15      


Val Ile Met Gly Asp Thr Asp Ser Lys Thr Asp Ser Ser Phe Ile Met 
            20                  25                  30          


Asp Ser Asp Pro Ala Arg Cys Met Arg His His Tyr Val Asp Ser Ile 
        35                  40                  45              


Ser His Pro Leu Tyr Lys Cys Ser Ser Lys Met Val Leu Leu Ala Arg 
    50                  55                  60                  


Cys Glu Gly His Cys Ser Gln Ala Ser Arg Ser Glu Pro Leu Val Ser 
65                  70                  75                  80  


Phe Ser Thr Val Leu Lys Gln Pro Phe Arg Ser Ser Cys His Cys Cys 
                85                  90                  95      


Arg Pro Gln Thr Ser Lys Leu Lys Ala Leu Arg Leu Arg Cys Ser Gly 
            100                 105                 110         


Gly Met Arg Leu Thr Ala Thr Tyr Arg Tyr Ile Leu Ser Cys His Cys 
        115                 120                 125             


Glu Glu Cys Asn Ser 
    130             


<210>  9
<211>  133
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  9

Met Arg Lys His Val Leu Ala Ala Ser Phe Ser Met Leu Ser Leu Leu 
1               5                   10                  15      


Val Ile Met Gly Asp Thr Asp Ser Lys Thr Asp Ser Ser Phe Ile Met 
            20                  25                  30          


Asp Ser Asp Pro Arg Ala Cys Met Arg His His Tyr Val Asp Ser Ile 
        35                  40                  45              


Ser His Pro Leu Tyr Lys Cys Ser Ser Lys Met Val Leu Leu Ala Arg 
    50                  55                  60                  


Cys Glu Gly His Cys Ser Gln Ala Ser Arg Ser Glu Pro Leu Val Ser 
65                  70                  75                  80  


Phe Ser Thr Val Leu Lys Gln Pro Phe Arg Ser Ser Cys His Cys Cys 
                85                  90                  95      


Arg Pro Gln Thr Ser Lys Leu Lys Ala Leu Arg Leu Arg Cys Ser Gly 
            100                 105                 110         


Gly Met Arg Leu Thr Ala Thr Tyr Arg Tyr Ile Leu Ser Cys His Cys 
        115                 120                 125             


Glu Glu Cys Asn Ser 
    130             


<210>  10
<211>  133
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  10

Met Arg Lys His Val Leu Ala Ala Ser Phe Ser Met Leu Ser Leu Leu 
1               5                   10                  15      


Val Ile Met Gly Asp Thr Asp Ser Lys Thr Asp Ser Ser Phe Ile Met 
            20                  25                  30          


Asp Ser Asp Pro Arg Arg Cys Met Arg His His Tyr Val Asp Ser Ile 
        35                  40                  45              


Ser His Pro Leu Tyr Lys Cys Ser Ser Lys Met Val Leu Leu Ala Arg 
    50                  55                  60                  


Cys Glu Gly His Cys Ser Gln Ala Ser Arg Ser Glu Pro Leu Val Ser 
65                  70                  75                  80  


Phe Ser Thr Val Leu Lys Gln Pro Phe Arg Ser Ser Cys His Cys Cys 
                85                  90                  95      


Arg Pro Gln Thr Ser Lys Leu Lys Ala Leu Arg Leu Arg Cys Ser Gly 
            100                 105                 110         


Gly Met Arg Leu Thr Ala Thr Ala Arg Tyr Ile Leu Ser Cys His Cys 
        115                 120                 125             


Glu Glu Cys Asn Ser 
    130             


<210>  11
<211>  133
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  11

Met Arg Lys His Val Leu Ala Ala Ser Phe Ser Met Leu Ser Leu Leu 
1               5                   10                  15      


Val Ile Met Gly Asp Thr Asp Ser Lys Thr Asp Ser Ser Phe Ile Met 
            20                  25                  30          


Asp Ser Asp Pro Arg Arg Cys Met Arg His His Tyr Val Asp Ser Ile 
        35                  40                  45              


Ser His Pro Leu Tyr Lys Cys Ser Ser Lys Met Val Leu Leu Ala Arg 
    50                  55                  60                  


Cys Glu Gly His Cys Ser Gln Ala Ser Arg Ser Glu Pro Leu Val Ser 
65                  70                  75                  80  


Phe Ser Thr Val Leu Lys Gln Pro Phe Arg Ser Ser Cys His Cys Cys 
                85                  90                  95      


Arg Pro Gln Thr Ser Lys Leu Lys Ala Leu Arg Leu Arg Cys Ser Gly 
            100                 105                 110         


Gly Met Arg Leu Thr Ala Thr Tyr Ala Tyr Ile Leu Ser Cys His Cys 
        115                 120                 125             


Glu Glu Cys Asn Ser 
    130             


<210>  12
<211>  133
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  12

Met Arg Lys His Val Leu Ala Ala Ser Phe Ser Met Leu Ser Leu Leu 
1               5                   10                  15      


Val Ile Met Gly Asp Thr Asp Ser Lys Thr Asp Ser Ser Phe Ile Met 
            20                  25                  30          


Asp Ser Asp Pro Arg Arg Cys Met Arg His His Tyr Val Asp Ser Ile 
        35                  40                  45              


Ser His Pro Leu Tyr Lys Cys Ser Ser Lys Met Val Leu Leu Ala Arg 
    50                  55                  60                  


Cys Glu Gly His Cys Ser Gln Ala Ser Arg Ser Glu Pro Leu Val Ser 
65                  70                  75                  80  


Phe Ser Thr Val Leu Lys Gln Pro Phe Arg Ser Ser Cys His Cys Cys 
                85                  90                  95      


Arg Pro Gln Thr Ser Lys Leu Lys Ala Leu Arg Leu Arg Cys Ser Gly 
            100                 105                 110         


Gly Met Arg Leu Thr Ala Thr Tyr Arg Ala Ile Leu Ser Cys His Cys 
        115                 120                 125             


Glu Glu Cys Asn Ser 
    130             


<210>  13
<211>  133
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  13

Met Arg Lys His Val Leu Ala Ala Ser Phe Ser Met Leu Ser Leu Leu 
1               5                   10                  15      


Val Ile Met Gly Asp Thr Asp Ser Lys Thr Asp Ser Ser Phe Ile Met 
            20                  25                  30          


Asp Ser Asp Pro Arg Arg Cys Met Arg His His Tyr Val Asp Ser Ile 
        35                  40                  45              


Ser His Pro Leu Tyr Lys Cys Ser Ser Lys Met Val Leu Leu Ala Arg 
    50                  55                  60                  


Cys Glu Gly His Cys Ser Gln Ala Ser Arg Ser Glu Pro Leu Val Ser 
65                  70                  75                  80  


Phe Ser Thr Val Leu Lys Gln Pro Phe Arg Ser Ser Cys His Cys Cys 
                85                  90                  95      


Arg Pro Gln Thr Ser Lys Leu Lys Ala Leu Arg Leu Arg Cys Ser Gly 
            100                 105                 110         


Gly Met Arg Leu Thr Ala Thr Tyr Arg Tyr Ile Leu Ser Cys Ala Cys 
        115                 120                 125             


Glu Glu Cys Asn Ser 
    130             


<210>  14
<211>  133
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  14

Met Arg Lys His Val Leu Ala Ala Ser Phe Ser Met Leu Ser Leu Leu 
1               5                   10                  15      


Val Ile Met Gly Asp Thr Asp Ser Lys Thr Asp Ser Ser Phe Ile Met 
            20                  25                  30          


Asp Ser Asp Pro Arg Arg Cys Met Arg His His Tyr Val Asp Ser Ile 
        35                  40                  45              


Ser His Pro Leu Tyr Lys Cys Ser Ser Lys Met Val Leu Leu Ala Arg 
    50                  55                  60                  


Cys Glu Gly His Cys Ser Gln Ala Ser Arg Ser Glu Pro Leu Val Ser 
65                  70                  75                  80  


Phe Ser Thr Val Leu Lys Gln Pro Phe Arg Ser Ser Cys His Cys Cys 
                85                  90                  95      


Arg Pro Gln Thr Ser Lys Leu Lys Ala Leu Arg Leu Arg Cys Ser Gly 
            100                 105                 110         


Gly Met Arg Leu Thr Ala Thr Tyr Arg Tyr Ile Leu Ser Cys His Cys 
        115                 120                 125             


Ala Glu Cys Asn Ser 
    130             


<210>  15
<211>  133
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  15

Met Arg Lys His Val Leu Ala Ala Ser Phe Ser Met Leu Ser Leu Leu 
1               5                   10                  15      


Val Ile Met Gly Asp Thr Asp Ser Lys Thr Asp Ser Ser Phe Ile Met 
            20                  25                  30          


Asp Ser Asp Pro Arg Arg Cys Met Arg His His Tyr Val Asp Ser Ile 
        35                  40                  45              


Ser His Pro Leu Tyr Lys Cys Ser Ser Lys Met Val Leu Leu Ala Arg 
    50                  55                  60                  


Cys Glu Gly His Cys Ser Gln Ala Ser Arg Ser Glu Pro Leu Val Ser 
65                  70                  75                  80  


Phe Ser Thr Val Leu Lys Gln Pro Phe Arg Ser Ser Cys His Cys Cys 
                85                  90                  95      


Arg Pro Gln Thr Ser Lys Leu Lys Ala Leu Arg Leu Arg Cys Ser Gly 
            100                 105                 110         


Gly Met Arg Leu Thr Ala Thr Tyr Arg Tyr Ile Leu Ser Cys His Cys 
        115                 120                 125             


Glu Ala Cys Asn Ser 
    130             


<210>  16
<211>  133
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  16

Met Arg Lys His Val Leu Ala Ala Ser Phe Ser Met Leu Ser Leu Leu 
1               5                   10                  15      


Val Ile Met Gly Asp Thr Asp Ser Lys Thr Asp Ser Ser Phe Ile Met 
            20                  25                  30          


Asp Ser Asp Pro Arg Arg Cys Met Arg His His Tyr Val Asp Ser Ile 
        35                  40                  45              


Ser His Pro Leu Tyr Lys Cys Ser Ser Lys Met Val Leu Leu Ala Arg 
    50                  55                  60                  


Cys Glu Gly His Cys Ser Gln Ala Ser Arg Ser Glu Pro Leu Val Ser 
65                  70                  75                  80  


Phe Ser Thr Val Leu Glu Gln Pro Phe Arg Ser Ser Cys His Cys Cys 
                85                  90                  95      


Arg Pro Gln Thr Ser Lys Leu Lys Ala Leu Arg Leu Arg Cys Ser Gly 
            100                 105                 110         


Gly Met Arg Leu Thr Ala Thr Tyr Arg Tyr Ile Leu Ser Cys His Cys 
        115                 120                 125             


Glu Glu Cys Asn Ser 
    130             


<210>  17
<211>  133
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  17

Met Arg Lys His Val Leu Ala Ala Ser Phe Ser Met Leu Ser Leu Leu 
1               5                   10                  15      


Val Ile Met Gly Asp Thr Asp Ser Lys Thr Asp Ser Ser Phe Ile Met 
            20                  25                  30          


Asp Ser Asp Pro Arg Arg Cys Met Arg His His Tyr Val Asp Ser Ile 
        35                  40                  45              


Ser His Pro Leu Tyr Lys Cys Ser Ser Lys Met Val Leu Leu Ala Arg 
    50                  55                  60                  


Cys Glu Gly His Cys Ser Gln Ala Ser Arg Ser Glu Pro Leu Val Ser 
65                  70                  75                  80  


Phe Ser Thr Val Leu Lys Gln Pro Phe Glu Ser Ser Cys His Cys Cys 
                85                  90                  95      


Arg Pro Gln Thr Ser Lys Leu Lys Ala Leu Arg Leu Arg Cys Ser Gly 
            100                 105                 110         


Gly Met Arg Leu Thr Ala Thr Tyr Arg Tyr Ile Leu Ser Cys His Cys 
        115                 120                 125             


Glu Glu Cys Asn Ser 
    130             


<210>  18
<211>  133
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  18

Met Arg Lys His Val Leu Ala Ala Ser Phe Ser Met Leu Ser Leu Leu 
1               5                   10                  15      


Val Ile Met Gly Asp Thr Asp Ser Lys Thr Asp Ser Ser Phe Ile Met 
            20                  25                  30          


Asp Ser Asp Pro Arg Arg Cys Met Arg His His Tyr Val Asp Ser Ile 
        35                  40                  45              


Ser His Pro Leu Tyr Lys Cys Ser Ser Lys Met Val Leu Leu Ala Arg 
    50                  55                  60                  


Cys Glu Gly His Cys Ser Gln Ala Ser Arg Ser Glu Pro Leu Val Ser 
65                  70                  75                  80  


Phe Ser Thr Val Leu Lys Gln Pro Phe Arg Ser Ser Cys His Cys Cys 
                85                  90                  95      


Glu Pro Gln Thr Ser Lys Leu Lys Ala Leu Arg Leu Arg Cys Ser Gly 
            100                 105                 110         


Gly Met Arg Leu Thr Ala Thr Tyr Arg Tyr Ile Leu Ser Cys His Cys 
        115                 120                 125             


Glu Glu Cys Asn Ser 
    130             


<210>  19
<211>  133
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  19

Met Arg Lys His Val Leu Ala Ala Ser Phe Ser Met Leu Ser Leu Leu 
1               5                   10                  15      


Val Ile Met Gly Asp Thr Asp Ser Lys Thr Asp Ser Ser Phe Ile Met 
            20                  25                  30          


Asp Ser Asp Pro Arg Arg Cys Met Arg His His Tyr Val Asp Ser Ile 
        35                  40                  45              


Ser His Pro Leu Tyr Lys Cys Ser Ser Lys Met Val Leu Leu Ala Arg 
    50                  55                  60                  


Cys Glu Gly His Cys Ser Gln Ala Ser Arg Ser Glu Pro Leu Val Ser 
65                  70                  75                  80  


Phe Ser Thr Val Leu Lys Gln Pro Phe Arg Ser Ser Cys His Cys Cys 
                85                  90                  95      


Arg Pro Gln Thr Ser Glu Leu Lys Ala Leu Arg Leu Arg Cys Ser Gly 
            100                 105                 110         


Gly Met Arg Leu Thr Ala Thr Tyr Arg Tyr Ile Leu Ser Cys His Cys 
        115                 120                 125             


Glu Glu Cys Asn Ser 
    130             


<210>  20
<211>  133
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  20

Met Arg Lys His Val Leu Ala Ala Ser Phe Ser Met Leu Ser Leu Leu 
1               5                   10                  15      


Val Ile Met Gly Asp Thr Asp Ser Lys Thr Asp Ser Ser Phe Ile Met 
            20                  25                  30          


Asp Ser Asp Pro Arg Arg Cys Met Arg His His Tyr Val Asp Ser Ile 
        35                  40                  45              


Ser His Pro Leu Tyr Lys Cys Ser Ser Lys Met Val Leu Leu Ala Arg 
    50                  55                  60                  


Cys Glu Gly His Cys Ser Gln Ala Ser Arg Ser Glu Pro Leu Val Ser 
65                  70                  75                  80  


Phe Ser Thr Val Leu Lys Gln Pro Phe Arg Ser Ser Cys His Cys Cys 
                85                  90                  95      


Arg Pro Gln Thr Ser Lys Leu Glu Ala Leu Arg Leu Arg Cys Ser Gly 
            100                 105                 110         


Gly Met Arg Leu Thr Ala Thr Tyr Arg Tyr Ile Leu Ser Cys His Cys 
        115                 120                 125             


Glu Glu Cys Asn Ser 
    130             


<210>  21
<211>  133
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  21

Met Arg Lys His Val Leu Ala Ala Ser Phe Ser Met Leu Ser Leu Leu 
1               5                   10                  15      


Val Ile Met Gly Asp Thr Asp Ser Lys Thr Asp Ser Ser Phe Ile Met 
            20                  25                  30          


Asp Ser Asp Pro Arg Arg Cys Met Arg His His Tyr Val Asp Ser Ile 
        35                  40                  45              


Ser His Pro Leu Tyr Lys Cys Ser Ser Lys Met Val Leu Leu Ala Arg 
    50                  55                  60                  


Cys Glu Gly His Cys Ser Gln Ala Ser Arg Ser Glu Pro Leu Val Ser 
65                  70                  75                  80  


Phe Ser Thr Val Leu Lys Gln Pro Phe Arg Ser Ser Cys His Cys Cys 
                85                  90                  95      


Arg Pro Gln Thr Ser Lys Leu Lys Ala Leu Arg Leu Arg Cys Ser Gly 
            100                 105                 110         


Gly Met Glu Leu Thr Ala Thr Tyr Arg Tyr Ile Leu Ser Cys His Cys 
        115                 120                 125             


Glu Glu Cys Asn Ser 
    130             


