                               SEQUENCE LISTING

<110> DANA-FARBER CANCER INSTITUTE, INC.
 
<120> COMPOSITIONS AND METHODS FOR MODULATING THE INTERACTION BETWEEN 
      SS18-SSX FUSION ONCOPROTEIN AND NUCLEOSOMES

<130> DFS-24825

<140> PCT/US2021/014367
<141> 2021-01-21

<150> 62/989,238
<151> 2020-03-13

<160> 244   

<170> PatentIn version 3.5

<210> 1
<211> 1309
<212> DNA
<213> Homo sapiens

<400> 1
accactgctg ccgacctcgc aaccactgct ttgtctctga atagagacag ggtttcctta       60

tgttggccga actgggcttg acctcctcgg ctcaagtgat cctcccacct cggcctcgga      120

actacaggtg agactgctcc tggtgccatg aacggagacg acacctttgc aaagagaccc      180

agggatgatg ctaaagcatc agagaagaga agcaaggcct ttgatgatat tgccacatac      240

ttctctaaga aagagtggaa aaagatgaaa tactcggaga aaatcagcta tgtgtatatg      300

aagagaaact ataaggccat gactaaacta ggtttcaaag tcaccctccc acctttcatg      360

tgtaataaac aggccacaga cttccagggg aatgattttg ataatgacca taaccgcagg      420

attcaggttg aacatcctca gatgactttc ggcaggctcc acagaatcat cccgaagatc      480

atgcccaaga agccagcaga ggacgaaaat gattcgaagg gagtgtcaga agcatctggc      540

ccacaaaacg atgggaaaca actgcacccc ccaggaaaag caaatatttc tgagaagatt      600

aataagagat ctggacccaa aagggggaaa catgcctgga cccacagact gcgtgagaga      660

aagcagctgg tgatttatga agagatcagt gaccctgagg aagatgacga gtaactcccc      720

tgggggatac gacacatgcc cttgatgaga agcagaacgt ggtgaccttt cacgaacatg      780

ggcatggctg cggctccctc gtcatcaggt gcatagcaag tgaaagcaag tgttcacaac      840

ggtgaaactt gagcgtcatt tttcttagtg tgccaagagt tcgatgttag tgtttccatt      900

gtattttctt acagtgtgcc attctgttag atactatcct tataattgat gagcaagaca      960

tactgaatgc atatttcggt ttgtgtatcc atgcacctac gtcagaaaac aagtattgtc     1020

aggtattctc tccatagaac agcactatcc tcatctctcc ccagatgtga ctactgaggg     1080

cagttctgag tgtttaattt cagacttttt cctctgcatt tacacacaca cacacacaca     1140

cacgcacaca cacacaccaa gtaccagtat aagcatctcc catctgcttt tcccattgcc     1200

atgcgtcctg gtcaagcccc cctcactctg tttcctgttc agcatgtact cccctcatcc     1260

gattcccctg tatcagtcac tgacagttaa taaacctttg caaacgttc                 1309


<210> 2
<211> 1223
<212> DNA
<213> Homo sapiens

<400> 2
accactgctg ccgacctcgc aaccactgct ttgtctctga agtgagactg ctcctggtgc       60

catgaacgga gacgacacct ttgcaaagag acccagggat gatgctaaag catcagagaa      120

gagaagcaag gcctttgatg atattgccac atacttctct aagaaagagt ggaaaaagat      180

gaaatactcg gagaaaatca gctatgtgta tatgaagaga aactataagg ccatgactaa      240

actaggtttc aaagtcaccc tcccaccttt catgtgtaat aaacaggcca cagacttcca      300

ggggaatgat tttgataatg accataaccg caggattcag gttgaacatc ctcagatgac      360

tttcggcagg ctccacagaa tcatcccgaa gatcatgccc aagaagccag cagaggacga      420

aaatgattcg aagggagtgt cagaagcatc tggcccacaa aacgatggga aacaactgca      480

ccccccagga aaagcaaata tttctgagaa gattaataag agatctggac ccaaaagggg      540

gaaacatgcc tggacccaca gactgcgtga gagaaagcag ctggtgattt atgaagagat      600

cagtgaccct gaggaagatg acgagtaact cccctggggg atacgacaca tgcccttgat      660

gagaagcaga acgtggtgac ctttcacgaa catgggcatg gctgcggctc cctcgtcatc      720

aggtgcatag caagtgaaag caagtgttca caacggtgaa acttgagcgt catttttctt      780

agtgtgccaa gagttcgatg ttagtgtttc cattgtattt tcttacagtg tgccattctg      840

ttagatacta tccttataat tgatgagcaa gacatactga atgcatattt cggtttgtgt      900

atccatgcac ctacgtcaga aaacaagtat tgtcaggtat tctctccata gaacagcact      960

atcctcatct ctccccagat gtgactactg agggcagttc tgagtgttta atttcagact     1020

ttttcctctg catttacaca cacacacaca cacacacgca cacacacaca ccaagtacca     1080

gtataagcat ctcccatctg cttttcccat tgccatgcgt cctggtcaag cccccctcac     1140

tctgtttcct gttcagcatg tactcccctc atccgattcc cctgtatcag tcactgacag     1200

ttaataaacc tttgcaaacg ttc                                             1223


<210> 3
<211> 188
<212> PRT
<213> Homo sapiens

<400> 3
Met Asn Gly Asp Asp Thr Phe Ala Lys Arg Pro Arg Asp Asp Ala Lys 
1               5                   10                  15      


Ala Ser Glu Lys Arg Ser Lys Ala Phe Asp Asp Ile Ala Thr Tyr Phe 
            20                  25                  30          


Ser Lys Lys Glu Trp Lys Lys Met Lys Tyr Ser Glu Lys Ile Ser Tyr 
        35                  40                  45              


Val Tyr Met Lys Arg Asn Tyr Lys Ala Met Thr Lys Leu Gly Phe Lys 
    50                  55                  60                  


Val Thr Leu Pro Pro Phe Met Cys Asn Lys Gln Ala Thr Asp Phe Gln 
65                  70                  75                  80  


Gly Asn Asp Phe Asp Asn Asp His Asn Arg Arg Ile Gln Val Glu His 
                85                  90                  95      


Pro Gln Met Thr Phe Gly Arg Leu His Arg Ile Ile Pro Lys Ile Met 
            100                 105                 110         


Pro Lys Lys Pro Ala Glu Asp Glu Asn Asp Ser Lys Gly Val Ser Glu 
        115                 120                 125             


Ala Ser Gly Pro Gln Asn Asp Gly Lys Gln Leu His Pro Pro Gly Lys 
    130                 135                 140                 


Ala Asn Ile Ser Glu Lys Ile Asn Lys Arg Ser Gly Pro Lys Arg Gly 
145                 150                 155                 160 


Lys His Ala Trp Thr His Arg Leu Arg Glu Arg Lys Gln Leu Val Ile 
                165                 170                 175     


Tyr Glu Glu Ile Ser Asp Pro Glu Glu Asp Asp Glu 
            180                 185             


<210> 4
<211> 1494
<212> DNA
<213> Homo sapiens

<400> 4
gggattggct actttaagtt cagagtacgc atgctctgac tttctctctc tttcgattct       60

tccatactca gagtacgcac ggtctgattt tctctttgga ttcttccaaa atcagagtca      120

gactgctccc ggtgccatga acggagacga cgcctttgca aggagaccca cggttggtgc      180

tcaaatacca gagaagatcc aaaaggcctt cgatgatatt gccaaatact tctctaagga      240

agagtgggaa aagatgaaag cctcggagaa aatcttctat gtgtatatga agagaaagta      300

tgaggctatg actaaactag gtttcaaggc caccctccca cctttcatgt gtaataaacg      360

ggccgaagac ttccagggga atgatttgga taatgaccct aaccgtggga atcaggttga      420

acgtcctcag atgactttcg gcaggctcca gggaatctcc ccgaagatca tgcccaagaa      480

gccagcagag gaaggaaatg attcggagga agtgccagaa gcatctggcc cacaaaatga      540

tgggaaagag ctgtgccccc cgggaaaacc aactacctct gagaagattc acgagagatc      600

tggaaatagg gaggcccaag aaaaggaaga gagacgcgga acagctcatc ggtggagcag      660

tcagaacaca cacaacattg gtcgattcag tttgtcaact tctatgggtg cagttcatgg      720

tacccccaaa acaattacac acaacaggga cccaaaaggg gggaacatgc ctggacccac      780

agactgcgtg agagaaaaca gctggtgatt tatgaagaga tcagcgaccc tgaggaagat      840

gacgagtaac tcccctcagg gatacgacac atgcccatga tgagaagcag aacgtggtga      900

cctttcacga acatgggcat ggctgcggac ccctcgtcat caggtgcata gcaagtgaaa      960

gcaagtgttc acaacagtga aaagttgagc gtcatttttc ttagtgtgcc aagagttcga     1020

tgttagcgtt tacgttgtat tttcttacac tgtgtcattc tgttagatac taacattttc     1080

attgatgagc aagacatact taatgcatat tttggtttgt gtatccatgc acctacctta     1140

gaaaacaagt attgtcggtt acctctgcat ggaacagcat taccctcctc tctccccaga     1200

tgtgactact gagggcagtt ctgagtgttt aatttcagat tttttcctct gcatttacac     1260

acacacgcac acaaaccaca ccacacacac acacacacac acacacacac acacacacac     1320

acaccaagta ccagtataag catctgccat ctgcttttcc cattgccatg cgtcctggtc     1380

aagctcccct cactctgttt cctggtcagc atgtactccc ctcatccgat tcccctgtag     1440

cagtcactga cagttaataa acctttgcaa acgttcaaaa aaaaaaaaaa aaaa           1494


<210> 5
<211> 223
<212> PRT
<213> Homo sapiens

<400> 5
Met Asn Gly Asp Asp Ala Phe Ala Arg Arg Pro Thr Val Gly Ala Gln 
1               5                   10                  15      


Ile Pro Glu Lys Ile Gln Lys Ala Phe Asp Asp Ile Ala Lys Tyr Phe 
            20                  25                  30          


Ser Lys Glu Glu Trp Glu Lys Met Lys Ala Ser Glu Lys Ile Phe Tyr 
        35                  40                  45              


Val Tyr Met Lys Arg Lys Tyr Glu Ala Met Thr Lys Leu Gly Phe Lys 
    50                  55                  60                  


Ala Thr Leu Pro Pro Phe Met Cys Asn Lys Arg Ala Glu Asp Phe Gln 
65                  70                  75                  80  


Gly Asn Asp Leu Asp Asn Asp Pro Asn Arg Gly Asn Gln Val Glu Arg 
                85                  90                  95      


Pro Gln Met Thr Phe Gly Arg Leu Gln Gly Ile Ser Pro Lys Ile Met 
            100                 105                 110         


Pro Lys Lys Pro Ala Glu Glu Gly Asn Asp Ser Glu Glu Val Pro Glu 
        115                 120                 125             


Ala Ser Gly Pro Gln Asn Asp Gly Lys Glu Leu Cys Pro Pro Gly Lys 
    130                 135                 140                 


Pro Thr Thr Ser Glu Lys Ile His Glu Arg Ser Gly Asn Arg Glu Ala 
145                 150                 155                 160 


Gln Glu Lys Glu Glu Arg Arg Gly Thr Ala His Arg Trp Ser Ser Gln 
                165                 170                 175     


Asn Thr His Asn Ile Gly Arg Phe Ser Leu Ser Thr Ser Met Gly Ala 
            180                 185                 190         


Val His Gly Thr Pro Lys Thr Ile Thr His Asn Arg Asp Pro Lys Gly 
        195                 200                 205             


Gly Asn Met Pro Gly Pro Thr Asp Cys Val Arg Glu Asn Ser Trp 
    210                 215                 220             


<210> 6
<211> 1348
<212> DNA
<213> Homo sapiens

<400> 6
gggattggct actttaagtt cagagtacgc atgctctgac tttctctctc tttcgattct       60

tccatactca gagtacgcac ggtctgattt tctctttgga ttcttccaaa atcagagtca      120

gactgctccc ggtgccatga acggagacga cgcctttgca aggagaccca cggttggtgc      180

tcaaatacca gagaagatcc aaaaggcctt cgatgatatt gccaaatact tctctaagga      240

agagtgggaa aagatgaaag cctcggagaa aatcttctat gtgtatatga agagaaagta      300

tgaggctatg actaaactag gtttcaaggc caccctccca cctttcatgt gtaataaacg      360

ggccgaagac ttccagggga atgatttgga taatgaccct aaccgtggga atcaggttga      420

acgtcctcag atgactttcg gcaggctcca gggaatctcc ccgaagatca tgcccaagaa      480

gccagcagag gaaggaaatg attcggagga agtgccagaa gcatctggcc cacaaaatga      540

tgggaaagag ctgtgccccc cgggaaaacc aactacctct gagaagattc acgagagatc      600

tggacccaaa aggggggaac atgcctggac ccacagactg cgtgagagaa aacagctggt      660

gatttatgaa gagatcagcg accctgagga agatgacgag taactcccct cagggatacg      720

acacatgccc atgatgagaa gcagaacgtg gtgacctttc acgaacatgg gcatggctgc      780

ggacccctcg tcatcaggtg catagcaagt gaaagcaagt gttcacaaca gtgaaaagtt      840

gagcgtcatt tttcttagtg tgccaagagt tcgatgttag cgtttacgtt gtattttctt      900

acactgtgtc attctgttag atactaacat tttcattgat gagcaagaca tacttaatgc      960

atattttggt ttgtgtatcc atgcacctac cttagaaaac aagtattgtc ggttacctct     1020

gcatggaaca gcattaccct cctctctccc cagatgtgac tactgagggc agttctgagt     1080

gtttaatttc agattttttc ctctgcattt acacacacac gcacacaaac cacaccacac     1140

acacacacac acacacacac acacacacac acacacacca agtaccagta taagcatctg     1200

ccatctgctt ttcccattgc catgcgtcct ggtcaagctc ccctcactct gtttcctggt     1260

cagcatgtac tcccctcatc cgattcccct gtagcagtca ctgacagtta ataaaccttt     1320

gcaaacgttc aaaaaaaaaa aaaaaaaa                                        1348


<210> 7
<211> 188
<212> PRT
<213> Homo sapiens

<400> 7
Met Asn Gly Asp Asp Ala Phe Ala Arg Arg Pro Thr Val Gly Ala Gln 
1               5                   10                  15      


Ile Pro Glu Lys Ile Gln Lys Ala Phe Asp Asp Ile Ala Lys Tyr Phe 
            20                  25                  30          


Ser Lys Glu Glu Trp Glu Lys Met Lys Ala Ser Glu Lys Ile Phe Tyr 
        35                  40                  45              


Val Tyr Met Lys Arg Lys Tyr Glu Ala Met Thr Lys Leu Gly Phe Lys 
    50                  55                  60                  


Ala Thr Leu Pro Pro Phe Met Cys Asn Lys Arg Ala Glu Asp Phe Gln 
65                  70                  75                  80  


Gly Asn Asp Leu Asp Asn Asp Pro Asn Arg Gly Asn Gln Val Glu Arg 
                85                  90                  95      


Pro Gln Met Thr Phe Gly Arg Leu Gln Gly Ile Ser Pro Lys Ile Met 
            100                 105                 110         


Pro Lys Lys Pro Ala Glu Glu Gly Asn Asp Ser Glu Glu Val Pro Glu 
        115                 120                 125             


Ala Ser Gly Pro Gln Asn Asp Gly Lys Glu Leu Cys Pro Pro Gly Lys 
    130                 135                 140                 


Pro Thr Thr Ser Glu Lys Ile His Glu Arg Ser Gly Pro Lys Arg Gly 
145                 150                 155                 160 


Glu His Ala Trp Thr His Arg Leu Arg Glu Arg Lys Gln Leu Val Ile 
                165                 170                 175     


Tyr Glu Glu Ile Ser Asp Pro Glu Glu Asp Asp Glu 
            180                 185             


<210> 8
<211> 1426
<212> DNA
<213> Homo sapiens

<400> 8
gggattggct actttaagtt cagagtacgc atgctctgac tttctctctc tttcgattct       60

tccatactca gagtacgcac ggtctgattt tctctttgga ttcttccaaa atcagagtca      120

gactgctccc ggtgccatga acggagacga cgcctttgca aggagaccca cggttggtgc      180

tcaaatacca gagaagatcc aaaaggcctt cgatgatatt gccaaatact tctctaagga      240

agagtgggaa aagatgaaag cctcggagaa aatcttctat gtgtatatga agagaaagta      300

tgaggctatg actaaactag gtttcaaggc caccctccca cctttcatgt gtaataaacg      360

ggccgaagac ttccagggga atgatttgga taatgaccct aaccgtggga atcaggttga      420

acgtcctcag atgactttcg gcaggctcca gggaatctcc ccgaagatca tgcccaagaa      480

gccagcagag gaaggaaatg attcggagga agtgccagaa gcatctggcc cacaaaatga      540

tgggaaagag ctgtgccccc cgggaaaacc aactacctct gagaagattc acgagagatc      600

tggaaatagg gaggcccaag aaaaggaaga gagacgcgga acagctcatc ggtggagcag      660

tcagaacaca cacaacattg gacccaaaag gggggaacat gcctggaccc acagactgcg      720

tgagagaaaa cagctggtga tttatgaaga gatcagcgac cctgaggaag atgacgagta      780

actcccctca gggatacgac acatgcccat gatgagaagc agaacgtggt gacctttcac      840

gaacatgggc atggctgcgg acccctcgtc atcaggtgca tagcaagtga aagcaagtgt      900

tcacaacagt gaaaagttga gcgtcatttt tcttagtgtg ccaagagttc gatgttagcg      960

tttacgttgt attttcttac actgtgtcat tctgttagat actaacattt tcattgatga     1020

gcaagacata cttaatgcat attttggttt gtgtatccat gcacctacct tagaaaacaa     1080

gtattgtcgg ttacctctgc atggaacagc attaccctcc tctctcccca gatgtgacta     1140

ctgagggcag ttctgagtgt ttaatttcag attttttcct ctgcatttac acacacacgc     1200

acacaaacca caccacacac acacacacac acacacacac acacacacac acacaccaag     1260

taccagtata agcatctgcc atctgctttt cccattgcca tgcgtcctgg tcaagctccc     1320

ctcactctgt ttcctggtca gcatgtactc ccctcatccg attcccctgt agcagtcact     1380

gacagttaat aaacctttgc aaacgttcaa aaaaaaaaaa aaaaaa                    1426


<210> 9
<211> 214
<212> PRT
<213> Homo sapiens

<400> 9
Met Asn Gly Asp Asp Ala Phe Ala Arg Arg Pro Thr Val Gly Ala Gln 
1               5                   10                  15      


Ile Pro Glu Lys Ile Gln Lys Ala Phe Asp Asp Ile Ala Lys Tyr Phe 
            20                  25                  30          


Ser Lys Glu Glu Trp Glu Lys Met Lys Ala Ser Glu Lys Ile Phe Tyr 
        35                  40                  45              


Val Tyr Met Lys Arg Lys Tyr Glu Ala Met Thr Lys Leu Gly Phe Lys 
    50                  55                  60                  


Ala Thr Leu Pro Pro Phe Met Cys Asn Lys Arg Ala Glu Asp Phe Gln 
65                  70                  75                  80  


Gly Asn Asp Leu Asp Asn Asp Pro Asn Arg Gly Asn Gln Val Glu Arg 
                85                  90                  95      


Pro Gln Met Thr Phe Gly Arg Leu Gln Gly Ile Ser Pro Lys Ile Met 
            100                 105                 110         


Pro Lys Lys Pro Ala Glu Glu Gly Asn Asp Ser Glu Glu Val Pro Glu 
        115                 120                 125             


Ala Ser Gly Pro Gln Asn Asp Gly Lys Glu Leu Cys Pro Pro Gly Lys 
    130                 135                 140                 


Pro Thr Thr Ser Glu Lys Ile His Glu Arg Ser Gly Asn Arg Glu Ala 
145                 150                 155                 160 


Gln Glu Lys Glu Glu Arg Arg Gly Thr Ala His Arg Trp Ser Ser Gln 
                165                 170                 175     


Asn Thr His Asn Ile Gly Pro Lys Arg Gly Glu His Ala Trp Thr His 
            180                 185                 190         


Arg Leu Arg Glu Arg Lys Gln Leu Val Ile Tyr Glu Glu Ile Ser Asp 
        195                 200                 205             


Pro Glu Glu Asp Asp Glu 
    210                 


<210> 10
<211> 1427
<212> DNA
<213> Homo sapiens

<400> 10
ctttcgattc ttccatactc agagtacgca cggtctgatt ttctctttgg attcttccaa       60

aatcagagtc agactgctcc cggtgccatg aacggagacg acgcctttgc aaggagaccc      120

acggttggtg ctcaaatacc agagaagatc caaaaggcct tcgatgatat tgccaaatac      180

ttctctaagg aagagtggga aaagatgaaa gcctcggaga aaatcttcta tgtgtatatg      240

aagagaaagt atgaggctat gactaaacta ggtttcaagg ccaccctccc acctttcatg      300

tgtaataaac gggccgaaga cttccagggg aatgatttgg ataatgaccc taaccgtggg      360

aatcaggttg aacgtcctca gatgactttc ggcaggctcc agggaatctc cccgaagatc      420

atgcccaaga agccagcaga ggaaggaaat gattcggagg aagtgccaga agcatctggc      480

ccacaaaatg atgggaaaga gctgtgcccc ccgggaaaac caactacctc tgagaagatt      540

cacgagagat ctggaaatag ggaggcccaa gaaaaggaag agagacgcgg aacagctcat      600

cggtggagca gtcagaacac acacaacatt ggtcgattca gtttgtcaac ttctatgggt      660

gcagttcatg gtacccccaa aacaattaca cacaacaggg acccaaaagg ggggaacatg      720

cctggaccca cagactgcgt gagagaaaac agctggtgat ttatgaagag atcagcgacc      780

ctgaggaaga tgacgagtaa ctcccctcag ggatacgaca catgcccatg atgagaagca      840

gaacgtggtg acctttcacg aacatgggca tggctgcgga cccctcgtca tcaggtgcat      900

agcaagtgaa agcaagtgtt cacaacagtg aaaagttgag cgtcattttt cttagtgtgc      960

caagagttcg atgttagcgt ttacgttgta ttttcttaca ctgtgtcatt ctgttagata     1020

ctaacatttt cattgatgag caagacatac ttaatgcata ttttggtttg tgtatccatg     1080

cacctacctt agaaaacaag tattgtcggt tacctctgca tggaacagca ttaccctcct     1140

ctctccccag atgtgactac tgagggcagt tctgagtgtt taatttcaga ttttttcctc     1200

tgcatttaca cacacacgca cacaaaccac accacacaca cacacacaca cacacacaca     1260

cacacacaca cacaccaagt accagtataa gcatctgcca tctgcttttc ccattgccat     1320

gcgtcctggt caagctcccc tcactctgtt tcctggtcag catgtactcc cctcatccga     1380

ttcccctgta gcagtcactg acagttaata aacctttgca aacgttc                   1427


<210> 11
<211> 223
<212> PRT
<213> Homo sapiens

<400> 11
Met Asn Gly Asp Asp Ala Phe Ala Arg Arg Pro Thr Val Gly Ala Gln 
1               5                   10                  15      


Ile Pro Glu Lys Ile Gln Lys Ala Phe Asp Asp Ile Ala Lys Tyr Phe 
            20                  25                  30          


Ser Lys Glu Glu Trp Glu Lys Met Lys Ala Ser Glu Lys Ile Phe Tyr 
        35                  40                  45              


Val Tyr Met Lys Arg Lys Tyr Glu Ala Met Thr Lys Leu Gly Phe Lys 
    50                  55                  60                  


Ala Thr Leu Pro Pro Phe Met Cys Asn Lys Arg Ala Glu Asp Phe Gln 
65                  70                  75                  80  


Gly Asn Asp Leu Asp Asn Asp Pro Asn Arg Gly Asn Gln Val Glu Arg 
                85                  90                  95      


Pro Gln Met Thr Phe Gly Arg Leu Gln Gly Ile Ser Pro Lys Ile Met 
            100                 105                 110         


Pro Lys Lys Pro Ala Glu Glu Gly Asn Asp Ser Glu Glu Val Pro Glu 
        115                 120                 125             


Ala Ser Gly Pro Gln Asn Asp Gly Lys Glu Leu Cys Pro Pro Gly Lys 
    130                 135                 140                 


Pro Thr Thr Ser Glu Lys Ile His Glu Arg Ser Gly Asn Arg Glu Ala 
145                 150                 155                 160 


Gln Glu Lys Glu Glu Arg Arg Gly Thr Ala His Arg Trp Ser Ser Gln 
                165                 170                 175     


Asn Thr His Asn Ile Gly Arg Phe Ser Leu Ser Thr Ser Met Gly Ala 
            180                 185                 190         


Val His Gly Thr Pro Lys Thr Ile Thr His Asn Arg Asp Pro Lys Gly 
        195                 200                 205             


Gly Asn Met Pro Gly Pro Thr Asp Cys Val Arg Glu Asn Ser Trp 
    210                 215                 220             


<210> 12
<211> 1281
<212> DNA
<213> Homo sapiens

<400> 12
ctttcgattc ttccatactc agagtacgca cggtctgatt ttctctttgg attcttccaa       60

aatcagagtc agactgctcc cggtgccatg aacggagacg acgcctttgc aaggagaccc      120

acggttggtg ctcaaatacc agagaagatc caaaaggcct tcgatgatat tgccaaatac      180

ttctctaagg aagagtggga aaagatgaaa gcctcggaga aaatcttcta tgtgtatatg      240

aagagaaagt atgaggctat gactaaacta ggtttcaagg ccaccctccc acctttcatg      300

tgtaataaac gggccgaaga cttccagggg aatgatttgg ataatgaccc taaccgtggg      360

aatcaggttg aacgtcctca gatgactttc ggcaggctcc agggaatctc cccgaagatc      420

atgcccaaga agccagcaga ggaaggaaat gattcggagg aagtgccaga agcatctggc      480

ccacaaaatg atgggaaaga gctgtgcccc ccgggaaaac caactacctc tgagaagatt      540

cacgagagat ctggacccaa aaggggggaa catgcctgga cccacagact gcgtgagaga      600

aaacagctgg tgatttatga agagatcagc gaccctgagg aagatgacga gtaactcccc      660

tcagggatac gacacatgcc catgatgaga agcagaacgt ggtgaccttt cacgaacatg      720

ggcatggctg cggacccctc gtcatcaggt gcatagcaag tgaaagcaag tgttcacaac      780

agtgaaaagt tgagcgtcat ttttcttagt gtgccaagag ttcgatgtta gcgtttacgt      840

tgtattttct tacactgtgt cattctgtta gatactaaca ttttcattga tgagcaagac      900

atacttaatg catattttgg tttgtgtatc catgcaccta ccttagaaaa caagtattgt      960

cggttacctc tgcatggaac agcattaccc tcctctctcc ccagatgtga ctactgaggg     1020

cagttctgag tgtttaattt cagatttttt cctctgcatt tacacacaca cgcacacaaa     1080

ccacaccaca cacacacaca cacacacaca cacacacaca cacacacacc aagtaccagt     1140

ataagcatct gccatctgct tttcccattg ccatgcgtcc tggtcaagct cccctcactc     1200

tgtttcctgg tcagcatgta ctcccctcat ccgattcccc tgtagcagtc actgacagtt     1260

aataaacctt tgcaaacgtt c                                               1281


<210> 13
<211> 188
<212> PRT
<213> Homo sapiens

<400> 13
Met Asn Gly Asp Asp Ala Phe Ala Arg Arg Pro Thr Val Gly Ala Gln 
1               5                   10                  15      


Ile Pro Glu Lys Ile Gln Lys Ala Phe Asp Asp Ile Ala Lys Tyr Phe 
            20                  25                  30          


Ser Lys Glu Glu Trp Glu Lys Met Lys Ala Ser Glu Lys Ile Phe Tyr 
        35                  40                  45              


Val Tyr Met Lys Arg Lys Tyr Glu Ala Met Thr Lys Leu Gly Phe Lys 
    50                  55                  60                  


Ala Thr Leu Pro Pro Phe Met Cys Asn Lys Arg Ala Glu Asp Phe Gln 
65                  70                  75                  80  


Gly Asn Asp Leu Asp Asn Asp Pro Asn Arg Gly Asn Gln Val Glu Arg 
                85                  90                  95      


Pro Gln Met Thr Phe Gly Arg Leu Gln Gly Ile Ser Pro Lys Ile Met 
            100                 105                 110         


Pro Lys Lys Pro Ala Glu Glu Gly Asn Asp Ser Glu Glu Val Pro Glu 
        115                 120                 125             


Ala Ser Gly Pro Gln Asn Asp Gly Lys Glu Leu Cys Pro Pro Gly Lys 
    130                 135                 140                 


Pro Thr Thr Ser Glu Lys Ile His Glu Arg Ser Gly Pro Lys Arg Gly 
145                 150                 155                 160 


Glu His Ala Trp Thr His Arg Leu Arg Glu Arg Lys Gln Leu Val Ile 
                165                 170                 175     


Tyr Glu Glu Ile Ser Asp Pro Glu Glu Asp Asp Glu 
            180                 185             


<210> 14
<211> 1359
<212> DNA
<213> Homo sapiens

<400> 14
ctttcgattc ttccatactc agagtacgca cggtctgatt ttctctttgg attcttccaa       60

aatcagagtc agactgctcc cggtgccatg aacggagacg acgcctttgc aaggagaccc      120

acggttggtg ctcaaatacc agagaagatc caaaaggcct tcgatgatat tgccaaatac      180

ttctctaagg aagagtggga aaagatgaaa gcctcggaga aaatcttcta tgtgtatatg      240

aagagaaagt atgaggctat gactaaacta ggtttcaagg ccaccctccc acctttcatg      300

tgtaataaac gggccgaaga cttccagggg aatgatttgg ataatgaccc taaccgtggg      360

aatcaggttg aacgtcctca gatgactttc ggcaggctcc agggaatctc cccgaagatc      420

atgcccaaga agccagcaga ggaaggaaat gattcggagg aagtgccaga agcatctggc      480

ccacaaaatg atgggaaaga gctgtgcccc ccgggaaaac caactacctc tgagaagatt      540

cacgagagat ctggaaatag ggaggcccaa gaaaaggaag agagacgcgg aacagctcat      600

cggtggagca gtcagaacac acacaacatt ggacccaaaa ggggggaaca tgcctggacc      660

cacagactgc gtgagagaaa acagctggtg atttatgaag agatcagcga ccctgaggaa      720

gatgacgagt aactcccctc agggatacga cacatgccca tgatgagaag cagaacgtgg      780

tgacctttca cgaacatggg catggctgcg gacccctcgt catcaggtgc atagcaagtg      840

aaagcaagtg ttcacaacag tgaaaagttg agcgtcattt ttcttagtgt gccaagagtt      900

cgatgttagc gtttacgttg tattttctta cactgtgtca ttctgttaga tactaacatt      960

ttcattgatg agcaagacat acttaatgca tattttggtt tgtgtatcca tgcacctacc     1020

ttagaaaaca agtattgtcg gttacctctg catggaacag cattaccctc ctctctcccc     1080

agatgtgact actgagggca gttctgagtg tttaatttca gattttttcc tctgcattta     1140

cacacacacg cacacaaacc acaccacaca cacacacaca cacacacaca cacacacaca     1200

cacacaccaa gtaccagtat aagcatctgc catctgcttt tcccattgcc atgcgtcctg     1260

gtcaagctcc cctcactctg tttcctggtc agcatgtact cccctcatcc gattcccctg     1320

tagcagtcac tgacagttaa taaacctttg caaacgttc                            1359


<210> 15
<211> 214
<212> PRT
<213> Homo sapiens

<400> 15
Met Asn Gly Asp Asp Ala Phe Ala Arg Arg Pro Thr Val Gly Ala Gln 
1               5                   10                  15      


Ile Pro Glu Lys Ile Gln Lys Ala Phe Asp Asp Ile Ala Lys Tyr Phe 
            20                  25                  30          


Ser Lys Glu Glu Trp Glu Lys Met Lys Ala Ser Glu Lys Ile Phe Tyr 
        35                  40                  45              


Val Tyr Met Lys Arg Lys Tyr Glu Ala Met Thr Lys Leu Gly Phe Lys 
    50                  55                  60                  


Ala Thr Leu Pro Pro Phe Met Cys Asn Lys Arg Ala Glu Asp Phe Gln 
65                  70                  75                  80  


Gly Asn Asp Leu Asp Asn Asp Pro Asn Arg Gly Asn Gln Val Glu Arg 
                85                  90                  95      


Pro Gln Met Thr Phe Gly Arg Leu Gln Gly Ile Ser Pro Lys Ile Met 
            100                 105                 110         


Pro Lys Lys Pro Ala Glu Glu Gly Asn Asp Ser Glu Glu Val Pro Glu 
        115                 120                 125             


Ala Ser Gly Pro Gln Asn Asp Gly Lys Glu Leu Cys Pro Pro Gly Lys 
    130                 135                 140                 


Pro Thr Thr Ser Glu Lys Ile His Glu Arg Ser Gly Asn Arg Glu Ala 
145                 150                 155                 160 


Gln Glu Lys Glu Glu Arg Arg Gly Thr Ala His Arg Trp Ser Ser Gln 
                165                 170                 175     


Asn Thr His Asn Ile Gly Pro Lys Arg Gly Glu His Ala Trp Thr His 
            180                 185                 190         


Arg Leu Arg Glu Arg Lys Gln Leu Val Ile Tyr Glu Glu Ile Ser Asp 
        195                 200                 205             


Pro Glu Glu Asp Asp Glu 
    210                 


<210> 16
<211> 1209
<212> DNA
<213> Homo sapiens

<400> 16
gcccttttga ttcttccaca atcagggtga gactgctccc agtgccatga acggagacga       60

cgcctttgca aggagaccca gggatgatgc tcaaatatca gagaagttac gaaaggcctt      120

cgatgatatt gccaaatact tctctaagaa agagtgggaa aagatgaaat cctcggagaa      180

aatcgtctat gtgtatatga agctaaacta tgaggtcatg actaaactag gtttcaaggt      240

caccctccca cctttcatgc gtagtaaacg ggctgcagac ttccacggga atgattttgg      300

taacgatcga aaccacagga atcaggttga acgtcctcag atgactttcg gcagcctcca      360

gagaatcttc ccgaagatca tgcccaagaa gccagcagag gaagaaaatg gtttgaagga      420

agtgccagag gcatctggcc cacaaaatga tgggaaacag ctgtgccccc cgggaaatcc      480

aagtaccttg gagaagatta acaagacatc tggacccaaa agggggaaac atgcctggac      540

ccacagactg cgtgagagaa agcagctggt ggtttatgaa gagatcagcg accctgagga      600

agatgacgag taactcccct cggggatatg acacatgccc atgatgagaa gcagaacgtg      660

gtgacctttc acgaacatgg gcatggctgc ggacccctcg tcatcaggtg catagcaagt      720

gaaagcaagt gttcacaaca gtgaaaagtt gagcgtcatt tttcttagtg tgccaagagt      780

tcgatgttgg cgtttccgct gtattttctt gcagtgtgcc attctgttag acattagcgt      840

tttcgttgat gagcaagaca tgcttaatgc atatttcggc ttgtgtatcc atgcacctac      900

ctcagaaaac aagtattgtc aggtattctc tccatagaac agcactaccc tcctctctcc      960

ccagatgtga ctactgaggg gaggtctgag tgtttaattt ccgatttttt cctctgcatt     1020

tacacacaca ccacacacgc acacacacac accaagtacc agtataagca tctcccatct     1080

gcttttctcc attgccatgc gacctggtca agcccccctc actctgtttc ctgttcagca     1140

tgtactcccc tcatccgatt ccgttgtatc agtcactgac agttaataaa cctttgcaaa     1200

cgttcccca                                                             1209


<210> 17
<211> 188
<212> PRT
<213> Homo sapiens

<400> 17
Met Asn Gly Asp Asp Ala Phe Ala Arg Arg Pro Arg Asp Asp Ala Gln 
1               5                   10                  15      


Ile Ser Glu Lys Leu Arg Lys Ala Phe Asp Asp Ile Ala Lys Tyr Phe 
            20                  25                  30          


Ser Lys Lys Glu Trp Glu Lys Met Lys Ser Ser Glu Lys Ile Val Tyr 
        35                  40                  45              


Val Tyr Met Lys Leu Asn Tyr Glu Val Met Thr Lys Leu Gly Phe Lys 
    50                  55                  60                  


Val Thr Leu Pro Pro Phe Met Arg Ser Lys Arg Ala Ala Asp Phe His 
65                  70                  75                  80  


Gly Asn Asp Phe Gly Asn Asp Arg Asn His Arg Asn Gln Val Glu Arg 
                85                  90                  95      


Pro Gln Met Thr Phe Gly Ser Leu Gln Arg Ile Phe Pro Lys Ile Met 
            100                 105                 110         


Pro Lys Lys Pro Ala Glu Glu Glu Asn Gly Leu Lys Glu Val Pro Glu 
        115                 120                 125             


Ala Ser Gly Pro Gln Asn Asp Gly Lys Gln Leu Cys Pro Pro Gly Asn 
    130                 135                 140                 


Pro Ser Thr Leu Glu Lys Ile Asn Lys Thr Ser Gly Pro Lys Arg Gly 
145                 150                 155                 160 


Lys His Ala Trp Thr His Arg Leu Arg Glu Arg Lys Gln Leu Val Val 
                165                 170                 175     


Tyr Glu Glu Ile Ser Asp Pro Glu Glu Asp Asp Glu 
            180                 185             


<210> 18
<211> 1114
<212> DNA
<213> Homo sapiens

<400> 18
acacgccgat ttgccctttt gattcttcca caatcagggt gagactgctc ccagtgccat       60

gaacggagac gacgcctttg caaggagacc cagggatgat gctcaaatat cagagaagtt      120

acgaaaggcc ttcgatgata ttgccaaata cttctctaag aaagagtggg aaaagatgaa      180

atcctcggag aaaatcgtct atgtgtatat gaagctaaac tatgaggtca tgactaaact      240

aggtttcaag gtcaccctcc cacctttcat gcgtagtaaa cgggctgcag acttccacgg      300

gaatgatttt ggtaacgatc gaaaccacag gaatcaggtt gaacgtcctc agatgacttt      360

cggcagcctc cagagaatct tcccgaagga cccaaaaggg ggaaacatgc ctggacccac      420

agactgcgtg agagaaagca gctggtggtt tatgaagaga tcagcgaccc tgaggaagat      480

gacgagtaac tcccctcggg gatatgacac atgcccatga tgagaagcag aacgtggtga      540

cctttcacga acatgggcat ggctgcggac ccctcgtcat caggtgcata gcaagtgaaa      600

gcaagtgttc acaacagtga aaagttgagc gtcatttttc ttagtgtgcc aagagttcga      660

tgttggcgtt tccgctgtat tttcttgcag tgtgccattc tgttagacat tagcgttttc      720

gttgatgagc aagacatgct taatgcatat ttcggcttgt gtatccatgc acctacctca      780

gaaaacaagt attgtcaggt attctctcca tagaacagca ctaccctcct ctctccccag      840

atgtgactac tgaggggagg tctgagtgtt taatttccga ttttttcctc tgcatttaca      900

cacacaccac acacgcacac acacacacca agtaccagta taagcatctc ccatctgctt      960

ttctccattg ccatgcgacc tggtcaagcc cccctcactc tgtttcctgt tcagcatgta     1020

ctcccctcat ccgattccgt tgtatcagtc actgacagtt aataaacctt tgcaaacgtt     1080

caaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaa                                 1114


<210> 19
<211> 153
<212> PRT
<213> Homo sapiens

<400> 19
Met Asn Gly Asp Asp Ala Phe Ala Arg Arg Pro Arg Asp Asp Ala Gln 
1               5                   10                  15      


Ile Ser Glu Lys Leu Arg Lys Ala Phe Asp Asp Ile Ala Lys Tyr Phe 
            20                  25                  30          


Ser Lys Lys Glu Trp Glu Lys Met Lys Ser Ser Glu Lys Ile Val Tyr 
        35                  40                  45              


Val Tyr Met Lys Leu Asn Tyr Glu Val Met Thr Lys Leu Gly Phe Lys 
    50                  55                  60                  


Val Thr Leu Pro Pro Phe Met Arg Ser Lys Arg Ala Ala Asp Phe His 
65                  70                  75                  80  


Gly Asn Asp Phe Gly Asn Asp Arg Asn His Arg Asn Gln Val Glu Arg 
                85                  90                  95      


Pro Gln Met Thr Phe Gly Ser Leu Gln Arg Ile Phe Pro Lys Asp Pro 
            100                 105                 110         


Lys Gly Gly Asn Met Pro Gly Pro Thr Asp Cys Val Arg Glu Ser Ser 
        115                 120                 125             


Trp Trp Phe Met Lys Arg Ser Ala Thr Leu Arg Lys Met Thr Ser Asn 
    130                 135                 140                 


Ser Pro Arg Gly Tyr Asp Thr Cys Pro 
145                 150             


<210> 20
<211> 1244
<212> DNA
<213> Homo sapiens

<400> 20
tcagagtacg cacacgccga tttgcccttt tgattcttcc acaatcaggg tgagactgct       60

cccagtgcca tgaacggaga cgacgccttt gcaaggagac ccagggatga tgctcaaata      120

tcagagaagt tacgaaaggc cttcgatgat attgccaaat acttctctaa gaaagagtgg      180

gaaaagatga aatcctcgga gaaaatcgtc tatgtgtata tgaagctaaa ctatgaggtc      240

atgactaaac taggtttcaa ggtcaccctc ccacctttca tgcgtagtaa acgggctgca      300

gacttccacg ggaatgattt tggtaacgat cgaaaccaca ggaatcaggt tgaacgtcct      360

cagatgactt tcggcagcct ccagagaatc ttcccgaaga tcatgcccaa gaagccagca      420

gaggaagaaa atggtttgaa ggaagtgcca gaggcatctg gcccacaaaa tgatgggaaa      480

cagctgtgcc ccccgggaaa tccaagtacc ttggagaaga ttaacaagac atctggaccc      540

aaaaggggga aacatgcctg gacccacaga ctgcgtgaga gaaagcagct ggtggtttat      600

gaagagatca gcgaccctga ggaagatgac gagtaactcc cctcggggat atgacacatg      660

cccatgatga gaagcagaac gtggtgacct ttcacgaaca tgggcatggc tgcggacccc      720

tcgtcatcag gtgcatagca agtgaaagca agtgttcaca acagtgaaaa gttgagcgtc      780

atttttctta gtgtgccaag agttcgatgt tggcgtttcc gctgtatttt cttgcagtgt      840

gccattctgt tagacattag cgttttcgtt gatgagcaag acatgcttaa tgcatatttc      900

ggcttgtgta tccatgcacc tacctcagaa aacaagtatt gtcaggtatt ctctccatag      960

aacagcacta ccctcctctc tccccagatg tgactactga ggggaggtct gagtgtttaa     1020

tttccgattt tttcctctgc atttacacac acaccacaca cgcacacaca cacaccaagt     1080

accagtataa gcatctccca tctgcttttc tccattgcca tgcgacctgg tcaagccccc     1140

ctcactctgt ttcctgttca gcatgtactc ccctcatccg attccgttgt atcagtcact     1200

gacagttaat aaacctttgc aaacgttcaa aaaaaaaaaa aaaa                      1244


<210> 21
<211> 188
<212> PRT
<213> Homo sapiens

<400> 21
Met Asn Gly Asp Asp Ala Phe Ala Arg Arg Pro Arg Asp Asp Ala Gln 
1               5                   10                  15      


Ile Ser Glu Lys Leu Arg Lys Ala Phe Asp Asp Ile Ala Lys Tyr Phe 
            20                  25                  30          


Ser Lys Lys Glu Trp Glu Lys Met Lys Ser Ser Glu Lys Ile Val Tyr 
        35                  40                  45              


Val Tyr Met Lys Leu Asn Tyr Glu Val Met Thr Lys Leu Gly Phe Lys 
    50                  55                  60                  


Val Thr Leu Pro Pro Phe Met Arg Ser Lys Arg Ala Ala Asp Phe His 
65                  70                  75                  80  


Gly Asn Asp Phe Gly Asn Asp Arg Asn His Arg Asn Gln Val Glu Arg 
                85                  90                  95      


Pro Gln Met Thr Phe Gly Ser Leu Gln Arg Ile Phe Pro Lys Ile Met 
            100                 105                 110         


Pro Lys Lys Pro Ala Glu Glu Glu Asn Gly Leu Lys Glu Val Pro Glu 
        115                 120                 125             


Ala Ser Gly Pro Gln Asn Asp Gly Lys Gln Leu Cys Pro Pro Gly Asn 
    130                 135                 140                 


Pro Ser Thr Leu Glu Lys Ile Asn Lys Thr Ser Gly Pro Lys Arg Gly 
145                 150                 155                 160 


Lys His Ala Trp Thr His Arg Leu Arg Glu Arg Lys Gln Leu Val Val 
                165                 170                 175     


Tyr Glu Glu Ile Ser Asp Pro Glu Glu Asp Asp Glu 
            180                 185             


<210> 22
<211> 1108
<212> DNA
<213> Homo sapiens

<400> 22
tcagagtacg cacacgccga tttgcccttt tgattcttcc acaatcaggg tgagactgct       60

cccagtgcca tgaacggaga cgacgccttt gcaaggagac ccagggatga tgctcaaata      120

tcagagaagt tacgaaaggc cttcgatgat attgccaaat acttctctaa gaaagagtgg      180

gaaaagatga aatcctcgga gaaaatcgtc tatgtgtata tgaagctaaa ctatgaggtc      240

atgactaaac taggtttcaa ggtcaccctc ccacctttca tgcgtagtaa acgggctgca      300

gacttccacg ggaatgattt tggtaacgat cgaaaccaca ggaatcaggt tgaacgtcct      360

cagatgactt tcggcagcct ccagagaatc ttcccgaagg acccaaaagg gggaaacatg      420

cctggaccca cagactgcgt gagagaaagc agctggtggt ttatgaagag atcagcgacc      480

ctgaggaaga tgacgagtaa ctcccctcgg ggatatgaca catgcccatg atgagaagca      540

gaacgtggtg acctttcacg aacatgggca tggctgcgga cccctcgtca tcaggtgcat      600

agcaagtgaa agcaagtgtt cacaacagtg aaaagttgag cgtcattttt cttagtgtgc      660

caagagttcg atgttggcgt ttccgctgta ttttcttgca gtgtgccatt ctgttagaca      720

ttagcgtttt cgttgatgag caagacatgc ttaatgcata tttcggcttg tgtatccatg      780

cacctacctc agaaaacaag tattgtcagg tattctctcc atagaacagc actaccctcc      840

tctctcccca gatgtgacta ctgaggggag gtctgagtgt ttaatttccg attttttcct      900

ctgcatttac acacacacca cacacgcaca cacacacacc aagtaccagt ataagcatct      960

cccatctgct tttctccatt gccatgcgac ctggtcaagc ccccctcact ctgtttcctg     1020

ttcagcatgt actcccctca tccgattccg ttgtatcagt cactgacagt taataaacct     1080

ttgcaaacgt tcaaaaaaaa aaaaaaaa                                        1108


<210> 23
<211> 153
<212> PRT
<213> Homo sapiens

<400> 23
Met Asn Gly Asp Asp Ala Phe Ala Arg Arg Pro Arg Asp Asp Ala Gln 
1               5                   10                  15      


Ile Ser Glu Lys Leu Arg Lys Ala Phe Asp Asp Ile Ala Lys Tyr Phe 
            20                  25                  30          


Ser Lys Lys Glu Trp Glu Lys Met Lys Ser Ser Glu Lys Ile Val Tyr 
        35                  40                  45              


Val Tyr Met Lys Leu Asn Tyr Glu Val Met Thr Lys Leu Gly Phe Lys 
    50                  55                  60                  


Val Thr Leu Pro Pro Phe Met Arg Ser Lys Arg Ala Ala Asp Phe His 
65                  70                  75                  80  


Gly Asn Asp Phe Gly Asn Asp Arg Asn His Arg Asn Gln Val Glu Arg 
                85                  90                  95      


Pro Gln Met Thr Phe Gly Ser Leu Gln Arg Ile Phe Pro Lys Asp Pro 
            100                 105                 110         


Lys Gly Gly Asn Met Pro Gly Pro Thr Asp Cys Val Arg Glu Ser Ser 
        115                 120                 125             


Trp Trp Phe Met Lys Arg Ser Ala Thr Leu Arg Lys Met Thr Ser Asn 
    130                 135                 140                 


Ser Pro Arg Gly Tyr Asp Thr Cys Pro 
145                 150             


<210> 24
<211> 1270
<212> DNA
<213> Homo sapiens

<400> 24
ctctttcgat tcttccatac tcaagagtac gcacggtctg attttctctt tggattcttc       60

caaaatcaga gtcagactac tccctgtgcc atgaacggag atgacacctt tgcaaggaga      120

cccacggttg gtgctcaaat accagagaag atacaaaagg ccttcgatga tattgccaaa      180

tacttctcta aggaagagtg ggaaaagatg aaagtctcgg agaaaatcgt ctatgtgtat      240

atgaagagaa agtatgaggc catgactaaa ctaggtttca aggccatcct cccatctttc      300

atgcgtaata aacgggtcac agacttccag gggaatgatt ttgataatga ccctaaccgt      360

gggaatcagg ttcaacgtcc tcagatgact ttcggcaggc tccagggaat cttcccgaag      420

atcatgccca agaagccagc agaggaagga aatgtttcga aggaagtgcc agaagcatct      480

ggcccacaaa acgatgggaa acagctgtgc cccccgggaa aaccaactac ctctgagaag      540

attaacatga tatctggacc caaaaggggg gaacatgcct ggacccacag actgcgtgag      600

agaaagcagc tggtgattta tgaagagatc agcgatcctg aggaagatga tgagtaactc      660

cccttgggga tatgacacat gcccatgatg agaagcagaa cgtggtgacc tttcacgaac      720

atgggcatgg ctgtggaccc ctcgtcatca ggtgcatagc aagtgaaagc aagtgttcac      780

aacagtgaaa agttgagcgt catttttctt agtgtgccaa gagtacgata ttagcgtttc      840

cattgtattt tcttgaagtg tgtcattctg ttagatatta acattttcac tgatgagcaa      900

gacatactta atgcatattt tggtttgtgt atccatgcac ctaccttaga aaacaagtat      960

tgtcagttac ctctgcatgg aacagcatta ccctcctctc tccctagatg tgactactga     1020

gggcagttct gagtgtttaa tttcagattt tttcctctgc atttacacac acacacaaac     1080

cacaccacac acacacacac acacacacag acacacacca agtaccagta taagcatctc     1140

ccatctgctt ttcccattgc catgcgtcct ggtcaggctt ccctcactct gtttcctggt     1200

cagcatgtac tcccctcatc cgattcccct gtagcagtca ctgacagtaa ataaaccttt     1260

gcaaacgttc                                                            1270


<210> 25
<211> 188
<212> PRT
<213> Homo sapiens

<400> 25
Met Asn Gly Asp Asp Thr Phe Ala Arg Arg Pro Thr Val Gly Ala Gln 
1               5                   10                  15      


Ile Pro Glu Lys Ile Gln Lys Ala Phe Asp Asp Ile Ala Lys Tyr Phe 
            20                  25                  30          


Ser Lys Glu Glu Trp Glu Lys Met Lys Val Ser Glu Lys Ile Val Tyr 
        35                  40                  45              


Val Tyr Met Lys Arg Lys Tyr Glu Ala Met Thr Lys Leu Gly Phe Lys 
    50                  55                  60                  


Ala Ile Leu Pro Ser Phe Met Arg Asn Lys Arg Val Thr Asp Phe Gln 
65                  70                  75                  80  


Gly Asn Asp Phe Asp Asn Asp Pro Asn Arg Gly Asn Gln Val Gln Arg 
                85                  90                  95      


Pro Gln Met Thr Phe Gly Arg Leu Gln Gly Ile Phe Pro Lys Ile Met 
            100                 105                 110         


Pro Lys Lys Pro Ala Glu Glu Gly Asn Val Ser Lys Glu Val Pro Glu 
        115                 120                 125             


Ala Ser Gly Pro Gln Asn Asp Gly Lys Gln Leu Cys Pro Pro Gly Lys 
    130                 135                 140                 


Pro Thr Thr Ser Glu Lys Ile Asn Met Ile Ser Gly Pro Lys Arg Gly 
145                 150                 155                 160 


Glu His Ala Trp Thr His Arg Leu Arg Glu Arg Lys Gln Leu Val Ile 
                165                 170                 175     


Tyr Glu Glu Ile Ser Asp Pro Glu Glu Asp Asp Glu 
            180                 185             


<210> 26
<211> 1416
<212> DNA
<213> Homo sapiens

<400> 26
ctctctctct cgatttttcc acagagtacg cacgctctga ttgtttcgat tcttccaaaa       60

tcagagacag agtgctcccg gtgccatgaa cggagacgat gcctttgtac ggagacctag      120

ggttggttct caaataccag agaagatgca aaagcatccc tggagacaag tctgtgaccg      180

tggaatacat ttggtgaatc tcagtccgtt ctggaaggtg ggaagagagc cagccagcag      240

cattaaagct ctactgtgtg gcaggggaga agctagggcc ttcgatgata ttgccaaata      300

cttctctgag aaagagtggg aaaagatgaa agcctcggag aaaatcatct atgtgtatat      360

gaagagaaag tatgaggcca tgactaaact aggtttcaag gccaccctcc cacctttcat      420

gcgtaataaa cgggtcgcag acttccaggg gaatgatttt gataatgacc ctaaccgtgg      480

gaatcaggtt gaacatcctc agatgacttt cggcaggctc cagggaatct tcccgaagat      540

cacgcccgag aagccagcag aggaaggaaa tgattcgaag ggagtgccag aagcatctgg      600

cccacagaac aatgggaaac agctgcgccc ctcaggaaaa ctaaatacct ctgagaaggt      660

taacaagaca tctggaccca aaagggggaa acatgcctgg acccacagag tgcgtgagag      720

aaagcaactg gtgatttatg aagagatcag cgaccctcag gaagatgacg agtaactccc      780

ctcggggata tgacacatgc ccatgatgag aagcagaacg tggtgacctt tcacgaacat      840

gggcatggct gcggatccct cgtcatcagg tgtatagcaa gtgaaagcaa gtgttcacaa      900

cagtgaaaag ttgagcgtca tttttcttag tgtgccaaga gttcgatgtt agtgtttctg      960

ttgtattttg ttacagtgtg ccattctgtt agatattagc gttttcactg atgagcaaga     1020

catacttaat gcatatttca gtttgtgtat ccatgcacct acctcagaaa acaagtatcg     1080

tcaggtattc tctgcataga acaacactac cctcctctct tcccagatgt gaccactgag     1140

ggcagttctg agtgtttaat ttcagatttt ttcctctgca tttacacaaa cacacacaca     1200

tgccacacag acacacatgc gcgcgcgcgc gcacacacac acacacacac acacacacac     1260

acacacacac caagtaccag tataggcatc tcccaactgc ttttccccat gtgtcctggt     1320

caagcccccc tcactctgtt tcctgttcag catgtactcc cctcatccga ttcccctcta     1380

tcagtcactg ccagttaata aacctttgca aacgtt                               1416


<210> 27
<211> 229
<212> PRT
<213> Homo sapiens

<400> 27
Met Asn Gly Asp Asp Ala Phe Val Arg Arg Pro Arg Val Gly Ser Gln 
1               5                   10                  15      


Ile Pro Glu Lys Met Gln Lys His Pro Trp Arg Gln Val Cys Asp Arg 
            20                  25                  30          


Gly Ile His Leu Val Asn Leu Ser Pro Phe Trp Lys Val Gly Arg Glu 
        35                  40                  45              


Pro Ala Ser Ser Ile Lys Ala Leu Leu Cys Gly Arg Gly Glu Ala Arg 
    50                  55                  60                  


Ala Phe Asp Asp Ile Ala Lys Tyr Phe Ser Glu Lys Glu Trp Glu Lys 
65                  70                  75                  80  


Met Lys Ala Ser Glu Lys Ile Ile Tyr Val Tyr Met Lys Arg Lys Tyr 
                85                  90                  95      


Glu Ala Met Thr Lys Leu Gly Phe Lys Ala Thr Leu Pro Pro Phe Met 
            100                 105                 110         


Arg Asn Lys Arg Val Ala Asp Phe Gln Gly Asn Asp Phe Asp Asn Asp 
        115                 120                 125             


Pro Asn Arg Gly Asn Gln Val Glu His Pro Gln Met Thr Phe Gly Arg 
    130                 135                 140                 


Leu Gln Gly Ile Phe Pro Lys Ile Thr Pro Glu Lys Pro Ala Glu Glu 
145                 150                 155                 160 


Gly Asn Asp Ser Lys Gly Val Pro Glu Ala Ser Gly Pro Gln Asn Asn 
                165                 170                 175     


Gly Lys Gln Leu Arg Pro Ser Gly Lys Leu Asn Thr Ser Glu Lys Val 
            180                 185                 190         


Asn Lys Thr Ser Gly Pro Lys Arg Gly Lys His Ala Trp Thr His Arg 
        195                 200                 205             


Val Arg Glu Arg Lys Gln Leu Val Ile Tyr Glu Glu Ile Ser Asp Pro 
    210                 215                 220                 


Gln Glu Asp Asp Glu 
225                 


<210> 28
<211> 1276
<212> DNA
<213> Homo sapiens

<400> 28
cgctctgatt gtttcgattc ttccaaaatc agagacagag tgctcccggt gccatgaacg       60

gagacgatgc ctttgtacgg agacctaggg ttggttctca aataccagag aagatgcaaa      120

aggccttcga tgatattgcc aaatacttct ctgagaaaga gtgggaaaag atgaaagcct      180

cggagaaaat catctatgtg tatatgaaga gaaagtatga ggccatgact aaactaggtt      240

tcaaggccac cctcccacct ttcatgcgta ataaacgggt cgcagacttc caggggaatg      300

attttgataa tgaccctaac cgtgggaatc aggttgaaca tcctcagatg actttcggca      360

ggctccaggg aatcttcccg aagatcacgc ccgagaagcc agcagaggaa ggaaatgatt      420

cgaagggagt gccagaagca tctggcccac agaacaatgg gaaacagctg cgcccctcag      480

gaaaactaaa tacctctgag aaggttaaca agacatctgg acccaaaagg gggaaacatg      540

cctggaccca cagagtgcgt gagagaaagc aactggtgat ttatgaagag atcagcgacc      600

ctcaggaaga tgacgagtaa ctcccctcgg ggatatgaca catgcccatg atgagaagca      660

gaacgtggtg acctttcacg aacatgggca tggctgcgga tccctcgtca tcaggtgtat      720

agcaagtgaa agcaagtgtt cacaacagtg aaaagttgag cgtcattttt cttagtgtgc      780

caagagttcg atgttagtgt ttctgttgta ttttgttaca gtgtgccatt ctgttagata      840

ttagcgtttt cactgatgag caagacatac ttaatgcata tttcagtttg tgtatccatg      900

cacctacctc agaaaacaag tatcgtcagg tattctctgc atagaacaac actaccctcc      960

tctcttccca gatgtgacca ctgagggcag ttctgagtgt ttaatttcag attttttcct     1020

ctgcatttac acaaacacac acacatgcca cacagacaca catgcgcgcg cgcgcgcaca     1080

cacacacaca cacacacaca cacacacaca cacaccaagt accagtatag gcatctccca     1140

actgcttttc cccatgtgtc ctggtcaagc ccccctcact ctgtttcctg ttcagcatgt     1200

actcccctca tccgattccc ctctatcagt cactgccagt taataaacct ttgcaaacgt     1260

taaaaaaaaa aaaaaa                                                     1276


<210> 29
<211> 188
<212> PRT
<213> Homo sapiens

<400> 29
Met Asn Gly Asp Asp Ala Phe Val Arg Arg Pro Arg Val Gly Ser Gln 
1               5                   10                  15      


Ile Pro Glu Lys Met Gln Lys Ala Phe Asp Asp Ile Ala Lys Tyr Phe 
            20                  25                  30          


Ser Glu Lys Glu Trp Glu Lys Met Lys Ala Ser Glu Lys Ile Ile Tyr 
        35                  40                  45              


Val Tyr Met Lys Arg Lys Tyr Glu Ala Met Thr Lys Leu Gly Phe Lys 
    50                  55                  60                  


Ala Thr Leu Pro Pro Phe Met Arg Asn Lys Arg Val Ala Asp Phe Gln 
65                  70                  75                  80  


Gly Asn Asp Phe Asp Asn Asp Pro Asn Arg Gly Asn Gln Val Glu His 
                85                  90                  95      


Pro Gln Met Thr Phe Gly Arg Leu Gln Gly Ile Phe Pro Lys Ile Thr 
            100                 105                 110         


Pro Glu Lys Pro Ala Glu Glu Gly Asn Asp Ser Lys Gly Val Pro Glu 
        115                 120                 125             


Ala Ser Gly Pro Gln Asn Asn Gly Lys Gln Leu Arg Pro Ser Gly Lys 
    130                 135                 140                 


Leu Asn Thr Ser Glu Lys Val Asn Lys Thr Ser Gly Pro Lys Arg Gly 
145                 150                 155                 160 


Lys His Ala Trp Thr His Arg Val Arg Glu Arg Lys Gln Leu Val Ile 
                165                 170                 175     


Tyr Glu Glu Ile Ser Asp Pro Gln Glu Asp Asp Glu 
            180                 185             


<210> 30
<211> 1340
<212> DNA
<213> Homo sapiens

<400> 30
ccaggctcca gggacagaac cttctcaaag tgggggtgga gactctgatt ttcccgccta       60

aagcatcccc tgggattggc tactttaagt tcagagtatg catgctctga ctttctctct      120

cgattcttcc atactcagag tcagactgct cctggtgcca tgaacggaga cgacgccttt      180

gcaaggagac ctagggctgg tgctcaaata ccagagaaga tccaaaagtc cttcgatgat      240

attgccaaat acttctctaa gaaagagtgg gaaaagatga aatccttgga gaaaatcagc      300

tatgtgtata tgaagagaaa gtatgaggcc atgactaaac taggcttcaa ggccaccctc      360

ccacctttca tgcataatac aggggccaca gacctccagg ggaatgattt tgataatgac      420

cgtaaccaag ggaatcaggt tgaacgtcct cagatgactt tttgcaggct ccagagaatc      480

ttcccgaaga tcatgcccaa gaagccagca gaggaaggaa atgattcgaa gggagtgcca      540

gaagcatctg gctcacagaa cgatgggaaa cacctgtgcc ctccaggaaa accaagtacc      600

tctgagaaga ttaacaagac atccggaccc aaaaggggga aacatgcctg gacccacaga      660

ctgcgtgaga gaaagcagct ggtgatttat gaagagatca gcgaccctga agaagacgac      720

gagtaactcc cctcggggat acgacatatg cccatgatga gaagcagaac gtggtgacct      780

ttcacgaaca tgggcatggc tgcggacccc tcgtcatcag gtgcatagca agtgaaagca      840

agtgttcaca acagtgaaaa gttgagcgtc gtttttctta gtgtgacaag agttcgatgt      900

tagtgtttcc attgtatttt cttacagtgt gccattctgt tagatattag cgttttcatt      960

gatgagcaag acatgcttaa tgtgtatttc ggtttgtgta tccatgcacc tacctcagaa     1020

agcaagtata gtcaggtatt ctctccatag aacagcacta ccctcctctc tccccagatg     1080

tgactactga gggcagatct gagtgtttaa tttccgattt tcccctctgc atttacacac     1140

cagacacaca aacacacaca cacagacaca cacacacaca gacacaccaa gtaccagtat     1200

aagcatctcc catatgcttt tccccattgc catgagtcct ggtcaagccc cccttcaatt     1260

tgtttcctgt tcagcatgta ctcccctcct ctgattcccc gtatcagtca ctgacagtta     1320

atacaccttt gcaaacgttc                                                 1340


<210> 31
<211> 188
<212> PRT
<213> Homo sapiens

<400> 31
Met Asn Gly Asp Asp Ala Phe Ala Arg Arg Pro Arg Ala Gly Ala Gln 
1               5                   10                  15      


Ile Pro Glu Lys Ile Gln Lys Ser Phe Asp Asp Ile Ala Lys Tyr Phe 
            20                  25                  30          


Ser Lys Lys Glu Trp Glu Lys Met Lys Ser Leu Glu Lys Ile Ser Tyr 
        35                  40                  45              


Val Tyr Met Lys Arg Lys Tyr Glu Ala Met Thr Lys Leu Gly Phe Lys 
    50                  55                  60                  


Ala Thr Leu Pro Pro Phe Met His Asn Thr Gly Ala Thr Asp Leu Gln 
65                  70                  75                  80  


Gly Asn Asp Phe Asp Asn Asp Arg Asn Gln Gly Asn Gln Val Glu Arg 
                85                  90                  95      


Pro Gln Met Thr Phe Cys Arg Leu Gln Arg Ile Phe Pro Lys Ile Met 
            100                 105                 110         


Pro Lys Lys Pro Ala Glu Glu Gly Asn Asp Ser Lys Gly Val Pro Glu 
        115                 120                 125             


Ala Ser Gly Ser Gln Asn Asp Gly Lys His Leu Cys Pro Pro Gly Lys 
    130                 135                 140                 


Pro Ser Thr Ser Glu Lys Ile Asn Lys Thr Ser Gly Pro Lys Arg Gly 
145                 150                 155                 160 


Lys His Ala Trp Thr His Arg Leu Arg Glu Arg Lys Gln Leu Val Ile 
                165                 170                 175     


Tyr Glu Glu Ile Ser Asp Pro Glu Glu Asp Asp Glu 
            180                 185             


<210> 32
<211> 3440
<212> DNA
<213> Homo sapiens

<400> 32
gagaggccgg cgtctctccc ccagtttgcc gttcacccgg agcgctcggg acttgccgat       60

agtggtgacg gcggcaacat gtctgtggct ttcgcggccc cgaggcagcg aggcaagggg      120

gagatcactc ccgctgcgat tcagaagatg ttggatgaca ataaccatct tattcagtgt      180

ataatggact ctcagaataa aggaaagacc tcagagtgtt ctcagtatca gcagatgttg      240

cacacaaact tggtatacct tgctacaata gcagattcta atcaaaatat gcagtctctt      300

ttaccagcac cacccacaca gaatatgcct atgggtcctg gagggatgaa tcagagcggc      360

cctcccccac ctccacgctc tcacaacatg ccttcagatg gaatggtagg tgggggtcct      420

cctgcaccgc acatgcagaa ccagatgaac ggccagatgc ctgggcctaa ccatatgcct      480

atgcagggac ctggacccaa tcaactcaat atgacaaaca gttccatgaa tatgccttca      540

agtagccatg gatccatggg aggttacaac cattctgtgc catcatcaca gagcatgcca      600

gtacagaatc agatgacaat gagtcaggga caaccaatgg gaaactatgg tcccagacca      660

aatatgagta tgcagccaaa ccaaggtcca atgatgcatc agcagcctcc ttctcagcaa      720

tacaatatgc cacagggagg cggacagcat taccaaggac agcagccacc tatgggaatg      780

atgggtcaag ttaaccaagg caatcatatg atgggtcaga gacagattcc tccctataga      840

cctcctcaac agggcccacc acagcagtac tcaggccagg aagactatta cggggaccaa      900

tacagtcatg gtggacaagg tcctccagaa ggcatgaacc agcaatatta ccctgatggt      960

cataatgatt acggttatca gcaaccgtcg tatcctgaac aaggctacga taggccttat     1020

gaggattcct cacaacatta ctacgaagga ggaaattcac agtatggcca acagcaagat     1080

gcataccagg gaccacctcc acaacaggga tatccacccc agcagcagca gtacccaggg     1140

cagcaaggtt acccaggaca gcagcagggc tacggtcctt cacagggtgg tccaggtcct     1200

cagtatccta actacccaca gggacaaggt cagcagtatg gaggatatag accaacacag     1260

cctggaccac cacagccacc ccagcagagg ccttatggat atgaccaggg acagtatgga     1320

aattaccagc agtgaaaaag tacttacatt ccagtagcca gtatctatta gcagccatat     1380

tgtcacctca gcactgtgga cacctccctg tgaagagatc cttccattcc atctagtttt     1440

tggaaaaacc ttgtggataa gtggctgttt catcagtaag cagcctttgt ggtttagtta     1500

taaaaggctt tagtagctca aaaatactct tgatttcaca tttctactct agatggcaac     1560

attggacaga aaatgcaatg acataaccaa tttgtaatga ttttggaact gtgtttcaaa     1620

tggactgtta cagactgaaa ggtgtgaaca gctttgtatg tttatgaagg gtaagggaat     1680

ttaatacttt tccacagatt tttttgtaag gggaagaggg aaatgtacac tttttacagc     1740

agcaatattt tgtatattat gtttatttca tgtggtgaat atgcaaggcg gtacactacg     1800

cactggacag catcagaaat cctctgttaa tgtggactgg aacatggtag atgcttgatt     1860

gttttggtct caaaatggtg tgctataaag ataaaggtga ggggaagaca aagcacacca     1920

tatgtccact gttctgttct catagaggaa attcaaatcc cttttatcta ttagataatc     1980

aagggcactg tgatacagtt ttgagtaaaa agacattttt taaaagcctt ccagttttgt     2040

ggattaaacc tttttataaa gatcatttat aatactgttt taaaatgtga ggcaataaga     2100

attactttgt gttggatctg aggaggcttt ggtaaaacag tttcatctaa atgaaagtgg     2160

taatcctctt ctaaaatagc aataactgaa aatgaaagtg ttaattttac cttgtttgag     2220

ttatcaggga acttagtaag taatatcaaa gcattttata aatgatatca aagaagagtc     2280

aacattgatc cagtcatttt attttgtaat attgagggat aattggttat taaactgaat     2340

agttcaggag actttacaaa cctttgtttc aactttctta tctggaaata atatcattta     2400

taaagggaca cttttatgtt tttccctttt ttatgttggt tgatataaca caaagagata     2460

tttaggaaaa tgcttattga tgaggtttat tctatctgtt tttaaagcac cgaggttgca     2520

ttctagataa ccttgtttat tagcatggca tattttaatc attatttgag actgtcctgt     2580

gcctgattat tttagctaaa ttcagggaga ttgcgtgggg caggaaagca tgcattgaaa     2640

aatttctaac cacggttatt taagcataat ctgaaaacat ctagcccaaa ggtaagttgc     2700

tattttcatc acagttgcct atgcccaggg aataagatgt attctttata attgaattgg     2760

tttttcccac gtctaactgg aaacaaaaca gaaggggcgt cataaatttg aataagcaga     2820

acatactgtt ctcaacatac tgtaatcaaa aggaggaatt tcagtgggtc tctgtgtgtg     2880

tatgagagag agagtgtgtg tttgtgtgtt tcaaggtcag aacaggtttt tttgtttttg     2940

ttttttgttc tttgtttttt tttttgagat ggagtcttgc tcttgtcgcc caggctggag     3000

tgcagtggcg caatctcagc tcactgcaac ctccgcctcc caggttcaag cagttctcct     3060

gcctcagcct cctgagtagc tgggatgaca ggcacccgcc accacaccca gctaattttt     3120

gtacttttag tagagacgag gtttcgccat gttggccagg ctggtctcga actcctgacc     3180

tcaggtgatc cacccgcctc ggccttccaa agtgctggga ttacaggcgt gagccaccgt     3240

gcctggccag aataggtttt ttctttcaac ttgatcagta gaaaatggac atcaagtttg     3300

aacagataaa tcatggacag ccttattgtg attgaaatgc ttgtaggttc tgtgccaatt     3360

ttccaccact gtgtactttg ttgctattta aaactgtatc aactctaacg gaagaataaa     3420

ttatttgtga ttttaaaaaa                                                 3440


<210> 33
<211> 418
<212> PRT
<213> Homo sapiens

<400> 33
Met Ser Val Ala Phe Ala Ala Pro Arg Gln Arg Gly Lys Gly Glu Ile 
1               5                   10                  15      


Thr Pro Ala Ala Ile Gln Lys Met Leu Asp Asp Asn Asn His Leu Ile 
            20                  25                  30          


Gln Cys Ile Met Asp Ser Gln Asn Lys Gly Lys Thr Ser Glu Cys Ser 
        35                  40                  45              


Gln Tyr Gln Gln Met Leu His Thr Asn Leu Val Tyr Leu Ala Thr Ile 
    50                  55                  60                  


Ala Asp Ser Asn Gln Asn Met Gln Ser Leu Leu Pro Ala Pro Pro Thr 
65                  70                  75                  80  


Gln Asn Met Pro Met Gly Pro Gly Gly Met Asn Gln Ser Gly Pro Pro 
                85                  90                  95      


Pro Pro Pro Arg Ser His Asn Met Pro Ser Asp Gly Met Val Gly Gly 
            100                 105                 110         


Gly Pro Pro Ala Pro His Met Gln Asn Gln Met Asn Gly Gln Met Pro 
        115                 120                 125             


Gly Pro Asn His Met Pro Met Gln Gly Pro Gly Pro Asn Gln Leu Asn 
    130                 135                 140                 


Met Thr Asn Ser Ser Met Asn Met Pro Ser Ser Ser His Gly Ser Met 
145                 150                 155                 160 


Gly Gly Tyr Asn His Ser Val Pro Ser Ser Gln Ser Met Pro Val Gln 
                165                 170                 175     


Asn Gln Met Thr Met Ser Gln Gly Gln Pro Met Gly Asn Tyr Gly Pro 
            180                 185                 190         


Arg Pro Asn Met Ser Met Gln Pro Asn Gln Gly Pro Met Met His Gln 
        195                 200                 205             


Gln Pro Pro Ser Gln Gln Tyr Asn Met Pro Gln Gly Gly Gly Gln His 
    210                 215                 220                 


Tyr Gln Gly Gln Gln Pro Pro Met Gly Met Met Gly Gln Val Asn Gln 
225                 230                 235                 240 


Gly Asn His Met Met Gly Gln Arg Gln Ile Pro Pro Tyr Arg Pro Pro 
                245                 250                 255     


Gln Gln Gly Pro Pro Gln Gln Tyr Ser Gly Gln Glu Asp Tyr Tyr Gly 
            260                 265                 270         


Asp Gln Tyr Ser His Gly Gly Gln Gly Pro Pro Glu Gly Met Asn Gln 
        275                 280                 285             


Gln Tyr Tyr Pro Asp Gly His Asn Asp Tyr Gly Tyr Gln Gln Pro Ser 
    290                 295                 300                 


Tyr Pro Glu Gln Gly Tyr Asp Arg Pro Tyr Glu Asp Ser Ser Gln His 
305                 310                 315                 320 


Tyr Tyr Glu Gly Gly Asn Ser Gln Tyr Gly Gln Gln Gln Asp Ala Tyr 
                325                 330                 335     


Gln Gly Pro Pro Pro Gln Gln Gly Tyr Pro Pro Gln Gln Gln Gln Tyr 
            340                 345                 350         


Pro Gly Gln Gln Gly Tyr Pro Gly Gln Gln Gln Gly Tyr Gly Pro Ser 
        355                 360                 365             


Gln Gly Gly Pro Gly Pro Gln Tyr Pro Asn Tyr Pro Gln Gly Gln Gly 
    370                 375                 380                 


Gln Gln Tyr Gly Gly Tyr Arg Pro Thr Gln Pro Gly Pro Pro Gln Pro 
385                 390                 395                 400 


Pro Gln Gln Arg Pro Tyr Gly Tyr Asp Gln Gly Gln Tyr Gly Asn Tyr 
                405                 410                 415     


Gln Gln 
        


<210> 34
<211> 3347
<212> DNA
<213> Homo sapiens

<400> 34
gagaggccgg cgtctctccc ccagtttgcc gttcacccgg agcgctcggg acttgccgat       60

agtggtgacg gcggcaacat gtctgtggct ttcgcggccc cgaggcagcg aggcaagggg      120

gagatcactc ccgctgcgat tcagaagatg ttggatgaca ataaccatct tattcagtgt      180

ataatggact ctcagaataa aggaaagacc tcagagtgtt ctcagtatca gcagatgttg      240

cacacaaact tggtatacct tgctacaata gcagattcta atcaaaatat gcagtctctt      300

ttaccagcac cacccacaca gaatatgcct atgggtcctg gagggatgaa tcagagcggc      360

cctcccccac ctccacgctc tcacaacatg ccttcagatg gaatggtagg tgggggtcct      420

cctgcaccgc acatgcagaa ccagatgaac ggccagatgc ctgggcctaa ccatatgcct      480

atgcagggac ctggacccaa tcaactcaat atgacaaaca gttccatgaa tatgccttca      540

agtagccatg gatccatggg aggttacaac cattctgtgc catcatcaca gagcatgcca      600

gtacagaatc agatgacaat gagtcaggga caaccaatgg gaaactatgg tcccagacca      660

aatatgagta tgcagccaaa ccaaggtcca atgatgcatc agcagcctcc ttctcagcaa      720

tacaatatgc cacagggagg cggacagcat taccaaggac agcagccacc tatgggaatg      780

atgggtcaag ttaaccaagg caatcatatg atgggtcaga gacagattcc tccctataga      840

cctcctcaac agggcccacc acagcagtac tcaggccagg aagactatta cggggaccaa      900

tacagtcatg gtggacaagg tcctccagaa ggcatgaacc agcaatatta ccctgatgga      960

aattcacagt atggccaaca gcaagatgca taccagggac cacctccaca acagggatat     1020

ccaccccagc agcagcagta cccagggcag caaggttacc caggacagca gcagggctac     1080

ggtccttcac agggtggtcc aggtcctcag tatcctaact acccacaggg acaaggtcag     1140

cagtatggag gatatagacc aacacagcct ggaccaccac agccacccca gcagaggcct     1200

tatggatatg accagggaca gtatggaaat taccagcagt gaaaaagtac ttacattcca     1260

gtagccagta tctattagca gccatattgt cacctcagca ctgtggacac ctccctgtga     1320

agagatcctt ccattccatc tagtttttgg aaaaaccttg tggataagtg gctgtttcat     1380

cagtaagcag cctttgtggt ttagttataa aaggctttag tagctcaaaa atactcttga     1440

tttcacattt ctactctaga tggcaacatt ggacagaaaa tgcaatgaca taaccaattt     1500

gtaatgattt tggaactgtg tttcaaatgg actgttacag actgaaaggt gtgaacagct     1560

ttgtatgttt atgaagggta agggaattta atacttttcc acagattttt ttgtaagggg     1620

aagagggaaa tgtacacttt ttacagcagc aatattttgt atattatgtt tatttcatgt     1680

ggtgaatatg caaggcggta cactacgcac tggacagcat cagaaatcct ctgttaatgt     1740

ggactggaac atggtagatg cttgattgtt ttggtctcaa aatggtgtgc tataaagata     1800

aaggtgaggg gaagacaaag cacaccatat gtccactgtt ctgttctcat agaggaaatt     1860

caaatccctt ttatctatta gataatcaag ggcactgtga tacagttttg agtaaaaaga     1920

cattttttaa aagccttcca gttttgtgga ttaaaccttt ttataaagat catttataat     1980

actgttttaa aatgtgaggc aataagaatt actttgtgtt ggatctgagg aggctttggt     2040

aaaacagttt catctaaatg aaagtggtaa tcctcttcta aaatagcaat aactgaaaat     2100

gaaagtgtta attttacctt gtttgagtta tcagggaact tagtaagtaa tatcaaagca     2160

ttttataaat gatatcaaag aagagtcaac attgatccag tcattttatt ttgtaatatt     2220

gagggataat tggttattaa actgaatagt tcaggagact ttacaaacct ttgtttcaac     2280

tttcttatct ggaaataata tcatttataa agggacactt ttatgttttt ccctttttta     2340

tgttggttga tataacacaa agagatattt aggaaaatgc ttattgatga ggtttattct     2400

atctgttttt aaagcaccga ggttgcattc tagataacct tgtttattag catggcatat     2460

tttaatcatt atttgagact gtcctgtgcc tgattatttt agctaaattc agggagattg     2520

cgtggggcag gaaagcatgc attgaaaaat ttctaaccac ggttatttaa gcataatctg     2580

aaaacatcta gcccaaaggt aagttgctat tttcatcaca gttgcctatg cccagggaat     2640

aagatgtatt ctttataatt gaattggttt ttcccacgtc taactggaaa caaaacagaa     2700

ggggcgtcat aaatttgaat aagcagaaca tactgttctc aacatactgt aatcaaaagg     2760

aggaatttca gtgggtctct gtgtgtgtat gagagagaga gtgtgtgttt gtgtgtttca     2820

aggtcagaac aggttttttt gtttttgttt tttgttcttt gttttttttt ttgagatgga     2880

gtcttgctct tgtcgcccag gctggagtgc agtggcgcaa tctcagctca ctgcaacctc     2940

cgcctcccag gttcaagcag ttctcctgcc tcagcctcct gagtagctgg gatgacaggc     3000

acccgccacc acacccagct aatttttgta cttttagtag agacgaggtt tcgccatgtt     3060

ggccaggctg gtctcgaact cctgacctca ggtgatccac ccgcctcggc cttccaaagt     3120

gctgggatta caggcgtgag ccaccgtgcc tggccagaat aggttttttc tttcaacttg     3180

atcagtagaa aatggacatc aagtttgaac agataaatca tggacagcct tattgtgatt     3240

gaaatgcttg taggttctgt gccaattttc caccactgtg tactttgttg ctatttaaaa     3300

ctgtatcaac tctaacggaa gaataaatta tttgtgattt taaaaaa                   3347


<210> 35
<211> 387
<212> PRT
<213> Homo sapiens

<400> 35
Met Ser Val Ala Phe Ala Ala Pro Arg Gln Arg Gly Lys Gly Glu Ile 
1               5                   10                  15      


Thr Pro Ala Ala Ile Gln Lys Met Leu Asp Asp Asn Asn His Leu Ile 
            20                  25                  30          


Gln Cys Ile Met Asp Ser Gln Asn Lys Gly Lys Thr Ser Glu Cys Ser 
        35                  40                  45              


Gln Tyr Gln Gln Met Leu His Thr Asn Leu Val Tyr Leu Ala Thr Ile 
    50                  55                  60                  


Ala Asp Ser Asn Gln Asn Met Gln Ser Leu Leu Pro Ala Pro Pro Thr 
65                  70                  75                  80  


Gln Asn Met Pro Met Gly Pro Gly Gly Met Asn Gln Ser Gly Pro Pro 
                85                  90                  95      


Pro Pro Pro Arg Ser His Asn Met Pro Ser Asp Gly Met Val Gly Gly 
            100                 105                 110         


Gly Pro Pro Ala Pro His Met Gln Asn Gln Met Asn Gly Gln Met Pro 
        115                 120                 125             


Gly Pro Asn His Met Pro Met Gln Gly Pro Gly Pro Asn Gln Leu Asn 
    130                 135                 140                 


Met Thr Asn Ser Ser Met Asn Met Pro Ser Ser Ser His Gly Ser Met 
145                 150                 155                 160 


Gly Gly Tyr Asn His Ser Val Pro Ser Ser Gln Ser Met Pro Val Gln 
                165                 170                 175     


Asn Gln Met Thr Met Ser Gln Gly Gln Pro Met Gly Asn Tyr Gly Pro 
            180                 185                 190         


Arg Pro Asn Met Ser Met Gln Pro Asn Gln Gly Pro Met Met His Gln 
        195                 200                 205             


Gln Pro Pro Ser Gln Gln Tyr Asn Met Pro Gln Gly Gly Gly Gln His 
    210                 215                 220                 


Tyr Gln Gly Gln Gln Pro Pro Met Gly Met Met Gly Gln Val Asn Gln 
225                 230                 235                 240 


Gly Asn His Met Met Gly Gln Arg Gln Ile Pro Pro Tyr Arg Pro Pro 
                245                 250                 255     


Gln Gln Gly Pro Pro Gln Gln Tyr Ser Gly Gln Glu Asp Tyr Tyr Gly 
            260                 265                 270         


Asp Gln Tyr Ser His Gly Gly Gln Gly Pro Pro Glu Gly Met Asn Gln 
        275                 280                 285             


Gln Tyr Tyr Pro Asp Gly Asn Ser Gln Tyr Gly Gln Gln Gln Asp Ala 
    290                 295                 300                 


Tyr Gln Gly Pro Pro Pro Gln Gln Gly Tyr Pro Pro Gln Gln Gln Gln 
305                 310                 315                 320 


Tyr Pro Gly Gln Gln Gly Tyr Pro Gly Gln Gln Gln Gly Tyr Gly Pro 
                325                 330                 335     


Ser Gln Gly Gly Pro Gly Pro Gln Tyr Pro Asn Tyr Pro Gln Gly Gln 
            340                 345                 350         


Gly Gln Gln Tyr Gly Gly Tyr Arg Pro Thr Gln Pro Gly Pro Pro Gln 
        355                 360                 365             


Pro Pro Gln Gln Arg Pro Tyr Gly Tyr Asp Gln Gly Gln Tyr Gly Asn 
    370                 375                 380                 


Tyr Gln Gln 
385         


<210> 36
<211> 3415
<212> DNA
<213> Homo sapiens

<400> 36
ccttccacct ctgccctatc tcggcagatg ctccacggat ttgcacgaac tcccgagtct       60

tgacctccct cccctctccg ggctgccggg acaactcggg gcggccactc ttgccaggag      120

gcatgttgga tgacaataac catcttattc agtgtataat ggactctcag aataaaggaa      180

agacctcaga gtgttctcag tatcagcaga tgttgcacac aaacttggta taccttgcta      240

caatagcaga ttctaatcaa aatatgcagt ctcttttacc agcaccaccc acacagaata      300

tgcctatggg tcctggaggg atgaatcaga gcggccctcc cccacctcca cgctctcaca      360

acatgccttc agatggaatg gtaggtgggg gtcctcctgc accgcacatg cagaaccaga      420

tgaacggcca gatgcctggg cctaaccata tgcctatgca gggacctgga cccaatcaac      480

tcaatatgac aaacagttcc atgaatatgc cttcaagtag ccatggatcc atgggaggtt      540

acaaccattc tgtgccatca tcacagagca tgccagtaca gaatcagatg acaatgagtc      600

agggacaacc aatgggaaac tatggtccca gaccaaatat gagtatgcag ccaaaccaag      660

gtccaatgat gcatcagcag cctccttctc agcaatacaa tatgccacag ggaggcggac      720

agcattacca aggacagcag ccacctatgg gaatgatggg tcaagttaac caaggcaatc      780

atatgatggg tcagagacag attcctccct atagacctcc tcaacagggc ccaccacagc      840

agtactcagg ccaggaagac tattacgggg accaatacag tcatggtgga caaggtcctc      900

cagaaggcat gaaccagcaa tattaccctg atggtcataa tgattacggt tatcagcaac      960

cgtcgtatcc tgaacaaggc tacgataggc cttatgagga ttcctcacaa cattactacg     1020

aaggaggaaa ttcacagtat ggccaacagc aagatgcata ccagggacca cctccacaac     1080

agggatatcc accccagcag cagcagtacc cagggcagca aggttaccca ggacagcagc     1140

agggctacgg tccttcacag ggtggtccag gtcctcagta tcctaactac ccacagggac     1200

aaggtcagca gtatggagga tatagaccaa cacagcctgg accaccacag ccaccccagc     1260

agaggcctta tggatatgac cagggacagt atggaaatta ccagcagtga aaaagtactt     1320

acattccagt agccagtatc tattagcagc catattgtca cctcagcact gtggacacct     1380

ccctgtgaag agatccttcc attccatcta gtttttggaa aaaccttgtg gataagtggc     1440

tgtttcatca gtaagcagcc tttgtggttt agttataaaa ggctttagta gctcaaaaat     1500

actcttgatt tcacatttct actctagatg gcaacattgg acagaaaatg caatgacata     1560

accaatttgt aatgattttg gaactgtgtt tcaaatggac tgttacagac tgaaaggtgt     1620

gaacagcttt gtatgtttat gaagggtaag ggaatttaat acttttccac agattttttt     1680

gtaaggggaa gagggaaatg tacacttttt acagcagcaa tattttgtat attatgttta     1740

tttcatgtgg tgaatatgca aggcggtaca ctacgcactg gacagcatca gaaatcctct     1800

gttaatgtgg actggaacat ggtagatgct tgattgtttt ggtctcaaaa tggtgtgcta     1860

taaagataaa ggtgagggga agacaaagca caccatatgt ccactgttct gttctcatag     1920

aggaaattca aatccctttt atctattaga taatcaaggg cactgtgata cagttttgag     1980

taaaaagaca ttttttaaaa gccttccagt tttgtggatt aaaccttttt ataaagatca     2040

tttataatac tgttttaaaa tgtgaggcaa taagaattac tttgtgttgg atctgaggag     2100

gctttggtaa aacagtttca tctaaatgaa agtggtaatc ctcttctaaa atagcaataa     2160

ctgaaaatga aagtgttaat tttaccttgt ttgagttatc agggaactta gtaagtaata     2220

tcaaagcatt ttataaatga tatcaaagaa gagtcaacat tgatccagtc attttatttt     2280

gtaatattga gggataattg gttattaaac tgaatagttc aggagacttt acaaaccttt     2340

gtttcaactt tcttatctgg aaataatatc atttataaag ggacactttt atgtttttcc     2400

cttttttatg ttggttgata taacacaaag agatatttag gaaaatgctt attgatgagg     2460

tttattctat ctgtttttaa agcaccgagg ttgcattcta gataaccttg tttattagca     2520

tggcatattt taatcattat ttgagactgt cctgtgcctg attattttag ctaaattcag     2580

ggagattgcg tggggcagga aagcatgcat tgaaaaattt ctaaccacgg ttatttaagc     2640

ataatctgaa aacatctagc ccaaaggtaa gttgctattt tcatcacagt tgcctatgcc     2700

cagggaataa gatgtattct ttataattga attggttttt cccacgtcta actggaaaca     2760

aaacagaagg ggcgtcataa atttgaataa gcagaacata ctgttctcaa catactgtaa     2820

tcaaaaggag gaatttcagt gggtctctgt gtgtgtatga gagagagagt gtgtgtttgt     2880

gtgtttcaag gtcagaacag gtttttttgt ttttgttttt tgttctttgt tttttttttt     2940

gagatggagt cttgctcttg tcgcccaggc tggagtgcag tggcgcaatc tcagctcact     3000

gcaacctccg cctcccaggt tcaagcagtt ctcctgcctc agcctcctga gtagctggga     3060

tgacaggcac ccgccaccac acccagctaa tttttgtact tttagtagag acgaggtttc     3120

gccatgttgg ccaggctggt ctcgaactcc tgacctcagg tgatccaccc gcctcggcct     3180

tccaaagtgc tgggattaca ggcgtgagcc accgtgcctg gccagaatag gttttttctt     3240

tcaacttgat cagtagaaaa tggacatcaa gtttgaacag ataaatcatg gacagcctta     3300

ttgtgattga aatgcttgta ggttctgtgc caattttcca ccactgtgta ctttgttgct     3360

atttaaaact gtatcaactc taacggaaga ataaattatt tgtgatttta aaaaa          3415


<210> 37
<211> 395
<212> PRT
<213> Homo sapiens

<400> 37
Met Leu Asp Asp Asn Asn His Leu Ile Gln Cys Ile Met Asp Ser Gln 
1               5                   10                  15      


Asn Lys Gly Lys Thr Ser Glu Cys Ser Gln Tyr Gln Gln Met Leu His 
            20                  25                  30          


Thr Asn Leu Val Tyr Leu Ala Thr Ile Ala Asp Ser Asn Gln Asn Met 
        35                  40                  45              


Gln Ser Leu Leu Pro Ala Pro Pro Thr Gln Asn Met Pro Met Gly Pro 
    50                  55                  60                  


Gly Gly Met Asn Gln Ser Gly Pro Pro Pro Pro Pro Arg Ser His Asn 
65                  70                  75                  80  


Met Pro Ser Asp Gly Met Val Gly Gly Gly Pro Pro Ala Pro His Met 
                85                  90                  95      


Gln Asn Gln Met Asn Gly Gln Met Pro Gly Pro Asn His Met Pro Met 
            100                 105                 110         


Gln Gly Pro Gly Pro Asn Gln Leu Asn Met Thr Asn Ser Ser Met Asn 
        115                 120                 125             


Met Pro Ser Ser Ser His Gly Ser Met Gly Gly Tyr Asn His Ser Val 
    130                 135                 140                 


Pro Ser Ser Gln Ser Met Pro Val Gln Asn Gln Met Thr Met Ser Gln 
145                 150                 155                 160 


Gly Gln Pro Met Gly Asn Tyr Gly Pro Arg Pro Asn Met Ser Met Gln 
                165                 170                 175     


Pro Asn Gln Gly Pro Met Met His Gln Gln Pro Pro Ser Gln Gln Tyr 
            180                 185                 190         


Asn Met Pro Gln Gly Gly Gly Gln His Tyr Gln Gly Gln Gln Pro Pro 
        195                 200                 205             


Met Gly Met Met Gly Gln Val Asn Gln Gly Asn His Met Met Gly Gln 
    210                 215                 220                 


Arg Gln Ile Pro Pro Tyr Arg Pro Pro Gln Gln Gly Pro Pro Gln Gln 
225                 230                 235                 240 


Tyr Ser Gly Gln Glu Asp Tyr Tyr Gly Asp Gln Tyr Ser His Gly Gly 
                245                 250                 255     


Gln Gly Pro Pro Glu Gly Met Asn Gln Gln Tyr Tyr Pro Asp Gly His 
            260                 265                 270         


Asn Asp Tyr Gly Tyr Gln Gln Pro Ser Tyr Pro Glu Gln Gly Tyr Asp 
        275                 280                 285             


Arg Pro Tyr Glu Asp Ser Ser Gln His Tyr Tyr Glu Gly Gly Asn Ser 
    290                 295                 300                 


Gln Tyr Gly Gln Gln Gln Asp Ala Tyr Gln Gly Pro Pro Pro Gln Gln 
305                 310                 315                 320 


Gly Tyr Pro Pro Gln Gln Gln Gln Tyr Pro Gly Gln Gln Gly Tyr Pro 
                325                 330                 335     


Gly Gln Gln Gln Gly Tyr Gly Pro Ser Gln Gly Gly Pro Gly Pro Gln 
            340                 345                 350         


Tyr Pro Asn Tyr Pro Gln Gly Gln Gly Gln Gln Tyr Gly Gly Tyr Arg 
        355                 360                 365             


Pro Thr Gln Pro Gly Pro Pro Gln Pro Pro Gln Gln Arg Pro Tyr Gly 
    370                 375                 380                 


Tyr Asp Gln Gly Gln Tyr Gly Asn Tyr Gln Gln 
385                 390                 395 


<210> 38
<211> 418
<212> PRT
<213> Mus musculus

<400> 38
Met Ser Val Ala Phe Ala Ala Pro Arg Gln Arg Gly Lys Gly Glu Ile 
1               5                   10                  15      


Thr Pro Ala Ala Ile Gln Lys Met Leu Asp Glu Asn Asn His Leu Ile 
            20                  25                  30          


Gln Cys Ile Met Asp Tyr Gln Asn Lys Gly Lys Ala Ser Glu Cys Ser 
        35                  40                  45              


Gln Tyr Gln Gln Ile Leu His Thr Asn Leu Val Tyr Leu Ala Thr Ile 
    50                  55                  60                  


Ala Asp Ser Asn Gln Asn Met Gln Ser Leu Leu Pro Ala Pro Pro Thr 
65                  70                  75                  80  


Gln Thr Met Pro Met Gly Pro Gly Gly Met Ser Gln Ser Gly Pro Pro 
                85                  90                  95      


Pro Pro Pro Arg Ser His Asn Met Pro Ser Asp Gly Met Val Gly Gly 
            100                 105                 110         


Gly Pro Pro Ala Pro His Met Gln Asn Gln Met Asn Gly Gln Met Pro 
        115                 120                 125             


Gly Pro Asn His Met Pro Met Gln Gly Pro Gly Pro Ser Gln Leu Ser 
    130                 135                 140                 


Met Thr Asn Ser Ser Met Asn Met Pro Ser Ser Ser His Gly Ser Met 
145                 150                 155                 160 


Gly Gly Tyr Asn His Ser Val Pro Ser Ser Gln Ser Met Pro Val Gln 
                165                 170                 175     


Asn Gln Met Thr Met Ser Gln Gly Gln Pro Met Gly Asn Tyr Gly Pro 
            180                 185                 190         


Arg Pro Asn Met Asn Met Gln Pro Asn Gln Gly Pro Met Met His Gln 
        195                 200                 205             


Gln Pro Pro Ser Gln Gln Tyr Asn Met Pro Pro Gly Gly Ala Gln His 
    210                 215                 220                 


Tyr Gln Gly Gln Gln Ala Pro Met Gly Leu Met Gly Gln Val Asn Gln 
225                 230                 235                 240 


Gly Ser His Met Met Gly Gln Arg Gln Met Pro Pro Tyr Arg Pro Pro 
                245                 250                 255     


Gln Gln Gly Pro Pro Gln Gln Tyr Ser Gly Gln Glu Asp Tyr Tyr Gly 
            260                 265                 270         


Asp Gln Tyr Ser His Gly Gly Gln Gly Pro Pro Glu Gly Met Asn Gln 
        275                 280                 285             


Gln Tyr Tyr Pro Asp Gly His Asn Asp Tyr Gly Tyr Gln Gln Pro Ser 
    290                 295                 300                 


Tyr Pro Glu Gln Gly Tyr Asp Arg Pro Tyr Glu Asp Ser Ser Gln His 
305                 310                 315                 320 


Tyr Tyr Glu Gly Gly Asn Ser Gln Tyr Gly Gln Gln Gln Asp Ala Tyr 
                325                 330                 335     


Gln Gly Pro Pro Pro Gln Gln Gly Tyr Pro Pro Gln Gln Gln Gln Tyr 
            340                 345                 350         


Pro Gly Gln Gln Gly Tyr Pro Gly Gln Gln Gln Ser Tyr Gly Pro Ser 
        355                 360                 365             


Gln Gly Gly Pro Gly Pro Gln Tyr Pro Asn Tyr Pro Gln Gly Gln Gly 
    370                 375                 380                 


Gln Gln Tyr Gly Gly Tyr Arg Pro Thr Gln Pro Gly Pro Pro Gln Pro 
385                 390                 395                 400 


Pro Gln Gln Arg Pro Tyr Gly Tyr Asp Gln Gly Gln Tyr Gly Asn Tyr 
                405                 410                 415     


Gln Gln 
        


<210> 39
<211> 3110
<212> DNA
<213> Mus musculus

<400> 39
ccttgctggg agctgcggct cagcgttaag gccaagccgg ccagcgaggg acgcggcccg       60

ggagcatcct ccccccaccg cgcgccctaa ggtggaactg cccggaggcg ggcgtcgggc      120

ccccagctcc gcgggccctg gagcgctcgg gactcgctga tcgcgggctc ggcggcaaca      180

tgtctgtggc gttcgcagcc ccgaggcagc ggggcaaggg cgaaatcacg cccgccgcca      240

tccagaagat gctggatgaa aacaaccatc ttattcagtg tataatggac tatcagaaca      300

aagggaaggc ctcggagtgc tcgcagtatc agcagatatt gcatacaaac ctggtatacc      360

ttgctacaat agcagactct aatcaaaata tgcagtctct cttaccagca ccgcccacac      420

agactatgcc aatgggtcct ggagggatga gtcagagtgg ccctccaccc cctccccgct      480

ctcacaacat gccttcagat ggaatggtgg gtgggggccc tcctgcacca cacatgcaga      540

accagatgaa cggccagatg cctgggccta accatatgcc aatgcaggga cctggaccca      600

gtcagctcag catgacaaac agctccatga atatgccttc aagtagccat ggctccatgg      660

gaggttacaa ccattctgtg ccgtcatccc agagcatgcc cgtgcagaac cagatgacaa      720

tgagtcaggg gcagccaatg ggaaactatg gtcccagacc aaacatgaat atgcaaccaa      780

atcaagggcc gatgatgcac cagcagcctc cttctcagca gtacaatatg ccacctggag      840

gggcacagca ttaccaagga cagcaggcgc ccatggggct gatgggccaa gttaaccaag      900

gcagtcacat gatgggccag cgacagatgc ctccctacag acctccgcaa cagggcccac      960

cacagcagta ctcaggccag gaagactatt atggggacca atacagtcat ggtggacaag     1020

gtcctccaga aggcatgaac cagcaatatt accctgatgg tcataatgat tacggttatc     1080

agcaaccgtc gtatcctgaa caaggctacg ataggcctta tgaggattcc tcacaacatt     1140

actacgaagg aggaaactcc cagtatggcc aacagcaaga cgcttaccag ggaccacctc     1200

cacagcaagg atacccaccc cagcagcagc agtacccggg acagcaggga tacccagggc     1260

agcagcagag ctatggtcct tcgcagggcg gtccaggtcc tcagtatcct aattatcctc     1320

agggtcaagg tcagcagtat gggggctata gaccaacaca gccaggacca ccccagccac     1380

cccagcagag gccttatggg tacgaccagg gacagtatgg aaattaccag cagtgaaaat     1440

gtccttacat tccaatagcc agtacctatt agcaggcacg ttgtcacagc actgcaccat     1500

ggacaccccc ctgggaagac tccttccatt ccagctaggt ttttgggaaa acctttggct     1560

aagtggctgc ttcgtcagca agtagctgtt atggtttagt ttgtaaaggc ttcgtagcta     1620

ccgatgcacc tgatttcacg tttctactct agatggcaac attggacaga aaatgcattg     1680

acgtgaggag tttgcagcgg tttcagaact gtgctgcaaa tggactgtca cagcctgaaa     1740

ggtgtgagca gctgggtgtg tgttcgcgga gcttcagggg gtttcatact tttccaccga     1800

ttattttgta aggggaaggg ggaaatgtac actttttaca gcagcaatat tttgtctatt     1860

atgtttattt catgtgataa atatgcaaag cggtacacta cacactgggc agaatcagaa     1920

cccctgttaa tgtggagtgt ggtagatgct cggtgctgtg gtgctctgaa gacaggcgag     1980

gggaggcaga agcccaccac aggcccgctg ttagttctta gaggaaactc ctctctctct     2040

tatctaccag attagcaagg gcgctgtgat acagtttttt gagtacaaag acatttttta     2100

aaaagccttc cagttttgtg cattaaaacc tttttgtaaa tatggtttat aatactgttt     2160

tcaaacgcaa ggcaataatt atgttgcatc tgtgaacttt ggcaggtttg tgtaaaagga     2220

gggaagcctc tcttaaaaca gcaataacag aaaaggagga agcgggatgt ttttaccttg     2280

tcttgtaatc agggagctct caccacgtca gagaggaggc agcattggtc tcaccttact     2340

gttttttaca ttaccatgat tggttcatgg agcagggagg agtccacgag acttcacacg     2400

cttgtgcttt aactttctta actgggcaca agcaaagggc gccttcgtgt tcctctcttc     2460

atcttagtta atgcgcgagg aaaatgcttt gatggccatt tctcattcgc actgaaagcc     2520

gagaggtgac attttacggt ttcttgtttt taagcacgac atacttaatc attatttgag     2580

actgattatt ttagctaaat ttggggatat gccatggggc aagaaaacat gtactgagag     2640

atttctaaac acatctattt aagcatactt taaaaatatc tagcccaaag gtaagttgct     2700

gtatcctcac agttgtctgc atccagggaa tatgactgaa tataacatat ctttgtaatt     2760

gaattagttt ttgccacttc taactgaaaa cagaacagaa ggagtgccat aaatgcaaag     2820

aagcaaagtg tactgttgtc aacatactgt aatcagagga ggggtttcaa tgtgtctgga     2880

tgagagtgtg tgtgtttaag gtcagagtat agggtgttct tcaacttgga cagtagaaaa     2940

taggcatcaa gtgtgaaccg gtgaggcgtg gacagccttc ttgtgactga gatgcttgta     3000

agttctgtgc caggttctcc accactgtgt actttattgc tatttaaaac tgtatcaact     3060

ctaacgaaag aataaattat ttgtgatttt aaaaaaaaaa aaaaaaaaaa                3110


<210> 40
<211> 387
<212> PRT
<213> Mus musculus

<400> 40
Met Ser Val Ala Phe Ala Ala Pro Arg Gln Arg Gly Lys Gly Glu Ile 
1               5                   10                  15      


Thr Pro Ala Ala Ile Gln Lys Met Leu Asp Glu Asn Asn His Leu Ile 
            20                  25                  30          


Gln Cys Ile Met Asp Tyr Gln Asn Lys Gly Lys Ala Ser Glu Cys Ser 
        35                  40                  45              


Gln Tyr Gln Gln Ile Leu His Thr Asn Leu Val Tyr Leu Ala Thr Ile 
    50                  55                  60                  


Ala Asp Ser Asn Gln Asn Met Gln Ser Leu Leu Pro Ala Pro Pro Thr 
65                  70                  75                  80  


Gln Thr Met Pro Met Gly Pro Gly Gly Met Ser Gln Ser Gly Pro Pro 
                85                  90                  95      


Pro Pro Pro Arg Ser His Asn Met Pro Ser Asp Gly Met Val Gly Gly 
            100                 105                 110         


Gly Pro Pro Ala Pro His Met Gln Asn Gln Met Asn Gly Gln Met Pro 
        115                 120                 125             


Gly Pro Asn His Met Pro Met Gln Gly Pro Gly Pro Ser Gln Leu Ser 
    130                 135                 140                 


Met Thr Asn Ser Ser Met Asn Met Pro Ser Ser Ser His Gly Ser Met 
145                 150                 155                 160 


Gly Gly Tyr Asn His Ser Val Pro Ser Ser Gln Ser Met Pro Val Gln 
                165                 170                 175     


Asn Gln Met Thr Met Ser Gln Gly Gln Pro Met Gly Asn Tyr Gly Pro 
            180                 185                 190         


Arg Pro Asn Met Asn Met Gln Pro Asn Gln Gly Pro Met Met His Gln 
        195                 200                 205             


Gln Pro Pro Ser Gln Gln Tyr Asn Met Pro Pro Gly Gly Ala Gln His 
    210                 215                 220                 


Tyr Gln Gly Gln Gln Ala Pro Met Gly Leu Met Gly Gln Val Asn Gln 
225                 230                 235                 240 


Gly Ser His Met Met Gly Gln Arg Gln Met Pro Pro Tyr Arg Pro Pro 
                245                 250                 255     


Gln Gln Gly Pro Pro Gln Gln Tyr Ser Gly Gln Glu Asp Tyr Tyr Gly 
            260                 265                 270         


Asp Gln Tyr Ser His Gly Gly Gln Gly Pro Pro Glu Gly Met Asn Gln 
        275                 280                 285             


Gln Tyr Tyr Pro Asp Gly Asn Ser Gln Tyr Gly Gln Gln Gln Asp Ala 
    290                 295                 300                 


Tyr Gln Gly Pro Pro Pro Gln Gln Gly Tyr Pro Pro Gln Gln Gln Gln 
305                 310                 315                 320 


Tyr Pro Gly Gln Gln Gly Tyr Pro Gly Gln Gln Gln Ser Tyr Gly Pro 
                325                 330                 335     


Ser Gln Gly Gly Pro Gly Pro Gln Tyr Pro Asn Tyr Pro Gln Gly Gln 
            340                 345                 350         


Gly Gln Gln Tyr Gly Gly Tyr Arg Pro Thr Gln Pro Gly Pro Pro Gln 
        355                 360                 365             


Pro Pro Gln Gln Arg Pro Tyr Gly Tyr Asp Gln Gly Gln Tyr Gly Asn 
    370                 375                 380                 


Tyr Gln Gln 
385         


<210> 41
<211> 3017
<212> DNA
<213> Mus musculus

<400> 41
ccttgctggg agctgcggct cagcgttaag gccaagccgg ccagcgaggg acgcggcccg       60

ggagcatcct ccccccaccg cgcgccctaa ggtggaactg cccggaggcg ggcgtcgggc      120

ccccagctcc gcgggccctg gagcgctcgg gactcgctga tcgcgggctc ggcggcaaca      180

tgtctgtggc gttcgcagcc ccgaggcagc ggggcaaggg cgaaatcacg cccgccgcca      240

tccagaagat gctggatgaa aacaaccatc ttattcagtg tataatggac tatcagaaca      300

aagggaaggc ctcggagtgc tcgcagtatc agcagatatt gcatacaaac ctggtatacc      360

ttgctacaat agcagactct aatcaaaata tgcagtctct cttaccagca ccgcccacac      420

agactatgcc aatgggtcct ggagggatga gtcagagtgg ccctccaccc cctccccgct      480

ctcacaacat gccttcagat ggaatggtgg gtgggggccc tcctgcacca cacatgcaga      540

accagatgaa cggccagatg cctgggccta accatatgcc aatgcaggga cctggaccca      600

gtcagctcag catgacaaac agctccatga atatgccttc aagtagccat ggctccatgg      660

gaggttacaa ccattctgtg ccgtcatccc agagcatgcc cgtgcagaac cagatgacaa      720

tgagtcaggg gcagccaatg ggaaactatg gtcccagacc aaacatgaat atgcaaccaa      780

atcaagggcc gatgatgcac cagcagcctc cttctcagca gtacaatatg ccacctggag      840

gggcacagca ttaccaagga cagcaggcgc ccatggggct gatgggccaa gttaaccaag      900

gcagtcacat gatgggccag cgacagatgc ctccctacag acctccgcaa cagggcccac      960

cacagcagta ctcaggccag gaagactatt atggggacca atacagtcat ggtggacaag     1020

gtcctccaga aggcatgaac cagcaatatt accctgatgg aaactcccag tatggccaac     1080

agcaagacgc ttaccaggga ccacctccac agcaaggata cccaccccag cagcagcagt     1140

acccgggaca gcagggatac ccagggcagc agcagagcta tggtccttcg cagggcggtc     1200

caggtcctca gtatcctaat tatcctcagg gtcaaggtca gcagtatggg ggctatagac     1260

caacacagcc aggaccaccc cagccacccc agcagaggcc ttatgggtac gaccagggac     1320

agtatggaaa ttaccagcag tgaaaatgtc cttacattcc aatagccagt acctattagc     1380

aggcacgttg tcacagcact gcaccatgga cacccccctg ggaagactcc ttccattcca     1440

gctaggtttt tgggaaaacc tttggctaag tggctgcttc gtcagcaagt agctgttatg     1500

gtttagtttg taaaggcttc gtagctaccg atgcacctga tttcacgttt ctactctaga     1560

tggcaacatt ggacagaaaa tgcattgacg tgaggagttt gcagcggttt cagaactgtg     1620

ctgcaaatgg actgtcacag cctgaaaggt gtgagcagct gggtgtgtgt tcgcggagct     1680

tcagggggtt tcatactttt ccaccgatta ttttgtaagg ggaaggggga aatgtacact     1740

ttttacagca gcaatatttt gtctattatg tttatttcat gtgataaata tgcaaagcgg     1800

tacactacac actgggcaga atcagaaccc ctgttaatgt ggagtgtggt agatgctcgg     1860

tgctgtggtg ctctgaagac aggcgagggg aggcagaagc ccaccacagg cccgctgtta     1920

gttcttagag gaaactcctc tctctcttat ctaccagatt agcaagggcg ctgtgataca     1980

gttttttgag tacaaagaca ttttttaaaa agccttccag ttttgtgcat taaaaccttt     2040

ttgtaaatat ggtttataat actgttttca aacgcaaggc aataattatg ttgcatctgt     2100

gaactttggc aggtttgtgt aaaaggaggg aagcctctct taaaacagca ataacagaaa     2160

aggaggaagc gggatgtttt taccttgtct tgtaatcagg gagctctcac cacgtcagag     2220

aggaggcagc attggtctca ccttactgtt ttttacatta ccatgattgg ttcatggagc     2280

agggaggagt ccacgagact tcacacgctt gtgctttaac tttcttaact gggcacaagc     2340

aaagggcgcc ttcgtgttcc tctcttcatc ttagttaatg cgcgaggaaa atgctttgat     2400

ggccatttct cattcgcact gaaagccgag aggtgacatt ttacggtttc ttgtttttaa     2460

gcacgacata cttaatcatt atttgagact gattatttta gctaaatttg gggatatgcc     2520

atggggcaag aaaacatgta ctgagagatt tctaaacaca tctatttaag catactttaa     2580

aaatatctag cccaaaggta agttgctgta tcctcacagt tgtctgcatc cagggaatat     2640

gactgaatat aacatatctt tgtaattgaa ttagtttttg ccacttctaa ctgaaaacag     2700

aacagaagga gtgccataaa tgcaaagaag caaagtgtac tgttgtcaac atactgtaat     2760

cagaggaggg gtttcaatgt gtctggatga gagtgtgtgt gtttaaggtc agagtatagg     2820

gtgttcttca acttggacag tagaaaatag gcatcaagtg tgaaccggtg aggcgtggac     2880

agccttcttg tgactgagat gcttgtaagt tctgtgccag gttctccacc actgtgtact     2940

ttattgctat ttaaaactgt atcaactcta acgaaagaat aaattatttg tgattttaaa     3000

aaaaaaaaaa aaaaaaa                                                    3017


<210> 42
<211> 344
<212> PRT
<213> Mus musculus

<400> 42
Met Ser Val Ala Phe Ala Ala Pro Arg Gln Arg Gly Lys Gly Glu Ile 
1               5                   10                  15      


Thr Pro Ala Ala Ile Gln Lys Met Leu Asp Glu Asn Asn His Leu Ile 
            20                  25                  30          


Gln Cys Ile Met Asp Tyr Gln Asn Lys Gly Lys Ala Ser Glu Cys Ser 
        35                  40                  45              


Gln Tyr Gln Gln Ile Leu His Thr Asn Leu Val Tyr Leu Ala Thr Ile 
    50                  55                  60                  


Ala Asp Ser Asn Gln Asn Met Gln Ser Leu Leu Pro Ala Pro Pro Thr 
65                  70                  75                  80  


Gln Thr Met Pro Met Gly Pro Gly Gly Met Ser Gln Ser Gly Pro Pro 
                85                  90                  95      


Pro Pro Pro Arg Ser His Asn Met Pro Ser Asp Gly Met Val Gly Gly 
            100                 105                 110         


Gly Pro Pro Ala Pro His Met Gln Asn Gln Met Asn Gly Gln Met Pro 
        115                 120                 125             


Gly Pro Met Met His Gln Gln Pro Pro Ser Gln Gln Tyr Asn Met Pro 
    130                 135                 140                 


Pro Gly Gly Ala Gln His Tyr Gln Gly Gln Gln Ala Pro Met Gly Leu 
145                 150                 155                 160 


Met Gly Gln Val Asn Gln Gly Ser His Met Met Gly Gln Arg Gln Met 
                165                 170                 175     


Pro Pro Tyr Arg Pro Pro Gln Gln Gly Pro Pro Gln Gln Tyr Ser Gly 
            180                 185                 190         


Gln Glu Asp Tyr Tyr Gly Asp Gln Tyr Ser His Gly Gly Gln Gly Pro 
        195                 200                 205             


Pro Glu Gly Met Asn Gln Gln Tyr Tyr Pro Asp Gly His Asn Asp Tyr 
    210                 215                 220                 


Gly Tyr Gln Gln Pro Ser Tyr Pro Glu Gln Gly Tyr Asp Arg Pro Tyr 
225                 230                 235                 240 


Glu Asp Ser Ser Gln His Tyr Tyr Glu Gly Gly Asn Ser Gln Tyr Gly 
                245                 250                 255     


Gln Gln Gln Asp Ala Tyr Gln Gly Pro Pro Pro Gln Gln Gly Tyr Pro 
            260                 265                 270         


Pro Gln Gln Gln Gln Tyr Pro Gly Gln Gln Gly Tyr Pro Gly Gln Gln 
        275                 280                 285             


Gln Ser Tyr Gly Pro Ser Gln Gly Gly Pro Gly Pro Gln Tyr Pro Asn 
    290                 295                 300                 


Tyr Pro Gln Gly Gln Gly Gln Gln Tyr Gly Gly Tyr Arg Pro Thr Gln 
305                 310                 315                 320 


Pro Gly Pro Pro Gln Pro Pro Gln Gln Arg Pro Tyr Gly Tyr Asp Gln 
                325                 330                 335     


Gly Gln Tyr Gly Asn Tyr Gln Gln 
            340                 


<210> 43
<211> 2888
<212> DNA
<213> Mus musculus

<400> 43
ccttgctggg agctgcggct cagcgttaag gccaagccgg ccagcgaggg acgcggcccg       60

ggagcatcct ccccccaccg cgcgccctaa ggtggaactg cccggaggcg ggcgtcgggc      120

ccccagctcc gcgggccctg gagcgctcgg gactcgctga tcgcgggctc ggcggcaaca      180

tgtctgtggc gttcgcagcc ccgaggcagc ggggcaaggg cgaaatcacg cccgccgcca      240

tccagaagat gctggatgaa aacaaccatc ttattcagtg tataatggac tatcagaaca      300

aagggaaggc ctcggagtgc tcgcagtatc agcagatatt gcatacaaac ctggtatacc      360

ttgctacaat agcagactct aatcaaaata tgcagtctct cttaccagca ccgcccacac      420

agactatgcc aatgggtcct ggagggatga gtcagagtgg ccctccaccc cctccccgct      480

ctcacaacat gccttcagat ggaatggtgg gtgggggccc tcctgcacca cacatgcaga      540

accagatgaa cggccagatg cctgggccga tgatgcacca gcagcctcct tctcagcagt      600

acaatatgcc acctggaggg gcacagcatt accaaggaca gcaggcgccc atggggctga      660

tgggccaagt taaccaaggc agtcacatga tgggccagcg acagatgcct ccctacagac      720

ctccgcaaca gggcccacca cagcagtact caggccagga agactattat ggggaccaat      780

acagtcatgg tggacaaggt cctccagaag gcatgaacca gcaatattac cctgatggtc      840

ataatgatta cggttatcag caaccgtcgt atcctgaaca aggctacgat aggccttatg      900

aggattcctc acaacattac tacgaaggag gaaactccca gtatggccaa cagcaagacg      960

cttaccaggg accacctcca cagcaaggat acccacccca gcagcagcag tacccgggac     1020

agcagggata cccagggcag cagcagagct atggtccttc gcagggcggt ccaggtcctc     1080

agtatcctaa ttatcctcag ggtcaaggtc agcagtatgg gggctataga ccaacacagc     1140

caggaccacc ccagccaccc cagcagaggc cttatgggta cgaccaggga cagtatggaa     1200

attaccagca gtgaaaatgt ccttacattc caatagccag tacctattag caggcacgtt     1260

gtcacagcac tgcaccatgg acacccccct gggaagactc cttccattcc agctaggttt     1320

ttgggaaaac ctttggctaa gtggctgctt cgtcagcaag tagctgttat ggtttagttt     1380

gtaaaggctt cgtagctacc gatgcacctg atttcacgtt tctactctag atggcaacat     1440

tggacagaaa atgcattgac gtgaggagtt tgcagcggtt tcagaactgt gctgcaaatg     1500

gactgtcaca gcctgaaagg tgtgagcagc tgggtgtgtg ttcgcggagc ttcagggggt     1560

ttcatacttt tccaccgatt attttgtaag gggaaggggg aaatgtacac tttttacagc     1620

agcaatattt tgtctattat gtttatttca tgtgataaat atgcaaagcg gtacactaca     1680

cactgggcag aatcagaacc cctgttaatg tggagtgtgg tagatgctcg gtgctgtggt     1740

gctctgaaga caggcgaggg gaggcagaag cccaccacag gcccgctgtt agttcttaga     1800

ggaaactcct ctctctctta tctaccagat tagcaagggc gctgtgatac agttttttga     1860

gtacaaagac attttttaaa aagccttcca gttttgtgca ttaaaacctt tttgtaaata     1920

tggtttataa tactgttttc aaacgcaagg caataattat gttgcatctg tgaactttgg     1980

caggtttgtg taaaaggagg gaagcctctc ttaaaacagc aataacagaa aaggaggaag     2040

cgggatgttt ttaccttgtc ttgtaatcag ggagctctca ccacgtcaga gaggaggcag     2100

cattggtctc accttactgt tttttacatt accatgattg gttcatggag cagggaggag     2160

tccacgagac ttcacacgct tgtgctttaa ctttcttaac tgggcacaag caaagggcgc     2220

cttcgtgttc ctctcttcat cttagttaat gcgcgaggaa aatgctttga tggccatttc     2280

tcattcgcac tgaaagccga gaggtgacat tttacggttt cttgttttta agcacgacat     2340

acttaatcat tatttgagac tgattatttt agctaaattt ggggatatgc catggggcaa     2400

gaaaacatgt actgagagat ttctaaacac atctatttaa gcatacttta aaaatatcta     2460

gcccaaaggt aagttgctgt atcctcacag ttgtctgcat ccagggaata tgactgaata     2520

taacatatct ttgtaattga attagttttt gccacttcta actgaaaaca gaacagaagg     2580

agtgccataa atgcaaagaa gcaaagtgta ctgttgtcaa catactgtaa tcagaggagg     2640

ggtttcaatg tgtctggatg agagtgtgtg tgtttaaggt cagagtatag ggtgttcttc     2700

aacttggaca gtagaaaata ggcatcaagt gtgaaccggt gaggcgtgga cagccttctt     2760

gtgactgaga tgcttgtaag ttctgtgcca ggttctccac cactgtgtac tttattgcta     2820

tttaaaactg tatcaactct aacgaaagaa taaattattt gtgattttaa aaaaaaaaaa     2880

aaaaaaaa                                                              2888


<210> 44
<211> 313
<212> PRT
<213> Mus musculus

<400> 44
Met Ser Val Ala Phe Ala Ala Pro Arg Gln Arg Gly Lys Gly Glu Ile 
1               5                   10                  15      


Thr Pro Ala Ala Ile Gln Lys Met Leu Asp Glu Asn Asn His Leu Ile 
            20                  25                  30          


Gln Cys Ile Met Asp Tyr Gln Asn Lys Gly Lys Ala Ser Glu Cys Ser 
        35                  40                  45              


Gln Tyr Gln Gln Ile Leu His Thr Asn Leu Val Tyr Leu Ala Thr Ile 
    50                  55                  60                  


Ala Asp Ser Asn Gln Asn Met Gln Ser Leu Leu Pro Ala Pro Pro Thr 
65                  70                  75                  80  


Gln Thr Met Pro Met Gly Pro Gly Gly Met Ser Gln Ser Gly Pro Pro 
                85                  90                  95      


Pro Pro Pro Arg Ser His Asn Met Pro Ser Asp Gly Met Val Gly Gly 
            100                 105                 110         


Gly Pro Pro Ala Pro His Met Gln Asn Gln Met Asn Gly Gln Met Pro 
        115                 120                 125             


Gly Pro Met Met His Gln Gln Pro Pro Ser Gln Gln Tyr Asn Met Pro 
    130                 135                 140                 


Pro Gly Gly Ala Gln His Tyr Gln Gly Gln Gln Ala Pro Met Gly Leu 
145                 150                 155                 160 


Met Gly Gln Val Asn Gln Gly Ser His Met Met Gly Gln Arg Gln Met 
                165                 170                 175     


Pro Pro Tyr Arg Pro Pro Gln Gln Gly Pro Pro Gln Gln Tyr Ser Gly 
            180                 185                 190         


Gln Glu Asp Tyr Tyr Gly Asp Gln Tyr Ser His Gly Gly Gln Gly Pro 
        195                 200                 205             


Pro Glu Gly Met Asn Gln Gln Tyr Tyr Pro Asp Gly Asn Ser Gln Tyr 
    210                 215                 220                 


Gly Gln Gln Gln Asp Ala Tyr Gln Gly Pro Pro Pro Gln Gln Gly Tyr 
225                 230                 235                 240 


Pro Pro Gln Gln Gln Gln Tyr Pro Gly Gln Gln Gly Tyr Pro Gly Gln 
                245                 250                 255     


Gln Gln Ser Tyr Gly Pro Ser Gln Gly Gly Pro Gly Pro Gln Tyr Pro 
            260                 265                 270         


Asn Tyr Pro Gln Gly Gln Gly Gln Gln Tyr Gly Gly Tyr Arg Pro Thr 
        275                 280                 285             


Gln Pro Gly Pro Pro Gln Pro Pro Gln Gln Arg Pro Tyr Gly Tyr Asp 
    290                 295                 300                 


Gln Gly Gln Tyr Gly Asn Tyr Gln Gln 
305                 310             


<210> 45
<211> 2795
<212> DNA
<213> Mus musculus

<400> 45
ccttgctggg agctgcggct cagcgttaag gccaagccgg ccagcgaggg acgcggcccg       60

ggagcatcct ccccccaccg cgcgccctaa ggtggaactg cccggaggcg ggcgtcgggc      120

ccccagctcc gcgggccctg gagcgctcgg gactcgctga tcgcgggctc ggcggcaaca      180

tgtctgtggc gttcgcagcc ccgaggcagc ggggcaaggg cgaaatcacg cccgccgcca      240

tccagaagat gctggatgaa aacaaccatc ttattcagtg tataatggac tatcagaaca      300

aagggaaggc ctcggagtgc tcgcagtatc agcagatatt gcatacaaac ctggtatacc      360

ttgctacaat agcagactct aatcaaaata tgcagtctct cttaccagca ccgcccacac      420

agactatgcc aatgggtcct ggagggatga gtcagagtgg ccctccaccc cctccccgct      480

ctcacaacat gccttcagat ggaatggtgg gtgggggccc tcctgcacca cacatgcaga      540

accagatgaa cggccagatg cctgggccga tgatgcacca gcagcctcct tctcagcagt      600

acaatatgcc acctggaggg gcacagcatt accaaggaca gcaggcgccc atggggctga      660

tgggccaagt taaccaaggc agtcacatga tgggccagcg acagatgcct ccctacagac      720

ctccgcaaca gggcccacca cagcagtact caggccagga agactattat ggggaccaat      780

acagtcatgg tggacaaggt cctccagaag gcatgaacca gcaatattac cctgatggaa      840

actcccagta tggccaacag caagacgctt accagggacc acctccacag caaggatacc      900

caccccagca gcagcagtac ccgggacagc agggataccc agggcagcag cagagctatg      960

gtccttcgca gggcggtcca ggtcctcagt atcctaatta tcctcagggt caaggtcagc     1020

agtatggggg ctatagacca acacagccag gaccacccca gccaccccag cagaggcctt     1080

atgggtacga ccagggacag tatggaaatt accagcagtg aaaatgtcct tacattccaa     1140

tagccagtac ctattagcag gcacgttgtc acagcactgc accatggaca cccccctggg     1200

aagactcctt ccattccagc taggtttttg ggaaaacctt tggctaagtg gctgcttcgt     1260

cagcaagtag ctgttatggt ttagtttgta aaggcttcgt agctaccgat gcacctgatt     1320

tcacgtttct actctagatg gcaacattgg acagaaaatg cattgacgtg aggagtttgc     1380

agcggtttca gaactgtgct gcaaatggac tgtcacagcc tgaaaggtgt gagcagctgg     1440

gtgtgtgttc gcggagcttc agggggtttc atacttttcc accgattatt ttgtaagggg     1500

aagggggaaa tgtacacttt ttacagcagc aatattttgt ctattatgtt tatttcatgt     1560

gataaatatg caaagcggta cactacacac tgggcagaat cagaacccct gttaatgtgg     1620

agtgtggtag atgctcggtg ctgtggtgct ctgaagacag gcgaggggag gcagaagccc     1680

accacaggcc cgctgttagt tcttagagga aactcctctc tctcttatct accagattag     1740

caagggcgct gtgatacagt tttttgagta caaagacatt ttttaaaaag ccttccagtt     1800

ttgtgcatta aaaccttttt gtaaatatgg tttataatac tgttttcaaa cgcaaggcaa     1860

taattatgtt gcatctgtga actttggcag gtttgtgtaa aaggagggaa gcctctctta     1920

aaacagcaat aacagaaaag gaggaagcgg gatgttttta ccttgtcttg taatcaggga     1980

gctctcacca cgtcagagag gaggcagcat tggtctcacc ttactgtttt ttacattacc     2040

atgattggtt catggagcag ggaggagtcc acgagacttc acacgcttgt gctttaactt     2100

tcttaactgg gcacaagcaa agggcgcctt cgtgttcctc tcttcatctt agttaatgcg     2160

cgaggaaaat gctttgatgg ccatttctca ttcgcactga aagccgagag gtgacatttt     2220

acggtttctt gtttttaagc acgacatact taatcattat ttgagactga ttattttagc     2280

taaatttggg gatatgccat ggggcaagaa aacatgtact gagagatttc taaacacatc     2340

tatttaagca tactttaaaa atatctagcc caaaggtaag ttgctgtatc ctcacagttg     2400

tctgcatcca gggaatatga ctgaatataa catatctttg taattgaatt agtttttgcc     2460

acttctaact gaaaacagaa cagaaggagt gccataaatg caaagaagca aagtgtactg     2520

ttgtcaacat actgtaatca gaggaggggt ttcaatgtgt ctggatgaga gtgtgtgtgt     2580

ttaaggtcag agtatagggt gttcttcaac ttggacagta gaaaataggc atcaagtgtg     2640

aaccggtgag gcgtggacag ccttcttgtg actgagatgc ttgtaagttc tgtgccaggt     2700

tctccaccac tgtgtacttt attgctattt aaaactgtat caactctaac gaaagaataa     2760

attatttgtg attttaaaaa aaaaaaaaaa aaaaa                                2795


<210> 46
<211> 8585
<212> DNA
<213> Homo sapiens

<400> 46
cagaaagcgg agagtcacag cggggccagg ccctggggag cggagcctcc accgcccccc       60

tcattcccag gcaagggctt ggggggaatg agccgggaga gccgggtccc gagcctacag      120

agccgggagc agctgagccg ccggcgcctc ggccgccgcc gccgcctcct cctcctccgc      180

cgccgccagc ccggagcctg agccggcggg gcggggggga gaggagcgag cgcagcgcag      240

cagcggagcc ccgcgaggcc cgcccgggcg ggtggggagg gcagcccggg ggactgggcc      300

ccggggcggg gtgggagggg gggagaagac gaagacaggg ccgggtctct ccgcggacga      360

gacagcgggg atcatggccg cgcaggtcgc ccccgccgcc gccagcagcc tgggcaaccc      420

gccgccgccg ccgccctcgg agctgaagaa agccgagcag cagcagcggg aggaggcggg      480

gggcgaggcg gcggcggcgg cagcggccga gcgcggggaa atgaaggcag ccgccgggca      540

ggaaagcgag ggccccgccg tggggccgcc gcagccgctg ggaaaggagc tgcaggacgg      600

ggccgagagc aatgggggtg gcggcggcgg cggagccggc agcggcggcg ggcccggcgc      660

ggagccggac ctgaagaact cgaacgggaa cgcgggccct aggcccgccc tgaacaataa      720

cctcacggag ccgcccggcg gcggcggtgg cggcagcagc gatggggtgg gggcgcctcc      780

tcactcagcc gcggccgcct tgccgccccc agcctacggc ttcgggcaac cctacggccg      840

gagcccgtct gccgtcgccg ccgccgcggc cgccgtcttc caccaacaac atggcggaca      900

acaaagccct ggcctggcag cgctgcagag cggcggcggc gggggcctgg agccctacgc      960

ggggccccag cagaactctc acgaccacgg cttccccaac caccagtaca actcctacta     1020

ccccaaccgc agcgcctacc ccccgcccgc cccggcctac gcgctgagct ccccgagagg     1080

tggcactccg ggctccggcg cggcggcggc tgccggctcc aagccgcctc cctcctccag     1140

cgcctccgcc tcctcgtcgt cttcgtcctt cgctcagcag cgcttcgggg ccatgggggg     1200

aggcggcccc tccgcggccg gcgggggaac tccccagccc accgccaccc ccaccctcaa     1260

ccaactgctc acgtcgccca gctcggcccg gggctaccag ggctaccccg ggggcgacta     1320

cagtggcggg ccccaggacg ggggcgccgg caagggcccg gcggacatgg cctcgcagtg     1380

ttggggggct gcggcggcgg cagctgcggc ggcggccgcc tcgggagggg cccaacaaag     1440

gagccaccac gcgcccatga gccccgggag cagcggcggc ggggggcagc cgctcgcccg     1500

gacccctcag ccatccagtc caatggatca gatgggcaag atgagacctc agccatatgg     1560

cgggactaac ccatactcgc agcaacaggg acctccgtca ggaccgcagc aaggacatgg     1620

gtacccaggg cagccatacg ggtcccagac cccgcagcgg tacccgatga ccatgcaggg     1680

ccgggcgcag agtgccatgg gcggcctctc ttatacacag cagattcctc cttatggaca     1740

acaaggcccc agcgggtatg gtcaacaggg ccagactcca tattacaacc agcaaagtcc     1800

tcaccctcag cagcagcagc caccctactc ccagcaacca ccgtcccaga cccctcatgc     1860

ccaaccttcg tatcagcagc agccacagtc tcaaccacca cagctccagt cctctcagcc     1920

tccatactcc cagcagccat cccagcctcc acatcagcag tccccggctc catacccctc     1980

ccagcagtcg acgacacagc agcaccccca gagccagccc ccctactcac agccacaggc     2040

tcagtctcct taccagcagc agcaacctca gcagccagca ccctcgacgc tctcccagca     2100

ggctgcgtat cctcagcccc agtctcagca gtcccagcaa actgcctatt cccagcagcg     2160

cttccctcca ccgcaggagc tatctcaaga ttcatttggg tctcaggcat cctcagcccc     2220

ctcaatgacc tccagtaagg gagggcaaga agatatgaac ctgagccttc agtcaagacc     2280

ctccagcttg cctgatctat ctggttcaat agatgacctc cccatgggga cagaaggagc     2340

tctgagtcct ggagtgagca catcagggat ttccagcagc caaggagagc agagtaatcc     2400

agctcagtct cctttctctc ctcatacctc ccctcacctg cctggcatcc gaggcccttc     2460

cccgtcccct gttggctctc ccgccagtgt tgctcagtct cgctcaggac cactctcgcc     2520

tgctgcagtg ccaggcaacc agatgccacc tcggccaccc agtggccagt cggacagcat     2580

catgcatcct tccatgaacc aatcaagcat tgcccaagat cgaggttata tgcagaggaa     2640

cccccagatg ccccagtaca gttcccccca gcccggctca gccttatctc cgcgtcagcc     2700

ttccggagga cagatacaca caggcatggg ctcctaccag cagaactcca tggggagcta     2760

tggtccccag gggggtcagt atggcccaca aggtggctac cccaggcagc caaactataa     2820

tgccttgccc aatgccaact accccagtgc aggcatggct ggaggcataa accccatggg     2880

tgccggaggt caaatgcatg gacagcctgg catcccacct tatggcacac tccctccagg     2940

gaggatgagt cacgcctcca tgggcaaccg gccttatggc cctaacatgg ccaatatgcc     3000

acctcaggtt gggtcaggga tgtgtccccc accagggggc atgaaccgga aaacccaaga     3060

aactgctgtc gccatgcatg ttgctgccaa ctctatccaa aacaggccgc caggctaccc     3120

caatatgaat caagggggca tgatgggaac tggacctcct tatggacaag ggattaatag     3180

tatggctggc atgatcaacc ctcagggacc cccatattcc atgggtggaa ccatggccaa     3240

caattctgca gggatggcag ccagcccaga gatgatgggc cttggggatg taaagttaac     3300

tccagccacc aaaatgaaca acaaggcaga tgggacaccc aagacagaat ccaaatccaa     3360

gaaatccagt tcttctacta caaccaatga gaagatcacc aagttgtatg agctgggtgg     3420

tgagcctgag aggaagatgt gggtggaccg ttatctggcc ttcactgagg agaaggccat     3480

gggcatgaca aatctgcctg ctgtgggtag gaaacctctg gacctctatc gcctctatgt     3540

gtctgtgaag gagattggtg gattgactca ggtcaacaag aacaaaaaat ggcgggaact     3600

tgcaaccaac ctcaatgtgg gcacatcaag cagtgctgcc agctccttga aaaagcagta     3660

tatccagtgt ctctatgcct ttgaatgcaa gattgaacgg ggagaagacc ctcccccaga     3720

catctttgca gctgctgatt ccaagaagtc ccagcccaag atccagcctc cctctcctgc     3780

gggatcagga tctatgcagg ggccccagac tccccagtca accagcagtt ccatggcaga     3840

aggaggagac ttaaagccac caactccagc atccacacca cacagtcaga tccccccatt     3900

gccaggcatg agcaggagca attcagttgg gatccaggat gcctttaatg atggaagtga     3960

ctccacattc cagaagcgga attccatgac tccaaaccct gggtatcagc ccagtatgaa     4020

tacctctgac atgatggggc gcatgtccta tgagccaaat aaggatcctt atggcagcat     4080

gaggaaagct ccagggagtg atcccttcat gtcctcaggg cagggcccca acggcgggat     4140

gggtgacccc tacagtcgtg ctgccggccc tgggctagga aatgtggcga tgggaccacg     4200

acagcactat ccctatggag gtccttatga cagagtgagg acggagcctg gaatagggcc     4260

tgagggaaac atgagcactg gggccccaca gccgaatctc atgccttcca acccagactc     4320

ggggatgtat tctcctagcc gctacccccc gcagcagcag cagcagcagc agcaacgaca     4380

tgattcctat ggcaatcagt tctccaccca aggcacccct tctggcagcc ccttccccag     4440

ccagcagact acaatgtatc aacagcaaca gcagaattac aagcggccaa tggatggcac     4500

atatggccct cctgccaagc ggcacgaagg ggagatgtac agcgtgccat acagcactgg     4560

gcaggggcag cctcagcagc agcagttgcc cccagcccag ccccagcctg ccagccagca     4620

acaagctgcc cagccttccc ctcagcaaga tgtatacaac cagtatggca atgcctatcc     4680

tgccactgcc acagctgcta ctgagcgccg accagcaggc ggcccccaga accaatttcc     4740

attccagttt ggccgagacc gtgtctctgc accccctggc accaatgccc agcaaaacat     4800

gccaccacaa atgatgggcg gccccataca ggcatcagct gaggttgctc agcaaggcac     4860

catgtggcag gggcgtaatg acatgaccta taattatgcc aacaggcaga gcacgggctc     4920

tgccccccag ggccccgcct atcatggcgt gaaccgaaca gatgaaatgc tgcacacaga     4980

tcagagggcc aaccacgaag gctcgtggcc ttcccatggc acacgccagc ccccatatgg     5040

tccctctgcc cctgtgcccc ccatgacaag gccccctcca tctaactacc agcccccacc     5100

aagcatgcag aatcacattc ctcaggtatc cagccctgct cccctgcccc ggccaatgga     5160

gaaccgcacc tctcctagca agtctccatt cctgcactct gggatgaaaa tgcagaaggc     5220

aggtccccca gtacctgcct cgcacatagc acctgcccct gtgcagcccc ccatgattcg     5280

gcgggatatc accttcccac ctggctctgt tgaagccaca cagcctgtgt tgaagcagag     5340

gaggcggctc acaatgaaag acattggaac cccggaggca tggcgggtaa tgatgtccct     5400

caagtctggt ctcctggcag agagcacatg ggcattagat accatcaaca tcctgctgta     5460

tgatgacaac agcatcatga ccttcaacct cagtcagctc ccagggttgc tagagctcct     5520

tgtagaatat ttccgacgat gcctgattga gatctttggc attttaaagg agtatgaggt     5580

gggtgaccca ggacagagaa cgctactgga tcctgggagg ttcagcaagg tgtctagtcc     5640

agctcccatg gagggtgggg aagaagaaga agaacttcta ggtcctaaac tagaagagga     5700

agaagaagag gaagtagttg aaaatgatga ggagatagcc ttttcaggca aggacaagcc     5760

agcttcagag aatagtgagg agaagctgat cagtaagttt gacaagcttc cagtaaagat     5820

cgtacagaag aatgatccat ttgtggtgga ctgctcagat aagcttgggc gtgtgcagga     5880

gtttgacagt ggcctgctgc actggcggat tggtgggggg gacaccactg agcatatcca     5940

gacccacttc gagagcaaga cagagctgct gccttcccgg cctcacgcac cctgcccacc     6000

agcccctcgg aagcatgtga caacagcaga gggtacacca gggacaacag accaggaggg     6060

gcccccacct gatggacctc cagaaaaacg gatcacagcc actatggatg acatgttgtc     6120

tactcggtct agcaccttga ccgaggatgg agctaagagt tcagaggcca tcaaggagag     6180

cagcaagttt ccatttggca ttagcccagc acagagccac cggaacatca agatcctaga     6240

ggacgaaccc cacagtaagg atgagacccc actgtgtacc cttctggact ggcaggattc     6300

tcttgccaag cgctgcgtct gtgtgtccaa taccattcga agcctgtcat ttgtgccagg     6360

caatgacttt gagatgtcca aacacccagg gctgctgctc atcctgggca agctgatcct     6420

gctgcaccac aagcacccag aacggaagca ggcaccacta acttatgaaa aggaggagga     6480

acaggaccaa ggggtgagct gcaacaaagt ggagtggtgg tgggactgct tggagatgct     6540

ccgggaaaac accttggtta cactcgccaa catctcgggg cagttggacc tatctccata     6600

ccccgagagc atttgcctgc ctgtcctgga cggactccta cactgggcag tttgcccttc     6660

agctgaagcc caggacccct tttccaccct gggccccaat gccgtccttt ccccgcagag     6720

actggtcttg gaaaccctca gcaaactcag catccaggac aacaatgtgg acctgattct     6780

ggccacaccc cccttcagcc gcctggagaa gttgtatagc actatggtgc gcttcctcag     6840

tgaccgaaag aacccggtgt gccgggagat ggctgtggta ctgctggcca acctggctca     6900

gggggacagc ctggcagctc gtgccattgc agtgcagaag ggcagtatcg gcaacctcct     6960

gggcttccta gaggacagcc ttgccgccac acagttccag cagagccagg ccagcctcct     7020

ccacatgcag aacccaccct ttgagccaac tagtgtggac atgatgcggc gggctgcccg     7080

cgcgctgctt gccttggcca aggtggacga gaaccactca gagtttactc tgtacgaatc     7140

acggctgttg gacatctcgg tatcaccgtt gatgaactca ttggtttcac aagtcatttg     7200

tgatgtactg tttttgattg gccagtcatg acagccgtgg gacacctccc ccccccgtgt     7260

gtgtgtgcgt gtgtggagaa cttagaaact gactgttgcc ctttatttat gcaaaaccac     7320

ctcagaatcc agtttaccct gtgctgtcca gcttctccct tgggaaaaag tctctcctgt     7380

ttctctctcc tccttccacc tcccctccct ccatcacctc acgcctttct gttccttgtc     7440

ctcaccttac tcccctcagg accctacccc accctctttg aaaagacaaa gctctgccta     7500

catagaagac tttttttatt ttaaccaaag ttactgttgt ttacagtgag tttggggaaa     7560

aaaaataaaa taaaaatggc tttcccagtc cttgcatcaa cgggatgcca catttcataa     7620

ctgtttttaa tggtaaaaaa aaaaaaaaaa aatacaaaaa aaaattctga aggacaaaaa     7680

aggtgactgc tgaactgtgt gtggtttatt gttgtacatt cacaatcttg caggagccaa     7740

gaagttcgca gttgtgaaca gaccctgttc actggagagg cctgtgcagt agagtgtaga     7800

ccctttcatg tactgtactg tacacctgat actgtaaaca tactgtaata ataatgtctc     7860

acatggaaac agaaaacgct gggtcagcag caagctgtag tttttaaaaa tgtttttagt     7920

taaacgttga ggagaaaaaa aaaaaaggct tttcccccaa agtatcatgt gtgaacctac     7980

aacaccctga cctctttctc tcctccttga ttgtatgaat aaccctgaga tcacctctta     8040

gaactggttt taacctttag ctgcagcggc tacgctgcca cgtgtgtata tatatgacgt     8100

tgtacattgc acataccctt ggatccccac agtttggtcc tcctcccagc taccccttta     8160

tagtatgacg agttaacaag ttggtgacct gcacaaagcg agacacagct atttaatctc     8220

ttgccagata tcgcccctct tggtgcgatg ctgtacaggt ctctgtaaaa agtccttgct     8280

gtctcagcag ccaatcaact tatagtttat ttttttctgg gtttttgttt tgttttgttt     8340

tctttctaat cgaggtgtga aaaagttcta ggttcagttg aagttctgat gaagaaacac     8400

aattgagatt ttttcagtga taaaatctgc atatttgtat ttcaacaatg tagctaaaac     8460

ttgatgtaaa ttcctccttt ttttcctttt ttggcttaat gaatatcatt tattcagtat     8520

gaaatcttta tactatatgt tccacgtgtt aagaataaat gtacattaaa tcttggtaag     8580

acttt                                                                 8585


<210> 47
<211> 2285
<212> PRT
<213> Homo sapiens

<400> 47
Met Ala Ala Gln Val Ala Pro Ala Ala Ala Ser Ser Leu Gly Asn Pro 
1               5                   10                  15      


Pro Pro Pro Pro Pro Ser Glu Leu Lys Lys Ala Glu Gln Gln Gln Arg 
            20                  25                  30          


Glu Glu Ala Gly Gly Glu Ala Ala Ala Ala Ala Ala Ala Glu Arg Gly 
        35                  40                  45              


Glu Met Lys Ala Ala Ala Gly Gln Glu Ser Glu Gly Pro Ala Val Gly 
    50                  55                  60                  


Pro Pro Gln Pro Leu Gly Lys Glu Leu Gln Asp Gly Ala Glu Ser Asn 
65                  70                  75                  80  


Gly Gly Gly Gly Gly Gly Gly Ala Gly Ser Gly Gly Gly Pro Gly Ala 
                85                  90                  95      


Glu Pro Asp Leu Lys Asn Ser Asn Gly Asn Ala Gly Pro Arg Pro Ala 
            100                 105                 110         


Leu Asn Asn Asn Leu Thr Glu Pro Pro Gly Gly Gly Gly Gly Gly Ser 
        115                 120                 125             


Ser Asp Gly Val Gly Ala Pro Pro His Ser Ala Ala Ala Ala Leu Pro 
    130                 135                 140                 


Pro Pro Ala Tyr Gly Phe Gly Gln Pro Tyr Gly Arg Ser Pro Ser Ala 
145                 150                 155                 160 


Val Ala Ala Ala Ala Ala Ala Val Phe His Gln Gln His Gly Gly Gln 
                165                 170                 175     


Gln Ser Pro Gly Leu Ala Ala Leu Gln Ser Gly Gly Gly Gly Gly Leu 
            180                 185                 190         


Glu Pro Tyr Ala Gly Pro Gln Gln Asn Ser His Asp His Gly Phe Pro 
        195                 200                 205             


Asn His Gln Tyr Asn Ser Tyr Tyr Pro Asn Arg Ser Ala Tyr Pro Pro 
    210                 215                 220                 


Pro Ala Pro Ala Tyr Ala Leu Ser Ser Pro Arg Gly Gly Thr Pro Gly 
225                 230                 235                 240 


Ser Gly Ala Ala Ala Ala Ala Gly Ser Lys Pro Pro Pro Ser Ser Ser 
                245                 250                 255     


Ala Ser Ala Ser Ser Ser Ser Ser Ser Phe Ala Gln Gln Arg Phe Gly 
            260                 265                 270         


Ala Met Gly Gly Gly Gly Pro Ser Ala Ala Gly Gly Gly Thr Pro Gln 
        275                 280                 285             


Pro Thr Ala Thr Pro Thr Leu Asn Gln Leu Leu Thr Ser Pro Ser Ser 
    290                 295                 300                 


Ala Arg Gly Tyr Gln Gly Tyr Pro Gly Gly Asp Tyr Ser Gly Gly Pro 
305                 310                 315                 320 


Gln Asp Gly Gly Ala Gly Lys Gly Pro Ala Asp Met Ala Ser Gln Cys 
                325                 330                 335     


Trp Gly Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ser Gly Gly 
            340                 345                 350         


Ala Gln Gln Arg Ser His His Ala Pro Met Ser Pro Gly Ser Ser Gly 
        355                 360                 365             


Gly Gly Gly Gln Pro Leu Ala Arg Thr Pro Gln Pro Ser Ser Pro Met 
    370                 375                 380                 


Asp Gln Met Gly Lys Met Arg Pro Gln Pro Tyr Gly Gly Thr Asn Pro 
385                 390                 395                 400 


Tyr Ser Gln Gln Gln Gly Pro Pro Ser Gly Pro Gln Gln Gly His Gly 
                405                 410                 415     


Tyr Pro Gly Gln Pro Tyr Gly Ser Gln Thr Pro Gln Arg Tyr Pro Met 
            420                 425                 430         


Thr Met Gln Gly Arg Ala Gln Ser Ala Met Gly Gly Leu Ser Tyr Thr 
        435                 440                 445             


Gln Gln Ile Pro Pro Tyr Gly Gln Gln Gly Pro Ser Gly Tyr Gly Gln 
    450                 455                 460                 


Gln Gly Gln Thr Pro Tyr Tyr Asn Gln Gln Ser Pro His Pro Gln Gln 
465                 470                 475                 480 


Gln Gln Pro Pro Tyr Ser Gln Gln Pro Pro Ser Gln Thr Pro His Ala 
                485                 490                 495     


Gln Pro Ser Tyr Gln Gln Gln Pro Gln Ser Gln Pro Pro Gln Leu Gln 
            500                 505                 510         


Ser Ser Gln Pro Pro Tyr Ser Gln Gln Pro Ser Gln Pro Pro His Gln 
        515                 520                 525             


Gln Ser Pro Ala Pro Tyr Pro Ser Gln Gln Ser Thr Thr Gln Gln His 
    530                 535                 540                 


Pro Gln Ser Gln Pro Pro Tyr Ser Gln Pro Gln Ala Gln Ser Pro Tyr 
545                 550                 555                 560 


Gln Gln Gln Gln Pro Gln Gln Pro Ala Pro Ser Thr Leu Ser Gln Gln 
                565                 570                 575     


Ala Ala Tyr Pro Gln Pro Gln Ser Gln Gln Ser Gln Gln Thr Ala Tyr 
            580                 585                 590         


Ser Gln Gln Arg Phe Pro Pro Pro Gln Glu Leu Ser Gln Asp Ser Phe 
        595                 600                 605             


Gly Ser Gln Ala Ser Ser Ala Pro Ser Met Thr Ser Ser Lys Gly Gly 
    610                 615                 620                 


Gln Glu Asp Met Asn Leu Ser Leu Gln Ser Arg Pro Ser Ser Leu Pro 
625                 630                 635                 640 


Asp Leu Ser Gly Ser Ile Asp Asp Leu Pro Met Gly Thr Glu Gly Ala 
                645                 650                 655     


Leu Ser Pro Gly Val Ser Thr Ser Gly Ile Ser Ser Ser Gln Gly Glu 
            660                 665                 670         


Gln Ser Asn Pro Ala Gln Ser Pro Phe Ser Pro His Thr Ser Pro His 
        675                 680                 685             


Leu Pro Gly Ile Arg Gly Pro Ser Pro Ser Pro Val Gly Ser Pro Ala 
    690                 695                 700                 


Ser Val Ala Gln Ser Arg Ser Gly Pro Leu Ser Pro Ala Ala Val Pro 
705                 710                 715                 720 


Gly Asn Gln Met Pro Pro Arg Pro Pro Ser Gly Gln Ser Asp Ser Ile 
                725                 730                 735     


Met His Pro Ser Met Asn Gln Ser Ser Ile Ala Gln Asp Arg Gly Tyr 
            740                 745                 750         


Met Gln Arg Asn Pro Gln Met Pro Gln Tyr Ser Ser Pro Gln Pro Gly 
        755                 760                 765             


Ser Ala Leu Ser Pro Arg Gln Pro Ser Gly Gly Gln Ile His Thr Gly 
    770                 775                 780                 


Met Gly Ser Tyr Gln Gln Asn Ser Met Gly Ser Tyr Gly Pro Gln Gly 
785                 790                 795                 800 


Gly Gln Tyr Gly Pro Gln Gly Gly Tyr Pro Arg Gln Pro Asn Tyr Asn 
                805                 810                 815     


Ala Leu Pro Asn Ala Asn Tyr Pro Ser Ala Gly Met Ala Gly Gly Ile 
            820                 825                 830         


Asn Pro Met Gly Ala Gly Gly Gln Met His Gly Gln Pro Gly Ile Pro 
        835                 840                 845             


Pro Tyr Gly Thr Leu Pro Pro Gly Arg Met Ser His Ala Ser Met Gly 
    850                 855                 860                 


Asn Arg Pro Tyr Gly Pro Asn Met Ala Asn Met Pro Pro Gln Val Gly 
865                 870                 875                 880 


Ser Gly Met Cys Pro Pro Pro Gly Gly Met Asn Arg Lys Thr Gln Glu 
                885                 890                 895     


Thr Ala Val Ala Met His Val Ala Ala Asn Ser Ile Gln Asn Arg Pro 
            900                 905                 910         


Pro Gly Tyr Pro Asn Met Asn Gln Gly Gly Met Met Gly Thr Gly Pro 
        915                 920                 925             


Pro Tyr Gly Gln Gly Ile Asn Ser Met Ala Gly Met Ile Asn Pro Gln 
    930                 935                 940                 


Gly Pro Pro Tyr Ser Met Gly Gly Thr Met Ala Asn Asn Ser Ala Gly 
945                 950                 955                 960 


Met Ala Ala Ser Pro Glu Met Met Gly Leu Gly Asp Val Lys Leu Thr 
                965                 970                 975     


Pro Ala Thr Lys Met Asn Asn Lys Ala Asp Gly Thr Pro Lys Thr Glu 
            980                 985                 990         


Ser Lys Ser Lys Lys Ser Ser Ser  Ser Thr Thr Thr Asn  Glu Lys Ile 
        995                 1000                 1005             


Thr Lys  Leu Tyr Glu Leu Gly  Gly Glu Pro Glu Arg  Lys Met Trp 
    1010                 1015                 1020             


Val Asp  Arg Tyr Leu Ala Phe  Thr Glu Glu Lys Ala  Met Gly Met 
    1025                 1030                 1035             


Thr Asn  Leu Pro Ala Val Gly  Arg Lys Pro Leu Asp  Leu Tyr Arg 
    1040                 1045                 1050             


Leu Tyr  Val Ser Val Lys Glu  Ile Gly Gly Leu Thr  Gln Val Asn 
    1055                 1060                 1065             


Lys Asn  Lys Lys Trp Arg Glu  Leu Ala Thr Asn Leu  Asn Val Gly 
    1070                 1075                 1080             


Thr Ser  Ser Ser Ala Ala Ser  Ser Leu Lys Lys Gln  Tyr Ile Gln 
    1085                 1090                 1095             


Cys Leu  Tyr Ala Phe Glu Cys  Lys Ile Glu Arg Gly  Glu Asp Pro 
    1100                 1105                 1110             


Pro Pro  Asp Ile Phe Ala Ala  Ala Asp Ser Lys Lys  Ser Gln Pro 
    1115                 1120                 1125             


Lys Ile  Gln Pro Pro Ser Pro  Ala Gly Ser Gly Ser  Met Gln Gly 
    1130                 1135                 1140             


Pro Gln  Thr Pro Gln Ser Thr  Ser Ser Ser Met Ala  Glu Gly Gly 
    1145                 1150                 1155             


Asp Leu  Lys Pro Pro Thr Pro  Ala Ser Thr Pro His  Ser Gln Ile 
    1160                 1165                 1170             


Pro Pro  Leu Pro Gly Met Ser  Arg Ser Asn Ser Val  Gly Ile Gln 
    1175                 1180                 1185             


Asp Ala  Phe Asn Asp Gly Ser  Asp Ser Thr Phe Gln  Lys Arg Asn 
    1190                 1195                 1200             


Ser Met  Thr Pro Asn Pro Gly  Tyr Gln Pro Ser Met  Asn Thr Ser 
    1205                 1210                 1215             


Asp Met  Met Gly Arg Met Ser  Tyr Glu Pro Asn Lys  Asp Pro Tyr 
    1220                 1225                 1230             


Gly Ser  Met Arg Lys Ala Pro  Gly Ser Asp Pro Phe  Met Ser Ser 
    1235                 1240                 1245             


Gly Gln  Gly Pro Asn Gly Gly  Met Gly Asp Pro Tyr  Ser Arg Ala 
    1250                 1255                 1260             


Ala Gly  Pro Gly Leu Gly Asn  Val Ala Met Gly Pro  Arg Gln His 
    1265                 1270                 1275             


Tyr Pro  Tyr Gly Gly Pro Tyr  Asp Arg Val Arg Thr  Glu Pro Gly 
    1280                 1285                 1290             


Ile Gly  Pro Glu Gly Asn Met  Ser Thr Gly Ala Pro  Gln Pro Asn 
    1295                 1300                 1305             


Leu Met  Pro Ser Asn Pro Asp  Ser Gly Met Tyr Ser  Pro Ser Arg 
    1310                 1315                 1320             


Tyr Pro  Pro Gln Gln Gln Gln  Gln Gln Gln Gln Arg  His Asp Ser 
    1325                 1330                 1335             


Tyr Gly  Asn Gln Phe Ser Thr  Gln Gly Thr Pro Ser  Gly Ser Pro 
    1340                 1345                 1350             


Phe Pro  Ser Gln Gln Thr Thr  Met Tyr Gln Gln Gln  Gln Gln Asn 
    1355                 1360                 1365             


Tyr Lys  Arg Pro Met Asp Gly  Thr Tyr Gly Pro Pro  Ala Lys Arg 
    1370                 1375                 1380             


His Glu  Gly Glu Met Tyr Ser  Val Pro Tyr Ser Thr  Gly Gln Gly 
    1385                 1390                 1395             


Gln Pro  Gln Gln Gln Gln Leu  Pro Pro Ala Gln Pro  Gln Pro Ala 
    1400                 1405                 1410             


Ser Gln  Gln Gln Ala Ala Gln  Pro Ser Pro Gln Gln  Asp Val Tyr 
    1415                 1420                 1425             


Asn Gln  Tyr Gly Asn Ala Tyr  Pro Ala Thr Ala Thr  Ala Ala Thr 
    1430                 1435                 1440             


Glu Arg  Arg Pro Ala Gly Gly  Pro Gln Asn Gln Phe  Pro Phe Gln 
    1445                 1450                 1455             


Phe Gly  Arg Asp Arg Val Ser  Ala Pro Pro Gly Thr  Asn Ala Gln 
    1460                 1465                 1470             


Gln Asn  Met Pro Pro Gln Met  Met Gly Gly Pro Ile  Gln Ala Ser 
    1475                 1480                 1485             


Ala Glu  Val Ala Gln Gln Gly  Thr Met Trp Gln Gly  Arg Asn Asp 
    1490                 1495                 1500             


Met Thr  Tyr Asn Tyr Ala Asn  Arg Gln Ser Thr Gly  Ser Ala Pro 
    1505                 1510                 1515             


Gln Gly  Pro Ala Tyr His Gly  Val Asn Arg Thr Asp  Glu Met Leu 
    1520                 1525                 1530             


His Thr  Asp Gln Arg Ala Asn  His Glu Gly Ser Trp  Pro Ser His 
    1535                 1540                 1545             


Gly Thr  Arg Gln Pro Pro Tyr  Gly Pro Ser Ala Pro  Val Pro Pro 
    1550                 1555                 1560             


Met Thr  Arg Pro Pro Pro Ser  Asn Tyr Gln Pro Pro  Pro Ser Met 
    1565                 1570                 1575             


Gln Asn  His Ile Pro Gln Val  Ser Ser Pro Ala Pro  Leu Pro Arg 
    1580                 1585                 1590             


Pro Met  Glu Asn Arg Thr Ser  Pro Ser Lys Ser Pro  Phe Leu His 
    1595                 1600                 1605             


Ser Gly  Met Lys Met Gln Lys  Ala Gly Pro Pro Val  Pro Ala Ser 
    1610                 1615                 1620             


His Ile  Ala Pro Ala Pro Val  Gln Pro Pro Met Ile  Arg Arg Asp 
    1625                 1630                 1635             


Ile Thr  Phe Pro Pro Gly Ser  Val Glu Ala Thr Gln  Pro Val Leu 
    1640                 1645                 1650             


Lys Gln  Arg Arg Arg Leu Thr  Met Lys Asp Ile Gly  Thr Pro Glu 
    1655                 1660                 1665             


Ala Trp  Arg Val Met Met Ser  Leu Lys Ser Gly Leu  Leu Ala Glu 
    1670                 1675                 1680             


Ser Thr  Trp Ala Leu Asp Thr  Ile Asn Ile Leu Leu  Tyr Asp Asp 
    1685                 1690                 1695             


Asn Ser  Ile Met Thr Phe Asn  Leu Ser Gln Leu Pro  Gly Leu Leu 
    1700                 1705                 1710             


Glu Leu  Leu Val Glu Tyr Phe  Arg Arg Cys Leu Ile  Glu Ile Phe 
    1715                 1720                 1725             


Gly Ile  Leu Lys Glu Tyr Glu  Val Gly Asp Pro Gly  Gln Arg Thr 
    1730                 1735                 1740             


Leu Leu  Asp Pro Gly Arg Phe  Ser Lys Val Ser Ser  Pro Ala Pro 
    1745                 1750                 1755             


Met Glu  Gly Gly Glu Glu Glu  Glu Glu Leu Leu Gly  Pro Lys Leu 
    1760                 1765                 1770             


Glu Glu  Glu Glu Glu Glu Glu  Val Val Glu Asn Asp  Glu Glu Ile 
    1775                 1780                 1785             


Ala Phe  Ser Gly Lys Asp Lys  Pro Ala Ser Glu Asn  Ser Glu Glu 
    1790                 1795                 1800             


Lys Leu  Ile Ser Lys Phe Asp  Lys Leu Pro Val Lys  Ile Val Gln 
    1805                 1810                 1815             


Lys Asn  Asp Pro Phe Val Val  Asp Cys Ser Asp Lys  Leu Gly Arg 
    1820                 1825                 1830             


Val Gln  Glu Phe Asp Ser Gly  Leu Leu His Trp Arg  Ile Gly Gly 
    1835                 1840                 1845             


Gly Asp  Thr Thr Glu His Ile  Gln Thr His Phe Glu  Ser Lys Thr 
    1850                 1855                 1860             


Glu Leu  Leu Pro Ser Arg Pro  His Ala Pro Cys Pro  Pro Ala Pro 
    1865                 1870                 1875             


Arg Lys  His Val Thr Thr Ala  Glu Gly Thr Pro Gly  Thr Thr Asp 
    1880                 1885                 1890             


Gln Glu  Gly Pro Pro Pro Asp  Gly Pro Pro Glu Lys  Arg Ile Thr 
    1895                 1900                 1905             


Ala Thr  Met Asp Asp Met Leu  Ser Thr Arg Ser Ser  Thr Leu Thr 
    1910                 1915                 1920             


Glu Asp  Gly Ala Lys Ser Ser  Glu Ala Ile Lys Glu  Ser Ser Lys 
    1925                 1930                 1935             


Phe Pro  Phe Gly Ile Ser Pro  Ala Gln Ser His Arg  Asn Ile Lys 
    1940                 1945                 1950             


Ile Leu  Glu Asp Glu Pro His  Ser Lys Asp Glu Thr  Pro Leu Cys 
    1955                 1960                 1965             


Thr Leu  Leu Asp Trp Gln Asp  Ser Leu Ala Lys Arg  Cys Val Cys 
    1970                 1975                 1980             


Val Ser  Asn Thr Ile Arg Ser  Leu Ser Phe Val Pro  Gly Asn Asp 
    1985                 1990                 1995             


Phe Glu  Met Ser Lys His Pro  Gly Leu Leu Leu Ile  Leu Gly Lys 
    2000                 2005                 2010             


Leu Ile  Leu Leu His His Lys  His Pro Glu Arg Lys  Gln Ala Pro 
    2015                 2020                 2025             


Leu Thr  Tyr Glu Lys Glu Glu  Glu Gln Asp Gln Gly  Val Ser Cys 
    2030                 2035                 2040             


Asn Lys  Val Glu Trp Trp Trp  Asp Cys Leu Glu Met  Leu Arg Glu 
    2045                 2050                 2055             


Asn Thr  Leu Val Thr Leu Ala  Asn Ile Ser Gly Gln  Leu Asp Leu 
    2060                 2065                 2070             


Ser Pro  Tyr Pro Glu Ser Ile  Cys Leu Pro Val Leu  Asp Gly Leu 
    2075                 2080                 2085             


Leu His  Trp Ala Val Cys Pro  Ser Ala Glu Ala Gln  Asp Pro Phe 
    2090                 2095                 2100             


Ser Thr  Leu Gly Pro Asn Ala  Val Leu Ser Pro Gln  Arg Leu Val 
    2105                 2110                 2115             


Leu Glu  Thr Leu Ser Lys Leu  Ser Ile Gln Asp Asn  Asn Val Asp 
    2120                 2125                 2130             


Leu Ile  Leu Ala Thr Pro Pro  Phe Ser Arg Leu Glu  Lys Leu Tyr 
    2135                 2140                 2145             


Ser Thr  Met Val Arg Phe Leu  Ser Asp Arg Lys Asn  Pro Val Cys 
    2150                 2155                 2160             


Arg Glu  Met Ala Val Val Leu  Leu Ala Asn Leu Ala  Gln Gly Asp 
    2165                 2170                 2175             


Ser Leu  Ala Ala Arg Ala Ile  Ala Val Gln Lys Gly  Ser Ile Gly 
    2180                 2185                 2190             


Asn Leu  Leu Gly Phe Leu Glu  Asp Ser Leu Ala Ala  Thr Gln Phe 
    2195                 2200                 2205             


Gln Gln  Ser Gln Ala Ser Leu  Leu His Met Gln Asn  Pro Pro Phe 
    2210                 2215                 2220             


Glu Pro  Thr Ser Val Asp Met  Met Arg Arg Ala Ala  Arg Ala Leu 
    2225                 2230                 2235             


Leu Ala  Leu Ala Lys Val Asp  Glu Asn His Ser Glu  Phe Thr Leu 
    2240                 2245                 2250             


Tyr Glu  Ser Arg Leu Leu Asp  Ile Ser Val Ser Pro  Leu Met Asn 
    2255                 2260                 2265             


Ser Leu  Val Ser Gln Val Ile  Cys Asp Val Leu Phe  Leu Ile Gly 
    2270                 2275                 2280             


Gln Ser  
    2285 


<210> 48
<211> 7874
<212> DNA
<213> Homo sapiens

<400> 48
cagaaagcgg agagtcacag cggggccagg ccctggggag cggagcctcc accgcccccc       60

tcattcccag gcaagggctt ggggggaatg agccgggaga gccgggtccc gagcctacag      120

agccgggagc agctgagccg ccggcgcctc ggccgccgcc gccgcctcct cctcctccgc      180

cgccgccagc ccggagcctg agccggcggg gcggggggga gaggagcgag cgcagcgcag      240

cagcggagcc ccgcgaggcc cgcccgggcg ggtggggagg gcagcccggg ggactgggcc      300

ccggggcggg gtgggagggg gggagaagac gaagacaggg ccgggtctct ccgcggacga      360

gacagcgggg atcatggccg cgcaggtcgc ccccgccgcc gccagcagcc tgggcaaccc      420

gggcgaggcg gcggcggcgg cagcggccga gcgcggggaa atgaaggcag ccgccgggca      480

ggaaagcgag ggccccgccg tggggccgcc gcagccgctg ggaaaggagc tgcaggacgg      540

ggccgagagc aatgggggtg gcggcggcgg cggagccggc agcggcggcg ggcccggcgc      600

ggagccggac ctgaagaact cgaacgggaa cgcgggccct aggcccgccc tgaacaataa      660

cctcacggag ccgcccggcg gcggcggtgg cggcagcagc gatggggtgg gggcgcctcc      720

tcactcagcc gcggccgcct tgccgccccc agcctacggc ttcgggcaac cctacggccg      780

gagcccgtct gccgtcgccg ccgccgcggc cgccgtcttc caccaacaac atggcggaca      840

acaaagccct ggcctggcag cgctgcagag cggcggcggc gggggcctgg agccctacgc      900

ggggccccag cagaactctc acgaccacgg cttccccaac caccagtaca actcctacta      960

ccccaaccgc agcgcctacc ccccgcccgc cccggcctac gcgctgagct ccccgagagg     1020

tggcactccg ggctccggcg cggcggcggc tgccggctcc aagccgcctc cctcctccag     1080

cgcctccgcc tcctcgtcgt cttcgtcctt cgctcagcag cgcttcgggg ccatgggggg     1140

aggcggcccc tccgcggccg gcgggggaac tccccagccc accgccaccc ccaccctcaa     1200

ccaactgctc acgtcgccca gctcggcccg gggctaccag ggctaccccg ggggcgacta     1260

cagtggcggg ccccaggacg ggggcgccgg caagggcccg gcggacatgg cctcgcagtg     1320

ttggggggct gcggcggcgg cagctgcggc ggcggccgcc tcgggagggg cccaacaaag     1380

gagccaccac gcgcccatga gccccgggag cagcggcggc ggggggcagc cgctcgcccg     1440

gacccctcag ccatccagtc caatggatca gatgggcaag atgagacctc agccatatgg     1500

cgggactaac ccatactcgc agcaacaggg acctccgtca ggaccgcagc aaggacatgg     1560

gtacccaggg cagccatacg ggtcccagac cccgcagcgg tacccgatga ccatgcaggg     1620

ccgggcgcag agtgccatgg gcggcctctc ttatacacag cagattcctc cttatggaca     1680

acaaggcccc agcgggtatg gtcaacaggg ccagactcca tattacaacc agcaaagtcc     1740

tcaccctcag cagcagcagc caccctactc ccagcaacca ccgtcccaga cccctcatgc     1800

ccaaccttcg tatcagcagc agccacagtc tcaaccacca cagctccagt cctctcagcc     1860

tccatactcc cagcagccat cccagcctcc acatcagcag tccccggctc catacccctc     1920

ccagcagtcg acgacacagc agcaccccca gagccagccc ccctactcac agccacaggc     1980

tcagtctcct taccagcagc agcaacctca gcagccagca ccctcgacgc tctcccagca     2040

ggctgcgtat cctcagcccc agtctcagca gtcccagcaa actgcctatt cccagcagcg     2100

cttccctcca ccgcaggagc tatctcaaga ttcatttggg tctcaggcat cctcagcccc     2160

ctcaatgacc tccagtaagg gagggcaaga agatatgaac ctgagccttc agtcaagacc     2220

ctccagcttg cctgatctat ctggttcaat agatgacctc cccatgggga cagaaggagc     2280

tctgagtcct ggagtgagca catcagggat ttccagcagc caaggagagc agagtaatcc     2340

agctcagtct cctttctctc ctcatacctc ccctcacctg cctggcatcc gaggcccttc     2400

cccgtcccct gttggctctc ccgccagtgt tgctcagtct cgctcaggac cactctcgcc     2460

tgctgcagtg ccaggcaacc agatgccacc tcggccaccc agtggccagt cggacagcat     2520

catgcatcct tccatgaacc aatcaagcat tgcccaagat cgaggttata tgcagaggaa     2580

cccccagatg ccccagtaca gttcccccca gcccggctca gccttatctc cgcgtcagcc     2640

ttccggagga cagatacaca caggcatggg ctcctaccag cagaactcca tggggagcta     2700

tggtccccag gggggtcagt atggcccaca aggtggctac cccaggcagc caaactataa     2760

tgccttgccc aatgccaact accccagtgc aggcatggct ggaggcataa accccatggg     2820

tgccggaggt caaatgcatg gacagcctgg catcccacct tatggcacac tccctccagg     2880

gaggatgagt cacgcctcca tgggcaaccg gccttatggc cctaacatgg ccaatatgcc     2940

acctcaggtt gggtcaggga tgtgtccccc accagggggc atgaaccgga aaacccaaga     3000

aactgctgtc gccatgcatg ttgctgccaa ctctatccaa aacaggccgc caggctaccc     3060

caatatgaat caagggggca tgatgggaac tggacctcct tatggacaag ggattaatag     3120

tatggctggc atgatcaacc ctcagggacc cccatattcc atgggtggaa ccatggccaa     3180

caattctgca gggatggcag ccagcccaga gatgatgggc cttggggatg taaagttaac     3240

tccagccacc aaaatgaaca acaaggcaga tgggacaccc aagacagaat ccaaatccaa     3300

gaaatccagt tcttctacta caaccaatga gaagatcacc aagttgtatg agctgggtgg     3360

tgagcctgag aggaagatgt gggtggaccg ttatctggcc ttcactgagg agaaggccat     3420

gggcatgaca aatctgcctg ctgtgggtag gaaacctctg gacctctatc gcctctatgt     3480

gtctgtgaag gagattggtg gattgactca ggtcaacaag aacaaaaaat ggcgggaact     3540

tgcaaccaac ctcaatgtgg gcacatcaag cagtgctgcc agctccttga aaaagcagta     3600

tatccagtgt ctctatgcct ttgaatgcaa gattgaacgg ggagaagacc ctcccccaga     3660

catctttgca gctgctgatt ccaagaagtc ccagcccaag atccagcctc cctctcctgc     3720

gggatcagga tctatgcagg ggccccagac tccccagtca accagcagtt ccatggcaga     3780

aggaggagac ttaaagccac caactccagc atccacacca cacagtcaga tccccccatt     3840

gccaggcatg agcaggagca attcagttgg gatccaggat gcctttaatg atggaagtga     3900

ctccacattc cagaagcgga attccatgac tccaaaccct gggtatcagc ccagtatgaa     3960

tacctctgac atgatggggc gcatgtccta tgagccaaat aaggatcctt atggcagcat     4020

gaggaaagct ccagggagtg atcccttcat gtcctcaggg cagggcccca acggcgggat     4080

gggtgacccc tacagtcgtg ctgccggccc tgggctagga aatgtggcga tgggaccacg     4140

acagcactat ccctatggag gtccttatga cagagtgagg acggagcctg gaatagggcc     4200

tgagggaaac atgagcactg gggccccaca gccgaatctc atgccttcca acccagactc     4260

ggggatgtat tctcctagcc gctacccccc gcagcagcag cagcagcagc agcaacgaca     4320

tgattcctat ggcaatcagt tctccaccca aggcacccct tctggcagcc ccttccccag     4380

ccagcagact acaatgtatc aacagcaaca gcaggtatcc agccctgctc ccctgccccg     4440

gccaatggag aaccgcacct ctcctagcaa gtctccattc ctgcactctg ggatgaaaat     4500

gcagaaggca ggtcccccag tacctgcctc gcacatagca cctgcccctg tgcagccccc     4560

catgattcgg cgggatatca ccttcccacc tggctctgtt gaagccacac agcctgtgtt     4620

gaagcagagg aggcggctca caatgaaaga cattggaacc ccggaggcat ggcgggtaat     4680

gatgtccctc aagtctggtc tcctggcaga gagcacatgg gcattagata ccatcaacat     4740

cctgctgtat gatgacaaca gcatcatgac cttcaacctc agtcagctcc cagggttgct     4800

agagctcctt gtagaatatt tccgacgatg cctgattgag atctttggca ttttaaagga     4860

gtatgaggtg ggtgacccag gacagagaac gctactggat cctgggaggt tcagcaaggt     4920

gtctagtcca gctcccatgg agggtgggga agaagaagaa gaacttctag gtcctaaact     4980

agaagaggaa gaagaagagg aagtagttga aaatgatgag gagatagcct tttcaggcaa     5040

ggacaagcca gcttcagaga atagtgagga gaagctgatc agtaagtttg acaagcttcc     5100

agtaaagatc gtacagaaga atgatccatt tgtggtggac tgctcagata agcttgggcg     5160

tgtgcaggag tttgacagtg gcctgctgca ctggcggatt ggtggggggg acaccactga     5220

gcatatccag acccacttcg agagcaagac agagctgctg ccttcccggc ctcacgcacc     5280

ctgcccacca gcccctcgga agcatgtgac aacagcagag ggtacaccag ggacaacaga     5340

ccaggagggg cccccacctg atggacctcc agaaaaacgg atcacagcca ctatggatga     5400

catgttgtct actcggtcta gcaccttgac cgaggatgga gctaagagtt cagaggccat     5460

caaggagagc agcaagtttc catttggcat tagcccagca cagagccacc ggaacatcaa     5520

gatcctagag gacgaacccc acagtaagga tgagacccca ctgtgtaccc ttctggactg     5580

gcaggattct cttgccaagc gctgcgtctg tgtgtccaat accattcgaa gcctgtcatt     5640

tgtgccaggc aatgactttg agatgtccaa acacccaggg ctgctgctca tcctgggcaa     5700

gctgatcctg ctgcaccaca agcacccaga acggaagcag gcaccactaa cttatgaaaa     5760

ggaggaggaa caggaccaag gggtgagctg caacaaagtg gagtggtggt gggactgctt     5820

ggagatgctc cgggaaaaca ccttggttac actcgccaac atctcggggc agttggacct     5880

atctccatac cccgagagca tttgcctgcc tgtcctggac ggactcctac actgggcagt     5940

ttgcccttca gctgaagccc aggacccctt ttccaccctg ggccccaatg ccgtcctttc     6000

cccgcagaga ctggtcttgg aaaccctcag caaactcagc atccaggaca acaatgtgga     6060

cctgattctg gccacacccc ccttcagccg cctggagaag ttgtatagca ctatggtgcg     6120

cttcctcagt gaccgaaaga acccggtgtg ccgggagatg gctgtggtac tgctggccaa     6180

cctggctcag ggggacagcc tggcagctcg tgccattgca gtgcagaagg gcagtatcgg     6240

caacctcctg ggcttcctag aggacagcct tgccgccaca cagttccagc agagccaggc     6300

cagcctcctc cacatgcaga acccaccctt tgagccaact agtgtggaca tgatgcggcg     6360

ggctgcccgc gcgctgcttg ccttggccaa ggtggacgag aaccactcag agtttactct     6420

gtacgaatca cggctgttgg acatctcggt atcaccgttg atgaactcat tggtttcaca     6480

agtcatttgt gatgtactgt ttttgattgg ccagtcatga cagccgtggg acacctcccc     6540

cccccgtgtg tgtgtgcgtg tgtggagaac ttagaaactg actgttgccc tttatttatg     6600

caaaaccacc tcagaatcca gtttaccctg tgctgtccag cttctccctt gggaaaaagt     6660

ctctcctgtt tctctctcct ccttccacct cccctccctc catcacctca cgcctttctg     6720

ttccttgtcc tcaccttact cccctcagga ccctacccca ccctctttga aaagacaaag     6780

ctctgcctac atagaagact ttttttattt taaccaaagt tactgttgtt tacagtgagt     6840

ttggggaaaa aaaataaaat aaaaatggct ttcccagtcc ttgcatcaac gggatgccac     6900

atttcataac tgtttttaat ggtaaaaaaa aaaaaaaaaa atacaaaaaa aaattctgaa     6960

ggacaaaaaa ggtgactgct gaactgtgtg tggtttattg ttgtacattc acaatcttgc     7020

aggagccaag aagttcgcag ttgtgaacag accctgttca ctggagaggc ctgtgcagta     7080

gagtgtagac cctttcatgt actgtactgt acacctgata ctgtaaacat actgtaataa     7140

taatgtctca catggaaaca gaaaacgctg ggtcagcagc aagctgtagt ttttaaaaat     7200

gtttttagtt aaacgttgag gagaaaaaaa aaaaaggctt ttcccccaaa gtatcatgtg     7260

tgaacctaca acaccctgac ctctttctct cctccttgat tgtatgaata accctgagat     7320

cacctcttag aactggtttt aacctttagc tgcagcggct acgctgccac gtgtgtatat     7380

atatgacgtt gtacattgca catacccttg gatccccaca gtttggtcct cctcccagct     7440

acccctttat agtatgacga gttaacaagt tggtgacctg cacaaagcga gacacagcta     7500

tttaatctct tgccagatat cgcccctctt ggtgcgatgc tgtacaggtc tctgtaaaaa     7560

gtccttgctg tctcagcagc caatcaactt atagtttatt tttttctggg tttttgtttt     7620

gttttgtttt ctttctaatc gaggtgtgaa aaagttctag gttcagttga agttctgatg     7680

aagaaacaca attgagattt tttcagtgat aaaatctgca tatttgtatt tcaacaatgt     7740

agctaaaact tgatgtaaat tcctcctttt tttccttttt tggcttaatg aatatcattt     7800

attcagtatg aaatctttat actatatgtt ccacgtgtta agaataaatg tacattaaat     7860

cttggtaaga cttt                                                       7874


<210> 49
<211> 2068
<212> PRT
<213> Homo sapiens

<400> 49
Met Ala Ala Gln Val Ala Pro Ala Ala Ala Ser Ser Leu Gly Asn Pro 
1               5                   10                  15      


Pro Pro Pro Pro Pro Ser Glu Leu Lys Lys Ala Glu Gln Gln Gln Arg 
            20                  25                  30          


Glu Glu Ala Gly Gly Glu Ala Ala Ala Ala Ala Ala Ala Glu Arg Gly 
        35                  40                  45              


Glu Met Lys Ala Ala Ala Gly Gln Glu Ser Glu Gly Pro Ala Val Gly 
    50                  55                  60                  


Pro Pro Gln Pro Leu Gly Lys Glu Leu Gln Asp Gly Ala Glu Ser Asn 
65                  70                  75                  80  


Gly Gly Gly Gly Gly Gly Gly Ala Gly Ser Gly Gly Gly Pro Gly Ala 
                85                  90                  95      


Glu Pro Asp Leu Lys Asn Ser Asn Gly Asn Ala Gly Pro Arg Pro Ala 
            100                 105                 110         


Leu Asn Asn Asn Leu Thr Glu Pro Pro Gly Gly Gly Gly Gly Gly Ser 
        115                 120                 125             


Ser Asp Gly Val Gly Ala Pro Pro His Ser Ala Ala Ala Ala Leu Pro 
    130                 135                 140                 


Pro Pro Ala Tyr Gly Phe Gly Gln Pro Tyr Gly Arg Ser Pro Ser Ala 
145                 150                 155                 160 


Val Ala Ala Ala Ala Ala Ala Val Phe His Gln Gln His Gly Gly Gln 
                165                 170                 175     


Gln Ser Pro Gly Leu Ala Ala Leu Gln Ser Gly Gly Gly Gly Gly Leu 
            180                 185                 190         


Glu Pro Tyr Ala Gly Pro Gln Gln Asn Ser His Asp His Gly Phe Pro 
        195                 200                 205             


Asn His Gln Tyr Asn Ser Tyr Tyr Pro Asn Arg Ser Ala Tyr Pro Pro 
    210                 215                 220                 


Pro Ala Pro Ala Tyr Ala Leu Ser Ser Pro Arg Gly Gly Thr Pro Gly 
225                 230                 235                 240 


Ser Gly Ala Ala Ala Ala Ala Gly Ser Lys Pro Pro Pro Ser Ser Ser 
                245                 250                 255     


Ala Ser Ala Ser Ser Ser Ser Ser Ser Phe Ala Gln Gln Arg Phe Gly 
            260                 265                 270         


Ala Met Gly Gly Gly Gly Pro Ser Ala Ala Gly Gly Gly Thr Pro Gln 
        275                 280                 285             


Pro Thr Ala Thr Pro Thr Leu Asn Gln Leu Leu Thr Ser Pro Ser Ser 
    290                 295                 300                 


Ala Arg Gly Tyr Gln Gly Tyr Pro Gly Gly Asp Tyr Ser Gly Gly Pro 
305                 310                 315                 320 


Gln Asp Gly Gly Ala Gly Lys Gly Pro Ala Asp Met Ala Ser Gln Cys 
                325                 330                 335     


Trp Gly Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ser Gly Gly 
            340                 345                 350         


Ala Gln Gln Arg Ser His His Ala Pro Met Ser Pro Gly Ser Ser Gly 
        355                 360                 365             


Gly Gly Gly Gln Pro Leu Ala Arg Thr Pro Gln Pro Ser Ser Pro Met 
    370                 375                 380                 


Asp Gln Met Gly Lys Met Arg Pro Gln Pro Tyr Gly Gly Thr Asn Pro 
385                 390                 395                 400 


Tyr Ser Gln Gln Gln Gly Pro Pro Ser Gly Pro Gln Gln Gly His Gly 
                405                 410                 415     


Tyr Pro Gly Gln Pro Tyr Gly Ser Gln Thr Pro Gln Arg Tyr Pro Met 
            420                 425                 430         


Thr Met Gln Gly Arg Ala Gln Ser Ala Met Gly Gly Leu Ser Tyr Thr 
        435                 440                 445             


Gln Gln Ile Pro Pro Tyr Gly Gln Gln Gly Pro Ser Gly Tyr Gly Gln 
    450                 455                 460                 


Gln Gly Gln Thr Pro Tyr Tyr Asn Gln Gln Ser Pro His Pro Gln Gln 
465                 470                 475                 480 


Gln Gln Pro Pro Tyr Ser Gln Gln Pro Pro Ser Gln Thr Pro His Ala 
                485                 490                 495     


Gln Pro Ser Tyr Gln Gln Gln Pro Gln Ser Gln Pro Pro Gln Leu Gln 
            500                 505                 510         


Ser Ser Gln Pro Pro Tyr Ser Gln Gln Pro Ser Gln Pro Pro His Gln 
        515                 520                 525             


Gln Ser Pro Ala Pro Tyr Pro Ser Gln Gln Ser Thr Thr Gln Gln His 
    530                 535                 540                 


Pro Gln Ser Gln Pro Pro Tyr Ser Gln Pro Gln Ala Gln Ser Pro Tyr 
545                 550                 555                 560 


Gln Gln Gln Gln Pro Gln Gln Pro Ala Pro Ser Thr Leu Ser Gln Gln 
                565                 570                 575     


Ala Ala Tyr Pro Gln Pro Gln Ser Gln Gln Ser Gln Gln Thr Ala Tyr 
            580                 585                 590         


Ser Gln Gln Arg Phe Pro Pro Pro Gln Glu Leu Ser Gln Asp Ser Phe 
        595                 600                 605             


Gly Ser Gln Ala Ser Ser Ala Pro Ser Met Thr Ser Ser Lys Gly Gly 
    610                 615                 620                 


Gln Glu Asp Met Asn Leu Ser Leu Gln Ser Arg Pro Ser Ser Leu Pro 
625                 630                 635                 640 


Asp Leu Ser Gly Ser Ile Asp Asp Leu Pro Met Gly Thr Glu Gly Ala 
                645                 650                 655     


Leu Ser Pro Gly Val Ser Thr Ser Gly Ile Ser Ser Ser Gln Gly Glu 
            660                 665                 670         


Gln Ser Asn Pro Ala Gln Ser Pro Phe Ser Pro His Thr Ser Pro His 
        675                 680                 685             


Leu Pro Gly Ile Arg Gly Pro Ser Pro Ser Pro Val Gly Ser Pro Ala 
    690                 695                 700                 


Ser Val Ala Gln Ser Arg Ser Gly Pro Leu Ser Pro Ala Ala Val Pro 
705                 710                 715                 720 


Gly Asn Gln Met Pro Pro Arg Pro Pro Ser Gly Gln Ser Asp Ser Ile 
                725                 730                 735     


Met His Pro Ser Met Asn Gln Ser Ser Ile Ala Gln Asp Arg Gly Tyr 
            740                 745                 750         


Met Gln Arg Asn Pro Gln Met Pro Gln Tyr Ser Ser Pro Gln Pro Gly 
        755                 760                 765             


Ser Ala Leu Ser Pro Arg Gln Pro Ser Gly Gly Gln Ile His Thr Gly 
    770                 775                 780                 


Met Gly Ser Tyr Gln Gln Asn Ser Met Gly Ser Tyr Gly Pro Gln Gly 
785                 790                 795                 800 


Gly Gln Tyr Gly Pro Gln Gly Gly Tyr Pro Arg Gln Pro Asn Tyr Asn 
                805                 810                 815     


Ala Leu Pro Asn Ala Asn Tyr Pro Ser Ala Gly Met Ala Gly Gly Ile 
            820                 825                 830         


Asn Pro Met Gly Ala Gly Gly Gln Met His Gly Gln Pro Gly Ile Pro 
        835                 840                 845             


Pro Tyr Gly Thr Leu Pro Pro Gly Arg Met Ser His Ala Ser Met Gly 
    850                 855                 860                 


Asn Arg Pro Tyr Gly Pro Asn Met Ala Asn Met Pro Pro Gln Val Gly 
865                 870                 875                 880 


Ser Gly Met Cys Pro Pro Pro Gly Gly Met Asn Arg Lys Thr Gln Glu 
                885                 890                 895     


Thr Ala Val Ala Met His Val Ala Ala Asn Ser Ile Gln Asn Arg Pro 
            900                 905                 910         


Pro Gly Tyr Pro Asn Met Asn Gln Gly Gly Met Met Gly Thr Gly Pro 
        915                 920                 925             


Pro Tyr Gly Gln Gly Ile Asn Ser Met Ala Gly Met Ile Asn Pro Gln 
    930                 935                 940                 


Gly Pro Pro Tyr Ser Met Gly Gly Thr Met Ala Asn Asn Ser Ala Gly 
945                 950                 955                 960 


Met Ala Ala Ser Pro Glu Met Met Gly Leu Gly Asp Val Lys Leu Thr 
                965                 970                 975     


Pro Ala Thr Lys Met Asn Asn Lys Ala Asp Gly Thr Pro Lys Thr Glu 
            980                 985                 990         


Ser Lys Ser Lys Lys Ser Ser Ser  Ser Thr Thr Thr Asn  Glu Lys Ile 
        995                 1000                 1005             


Thr Lys  Leu Tyr Glu Leu Gly  Gly Glu Pro Glu Arg  Lys Met Trp 
    1010                 1015                 1020             


Val Asp  Arg Tyr Leu Ala Phe  Thr Glu Glu Lys Ala  Met Gly Met 
    1025                 1030                 1035             


Thr Asn  Leu Pro Ala Val Gly  Arg Lys Pro Leu Asp  Leu Tyr Arg 
    1040                 1045                 1050             


Leu Tyr  Val Ser Val Lys Glu  Ile Gly Gly Leu Thr  Gln Val Asn 
    1055                 1060                 1065             


Lys Asn  Lys Lys Trp Arg Glu  Leu Ala Thr Asn Leu  Asn Val Gly 
    1070                 1075                 1080             


Thr Ser  Ser Ser Ala Ala Ser  Ser Leu Lys Lys Gln  Tyr Ile Gln 
    1085                 1090                 1095             


Cys Leu  Tyr Ala Phe Glu Cys  Lys Ile Glu Arg Gly  Glu Asp Pro 
    1100                 1105                 1110             


Pro Pro  Asp Ile Phe Ala Ala  Ala Asp Ser Lys Lys  Ser Gln Pro 
    1115                 1120                 1125             


Lys Ile  Gln Pro Pro Ser Pro  Ala Gly Ser Gly Ser  Met Gln Gly 
    1130                 1135                 1140             


Pro Gln  Thr Pro Gln Ser Thr  Ser Ser Ser Met Ala  Glu Gly Gly 
    1145                 1150                 1155             


Asp Leu  Lys Pro Pro Thr Pro  Ala Ser Thr Pro His  Ser Gln Ile 
    1160                 1165                 1170             


Pro Pro  Leu Pro Gly Met Ser  Arg Ser Asn Ser Val  Gly Ile Gln 
    1175                 1180                 1185             


Asp Ala  Phe Asn Asp Gly Ser  Asp Ser Thr Phe Gln  Lys Arg Asn 
    1190                 1195                 1200             


Ser Met  Thr Pro Asn Pro Gly  Tyr Gln Pro Ser Met  Asn Thr Ser 
    1205                 1210                 1215             


Asp Met  Met Gly Arg Met Ser  Tyr Glu Pro Asn Lys  Asp Pro Tyr 
    1220                 1225                 1230             


Gly Ser  Met Arg Lys Ala Pro  Gly Ser Asp Pro Phe  Met Ser Ser 
    1235                 1240                 1245             


Gly Gln  Gly Pro Asn Gly Gly  Met Gly Asp Pro Tyr  Ser Arg Ala 
    1250                 1255                 1260             


Ala Gly  Pro Gly Leu Gly Asn  Val Ala Met Gly Pro  Arg Gln His 
    1265                 1270                 1275             


Tyr Pro  Tyr Gly Gly Pro Tyr  Asp Arg Val Arg Thr  Glu Pro Gly 
    1280                 1285                 1290             


Ile Gly  Pro Glu Gly Asn Met  Ser Thr Gly Ala Pro  Gln Pro Asn 
    1295                 1300                 1305             


Leu Met  Pro Ser Asn Pro Asp  Ser Gly Met Tyr Ser  Pro Ser Arg 
    1310                 1315                 1320             


Tyr Pro  Pro Gln Gln Gln Gln  Gln Gln Gln Gln Arg  His Asp Ser 
    1325                 1330                 1335             


Tyr Gly  Asn Gln Phe Ser Thr  Gln Gly Thr Pro Ser  Gly Ser Pro 
    1340                 1345                 1350             


Phe Pro  Ser Gln Gln Thr Thr  Met Tyr Gln Gln Gln  Gln Gln Val 
    1355                 1360                 1365             


Ser Ser  Pro Ala Pro Leu Pro  Arg Pro Met Glu Asn  Arg Thr Ser 
    1370                 1375                 1380             


Pro Ser  Lys Ser Pro Phe Leu  His Ser Gly Met Lys  Met Gln Lys 
    1385                 1390                 1395             


Ala Gly  Pro Pro Val Pro Ala  Ser His Ile Ala Pro  Ala Pro Val 
    1400                 1405                 1410             


Gln Pro  Pro Met Ile Arg Arg  Asp Ile Thr Phe Pro  Pro Gly Ser 
    1415                 1420                 1425             


Val Glu  Ala Thr Gln Pro Val  Leu Lys Gln Arg Arg  Arg Leu Thr 
    1430                 1435                 1440             


Met Lys  Asp Ile Gly Thr Pro  Glu Ala Trp Arg Val  Met Met Ser 
    1445                 1450                 1455             


Leu Lys  Ser Gly Leu Leu Ala  Glu Ser Thr Trp Ala  Leu Asp Thr 
    1460                 1465                 1470             


Ile Asn  Ile Leu Leu Tyr Asp  Asp Asn Ser Ile Met  Thr Phe Asn 
    1475                 1480                 1485             


Leu Ser  Gln Leu Pro Gly Leu  Leu Glu Leu Leu Val  Glu Tyr Phe 
    1490                 1495                 1500             


Arg Arg  Cys Leu Ile Glu Ile  Phe Gly Ile Leu Lys  Glu Tyr Glu 
    1505                 1510                 1515             


Val Gly  Asp Pro Gly Gln Arg  Thr Leu Leu Asp Pro  Gly Arg Phe 
    1520                 1525                 1530             


Ser Lys  Val Ser Ser Pro Ala  Pro Met Glu Gly Gly  Glu Glu Glu 
    1535                 1540                 1545             


Glu Glu  Leu Leu Gly Pro Lys  Leu Glu Glu Glu Glu  Glu Glu Glu 
    1550                 1555                 1560             


Val Val  Glu Asn Asp Glu Glu  Ile Ala Phe Ser Gly  Lys Asp Lys 
    1565                 1570                 1575             


Pro Ala  Ser Glu Asn Ser Glu  Glu Lys Leu Ile Ser  Lys Phe Asp 
    1580                 1585                 1590             


Lys Leu  Pro Val Lys Ile Val  Gln Lys Asn Asp Pro  Phe Val Val 
    1595                 1600                 1605             


Asp Cys  Ser Asp Lys Leu Gly  Arg Val Gln Glu Phe  Asp Ser Gly 
    1610                 1615                 1620             


Leu Leu  His Trp Arg Ile Gly  Gly Gly Asp Thr Thr  Glu His Ile 
    1625                 1630                 1635             


Gln Thr  His Phe Glu Ser Lys  Thr Glu Leu Leu Pro  Ser Arg Pro 
    1640                 1645                 1650             


His Ala  Pro Cys Pro Pro Ala  Pro Arg Lys His Val  Thr Thr Ala 
    1655                 1660                 1665             


Glu Gly  Thr Pro Gly Thr Thr  Asp Gln Glu Gly Pro  Pro Pro Asp 
    1670                 1675                 1680             


Gly Pro  Pro Glu Lys Arg Ile  Thr Ala Thr Met Asp  Asp Met Leu 
    1685                 1690                 1695             


Ser Thr  Arg Ser Ser Thr Leu  Thr Glu Asp Gly Ala  Lys Ser Ser 
    1700                 1705                 1710             


Glu Ala  Ile Lys Glu Ser Ser  Lys Phe Pro Phe Gly  Ile Ser Pro 
    1715                 1720                 1725             


Ala Gln  Ser His Arg Asn Ile  Lys Ile Leu Glu Asp  Glu Pro His 
    1730                 1735                 1740             


Ser Lys  Asp Glu Thr Pro Leu  Cys Thr Leu Leu Asp  Trp Gln Asp 
    1745                 1750                 1755             


Ser Leu  Ala Lys Arg Cys Val  Cys Val Ser Asn Thr  Ile Arg Ser 
    1760                 1765                 1770             


Leu Ser  Phe Val Pro Gly Asn  Asp Phe Glu Met Ser  Lys His Pro 
    1775                 1780                 1785             


Gly Leu  Leu Leu Ile Leu Gly  Lys Leu Ile Leu Leu  His His Lys 
    1790                 1795                 1800             


His Pro  Glu Arg Lys Gln Ala  Pro Leu Thr Tyr Glu  Lys Glu Glu 
    1805                 1810                 1815             


Glu Gln  Asp Gln Gly Val Ser  Cys Asn Lys Val Glu  Trp Trp Trp 
    1820                 1825                 1830             


Asp Cys  Leu Glu Met Leu Arg  Glu Asn Thr Leu Val  Thr Leu Ala 
    1835                 1840                 1845             


Asn Ile  Ser Gly Gln Leu Asp  Leu Ser Pro Tyr Pro  Glu Ser Ile 
    1850                 1855                 1860             


Cys Leu  Pro Val Leu Asp Gly  Leu Leu His Trp Ala  Val Cys Pro 
    1865                 1870                 1875             


Ser Ala  Glu Ala Gln Asp Pro  Phe Ser Thr Leu Gly  Pro Asn Ala 
    1880                 1885                 1890             


Val Leu  Ser Pro Gln Arg Leu  Val Leu Glu Thr Leu  Ser Lys Leu 
    1895                 1900                 1905             


Ser Ile  Gln Asp Asn Asn Val  Asp Leu Ile Leu Ala  Thr Pro Pro 
    1910                 1915                 1920             


Phe Ser  Arg Leu Glu Lys Leu  Tyr Ser Thr Met Val  Arg Phe Leu 
    1925                 1930                 1935             


Ser Asp  Arg Lys Asn Pro Val  Cys Arg Glu Met Ala  Val Val Leu 
    1940                 1945                 1950             


Leu Ala  Asn Leu Ala Gln Gly  Asp Ser Leu Ala Ala  Arg Ala Ile 
    1955                 1960                 1965             


Ala Val  Gln Lys Gly Ser Ile  Gly Asn Leu Leu Gly  Phe Leu Glu 
    1970                 1975                 1980             


Asp Ser  Leu Ala Ala Thr Gln  Phe Gln Gln Ser Gln  Ala Ser Leu 
    1985                 1990                 1995             


Leu His  Met Gln Asn Pro Pro  Phe Glu Pro Thr Ser  Val Asp Met 
    2000                 2005                 2010             


Met Arg  Arg Ala Ala Arg Ala  Leu Leu Ala Leu Ala  Lys Val Asp 
    2015                 2020                 2025             


Glu Asn  His Ser Glu Phe Thr  Leu Tyr Glu Ser Arg  Leu Leu Asp 
    2030                 2035                 2040             


Ile Ser  Val Ser Pro Leu Met  Asn Ser Leu Val Ser  Gln Val Ile 
    2045                 2050                 2055             


Cys Asp  Val Leu Phe Leu Ile  Gly Gln Ser 
    2060                 2065             


<210> 50
<211> 8175
<212> DNA
<213> Mus musculus

<400> 50
atggccgcgc aggtcgcccc cgccgccgcc agcagcctgg gcaacccgcc gccgccgccc       60

tcggagctga agaaagccga gcagcaacag cgggaggagg cggggggcga ggcggcggcg      120

gcagcggccg agcgcgggga aatgaaggca gccgccgggc aggagagcga gggccccgcc      180

gtggggccgc cgcagccgct gggaaaggag ctgcaggacg gggccgagag caatgggggt      240

ggcggcggcg gcggagccgg cagcggcggc gggcccggcg cggagccgga cctgaagaac      300

tcgaacggga acgcgggccc taggcccgcc ctgaacaata acctcccgga gccgcccggc      360

ggcggcggcg gcggcggcag cagcagcagc gacggggtgg gggcgcctcc tcactcggcc      420

gcggccgccc tgccgccccc agcctacggc ttcgggcaag cctacggccg gagcccgtct      480

gccgtcgccg ccgcggcggc cgccgtcttc caccaacaac atggcggaca acaaagccct      540

ggcctggcag cgctgcagag cggcggcggc gggggcttgg agccctacgc cgggccccag      600

cagaactcgc acgaccacgg cttccccaac caccagtaca actcctacta ccccaaccgc      660

agcgcctacc ccccgcctcc ccaggcctac gcgctgagct ccccgagagg tggcactccg      720

ggctccggcg cggcggcggc cgccggctcc aagccgcctc cctcctccag cgcctctgcc      780

tcctcgtcgt cttcgtcctt cgcacagcag cgcttcgggg ccatgggggg aggcggcccc      840

tcagcggccg gcgggggaac tccccagccc accgccaccc ccaccctcaa ccaactgctc      900

acgtcgccca gctcggcccg tggctaccag ggctaccccg ggggcgacta cggcggcggg      960

ccccaggacg ggggcgcggg caaaggcccg gcggacatgg cctcgcagtg ctggggggct     1020

gcggcggcgg cggcggcggc ggcagcggcc gtctcgggag gggcccaaca aaggagccac     1080

cacgcgccca tgagccccgg gagcagcggc ggcggggggc agccgctcgc ccggacccct     1140

cagtcatcca gtccaatgga tcagatggga aagatgagac ctcagccgta tggtgggact     1200

aacccatact cgcaacaaca gggacctcct tcaggaccgc aacaaggaca tgggtaccca     1260

gggcagccat atgggtccca gactccacag cggtacccca tgaccatgca gggccgggct     1320

cagagtgcca tgggcagcct ctcttatgca cagcagattc caccttatgg ccagcaaggc     1380

cccagtgcgt atggccagca gggccagact ccatactata accagcaaag tcctcatccc     1440

cagcagcagc caccttacgc ccagcaacca ccatcccaga cccctcatgc ccagccttcg     1500

tatcagcagc agccgcagac tcagcaacca cagcttcagt cctctcagcc tccatattcc     1560

cagcagccat cccagcctcc acatcagcag tccccaactc catatccctc ccagcagtcc     1620

accacacaac agcatcccca gagccagccc ccctactcac aaccacaggc acagtctccc     1680

taccagcagc agcaacctca gcagccagca tcctcgtcgc tctcccagca ggctgcatat     1740

cctcagcccc agcctcagca gtcccagcaa actgcctatt cccagcagcg cttccctcca     1800

ccacaggagc tttctcaaga ttcatttggg tctcaggcat cctcagcccc ctcaatgacc     1860

tccagtaagg gagggcaaga agatatgaac ctgagtcttc agtcaaggcc ctccagcttg     1920

cctgatctgt ctggttcaat cgatgatctc cccatgggga cagaaggagc tctgagtcct     1980

ggcgtgagca catcagggat ttccagcagc caaggagagc agagcaatcc agctcagtct     2040

cccttttctc ctcacacctc ccctcacctg cctggcatcc gaggcccgtc cccgtcccct     2100

gttggctctc ctgccagtgt cgcgcagtct cgctcaggac cactctcgcc tgctgcagtg     2160

ccaggcaacc agatgccacc tcggccaccc agtggccagt cagacagcat catgcaccct     2220

tccatgaacc aatcaagcat tgcccaagat cgaggttata tgcagaggaa cccccagatg     2280

ccccagtaca cttcccctca gcctggctcg gccttatccc cacgtcagcc gtctggagga     2340

cagatgcact cgggcgtggg ctcctaccag cagaactcca tggggagcta cggcccccag     2400

ggcagtcagt atggcccaca aggaggctat cctaggcagc ctaactataa tgccttgccc     2460

aacgccaact accccaatgc aggcatggcc ggaagtatga accctatggg tgctggaggt     2520

cagatgcatg ggcagcctgg aatcccacct tacggcacac tccctccagg gagaatggct     2580

catgcgtcta tgggcaacag gccctatggc cctaatatgg ccaatatgcc acctcaggtt     2640

gggtcaggga tgtgtcctcc accaggggga atgaacagga aaactcaaga gtctgctgtt     2700

gccatgcatg ttgctgccaa ctctatccaa aacaggccac caggctaccc aaatatgaat     2760

caagggggca tgatgggaac tggacctccc tatggacagg ggatcaatag tatggctggc     2820

atgatcaacc ctcagggacc cccatatcct atgggtggaa ccatggccaa caattcagca     2880

gggatggcag ccagcccaga gatgatgggc cttggggatg ttaagttaac tcccgccaca     2940

aaaatgaaca acaaggcaga tggaacaccc aagacagaat ccaaatctaa gaaatccagt     3000

tcttctacca ccaccaatga gaagatcacc aaattgtatg agttgggtgg tgagcccgag     3060

aggaagatgt gggtggaccg gtacctggcc ttcacagagg agaaggccat gggcatgaca     3120

aatctgcctg ctgtggggag gaagcctctg gacctctatc gcctctatgt gtctgtgaag     3180

gagattggtg ggttgactca ggtcaacaag aacaaaaaat ggcgggaact tgcaaccaac     3240

ctcaatgtgg gtacatcaag cagtgctgcc agctcactga aaaagcagta tatccaatgt     3300

ctctatgcct ttgagtgcaa gatcgagcgt ggagaagacc ctccccccga tatcttcgca     3360

gctgctgact ccaagaagtc ccaacccaag atccagcccc cctctcctgc gggatcaggg     3420

tctatgcagg ggccacaaac tcctcagtca accagcagtt ctatggcaga aggaggagac     3480

ctgaagccac caactccagc atccacacca catagtcaaa ttcccccctt accaggcatg     3540

agcaggagca actcagtcgg aatccaggat gcctttcctg atggaagtga ccccacattc     3600

cagaagcgga attccatgac tccaaaccct gggtaccagc ccagtatgaa tacctctgac     3660

atgatggggc gcatgtccta tgagccaaat aaggatcctt atggcagcat gaggaaagcg     3720

ccaggaagtg atcccttcat gtcctcaggg cagggcccca atggcgggat gggtgatccc     3780

tacagccgtg ctgctggccc tgggctggga agtgtggcga tgggaccacg gcagcactat     3840

ccctatggag gtccttacga cagagtgagg acggagcctg gaatcgggcc tgaaggaaat     3900

atgggcactg gagcccctca gccaaatctc atgccttcca ccccagattc ggggatgtat     3960

tctcctagcc gctacccccc gcagcagcag cagcaacagc agcaacaaca tgattcctat     4020

ggcaatcaat tctctaccca aggcacccct tccagcagcc ccttccccag ccagcagacc     4080

acaatgtatc agcagcagca gcagaattat aagaggccaa tggatggcac atatggcccc     4140

cctgccaagc ggcatgaagg ggagatgtac agtgtgccgt acagcgctgg gcaaggccag     4200

cctcaacagc agcagttgcc tgcagctcag tcccagcctg ccagccagcc acaagctgcc     4260

cagccttccc ctcagcagga cgtgtacaac cagtacagca atgcctaccc tgcctccgcc     4320

accgctgcta ctgatcgccg accagcaggc ggcccccaga accaatttcc attccagttt     4380

ggccgagacc gagtctctgc acctcctggt tccagtgccc agcagaacat gccaccacaa     4440

atgatgggtg gccccataca ggcatcagct gaggttgctc agcagggcac catgtggcag     4500

gggcgaaatg acatgaccta caattatgcc aacaggcaga acacaggctc tgccacccag     4560

ggccctgcgt atcatggtgt gaaccgaaca gatgaaatgc tccacacaga tcagagggcc     4620

aaccatgaag gcccatggcc ttcccatggc acacgccagc ctccgtatgg tccttcagcc     4680

cctgttcccc ccatgacaag gccccctcca tctaactacc agcccccacc aagcatgccg     4740

aatcacattc ctcaggtatc cagccccgct cccctccccc ggcccatgga gaaccgtact     4800

tctcctagca agtctccatt cctgcactct gggatgaaaa tgcaaaaggc gggtccaccg     4860

gtgcctgctt cgcacatagc gcctacccct gtgcagccgc ctatgattcg gcgggatatc     4920

accttcccac ctggctctgt agaggccact cagcctgtgt tgaagcagag aaggcggctc     4980

acaatgaaag acattggaac cccggaggca tggcgggtaa tgatgtccct caagtccggg     5040

ctcctggcag agagcacgtg ggcgttagac accattaaca ttctactgta tgatgacaac     5100

agcattatga ccttcaacct cagccagctc ccaggcttgc tagagctcct tgtggaatat     5160

ttccgtagat gcctaattga aatctttggc attttaaagg agtatgaggt aggggaccca     5220

ggacagagaa cattactaga ccctgggaga ttcaccaagg tgtatagtcc agcccataca     5280

gaggaagaag aggaagaaca ccttgatcct aaactggagg aggaagagga agaaggggtt     5340

ggaaatgatg aggagatggc ctttttgggc aaggacaagc catcttcaga gaataatgag     5400

gagaagctag tcagtaagtt tgacaagctt ccggtaaaga tcgtgcagag gaatgaccca     5460

tttgtggtgg actgctcaga taagcttggg cgcgtgcagg agtttgacag tggcctgcta     5520

cactggcgga ttggtggtgg ggataccact gagcatatcc agacccactt tgagagcaag     5580

atagagctgc tgccttcccg gccttatgtg ccctgcccaa cgccccctcg gaaacacctc     5640

acaacagtag agggcacacc agggacaacg gagcaggagg gccccccgcc cgatggcctt     5700

ccagagaaaa ggatcacagc caccatggat gacatgttgt ctacccggtc tagcacattg     5760

actgatgagg gggcaaagag tgcagaggcc accaaggaaa gcagcaagtt tccatttggc     5820

attagcccag cacagagcca ccggaacatc aaaattttag aggatgaacc ccatagtaag     5880

gatgagaccc cactgtgtac ccttctggac tggcaggatt cccttgctaa gcgctgtgtc     5940

tgtgtctcca ataccatccg gagcctgtcg tttgtgccag gcaacgactt tgagatgtcc     6000

aaacacccag ggctgctgct tatcctgggc aagctgatcc tgctgcacca caagcaccca     6060

gagcggaagc aggcaccact aacttatgag aaggaggagg aacaggacca aggggtgagc     6120

tgtgacaaag tggagtggtg gtgggactgc ttggagatgc tccgagaaaa cacgctggtc     6180

accctcgcca acatctcggg gcaattggac ctatccccat atcctgagag catctgcctg     6240

cctgtcctgg acggactcct acactgggca gtttgccctt cagctgaagc ccaggacccc     6300

ttctcaaccc taggccccaa tgccgtcctc tccccccaga gattggtctt ggaaaccctc     6360

agcaaactca gcatccagga caacaatgtg gacctgatcc tggccactcc cccttttagc     6420

cgcctggaga agttgtatag taccatggtg cgcttcctca gtgaccgaaa gaacccagtg     6480

tgccgggaga tggccgtggt actgctggca aatctggccc agggggacag cctggcagcc     6540

cgggccattg cagtgcagaa gggcagcatc ggcaacctcc tgggtttcct ggaggacagc     6600

cttgctgcca cacagttcca gcagagccag gcaagcctcc tgcatatgca gaatccaccc     6660

tttgaaccaa ctagtgtgga catgatgcgg cgggctgccc gagcactgct tgccctggcc     6720

aaggtggatg agaaccactc agagttcact ctgtatgagt cacggctgtt ggacatctcc     6780

gtgtcaccac tgatgaactc attggtttca caagtcattt gtgatgtact gtttttgatt     6840

ggccagtcat gacagccgtg ggacacctcc cctccccgtg tgtgtgtgag tgtgtggaga     6900

acttagaaac tgactgttgc cctttattta tgcaaaacca cctcagaatc cagtttaccc     6960

tgtgctgtcc agcttctccc ttgggaaagc ctctcctgtt ctctctcctc cccaccctca     7020

ctccctcaca cctttctgtt ccccatcctc acctgcttcc ctcaggaccc caccctattt     7080

gaaaagacaa agctctgcct acatagaaga cttttttatt ttaaccaaag ttactgttgt     7140

ttacagtgag tttggggaaa aaaatggctt tcccagtcct tgcatcaacg ggatgccaca     7200

tttcataact gtttttaatg gttaaaaaaa aaaaaaaaaa aaggaaaaaa aatacaaaaa     7260

aaccctgaag gacaaaggtg actgctgagc tgtgtggttt gtcgctgtcc attcacaatc     7320

tcgcaggagc cgagaagttc gcagttgtga gcagaccctg ttcactggag aggcctgtgc     7380

agtagagtgt agatcctttc atgtactgta ctgtacacct gatactgtaa acatactgta     7440

ataataatgt ctcacatgga aacgagagaa gacgctgggt cagcagcaag ctgtagtttt     7500

taaaaatgtt tttagttaaa tgttgaggag aaaaaaaatg gctttccccc caaagtatcc     7560

tgtgtgaacc tacaacgccc tgacctcttt ctctcctcct tgattgtatg aatagccctg     7620

agatcacctc ttagacctgg ttttaacctt tagctgcagc ggctgcgctg ccacgtgtgt     7680

atatatatga tgttgtacat tgcacatacc cttgaatctc cacagtttgg tccccttccc     7740

agctacccct ttatagtatg gcgagttaac aagttggtga cctgcacaaa gcgagacaca     7800

gctatttaat ctcttgccag acattgcccc tcttggtgca gtgctctaca ggtctctgta     7860

aaaagccctt gctgtctcag cagccaatca acttacagtt tatttttttc tgggtttttg     7920

ttttgttttg tttcatttct aatcgaggtg tgaaaaagtt ctaggttcag ttgaagttcc     7980

tgatgaagaa acacaattga gattttttca gtgataaaat ctgcatattt gtatttcaac     8040

aatgtagcta aaaacttgat gtaaattcct cctttttttt ccttttttgg cttaatgaat     8100

atcatttatt cagtatgaaa tctttatact atatgttcca cgtgttaaga ataaatgtac     8160

attaaatctt ggtaa                                                      8175


<210> 51
<211> 2283
<212> PRT
<213> Mus musculus

<400> 51
Met Ala Ala Gln Val Ala Pro Ala Ala Ala Ser Ser Leu Gly Asn Pro 
1               5                   10                  15      


Pro Pro Pro Pro Ser Glu Leu Lys Lys Ala Glu Gln Gln Gln Arg Glu 
            20                  25                  30          


Glu Ala Gly Gly Glu Ala Ala Ala Ala Ala Ala Glu Arg Gly Glu Met 
        35                  40                  45              


Lys Ala Ala Ala Gly Gln Glu Ser Glu Gly Pro Ala Val Gly Pro Pro 
    50                  55                  60                  


Gln Pro Leu Gly Lys Glu Leu Gln Asp Gly Ala Glu Ser Asn Gly Gly 
65                  70                  75                  80  


Gly Gly Gly Gly Gly Ala Gly Ser Gly Gly Gly Pro Gly Ala Glu Pro 
                85                  90                  95      


Asp Leu Lys Asn Ser Asn Gly Asn Ala Gly Pro Arg Pro Ala Leu Asn 
            100                 105                 110         


Asn Asn Leu Pro Glu Pro Pro Gly Gly Gly Gly Gly Gly Gly Ser Ser 
        115                 120                 125             


Ser Ser Asp Gly Val Gly Ala Pro Pro His Ser Ala Ala Ala Ala Leu 
    130                 135                 140                 


Pro Pro Pro Ala Tyr Gly Phe Gly Gln Ala Tyr Gly Arg Ser Pro Ser 
145                 150                 155                 160 


Ala Val Ala Ala Ala Ala Ala Ala Val Phe His Gln Gln His Gly Gly 
                165                 170                 175     


Gln Gln Ser Pro Gly Leu Ala Ala Leu Gln Ser Gly Gly Gly Gly Gly 
            180                 185                 190         


Leu Glu Pro Tyr Ala Gly Pro Gln Gln Asn Ser His Asp His Gly Phe 
        195                 200                 205             


Pro Asn His Gln Tyr Asn Ser Tyr Tyr Pro Asn Arg Ser Ala Tyr Pro 
    210                 215                 220                 


Pro Pro Pro Gln Ala Tyr Ala Leu Ser Ser Pro Arg Gly Gly Thr Pro 
225                 230                 235                 240 


Gly Ser Gly Ala Ala Ala Ala Ala Gly Ser Lys Pro Pro Pro Ser Ser 
                245                 250                 255     


Ser Ala Ser Ala Ser Ser Ser Ser Ser Ser Phe Ala Gln Gln Arg Phe 
            260                 265                 270         


Gly Ala Met Gly Gly Gly Gly Pro Ser Ala Ala Gly Gly Gly Thr Pro 
        275                 280                 285             


Gln Pro Thr Ala Thr Pro Thr Leu Asn Gln Leu Leu Thr Ser Pro Ser 
    290                 295                 300                 


Ser Ala Arg Gly Tyr Gln Gly Tyr Pro Gly Gly Asp Tyr Gly Gly Gly 
305                 310                 315                 320 


Pro Gln Asp Gly Gly Ala Gly Lys Gly Pro Ala Asp Met Ala Ser Gln 
                325                 330                 335     


Cys Trp Gly Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Val Ser 
            340                 345                 350         


Gly Gly Ala Gln Gln Arg Ser His His Ala Pro Met Ser Pro Gly Ser 
        355                 360                 365             


Ser Gly Gly Gly Gly Gln Pro Leu Ala Arg Thr Pro Gln Ser Ser Ser 
    370                 375                 380                 


Pro Met Asp Gln Met Gly Lys Met Arg Pro Gln Pro Tyr Gly Gly Thr 
385                 390                 395                 400 


Asn Pro Tyr Ser Gln Gln Gln Gly Pro Pro Ser Gly Pro Gln Gln Gly 
                405                 410                 415     


His Gly Tyr Pro Gly Gln Pro Tyr Gly Ser Gln Thr Pro Gln Arg Tyr 
            420                 425                 430         


Pro Met Thr Met Gln Gly Arg Ala Gln Ser Ala Met Gly Ser Leu Ser 
        435                 440                 445             


Tyr Ala Gln Gln Ile Pro Pro Tyr Gly Gln Gln Gly Pro Ser Ala Tyr 
    450                 455                 460                 


Gly Gln Gln Gly Gln Thr Pro Tyr Tyr Asn Gln Gln Ser Pro His Pro 
465                 470                 475                 480 


Gln Gln Gln Pro Pro Tyr Ala Gln Gln Pro Pro Ser Gln Thr Pro His 
                485                 490                 495     


Ala Gln Pro Ser Tyr Gln Gln Gln Pro Gln Thr Gln Gln Pro Gln Leu 
            500                 505                 510         


Gln Ser Ser Gln Pro Pro Tyr Ser Gln Gln Pro Ser Gln Pro Pro His 
        515                 520                 525             


Gln Gln Ser Pro Thr Pro Tyr Pro Ser Gln Gln Ser Thr Thr Gln Gln 
    530                 535                 540                 


His Pro Gln Ser Gln Pro Pro Tyr Ser Gln Pro Gln Ala Gln Ser Pro 
545                 550                 555                 560 


Tyr Gln Gln Gln Gln Pro Gln Gln Pro Ala Ser Ser Ser Leu Ser Gln 
                565                 570                 575     


Gln Ala Ala Tyr Pro Gln Pro Gln Pro Gln Gln Ser Gln Gln Thr Ala 
            580                 585                 590         


Tyr Ser Gln Gln Arg Phe Pro Pro Pro Gln Glu Leu Ser Gln Asp Ser 
        595                 600                 605             


Phe Gly Ser Gln Ala Ser Ser Ala Pro Ser Met Thr Ser Ser Lys Gly 
    610                 615                 620                 


Gly Gln Glu Asp Met Asn Leu Ser Leu Gln Ser Arg Pro Ser Ser Leu 
625                 630                 635                 640 


Pro Asp Leu Ser Gly Ser Ile Asp Asp Leu Pro Met Gly Thr Glu Gly 
                645                 650                 655     


Ala Leu Ser Pro Gly Val Ser Thr Ser Gly Ile Ser Ser Ser Gln Gly 
            660                 665                 670         


Glu Gln Ser Asn Pro Ala Gln Ser Pro Phe Ser Pro His Thr Ser Pro 
        675                 680                 685             


His Leu Pro Gly Ile Arg Gly Pro Ser Pro Ser Pro Val Gly Ser Pro 
    690                 695                 700                 


Ala Ser Val Ala Gln Ser Arg Ser Gly Pro Leu Ser Pro Ala Ala Val 
705                 710                 715                 720 


Pro Gly Asn Gln Met Pro Pro Arg Pro Pro Ser Gly Gln Ser Asp Ser 
                725                 730                 735     


Ile Met His Pro Ser Met Asn Gln Ser Ser Ile Ala Gln Asp Arg Gly 
            740                 745                 750         


Tyr Met Gln Arg Asn Pro Gln Met Pro Gln Tyr Thr Ser Pro Gln Pro 
        755                 760                 765             


Gly Ser Ala Leu Ser Pro Arg Gln Pro Ser Gly Gly Gln Met His Ser 
    770                 775                 780                 


Gly Val Gly Ser Tyr Gln Gln Asn Ser Met Gly Ser Tyr Gly Pro Gln 
785                 790                 795                 800 


Gly Ser Gln Tyr Gly Pro Gln Gly Gly Tyr Pro Arg Gln Pro Asn Tyr 
                805                 810                 815     


Asn Ala Leu Pro Asn Ala Asn Tyr Pro Asn Ala Gly Met Ala Gly Ser 
            820                 825                 830         


Met Asn Pro Met Gly Ala Gly Gly Gln Met His Gly Gln Pro Gly Ile 
        835                 840                 845             


Pro Pro Tyr Gly Thr Leu Pro Pro Gly Arg Met Ala His Ala Ser Met 
    850                 855                 860                 


Gly Asn Arg Pro Tyr Gly Pro Asn Met Ala Asn Met Pro Pro Gln Val 
865                 870                 875                 880 


Gly Ser Gly Met Cys Pro Pro Pro Gly Gly Met Asn Arg Lys Thr Gln 
                885                 890                 895     


Glu Ser Ala Val Ala Met His Val Ala Ala Asn Ser Ile Gln Asn Arg 
            900                 905                 910         


Pro Pro Gly Tyr Pro Asn Met Asn Gln Gly Gly Met Met Gly Thr Gly 
        915                 920                 925             


Pro Pro Tyr Gly Gln Gly Ile Asn Ser Met Ala Gly Met Ile Asn Pro 
    930                 935                 940                 


Gln Gly Pro Pro Tyr Pro Met Gly Gly Thr Met Ala Asn Asn Ser Ala 
945                 950                 955                 960 


Gly Met Ala Ala Ser Pro Glu Met Met Gly Leu Gly Asp Val Lys Leu 
                965                 970                 975     


Thr Pro Ala Thr Lys Met Asn Asn Lys Ala Asp Gly Thr Pro Lys Thr 
            980                 985                 990         


Glu Ser Lys Ser Lys Lys Ser Ser  Ser Ser Thr Thr Thr  Asn Glu Lys 
        995                 1000                 1005             


Ile Thr  Lys Leu Tyr Glu Leu  Gly Gly Glu Pro Glu  Arg Lys Met 
    1010                 1015                 1020             


Trp Val  Asp Arg Tyr Leu Ala  Phe Thr Glu Glu Lys  Ala Met Gly 
    1025                 1030                 1035             


Met Thr  Asn Leu Pro Ala Val  Gly Arg Lys Pro Leu  Asp Leu Tyr 
    1040                 1045                 1050             


Arg Leu  Tyr Val Ser Val Lys  Glu Ile Gly Gly Leu  Thr Gln Val 
    1055                 1060                 1065             


Asn Lys  Asn Lys Lys Trp Arg  Glu Leu Ala Thr Asn  Leu Asn Val 
    1070                 1075                 1080             


Gly Thr  Ser Ser Ser Ala Ala  Ser Ser Leu Lys Lys  Gln Tyr Ile 
    1085                 1090                 1095             


Gln Cys  Leu Tyr Ala Phe Glu  Cys Lys Ile Glu Arg  Gly Glu Asp 
    1100                 1105                 1110             


Pro Pro  Pro Asp Ile Phe Ala  Ala Ala Asp Ser Lys  Lys Ser Gln 
    1115                 1120                 1125             


Pro Lys  Ile Gln Pro Pro Ser  Pro Ala Gly Ser Gly  Ser Met Gln 
    1130                 1135                 1140             


Gly Pro  Gln Thr Pro Gln Ser  Thr Ser Ser Ser Met  Ala Glu Gly 
    1145                 1150                 1155             


Gly Asp  Leu Lys Pro Pro Thr  Pro Ala Ser Thr Pro  His Ser Gln 
    1160                 1165                 1170             


Ile Pro  Pro Leu Pro Gly Met  Ser Arg Ser Asn Ser  Val Gly Ile 
    1175                 1180                 1185             


Gln Asp  Ala Phe Pro Asp Gly  Ser Asp Pro Thr Phe  Gln Lys Arg 
    1190                 1195                 1200             


Asn Ser  Met Thr Pro Asn Pro  Gly Tyr Gln Pro Ser  Met Asn Thr 
    1205                 1210                 1215             


Ser Asp  Met Met Gly Arg Met  Ser Tyr Glu Pro Asn  Lys Asp Pro 
    1220                 1225                 1230             


Tyr Gly  Ser Met Arg Lys Ala  Pro Gly Ser Asp Pro  Phe Met Ser 
    1235                 1240                 1245             


Ser Gly  Gln Gly Pro Asn Gly  Gly Met Gly Asp Pro  Tyr Ser Arg 
    1250                 1255                 1260             


Ala Ala  Gly Pro Gly Leu Gly  Ser Val Ala Met Gly  Pro Arg Gln 
    1265                 1270                 1275             


His Tyr  Pro Tyr Gly Gly Pro  Tyr Asp Arg Val Arg  Thr Glu Pro 
    1280                 1285                 1290             


Gly Ile  Gly Pro Glu Gly Asn  Met Gly Thr Gly Ala  Pro Gln Pro 
    1295                 1300                 1305             


Asn Leu  Met Pro Ser Thr Pro  Asp Ser Gly Met Tyr  Ser Pro Ser 
    1310                 1315                 1320             


Arg Tyr  Pro Pro Gln Gln Gln  Gln Gln Gln Gln Gln  Gln His Asp 
    1325                 1330                 1335             


Ser Tyr  Gly Asn Gln Phe Ser  Thr Gln Gly Thr Pro  Ser Ser Ser 
    1340                 1345                 1350             


Pro Phe  Pro Ser Gln Gln Thr  Thr Met Tyr Gln Gln  Gln Gln Gln 
    1355                 1360                 1365             


Asn Tyr  Lys Arg Pro Met Asp  Gly Thr Tyr Gly Pro  Pro Ala Lys 
    1370                 1375                 1380             


Arg His  Glu Gly Glu Met Tyr  Ser Val Pro Tyr Ser  Ala Gly Gln 
    1385                 1390                 1395             


Gly Gln  Pro Gln Gln Gln Gln  Leu Pro Ala Ala Gln  Ser Gln Pro 
    1400                 1405                 1410             


Ala Ser  Gln Pro Gln Ala Ala  Gln Pro Ser Pro Gln  Gln Asp Val 
    1415                 1420                 1425             


Tyr Asn  Gln Tyr Ser Asn Ala  Tyr Pro Ala Ser Ala  Thr Ala Ala 
    1430                 1435                 1440             


Thr Asp  Arg Arg Pro Ala Gly  Gly Pro Gln Asn Gln  Phe Pro Phe 
    1445                 1450                 1455             


Gln Phe  Gly Arg Asp Arg Val  Ser Ala Pro Pro Gly  Ser Ser Ala 
    1460                 1465                 1470             


Gln Gln  Asn Met Pro Pro Gln  Met Met Gly Gly Pro  Ile Gln Ala 
    1475                 1480                 1485             


Ser Ala  Glu Val Ala Gln Gln  Gly Thr Met Trp Gln  Gly Arg Asn 
    1490                 1495                 1500             


Asp Met  Thr Tyr Asn Tyr Ala  Asn Arg Gln Asn Thr  Gly Ser Ala 
    1505                 1510                 1515             


Thr Gln  Gly Pro Ala Tyr His  Gly Val Asn Arg Thr  Asp Glu Met 
    1520                 1525                 1530             


Leu His  Thr Asp Gln Arg Ala  Asn His Glu Gly Pro  Trp Pro Ser 
    1535                 1540                 1545             


His Gly  Thr Arg Gln Pro Pro  Tyr Gly Pro Ser Ala  Pro Val Pro 
    1550                 1555                 1560             


Pro Met  Thr Arg Pro Pro Pro  Ser Asn Tyr Gln Pro  Pro Pro Ser 
    1565                 1570                 1575             


Met Pro  Asn His Ile Pro Gln  Val Ser Ser Pro Ala  Pro Leu Pro 
    1580                 1585                 1590             


Arg Pro  Met Glu Asn Arg Thr  Ser Pro Ser Lys Ser  Pro Phe Leu 
    1595                 1600                 1605             


His Ser  Gly Met Lys Met Gln  Lys Ala Gly Pro Pro  Val Pro Ala 
    1610                 1615                 1620             


Ser His  Ile Ala Pro Thr Pro  Val Gln Pro Pro Met  Ile Arg Arg 
    1625                 1630                 1635             


Asp Ile  Thr Phe Pro Pro Gly  Ser Val Glu Ala Thr  Gln Pro Val 
    1640                 1645                 1650             


Leu Lys  Gln Arg Arg Arg Leu  Thr Met Lys Asp Ile  Gly Thr Pro 
    1655                 1660                 1665             


Glu Ala  Trp Arg Val Met Met  Ser Leu Lys Ser Gly  Leu Leu Ala 
    1670                 1675                 1680             


Glu Ser  Thr Trp Ala Leu Asp  Thr Ile Asn Ile Leu  Leu Tyr Asp 
    1685                 1690                 1695             


Asp Asn  Ser Ile Met Thr Phe  Asn Leu Ser Gln Leu  Pro Gly Leu 
    1700                 1705                 1710             


Leu Glu  Leu Leu Val Glu Tyr  Phe Arg Arg Cys Leu  Ile Glu Ile 
    1715                 1720                 1725             


Phe Gly  Ile Leu Lys Glu Tyr  Glu Val Gly Asp Pro  Gly Gln Arg 
    1730                 1735                 1740             


Thr Leu  Leu Asp Pro Gly Arg  Phe Thr Lys Val Tyr  Ser Pro Ala 
    1745                 1750                 1755             


His Thr  Glu Glu Glu Glu Glu  Glu His Leu Asp Pro  Lys Leu Glu 
    1760                 1765                 1770             


Glu Glu  Glu Glu Glu Gly Val  Gly Asn Asp Glu Glu  Met Ala Phe 
    1775                 1780                 1785             


Leu Gly  Lys Asp Lys Pro Ser  Ser Glu Asn Asn Glu  Glu Lys Leu 
    1790                 1795                 1800             


Val Ser  Lys Phe Asp Lys Leu  Pro Val Lys Ile Val  Gln Arg Asn 
    1805                 1810                 1815             


Asp Pro  Phe Val Val Asp Cys  Ser Asp Lys Leu Gly  Arg Val Gln 
    1820                 1825                 1830             


Glu Phe  Asp Ser Gly Leu Leu  His Trp Arg Ile Gly  Gly Gly Asp 
    1835                 1840                 1845             


Thr Thr  Glu His Ile Gln Thr  His Phe Glu Ser Lys  Ile Glu Leu 
    1850                 1855                 1860             


Leu Pro  Ser Arg Pro Tyr Val  Pro Cys Pro Thr Pro  Pro Arg Lys 
    1865                 1870                 1875             


His Leu  Thr Thr Val Glu Gly  Thr Pro Gly Thr Thr  Glu Gln Glu 
    1880                 1885                 1890             


Gly Pro  Pro Pro Asp Gly Leu  Pro Glu Lys Arg Ile  Thr Ala Thr 
    1895                 1900                 1905             


Met Asp  Asp Met Leu Ser Thr  Arg Ser Ser Thr Leu  Thr Asp Glu 
    1910                 1915                 1920             


Gly Ala  Lys Ser Ala Glu Ala  Thr Lys Glu Ser Ser  Lys Phe Pro 
    1925                 1930                 1935             


Phe Gly  Ile Ser Pro Ala Gln  Ser His Arg Asn Ile  Lys Ile Leu 
    1940                 1945                 1950             


Glu Asp  Glu Pro His Ser Lys  Asp Glu Thr Pro Leu  Cys Thr Leu 
    1955                 1960                 1965             


Leu Asp  Trp Gln Asp Ser Leu  Ala Lys Arg Cys Val  Cys Val Ser 
    1970                 1975                 1980             


Asn Thr  Ile Arg Ser Leu Ser  Phe Val Pro Gly Asn  Asp Phe Glu 
    1985                 1990                 1995             


Met Ser  Lys His Pro Gly Leu  Leu Leu Ile Leu Gly  Lys Leu Ile 
    2000                 2005                 2010             


Leu Leu  His His Lys His Pro  Glu Arg Lys Gln Ala  Pro Leu Thr 
    2015                 2020                 2025             


Tyr Glu  Lys Glu Glu Glu Gln  Asp Gln Gly Val Ser  Cys Asp Lys 
    2030                 2035                 2040             


Val Glu  Trp Trp Trp Asp Cys  Leu Glu Met Leu Arg  Glu Asn Thr 
    2045                 2050                 2055             


Leu Val  Thr Leu Ala Asn Ile  Ser Gly Gln Leu Asp  Leu Ser Pro 
    2060                 2065                 2070             


Tyr Pro  Glu Ser Ile Cys Leu  Pro Val Leu Asp Gly  Leu Leu His 
    2075                 2080                 2085             


Trp Ala  Val Cys Pro Ser Ala  Glu Ala Gln Asp Pro  Phe Ser Thr 
    2090                 2095                 2100             


Leu Gly  Pro Asn Ala Val Leu  Ser Pro Gln Arg Leu  Val Leu Glu 
    2105                 2110                 2115             


Thr Leu  Ser Lys Leu Ser Ile  Gln Asp Asn Asn Val  Asp Leu Ile 
    2120                 2125                 2130             


Leu Ala  Thr Pro Pro Phe Ser  Arg Leu Glu Lys Leu  Tyr Ser Thr 
    2135                 2140                 2145             


Met Val  Arg Phe Leu Ser Asp  Arg Lys Asn Pro Val  Cys Arg Glu 
    2150                 2155                 2160             


Met Ala  Val Val Leu Leu Ala  Asn Leu Ala Gln Gly  Asp Ser Leu 
    2165                 2170                 2175             


Ala Ala  Arg Ala Ile Ala Val  Gln Lys Gly Ser Ile  Gly Asn Leu 
    2180                 2185                 2190             


Leu Gly  Phe Leu Glu Asp Ser  Leu Ala Ala Thr Gln  Phe Gln Gln 
    2195                 2200                 2205             


Ser Gln  Ala Ser Leu Leu His  Met Gln Asn Pro Pro  Phe Glu Pro 
    2210                 2215                 2220             


Thr Ser  Val Asp Met Met Arg  Arg Ala Ala Arg Ala  Leu Leu Ala 
    2225                 2230                 2235             


Leu Ala  Lys Val Asp Glu Asn  His Ser Glu Phe Thr  Leu Tyr Glu 
    2240                 2245                 2250             


Ser Arg  Leu Leu Asp Ile Ser  Val Ser Pro Leu Met  Asn Ser Leu 
    2255                 2260                 2265             


Val Ser  Gln Val Ile Cys Asp  Val Leu Phe Leu Ile  Gly Gln Ser 
    2270                 2275                 2280             


<210> 52
<211> 9609
<212> DNA
<213> Homo sapiens

<400> 52
atggcccata acgcgggcgc cgcggccgcc gccggcaccc acagcgccaa gagcggcggc       60

tccgaggcgg ctctcaagga gggtggaagc gccgccgcgc tgtcctcctc ctcctcctcc      120

tccgcggcgg cagcggcggc atcctcttcc tcctcgtcgg gcccgggctc ggccatggag      180

acggggctgc tccccaacca caaactgaaa accgttggcg aagcccccgc cgcgccgccc      240

caccagcagc accaccacca ccaccatgcc caccaccacc accaccatgc ccaccacctc      300

caccaccacc acgcactaca gcagcagcta aaccagttcc agcagcagca gcagcagcag      360

caacagcagc agcagcagca gcagcaacag caacatccca tttccaacaa caacagcttg      420

ggcggcgcgg gcggcggcgc gcctcagccc ggccccgaca tggagcagcc gcaacatgga      480

ggcgccaagg acagtgctgc gggcggccag gccgaccccc cgggcccgcc gctgctgagc      540

aagccgggcg acgaggacga cgcgccgccc aagatggggg agccggcggg cggccgctac      600

gagcacccgg gcttgggcgc cctgggcacg cagcagccgc cggtcgccgt gcccgggggc      660

ggcggcggcc cggcggccgt cccggagttt aataattact atggcagcgc tgcccctgcg      720

agcggcggcc ccggcggccg cgctgggcct tgctttgatc aacatggcgg acaacaaagc      780

cccgggatgg ggatgatgca ctccgcctcc gccgccgccg ccggggcccc cggcagcatg      840

gaccccctgc agaactccca cgaagggtac cccaacagcc agtgcaacca ttatccgggc      900

tacagccggc ccggcgcggg cggcggcggc ggcggcggcg gcggaggagg aggaggcagc      960

ggaggaggag gaggaggagg aggagcagga gcaggaggag caggagcggg agctgtggcg     1020

gcggcggccg cggcggcggc ggcagcagca ggaggcggcg gcggcggcgg ctatgggggc     1080

tcgtccgcgg ggtacggggt gctgagctcc ccccggcagc agggcggcgg catgatgatg     1140

ggccccgggg gcggcggggc cgcgagcctc agcaaggcgg ccgccggctc ggcggcgggg     1200

ggcttccagc gcttcgccgg ccagaaccag cacccgtcgg gggccacccc gaccctcaat     1260

cagctgctca cctcgcccag ccccatgatg cggagctacg gcggcagcta ccccgagtac     1320

agcagcccca gcgcgccgcc gccgccgccg tcgcagcccc agtcccaggc ggcggcggcg     1380

ggggcggcgg cgggcggcca gcaggcggcc gcgggcatgg gcttgggcaa ggacatgggc     1440

gcccagtacg ccgctgccag cccggcctgg gcggccgcgc aacaaaggag tcacccggcg     1500

atgagccccg gcacccccgg accgaccatg ggcagatccc agggcagccc aatggatcca     1560

atggtgatga agagacctca gttgtatggc atgggcagta accctcattc tcagcctcag     1620

cagagcagtc cgtacccagg aggttcctat ggccctccag gcccacagcg gtatccaatt     1680

ggcatccagg gtcggactcc cggggccatg gccggaatgc agtaccctca gcagcagatg     1740

ccacctcagt atggacagca aggtgtgagt ggttactgcc agcagggcca acagccatat     1800

tacagccagc agccgcagcc cccgcacctc ccaccccagg cgcagtatct gccgtcccag     1860

tcccagcaga ggtaccagcc gcagcaggac atgtctcagg aaggctatgg aactagatct     1920

caacctcctc tggcccccgg aaaacctaac catgaagact tgaacttaat acagcaagaa     1980

agaccatcaa gtttaccaga tctgtctggc tccattgatg acctccccac gggaacggaa     2040

gcaactttga gctcagcagt cagtgcatcc gggtccacga gcagccaagg ggatcagagc     2100

aacccggcgc agtcgccttt ctccccacat gcgtcccctc atctctccag catcccgggg     2160

ggcccatctc cctctcctgt tggctctcct gtaggaagca accagtctcg atctggccca     2220

atctctcctg caagtatccc aggtagtcag atgcctccgc agccacccgg gagccagtca     2280

gaatccagtt cccatcccgc cttgagccag tcaccaatgc cacaggaaag aggttttatg     2340

gcaggcacac aaagaaaccc tcagatggct cagtatggac ctcaacagac aggaccatcc     2400

atgtcgcctc atccttctcc tgggggccag atgcatgctg gaatcagtag ctttcagcag     2460

agtaactcaa gtgggactta cggtccacag atgagccagt atggaccaca aggtaactac     2520

tccagacccc cagcgtatag tggggtgccc agtgcaagct acagcggccc agggcccggt     2580

atgggtatca gtgccaacaa ccagatgcat ggacaagggc caagccagcc atgtggtgct     2640

gtgcccctgg gacgaatgcc atcagctggg atgcagaaca gaccatttcc tggaaatatg     2700

agcagcatga cccccagttc tcctggcatg tctcagcagg gagggccagg aatggggccg     2760

ccaatgccaa ctgtgaaccg taaggcacag gaggcagccg cagcagtgat gcaggctgct     2820

gcgaactcag cacaaagcag gcaaggcagt ttccccggca tgaaccagag tggacttatg     2880

gcttccagct ctccctacag ccagcccatg aacaacagct ctagcctgat gaacacgcag     2940

gcgccgccct acagcatggc gcccgccatg gtgaacagct cggcagcatc tgtgggtctt     3000

gcagatatga tgtctcctgg tgaatccaaa ctgcccctgc ctctcaaagc agacggcaaa     3060

gaagaaggca ctccacagcc cgagagcaag tcaaagaagt ccagctcctc caccactact     3120

ggggagaaga tcacgaaggt gtacgagctg gggaatgagc cagagagaaa gctctgggtc     3180

gaccgatacc tcaccttcat ggaagagaga ggctctcctg tctcaagtct gcctgccgtg     3240

ggcaagaagc ccctggacct gttccgactc tacgtctgcg tcaaagagat cgggggtttg     3300

gcccaggtta ataaaaacaa gaagtggcgt gagctggcaa ccaacctaaa cgttggcacc     3360

tcaagcagtg cagcgagctc cctgaaaaag cagtatattc agtacctgtt tgcctttgag     3420

tgcaagatcg aacgtgggga ggagcccccg ccggaagtct tcagcaccgg ggacaccaaa     3480

aagcagccca agctccagcc gccatctcct gctaactcgg gatccttgca aggcccacag     3540

accccccagt caactggcag caattccatg gcagaggttc caggtgacct gaagccacct     3600

accccagcct ccacccctca cggccagatg actccaatgc aaggtggaag aagcagtaca     3660

atcagtgtgc acgacccatt ctcagatgtg agtgattcat ccttcccgaa acggaactcc     3720

atgactccaa acgcccccta ccagcagggc atgagcatgc ccgatgtgat gggcaggatg     3780

ccctatgagc ccaacaagga cccctttggg ggaatgagaa aagtgcctgg aagcagcgag     3840

ccctttatga cgcaaggaca gatgcccaac agcagcatgc aggacatgta caaccaaagt     3900

ccctccggag caatgtctaa cctgggcatg gggcagcgcc agcagtttcc ctatggagcc     3960

agttacgacc gaaggcatga accttatggg cagcagtatc caggccaagg ccctccctcg     4020

ggacagccgc cgtatggagg gcaccagccc ggcctgtacc cacagcagcc gaattacaaa     4080

cgccatatgg acggcatgta cgggccccca gccaagcgcc acgagggcga catgtacaac     4140

atgcagtaca gcagccagca gcaggagatg tacaaccagt atggaggctc ctactcgggc     4200

ccggaccgca ggcccatcca gggccagtac ccgtatccct acagcaggga gaggatgcag     4260

ggcccggggc agatccagac acacggaatc ccgcctcaga tgatgggcgg cccgctgcag     4320

tcgtcctcca gtgaggggcc tcagcagaat atgtgggcag cacgcaatga tatgccttat     4380

ccctaccaga acaggcaggg ccctggcggc cctacacagg cgccccctta cccaggcatg     4440

aaccgcacag acgatatgat ggtacccgat cagaggataa atcatgagag ccagtggcct     4500

tctcacgtca gccagcgtca gccttatatg tcgtcctcag cctccatgca gcccatcaca     4560

cgcccaccac agccgtccta ccagacgcca ccgtcactgc caaatcacat ctccagggcg     4620

cccagcccag cgtccttcca gcgctccctg gagaaccgca tgtctccaag caagtctcct     4680

tttctgccgt ctatgaagat gcagaaggtc atgcccacgg tccccacatc ccaggtcacc     4740

gggccaccac cccaaccacc cccaatcaga agggagatca cctttcctcc tggctcagta     4800

gaagcatcac aaccagtctt gaaacaaagg cgaaagatta cctccaaaga tatcgttact     4860

cctgaggcgt ggcgtgtgat gatgtccctt aaatcaggtc ttttggctga gagtacgtgg     4920

gctttggaca ctattaatat tcttctgtat gatgacagca ctgttgctac tttcaatctc     4980

tcccagttgt ctggatttct cgaactttta gtcgagtact ttagaaaatg cctgattgac     5040

atttttggaa ttcttatgga atatgaagtg ggagacccca gccaaaaagc acttgatcac     5100

aacgcagcaa ggaaggatga cagccagtcc ttggcagacg attctgggaa agaggaggaa     5160

gatgctgaat gtattgatga cgacgaggaa gacgaggagg atgaggagga agacagcgag     5220

aagacagaaa gcgatgaaaa gagcagcatc gctctgactg ccccggacgc cgctgcagac     5280

ccaaaggaga agcccaagca agccagtaag ttcgacaagc tgccaataaa gatagtcaaa     5340

aagaacaacc tgtttgttgt tgaccgatct gacaagttgg ggcgtgtgca ggagttcaat     5400

agtggccttc tgcactggca gctcggcggg ggtgacacca ccgagcacat tcagactcac     5460

tttgagagca agatggaaat tcctcctcgc aggcgcccac ctcccccctt aagctccgca     5520

ggtagaaaga aagagcaaga aggcaaaggc gactctgaag agcagcaaga gaaaagcatc     5580

atagcaacca tcgatgacgt cctctctgct cggccagggg cattgcctga agacgcaaac     5640

cctgggcccc agaccgaaag cagtaagttt ccctttggta tccagcaagc caaaagtcac     5700

cggaacatca agctgctgga ggacgagccc aggagccgag acgagactcc tctgtgtacc     5760

atcgcgcact ggcaggactc gctggctaag cgatgcatct gtgtgtccaa tattgtccgt     5820

agcttgtcat tcgtgcctgg caatgatgcc gaaatgtcca aacatccagg cctggtgctg     5880

atcctgggga agctgattct tcttcaccac gagcatccag agagaaagcg agcaccgcag     5940

acctatgaga aagaggagga tgaggacaag ggggtggcct gcagcaaaga tgagtggtgg     6000

tgggactgcc tcgaggtctt gagggataac acgttggtca cgttggccaa catttccggg     6060

cagctagact tgtctgctta cacggaaagc atctgcttgc caattttgga tggcttgctg     6120

cactggatgg tgtgcccgtc tgcagaggca caagatccct ttccaactgt gggacccaac     6180

tcggtcctgt cgcctcagag acttgtgctg gagaccctct gtaaactcag tatccaggac     6240

aataatgtgg acctgatctt ggccactcct ccatttagtc gtcaggagaa attctatgct     6300

acattagtta ggtacgttgg ggatcgcaaa aacccagtct gtcgagaaat gtccatggcg     6360

cttttatcga accttgccca aggggacgca ctagcagcaa gggccatagc tgtgcagaaa     6420

ggaagcattg gaaacttgat aagcttccta gaggatgggg tcacgatggc ccagtaccag     6480

cagagccagc acaacctcat gcacatgcag cccccgcccc tggaaccacc tagcgtagac     6540

atgatgtgca gggcggccaa ggctttgcta gccatggcca gagtggacga aaaccgctcg     6600

gaattccttt tgcacgaggg ccggttgctg gatatctcga tatcagctgt cctgaactct     6660

ctggttgcat ctgtcatctg tgatgtactg tttcagattg ggcagttatg acataagtga     6720

gaaggcaagc atgtgtgagt gaagattaga gggtcacata taactggctg ttttctgttc     6780

ttgtttatcc agcgtaggaa gaaggaaaag aaaatctttg ctcctctgcc ccattcacta     6840

tttaccaatt gggaattaaa gaaataatta atttgaacag ttatgaaatt aatatttgct     6900

gtctgtgtgt ataagtacat cctttggggt tttttttttc tctttttttt aaccaaagtt     6960

gctgtctagt gcattcaaag gtcacttttt gttcttcaca gatcttttta atgttctttc     7020

ccatgttgta ttgcattttt gggggaagca aattgacttt aaagaaaaaa gttgtggcaa     7080

aagatgctaa gatgcgaaaa tttcaccaca ctgagtcaaa aaggtgaaaa attatccatt     7140

tcctatgcgt tttactcctc agagaatgaa aaaaactgca tcccatcacc caaagttctg     7200

tgcaatagaa atttctacag atacaggtat aggggctcaa ggaggtatgt cggtcagtag     7260

tcaaaactat gaaatgatac tggtttctcc acaggaatat ggttccatta ggctgggagc     7320

aaaaacaatg ttttttaaga ttgagaatac atacctgaca acgatccgga aactgctcct     7380

caccactccc gtcatgcctg ctgtcggcgt ttgaccttcc acgtgacagt tcttcacaat     7440

tcctttcatc attttttaaa tatttttttt actgcctatg ggctgtgatg tatatagaag     7500

ttgtacatta aacataccct catttttttc ttttcttttt tttttttttt tttagtacaa     7560

agttttagtt tctttttcat gatgtggtaa ctacgaagtg atggtagatt taaataattt     7620

tttattttta ttttatatat tttttcatta gggccatatc tccaaaaaaa gaaagaaaaa     7680

atacaaaaaa caaaaacaaa aaaaaaagag ggtaatgtac aagtttctgt atgtataaag     7740

tcatgctcga tttcaggaga gcagctgatc acaatttgct tcatgaatca aggtgtggaa     7800

atggttatat atggattgat ttagaaaatg gttaccagta cagtcaaaaa agagaaaatg     7860

aaaaaaatac aactaaaagg aagaaacaca acttcaaaga tttttcagtg atgagaatcc     7920

acatttgtat ttcaagataa tgtagtttaa aaaaaaaaaa aagaaaaaaa cttgatgtaa     7980

attcctcctt ttcctctggc ttaatgaata tcatttattc agtataaaat ctttatatgt     8040

tccacatgtt aagaataaat gtacattaaa tcttgttaag cactgtgatg ggtgttcttg     8100

aatactgttc tagtttcctt aaagtggttt cctagtaatc aagttattta caagaaatag     8160

gggaatgcag cagtgtattc acattataaa accctacatt tggaagagac ctttaggggt     8220

tacctacttt agagtgggga gcaacagttt gattttctca aattacttag ctaattagtc     8280

tttctttgaa gcaattaact ctaacgacat tgaggtatga tcattttcag tatttatggg     8340

aggtggctgc tgacccactt gaggtgagat ctcagaagct taactggcct gaaaatgtaa     8400

cattctgcct tttactaact ccatcttagt ttaatcaaag ttcaatctat tccttgtttc     8460

ttctgtgtgc ctcagagtta ttttgcattt agtttactcc accgtgtata atatttatac     8520

tgtgcaatgt taaaaaagaa tctgttatat tgtatgtggt gtacatagtg caaagtgatg     8580

atttctattt cagggcatat tatggttctc atattccttc ctacctggtg cacagtagct     8640

ttttaatact agtcacttct aatttaaact ttctcttcct gggtcattga ctgttactgt     8700

gtaataatcg atttctttga aactgctgca taattatgct gttagtggac ctctacctct     8760

tctcttccct ctcccaatca cagtatactc agaatcccca gcccctcgca tacattgtgt     8820

cggttcacat tactcacagt aatatatgga agagttagac aagaacatgc agttacagtc     8880

attgtgagac gtgactctcc agtgtcacga ggaaaaaaat catcttttct gcaaacagtc     8940

tctcatctgt caactcccac attactgagt caaacagtct tcttacataa caatgcaacc     9000

aaatatatgt tgaattaaag acccatttat aattctgctt taaatacatc tgcttgctaa     9060

gaacagattt cagtgctcca agcttcaaat atggagattt gtaagaggga attcaatatt     9120

attctaattt ctctcttaca gagtacaaat aaaaggtgta tacaaactcc gaacatatcc     9180

agtattccaa ttcctttgtc aatcagaaga gtaaaataat taacaaaaga ctgttgttat     9240

ggtttgcatt gtaaccgata cgcagagtct gaccgttggg caacaagttt ttctatcctg     9300

atgcgcaaca cagtctctag agactaatcc aggaagactt tagcctcctt tccatattct     9360

cacccccgaa tcaagattta cagaagccca cgaagaattt acagcctgct tgagatcatc     9420

ttgcctataa actgagttat tgctttgtcc taaaaattag tcggtttttt tttttctatg     9480

aggcttttca gaaatttaca ggatgcccag actttacatg tgtaccaaaa aaaaaaaaaa     9540

gataaaaaat aaaggtgcaa agaaagttta gtattttgga atggtgctat aaagttgaaa     9600

aaaaaaaaa                                                             9609


<210> 53
<211> 2236
<212> PRT
<213> Homo sapiens

<400> 53
Met Ala His Asn Ala Gly Ala Ala Ala Ala Ala Gly Thr His Ser Ala 
1               5                   10                  15      


Lys Ser Gly Gly Ser Glu Ala Ala Leu Lys Glu Gly Gly Ser Ala Ala 
            20                  25                  30          


Ala Leu Ser Ser Ser Ser Ser Ser Ser Ala Ala Ala Ala Ala Ala Ser 
        35                  40                  45              


Ser Ser Ser Ser Ser Gly Pro Gly Ser Ala Met Glu Thr Gly Leu Leu 
    50                  55                  60                  


Pro Asn His Lys Leu Lys Thr Val Gly Glu Ala Pro Ala Ala Pro Pro 
65                  70                  75                  80  


His Gln Gln His His His His His His Ala His His His His His His 
                85                  90                  95      


Ala His His Leu His His His His Ala Leu Gln Gln Gln Leu Asn Gln 
            100                 105                 110         


Phe Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
        115                 120                 125             


Gln Gln Gln His Pro Ile Ser Asn Asn Asn Ser Leu Gly Gly Ala Gly 
    130                 135                 140                 


Gly Gly Ala Pro Gln Pro Gly Pro Asp Met Glu Gln Pro Gln His Gly 
145                 150                 155                 160 


Gly Ala Lys Asp Ser Ala Ala Gly Gly Gln Ala Asp Pro Pro Gly Pro 
                165                 170                 175     


Pro Leu Leu Ser Lys Pro Gly Asp Glu Asp Asp Ala Pro Pro Lys Met 
            180                 185                 190         


Gly Glu Pro Ala Gly Gly Arg Tyr Glu His Pro Gly Leu Gly Ala Leu 
        195                 200                 205             


Gly Thr Gln Gln Pro Pro Val Ala Val Pro Gly Gly Gly Gly Gly Pro 
    210                 215                 220                 


Ala Ala Val Pro Glu Phe Asn Asn Tyr Tyr Gly Ser Ala Ala Pro Ala 
225                 230                 235                 240 


Ser Gly Gly Pro Gly Gly Arg Ala Gly Pro Cys Phe Asp Gln His Gly 
                245                 250                 255     


Gly Gln Gln Ser Pro Gly Met Gly Met Met His Ser Ala Ser Ala Ala 
            260                 265                 270         


Ala Ala Gly Ala Pro Gly Ser Met Asp Pro Leu Gln Asn Ser His Glu 
        275                 280                 285             


Gly Tyr Pro Asn Ser Gln Cys Asn His Tyr Pro Gly Tyr Ser Arg Pro 
    290                 295                 300                 


Gly Ala Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Ser 
305                 310                 315                 320 


Gly Gly Gly Gly Gly Gly Gly Gly Ala Gly Ala Gly Gly Ala Gly Ala 
                325                 330                 335     


Gly Ala Val Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Gly Gly 
            340                 345                 350         


Gly Gly Gly Gly Gly Tyr Gly Gly Ser Ser Ala Gly Tyr Gly Val Leu 
        355                 360                 365             


Ser Ser Pro Arg Gln Gln Gly Gly Gly Met Met Met Gly Pro Gly Gly 
    370                 375                 380                 


Gly Gly Ala Ala Ser Leu Ser Lys Ala Ala Ala Gly Ser Ala Ala Gly 
385                 390                 395                 400 


Gly Phe Gln Arg Phe Ala Gly Gln Asn Gln His Pro Ser Gly Ala Thr 
                405                 410                 415     


Pro Thr Leu Asn Gln Leu Leu Thr Ser Pro Ser Pro Met Met Arg Ser 
            420                 425                 430         


Tyr Gly Gly Ser Tyr Pro Glu Tyr Ser Ser Pro Ser Ala Pro Pro Pro 
        435                 440                 445             


Pro Pro Ser Gln Pro Gln Ser Gln Ala Ala Ala Ala Gly Ala Ala Ala 
    450                 455                 460                 


Gly Gly Gln Gln Ala Ala Ala Gly Met Gly Leu Gly Lys Asp Met Gly 
465                 470                 475                 480 


Ala Gln Tyr Ala Ala Ala Ser Pro Ala Trp Ala Ala Ala Gln Gln Arg 
                485                 490                 495     


Ser His Pro Ala Met Ser Pro Gly Thr Pro Gly Pro Thr Met Gly Arg 
            500                 505                 510         


Ser Gln Gly Ser Pro Met Asp Pro Met Val Met Lys Arg Pro Gln Leu 
        515                 520                 525             


Tyr Gly Met Gly Ser Asn Pro His Ser Gln Pro Gln Gln Ser Ser Pro 
    530                 535                 540                 


Tyr Pro Gly Gly Ser Tyr Gly Pro Pro Gly Pro Gln Arg Tyr Pro Ile 
545                 550                 555                 560 


Gly Ile Gln Gly Arg Thr Pro Gly Ala Met Ala Gly Met Gln Tyr Pro 
                565                 570                 575     


Gln Gln Gln Met Pro Pro Gln Tyr Gly Gln Gln Gly Val Ser Gly Tyr 
            580                 585                 590         


Cys Gln Gln Gly Gln Gln Pro Tyr Tyr Ser Gln Gln Pro Gln Pro Pro 
        595                 600                 605             


His Leu Pro Pro Gln Ala Gln Tyr Leu Pro Ser Gln Ser Gln Gln Arg 
    610                 615                 620                 


Tyr Gln Pro Gln Gln Asp Met Ser Gln Glu Gly Tyr Gly Thr Arg Ser 
625                 630                 635                 640 


Gln Pro Pro Leu Ala Pro Gly Lys Pro Asn His Glu Asp Leu Asn Leu 
                645                 650                 655     


Ile Gln Gln Glu Arg Pro Ser Ser Leu Pro Asp Leu Ser Gly Ser Ile 
            660                 665                 670         


Asp Asp Leu Pro Thr Gly Thr Glu Ala Thr Leu Ser Ser Ala Val Ser 
        675                 680                 685             


Ala Ser Gly Ser Thr Ser Ser Gln Gly Asp Gln Ser Asn Pro Ala Gln 
    690                 695                 700                 


Ser Pro Phe Ser Pro His Ala Ser Pro His Leu Ser Ser Ile Pro Gly 
705                 710                 715                 720 


Gly Pro Ser Pro Ser Pro Val Gly Ser Pro Val Gly Ser Asn Gln Ser 
                725                 730                 735     


Arg Ser Gly Pro Ile Ser Pro Ala Ser Ile Pro Gly Ser Gln Met Pro 
            740                 745                 750         


Pro Gln Pro Pro Gly Ser Gln Ser Glu Ser Ser Ser His Pro Ala Leu 
        755                 760                 765             


Ser Gln Ser Pro Met Pro Gln Glu Arg Gly Phe Met Ala Gly Thr Gln 
    770                 775                 780                 


Arg Asn Pro Gln Met Ala Gln Tyr Gly Pro Gln Gln Thr Gly Pro Ser 
785                 790                 795                 800 


Met Ser Pro His Pro Ser Pro Gly Gly Gln Met His Ala Gly Ile Ser 
                805                 810                 815     


Ser Phe Gln Gln Ser Asn Ser Ser Gly Thr Tyr Gly Pro Gln Met Ser 
            820                 825                 830         


Gln Tyr Gly Pro Gln Gly Asn Tyr Ser Arg Pro Pro Ala Tyr Ser Gly 
        835                 840                 845             


Val Pro Ser Ala Ser Tyr Ser Gly Pro Gly Pro Gly Met Gly Ile Ser 
    850                 855                 860                 


Ala Asn Asn Gln Met His Gly Gln Gly Pro Ser Gln Pro Cys Gly Ala 
865                 870                 875                 880 


Val Pro Leu Gly Arg Met Pro Ser Ala Gly Met Gln Asn Arg Pro Phe 
                885                 890                 895     


Pro Gly Asn Met Ser Ser Met Thr Pro Ser Ser Pro Gly Met Ser Gln 
            900                 905                 910         


Gln Gly Gly Pro Gly Met Gly Pro Pro Met Pro Thr Val Asn Arg Lys 
        915                 920                 925             


Ala Gln Glu Ala Ala Ala Ala Val Met Gln Ala Ala Ala Asn Ser Ala 
    930                 935                 940                 


Gln Ser Arg Gln Gly Ser Phe Pro Gly Met Asn Gln Ser Gly Leu Met 
945                 950                 955                 960 


Ala Ser Ser Ser Pro Tyr Ser Gln Pro Met Asn Asn Ser Ser Ser Leu 
                965                 970                 975     


Met Asn Thr Gln Ala Pro Pro Tyr Ser Met Ala Pro Ala Met Val Asn 
            980                 985                 990         


Ser Ser Ala Ala Ser Val Gly Leu  Ala Asp Met Met Ser  Pro Gly Glu 
        995                 1000                 1005             


Ser Lys  Leu Pro Leu Pro Leu  Lys Ala Asp Gly Lys  Glu Glu Gly 
    1010                 1015                 1020             


Thr Pro  Gln Pro Glu Ser Lys  Ser Lys Lys Ser Ser  Ser Ser Thr 
    1025                 1030                 1035             


Thr Thr  Gly Glu Lys Ile Thr  Lys Val Tyr Glu Leu  Gly Asn Glu 
    1040                 1045                 1050             


Pro Glu  Arg Lys Leu Trp Val  Asp Arg Tyr Leu Thr  Phe Met Glu 
    1055                 1060                 1065             


Glu Arg  Gly Ser Pro Val Ser  Ser Leu Pro Ala Val  Gly Lys Lys 
    1070                 1075                 1080             


Pro Leu  Asp Leu Phe Arg Leu  Tyr Val Cys Val Lys  Glu Ile Gly 
    1085                 1090                 1095             


Gly Leu  Ala Gln Val Asn Lys  Asn Lys Lys Trp Arg  Glu Leu Ala 
    1100                 1105                 1110             


Thr Asn  Leu Asn Val Gly Thr  Ser Ser Ser Ala Ala  Ser Ser Leu 
    1115                 1120                 1125             


Lys Lys  Gln Tyr Ile Gln Tyr  Leu Phe Ala Phe Glu  Cys Lys Ile 
    1130                 1135                 1140             


Glu Arg  Gly Glu Glu Pro Pro  Pro Glu Val Phe Ser  Thr Gly Asp 
    1145                 1150                 1155             


Thr Lys  Lys Gln Pro Lys Leu  Gln Pro Pro Ser Pro  Ala Asn Ser 
    1160                 1165                 1170             


Gly Ser  Leu Gln Gly Pro Gln  Thr Pro Gln Ser Thr  Gly Ser Asn 
    1175                 1180                 1185             


Ser Met  Ala Glu Val Pro Gly  Asp Leu Lys Pro Pro  Thr Pro Ala 
    1190                 1195                 1200             


Ser Thr  Pro His Gly Gln Met  Thr Pro Met Gln Gly  Gly Arg Ser 
    1205                 1210                 1215             


Ser Thr  Ile Ser Val His Asp  Pro Phe Ser Asp Val  Ser Asp Ser 
    1220                 1225                 1230             


Ser Phe  Pro Lys Arg Asn Ser  Met Thr Pro Asn Ala  Pro Tyr Gln 
    1235                 1240                 1245             


Gln Gly  Met Ser Met Pro Asp  Val Met Gly Arg Met  Pro Tyr Glu 
    1250                 1255                 1260             


Pro Asn  Lys Asp Pro Phe Gly  Gly Met Arg Lys Val  Pro Gly Ser 
    1265                 1270                 1275             


Ser Glu  Pro Phe Met Thr Gln  Gly Gln Met Pro Asn  Ser Ser Met 
    1280                 1285                 1290             


Gln Asp  Met Tyr Asn Gln Ser  Pro Ser Gly Ala Met  Ser Asn Leu 
    1295                 1300                 1305             


Gly Met  Gly Gln Arg Gln Gln  Phe Pro Tyr Gly Ala  Ser Tyr Asp 
    1310                 1315                 1320             


Arg Arg  His Glu Pro Tyr Gly  Gln Gln Tyr Pro Gly  Gln Gly Pro 
    1325                 1330                 1335             


Pro Ser  Gly Gln Pro Pro Tyr  Gly Gly His Gln Pro  Gly Leu Tyr 
    1340                 1345                 1350             


Pro Gln  Gln Pro Asn Tyr Lys  Arg His Met Asp Gly  Met Tyr Gly 
    1355                 1360                 1365             


Pro Pro  Ala Lys Arg His Glu  Gly Asp Met Tyr Asn  Met Gln Tyr 
    1370                 1375                 1380             


Ser Ser  Gln Gln Gln Glu Met  Tyr Asn Gln Tyr Gly  Gly Ser Tyr 
    1385                 1390                 1395             


Ser Gly  Pro Asp Arg Arg Pro  Ile Gln Gly Gln Tyr  Pro Tyr Pro 
    1400                 1405                 1410             


Tyr Ser  Arg Glu Arg Met Gln  Gly Pro Gly Gln Ile  Gln Thr His 
    1415                 1420                 1425             


Gly Ile  Pro Pro Gln Met Met  Gly Gly Pro Leu Gln  Ser Ser Ser 
    1430                 1435                 1440             


Ser Glu  Gly Pro Gln Gln Asn  Met Trp Ala Ala Arg  Asn Asp Met 
    1445                 1450                 1455             


Pro Tyr  Pro Tyr Gln Asn Arg  Gln Gly Pro Gly Gly  Pro Thr Gln 
    1460                 1465                 1470             


Ala Pro  Pro Tyr Pro Gly Met  Asn Arg Thr Asp Asp  Met Met Val 
    1475                 1480                 1485             


Pro Asp  Gln Arg Ile Asn His  Glu Ser Gln Trp Pro  Ser His Val 
    1490                 1495                 1500             


Ser Gln  Arg Gln Pro Tyr Met  Ser Ser Ser Ala Ser  Met Gln Pro 
    1505                 1510                 1515             


Ile Thr  Arg Pro Pro Gln Pro  Ser Tyr Gln Thr Pro  Pro Ser Leu 
    1520                 1525                 1530             


Pro Asn  His Ile Ser Arg Ala  Pro Ser Pro Ala Ser  Phe Gln Arg 
    1535                 1540                 1545             


Ser Leu  Glu Asn Arg Met Ser  Pro Ser Lys Ser Pro  Phe Leu Pro 
    1550                 1555                 1560             


Ser Met  Lys Met Gln Lys Val  Met Pro Thr Val Pro  Thr Ser Gln 
    1565                 1570                 1575             


Val Thr  Gly Pro Pro Pro Gln  Pro Pro Pro Ile Arg  Arg Glu Ile 
    1580                 1585                 1590             


Thr Phe  Pro Pro Gly Ser Val  Glu Ala Ser Gln Pro  Val Leu Lys 
    1595                 1600                 1605             


Gln Arg  Arg Lys Ile Thr Ser  Lys Asp Ile Val Thr  Pro Glu Ala 
    1610                 1615                 1620             


Trp Arg  Val Met Met Ser Leu  Lys Ser Gly Leu Leu  Ala Glu Ser 
    1625                 1630                 1635             


Thr Trp  Ala Leu Asp Thr Ile  Asn Ile Leu Leu Tyr  Asp Asp Ser 
    1640                 1645                 1650             


Thr Val  Ala Thr Phe Asn Leu  Ser Gln Leu Ser Gly  Phe Leu Glu 
    1655                 1660                 1665             


Leu Leu  Val Glu Tyr Phe Arg  Lys Cys Leu Ile Asp  Ile Phe Gly 
    1670                 1675                 1680             


Ile Leu  Met Glu Tyr Glu Val  Gly Asp Pro Ser Gln  Lys Ala Leu 
    1685                 1690                 1695             


Asp His  Asn Ala Ala Arg Lys  Asp Asp Ser Gln Ser  Leu Ala Asp 
    1700                 1705                 1710             


Asp Ser  Gly Lys Glu Glu Glu  Asp Ala Glu Cys Ile  Asp Asp Asp 
    1715                 1720                 1725             


Glu Glu  Asp Glu Glu Asp Glu  Glu Glu Asp Ser Glu  Lys Thr Glu 
    1730                 1735                 1740             


Ser Asp  Glu Lys Ser Ser Ile  Ala Leu Thr Ala Pro  Asp Ala Ala 
    1745                 1750                 1755             


Ala Asp  Pro Lys Glu Lys Pro  Lys Gln Ala Ser Lys  Phe Asp Lys 
    1760                 1765                 1770             


Leu Pro  Ile Lys Ile Val Lys  Lys Asn Asn Leu Phe  Val Val Asp 
    1775                 1780                 1785             


Arg Ser  Asp Lys Leu Gly Arg  Val Gln Glu Phe Asn  Ser Gly Leu 
    1790                 1795                 1800             


Leu His  Trp Gln Leu Gly Gly  Gly Asp Thr Thr Glu  His Ile Gln 
    1805                 1810                 1815             


Thr His  Phe Glu Ser Lys Met  Glu Ile Pro Pro Arg  Arg Arg Pro 
    1820                 1825                 1830             


Pro Pro  Pro Leu Ser Ser Ala  Gly Arg Lys Lys Glu  Gln Glu Gly 
    1835                 1840                 1845             


Lys Gly  Asp Ser Glu Glu Gln  Gln Glu Lys Ser Ile  Ile Ala Thr 
    1850                 1855                 1860             


Ile Asp  Asp Val Leu Ser Ala  Arg Pro Gly Ala Leu  Pro Glu Asp 
    1865                 1870                 1875             


Ala Asn  Pro Gly Pro Gln Thr  Glu Ser Ser Lys Phe  Pro Phe Gly 
    1880                 1885                 1890             


Ile Gln  Gln Ala Lys Ser His  Arg Asn Ile Lys Leu  Leu Glu Asp 
    1895                 1900                 1905             


Glu Pro  Arg Ser Arg Asp Glu  Thr Pro Leu Cys Thr  Ile Ala His 
    1910                 1915                 1920             


Trp Gln  Asp Ser Leu Ala Lys  Arg Cys Ile Cys Val  Ser Asn Ile 
    1925                 1930                 1935             


Val Arg  Ser Leu Ser Phe Val  Pro Gly Asn Asp Ala  Glu Met Ser 
    1940                 1945                 1950             


Lys His  Pro Gly Leu Val Leu  Ile Leu Gly Lys Leu  Ile Leu Leu 
    1955                 1960                 1965             


His His  Glu His Pro Glu Arg  Lys Arg Ala Pro Gln  Thr Tyr Glu 
    1970                 1975                 1980             


Lys Glu  Glu Asp Glu Asp Lys  Gly Val Ala Cys Ser  Lys Asp Glu 
    1985                 1990                 1995             


Trp Trp  Trp Asp Cys Leu Glu  Val Leu Arg Asp Asn  Thr Leu Val 
    2000                 2005                 2010             


Thr Leu  Ala Asn Ile Ser Gly  Gln Leu Asp Leu Ser  Ala Tyr Thr 
    2015                 2020                 2025             


Glu Ser  Ile Cys Leu Pro Ile  Leu Asp Gly Leu Leu  His Trp Met 
    2030                 2035                 2040             


Val Cys  Pro Ser Ala Glu Ala  Gln Asp Pro Phe Pro  Thr Val Gly 
    2045                 2050                 2055             


Pro Asn  Ser Val Leu Ser Pro  Gln Arg Leu Val Leu  Glu Thr Leu 
    2060                 2065                 2070             


Cys Lys  Leu Ser Ile Gln Asp  Asn Asn Val Asp Leu  Ile Leu Ala 
    2075                 2080                 2085             


Thr Pro  Pro Phe Ser Arg Gln  Glu Lys Phe Tyr Ala  Thr Leu Val 
    2090                 2095                 2100             


Arg Tyr  Val Gly Asp Arg Lys  Asn Pro Val Cys Arg  Glu Met Ser 
    2105                 2110                 2115             


Met Ala  Leu Leu Ser Asn Leu  Ala Gln Gly Asp Ala  Leu Ala Ala 
    2120                 2125                 2130             


Arg Ala  Ile Ala Val Gln Lys  Gly Ser Ile Gly Asn  Leu Ile Ser 
    2135                 2140                 2145             


Phe Leu  Glu Asp Gly Val Thr  Met Ala Gln Tyr Gln  Gln Ser Gln 
    2150                 2155                 2160             


His Asn  Leu Met His Met Gln  Pro Pro Pro Leu Glu  Pro Pro Ser 
    2165                 2170                 2175             


Val Asp  Met Met Cys Arg Ala  Ala Lys Ala Leu Leu  Ala Met Ala 
    2180                 2185                 2190             


Arg Val  Asp Glu Asn Arg Ser  Glu Phe Leu Leu His  Glu Gly Arg 
    2195                 2200                 2205             


Leu Leu  Asp Ile Ser Ile Ser  Ala Val Leu Asn Ser  Leu Val Ala 
    2210                 2215                 2220             


Ser Val  Ile Cys Asp Val Leu  Phe Gln Ile Gly Gln  Leu 
    2225                 2230                 2235     


<210> 54
<211> 9648
<212> DNA
<213> Homo sapiens

<400> 54
atggcccata acgcgggcgc cgcggccgcc gccggcaccc acagcgccaa gagcggcggc       60

tccgaggcgg ctctcaagga gggtggaagc gccgccgcgc tgtcctcctc ctcctcctcc      120

tccgcggcgg cagcggcggc atcctcttcc tcctcgtcgg gcccgggctc ggccatggag      180

acggggctgc tccccaacca caaactgaaa accgttggcg aagcccccgc cgcgccgccc      240

caccagcagc accaccacca ccaccatgcc caccaccacc accaccatgc ccaccacctc      300

caccaccacc acgcactaca gcagcagcta aaccagttcc agcagcagca gcagcagcag      360

caacagcagc agcagcagca gcagcaacag caacatccca tttccaacaa caacagcttg      420

ggcggcgcgg gcggcggcgc gcctcagccc ggccccgaca tggagcagcc gcaacatgga      480

ggcgccaagg acagtgctgc gggcggccag gccgaccccc cgggcccgcc gctgctgagc      540

aagccgggcg acgaggacga cgcgccgccc aagatggggg agccggcggg cggccgctac      600

gagcacccgg gcttgggcgc cctgggcacg cagcagccgc cggtcgccgt gcccgggggc      660

ggcggcggcc cggcggccgt cccggagttt aataattact atggcagcgc tgcccctgcg      720

agcggcggcc ccggcggccg cgctgggcct tgctttgatc aacatggcgg acaacaaagc      780

cccgggatgg ggatgatgca ctccgcctcc gccgccgccg ccggggcccc cggcagcatg      840

gaccccctgc agaactccca cgaagggtac cccaacagcc agtgcaacca ttatccgggc      900

tacagccggc ccggcgcggg cggcggcggc ggcggcggcg gcggaggagg aggaggcagc      960

ggaggaggag gaggaggagg aggagcagga gcaggaggag caggagcggg agctgtggcg     1020

gcggcggccg cggcggcggc ggcagcagca ggaggcggcg gcggcggcgg ctatgggggc     1080

tcgtccgcgg ggtacggggt gctgagctcc ccccggcagc agggcggcgg catgatgatg     1140

ggccccgggg gcggcggggc cgcgagcctc agcaaggcgg ccgccggctc ggcggcgggg     1200

ggcttccagc gcttcgccgg ccagaaccag cacccgtcgg gggccacccc gaccctcaat     1260

cagctgctca cctcgcccag ccccatgatg cggagctacg gcggcagcta ccccgagtac     1320

agcagcccca gcgcgccgcc gccgccgccg tcgcagcccc agtcccaggc ggcggcggcg     1380

ggggcggcgg cgggcggcca gcaggcggcc gcgggcatgg gcttgggcaa ggacatgggc     1440

gcccagtacg ccgctgccag cccggcctgg gcggccgcgc aacaaaggag tcacccggcg     1500

atgagccccg gcacccccgg accgaccatg ggcagatccc agggcagccc aatggatcca     1560

atggtgatga agagacctca gttgtatggc atgggcagta accctcattc tcagcctcag     1620

cagagcagtc cgtacccagg aggttcctat ggccctccag gcccacagcg gtatccaatt     1680

ggcatccagg gtcggactcc cggggccatg gccggaatgc agtaccctca gcagcaggac     1740

tctggagatg ccacatggaa agaaacattc tggttgatgc cacctcagta tggacagcaa     1800

ggtgtgagtg gttactgcca gcagggccaa cagccatatt acagccagca gccgcagccc     1860

ccgcacctcc caccccaggc gcagtatctg ccgtcccagt cccagcagag gtaccagccg     1920

cagcaggaca tgtctcagga aggctatgga actagatctc aacctcctct ggcccccgga     1980

aaacctaacc atgaagactt gaacttaata cagcaagaaa gaccatcaag tttaccagat     2040

ctgtctggct ccattgatga cctccccacg ggaacggaag caactttgag ctcagcagtc     2100

agtgcatccg ggtccacgag cagccaaggg gatcagagca acccggcgca gtcgcctttc     2160

tccccacatg cgtcccctca tctctccagc atcccggggg gcccatctcc ctctcctgtt     2220

ggctctcctg taggaagcaa ccagtctcga tctggcccaa tctctcctgc aagtatccca     2280

ggtagtcaga tgcctccgca gccacccggg agccagtcag aatccagttc ccatcccgcc     2340

ttgagccagt caccaatgcc acaggaaaga ggttttatgg caggcacaca aagaaaccct     2400

cagatggctc agtatggacc tcaacagaca ggaccatcca tgtcgcctca tccttctcct     2460

gggggccaga tgcatgctgg aatcagtagc tttcagcaga gtaactcaag tgggacttac     2520

ggtccacaga tgagccagta tggaccacaa ggtaactact ccagaccccc agcgtatagt     2580

ggggtgccca gtgcaagcta cagcggccca gggcccggta tgggtatcag tgccaacaac     2640

cagatgcatg gacaagggcc aagccagcca tgtggtgctg tgcccctggg acgaatgcca     2700

tcagctggga tgcagaacag accatttcct ggaaatatga gcagcatgac ccccagttct     2760

cctggcatgt ctcagcaggg agggccagga atggggccgc caatgccaac tgtgaaccgt     2820

aaggcacagg aggcagccgc agcagtgatg caggctgctg cgaactcagc acaaagcagg     2880

caaggcagtt tccccggcat gaaccagagt ggacttatgg cttccagctc tccctacagc     2940

cagcccatga acaacagctc tagcctgatg aacacgcagg cgccgcccta cagcatggcg     3000

cccgccatgg tgaacagctc ggcagcatct gtgggtcttg cagatatgat gtctcctggt     3060

gaatccaaac tgcccctgcc tctcaaagca gacggcaaag aagaaggcac tccacagccc     3120

gagagcaagt caaagaagtc cagctcctcc accactactg gggagaagat cacgaaggtg     3180

tacgagctgg ggaatgagcc agagagaaag ctctgggtcg accgatacct caccttcatg     3240

gaagagagag gctctcctgt ctcaagtctg cctgccgtgg gcaagaagcc cctggacctg     3300

ttccgactct acgtctgcgt caaagagatc gggggtttgg cccaggttaa taaaaacaag     3360

aagtggcgtg agctggcaac caacctaaac gttggcacct caagcagtgc agcgagctcc     3420

ctgaaaaagc agtatattca gtacctgttt gcctttgagt gcaagatcga acgtggggag     3480

gagcccccgc cggaagtctt cagcaccggg gacaccaaaa agcagcccaa gctccagccg     3540

ccatctcctg ctaactcggg atccttgcaa ggcccacaga ccccccagtc aactggcagc     3600

aattccatgg cagaggttcc aggtgacctg aagccaccta ccccagcctc cacccctcac     3660

ggccagatga ctccaatgca aggtggaaga agcagtacaa tcagtgtgca cgacccattc     3720

tcagatgtga gtgattcatc cttcccgaaa cggaactcca tgactccaaa cgccccctac     3780

cagcagggca tgagcatgcc cgatgtgatg ggcaggatgc cctatgagcc caacaaggac     3840

ccctttgggg gaatgagaaa agtgcctgga agcagcgagc cctttatgac gcaaggacag     3900

atgcccaaca gcagcatgca ggacatgtac aaccaaagtc cctccggagc aatgtctaac     3960

ctgggcatgg ggcagcgcca gcagtttccc tatggagcca gttacgaccg aaggcatgaa     4020

ccttatgggc agcagtatcc aggccaaggc cctccctcgg gacagccgcc gtatggaggg     4080

caccagcccg gcctgtaccc acagcagccg aattacaaac gccatatgga cggcatgtac     4140

gggcccccag ccaagcgcca cgagggcgac atgtacaaca tgcagtacag cagccagcag     4200

caggagatgt acaaccagta tggaggctcc tactcgggcc cggaccgcag gcccatccag     4260

ggccagtacc cgtatcccta cagcagggag aggatgcagg gcccggggca gatccagaca     4320

cacggaatcc cgcctcagat gatgggcggc ccgctgcagt cgtcctccag tgaggggcct     4380

cagcagaata tgtgggcagc acgcaatgat atgccttatc cctaccagaa caggcagggc     4440

cctggcggcc ctacacaggc gcccccttac ccaggcatga accgcacaga cgatatgatg     4500

gtacccgatc agaggataaa tcatgagagc cagtggcctt ctcacgtcag ccagcgtcag     4560

ccttatatgt cgtcctcagc ctccatgcag cccatcacac gcccaccaca gccgtcctac     4620

cagacgccac cgtcactgcc aaatcacatc tccagggcgc ccagcccagc gtccttccag     4680

cgctccctgg agaaccgcat gtctccaagc aagtctcctt ttctgccgtc tatgaagatg     4740

cagaaggtca tgcccacggt ccccacatcc caggtcaccg ggccaccacc ccaaccaccc     4800

ccaatcagaa gggagatcac ctttcctcct ggctcagtag aagcatcaca accagtcttg     4860

aaacaaaggc gaaagattac ctccaaagat atcgttactc ctgaggcgtg gcgtgtgatg     4920

atgtccctta aatcaggtct tttggctgag agtacgtggg ctttggacac tattaatatt     4980

cttctgtatg atgacagcac tgttgctact ttcaatctct cccagttgtc tggatttctc     5040

gaacttttag tcgagtactt tagaaaatgc ctgattgaca tttttggaat tcttatggaa     5100

tatgaagtgg gagaccccag ccaaaaagca cttgatcaca acgcagcaag gaaggatgac     5160

agccagtcct tggcagacga ttctgggaaa gaggaggaag atgctgaatg tattgatgac     5220

gacgaggaag acgaggagga tgaggaggaa gacagcgaga agacagaaag cgatgaaaag     5280

agcagcatcg ctctgactgc cccggacgcc gctgcagacc caaaggagaa gcccaagcaa     5340

gccagtaagt tcgacaagct gccaataaag atagtcaaaa agaacaacct gtttgttgtt     5400

gaccgatctg acaagttggg gcgtgtgcag gagttcaata gtggccttct gcactggcag     5460

ctcggcgggg gtgacaccac cgagcacatt cagactcact ttgagagcaa gatggaaatt     5520

cctcctcgca ggcgcccacc tcccccctta agctccgcag gtagaaagaa agagcaagaa     5580

ggcaaaggcg actctgaaga gcagcaagag aaaagcatca tagcaaccat cgatgacgtc     5640

ctctctgctc ggccaggggc attgcctgaa gacgcaaacc ctgggcccca gaccgaaagc     5700

agtaagtttc cctttggtat ccagcaagcc aaaagtcacc ggaacatcaa gctgctggag     5760

gacgagccca ggagccgaga cgagactcct ctgtgtacca tcgcgcactg gcaggactcg     5820

ctggctaagc gatgcatctg tgtgtccaat attgtccgta gcttgtcatt cgtgcctggc     5880

aatgatgccg aaatgtccaa acatccaggc ctggtgctga tcctggggaa gctgattctt     5940

cttcaccacg agcatccaga gagaaagcga gcaccgcaga cctatgagaa agaggaggat     6000

gaggacaagg gggtggcctg cagcaaagat gagtggtggt gggactgcct cgaggtcttg     6060

agggataaca cgttggtcac gttggccaac atttccgggc agctagactt gtctgcttac     6120

acggaaagca tctgcttgcc aattttggat ggcttgctgc actggatggt gtgcccgtct     6180

gcagaggcac aagatccctt tccaactgtg ggacccaact cggtcctgtc gcctcagaga     6240

cttgtgctgg agaccctctg taaactcagt atccaggaca ataatgtgga cctgatcttg     6300

gccactcctc catttagtcg tcaggagaaa ttctatgcta cattagttag gtacgttggg     6360

gatcgcaaaa acccagtctg tcgagaaatg tccatggcgc ttttatcgaa ccttgcccaa     6420

ggggacgcac tagcagcaag ggccatagct gtgcagaaag gaagcattgg aaacttgata     6480

agcttcctag aggatggggt cacgatggcc cagtaccagc agagccagca caacctcatg     6540

cacatgcagc ccccgcccct ggaaccacct agcgtagaca tgatgtgcag ggcggccaag     6600

gctttgctag ccatggccag agtggacgaa aaccgctcgg aattcctttt gcacgagggc     6660

cggttgctgg atatctcgat atcagctgtc ctgaactctc tggttgcatc tgtcatctgt     6720

gatgtactgt ttcagattgg gcagttatga cataagtgag aaggcaagca tgtgtgagtg     6780

aagattagag ggtcacatat aactggctgt tttctgttct tgtttatcca gcgtaggaag     6840

aaggaaaaga aaatctttgc tcctctgccc cattcactat ttaccaattg ggaattaaag     6900

aaataattaa tttgaacagt tatgaaatta atatttgctg tctgtgtgta taagtacatc     6960

ctttggggtt ttttttttct ctttttttta accaaagttg ctgtctagtg cattcaaagg     7020

tcactttttg ttcttcacag atctttttaa tgttctttcc catgttgtat tgcatttttg     7080

ggggaagcaa attgacttta aagaaaaaag ttgtggcaaa agatgctaag atgcgaaaat     7140

ttcaccacac tgagtcaaaa aggtgaaaaa ttatccattt cctatgcgtt ttactcctca     7200

gagaatgaaa aaaactgcat cccatcaccc aaagttctgt gcaatagaaa tttctacaga     7260

tacaggtata ggggctcaag gaggtatgtc ggtcagtagt caaaactatg aaatgatact     7320

ggtttctcca caggaatatg gttccattag gctgggagca aaaacaatgt tttttaagat     7380

tgagaataca tacctgacaa cgatccggaa actgctcctc accactcccg tcatgcctgc     7440

tgtcggcgtt tgaccttcca cgtgacagtt cttcacaatt cctttcatca ttttttaaat     7500

atttttttta ctgcctatgg gctgtgatgt atatagaagt tgtacattaa acataccctc     7560

atttttttct tttctttttt tttttttttt ttagtacaaa gttttagttt ctttttcatg     7620

atgtggtaac tacgaagtga tggtagattt aaataatttt ttatttttat tttatatatt     7680

ttttcattag ggccatatct ccaaaaaaag aaagaaaaaa tacaaaaaac aaaaacaaaa     7740

aaaaaagagg gtaatgtaca agtttctgta tgtataaagt catgctcgat ttcaggagag     7800

cagctgatca caatttgctt catgaatcaa ggtgtggaaa tggttatata tggattgatt     7860

tagaaaatgg ttaccagtac agtcaaaaaa gagaaaatga aaaaaataca actaaaagga     7920

agaaacacaa cttcaaagat ttttcagtga tgagaatcca catttgtatt tcaagataat     7980

gtagtttaaa aaaaaaaaaa agaaaaaaac ttgatgtaaa ttcctccttt tcctctggct     8040

taatgaatat catttattca gtataaaatc tttatatgtt ccacatgtta agaataaatg     8100

tacattaaat cttgttaagc actgtgatgg gtgttcttga atactgttct agtttcctta     8160

aagtggtttc ctagtaatca agttatttac aagaaatagg ggaatgcagc agtgtattca     8220

cattataaaa ccctacattt ggaagagacc tttaggggtt acctacttta gagtggggag     8280

caacagtttg attttctcaa attacttagc taattagtct ttctttgaag caattaactc     8340

taacgacatt gaggtatgat cattttcagt atttatggga ggtggctgct gacccacttg     8400

aggtgagatc tcagaagctt aactggcctg aaaatgtaac attctgcctt ttactaactc     8460

catcttagtt taatcaaagt tcaatctatt ccttgtttct tctgtgtgcc tcagagttat     8520

tttgcattta gtttactcca ccgtgtataa tatttatact gtgcaatgtt aaaaaagaat     8580

ctgttatatt gtatgtggtg tacatagtgc aaagtgatga tttctatttc agggcatatt     8640

atggttctca tattccttcc tacctggtgc acagtagctt tttaatacta gtcacttcta     8700

atttaaactt tctcttcctg ggtcattgac tgttactgtg taataatcga tttctttgaa     8760

actgctgcat aattatgctg ttagtggacc tctacctctt ctcttccctc tcccaatcac     8820

agtatactca gaatccccag cccctcgcat acattgtgtc ggttcacatt actcacagta     8880

atatatggaa gagttagaca agaacatgca gttacagtca ttgtgagacg tgactctcca     8940

gtgtcacgag gaaaaaaatc atcttttctg caaacagtct ctcatctgtc aactcccaca     9000

ttactgagtc aaacagtctt cttacataac aatgcaacca aatatatgtt gaattaaaga     9060

cccatttata attctgcttt aaatacatct gcttgctaag aacagatttc agtgctccaa     9120

gcttcaaata tggagatttg taagagggaa ttcaatatta ttctaatttc tctcttacag     9180

agtacaaata aaaggtgtat acaaactccg aacatatcca gtattccaat tcctttgtca     9240

atcagaagag taaaataatt aacaaaagac tgttgttatg gtttgcattg taaccgatac     9300

gcagagtctg accgttgggc aacaagtttt tctatcctga tgcgcaacac agtctctaga     9360

gactaatcca ggaagacttt agcctccttt ccatattctc acccccgaat caagatttac     9420

agaagcccac gaagaattta cagcctgctt gagatcatct tgcctataaa ctgagttatt     9480

gctttgtcct aaaaattagt cggttttttt ttttctatga ggcttttcag aaatttacag     9540

gatgcccaga ctttacatgt gtaccaaaaa aaaaaaaaag ataaaaaata aaggtgcaaa     9600

gaaagtttag tattttggaa tggtgctata aagttgaaaa aaaaaaaa                  9648


<210> 55
<211> 2249
<212> PRT
<213> Homo sapiens

<400> 55
Met Ala His Asn Ala Gly Ala Ala Ala Ala Ala Gly Thr His Ser Ala 
1               5                   10                  15      


Lys Ser Gly Gly Ser Glu Ala Ala Leu Lys Glu Gly Gly Ser Ala Ala 
            20                  25                  30          


Ala Leu Ser Ser Ser Ser Ser Ser Ser Ala Ala Ala Ala Ala Ala Ser 
        35                  40                  45              


Ser Ser Ser Ser Ser Gly Pro Gly Ser Ala Met Glu Thr Gly Leu Leu 
    50                  55                  60                  


Pro Asn His Lys Leu Lys Thr Val Gly Glu Ala Pro Ala Ala Pro Pro 
65                  70                  75                  80  


His Gln Gln His His His His His His Ala His His His His His His 
                85                  90                  95      


Ala His His Leu His His His His Ala Leu Gln Gln Gln Leu Asn Gln 
            100                 105                 110         


Phe Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
        115                 120                 125             


Gln Gln Gln His Pro Ile Ser Asn Asn Asn Ser Leu Gly Gly Ala Gly 
    130                 135                 140                 


Gly Gly Ala Pro Gln Pro Gly Pro Asp Met Glu Gln Pro Gln His Gly 
145                 150                 155                 160 


Gly Ala Lys Asp Ser Ala Ala Gly Gly Gln Ala Asp Pro Pro Gly Pro 
                165                 170                 175     


Pro Leu Leu Ser Lys Pro Gly Asp Glu Asp Asp Ala Pro Pro Lys Met 
            180                 185                 190         


Gly Glu Pro Ala Gly Gly Arg Tyr Glu His Pro Gly Leu Gly Ala Leu 
        195                 200                 205             


Gly Thr Gln Gln Pro Pro Val Ala Val Pro Gly Gly Gly Gly Gly Pro 
    210                 215                 220                 


Ala Ala Val Pro Glu Phe Asn Asn Tyr Tyr Gly Ser Ala Ala Pro Ala 
225                 230                 235                 240 


Ser Gly Gly Pro Gly Gly Arg Ala Gly Pro Cys Phe Asp Gln His Gly 
                245                 250                 255     


Gly Gln Gln Ser Pro Gly Met Gly Met Met His Ser Ala Ser Ala Ala 
            260                 265                 270         


Ala Ala Gly Ala Pro Gly Ser Met Asp Pro Leu Gln Asn Ser His Glu 
        275                 280                 285             


Gly Tyr Pro Asn Ser Gln Cys Asn His Tyr Pro Gly Tyr Ser Arg Pro 
    290                 295                 300                 


Gly Ala Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Ser 
305                 310                 315                 320 


Gly Gly Gly Gly Gly Gly Gly Gly Ala Gly Ala Gly Gly Ala Gly Ala 
                325                 330                 335     


Gly Ala Val Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Gly Gly 
            340                 345                 350         


Gly Gly Gly Gly Gly Tyr Gly Gly Ser Ser Ala Gly Tyr Gly Val Leu 
        355                 360                 365             


Ser Ser Pro Arg Gln Gln Gly Gly Gly Met Met Met Gly Pro Gly Gly 
    370                 375                 380                 


Gly Gly Ala Ala Ser Leu Ser Lys Ala Ala Ala Gly Ser Ala Ala Gly 
385                 390                 395                 400 


Gly Phe Gln Arg Phe Ala Gly Gln Asn Gln His Pro Ser Gly Ala Thr 
                405                 410                 415     


Pro Thr Leu Asn Gln Leu Leu Thr Ser Pro Ser Pro Met Met Arg Ser 
            420                 425                 430         


Tyr Gly Gly Ser Tyr Pro Glu Tyr Ser Ser Pro Ser Ala Pro Pro Pro 
        435                 440                 445             


Pro Pro Ser Gln Pro Gln Ser Gln Ala Ala Ala Ala Gly Ala Ala Ala 
    450                 455                 460                 


Gly Gly Gln Gln Ala Ala Ala Gly Met Gly Leu Gly Lys Asp Met Gly 
465                 470                 475                 480 


Ala Gln Tyr Ala Ala Ala Ser Pro Ala Trp Ala Ala Ala Gln Gln Arg 
                485                 490                 495     


Ser His Pro Ala Met Ser Pro Gly Thr Pro Gly Pro Thr Met Gly Arg 
            500                 505                 510         


Ser Gln Gly Ser Pro Met Asp Pro Met Val Met Lys Arg Pro Gln Leu 
        515                 520                 525             


Tyr Gly Met Gly Ser Asn Pro His Ser Gln Pro Gln Gln Ser Ser Pro 
    530                 535                 540                 


Tyr Pro Gly Gly Ser Tyr Gly Pro Pro Gly Pro Gln Arg Tyr Pro Ile 
545                 550                 555                 560 


Gly Ile Gln Gly Arg Thr Pro Gly Ala Met Ala Gly Met Gln Tyr Pro 
                565                 570                 575     


Gln Gln Gln Asp Ser Gly Asp Ala Thr Trp Lys Glu Thr Phe Trp Leu 
            580                 585                 590         


Met Pro Pro Gln Tyr Gly Gln Gln Gly Val Ser Gly Tyr Cys Gln Gln 
        595                 600                 605             


Gly Gln Gln Pro Tyr Tyr Ser Gln Gln Pro Gln Pro Pro His Leu Pro 
    610                 615                 620                 


Pro Gln Ala Gln Tyr Leu Pro Ser Gln Ser Gln Gln Arg Tyr Gln Pro 
625                 630                 635                 640 


Gln Gln Asp Met Ser Gln Glu Gly Tyr Gly Thr Arg Ser Gln Pro Pro 
                645                 650                 655     


Leu Ala Pro Gly Lys Pro Asn His Glu Asp Leu Asn Leu Ile Gln Gln 
            660                 665                 670         


Glu Arg Pro Ser Ser Leu Pro Asp Leu Ser Gly Ser Ile Asp Asp Leu 
        675                 680                 685             


Pro Thr Gly Thr Glu Ala Thr Leu Ser Ser Ala Val Ser Ala Ser Gly 
    690                 695                 700                 


Ser Thr Ser Ser Gln Gly Asp Gln Ser Asn Pro Ala Gln Ser Pro Phe 
705                 710                 715                 720 


Ser Pro His Ala Ser Pro His Leu Ser Ser Ile Pro Gly Gly Pro Ser 
                725                 730                 735     


Pro Ser Pro Val Gly Ser Pro Val Gly Ser Asn Gln Ser Arg Ser Gly 
            740                 745                 750         


Pro Ile Ser Pro Ala Ser Ile Pro Gly Ser Gln Met Pro Pro Gln Pro 
        755                 760                 765             


Pro Gly Ser Gln Ser Glu Ser Ser Ser His Pro Ala Leu Ser Gln Ser 
    770                 775                 780                 


Pro Met Pro Gln Glu Arg Gly Phe Met Ala Gly Thr Gln Arg Asn Pro 
785                 790                 795                 800 


Gln Met Ala Gln Tyr Gly Pro Gln Gln Thr Gly Pro Ser Met Ser Pro 
                805                 810                 815     


His Pro Ser Pro Gly Gly Gln Met His Ala Gly Ile Ser Ser Phe Gln 
            820                 825                 830         


Gln Ser Asn Ser Ser Gly Thr Tyr Gly Pro Gln Met Ser Gln Tyr Gly 
        835                 840                 845             


Pro Gln Gly Asn Tyr Ser Arg Pro Pro Ala Tyr Ser Gly Val Pro Ser 
    850                 855                 860                 


Ala Ser Tyr Ser Gly Pro Gly Pro Gly Met Gly Ile Ser Ala Asn Asn 
865                 870                 875                 880 


Gln Met His Gly Gln Gly Pro Ser Gln Pro Cys Gly Ala Val Pro Leu 
                885                 890                 895     


Gly Arg Met Pro Ser Ala Gly Met Gln Asn Arg Pro Phe Pro Gly Asn 
            900                 905                 910         


Met Ser Ser Met Thr Pro Ser Ser Pro Gly Met Ser Gln Gln Gly Gly 
        915                 920                 925             


Pro Gly Met Gly Pro Pro Met Pro Thr Val Asn Arg Lys Ala Gln Glu 
    930                 935                 940                 


Ala Ala Ala Ala Val Met Gln Ala Ala Ala Asn Ser Ala Gln Ser Arg 
945                 950                 955                 960 


Gln Gly Ser Phe Pro Gly Met Asn Gln Ser Gly Leu Met Ala Ser Ser 
                965                 970                 975     


Ser Pro Tyr Ser Gln Pro Met Asn Asn Ser Ser Ser Leu Met Asn Thr 
            980                 985                 990         


Gln Ala Pro Pro Tyr Ser Met Ala  Pro Ala Met Val Asn  Ser Ser Ala 
        995                 1000                 1005             


Ala Ser  Val Gly Leu Ala Asp  Met Met Ser Pro Gly  Glu Ser Lys 
    1010                 1015                 1020             


Leu Pro  Leu Pro Leu Lys Ala  Asp Gly Lys Glu Glu  Gly Thr Pro 
    1025                 1030                 1035             


Gln Pro  Glu Ser Lys Ser Lys  Lys Ser Ser Ser Ser  Thr Thr Thr 
    1040                 1045                 1050             


Gly Glu  Lys Ile Thr Lys Val  Tyr Glu Leu Gly Asn  Glu Pro Glu 
    1055                 1060                 1065             


Arg Lys  Leu Trp Val Asp Arg  Tyr Leu Thr Phe Met  Glu Glu Arg 
    1070                 1075                 1080             


Gly Ser  Pro Val Ser Ser Leu  Pro Ala Val Gly Lys  Lys Pro Leu 
    1085                 1090                 1095             


Asp Leu  Phe Arg Leu Tyr Val  Cys Val Lys Glu Ile  Gly Gly Leu 
    1100                 1105                 1110             


Ala Gln  Val Asn Lys Asn Lys  Lys Trp Arg Glu Leu  Ala Thr Asn 
    1115                 1120                 1125             


Leu Asn  Val Gly Thr Ser Ser  Ser Ala Ala Ser Ser  Leu Lys Lys 
    1130                 1135                 1140             


Gln Tyr  Ile Gln Tyr Leu Phe  Ala Phe Glu Cys Lys  Ile Glu Arg 
    1145                 1150                 1155             


Gly Glu  Glu Pro Pro Pro Glu  Val Phe Ser Thr Gly  Asp Thr Lys 
    1160                 1165                 1170             


Lys Gln  Pro Lys Leu Gln Pro  Pro Ser Pro Ala Asn  Ser Gly Ser 
    1175                 1180                 1185             


Leu Gln  Gly Pro Gln Thr Pro  Gln Ser Thr Gly Ser  Asn Ser Met 
    1190                 1195                 1200             


Ala Glu  Val Pro Gly Asp Leu  Lys Pro Pro Thr Pro  Ala Ser Thr 
    1205                 1210                 1215             


Pro His  Gly Gln Met Thr Pro  Met Gln Gly Gly Arg  Ser Ser Thr 
    1220                 1225                 1230             


Ile Ser  Val His Asp Pro Phe  Ser Asp Val Ser Asp  Ser Ser Phe 
    1235                 1240                 1245             


Pro Lys  Arg Asn Ser Met Thr  Pro Asn Ala Pro Tyr  Gln Gln Gly 
    1250                 1255                 1260             


Met Ser  Met Pro Asp Val Met  Gly Arg Met Pro Tyr  Glu Pro Asn 
    1265                 1270                 1275             


Lys Asp  Pro Phe Gly Gly Met  Arg Lys Val Pro Gly  Ser Ser Glu 
    1280                 1285                 1290             


Pro Phe  Met Thr Gln Gly Gln  Met Pro Asn Ser Ser  Met Gln Asp 
    1295                 1300                 1305             


Met Tyr  Asn Gln Ser Pro Ser  Gly Ala Met Ser Asn  Leu Gly Met 
    1310                 1315                 1320             


Gly Gln  Arg Gln Gln Phe Pro  Tyr Gly Ala Ser Tyr  Asp Arg Arg 
    1325                 1330                 1335             


His Glu  Pro Tyr Gly Gln Gln  Tyr Pro Gly Gln Gly  Pro Pro Ser 
    1340                 1345                 1350             


Gly Gln  Pro Pro Tyr Gly Gly  His Gln Pro Gly Leu  Tyr Pro Gln 
    1355                 1360                 1365             


Gln Pro  Asn Tyr Lys Arg His  Met Asp Gly Met Tyr  Gly Pro Pro 
    1370                 1375                 1380             


Ala Lys  Arg His Glu Gly Asp  Met Tyr Asn Met Gln  Tyr Ser Ser 
    1385                 1390                 1395             


Gln Gln  Gln Glu Met Tyr Asn  Gln Tyr Gly Gly Ser  Tyr Ser Gly 
    1400                 1405                 1410             


Pro Asp  Arg Arg Pro Ile Gln  Gly Gln Tyr Pro Tyr  Pro Tyr Ser 
    1415                 1420                 1425             


Arg Glu  Arg Met Gln Gly Pro  Gly Gln Ile Gln Thr  His Gly Ile 
    1430                 1435                 1440             


Pro Pro  Gln Met Met Gly Gly  Pro Leu Gln Ser Ser  Ser Ser Glu 
    1445                 1450                 1455             


Gly Pro  Gln Gln Asn Met Trp  Ala Ala Arg Asn Asp  Met Pro Tyr 
    1460                 1465                 1470             


Pro Tyr  Gln Asn Arg Gln Gly  Pro Gly Gly Pro Thr  Gln Ala Pro 
    1475                 1480                 1485             


Pro Tyr  Pro Gly Met Asn Arg  Thr Asp Asp Met Met  Val Pro Asp 
    1490                 1495                 1500             


Gln Arg  Ile Asn His Glu Ser  Gln Trp Pro Ser His  Val Ser Gln 
    1505                 1510                 1515             


Arg Gln  Pro Tyr Met Ser Ser  Ser Ala Ser Met Gln  Pro Ile Thr 
    1520                 1525                 1530             


Arg Pro  Pro Gln Pro Ser Tyr  Gln Thr Pro Pro Ser  Leu Pro Asn 
    1535                 1540                 1545             


His Ile  Ser Arg Ala Pro Ser  Pro Ala Ser Phe Gln  Arg Ser Leu 
    1550                 1555                 1560             


Glu Asn  Arg Met Ser Pro Ser  Lys Ser Pro Phe Leu  Pro Ser Met 
    1565                 1570                 1575             


Lys Met  Gln Lys Val Met Pro  Thr Val Pro Thr Ser  Gln Val Thr 
    1580                 1585                 1590             


Gly Pro  Pro Pro Gln Pro Pro  Pro Ile Arg Arg Glu  Ile Thr Phe 
    1595                 1600                 1605             


Pro Pro  Gly Ser Val Glu Ala  Ser Gln Pro Val Leu  Lys Gln Arg 
    1610                 1615                 1620             


Arg Lys  Ile Thr Ser Lys Asp  Ile Val Thr Pro Glu  Ala Trp Arg 
    1625                 1630                 1635             


Val Met  Met Ser Leu Lys Ser  Gly Leu Leu Ala Glu  Ser Thr Trp 
    1640                 1645                 1650             


Ala Leu  Asp Thr Ile Asn Ile  Leu Leu Tyr Asp Asp  Ser Thr Val 
    1655                 1660                 1665             


Ala Thr  Phe Asn Leu Ser Gln  Leu Ser Gly Phe Leu  Glu Leu Leu 
    1670                 1675                 1680             


Val Glu  Tyr Phe Arg Lys Cys  Leu Ile Asp Ile Phe  Gly Ile Leu 
    1685                 1690                 1695             


Met Glu  Tyr Glu Val Gly Asp  Pro Ser Gln Lys Ala  Leu Asp His 
    1700                 1705                 1710             


Asn Ala  Ala Arg Lys Asp Asp  Ser Gln Ser Leu Ala  Asp Asp Ser 
    1715                 1720                 1725             


Gly Lys  Glu Glu Glu Asp Ala  Glu Cys Ile Asp Asp  Asp Glu Glu 
    1730                 1735                 1740             


Asp Glu  Glu Asp Glu Glu Glu  Asp Ser Glu Lys Thr  Glu Ser Asp 
    1745                 1750                 1755             


Glu Lys  Ser Ser Ile Ala Leu  Thr Ala Pro Asp Ala  Ala Ala Asp 
    1760                 1765                 1770             


Pro Lys  Glu Lys Pro Lys Gln  Ala Ser Lys Phe Asp  Lys Leu Pro 
    1775                 1780                 1785             


Ile Lys  Ile Val Lys Lys Asn  Asn Leu Phe Val Val  Asp Arg Ser 
    1790                 1795                 1800             


Asp Lys  Leu Gly Arg Val Gln  Glu Phe Asn Ser Gly  Leu Leu His 
    1805                 1810                 1815             


Trp Gln  Leu Gly Gly Gly Asp  Thr Thr Glu His Ile  Gln Thr His 
    1820                 1825                 1830             


Phe Glu  Ser Lys Met Glu Ile  Pro Pro Arg Arg Arg  Pro Pro Pro 
    1835                 1840                 1845             


Pro Leu  Ser Ser Ala Gly Arg  Lys Lys Glu Gln Glu  Gly Lys Gly 
    1850                 1855                 1860             


Asp Ser  Glu Glu Gln Gln Glu  Lys Ser Ile Ile Ala  Thr Ile Asp 
    1865                 1870                 1875             


Asp Val  Leu Ser Ala Arg Pro  Gly Ala Leu Pro Glu  Asp Ala Asn 
    1880                 1885                 1890             


Pro Gly  Pro Gln Thr Glu Ser  Ser Lys Phe Pro Phe  Gly Ile Gln 
    1895                 1900                 1905             


Gln Ala  Lys Ser His Arg Asn  Ile Lys Leu Leu Glu  Asp Glu Pro 
    1910                 1915                 1920             


Arg Ser  Arg Asp Glu Thr Pro  Leu Cys Thr Ile Ala  His Trp Gln 
    1925                 1930                 1935             


Asp Ser  Leu Ala Lys Arg Cys  Ile Cys Val Ser Asn  Ile Val Arg 
    1940                 1945                 1950             


Ser Leu  Ser Phe Val Pro Gly  Asn Asp Ala Glu Met  Ser Lys His 
    1955                 1960                 1965             


Pro Gly  Leu Val Leu Ile Leu  Gly Lys Leu Ile Leu  Leu His His 
    1970                 1975                 1980             


Glu His  Pro Glu Arg Lys Arg  Ala Pro Gln Thr Tyr  Glu Lys Glu 
    1985                 1990                 1995             


Glu Asp  Glu Asp Lys Gly Val  Ala Cys Ser Lys Asp  Glu Trp Trp 
    2000                 2005                 2010             


Trp Asp  Cys Leu Glu Val Leu  Arg Asp Asn Thr Leu  Val Thr Leu 
    2015                 2020                 2025             


Ala Asn  Ile Ser Gly Gln Leu  Asp Leu Ser Ala Tyr  Thr Glu Ser 
    2030                 2035                 2040             


Ile Cys  Leu Pro Ile Leu Asp  Gly Leu Leu His Trp  Met Val Cys 
    2045                 2050                 2055             


Pro Ser  Ala Glu Ala Gln Asp  Pro Phe Pro Thr Val  Gly Pro Asn 
    2060                 2065                 2070             


Ser Val  Leu Ser Pro Gln Arg  Leu Val Leu Glu Thr  Leu Cys Lys 
    2075                 2080                 2085             


Leu Ser  Ile Gln Asp Asn Asn  Val Asp Leu Ile Leu  Ala Thr Pro 
    2090                 2095                 2100             


Pro Phe  Ser Arg Gln Glu Lys  Phe Tyr Ala Thr Leu  Val Arg Tyr 
    2105                 2110                 2115             


Val Gly  Asp Arg Lys Asn Pro  Val Cys Arg Glu Met  Ser Met Ala 
    2120                 2125                 2130             


Leu Leu  Ser Asn Leu Ala Gln  Gly Asp Ala Leu Ala  Ala Arg Ala 
    2135                 2140                 2145             


Ile Ala  Val Gln Lys Gly Ser  Ile Gly Asn Leu Ile  Ser Phe Leu 
    2150                 2155                 2160             


Glu Asp  Gly Val Thr Met Ala  Gln Tyr Gln Gln Ser  Gln His Asn 
    2165                 2170                 2175             


Leu Met  His Met Gln Pro Pro  Pro Leu Glu Pro Pro  Ser Val Asp 
    2180                 2185                 2190             


Met Met  Cys Arg Ala Ala Lys  Ala Leu Leu Ala Met  Ala Arg Val 
    2195                 2200                 2205             


Asp Glu  Asn Arg Ser Glu Phe  Leu Leu His Glu Gly  Arg Leu Leu 
    2210                 2215                 2220             


Asp Ile  Ser Ile Ser Ala Val  Leu Asn Ser Leu Val  Ala Ser Val 
    2225                 2230                 2235             


Ile Cys  Asp Val Leu Phe Gln  Ile Gly Gln Leu 
    2240                 2245                 


<210> 56
<211> 9833
<212> DNA
<213> Homo sapiens

<400> 56
gggggcggcg gcgacggcgg cggcggcctg aacagtgtgc accaccaccc cctgctcccc       60

cgtcacgaac tcaacatggc ccataacgcg ggcgccgcgg ccgccgccgg cacccacagc      120

gccaagagcg gcggctccga ggcggctctc aaggagggtg gaagcgccgc cgcgctgtcc      180

tcctcctcct cctcctccgc ggcggcagcg gcggcatcct cttcctcctc gtcgggcccg      240

ggctcggcca tggagacggg gctgctcccc aaccacaaac tgaaaaccgt tggcgaagcc      300

cccgccgcgc cgccccacca gcagcaccac caccaccacc atgcccacca ccaccaccac      360

catgcccacc acctccacca ccaccacgca ctacagcagc agctaaacca gttccagcag      420

cagcagcagc agcagcaaca gcagcagcag cagcagcagc aacagcaaca tcccatttcc      480

aacaacaaca gcttgggcgg cgcgggcggc ggcgcgcctc agcccggccc cgacatggag      540

cagccgcaac atggaggcgc caaggacagt gctgcgggcg gccaggccga ccccccgggc      600

ccgccgctgc tgagcaagcc gggcgacgag gacgacgcgc cgcccaagat gggggagccg      660

gcgggcggcc gctacgagca cccgggcttg ggcgccctgg gcacgcagca gccgccggtc      720

gccgtgcccg ggggcggcgg cggcccggcg gccgtcccgg agtttaataa ttactatggc      780

agcgctgccc ctgcgagcgg cggccccggc ggccgcgctg ggccttgctt tgatcaacat      840

ggcggacaac aaagccccgg gatggggatg atgcactccg cctccgccgc cgccgccggg      900

gcccccggca gcatggaccc cctgcagaac tcccacgaag ggtaccccaa cagccagtgc      960

aaccattatc cgggctacag ccggcccggc gcgggcggcg gcggcggcgg cggcggcgga     1020

ggaggaggag gcagcggagg aggaggagga ggaggaggag caggagcagg aggagcagga     1080

gcgggagctg tggcggcggc ggccgcggcg gcggcggcag cagcaggagg cggcggcggc     1140

ggcggctatg ggggctcgtc cgcggggtac ggggtgctga gctccccccg gcagcagggc     1200

ggcggcatga tgatgggccc cgggggcggc ggggccgcga gcctcagcaa ggcggccgcc     1260

ggctcggcgg cggggggctt ccagcgcttc gccggccaga accagcaccc gtcgggggcc     1320

accccgaccc tcaatcagct gctcacctcg cccagcccca tgatgcggag ctacggcggc     1380

agctaccccg agtacagcag ccccagcgcg ccgccgccgc cgccgtcgca gccccagtcc     1440

caggcggcgg cggcgggggc ggcggcgggc ggccagcagg cggccgcggg catgggcttg     1500

ggcaaggaca tgggcgccca gtacgccgct gccagcccgg cctgggcggc cgcgcaacaa     1560

aggagtcacc cggcgatgag ccccggcacc cccggaccga ccatgggcag atcccagggc     1620

agcccaatgg atccaatggt gatgaagaga cctcagttgt atggcatggg cagtaaccct     1680

cattctcagc ctcagcagag cagtccgtac ccaggaggtt cctatggccc tccaggccca     1740

cagcggtatc caattggcat ccagggtcgg actcccgggg ccatggccgg aatgcagtac     1800

cctcagcagc agatgccacc tcagtatgga cagcaaggtg tgagtggtta ctgccagcag     1860

ggccaacagc catattacag ccagcagccg cagcccccgc acctcccacc ccaggcgcag     1920

tatctgccgt cccagtccca gcagaggtac cagccgcagc aggacatgtc tcaggaaggc     1980

tatggaacta gatctcaacc tcctctggcc cccggaaaac ctaaccatga agacttgaac     2040

ttaatacagc aagaaagacc atcaagttta ccagatctgt ctggctccat tgatgacctc     2100

cccacgggaa cggaagcaac tttgagctca gcagtcagtg catccgggtc cacgagcagc     2160

caaggggatc agagcaaccc ggcgcagtcg cctttctccc cacatgcgtc ccctcatctc     2220

tccagcatcc cggggggccc atctccctct cctgttggct ctcctgtagg aagcaaccag     2280

tctcgatctg gcccaatctc tcctgcaagt atcccaggta gtcagatgcc tccgcagcca     2340

cccgggagcc agtcagaatc cagttcccat cccgccttga gccagtcacc aatgccacag     2400

gaaagaggtt ttatggcagg cacacaaaga aaccctcaga tggctcagta tggacctcaa     2460

cagacaggac catccatgtc gcctcatcct tctcctgggg gccagatgca tgctggaatc     2520

agtagctttc agcagagtaa ctcaagtggg acttacggtc cacagatgag ccagtatgga     2580

ccacaaggta actactccag acccccagcg tatagtgggg tgcccagtgc aagctacagc     2640

ggcccagggc ccggtatggg tatcagtgcc aacaaccaga tgcatggaca agggccaagc     2700

cagccatgtg gtgctgtgcc cctgggacga atgccatcag ctgggatgca gaacagacca     2760

tttcctggaa atatgagcag catgaccccc agttctcctg gcatgtctca gcagggaggg     2820

ccaggaatgg ggccgccaat gccaactgtg aaccgtaagg cacaggaggc agccgcagca     2880

gtgatgcagg ctgctgcgaa ctcagcacaa agcaggcaag gcagtttccc cggcatgaac     2940

cagagtggac ttatggcttc cagctctccc tacagccagc ccatgaacaa cagctctagc     3000

ctgatgaaca cgcaggcgcc gccctacagc atggcgcccg ccatggtgaa cagctcggca     3060

gcatctgtgg gtcttgcaga tatgatgtct cctggtgaat ccaaactgcc cctgcctctc     3120

aaagcagacg gcaaagaaga aggcactcca cagcccgaga gcaagtcaaa ggatagctac     3180

agctctcagg gtatttctca gcccccaacc ccaggcaacc tgccagtccc ttccccaatg     3240

tcccccagct ctgctagcat ctcctcattt catggagatg aaagtgatag cattagcagc     3300

ccaggctggc caaagactcc atcaagccct aagtccagct cctccaccac tactggggag     3360

aagatcacga aggtgtacga gctggggaat gagccagaga gaaagctctg ggtcgaccga     3420

tacctcacct tcatggaaga gagaggctct cctgtctcaa gtctgcctgc cgtgggcaag     3480

aagcccctgg acctgttccg actctacgtc tgcgtcaaag agatcggggg tttggcccag     3540

gttaataaaa acaagaagtg gcgtgagctg gcaaccaacc taaacgttgg cacctcaagc     3600

agtgcagcga gctccctgaa aaagcagtat attcagtacc tgtttgcctt tgagtgcaag     3660

atcgaacgtg gggaggagcc cccgccggaa gtcttcagca ccggggacac caaaaagcag     3720

cccaagctcc agccgccatc tcctgctaac tcgggatcct tgcaaggccc acagaccccc     3780

cagtcaactg gcagcaattc catggcagag gttccaggtg acctgaagcc acctacccca     3840

gcctccaccc ctcacggcca gatgactcca atgcaaggtg gaagaagcag tacaatcagt     3900

gtgcacgacc cattctcaga tgtgagtgat tcatccttcc cgaaacggaa ctccatgact     3960

ccaaacgccc cctaccagca gggcatgagc atgcccgatg tgatgggcag gatgccctat     4020

gagcccaaca aggacccctt tgggggaatg agaaaagtgc ctggaagcag cgagcccttt     4080

atgacgcaag gacagatgcc caacagcagc atgcaggaca tgtacaacca aagtccctcc     4140

ggagcaatgt ctaacctggg catggggcag cgccagcagt ttccctatgg agccagttac     4200

gaccgaaggc atgaacctta tgggcagcag tatccaggcc aaggccctcc ctcgggacag     4260

ccgccgtatg gagggcacca gcccggcctg tacccacagc agccgaatta caaacgccat     4320

atggacggca tgtacgggcc cccagccaag cgccacgagg gcgacatgta caacatgcag     4380

tacagcagcc agcagcagga gatgtacaac cagtatggag gctcctactc gggcccggac     4440

cgcaggccca tccagggcca gtacccgtat ccctacagca gggagaggat gcagggcccg     4500

gggcagatcc agacacacgg aatcccgcct cagatgatgg gcggcccgct gcagtcgtcc     4560

tccagtgagg ggcctcagca gaatatgtgg gcagcacgca atgatatgcc ttatccctac     4620

cagaacaggc agggccctgg cggccctaca caggcgcccc cttacccagg catgaaccgc     4680

acagacgata tgatggtacc cgatcagagg ataaatcatg agagccagtg gccttctcac     4740

gtcagccagc gtcagcctta tatgtcgtcc tcagcctcca tgcagcccat cacacgccca     4800

ccacagccgt cctaccagac gccaccgtca ctgccaaatc acatctccag ggcgcccagc     4860

ccagcgtcct tccagcgctc cctggagaac cgcatgtctc caagcaagtc tccttttctg     4920

ccgtctatga agatgcagaa ggtcatgccc acggtcccca catcccaggt caccgggcca     4980

ccaccccaac cacccccaat cagaagggag atcacctttc ctcctggctc agtagaagca     5040

tcacaaccag tcttgaaaca aaggcgaaag attacctcca aagatatcgt tactcctgag     5100

gcgtggcgtg tgatgatgtc ccttaaatca ggtcttttgg ctgagagtac gtgggctttg     5160

gacactatta atattcttct gtatgatgac agcactgttg ctactttcaa tctctcccag     5220

ttgtctggat ttctcgaact tttagtcgag tactttagaa aatgcctgat tgacattttt     5280

ggaattctta tggaatatga agtgggagac cccagccaaa aagcacttga tcacaacgca     5340

gcaaggaagg atgacagcca gtccttggca gacgattctg ggaaagagga ggaagatgct     5400

gaatgtattg atgacgacga ggaagacgag gaggatgagg aggaagacag cgagaagaca     5460

gaaagcgatg aaaagagcag catcgctctg actgccccgg acgccgctgc agacccaaag     5520

gagaagccca agcaagccag taagttcgac aagctgccaa taaagatagt caaaaagaac     5580

aacctgtttg ttgttgaccg atctgacaag ttggggcgtg tgcaggagtt caatagtggc     5640

cttctgcact ggcagctcgg cgggggtgac accaccgagc acattcagac tcactttgag     5700

agcaagatgg aaattcctcc tcgcaggcgc ccacctcccc ccttaagctc cgcaggtaga     5760

aagaaagagc aagaaggcaa aggcgactct gaagagcagc aagagaaaag catcatagca     5820

accatcgatg acgtcctctc tgctcggcca ggggcattgc ctgaagacgc aaaccctggg     5880

ccccagaccg aaagcagtaa gtttcccttt ggtatccagc aagccaaaag tcaccggaac     5940

atcaagctgc tggaggacga gcccaggagc cgagacgaga ctcctctgtg taccatcgcg     6000

cactggcagg actcgctggc taagcgatgc atctgtgtgt ccaatattgt ccgtagcttg     6060

tcattcgtgc ctggcaatga tgccgaaatg tccaaacatc caggcctggt gctgatcctg     6120

gggaagctga ttcttcttca ccacgagcat ccagagagaa agcgagcacc gcagacctat     6180

gagaaagagg aggatgagga caagggggtg gcctgcagca aagatgagtg gtggtgggac     6240

tgcctcgagg tcttgaggga taacacgttg gtcacgttgg ccaacatttc cgggcagcta     6300

gacttgtctg cttacacgga aagcatctgc ttgccaattt tggatggctt gctgcactgg     6360

atggtgtgcc cgtctgcaga ggcacaagat ccctttccaa ctgtgggacc caactcggtc     6420

ctgtcgcctc agagacttgt gctggagacc ctctgtaaac tcagtatcca ggacaataat     6480

gtggacctga tcttggccac tcctccattt agtcgtcagg agaaattcta tgctacatta     6540

gttaggtacg ttggggatcg caaaaaccca gtctgtcgag aaatgtccat ggcgctttta     6600

tcgaaccttg cccaagggga cgcactagca gcaagggcca tagctgtgca gaaaggaagc     6660

attggaaact tgataagctt cctagaggat ggggtcacga tggcccagta ccagcagagc     6720

cagcacaacc tcatgcacat gcagcccccg cccctggaac cacctagcgt agacatgatg     6780

tgcagggcgg ccaaggcttt gctagccatg gccagagtgg acgaaaaccg ctcggaattc     6840

cttttgcacg agggccggtt gctggatatc tcgatatcag ctgtcctgaa ctctctggtt     6900

gcatctgtca tctgtgatgt actgtttcag attgggcagt tatgacataa gtgagaaggc     6960

aagcatgtgt gagtgaagat tagagggtca catataactg gctgttttct gttcttgttt     7020

atccagcgta ggaagaagga aaagaaaatc tttgctcctc tgccccattc actatttacc     7080

aattgggaat taaagaaata attaatttga acagttatga aattaatatt tgctgtctgt     7140

gtgtataagt acatcctttg gggttttttt tttctctttt ttttaaccaa agttgctgtc     7200

tagtgcattc aaaggtcact ttttgttctt cacagatctt tttaatgttc tttcccatgt     7260

tgtattgcat ttttggggga agcaaattga ctttaaagaa aaaagttgtg gcaaaagatg     7320

ctaagatgcg aaaatttcac cacactgagt caaaaaggtg aaaaattatc catttcctat     7380

gcgttttact cctcagagaa tgaaaaaaac tgcatcccat cacccaaagt tctgtgcaat     7440

agaaatttct acagatacag gtataggggc tcaaggaggt atgtcggtca gtagtcaaaa     7500

ctatgaaatg atactggttt ctccacagga atatggttcc attaggctgg gagcaaaaac     7560

aatgtttttt aagattgaga atacatacct gacaacgatc cggaaactgc tcctcaccac     7620

tcccgtcatg cctgctgtcg gcgtttgacc ttccacgtga cagttcttca caattccttt     7680

catcattttt taaatatttt ttttactgcc tatgggctgt gatgtatata gaagttgtac     7740

attaaacata ccctcatttt tttcttttct tttttttttt tttttttagt acaaagtttt     7800

agtttctttt tcatgatgtg gtaactacga agtgatggta gatttaaata attttttatt     7860

tttattttat atattttttc attagggcca tatctccaaa aaaagaaaga aaaaatacaa     7920

aaaacaaaaa caaaaaaaaa agagggtaat gtacaagttt ctgtatgtat aaagtcatgc     7980

tcgatttcag gagagcagct gatcacaatt tgcttcatga atcaaggtgt ggaaatggtt     8040

atatatggat tgatttagaa aatggttacc agtacagtca aaaaagagaa aatgaaaaaa     8100

atacaactaa aaggaagaaa cacaacttca aagatttttc agtgatgaga atccacattt     8160

gtatttcaag ataatgtagt ttaaaaaaaa aaaaaagaaa aaaacttgat gtaaattcct     8220

ccttttcctc tggcttaatg aatatcattt attcagtata aaatctttat atgttccaca     8280

tgttaagaat aaatgtacat taaatcttgt taagcactgt gatgggtgtt cttgaatact     8340

gttctagttt ccttaaagtg gtttcctagt aatcaagtta tttacaagaa ataggggaat     8400

gcagcagtgt attcacatta taaaacccta catttggaag agacctttag gggttaccta     8460

ctttagagtg gggagcaaca gtttgatttt ctcaaattac ttagctaatt agtctttctt     8520

tgaagcaatt aactctaacg acattgaggt atgatcattt tcagtattta tgggaggtgg     8580

ctgctgaccc acttgaggtg agatctcaga agcttaactg gcctgaaaat gtaacattct     8640

gccttttact aactccatct tagtttaatc aaagttcaat ctattccttg tttcttctgt     8700

gtgcctcaga gttattttgc atttagttta ctccaccgtg tataatattt atactgtgca     8760

atgttaaaaa agaatctgtt atattgtatg tggtgtacat agtgcaaagt gatgatttct     8820

atttcagggc atattatggt tctcatattc cttcctacct ggtgcacagt agctttttaa     8880

tactagtcac ttctaattta aactttctct tcctgggtca ttgactgtta ctgtgtaata     8940

atcgatttct ttgaaactgc tgcataatta tgctgttagt ggacctctac ctcttctctt     9000

ccctctccca atcacagtat actcagaatc cccagcccct cgcatacatt gtgtcggttc     9060

acattactca cagtaatata tggaagagtt agacaagaac atgcagttac agtcattgtg     9120

agacgtgact ctccagtgtc acgaggaaaa aaatcatctt ttctgcaaac agtctctcat     9180

ctgtcaactc ccacattact gagtcaaaca gtcttcttac ataacaatgc aaccaaatat     9240

atgttgaatt aaagacccat ttataattct gctttaaata catctgcttg ctaagaacag     9300

atttcagtgc tccaagcttc aaatatggag atttgtaaga gggaattcaa tattattcta     9360

atttctctct tacagagtac aaataaaagg tgtatacaaa ctccgaacat atccagtatt     9420

ccaattcctt tgtcaatcag aagagtaaaa taattaacaa aagactgttg ttatggtttg     9480

cattgtaacc gatacgcaga gtctgaccgt tgggcaacaa gtttttctat cctgatgcgc     9540

aacacagtct ctagagacta atccaggaag actttagcct cctttccata ttctcacccc     9600

cgaatcaaga tttacagaag cccacgaaga atttacagcc tgcttgagat catcttgcct     9660

ataaactgag ttattgcttt gtcctaaaaa ttagtcggtt tttttttttc tatgaggctt     9720

ttcagaaatt tacaggatgc ccagacttta catgtgtacc aaaaaaaaaa aaaagataaa     9780

aaataaaggt gcaaagaaag tttagtattt tggaatggtg ctataaagtt gaa            9833


<210> 57
<211> 2289
<212> PRT
<213> Homo sapiens

<400> 57
Met Ala His Asn Ala Gly Ala Ala Ala Ala Ala Gly Thr His Ser Ala 
1               5                   10                  15      


Lys Ser Gly Gly Ser Glu Ala Ala Leu Lys Glu Gly Gly Ser Ala Ala 
            20                  25                  30          


Ala Leu Ser Ser Ser Ser Ser Ser Ser Ala Ala Ala Ala Ala Ala Ser 
        35                  40                  45              


Ser Ser Ser Ser Ser Gly Pro Gly Ser Ala Met Glu Thr Gly Leu Leu 
    50                  55                  60                  


Pro Asn His Lys Leu Lys Thr Val Gly Glu Ala Pro Ala Ala Pro Pro 
65                  70                  75                  80  


His Gln Gln His His His His His His Ala His His His His His His 
                85                  90                  95      


Ala His His Leu His His His His Ala Leu Gln Gln Gln Leu Asn Gln 
            100                 105                 110         


Phe Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
        115                 120                 125             


Gln Gln Gln His Pro Ile Ser Asn Asn Asn Ser Leu Gly Gly Ala Gly 
    130                 135                 140                 


Gly Gly Ala Pro Gln Pro Gly Pro Asp Met Glu Gln Pro Gln His Gly 
145                 150                 155                 160 


Gly Ala Lys Asp Ser Ala Ala Gly Gly Gln Ala Asp Pro Pro Gly Pro 
                165                 170                 175     


Pro Leu Leu Ser Lys Pro Gly Asp Glu Asp Asp Ala Pro Pro Lys Met 
            180                 185                 190         


Gly Glu Pro Ala Gly Gly Arg Tyr Glu His Pro Gly Leu Gly Ala Leu 
        195                 200                 205             


Gly Thr Gln Gln Pro Pro Val Ala Val Pro Gly Gly Gly Gly Gly Pro 
    210                 215                 220                 


Ala Ala Val Pro Glu Phe Asn Asn Tyr Tyr Gly Ser Ala Ala Pro Ala 
225                 230                 235                 240 


Ser Gly Gly Pro Gly Gly Arg Ala Gly Pro Cys Phe Asp Gln His Gly 
                245                 250                 255     


Gly Gln Gln Ser Pro Gly Met Gly Met Met His Ser Ala Ser Ala Ala 
            260                 265                 270         


Ala Ala Gly Ala Pro Gly Ser Met Asp Pro Leu Gln Asn Ser His Glu 
        275                 280                 285             


Gly Tyr Pro Asn Ser Gln Cys Asn His Tyr Pro Gly Tyr Ser Arg Pro 
    290                 295                 300                 


Gly Ala Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Ser 
305                 310                 315                 320 


Gly Gly Gly Gly Gly Gly Gly Gly Ala Gly Ala Gly Gly Ala Gly Ala 
                325                 330                 335     


Gly Ala Val Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Gly Gly 
            340                 345                 350         


Gly Gly Gly Gly Gly Tyr Gly Gly Ser Ser Ala Gly Tyr Gly Val Leu 
        355                 360                 365             


Ser Ser Pro Arg Gln Gln Gly Gly Gly Met Met Met Gly Pro Gly Gly 
    370                 375                 380                 


Gly Gly Ala Ala Ser Leu Ser Lys Ala Ala Ala Gly Ser Ala Ala Gly 
385                 390                 395                 400 


Gly Phe Gln Arg Phe Ala Gly Gln Asn Gln His Pro Ser Gly Ala Thr 
                405                 410                 415     


Pro Thr Leu Asn Gln Leu Leu Thr Ser Pro Ser Pro Met Met Arg Ser 
            420                 425                 430         


Tyr Gly Gly Ser Tyr Pro Glu Tyr Ser Ser Pro Ser Ala Pro Pro Pro 
        435                 440                 445             


Pro Pro Ser Gln Pro Gln Ser Gln Ala Ala Ala Ala Gly Ala Ala Ala 
    450                 455                 460                 


Gly Gly Gln Gln Ala Ala Ala Gly Met Gly Leu Gly Lys Asp Met Gly 
465                 470                 475                 480 


Ala Gln Tyr Ala Ala Ala Ser Pro Ala Trp Ala Ala Ala Gln Gln Arg 
                485                 490                 495     


Ser His Pro Ala Met Ser Pro Gly Thr Pro Gly Pro Thr Met Gly Arg 
            500                 505                 510         


Ser Gln Gly Ser Pro Met Asp Pro Met Val Met Lys Arg Pro Gln Leu 
        515                 520                 525             


Tyr Gly Met Gly Ser Asn Pro His Ser Gln Pro Gln Gln Ser Ser Pro 
    530                 535                 540                 


Tyr Pro Gly Gly Ser Tyr Gly Pro Pro Gly Pro Gln Arg Tyr Pro Ile 
545                 550                 555                 560 


Gly Ile Gln Gly Arg Thr Pro Gly Ala Met Ala Gly Met Gln Tyr Pro 
                565                 570                 575     


Gln Gln Gln Met Pro Pro Gln Tyr Gly Gln Gln Gly Val Ser Gly Tyr 
            580                 585                 590         


Cys Gln Gln Gly Gln Gln Pro Tyr Tyr Ser Gln Gln Pro Gln Pro Pro 
        595                 600                 605             


His Leu Pro Pro Gln Ala Gln Tyr Leu Pro Ser Gln Ser Gln Gln Arg 
    610                 615                 620                 


Tyr Gln Pro Gln Gln Asp Met Ser Gln Glu Gly Tyr Gly Thr Arg Ser 
625                 630                 635                 640 


Gln Pro Pro Leu Ala Pro Gly Lys Pro Asn His Glu Asp Leu Asn Leu 
                645                 650                 655     


Ile Gln Gln Glu Arg Pro Ser Ser Leu Pro Asp Leu Ser Gly Ser Ile 
            660                 665                 670         


Asp Asp Leu Pro Thr Gly Thr Glu Ala Thr Leu Ser Ser Ala Val Ser 
        675                 680                 685             


Ala Ser Gly Ser Thr Ser Ser Gln Gly Asp Gln Ser Asn Pro Ala Gln 
    690                 695                 700                 


Ser Pro Phe Ser Pro His Ala Ser Pro His Leu Ser Ser Ile Pro Gly 
705                 710                 715                 720 


Gly Pro Ser Pro Ser Pro Val Gly Ser Pro Val Gly Ser Asn Gln Ser 
                725                 730                 735     


Arg Ser Gly Pro Ile Ser Pro Ala Ser Ile Pro Gly Ser Gln Met Pro 
            740                 745                 750         


Pro Gln Pro Pro Gly Ser Gln Ser Glu Ser Ser Ser His Pro Ala Leu 
        755                 760                 765             


Ser Gln Ser Pro Met Pro Gln Glu Arg Gly Phe Met Ala Gly Thr Gln 
    770                 775                 780                 


Arg Asn Pro Gln Met Ala Gln Tyr Gly Pro Gln Gln Thr Gly Pro Ser 
785                 790                 795                 800 


Met Ser Pro His Pro Ser Pro Gly Gly Gln Met His Ala Gly Ile Ser 
                805                 810                 815     


Ser Phe Gln Gln Ser Asn Ser Ser Gly Thr Tyr Gly Pro Gln Met Ser 
            820                 825                 830         


Gln Tyr Gly Pro Gln Gly Asn Tyr Ser Arg Pro Pro Ala Tyr Ser Gly 
        835                 840                 845             


Val Pro Ser Ala Ser Tyr Ser Gly Pro Gly Pro Gly Met Gly Ile Ser 
    850                 855                 860                 


Ala Asn Asn Gln Met His Gly Gln Gly Pro Ser Gln Pro Cys Gly Ala 
865                 870                 875                 880 


Val Pro Leu Gly Arg Met Pro Ser Ala Gly Met Gln Asn Arg Pro Phe 
                885                 890                 895     


Pro Gly Asn Met Ser Ser Met Thr Pro Ser Ser Pro Gly Met Ser Gln 
            900                 905                 910         


Gln Gly Gly Pro Gly Met Gly Pro Pro Met Pro Thr Val Asn Arg Lys 
        915                 920                 925             


Ala Gln Glu Ala Ala Ala Ala Val Met Gln Ala Ala Ala Asn Ser Ala 
    930                 935                 940                 


Gln Ser Arg Gln Gly Ser Phe Pro Gly Met Asn Gln Ser Gly Leu Met 
945                 950                 955                 960 


Ala Ser Ser Ser Pro Tyr Ser Gln Pro Met Asn Asn Ser Ser Ser Leu 
                965                 970                 975     


Met Asn Thr Gln Ala Pro Pro Tyr Ser Met Ala Pro Ala Met Val Asn 
            980                 985                 990         


Ser Ser Ala Ala Ser Val Gly Leu  Ala Asp Met Met Ser  Pro Gly Glu 
        995                 1000                 1005             


Ser Lys  Leu Pro Leu Pro Leu  Lys Ala Asp Gly Lys  Glu Glu Gly 
    1010                 1015                 1020             


Thr Pro  Gln Pro Glu Ser Lys  Ser Lys Asp Ser Tyr  Ser Ser Gln 
    1025                 1030                 1035             


Gly Ile  Ser Gln Pro Pro Thr  Pro Gly Asn Leu Pro  Val Pro Ser 
    1040                 1045                 1050             


Pro Met  Ser Pro Ser Ser Ala  Ser Ile Ser Ser Phe  His Gly Asp 
    1055                 1060                 1065             


Glu Ser  Asp Ser Ile Ser Ser  Pro Gly Trp Pro Lys  Thr Pro Ser 
    1070                 1075                 1080             


Ser Pro  Lys Ser Ser Ser Ser  Thr Thr Thr Gly Glu  Lys Ile Thr 
    1085                 1090                 1095             


Lys Val  Tyr Glu Leu Gly Asn  Glu Pro Glu Arg Lys  Leu Trp Val 
    1100                 1105                 1110             


Asp Arg  Tyr Leu Thr Phe Met  Glu Glu Arg Gly Ser  Pro Val Ser 
    1115                 1120                 1125             


Ser Leu  Pro Ala Val Gly Lys  Lys Pro Leu Asp Leu  Phe Arg Leu 
    1130                 1135                 1140             


Tyr Val  Cys Val Lys Glu Ile  Gly Gly Leu Ala Gln  Val Asn Lys 
    1145                 1150                 1155             


Asn Lys  Lys Trp Arg Glu Leu  Ala Thr Asn Leu Asn  Val Gly Thr 
    1160                 1165                 1170             


Ser Ser  Ser Ala Ala Ser Ser  Leu Lys Lys Gln Tyr  Ile Gln Tyr 
    1175                 1180                 1185             


Leu Phe  Ala Phe Glu Cys Lys  Ile Glu Arg Gly Glu  Glu Pro Pro 
    1190                 1195                 1200             


Pro Glu  Val Phe Ser Thr Gly  Asp Thr Lys Lys Gln  Pro Lys Leu 
    1205                 1210                 1215             


Gln Pro  Pro Ser Pro Ala Asn  Ser Gly Ser Leu Gln  Gly Pro Gln 
    1220                 1225                 1230             


Thr Pro  Gln Ser Thr Gly Ser  Asn Ser Met Ala Glu  Val Pro Gly 
    1235                 1240                 1245             


Asp Leu  Lys Pro Pro Thr Pro  Ala Ser Thr Pro His  Gly Gln Met 
    1250                 1255                 1260             


Thr Pro  Met Gln Gly Gly Arg  Ser Ser Thr Ile Ser  Val His Asp 
    1265                 1270                 1275             


Pro Phe  Ser Asp Val Ser Asp  Ser Ser Phe Pro Lys  Arg Asn Ser 
    1280                 1285                 1290             


Met Thr  Pro Asn Ala Pro Tyr  Gln Gln Gly Met Ser  Met Pro Asp 
    1295                 1300                 1305             


Val Met  Gly Arg Met Pro Tyr  Glu Pro Asn Lys Asp  Pro Phe Gly 
    1310                 1315                 1320             


Gly Met  Arg Lys Val Pro Gly  Ser Ser Glu Pro Phe  Met Thr Gln 
    1325                 1330                 1335             


Gly Gln  Met Pro Asn Ser Ser  Met Gln Asp Met Tyr  Asn Gln Ser 
    1340                 1345                 1350             


Pro Ser  Gly Ala Met Ser Asn  Leu Gly Met Gly Gln  Arg Gln Gln 
    1355                 1360                 1365             


Phe Pro  Tyr Gly Ala Ser Tyr  Asp Arg Arg His Glu  Pro Tyr Gly 
    1370                 1375                 1380             


Gln Gln  Tyr Pro Gly Gln Gly  Pro Pro Ser Gly Gln  Pro Pro Tyr 
    1385                 1390                 1395             


Gly Gly  His Gln Pro Gly Leu  Tyr Pro Gln Gln Pro  Asn Tyr Lys 
    1400                 1405                 1410             


Arg His  Met Asp Gly Met Tyr  Gly Pro Pro Ala Lys  Arg His Glu 
    1415                 1420                 1425             


Gly Asp  Met Tyr Asn Met Gln  Tyr Ser Ser Gln Gln  Gln Glu Met 
    1430                 1435                 1440             


Tyr Asn  Gln Tyr Gly Gly Ser  Tyr Ser Gly Pro Asp  Arg Arg Pro 
    1445                 1450                 1455             


Ile Gln  Gly Gln Tyr Pro Tyr  Pro Tyr Ser Arg Glu  Arg Met Gln 
    1460                 1465                 1470             


Gly Pro  Gly Gln Ile Gln Thr  His Gly Ile Pro Pro  Gln Met Met 
    1475                 1480                 1485             


Gly Gly  Pro Leu Gln Ser Ser  Ser Ser Glu Gly Pro  Gln Gln Asn 
    1490                 1495                 1500             


Met Trp  Ala Ala Arg Asn Asp  Met Pro Tyr Pro Tyr  Gln Asn Arg 
    1505                 1510                 1515             


Gln Gly  Pro Gly Gly Pro Thr  Gln Ala Pro Pro Tyr  Pro Gly Met 
    1520                 1525                 1530             


Asn Arg  Thr Asp Asp Met Met  Val Pro Asp Gln Arg  Ile Asn His 
    1535                 1540                 1545             


Glu Ser  Gln Trp Pro Ser His  Val Ser Gln Arg Gln  Pro Tyr Met 
    1550                 1555                 1560             


Ser Ser  Ser Ala Ser Met Gln  Pro Ile Thr Arg Pro  Pro Gln Pro 
    1565                 1570                 1575             


Ser Tyr  Gln Thr Pro Pro Ser  Leu Pro Asn His Ile  Ser Arg Ala 
    1580                 1585                 1590             


Pro Ser  Pro Ala Ser Phe Gln  Arg Ser Leu Glu Asn  Arg Met Ser 
    1595                 1600                 1605             


Pro Ser  Lys Ser Pro Phe Leu  Pro Ser Met Lys Met  Gln Lys Val 
    1610                 1615                 1620             


Met Pro  Thr Val Pro Thr Ser  Gln Val Thr Gly Pro  Pro Pro Gln 
    1625                 1630                 1635             


Pro Pro  Pro Ile Arg Arg Glu  Ile Thr Phe Pro Pro  Gly Ser Val 
    1640                 1645                 1650             


Glu Ala  Ser Gln Pro Val Leu  Lys Gln Arg Arg Lys  Ile Thr Ser 
    1655                 1660                 1665             


Lys Asp  Ile Val Thr Pro Glu  Ala Trp Arg Val Met  Met Ser Leu 
    1670                 1675                 1680             


Lys Ser  Gly Leu Leu Ala Glu  Ser Thr Trp Ala Leu  Asp Thr Ile 
    1685                 1690                 1695             


Asn Ile  Leu Leu Tyr Asp Asp  Ser Thr Val Ala Thr  Phe Asn Leu 
    1700                 1705                 1710             


Ser Gln  Leu Ser Gly Phe Leu  Glu Leu Leu Val Glu  Tyr Phe Arg 
    1715                 1720                 1725             


Lys Cys  Leu Ile Asp Ile Phe  Gly Ile Leu Met Glu  Tyr Glu Val 
    1730                 1735                 1740             


Gly Asp  Pro Ser Gln Lys Ala  Leu Asp His Asn Ala  Ala Arg Lys 
    1745                 1750                 1755             


Asp Asp  Ser Gln Ser Leu Ala  Asp Asp Ser Gly Lys  Glu Glu Glu 
    1760                 1765                 1770             


Asp Ala  Glu Cys Ile Asp Asp  Asp Glu Glu Asp Glu  Glu Asp Glu 
    1775                 1780                 1785             


Glu Glu  Asp Ser Glu Lys Thr  Glu Ser Asp Glu Lys  Ser Ser Ile 
    1790                 1795                 1800             


Ala Leu  Thr Ala Pro Asp Ala  Ala Ala Asp Pro Lys  Glu Lys Pro 
    1805                 1810                 1815             


Lys Gln  Ala Ser Lys Phe Asp  Lys Leu Pro Ile Lys  Ile Val Lys 
    1820                 1825                 1830             


Lys Asn  Asn Leu Phe Val Val  Asp Arg Ser Asp Lys  Leu Gly Arg 
    1835                 1840                 1845             


Val Gln  Glu Phe Asn Ser Gly  Leu Leu His Trp Gln  Leu Gly Gly 
    1850                 1855                 1860             


Gly Asp  Thr Thr Glu His Ile  Gln Thr His Phe Glu  Ser Lys Met 
    1865                 1870                 1875             


Glu Ile  Pro Pro Arg Arg Arg  Pro Pro Pro Pro Leu  Ser Ser Ala 
    1880                 1885                 1890             


Gly Arg  Lys Lys Glu Gln Glu  Gly Lys Gly Asp Ser  Glu Glu Gln 
    1895                 1900                 1905             


Gln Glu  Lys Ser Ile Ile Ala  Thr Ile Asp Asp Val  Leu Ser Ala 
    1910                 1915                 1920             


Arg Pro  Gly Ala Leu Pro Glu  Asp Ala Asn Pro Gly  Pro Gln Thr 
    1925                 1930                 1935             


Glu Ser  Ser Lys Phe Pro Phe  Gly Ile Gln Gln Ala  Lys Ser His 
    1940                 1945                 1950             


Arg Asn  Ile Lys Leu Leu Glu  Asp Glu Pro Arg Ser  Arg Asp Glu 
    1955                 1960                 1965             


Thr Pro  Leu Cys Thr Ile Ala  His Trp Gln Asp Ser  Leu Ala Lys 
    1970                 1975                 1980             


Arg Cys  Ile Cys Val Ser Asn  Ile Val Arg Ser Leu  Ser Phe Val 
    1985                 1990                 1995             


Pro Gly  Asn Asp Ala Glu Met  Ser Lys His Pro Gly  Leu Val Leu 
    2000                 2005                 2010             


Ile Leu  Gly Lys Leu Ile Leu  Leu His His Glu His  Pro Glu Arg 
    2015                 2020                 2025             


Lys Arg  Ala Pro Gln Thr Tyr  Glu Lys Glu Glu Asp  Glu Asp Lys 
    2030                 2035                 2040             


Gly Val  Ala Cys Ser Lys Asp  Glu Trp Trp Trp Asp  Cys Leu Glu 
    2045                 2050                 2055             


Val Leu  Arg Asp Asn Thr Leu  Val Thr Leu Ala Asn  Ile Ser Gly 
    2060                 2065                 2070             


Gln Leu  Asp Leu Ser Ala Tyr  Thr Glu Ser Ile Cys  Leu Pro Ile 
    2075                 2080                 2085             


Leu Asp  Gly Leu Leu His Trp  Met Val Cys Pro Ser  Ala Glu Ala 
    2090                 2095                 2100             


Gln Asp  Pro Phe Pro Thr Val  Gly Pro Asn Ser Val  Leu Ser Pro 
    2105                 2110                 2115             


Gln Arg  Leu Val Leu Glu Thr  Leu Cys Lys Leu Ser  Ile Gln Asp 
    2120                 2125                 2130             


Asn Asn  Val Asp Leu Ile Leu  Ala Thr Pro Pro Phe  Ser Arg Gln 
    2135                 2140                 2145             


Glu Lys  Phe Tyr Ala Thr Leu  Val Arg Tyr Val Gly  Asp Arg Lys 
    2150                 2155                 2160             


Asn Pro  Val Cys Arg Glu Met  Ser Met Ala Leu Leu  Ser Asn Leu 
    2165                 2170                 2175             


Ala Gln  Gly Asp Ala Leu Ala  Ala Arg Ala Ile Ala  Val Gln Lys 
    2180                 2185                 2190             


Gly Ser  Ile Gly Asn Leu Ile  Ser Phe Leu Glu Asp  Gly Val Thr 
    2195                 2200                 2205             


Met Ala  Gln Tyr Gln Gln Ser  Gln His Asn Leu Met  His Met Gln 
    2210                 2215                 2220             


Pro Pro  Pro Leu Glu Pro Pro  Ser Val Asp Met Met  Cys Arg Ala 
    2225                 2230                 2235             


Ala Lys  Ala Leu Leu Ala Met  Ala Arg Val Asp Glu  Asn Arg Ser 
    2240                 2245                 2250             


Glu Phe  Leu Leu His Glu Gly  Arg Leu Leu Asp Ile  Ser Ile Ser 
    2255                 2260                 2265             


Ala Val  Leu Asn Ser Leu Val  Ala Ser Val Ile Cys  Asp Val Leu 
    2270                 2275                 2280             


Phe Gln  Ile Gly Gln Leu 
    2285                 


<210> 58
<211> 11325
<212> DNA
<213> Mus musculus

<400> 58
tcggcgggcc ccggctcgac catggagacc gggctgctcc ccaaccacaa actgaaagcc       60

gttggcgagg cccccgctgc accgccccat cagcagcacc accaccacca tgcccaccac      120

caccaccacc accatgccca ccacctccac cacctccacc accaccacgc actacagcag      180

cagctaaacc agttccagca gccgcagccg ccgcagccac agcagcagca gccgccgcca      240

ccgccgcagc agcagcatcc cactgccaac aacagcctgg gcggtgcggg cggcggcgcg      300

cctcagcccg gcccggacat ggagcagccg caacatggag gcgccaagga cagtgtcgcg      360

ggcaatcagg ctgacccgca gggccagcct ctgctgagca aaccgggcga cgaggacgac      420

gcgccgccca agatggggga gccggcgggc agccgctatg agcacccggg cctgggcgcg      480

cagcagcagc ccgcgccggt cgccgtgccc gggggcggcg gcggcccagc ggccgtctcg      540

gagtttaata attactatgg cagcgctgcc cctgctagcg gcggccccgg cggccgcgct      600

gggccttgct ttgatcaaca tggcggacaa caaagccccg ggatggggat gatgcactcc      660

gcctctgccg ccgccggggc ccccagcagc atggaccccc tgcagaactc ccacgaaggg      720

taccccaaca gccagtacaa ccattatccg ggctacagcc ggcccggcgc gggcggcggc      780

ggcggcggcg gcggaggagg aggaggcagc ggaggaggtg gaggaggagg aggagcagga      840

ggagcaggag gagcagcggc agcggcagca ggagccggag ctgtggcggc ggcggccgcg      900

gcggcggcgg cagcagcagc agcagcagga ggaggcggtg gcggcggcta tgggagctcg      960

tcctcggggt acggggtgct gagctccccg cggcagcagg gcggcggcat gatgatgggc     1020

cccgggggcg gcggggccgc gagcctcagc aaggcggccg ccggcgcggc ggcggcggcg     1080

gggggcttcc agcgcttcgc cggccagaac cagcacccgt cgggggctac accgaccctc     1140

aaccagctgc tcacctcacc cagccccatg atgaggagct acggcggtag ctaccccgac     1200

tacagcagct ccagcgcgcc gccgccgccg tcgcagcccc agtcccaggc ggcggcgggg     1260

gcggcggcgg gtggccagca ggcggccgcg ggcatgggct tgggcaagga cctaggcgcc     1320

cagtacgccg ctgccagccc ggcctgggcg gccgcgcaac aaaggagtca cccggcgatg     1380

agccccggca cccccggacc gaccatgggc agatcccagg gcagcccgat ggacccaatg     1440

gtgatgaaga gacctcagtt gtatgggatg ggtactcacc cccactccca gccacagcag     1500

agcagcccat acccaggagg ctcctacggt cccccaggtg cacagcggta tccccttggc     1560

atgcagggcc gggctccagg ggccctggga ggcttgcagt acccgcagca gcagatgcca     1620

ccgcagtacg gacagcaagc tgtgagtggc tactgccagc aaggccagca gccatactac     1680

aaccagcagc cgcagccctc gcacctcccg ccccaggcac agtacctgca gccggcggcg     1740

gcgcagtccc agcagaggta ccagccacag caggacatgt ctcaagaagg ctatggaact     1800

agatctcagc ctcctctggc ccctggaaaa tccaaccatg aagacttgaa tttaattcaa     1860

caggaaagac catcgagtct accagacctg tctggctcca tcgatgacct ccccacggga     1920

acagaagcaa ctctgagctc agcagtcagt gcatccgggt ctacaagcag ccagggagat     1980

cagagcaacc cagcgcagtc tcctttctcc ccacatgcat cacctcacct ctccagcatc     2040

cctggagggc cgtcaccttc tcctgttggc tctcctgtgg gaagcaacca atcgaggtct     2100

ggtccgatct cccctgcgag tattccaggt agccagatgc ctccgcaacc acctggaagc     2160

cagtcagaat ccagttccca tcctgccttg agccagtcac caatgccaca ggaaagaggt     2220

tttatgacag gcactcagag aaaccctcag atgtctcagt acggacctca gcagacagga     2280

ccatccatgt cgcctcaccc atctcctggg ggccagatgc atcctgggat cagtaacttt     2340

cagcagagta actcaagtgg cacgtacggc ccacagatga gccagtatgg accccaaggc     2400

aactactcca gaaccccaac atatagcggg gtacccagtg caagctacag cggcccaggg     2460

cccggtatgg gcatcaatgc caacaaccag atgcatggac aagggccagc ccagccatgt     2520

ggtgctatgc ccctgggacg aatgccttca gctgggatgc agaacagacc atttcctgga     2580

accatgagca gcgtcacccc cagttctcct ggcatgtctc aacagggagg gccaggaatg     2640

ggcccaccaa tgcccactgt gaaccggaag gcccaggaag ctgccgcagc tgtgatgcag     2700

gctgctgcaa actcagcaca aagcaggcaa ggcagttttc ctggcatgaa ccagagtggc     2760

ctggtggcct ccagctctcc ctacagccag tccatgaaca acaactccag cctgatgagc     2820

acccaggccc agccctacag catgacgccc acaatggtga acagctccac agcatctatg     2880

ggtcttgcag atatgatgtc tcccagtgag tccaaattgt ctgtgcctct taaagcagat     2940

ggtaaagaag aaggcgtgtc ccagcctgag agcaagtcaa aggacagcta tggctctcag     3000

ggcatttccc agcctccaac cccaggcaac ctgcctgtcc cttccccaat gtctcccagc     3060

tctgccagca tctcctcctt tcatggagat gagagtgaca gcattagcag cccaggctgg     3120

cccaagacac catcaagccc taagtccagc tcttcctcca ccactgggga gaagatcacg     3180

aaggtctatg agctggggaa tgagccggag aggaagctgt gggtcgaccg ttacctaacg     3240

ttcatggaag agaggggctc cccggtgtcc agtctgccag cagtgggcaa gaagcccctg     3300

gacctgttcc gactgtatgt ctgcgtcaag gagattggag gtttggcgca ggttaataaa     3360

aacaagaagt ggcgtgagct ggcaaccaac ctgaacgttg gcacttccag cagcgcagcc     3420

agctctctga aaaagcagta tattcagtac ctgttcgcct ttgagtgcaa aactgagcgc     3480

ggggaggagc ccccacctga agtcttcagc accggggatt cgaagaagca gccaaagctc     3540

cagccgccat ctcctgctaa ctcaggatcc ttacaaggcc cacagactcc acagtcaact     3600

gggagcaatt cgatggcaga ggttccaggt gacctgaagc caccaacccc agcctctacc     3660

cctcatggac agatgactcc catgcaaagc ggaagaagca gtacagtcag tgtgcatgac     3720

ccgttctcag acgtgagtga ctcagcgtac ccaaaacgga actccatgac tccaaacgcc     3780

ccataccagc agggcatggg catgccagac atgatgggca ggatgcccta tgaacccaac     3840

aaggaccctt tcagtggaat gagaaaagtg cctggaagta gtgagccctt tatgacacaa     3900

ggacaggtgc ccaacagcgg catgcaggac atgtacaacc agagcccctc aggggccatg     3960

tccaatctgg gcatgggaca gcggcagcag tttccctatg gaaccagtta tgaccgaagg     4020

catgaggctt acggacagca gtacccaggc caaggccctc ccacaggaca gccaccgtat     4080

ggaggacacc agcctggcct gtacccacag cagccgaatt acaaacgtca tatggatggc     4140

atgtacgggc ctccagccaa gcggcacgag ggagacatgt acaacatgca gtatggcagc     4200

cagcagcagg agatgtataa ccagtatgga ggctcctact ctggcccgga cagaaggccc     4260

atccagggac aatatcccta cccctacaac agagaaagga tgcagggccc aggccagatg     4320

cagccacacg gaatcccacc tcagatgatg gggggcccca tgcagtcatc ctccagcgag     4380

gggcctcagc agaacatgtg ggctacacgc aacgatatgc cttatcccta ccagagcagg     4440

caaggcccgg gcggccctgc acaggccccc ccttacccag gcatgaaccg cacagatgat     4500

atgatggtac ctgagcagag gatcaatcac gagagccagt ggccttctca cgtcagccag     4560

cgccagcctt acatgtcatc ttcggcctcc atgcagccca tcacgcgccc acctcagtca     4620

tcctaccaga cgccgccgtc actgccaaac cacatctcca gggcacccag ccccgcctcc     4680

ttccagcgct ccctggagag tcgcatgtct ccaagcaagt ctcccttcct gcccaccatg     4740

aagatgcaga aggtcatgcc cacagtcccc acatcccagg tcaccgggcc ccccccacag     4800

cctccaccaa tcagaaggga gattaccttt cctcctggct ccgtagaagc atcacagcca     4860

atcctgaaac aaaggcgaaa gattacctca aaagatattg ttactcccga ggcgtggcgt     4920

gtgatgatgt cccttaaatc gggtctgttg gctgagagca cgtgggctct ggacaccatc     4980

aatattctcc tctatgatga cagcaccgtc gccaccttca atctttccca gctgtctgga     5040

ttcctggaac tattagtaga gtactttcga aaatgcctaa ttgacatttt cggaattctt     5100

atggaatatg aagtgggtga ccccagccaa aaggctcttg atcaccgttc agggaagaaa     5160

gatgacagcc agtccctgga agatgattct gggaaggaag acgatgatgc tgagtgtctt     5220

gtggaagagg aggaggagga agaggaggag gaggaagaca gtgaaaagat agagtcagag     5280

gggaagagca gccctgccct agctgctcca gatgcctccg tggaccccaa ggagacgcca     5340

aagcaggcca gtaagtttga caagctgccc ataaagattg tcaaaaagaa caagctgttt     5400

gtggtggacc ggtccgacaa gctgggccga gtgcaggagt tcagcagcgg gctcctccac     5460

tggcagctgg gtggtggcga cactaccgag cacatccaga ctcacttcga gagcaagatg     5520

gagatccctc ctcgcaggcg tccacctccg cctctaagct ccacgggtaa gaagaaagag     5580

ctggaaggca aaggtgattc tgaagagcag ccagagaaaa gtatcatagc caccatcgat     5640

gacgtcttgt ctgcccggcc aggggctctg cctgaagaca ccaacccagg accccagacc     5700

gacagcggca agtttccctt tggaatccag caggccaaaa gccaccggaa catcaggctc     5760

ctggaagacg agcccaggag ccgagacgag acgccgctgt gcaccatcgc gcactggcag     5820

gactcactgg ccaagcgctg catctgtgtg tcgaacatcg tgcggagctt gtctttcgtg     5880

cctggcaacg acgcagagat gtccaaacac ccgggcttgg tgctgatcct gggaaagctg     5940

attctgctgc atcacgagca tccggagaga aagcgggcgc cacagaccta tgagaaggag     6000

gaggacgagg acaagggggt ggcctgcagc aaagatgagt ggtggtggga ctgcctcgag     6060

gtcttgcggg ataacaccct ggtcacgttg gcgaacattt ccgggcagct agacttgtct     6120

gcttacacag agagcatctg cttgccgatc ctggacggct tgctacactg gatggtgtgc     6180

ccgtccgcag aggctcagga cccctttccc actgtggggc ccaactcagt cctgtcgccg     6240

cagagacttg tgctggagac cctgtgtaaa ctcagtatcc aggacaacaa cgtggacctg     6300

atcttggcca cgcctccatt tagtcgtcag gagaaatttt atgctacatt agttaggtac     6360

gttggggatc gcaaaaatcc agtctgtcga gaaatgtcca tggcgctttt atcgaacctt     6420

gcccaggggg acacactggc ggcgagggca atagctgtgc agaaaggaag cattggtaac     6480

ttgataagct tcctagagga cggggtgacg atggcgcagt accagcagag ccagcataac     6540

cttatgcaca tgcagccccc acctctggaa ccccctagtg tagacatgat gtgccgggcg     6600

gccaaagctc tgctggccat ggccagagtg gacgagaacc gctcggagtt ccttttgcac     6660

gagggtcggt tgctggatat ctcaatatca gctgtcctga actctctggt tgcatctgtc     6720

atctgtgatg tactgtttca gattgggcag ttatgacatc cgtgaaggca cacatgtgtg     6780

agtgaacatt agagggtcac atataactgg ctgttttctg ttctcgttta tccagtgtaa     6840

gaagaaggaa aagaaaaatc tttgctcctc tgccccgttt actatttacc aattgggaat     6900

taaatcatta atttgaacag ttataaaatt aatatttgct gtctgtgtgt ataagtacat     6960

cctctggcgg ttttctgttt cttttttttt taaccaaagt tgccgtctag tgcattcaaa     7020

ggtcacaatt tttgtttgtt tgtttgtttg tttgtttttt cataattttt ttcatgttgt     7080

attgcagtct ttgggaagtg aattgacttt ataaagaaaa acgttttggc aaaaagtgct     7140

aagatagaaa aatgtcacca cactgggtca aaaacgtgaa aggaaaaatt gattcttaaa     7200

ttgatttcct atgaatttta ttcttcacag aatgataaaa gctaaactgc accccgtcac     7260

ccaaagctct gtgcaataga aacttctaga gatatagtgt aggggctgaa ggaggtatgg     7320

cagcagtagt cagggtcaat gatactgctt tctccaccgg aaagtggtta cgttaggcct     7380

cgagcaaaaa acagcgctct cagataggtg caaaaatcca ctcctagcag ccaacagcag     7440

gatcgcttcc tcaccacgac cgccatgtct gctgtggctc agcctccacg ggacaaagct     7500

tcaagatttc tttcatcatt tttttaaata ttttttttac tgcctatggg ctgtgatgta     7560

tatagaagtt gtacattaaa cataccctca tttttttctt cttttctttt tttctttttt     7620

tctttttctt tttttttttt tttagtacaa agtttttagt ttctttttca tgatgtggta     7680

actacgaagt gatggtagat ttaaataatt ttttattttt attttatata ttttttcatt     7740

aggaccatat ctccaaaaaa caagaaaaag aaacaaaaaa tacaaaaaat aaaaacaaac     7800

aaaaaaagag ggtaatgtac aagtttctgt atgtataaag tcatgctctg ttgggagagc     7860

ggctgatccc agtttgcttc atgaatcaaa gtgtggaaat ggttgcatac agattgattt     7920

agaaaatgga caccagtaca tacaaaaaaa gaaaaaagaa agaaaaccaa ctaaatggaa     7980

gaaacacaac ttcaaagatt tttctgtgac aagaatccac atttgtattt caagataatg     8040

tagtttaaga aaagaaaaaa aagaaaaaaa aagaaaaaaa cttgatgtaa attcctcctt     8100

ttcctctggc ttaatgaata tcatttattc agtataaaat ctttatatgt cccacatgtt     8160

aagaataaat gtacattaaa tcttgttacg cactgtgatg ggtgttcttg aatgctgttc     8220

tagtttgcct agcatggttg ccatagtaac caagttattt acaggaaata gggaagatgt     8280

aacaactgct tcctggtaat gatgcccaaa ggccagaagg gactttcagg gtttcctact     8340

tgagagtggg agcaacaatt tgattttctc agattgttta gctaattagg tcttctttga     8400

agcaattaac tctggtgaca ttgagaagtg gtaattccct catggatggg tggtggctgc     8460

caacccactg tgacatgggg ccctgcaagc taactggcct gaaaccacga ccttctgcct     8520

ctcactactg atttaaccca agtctgcacc cgtcatgttt cttctgtgtg cctccaagtt     8580

actctgcgtt agtttgctcc agcgtgtata atatttatat tgtgcaatgt taaagagaac     8640

gtgtcatatt gtatgccgtg tgtatagtgc caagtgatga ttctgtttca gagcatacct     8700

tccttcctgc ccagtccctg gctctctaat accccaccct gatggaaagt gcttcttcct     8760

gggtaattga ctgttactgt gtaacgctca gtctcattga aacttacata accatgctgc     8820

tggtgcccct tcctacccta cctctctcag cactcttcag ttgacacttc ccacacctgt     8880

cactgtggcc caccttgctc acgctgacat ctggaagagt tagacaggag cacacactta     8940

caacactagg agatgttatt ctggtgtcac gagaaagaaa ttggtttttc ctgcaaacag     9000

tcccatcacc aagcagcccc cacatcaggt cagcaaaaag atctgtgttg aatcaaaact     9060

ccatttataa ttctactaga tgggaataca tctgcttaca aaggacagat tttagtgttc     9120

tgtgatgaaa atatggagag tgcaagagag agttcaatgg aatcctaatc ttgctcttgc     9180

agacaatgaa tgaaaggtat agacaggctc agttccctgt cagaagagtg gtctcaaaga     9240

caagtggctg tatagcagcc aggcccagaa cagcctcgca gcacacacta acaccaagcg     9300

ggtgtctgag ctctcctagg aagccttgtg cctgccctcc ctccattcac ccagatccga     9360

ctcctggaag cccacgaaag agtcaccctt tgcttcacat ttcctgacga taccgagttg     9420

ctgctctgtc ctaaaaatat tagttctttt ccagggcttt cagaaatttg caggatgccc     9480

atactctaaa tgtgtaccaa aaagagagag aaataaaggt gcgaagaaag tttagtattt     9540

tggaatggtg cgataaaatg gaatctgttg gtttttaatg taacataaga tactattggc     9600

tggcactggc taaaaaaaat atctaagtgt tggagttgga tgcacaatca acttttactt     9660

agctattcaa agagtactta tgttttccaa gttaaaacag acttgttttt gacaggggcc     9720

gtgggtggtc ttatacaatg ccagctccta actgcagctt ctgagaactg gatatcgttt     9780

gccctgagag ctgcccgtct ccaactatgt gctgctgctg ccctgtgtgc tcagcccaca     9840

aggatgtgga gactggatag acaacccctt gcttcttgct gggttgtgct gagttctttg     9900

cagtccagtc aagtgcccag agctaccagc ctacgtccct catgcatcca agagaaatga     9960

tcttgactat catgatcaaa acagctgtag taatatttct agtaaatatt tctgatgact    10020

ctgtgtaatc tcctacaaca ggacactatt cattaacttg acagagacat gtgggcatgt    10080

ggtcctgctt tagtttaaca gacaagtcaa ccagttctca ttacttagga agagtgaggc    10140

tatgtctgtt acaatcccaa tgtggtgctt gcccttatcc aaagacagtc cgggggccct    10200

gtctgcctga actatgtctc gctccctctt gggcttccca ctgggatgtg aaaagataac    10260

caatggctcc caggttccca gtgcccccca aaccagtaat caggtctggg actacagaac    10320

ccgcaaaatc atacacaggc tgtttcaaag ccagtactct ctttatactc ctgcttcctc    10380

cagcccccat ttcacacccc acccaaatca caaggtcctc tgaagtctca gaactccaaa    10440

ttaacgttgg gatttacgat gtgaatgctg aggagaaaat tgggagttgg tgggagatca    10500

ccaaattgtc aaaactatga aactcatctg tcttcccaaa tctgacctca gggacttggg    10560

gggttcactc tggcttctgc cacagtattt tctggggaac caaaggcctc gggaatagag    10620

aaacaggttg ccggatatcc tggaagtcta agccatactg accagtttgt cttgagtgtt    10680

ttctttgtga gcctggaact gtccccggac ccctttcttt taaacatggt tcaggacttt    10740

aaaaaaaagc actgtatttt ttttatgtaa gccaagatgc cctccctagc agagatagcg    10800

ttgaactgtc tctagttctg tagcctgaga gacttaaatc gtttaacttc agtgtctttg    10860

tccactctgt tgaactgcta aggattctat tgaatgtgtt ctttgcggct ttggaggagt    10920

tgctgggtgt gtaagtcctg catccctttg cctggtatgt gtatattatt cctttgcctg    10980

gctgtgtatc gttcttcagt gtaagtacac ccacactctg tattcctttg cctgctcccc    11040

gcccccccac acacacacat cctgcatagt tttaaaataa ggcctgagag actgtttcta    11100

tttcctgtca tagctggtga cttttaacag ttgaggcgaa tggcctgtca cttgcctggg    11160

ttcccgtcag gggtgatcca tggaactcct cagtggaaca gaatttagga cagaagatcc    11220

caccttcctt ccaggcctgg ggagaatcag actgtgagat aaaccatgat gctgcccaat    11280

cccactgccc caccttgctt ttaaaataaa gtgcctccta acgtc                    11325


<210> 59
<211> 2244
<212> PRT
<213> Mus musculus

<400> 59
Met Glu Thr Gly Leu Leu Pro Asn His Lys Leu Lys Ala Val Gly Glu 
1               5                   10                  15      


Ala Pro Ala Ala Pro Pro His Gln Gln His His His His His Ala His 
            20                  25                  30          


His His His His His His Ala His His Leu His His Leu His His His 
        35                  40                  45              


His Ala Leu Gln Gln Gln Leu Asn Gln Phe Gln Gln Pro Gln Pro Pro 
    50                  55                  60                  


Gln Pro Gln Gln Gln Gln Pro Pro Pro Pro Pro Gln Gln Gln His Pro 
65                  70                  75                  80  


Thr Ala Asn Asn Ser Leu Gly Gly Ala Gly Gly Gly Ala Pro Gln Pro 
                85                  90                  95      


Gly Pro Asp Met Glu Gln Pro Gln His Gly Gly Ala Lys Asp Ser Val 
            100                 105                 110         


Ala Gly Asn Gln Ala Asp Pro Gln Gly Gln Pro Leu Leu Ser Lys Pro 
        115                 120                 125             


Gly Asp Glu Asp Asp Ala Pro Pro Lys Met Gly Glu Pro Ala Gly Ser 
    130                 135                 140                 


Arg Tyr Glu His Pro Gly Leu Gly Ala Gln Gln Gln Pro Ala Pro Val 
145                 150                 155                 160 


Ala Val Pro Gly Gly Gly Gly Gly Pro Ala Ala Val Ser Glu Phe Asn 
                165                 170                 175     


Asn Tyr Tyr Gly Ser Ala Ala Pro Ala Ser Gly Gly Pro Gly Gly Arg 
            180                 185                 190         


Ala Gly Pro Cys Phe Asp Gln His Gly Gly Gln Gln Ser Pro Gly Met 
        195                 200                 205             


Gly Met Met His Ser Ala Ser Ala Ala Ala Gly Ala Pro Ser Ser Met 
    210                 215                 220                 


Asp Pro Leu Gln Asn Ser His Glu Gly Tyr Pro Asn Ser Gln Tyr Asn 
225                 230                 235                 240 


His Tyr Pro Gly Tyr Ser Arg Pro Gly Ala Gly Gly Gly Gly Gly Gly 
                245                 250                 255     


Gly Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Gly Gly Gly Gly Ala 
            260                 265                 270         


Gly Gly Ala Gly Gly Ala Ala Ala Ala Ala Ala Gly Ala Gly Ala Val 
        275                 280                 285             


Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Gly Gly 
    290                 295                 300                 


Gly Gly Gly Gly Gly Tyr Gly Ser Ser Ser Ser Gly Tyr Gly Val Leu 
305                 310                 315                 320 


Ser Ser Pro Arg Gln Gln Gly Gly Gly Met Met Met Gly Pro Gly Gly 
                325                 330                 335     


Gly Gly Ala Ala Ser Leu Ser Lys Ala Ala Ala Gly Ala Ala Ala Ala 
            340                 345                 350         


Ala Gly Gly Phe Gln Arg Phe Ala Gly Gln Asn Gln His Pro Ser Gly 
        355                 360                 365             


Ala Thr Pro Thr Leu Asn Gln Leu Leu Thr Ser Pro Ser Pro Met Met 
    370                 375                 380                 


Arg Ser Tyr Gly Gly Ser Tyr Pro Asp Tyr Ser Ser Ser Ser Ala Pro 
385                 390                 395                 400 


Pro Pro Pro Ser Gln Pro Gln Ser Gln Ala Ala Ala Gly Ala Ala Ala 
                405                 410                 415     


Gly Gly Gln Gln Ala Ala Ala Gly Met Gly Leu Gly Lys Asp Leu Gly 
            420                 425                 430         


Ala Gln Tyr Ala Ala Ala Ser Pro Ala Trp Ala Ala Ala Gln Gln Arg 
        435                 440                 445             


Ser His Pro Ala Met Ser Pro Gly Thr Pro Gly Pro Thr Met Gly Arg 
    450                 455                 460                 


Ser Gln Gly Ser Pro Met Asp Pro Met Val Met Lys Arg Pro Gln Leu 
465                 470                 475                 480 


Tyr Gly Met Gly Thr His Pro His Ser Gln Pro Gln Gln Ser Ser Pro 
                485                 490                 495     


Tyr Pro Gly Gly Ser Tyr Gly Pro Pro Gly Ala Gln Arg Tyr Pro Leu 
            500                 505                 510         


Gly Met Gln Gly Arg Ala Pro Gly Ala Leu Gly Gly Leu Gln Tyr Pro 
        515                 520                 525             


Gln Gln Gln Met Pro Pro Gln Tyr Gly Gln Gln Ala Val Ser Gly Tyr 
    530                 535                 540                 


Cys Gln Gln Gly Gln Gln Pro Tyr Tyr Asn Gln Gln Pro Gln Pro Ser 
545                 550                 555                 560 


His Leu Pro Pro Gln Ala Gln Tyr Leu Gln Pro Ala Ala Ala Gln Ser 
                565                 570                 575     


Gln Gln Arg Tyr Gln Pro Gln Gln Asp Met Ser Gln Glu Gly Tyr Gly 
            580                 585                 590         


Thr Arg Ser Gln Pro Pro Leu Ala Pro Gly Lys Ser Asn His Glu Asp 
        595                 600                 605             


Leu Asn Leu Ile Gln Gln Glu Arg Pro Ser Ser Leu Pro Asp Leu Ser 
    610                 615                 620                 


Gly Ser Ile Asp Asp Leu Pro Thr Gly Thr Glu Ala Thr Leu Ser Ser 
625                 630                 635                 640 


Ala Val Ser Ala Ser Gly Ser Thr Ser Ser Gln Gly Asp Gln Ser Asn 
                645                 650                 655     


Pro Ala Gln Ser Pro Phe Ser Pro His Ala Ser Pro His Leu Ser Ser 
            660                 665                 670         


Ile Pro Gly Gly Pro Ser Pro Ser Pro Val Gly Ser Pro Val Gly Ser 
        675                 680                 685             


Asn Gln Ser Arg Ser Gly Pro Ile Ser Pro Ala Ser Ile Pro Gly Ser 
    690                 695                 700                 


Gln Met Pro Pro Gln Pro Pro Gly Ser Gln Ser Glu Ser Ser Ser His 
705                 710                 715                 720 


Pro Ala Leu Ser Gln Ser Pro Met Pro Gln Glu Arg Gly Phe Met Thr 
                725                 730                 735     


Gly Thr Gln Arg Asn Pro Gln Met Ser Gln Tyr Gly Pro Gln Gln Thr 
            740                 745                 750         


Gly Pro Ser Met Ser Pro His Pro Ser Pro Gly Gly Gln Met His Pro 
        755                 760                 765             


Gly Ile Ser Asn Phe Gln Gln Ser Asn Ser Ser Gly Thr Tyr Gly Pro 
    770                 775                 780                 


Gln Met Ser Gln Tyr Gly Pro Gln Gly Asn Tyr Ser Arg Thr Pro Thr 
785                 790                 795                 800 


Tyr Ser Gly Val Pro Ser Ala Ser Tyr Ser Gly Pro Gly Pro Gly Met 
                805                 810                 815     


Gly Ile Asn Ala Asn Asn Gln Met His Gly Gln Gly Pro Ala Gln Pro 
            820                 825                 830         


Cys Gly Ala Met Pro Leu Gly Arg Met Pro Ser Ala Gly Met Gln Asn 
        835                 840                 845             


Arg Pro Phe Pro Gly Thr Met Ser Ser Val Thr Pro Ser Ser Pro Gly 
    850                 855                 860                 


Met Ser Gln Gln Gly Gly Pro Gly Met Gly Pro Pro Met Pro Thr Val 
865                 870                 875                 880 


Asn Arg Lys Ala Gln Glu Ala Ala Ala Ala Val Met Gln Ala Ala Ala 
                885                 890                 895     


Asn Ser Ala Gln Ser Arg Gln Gly Ser Phe Pro Gly Met Asn Gln Ser 
            900                 905                 910         


Gly Leu Val Ala Ser Ser Ser Pro Tyr Ser Gln Ser Met Asn Asn Asn 
        915                 920                 925             


Ser Ser Leu Met Ser Thr Gln Ala Gln Pro Tyr Ser Met Thr Pro Thr 
    930                 935                 940                 


Met Val Asn Ser Ser Thr Ala Ser Met Gly Leu Ala Asp Met Met Ser 
945                 950                 955                 960 


Pro Ser Glu Ser Lys Leu Ser Val Pro Leu Lys Ala Asp Gly Lys Glu 
                965                 970                 975     


Glu Gly Val Ser Gln Pro Glu Ser Lys Ser Lys Asp Ser Tyr Gly Ser 
            980                 985                 990         


Gln Gly Ile Ser Gln Pro Pro Thr  Pro Gly Asn Leu Pro  Val Pro Ser 
        995                 1000                 1005             


Pro Met  Ser Pro Ser Ser Ala  Ser Ile Ser Ser Phe  His Gly Asp 
    1010                 1015                 1020             


Glu Ser  Asp Ser Ile Ser Ser  Pro Gly Trp Pro Lys  Thr Pro Ser 
    1025                 1030                 1035             


Ser Pro  Lys Ser Ser Ser Ser  Ser Thr Thr Gly Glu  Lys Ile Thr 
    1040                 1045                 1050             


Lys Val  Tyr Glu Leu Gly Asn  Glu Pro Glu Arg Lys  Leu Trp Val 
    1055                 1060                 1065             


Asp Arg  Tyr Leu Thr Phe Met  Glu Glu Arg Gly Ser  Pro Val Ser 
    1070                 1075                 1080             


Ser Leu  Pro Ala Val Gly Lys  Lys Pro Leu Asp Leu  Phe Arg Leu 
    1085                 1090                 1095             


Tyr Val  Cys Val Lys Glu Ile  Gly Gly Leu Ala Gln  Val Asn Lys 
    1100                 1105                 1110             


Asn Lys  Lys Trp Arg Glu Leu  Ala Thr Asn Leu Asn  Val Gly Thr 
    1115                 1120                 1125             


Ser Ser  Ser Ala Ala Ser Ser  Leu Lys Lys Gln Tyr  Ile Gln Tyr 
    1130                 1135                 1140             


Leu Phe  Ala Phe Glu Cys Lys  Thr Glu Arg Gly Glu  Glu Pro Pro 
    1145                 1150                 1155             


Pro Glu  Val Phe Ser Thr Gly  Asp Ser Lys Lys Gln  Pro Lys Leu 
    1160                 1165                 1170             


Gln Pro  Pro Ser Pro Ala Asn  Ser Gly Ser Leu Gln  Gly Pro Gln 
    1175                 1180                 1185             


Thr Pro  Gln Ser Thr Gly Ser  Asn Ser Met Ala Glu  Val Pro Gly 
    1190                 1195                 1200             


Asp Leu  Lys Pro Pro Thr Pro  Ala Ser Thr Pro His  Gly Gln Met 
    1205                 1210                 1215             


Thr Pro  Met Gln Ser Gly Arg  Ser Ser Thr Val Ser  Val His Asp 
    1220                 1225                 1230             


Pro Phe  Ser Asp Val Ser Asp  Ser Ala Tyr Pro Lys  Arg Asn Ser 
    1235                 1240                 1245             


Met Thr  Pro Asn Ala Pro Tyr  Gln Gln Gly Met Gly  Met Pro Asp 
    1250                 1255                 1260             


Met Met  Gly Arg Met Pro Tyr  Glu Pro Asn Lys Asp  Pro Phe Ser 
    1265                 1270                 1275             


Gly Met  Arg Lys Val Pro Gly  Ser Ser Glu Pro Phe  Met Thr Gln 
    1280                 1285                 1290             


Gly Gln  Val Pro Asn Ser Gly  Met Gln Asp Met Tyr  Asn Gln Ser 
    1295                 1300                 1305             


Pro Ser  Gly Ala Met Ser Asn  Leu Gly Met Gly Gln  Arg Gln Gln 
    1310                 1315                 1320             


Phe Pro  Tyr Gly Thr Ser Tyr  Asp Arg Arg His Glu  Ala Tyr Gly 
    1325                 1330                 1335             


Gln Gln  Tyr Pro Gly Gln Gly  Pro Pro Thr Gly Gln  Pro Pro Tyr 
    1340                 1345                 1350             


Gly Gly  His Gln Pro Gly Leu  Tyr Pro Gln Gln Pro  Asn Tyr Lys 
    1355                 1360                 1365             


Arg His  Met Asp Gly Met Tyr  Gly Pro Pro Ala Lys  Arg His Glu 
    1370                 1375                 1380             


Gly Asp  Met Tyr Asn Met Gln  Tyr Gly Ser Gln Gln  Gln Glu Met 
    1385                 1390                 1395             


Tyr Asn  Gln Tyr Gly Gly Ser  Tyr Ser Gly Pro Asp  Arg Arg Pro 
    1400                 1405                 1410             


Ile Gln  Gly Gln Tyr Pro Tyr  Pro Tyr Asn Arg Glu  Arg Met Gln 
    1415                 1420                 1425             


Gly Pro  Gly Gln Met Gln Pro  His Gly Ile Pro Pro  Gln Met Met 
    1430                 1435                 1440             


Gly Gly  Pro Met Gln Ser Ser  Ser Ser Glu Gly Pro  Gln Gln Asn 
    1445                 1450                 1455             


Met Trp  Ala Thr Arg Asn Asp  Met Pro Tyr Pro Tyr  Gln Ser Arg 
    1460                 1465                 1470             


Gln Gly  Pro Gly Gly Pro Ala  Gln Ala Pro Pro Tyr  Pro Gly Met 
    1475                 1480                 1485             


Asn Arg  Thr Asp Asp Met Met  Val Pro Glu Gln Arg  Ile Asn His 
    1490                 1495                 1500             


Glu Ser  Gln Trp Pro Ser His  Val Ser Gln Arg Gln  Pro Tyr Met 
    1505                 1510                 1515             


Ser Ser  Ser Ala Ser Met Gln  Pro Ile Thr Arg Pro  Pro Gln Ser 
    1520                 1525                 1530             


Ser Tyr  Gln Thr Pro Pro Ser  Leu Pro Asn His Ile  Ser Arg Ala 
    1535                 1540                 1545             


Pro Ser  Pro Ala Ser Phe Gln  Arg Ser Leu Glu Ser  Arg Met Ser 
    1550                 1555                 1560             


Pro Ser  Lys Ser Pro Phe Leu  Pro Thr Met Lys Met  Gln Lys Val 
    1565                 1570                 1575             


Met Pro  Thr Val Pro Thr Ser  Gln Val Thr Gly Pro  Pro Pro Gln 
    1580                 1585                 1590             


Pro Pro  Pro Ile Arg Arg Glu  Ile Thr Phe Pro Pro  Gly Ser Val 
    1595                 1600                 1605             


Glu Ala  Ser Gln Pro Ile Leu  Lys Gln Arg Arg Lys  Ile Thr Ser 
    1610                 1615                 1620             


Lys Asp  Ile Val Thr Pro Glu  Ala Trp Arg Val Met  Met Ser Leu 
    1625                 1630                 1635             


Lys Ser  Gly Leu Leu Ala Glu  Ser Thr Trp Ala Leu  Asp Thr Ile 
    1640                 1645                 1650             


Asn Ile  Leu Leu Tyr Asp Asp  Ser Thr Val Ala Thr  Phe Asn Leu 
    1655                 1660                 1665             


Ser Gln  Leu Ser Gly Phe Leu  Glu Leu Leu Val Glu  Tyr Phe Arg 
    1670                 1675                 1680             


Lys Cys  Leu Ile Asp Ile Phe  Gly Ile Leu Met Glu  Tyr Glu Val 
    1685                 1690                 1695             


Gly Asp  Pro Ser Gln Lys Ala  Leu Asp His Arg Ser  Gly Lys Lys 
    1700                 1705                 1710             


Asp Asp  Ser Gln Ser Leu Glu  Asp Asp Ser Gly Lys  Glu Asp Asp 
    1715                 1720                 1725             


Asp Ala  Glu Cys Leu Val Glu  Glu Glu Glu Glu Glu  Glu Glu Glu 
    1730                 1735                 1740             


Glu Glu  Asp Ser Glu Lys Ile  Glu Ser Glu Gly Lys  Ser Ser Pro 
    1745                 1750                 1755             


Ala Leu  Ala Ala Pro Asp Ala  Ser Val Asp Pro Lys  Glu Thr Pro 
    1760                 1765                 1770             


Lys Gln  Ala Ser Lys Phe Asp  Lys Leu Pro Ile Lys  Ile Val Lys 
    1775                 1780                 1785             


Lys Asn  Lys Leu Phe Val Val  Asp Arg Ser Asp Lys  Leu Gly Arg 
    1790                 1795                 1800             


Val Gln  Glu Phe Ser Ser Gly  Leu Leu His Trp Gln  Leu Gly Gly 
    1805                 1810                 1815             


Gly Asp  Thr Thr Glu His Ile  Gln Thr His Phe Glu  Ser Lys Met 
    1820                 1825                 1830             


Glu Ile  Pro Pro Arg Arg Arg  Pro Pro Pro Pro Leu  Ser Ser Thr 
    1835                 1840                 1845             


Gly Lys  Lys Lys Glu Leu Glu  Gly Lys Gly Asp Ser  Glu Glu Gln 
    1850                 1855                 1860             


Pro Glu  Lys Ser Ile Ile Ala  Thr Ile Asp Asp Val  Leu Ser Ala 
    1865                 1870                 1875             


Arg Pro  Gly Ala Leu Pro Glu  Asp Thr Asn Pro Gly  Pro Gln Thr 
    1880                 1885                 1890             


Asp Ser  Gly Lys Phe Pro Phe  Gly Ile Gln Gln Ala  Lys Ser His 
    1895                 1900                 1905             


Arg Asn  Ile Arg Leu Leu Glu  Asp Glu Pro Arg Ser  Arg Asp Glu 
    1910                 1915                 1920             


Thr Pro  Leu Cys Thr Ile Ala  His Trp Gln Asp Ser  Leu Ala Lys 
    1925                 1930                 1935             


Arg Cys  Ile Cys Val Ser Asn  Ile Val Arg Ser Leu  Ser Phe Val 
    1940                 1945                 1950             


Pro Gly  Asn Asp Ala Glu Met  Ser Lys His Pro Gly  Leu Val Leu 
    1955                 1960                 1965             


Ile Leu  Gly Lys Leu Ile Leu  Leu His His Glu His  Pro Glu Arg 
    1970                 1975                 1980             


Lys Arg  Ala Pro Gln Thr Tyr  Glu Lys Glu Glu Asp  Glu Asp Lys 
    1985                 1990                 1995             


Gly Val  Ala Cys Ser Lys Asp  Glu Trp Trp Trp Asp  Cys Leu Glu 
    2000                 2005                 2010             


Val Leu  Arg Asp Asn Thr Leu  Val Thr Leu Ala Asn  Ile Ser Gly 
    2015                 2020                 2025             


Gln Leu  Asp Leu Ser Ala Tyr  Thr Glu Ser Ile Cys  Leu Pro Ile 
    2030                 2035                 2040             


Leu Asp  Gly Leu Leu His Trp  Met Val Cys Pro Ser  Ala Glu Ala 
    2045                 2050                 2055             


Gln Asp  Pro Phe Pro Thr Val  Gly Pro Asn Ser Val  Leu Ser Pro 
    2060                 2065                 2070             


Gln Arg  Leu Val Leu Glu Thr  Leu Cys Lys Leu Ser  Ile Gln Asp 
    2075                 2080                 2085             


Asn Asn  Val Asp Leu Ile Leu  Ala Thr Pro Pro Phe  Ser Arg Gln 
    2090                 2095                 2100             


Glu Lys  Phe Tyr Ala Thr Leu  Val Arg Tyr Val Gly  Asp Arg Lys 
    2105                 2110                 2115             


Asn Pro  Val Cys Arg Glu Met  Ser Met Ala Leu Leu  Ser Asn Leu 
    2120                 2125                 2130             


Ala Gln  Gly Asp Thr Leu Ala  Ala Arg Ala Ile Ala  Val Gln Lys 
    2135                 2140                 2145             


Gly Ser  Ile Gly Asn Leu Ile  Ser Phe Leu Glu Asp  Gly Val Thr 
    2150                 2155                 2160             


Met Ala  Gln Tyr Gln Gln Ser  Gln His Asn Leu Met  His Met Gln 
    2165                 2170                 2175             


Pro Pro  Pro Leu Glu Pro Pro  Ser Val Asp Met Met  Cys Arg Ala 
    2180                 2185                 2190             


Ala Lys  Ala Leu Leu Ala Met  Ala Arg Val Asp Glu  Asn Arg Ser 
    2195                 2200                 2205             


Glu Phe  Leu Leu His Glu Gly  Arg Leu Leu Asp Ile  Ser Ile Ser 
    2210                 2215                 2220             


Ala Val  Leu Asn Ser Leu Val  Ala Ser Val Ile Cys  Asp Val Leu 
    2225                 2230                 2235             


Phe Gln  Ile Gly Gln Leu 
    2240                 


<210> 60
<211> 5780
<212> DNA
<213> Homo sapiens

<400> 60
ctgggcgggg ccgggaagcg gcagtggcgg ctacgcgcgc gggggtgcgc gcgggaacga       60

ccgggaaaca ccgcgagggc cggggtgggc caggctgtgg ggacgacggg ctgcgacgat      120

ggccgcagcg gcgggcggcg gcgggccggg gacagcggta ggcgccacgg gctcggggat      180

tgcggcggca gccgcaggcc tagctgttta tcgacggaag gatgggggcc cggccaccaa      240

gttttgggag agcccggaga cggtgtccca gctggattcg gtgcgggtct ggctgggcaa      300

gcactacaag aagtatgttc atgcggatgc tcctaccaat aaaacactgg ctgggctggt      360

ggtgcagctt cttcagttcc aggaagatgc ctttgggaag catgtcacca acccggcctt      420

caccaaactc cctgcaaagt gtttcatgga tttcaaagct ggaggcgcct tatgtcacat      480

tcttggggct gcttacaagt ataaaaatga acagggatgg cggaggtttg acctacagaa      540

cccatctcga atggatcgta atgtggaaat gtttatgaac attgaaaaaa cattggtgca      600

gaacaattgt ttgaccagac ccaacatcta cctcattcca gacattgatc tgaagttggc      660

taacaaattg aaagatatca tcaaacgaca tcagggaaca tttacggatg agaagtcaaa      720

agcttcccac cacatttacc catattcttc ctcacaagac gatgaagaat ggttgagacc      780

ggtgatgaga aaagagaagc aagtgttagt gcattggggc ttttacccag acagctatga      840

tacttgggtc catagtaatg atgttgatgc tgaaattgaa gatccaccaa ttccagaaaa      900

accatggaag gttcatgtga aatggatttt ggacactgat attttcaatg aatggatgaa      960

tgaggaggat tatgaggtgg atgaaaatag gaagcctgtg agttttcgtc agcggatttc     1020

aaccaagaat gaagagccag tcagaagtcc agaaagaaga gatagaaaag catcagctaa     1080

tgctcgaaag aggaaacatt cgccttcgcc tccccctccg acaccaacag aatcacggaa     1140

gaagagtggg aagaaaggcc aagctagcct ttatgggaag cgcagaagtc agaaagagga     1200

agatgagcaa gaagatctaa ccaaggatat ggaagaccca acacctgtac ccaatataga     1260

agaagtagta cttcccaaaa atgtgaacct aaagaaagat agtgaaaata cacctgttaa     1320

aggaggaact gtagcggatc tagatgagca ggatgaagaa acagtcacag caggaggaaa     1380

ggaagatgaa gatcctgcca aaggtgatca gagtcgatca gttgaccttg gggaagataa     1440

tgtgacagag cagaccaatc acattattat tcctagttat gcatcatggt ttgattataa     1500

ctgtattcat gtgattgaac ggcgtgctct tcctgagttc ttcaatggaa aaaacaaatc     1560

caagactcca gaaatatact tggcatatcg aaattttatg attgacacgt atcgtctaaa     1620

cccccaagag tatttaacta gcactgcttg tcggaggaac ttgactggag atgtgtgtgc     1680

tgtgatgagg gtccatgcct ttttagagca gtggggactc gttaattacc aagttgaccc     1740

ggaaagtaga cccatggcaa tgggacctcc tcctactcct cattttaatg tattagctga     1800

taccccctct gggcttgtgc ctctgcatct tcgatcacct caggttcctg ctgctcaaca     1860

gatgctaaat tttcctgaga aaaacaagga aaaaccagtt gatttgcaga actttggtct     1920

ccgtactgac atttactcca agaaaacatt agcaaagagt aaaggtgcta gtgctggaag     1980

agaatggact gaacaggaga cccttctact cctggaggcc ctggagatgt acaaggatga     2040

ttggaacaaa gtgtcggaac atgttggaag tcgtactcag gatgaatgca tcctccactt     2100

tttgagactt cccattgagg acccatacct tgagaattca gatgcttccc ttgggccttt     2160

ggcctaccag cctgtcccct tcagtcagtc aggaaatcca gttatgagta ctgttgcttt     2220

tttggcatct gtggtggacc ctcgcgtggc atctgctgca gcaaaagcgg ctttggagga     2280

gttttctcgg gtccgggagg aggtaccact ggaattggtt gaagctcatg tcaagaaagt     2340

acaagaagca gcacgagcct ctgggaaagt ggatcccacc tacggtctgg agagcagctg     2400

cattgcaggc acagggcccg atgagccaga gaagcttgaa ggagctgaag aggaaaaaat     2460

ggaagccgac cctgatggtc agcagcctga aaaggcagaa aataaagtgg aaaatgaaac     2520

ggatgaaggt gataaagcac aagatggaga aaatgaaaaa aatagtgaaa aggaacagga     2580

tagtgaagtg agtgaggata ccaaatcaga agaaaaggag actgaagaga acaaagaact     2640

cactgataca tgtaaagaaa gagaaagtga tactgggaag aagaaagtag aacatgaaat     2700

ttccgaagga aatgttgcca cagccgcagc agctgctctt gcctcagcgg ctaccaaagc     2760

caagcacctg gctgcagtgg aagaaagaaa gatcaagtcc ctggtagctc tcttggttga     2820

gacacaaatg aagaaactag agatcaaact tcgacatttt gaagagctgg aaactatcat     2880

ggacagagag aaagaagctc tagaacaaca gaggcagcag ttgcttactg aacgccaaaa     2940

cttccacatg gaacagctga agtatgctga attacgagca cgacagcaaa tggaacagca     3000

gcagcatggc cagaaccctc aacaggcaca ccagcactca ggaggacctg gcctggcccc     3060

acttggagca gcagggcacc ctggcatgat gcctcatcaa cagccccctc cctaccctct     3120

gatgcaccac cagatgccac cacctcatcc accccagcca ggtcagatac caggcccagg     3180

ttccatgatg cccgggcagc acatgccagg ccgcatgatt cccactgttg cagccaacat     3240

ccacccctct gggagtggcc ctacccctcc tggcatgcca ccaatgccag gaaacatctt     3300

aggaccccgg gtacccctga cagcacctaa cggcatgtat ccccctccac cacagcagca     3360

gccaccgcca ccaccacctg cagatggggt ccctccgcct cctgctcctg gcccgccagc     3420

ctcagctgct ccttagcctg gaagatgcag ggaacctcca cgcccaccac catgagctgg     3480

agtggggatg acaagacttg tgttcctcaa ctttcttggg tttctttcag gatttttctt     3540

ctcacagctc caagcacgtg tcccgtgcct ccccactcct cttaccaccc ctctctctga     3600

cactttttgt gttgggtcct cagccaacac tcaaggggaa acctgtagtg acagtgtgcc     3660

ctggtcatcc ttaaaataac ctgcatctcc cctgtcctgg tgtgggagta agctgacagt     3720

ttctctgcag gtcctgtcaa ctttagcatg ctatgtcttt accatttttg ctctcttgca     3780

gttttttgct ttgtcttatg cttctatgga taatgctata taatcattat ctttttatct     3840

ttctgttatt attgttttaa aggagagcat cctaagttaa taggaaccaa aaaataatga     3900

tgggcagaag ggggggaata gccacagggg acaaacctta aggcattata agtgacctta     3960

tttctgcttt tctgagctaa gaatggtgct gatggtaaag tttgagactt ttgccacaca     4020

caaatttgtg aaaattaaac gagatgtgga aggagaacct cagtgatttt attccctagt     4080

gaggcctctg agggcctcca cactgcctgg cagaacatac cactgaacta gtatgtgcta     4140

gaggagggca caaacatccg ctccttccct aggcctgctg gctctggttt tctatgcaga     4200

tgattcattg gattgggggt gagtgttttg tttttctggg ggcagtgtga gctttgaggg     4260

ttggaatatt gggaggcatt ccttagtttc ctcaactagc ctggaaagtt aggagtctag     4320

ggtaattacc cccaatgagt ctagcctact attcactgct ttgtgtgcat ttttttctcc     4380

ctctttaaaa aaccctttaa aagaaaaaaa aaagtagata gtgctaaata ttttagctca     4440

tgaaacttgg ttaggatggc tgggggtaca agtccccaaa ctacctcttg ttacagtagc     4500

cagggagtgg aatttcgtca accggtactt ttaaggttag gatgggacgg gaaaagtgaa     4560

gcaggatatt agctccttat accttctccc ttccatttct gagatctcac attccatcta     4620

tcacagggtt ttcaaagaga tgctgagggt aacaaggaac tcacttggca gtcagagcat     4680

catgctttga ggtttggggt gctcaggctg ggagggtaga atgccattcc agaggacaag     4740

ccacaaaaat gccttaattt gagctcgtat ttacccctgc tgataagtga cttgagagtt     4800

cccggttttt tcctcttgtc cttccctccc ttctgtcctt ccatgtgtgg ggaaagggtg     4860

tttttggtag agcttggttt ccaaagcgcc tggctttctc acttcacatt ctcaagtggc     4920

agtttcatta tttagaatgc aaggtggaca tcttttggat atctttttct atatattttc     4980

taaagcttta catatgagag ggtataggga ggtgtttata aaacacttga gaactttttt     5040

ccttaatatc agaaagcaaa aaaataaaac cacaattgag atttgccttt caaaccctca     5100

ggtttgcctc taaccaggtg tccctggtca ccatcagagt actggaatac gggaaccgag     5160

gagaccttgg tccttttgtt tttgttctgg actcttggga gtggaaatga gaatgagttt     5220

attcctactg gagcttagtt ccaatgcatt tggctccaga aagaccccag tgccttttga     5280

caatggccag ggttttacct acttcctgcc agtctttccc aaaggaaact cattccaaat     5340

acttcttttt tcccctggag tccgagaagg aaaatggaat tctggttcat actgtggtcc     5400

cttgtaacct caggtcttta atgtgatcac tttcaaattt aaaagatcca ggtggaaata     5460

tttttactat agtaataatt ctacaaaata cctgaattct taacactgtt atatttcagt     5520

ataagtggtg gctttttctt ttcatgtctt tgatctggtt ttattcctgt aattcagcca     5580

cctgattttg tgaggggggg gaataatatg tggtttttgt acaaacatgt ttctcagtgt     5640

gttgttattt tggaaaaaat gaggggaggg agtttggcaa gaatggagaa aatgaatgaa     5700

gaaggcctaa tctctctctt tttcagtgaa taaatggaac accatttctg gattctaaaa     5760

aaaaaaaaaa aaaaaaaaaa                                                 5780


<210> 61
<211> 1104
<212> PRT
<213> Homo sapiens

<400> 61
Met Ala Ala Ala Ala Gly Gly Gly Gly Pro Gly Thr Ala Val Gly Ala 
1               5                   10                  15      


Thr Gly Ser Gly Ile Ala Ala Ala Ala Ala Gly Leu Ala Val Tyr Arg 
            20                  25                  30          


Arg Lys Asp Gly Gly Pro Ala Thr Lys Phe Trp Glu Ser Pro Glu Thr 
        35                  40                  45              


Val Ser Gln Leu Asp Ser Val Arg Val Trp Leu Gly Lys His Tyr Lys 
    50                  55                  60                  


Lys Tyr Val His Ala Asp Ala Pro Thr Asn Lys Thr Leu Ala Gly Leu 
65                  70                  75                  80  


Val Val Gln Leu Leu Gln Phe Gln Glu Asp Ala Phe Gly Lys His Val 
                85                  90                  95      


Thr Asn Pro Ala Phe Thr Lys Leu Pro Ala Lys Cys Phe Met Asp Phe 
            100                 105                 110         


Lys Ala Gly Gly Ala Leu Cys His Ile Leu Gly Ala Ala Tyr Lys Tyr 
        115                 120                 125             


Lys Asn Glu Gln Gly Trp Arg Arg Phe Asp Leu Gln Asn Pro Ser Arg 
    130                 135                 140                 


Met Asp Arg Asn Val Glu Met Phe Met Asn Ile Glu Lys Thr Leu Val 
145                 150                 155                 160 


Gln Asn Asn Cys Leu Thr Arg Pro Asn Ile Tyr Leu Ile Pro Asp Ile 
                165                 170                 175     


Asp Leu Lys Leu Ala Asn Lys Leu Lys Asp Ile Ile Lys Arg His Gln 
            180                 185                 190         


Gly Thr Phe Thr Asp Glu Lys Ser Lys Ala Ser His His Ile Tyr Pro 
        195                 200                 205             


Tyr Ser Ser Ser Gln Asp Asp Glu Glu Trp Leu Arg Pro Val Met Arg 
    210                 215                 220                 


Lys Glu Lys Gln Val Leu Val His Trp Gly Phe Tyr Pro Asp Ser Tyr 
225                 230                 235                 240 


Asp Thr Trp Val His Ser Asn Asp Val Asp Ala Glu Ile Glu Asp Pro 
                245                 250                 255     


Pro Ile Pro Glu Lys Pro Trp Lys Val His Val Lys Trp Ile Leu Asp 
            260                 265                 270         


Thr Asp Ile Phe Asn Glu Trp Met Asn Glu Glu Asp Tyr Glu Val Asp 
        275                 280                 285             


Glu Asn Arg Lys Pro Val Ser Phe Arg Gln Arg Ile Ser Thr Lys Asn 
    290                 295                 300                 


Glu Glu Pro Val Arg Ser Pro Glu Arg Arg Asp Arg Lys Ala Ser Ala 
305                 310                 315                 320 


Asn Ala Arg Lys Arg Lys His Ser Pro Ser Pro Pro Pro Pro Thr Pro 
                325                 330                 335     


Thr Glu Ser Arg Lys Lys Ser Gly Lys Lys Gly Gln Ala Ser Leu Tyr 
            340                 345                 350         


Gly Lys Arg Arg Ser Gln Lys Glu Glu Asp Glu Gln Glu Asp Leu Thr 
        355                 360                 365             


Lys Asp Met Glu Asp Pro Thr Pro Val Pro Asn Ile Glu Glu Val Val 
    370                 375                 380                 


Leu Pro Lys Asn Val Asn Leu Lys Lys Asp Ser Glu Asn Thr Pro Val 
385                 390                 395                 400 


Lys Gly Gly Thr Val Ala Asp Leu Asp Glu Gln Asp Glu Glu Thr Val 
                405                 410                 415     


Thr Ala Gly Gly Lys Glu Asp Glu Asp Pro Ala Lys Gly Asp Gln Ser 
            420                 425                 430         


Arg Ser Val Asp Leu Gly Glu Asp Asn Val Thr Glu Gln Thr Asn His 
        435                 440                 445             


Ile Ile Ile Pro Ser Tyr Ala Ser Trp Phe Asp Tyr Asn Cys Ile His 
    450                 455                 460                 


Val Ile Glu Arg Arg Ala Leu Pro Glu Phe Phe Asn Gly Lys Asn Lys 
465                 470                 475                 480 


Ser Lys Thr Pro Glu Ile Tyr Leu Ala Tyr Arg Asn Phe Met Ile Asp 
                485                 490                 495     


Thr Tyr Arg Leu Asn Pro Gln Glu Tyr Leu Thr Ser Thr Ala Cys Arg 
            500                 505                 510         


Arg Asn Leu Thr Gly Asp Val Cys Ala Val Met Arg Val His Ala Phe 
        515                 520                 525             


Leu Glu Gln Trp Gly Leu Val Asn Tyr Gln Val Asp Pro Glu Ser Arg 
    530                 535                 540                 


Pro Met Ala Met Gly Pro Pro Pro Thr Pro His Phe Asn Val Leu Ala 
545                 550                 555                 560 


Asp Thr Pro Ser Gly Leu Val Pro Leu His Leu Arg Ser Pro Gln Val 
                565                 570                 575     


Pro Ala Ala Gln Gln Met Leu Asn Phe Pro Glu Lys Asn Lys Glu Lys 
            580                 585                 590         


Pro Val Asp Leu Gln Asn Phe Gly Leu Arg Thr Asp Ile Tyr Ser Lys 
        595                 600                 605             


Lys Thr Leu Ala Lys Ser Lys Gly Ala Ser Ala Gly Arg Glu Trp Thr 
    610                 615                 620                 


Glu Gln Glu Thr Leu Leu Leu Leu Glu Ala Leu Glu Met Tyr Lys Asp 
625                 630                 635                 640 


Asp Trp Asn Lys Val Ser Glu His Val Gly Ser Arg Thr Gln Asp Glu 
                645                 650                 655     


Cys Ile Leu His Phe Leu Arg Leu Pro Ile Glu Asp Pro Tyr Leu Glu 
            660                 665                 670         


Asn Ser Asp Ala Ser Leu Gly Pro Leu Ala Tyr Gln Pro Val Pro Phe 
        675                 680                 685             


Ser Gln Ser Gly Asn Pro Val Met Ser Thr Val Ala Phe Leu Ala Ser 
    690                 695                 700                 


Val Val Asp Pro Arg Val Ala Ser Ala Ala Ala Lys Ala Ala Leu Glu 
705                 710                 715                 720 


Glu Phe Ser Arg Val Arg Glu Glu Val Pro Leu Glu Leu Val Glu Ala 
                725                 730                 735     


His Val Lys Lys Val Gln Glu Ala Ala Arg Ala Ser Gly Lys Val Asp 
            740                 745                 750         


Pro Thr Tyr Gly Leu Glu Ser Ser Cys Ile Ala Gly Thr Gly Pro Asp 
        755                 760                 765             


Glu Pro Glu Lys Leu Glu Gly Ala Glu Glu Glu Lys Met Glu Ala Asp 
    770                 775                 780                 


Pro Asp Gly Gln Gln Pro Glu Lys Ala Glu Asn Lys Val Glu Asn Glu 
785                 790                 795                 800 


Thr Asp Glu Gly Asp Lys Ala Gln Asp Gly Glu Asn Glu Lys Asn Ser 
                805                 810                 815     


Glu Lys Glu Gln Asp Ser Glu Val Ser Glu Asp Thr Lys Ser Glu Glu 
            820                 825                 830         


Lys Glu Thr Glu Glu Asn Lys Glu Leu Thr Asp Thr Cys Lys Glu Arg 
        835                 840                 845             


Glu Ser Asp Thr Gly Lys Lys Lys Val Glu His Glu Ile Ser Glu Gly 
    850                 855                 860                 


Asn Val Ala Thr Ala Ala Ala Ala Ala Leu Ala Ser Ala Ala Thr Lys 
865                 870                 875                 880 


Ala Lys His Leu Ala Ala Val Glu Glu Arg Lys Ile Lys Ser Leu Val 
                885                 890                 895     


Ala Leu Leu Val Glu Thr Gln Met Lys Lys Leu Glu Ile Lys Leu Arg 
            900                 905                 910         


His Phe Glu Glu Leu Glu Thr Ile Met Asp Arg Glu Lys Glu Ala Leu 
        915                 920                 925             


Glu Gln Gln Arg Gln Gln Leu Leu Thr Glu Arg Gln Asn Phe His Met 
    930                 935                 940                 


Glu Gln Leu Lys Tyr Ala Glu Leu Arg Ala Arg Gln Gln Met Glu Gln 
945                 950                 955                 960 


Gln Gln His Gly Gln Asn Pro Gln Gln Ala His Gln His Ser Gly Gly 
                965                 970                 975     


Pro Gly Leu Ala Pro Leu Gly Ala Ala Gly His Pro Gly Met Met Pro 
            980                 985                 990         


His Gln Gln Pro Pro Pro Tyr Pro  Leu Met His His Gln  Met Pro Pro 
        995                 1000                 1005             


Pro His  Pro Pro Gln Pro Gly  Gln Ile Pro Gly Pro  Gly Ser Met 
    1010                 1015                 1020             


Met Pro  Gly Gln His Met Pro  Gly Arg Met Ile Pro  Thr Val Ala 
    1025                 1030                 1035             


Ala Asn  Ile His Pro Ser Gly  Ser Gly Pro Thr Pro  Pro Gly Met 
    1040                 1045                 1050             


Pro Pro  Met Pro Gly Asn Ile  Leu Gly Pro Arg Val  Pro Leu Thr 
    1055                 1060                 1065             


Ala Pro  Asn Gly Met Tyr Pro  Pro Pro Pro Gln Gln  Gln Pro Pro 
    1070                 1075                 1080             


Pro Pro  Pro Pro Ala Asp Gly  Val Pro Pro Pro Pro  Ala Pro Gly 
    1085                 1090                 1095             


Pro Pro  Ala Ser Ala Pro 
    1100                 


<210> 62
<211> 5684
<212> DNA
<213> Mus musculus

<400> 62
ggaggtggca tctgcgcgcg cgcgcgcggg tgcgaacggg aaacgccgcg agggccaggc       60

taggccgggc ggtagacacg acggacggtg actatggccg cgacagcggg tggcggtccg      120

ggagcagcag caggcgccgt gggtgcaggg ggtgcggcgg cggcctccgg gctggccgtg      180

taccggagga aggacggggg cccggccagc aagttttggg agagcccgga cacggtgtcc      240

cagctagatt cggtgcgagt ctggctgggc aagcactaca agaagtatgt tcatgcagat      300

gctcctacca ataaaacact agctggactg gtggtgcagc ttctacagtt ccaagaagat      360

gcctttggga agcatgtcac caacccagct ttcaccaaac tacctgcaaa atgtttcatg      420

gatttcaaag ctggaggcac cttgtgtcac attcttgggg cagcttacaa gtacaaaaat      480

gaacagggct ggcggagatt tgatcttcag aacccatccc gaatggatcg taacgttgaa      540

atgttcatga acattgagaa aacattggta cagaacaact gtctgactag accaaacatc      600

tacctcattc cagacattga tttgaagttg gctaacaagt tgaaagatat catcaaacgg      660

catcagggga catttactga tgagaagtca aaagcttccc accatattta tccatatcct      720

tcctcacaag aggatgagga gtggctgaga ccagtgatga ggagagacaa gcaggtgctg      780

gtgcactggg gtttctaccc agacagctat gacacttggg tccacagtaa tgatgttgat      840

gctgaaattg aagatgcacc aatcccagaa aagccctgga aggttcatgt aaaatggatt      900

ttggacactg acgttttcaa tgaatggatg aatgaagagg attatgaagt ggatgagaac      960

agaaagccag tgagctttcg tcaacgaatt tcaacaaaga atgaagagcc agtcagaagt     1020

ccagaaagga gagacagaaa agcctctgcc aactctagga agaggaaacc ttccccttct     1080

cctcctcctc ccacagccac agagtcccgc aagaagagcg ggaagaaagg acaagctagc     1140

ctttatggga aacgtagaag tcagaaggaa gaagatgagc aagaagatct taccaaggac     1200

atggaagacc ccacacctgt acctaacata gaggaagtgg ttctccctaa gaatgtaaac     1260

ccaaagaagg acagtgaaaa cacacccgtt aaaggaggca cggtggcaga tctagatgag     1320

caggatgaag aagcagttac aacaggagga aaggaagatg aagatcccag caaaggtgat     1380

ccaagtcgct cagttgaccc aggtgaagac aacgtgacag aacagaccaa tcacatcatt     1440

attcccagct acgcatcctg gtttgattat aattgtattc atgtcattga acggcgtgcg     1500

cttcctgagt tctttaatgg aaaaaacaaa tccaagaccc ctgaaatata cttggcatat     1560

cgaaatttta tgattgacac ataccgtcta aaccctcaag aatatttaac cagcactgct     1620

tgccggcgaa acctgactgg agatgtgtgt gctgtgatga gggttcatgc cttcttagag     1680

cagtggggtc ttgttaacta ccaagttgac ccagagagtc gacccatggc aatgggacct     1740

cctcccactc ctcacttcaa tgtgttagct gacacaccct ctgggcttgt gcccctgcat     1800

cttcgatcac ctcaggtccc tgccgctcaa cagatgttaa attttcctga gaagaacaag     1860

gaaaaaccaa ttgatttgca gaactttggt cttcgaactg acatttactc caagaaaaca     1920

ctggcaaaga gtaaaggtgc tagtgctgga agggagtgga cagaacagga gacccttctt     1980

ctcctagagg ctctggagat gtacaaggac gattggaata aagtgtcaga acatgttgga     2040

agccgtactc aggacgaatg catcctccac tttctgaggc ttcccattga ggacccttac     2100

cttgaaaatt cagatgcttc tcttgggcca ctggcttacc agcctgtccc tttcagccag     2160

tcgggaaacc cggtgatgag cactgttgcc tttttagcat ctgtcgttga cccccgtgta     2220

gcatctgctg cagcaaaagc agcgttggag gagttttctc gtgtccgaga agaagtaccc     2280

ctggaattgg ttgaagcaca tgtcaagaaa gtacaggaag ctgcaagagc ctctgggaag     2340

gtggacccca cctatggctt ggagagcagc tgtattgctg gcacagggcc tgacgagcca     2400

gagaagcttg aaggatctga agaagagaag atggaaacag atcctgatgg tcagcagcct     2460

gaaaaggcag aaaacaaagt ggaaaatgaa tcggatgaag gtgataaaat acaagatcga     2520

gagaatgaaa aaaacactga gaaggaacaa gatagtgacg tcagtgagga tgtcaagcca     2580

gaagaaaagg agaatgaaga gaacaaagag ctcactgata catgtaaaga aagagaaagc     2640

gatgccggga agaagaaagt ggaacacgag atttcggaag gaaacgttgc cacagccgca     2700

gcagctgctc tggcctcagc tgctactaaa gccaagcacc tggcggctgt tgaagaaaga     2760

aaaatcaagt ccttggtagc tctcttggtt gaaacacaaa tgaagaaact agagatcaaa     2820

cttcgacatt ttgaagagct ggagactata atggacagag agaaagaggc tctagaacaa     2880

cagagacagc agttgcttac tgagcgtcag aacttccaca tggaacagtt gaaatatgct     2940

gaactacgtg cccggcagca aatggagcag cagcagcagc atggccagac acctcagcag     3000

gcgcaccagc acacgggagg gccggggatg gccccacttg gagccacagg ccaccctggc     3060

atgatgccgc atcagcagcc ccctccctac ccactgatgc accatcagat gccgccaccc     3120

catcctcccc aaccaggtca aataccaggc cctggctcca tgatgcctgg ccagcccatg     3180

ccaggtcgca tgatccccgc tgtggcagcc aacattcacc ctactgggag tggccctacc     3240

cctcctggta tgcctccaat gcccggaaac atcttaggac cccgggtacc cctcacagca     3300

ccaaacggca tgtatcctcc tccaccacag cagcagcagc cgcctcctcc tgcagatggg     3360

gtccctccac ctcctgctcc aggcccaccc gcctcggcca ctccctagcc tggaagatac     3420

aagagcctcc acagccacca caagcaggaa tggggatggc aggacttgtg tctcggcttc     3480

cttggttttc ttgcaggatt tttttttcac aaccccaagc acaagcccca tgtctctcca     3540

ctccttgata cttcttgtgt caggtcctta gttgacactc attgggaagc ctgtggtgac     3600

tgatgtgctc tggtcattta aaaagtacca tgtgtctccc ctgtccccgt gtgacagatg     3660

ttggcaggtg gtctgcaggt cctgttgtgt tgacattagt attctttgtg tgtatctctc     3720

tctgtctctc tctctctgct ttgtctaagg cttcaatgta taatcctcta taattattgt     3780

cctttcttcc tttgtaatgg ttgttttttt aaggaaagta tcctaagtta atagaaacca     3840

aaaaaaatgg taatgggcag aaagagatag ccacagaggg acacacctta aggcattata     3900

agtgacctta tttctgctta tctgagctag agtggtgcta ctgatagagt ccctgagact     3960

tgtcacacat aagtgcacca agatgagaag agctggggaa agggggtatc ctttcgattt     4020

gatttcctgg tgaggaccat gaaggacttc cctgtgcctg gaagaacatg ccactgtacc     4080

tagtacacga tagatagcaa agagcacagc tttacaacaa gcccttccta ccttctcccg     4140

ccattctggt tgtctgtgca gaagatttgc aggattggaa catggtggtt gttttcccaa     4200

gggcagcgtg agctttcaga gttggggttt tcccagtcta acaaagataa agggtctggg     4260

gccctaccta caaaccttta ggaacccttc caaacctccc aaccttcccc aaacacatag     4320

ggcctaccct cgccacccca ataaacatta catgtttttt aaaccttcct ataagaaagg     4380

aaaaaaatgt aaaatgggtt atagattatg ttgaacattt tatctcatgc ggcttggtgg     4440

gggtgggggt acagatccct aaactacctc ttgctgtagc cagggtgagc ggggttctta     4500

agcggtactg aggtgcagaa cgggagtggg aatgctcaca tgtgatgagc agcctcctgt     4560

acctcacatt ctgagacctc acattccatc tgttgtcaca gggttatgga gactgtgcta     4620

atggcacaag gacctcactt ggctccagag tgcgaggctg taaggtttaa gtgccatccc     4680

agaggaattg ccaccaaaaa aaaaaaaaaa agccttaatc tgagcctgta tctacccctg     4740

ctgatgaaca actagatggg ttttggtttt gccagcttct ttcctccctc cctccctccc     4800

tccctccctc cctccctcct ttctgtcttt ccattagtag caaaagggtg tttttagcag     4860

aactttaagt ggcagtttca ttcttgagag tgcaaggtag agcaccttac gggtgtattt     4920

ttatgtgtat tttaaagctt tatgtatgag agctataggt aggcatttct taataacaca     4980

aaaacctaca gttgagattt gcctttaaga ctcttggttt tcctctaacc aggagcccac     5040

gtcaccgcca gagtcctgga gctagagcta atgactccag agccttgggg tggaaatgga     5100

gattcgctta ttccctgggt gcttgttttt cctccaggaa aaccccggtg tcttctgacc     5160

gcagccaggg ttgccctcct tccctccatt ctctcccaaa gtaaattgac tccagcactt     5220

gccttctccc cggagtccta ggggaggtat aggactctgc ttgtctgtaa cctgaggtct     5280

gtaatgtgat tgctttccag ttttgagaga tgcaagtggg aatagttttt acattgttga     5340

taatctatag aacctaagtt caacacttca acacagctct ttccatgact gtcagttagg     5400

tatcattcct gtaataacac ccatccagtt ttgtgagggg cgggcttgga tactgtgtgg     5460

tttttgtaca aatgtgtttc tcagtgtggg tttttgtttt ttgttgggtt tttttttttt     5520

ttttggtgtt tttttgtttg tttatttgtt ttttttcttt aggttttgtt ctaatgaggt     5580

aaaggagctt tgagagtttg ggagaaaatg aatgaaagtg gcttaatgtc cctcgtttgc     5640

attgaataaa tgaaatacca tttatgaatt ctaaaaaaaa aaaa                      5684


<210> 63
<211> 1104
<212> PRT
<213> Mus musculus

<400> 63
Met Ala Ala Thr Ala Gly Gly Gly Pro Gly Ala Ala Ala Gly Ala Val 
1               5                   10                  15      


Gly Ala Gly Gly Ala Ala Ala Ala Ser Gly Leu Ala Val Tyr Arg Arg 
            20                  25                  30          


Lys Asp Gly Gly Pro Ala Ser Lys Phe Trp Glu Ser Pro Asp Thr Val 
        35                  40                  45              


Ser Gln Leu Asp Ser Val Arg Val Trp Leu Gly Lys His Tyr Lys Lys 
    50                  55                  60                  


Tyr Val His Ala Asp Ala Pro Thr Asn Lys Thr Leu Ala Gly Leu Val 
65                  70                  75                  80  


Val Gln Leu Leu Gln Phe Gln Glu Asp Ala Phe Gly Lys His Val Thr 
                85                  90                  95      


Asn Pro Ala Phe Thr Lys Leu Pro Ala Lys Cys Phe Met Asp Phe Lys 
            100                 105                 110         


Ala Gly Gly Thr Leu Cys His Ile Leu Gly Ala Ala Tyr Lys Tyr Lys 
        115                 120                 125             


Asn Glu Gln Gly Trp Arg Arg Phe Asp Leu Gln Asn Pro Ser Arg Met 
    130                 135                 140                 


Asp Arg Asn Val Glu Met Phe Met Asn Ile Glu Lys Thr Leu Val Gln 
145                 150                 155                 160 


Asn Asn Cys Leu Thr Arg Pro Asn Ile Tyr Leu Ile Pro Asp Ile Asp 
                165                 170                 175     


Leu Lys Leu Ala Asn Lys Leu Lys Asp Ile Ile Lys Arg His Gln Gly 
            180                 185                 190         


Thr Phe Thr Asp Glu Lys Ser Lys Ala Ser His His Ile Tyr Pro Tyr 
        195                 200                 205             


Pro Ser Ser Gln Glu Asp Glu Glu Trp Leu Arg Pro Val Met Arg Arg 
    210                 215                 220                 


Asp Lys Gln Val Leu Val His Trp Gly Phe Tyr Pro Asp Ser Tyr Asp 
225                 230                 235                 240 


Thr Trp Val His Ser Asn Asp Val Asp Ala Glu Ile Glu Asp Ala Pro 
                245                 250                 255     


Ile Pro Glu Lys Pro Trp Lys Val His Val Lys Trp Ile Leu Asp Thr 
            260                 265                 270         


Asp Val Phe Asn Glu Trp Met Asn Glu Glu Asp Tyr Glu Val Asp Glu 
        275                 280                 285             


Asn Arg Lys Pro Val Ser Phe Arg Gln Arg Ile Ser Thr Lys Asn Glu 
    290                 295                 300                 


Glu Pro Val Arg Ser Pro Glu Arg Arg Asp Arg Lys Ala Ser Ala Asn 
305                 310                 315                 320 


Ser Arg Lys Arg Lys Pro Ser Pro Ser Pro Pro Pro Pro Thr Ala Thr 
                325                 330                 335     


Glu Ser Arg Lys Lys Ser Gly Lys Lys Gly Gln Ala Ser Leu Tyr Gly 
            340                 345                 350         


Lys Arg Arg Ser Gln Lys Glu Glu Asp Glu Gln Glu Asp Leu Thr Lys 
        355                 360                 365             


Asp Met Glu Asp Pro Thr Pro Val Pro Asn Ile Glu Glu Val Val Leu 
    370                 375                 380                 


Pro Lys Asn Val Asn Pro Lys Lys Asp Ser Glu Asn Thr Pro Val Lys 
385                 390                 395                 400 


Gly Gly Thr Val Ala Asp Leu Asp Glu Gln Asp Glu Glu Ala Val Thr 
                405                 410                 415     


Thr Gly Gly Lys Glu Asp Glu Asp Pro Ser Lys Gly Asp Pro Ser Arg 
            420                 425                 430         


Ser Val Asp Pro Gly Glu Asp Asn Val Thr Glu Gln Thr Asn His Ile 
        435                 440                 445             


Ile Ile Pro Ser Tyr Ala Ser Trp Phe Asp Tyr Asn Cys Ile His Val 
    450                 455                 460                 


Ile Glu Arg Arg Ala Leu Pro Glu Phe Phe Asn Gly Lys Asn Lys Ser 
465                 470                 475                 480 


Lys Thr Pro Glu Ile Tyr Leu Ala Tyr Arg Asn Phe Met Ile Asp Thr 
                485                 490                 495     


Tyr Arg Leu Asn Pro Gln Glu Tyr Leu Thr Ser Thr Ala Cys Arg Arg 
            500                 505                 510         


Asn Leu Thr Gly Asp Val Cys Ala Val Met Arg Val His Ala Phe Leu 
        515                 520                 525             


Glu Gln Trp Gly Leu Val Asn Tyr Gln Val Asp Pro Glu Ser Arg Pro 
    530                 535                 540                 


Met Ala Met Gly Pro Pro Pro Thr Pro His Phe Asn Val Leu Ala Asp 
545                 550                 555                 560 


Thr Pro Ser Gly Leu Val Pro Leu His Leu Arg Ser Pro Gln Val Pro 
                565                 570                 575     


Ala Ala Gln Gln Met Leu Asn Phe Pro Glu Lys Asn Lys Glu Lys Pro 
            580                 585                 590         


Ile Asp Leu Gln Asn Phe Gly Leu Arg Thr Asp Ile Tyr Ser Lys Lys 
        595                 600                 605             


Thr Leu Ala Lys Ser Lys Gly Ala Ser Ala Gly Arg Glu Trp Thr Glu 
    610                 615                 620                 


Gln Glu Thr Leu Leu Leu Leu Glu Ala Leu Glu Met Tyr Lys Asp Asp 
625                 630                 635                 640 


Trp Asn Lys Val Ser Glu His Val Gly Ser Arg Thr Gln Asp Glu Cys 
                645                 650                 655     


Ile Leu His Phe Leu Arg Leu Pro Ile Glu Asp Pro Tyr Leu Glu Asn 
            660                 665                 670         


Ser Asp Ala Ser Leu Gly Pro Leu Ala Tyr Gln Pro Val Pro Phe Ser 
        675                 680                 685             


Gln Ser Gly Asn Pro Val Met Ser Thr Val Ala Phe Leu Ala Ser Val 
    690                 695                 700                 


Val Asp Pro Arg Val Ala Ser Ala Ala Ala Lys Ala Ala Leu Glu Glu 
705                 710                 715                 720 


Phe Ser Arg Val Arg Glu Glu Val Pro Leu Glu Leu Val Glu Ala His 
                725                 730                 735     


Val Lys Lys Val Gln Glu Ala Ala Arg Ala Ser Gly Lys Val Asp Pro 
            740                 745                 750         


Thr Tyr Gly Leu Glu Ser Ser Cys Ile Ala Gly Thr Gly Pro Asp Glu 
        755                 760                 765             


Pro Glu Lys Leu Glu Gly Ser Glu Glu Glu Lys Met Glu Thr Asp Pro 
    770                 775                 780                 


Asp Gly Gln Gln Pro Glu Lys Ala Glu Asn Lys Val Glu Asn Glu Ser 
785                 790                 795                 800 


Asp Glu Gly Asp Lys Ile Gln Asp Arg Glu Asn Glu Lys Asn Thr Glu 
                805                 810                 815     


Lys Glu Gln Asp Ser Asp Val Ser Glu Asp Val Lys Pro Glu Glu Lys 
            820                 825                 830         


Glu Asn Glu Glu Asn Lys Glu Leu Thr Asp Thr Cys Lys Glu Arg Glu 
        835                 840                 845             


Ser Asp Ala Gly Lys Lys Lys Val Glu His Glu Ile Ser Glu Gly Asn 
    850                 855                 860                 


Val Ala Thr Ala Ala Ala Ala Ala Leu Ala Ser Ala Ala Thr Lys Ala 
865                 870                 875                 880 


Lys His Leu Ala Ala Val Glu Glu Arg Lys Ile Lys Ser Leu Val Ala 
                885                 890                 895     


Leu Leu Val Glu Thr Gln Met Lys Lys Leu Glu Ile Lys Leu Arg His 
            900                 905                 910         


Phe Glu Glu Leu Glu Thr Ile Met Asp Arg Glu Lys Glu Ala Leu Glu 
        915                 920                 925             


Gln Gln Arg Gln Gln Leu Leu Thr Glu Arg Gln Asn Phe His Met Glu 
    930                 935                 940                 


Gln Leu Lys Tyr Ala Glu Leu Arg Ala Arg Gln Gln Met Glu Gln Gln 
945                 950                 955                 960 


Gln Gln His Gly Gln Thr Pro Gln Gln Ala His Gln His Thr Gly Gly 
                965                 970                 975     


Pro Gly Met Ala Pro Leu Gly Ala Thr Gly His Pro Gly Met Met Pro 
            980                 985                 990         


His Gln Gln Pro Pro Pro Tyr Pro  Leu Met His His Gln  Met Pro Pro 
        995                 1000                 1005             


Pro His  Pro Pro Gln Pro Gly  Gln Ile Pro Gly Pro  Gly Ser Met 
    1010                 1015                 1020             


Met Pro  Gly Gln Pro Met Pro  Gly Arg Met Ile Pro  Ala Val Ala 
    1025                 1030                 1035             


Ala Asn  Ile His Pro Thr Gly  Ser Gly Pro Thr Pro  Pro Gly Met 
    1040                 1045                 1050             


Pro Pro  Met Pro Gly Asn Ile  Leu Gly Pro Arg Val  Pro Leu Thr 
    1055                 1060                 1065             


Ala Pro  Asn Gly Met Tyr Pro  Pro Pro Pro Gln Gln  Gln Gln Pro 
    1070                 1075                 1080             


Pro Pro  Pro Ala Asp Gly Val  Pro Pro Pro Pro Ala  Pro Gly Pro 
    1085                 1090                 1095             


Pro Ala  Ser Ala Thr Pro 
    1100                 


<210> 64
<211> 5106
<212> DNA
<213> Homo sapiens

<400> 64
ggaggcggcg gccgcggcgg cgggaggcgg cgggaggcgg gcggaggagg aggcggagga       60

ggcgggagct gagctgagtg gggcgggcgg cggcggggcc cgagccggag aagatggcgg      120

tgcggaagaa ggacggcggc cccaacgtga agtactacga ggccgcggac accgtgaccc      180

agttcgacaa cgtgcggctg tggctcggca agaactacaa gaagtatata caagctgaac      240

cacccaccaa caagtccctg tctagcctgg ttgtacagtt gctacaattt caggaagaag      300

tttttggcaa acatgtcagc aatgcaccgc tcactaaact gccgatcaaa tgtttcctag      360

atttcaaagc gggaggctcc ttgtgccaca ttcttgcagc tgcctacaaa ttcaagagtg      420

accagggatg gcggcgttac gatttccaga atccatcacg catggaccgc aatgtggaaa      480

tgtttatgac cattgagaag tccttggtgc agaataattg cctgtctcga cctaacattt      540

ttctgtgccc agaaattgag cccaaactac tagggaaatt aaaggacatt atcaagagac      600

accagggaac agtcactgag gataagaaca atgcctccca tgttgtgtat cctgtcccgg      660

ggaatctaga agaagaggaa tgggtacgac cagtcatgaa gagggataag caggttcttc      720

tgcactgggg ctactatcct gacagttacg acacgtggat cccagcgagt gaaattgagg      780

catctgtgga agatgctcca actcctgaga aacctaggaa ggttcatgca aagtggatcc      840

tggacaccga caccttcaat gaatggatga atgaggaaga ctatgaagta aatgatgaca      900

aaaaccctgt ctcccgccga aagaagattt cagccaagac actgacagat gaggtgaaca      960

gcccagattc agatcgacgg gacaagaagg ggggaaacta taagaagagg aagcgctccc     1020

cctctccttc accaacccca gaagcaaaga agaaaaatgc taagaaaggt ccctcaacac     1080

cttacactaa gtcaaagcgt ggccacagag aagaggagca agaagacctg acaaaggaca     1140

tggacgagcc ctcaccagtc cccaatgtag aagaggtgac acttcccaaa acagtcaaca     1200

caaagaaaga ctcagagtcg gccccagtca aaggcggcac catgaccgac ctggatgaac     1260

aggaagatga aagcatggag acgacgggca aggatgagga tgagaacagt acggggaaca     1320

agggagagca gaccaagaat ccagacctgc atgaggacaa tgtgactgaa cagacccacc     1380

acatcatcat tcccagctac gctgcctggt ttgactacaa tagtgttcat gccattgagc     1440

ggagggctct ccccgagttc ttcaacggca agaacaagtc caagactcca gagatctacc     1500

tggcctatcg aaactttatg attgacactt accgactgaa cccccaagag tatcttacct     1560

ctaccgcctg ccgccgaaac ctagcgggtg atgtctgtgc catcatgagg gtccatgcct     1620

tcctagaaca gtggggtctt attaactacc aggtggatgc tgagagtcga ccaaccccaa     1680

tggggcctcc gcctacctct cacttccatg tcttggctga cacaccatca gggctggtgc     1740

ctctgcagcc caagacacct cagcagacct ctgcttccca acaaatgctc aactttcctg     1800

acaaaggcaa agagaaacca acagacatgc aaaactttgg gctgcgcaca gacatgtaca     1860

caaaaaagaa tgttccctcc aagagcaagg ctgcagccag tgccactcgt gagtggacag     1920

aacaggaaac cctgcttctc ctggaggcac tggaaatgta caaagatgac tggaacaaag     1980

tgtccgagca tgtgggaagc cgcacacagg acgagtgcat cttgcatttt cttcgtcttc     2040

ccattgaaga cccatacctg gaggactcag aggcctccct aggccccctg gcctaccaac     2100

ccatcccctt cagtcagtcg ggcaaccctg ttatgagcac tgttgccttc ctggcctctg     2160

tcgtcgatcc ccgagtcgcc tctgctgctg caaagtcagc cctagaggag ttctccaaaa     2220

tgaaggaaga ggtacccacg gccttggtgg aggcccatgt tcgaaaagtg gaagaagcag     2280

ccaaagtaac aggcaaggcg gaccctgcct tcggtctgga aagcagtggc attgcaggaa     2340

ccacctctga tgagcctgag cggattgagg agagcgggaa tgacgaggct cgggtggaag     2400

gccaggccac agatgagaag aaggagccca aggaaccccg agaaggaggg ggtgctatag     2460

aggaggaagc aaaagagaaa accagcgagg ctcccaagaa ggatgaggag aaagggaaag     2520

aaggcgacag tgagaaggag tccgagaaga gtgatggaga cccaatagtc gatcctgaga     2580

aggagaagga gccaaaggaa gggcaggagg aagtgctgaa ggaagtggtg gagtctgagg     2640

gggaaaggaa gacaaaggtg gagcgggaca ttggcgaggg caacctctcc accgctgctg     2700

ccgccgccct ggccgccgcc gcagtgaaag ctaagcactt ggctgctgtt gaggaaagga     2760

agatcaaatc tttggtggcc ctgctggtgg agacccagat gaaaaagttg gagatcaaac     2820

ttcggcactt tgaggagctg gagactatca tggaccggga gcgagaagca ctggagtatc     2880

agaggcagca gctcctggcc gacagacaag ccttccacat ggagcagctg aagtatgcgg     2940

agatgagggc tcggcagcag cacttccaac agatgcacca acagcagcag cagccaccac     3000

cagccctgcc cccaggctcc cagcctatcc ccccaacagg ggctgctggg ccacccgcag     3060

tccatggctt ggctgtggct ccagcctctg tagtccctgc tcctgctggc agtggggccc     3120

ctccaggaag tttgggccct tctgaacaga ttgggcaggc agggtcaact gcagggccac     3180

agcagcagca accagctgga gccccccagc ctggggcagt cccaccaggg gttccccccc     3240

ctggacccca tggcccctca ccgttcccca accaacaaac tcctccctca atgatgccag     3300

gggcagtgcc aggcagcggg cacccaggcg tggcgggtaa tgctcctttg ggtttgcctt     3360

ttggcatgcc gcctcctcct cctcctcctg ctccatccat catcccattt ggtagtctag     3420

ctgactccat cagtattaac ctccccgctc ctcctaacct gcatgggcat caccaccatc     3480

tcccgttcgc cccgggcact ctccccccac ctaacctgcc tgtgtccatg gcgaaccctc     3540

tacatcctaa cctgccggcg accaccacca tgccatcttc cttgcctctc gggccggggc     3600

tcggatccgc cgcagcccaa agccctgcca ttgtggcagc tgttcagggc aacctcctgc     3660

ccagtgccag cccactgcca gacccaggca cccccctgcc tccagacccc acagccccga     3720

gcccaggcac ggtcacccct gtgccacctc cacagtgagg agccagccag acatctctcc     3780

ccctcacccc ctgtggacat cacggttcca ggaacagccc ttcccccacc actgggaccc     3840

tccccagcct ggagagttca tcactacgta aggaaagctc cttccgcccc tccaaagccc     3900

tcaccatgcc taacagaggc atgcattttt atatcagatt attcaaggac ttctgtttaa     3960

aagatgttta taatgtctgg gagagaggat aggatgggaa tgctgcccta aaggaagggc     4020

tggtgaaagg tgtttataca aggttctatt aaccacttct aagggtacac ctccctccaa     4080

actactgcat tttctatgga ttaaaaaaaa aaaaaaaaag tagattttaa aaagccacat     4140

tggagctccc ttctacccac taaaaaataa ccaattttta cattttttga gggggagtga     4200

gttttaggaa aggggaatta agattccagg gagagctctg gggatagaac agggcgcaga     4260

ttccatctct ccccaagccc ctttttagtg actaagtcaa ggccccaact cccctccccc     4320

accctacgct gagcttattc gagttcattc gtactaataa tccctcctgc ggcttcctca     4380

ttgttgctgt tttaggccac cccagctcag ccaatgattc ctttccctct gaatgtcagt     4440

tttgttttta aaagtcactt gcttagttga tgtcagcgta tgtgtatttg gtggggaaaa     4500

cctaatttcg gggatttctg tggtaggtaa taggagaaga aagggcactg ggggctgttc     4560

tccttccttc cctgggctgt atccatggac tcctggaagg cacagagaag ggagctataa     4620

gaggatgtga agttttaaaa cctgaaattg ttttttaaag cacttaagca cctccatatt     4680

atgacttggt gggtcacccc ttagcttcct ccctctccca ccaagactat gagaacttca     4740

gctgatagct gggggctccc cagatgagga tgcagggatt tgggagcagt ggaagagggt     4800

gcccaacctt gggttggacc aacccttggc tcgcagctca actctgcttc ccgcattcct     4860

gctccacgtg tcccagcttc tcccctgtga cgggaaggca ggtgtgactc caggctctgc     4920

actggttctt cttggttcct cccaccaggc cctttgttcc tcatgtcccc atgtttctct     4980

ccctctgcgt cttagcacct ttcttctgtt caaagttttc tgtaaatttt ctcttttttt     5040

ctttctttct tttttttttt tttataaatt aatttgcttt cagttccaaa aaaaaaaaaa     5100

aaaaaa                                                                5106


<210> 65
<211> 1214
<212> PRT
<213> Homo sapiens

<400> 65
Met Ala Val Arg Lys Lys Asp Gly Gly Pro Asn Val Lys Tyr Tyr Glu 
1               5                   10                  15      


Ala Ala Asp Thr Val Thr Gln Phe Asp Asn Val Arg Leu Trp Leu Gly 
            20                  25                  30          


Lys Asn Tyr Lys Lys Tyr Ile Gln Ala Glu Pro Pro Thr Asn Lys Ser 
        35                  40                  45              


Leu Ser Ser Leu Val Val Gln Leu Leu Gln Phe Gln Glu Glu Val Phe 
    50                  55                  60                  


Gly Lys His Val Ser Asn Ala Pro Leu Thr Lys Leu Pro Ile Lys Cys 
65                  70                  75                  80  


Phe Leu Asp Phe Lys Ala Gly Gly Ser Leu Cys His Ile Leu Ala Ala 
                85                  90                  95      


Ala Tyr Lys Phe Lys Ser Asp Gln Gly Trp Arg Arg Tyr Asp Phe Gln 
            100                 105                 110         


Asn Pro Ser Arg Met Asp Arg Asn Val Glu Met Phe Met Thr Ile Glu 
        115                 120                 125             


Lys Ser Leu Val Gln Asn Asn Cys Leu Ser Arg Pro Asn Ile Phe Leu 
    130                 135                 140                 


Cys Pro Glu Ile Glu Pro Lys Leu Leu Gly Lys Leu Lys Asp Ile Ile 
145                 150                 155                 160 


Lys Arg His Gln Gly Thr Val Thr Glu Asp Lys Asn Asn Ala Ser His 
                165                 170                 175     


Val Val Tyr Pro Val Pro Gly Asn Leu Glu Glu Glu Glu Trp Val Arg 
            180                 185                 190         


Pro Val Met Lys Arg Asp Lys Gln Val Leu Leu His Trp Gly Tyr Tyr 
        195                 200                 205             


Pro Asp Ser Tyr Asp Thr Trp Ile Pro Ala Ser Glu Ile Glu Ala Ser 
    210                 215                 220                 


Val Glu Asp Ala Pro Thr Pro Glu Lys Pro Arg Lys Val His Ala Lys 
225                 230                 235                 240 


Trp Ile Leu Asp Thr Asp Thr Phe Asn Glu Trp Met Asn Glu Glu Asp 
                245                 250                 255     


Tyr Glu Val Asn Asp Asp Lys Asn Pro Val Ser Arg Arg Lys Lys Ile 
            260                 265                 270         


Ser Ala Lys Thr Leu Thr Asp Glu Val Asn Ser Pro Asp Ser Asp Arg 
        275                 280                 285             


Arg Asp Lys Lys Gly Gly Asn Tyr Lys Lys Arg Lys Arg Ser Pro Ser 
    290                 295                 300                 


Pro Ser Pro Thr Pro Glu Ala Lys Lys Lys Asn Ala Lys Lys Gly Pro 
305                 310                 315                 320 


Ser Thr Pro Tyr Thr Lys Ser Lys Arg Gly His Arg Glu Glu Glu Gln 
                325                 330                 335     


Glu Asp Leu Thr Lys Asp Met Asp Glu Pro Ser Pro Val Pro Asn Val 
            340                 345                 350         


Glu Glu Val Thr Leu Pro Lys Thr Val Asn Thr Lys Lys Asp Ser Glu 
        355                 360                 365             


Ser Ala Pro Val Lys Gly Gly Thr Met Thr Asp Leu Asp Glu Gln Glu 
    370                 375                 380                 


Asp Glu Ser Met Glu Thr Thr Gly Lys Asp Glu Asp Glu Asn Ser Thr 
385                 390                 395                 400 


Gly Asn Lys Gly Glu Gln Thr Lys Asn Pro Asp Leu His Glu Asp Asn 
                405                 410                 415     


Val Thr Glu Gln Thr His His Ile Ile Ile Pro Ser Tyr Ala Ala Trp 
            420                 425                 430         


Phe Asp Tyr Asn Ser Val His Ala Ile Glu Arg Arg Ala Leu Pro Glu 
        435                 440                 445             


Phe Phe Asn Gly Lys Asn Lys Ser Lys Thr Pro Glu Ile Tyr Leu Ala 
    450                 455                 460                 


Tyr Arg Asn Phe Met Ile Asp Thr Tyr Arg Leu Asn Pro Gln Glu Tyr 
465                 470                 475                 480 


Leu Thr Ser Thr Ala Cys Arg Arg Asn Leu Ala Gly Asp Val Cys Ala 
                485                 490                 495     


Ile Met Arg Val His Ala Phe Leu Glu Gln Trp Gly Leu Ile Asn Tyr 
            500                 505                 510         


Gln Val Asp Ala Glu Ser Arg Pro Thr Pro Met Gly Pro Pro Pro Thr 
        515                 520                 525             


Ser His Phe His Val Leu Ala Asp Thr Pro Ser Gly Leu Val Pro Leu 
    530                 535                 540                 


Gln Pro Lys Thr Pro Gln Gln Thr Ser Ala Ser Gln Gln Met Leu Asn 
545                 550                 555                 560 


Phe Pro Asp Lys Gly Lys Glu Lys Pro Thr Asp Met Gln Asn Phe Gly 
                565                 570                 575     


Leu Arg Thr Asp Met Tyr Thr Lys Lys Asn Val Pro Ser Lys Ser Lys 
            580                 585                 590         


Ala Ala Ala Ser Ala Thr Arg Glu Trp Thr Glu Gln Glu Thr Leu Leu 
        595                 600                 605             


Leu Leu Glu Ala Leu Glu Met Tyr Lys Asp Asp Trp Asn Lys Val Ser 
    610                 615                 620                 


Glu His Val Gly Ser Arg Thr Gln Asp Glu Cys Ile Leu His Phe Leu 
625                 630                 635                 640 


Arg Leu Pro Ile Glu Asp Pro Tyr Leu Glu Asp Ser Glu Ala Ser Leu 
                645                 650                 655     


Gly Pro Leu Ala Tyr Gln Pro Ile Pro Phe Ser Gln Ser Gly Asn Pro 
            660                 665                 670         


Val Met Ser Thr Val Ala Phe Leu Ala Ser Val Val Asp Pro Arg Val 
        675                 680                 685             


Ala Ser Ala Ala Ala Lys Ser Ala Leu Glu Glu Phe Ser Lys Met Lys 
    690                 695                 700                 


Glu Glu Val Pro Thr Ala Leu Val Glu Ala His Val Arg Lys Val Glu 
705                 710                 715                 720 


Glu Ala Ala Lys Val Thr Gly Lys Ala Asp Pro Ala Phe Gly Leu Glu 
                725                 730                 735     


Ser Ser Gly Ile Ala Gly Thr Thr Ser Asp Glu Pro Glu Arg Ile Glu 
            740                 745                 750         


Glu Ser Gly Asn Asp Glu Ala Arg Val Glu Gly Gln Ala Thr Asp Glu 
        755                 760                 765             


Lys Lys Glu Pro Lys Glu Pro Arg Glu Gly Gly Gly Ala Ile Glu Glu 
    770                 775                 780                 


Glu Ala Lys Glu Lys Thr Ser Glu Ala Pro Lys Lys Asp Glu Glu Lys 
785                 790                 795                 800 


Gly Lys Glu Gly Asp Ser Glu Lys Glu Ser Glu Lys Ser Asp Gly Asp 
                805                 810                 815     


Pro Ile Val Asp Pro Glu Lys Glu Lys Glu Pro Lys Glu Gly Gln Glu 
            820                 825                 830         


Glu Val Leu Lys Glu Val Val Glu Ser Glu Gly Glu Arg Lys Thr Lys 
        835                 840                 845             


Val Glu Arg Asp Ile Gly Glu Gly Asn Leu Ser Thr Ala Ala Ala Ala 
    850                 855                 860                 


Ala Leu Ala Ala Ala Ala Val Lys Ala Lys His Leu Ala Ala Val Glu 
865                 870                 875                 880 


Glu Arg Lys Ile Lys Ser Leu Val Ala Leu Leu Val Glu Thr Gln Met 
                885                 890                 895     


Lys Lys Leu Glu Ile Lys Leu Arg His Phe Glu Glu Leu Glu Thr Ile 
            900                 905                 910         


Met Asp Arg Glu Arg Glu Ala Leu Glu Tyr Gln Arg Gln Gln Leu Leu 
        915                 920                 925             


Ala Asp Arg Gln Ala Phe His Met Glu Gln Leu Lys Tyr Ala Glu Met 
    930                 935                 940                 


Arg Ala Arg Gln Gln His Phe Gln Gln Met His Gln Gln Gln Gln Gln 
945                 950                 955                 960 


Pro Pro Pro Ala Leu Pro Pro Gly Ser Gln Pro Ile Pro Pro Thr Gly 
                965                 970                 975     


Ala Ala Gly Pro Pro Ala Val His Gly Leu Ala Val Ala Pro Ala Ser 
            980                 985                 990         


Val Val Pro Ala Pro Ala Gly Ser  Gly Ala Pro Pro Gly  Ser Leu Gly 
        995                 1000                 1005             


Pro Ser  Glu Gln Ile Gly Gln  Ala Gly Ser Thr Ala  Gly Pro Gln 
    1010                 1015                 1020             


Gln Gln  Gln Pro Ala Gly Ala  Pro Gln Pro Gly Ala  Val Pro Pro 
    1025                 1030                 1035             


Gly Val  Pro Pro Pro Gly Pro  His Gly Pro Ser Pro  Phe Pro Asn 
    1040                 1045                 1050             


Gln Gln  Thr Pro Pro Ser Met  Met Pro Gly Ala Val  Pro Gly Ser 
    1055                 1060                 1065             


Gly His  Pro Gly Val Ala Gly  Asn Ala Pro Leu Gly  Leu Pro Phe 
    1070                 1075                 1080             


Gly Met  Pro Pro Pro Pro Pro  Pro Pro Ala Pro Ser  Ile Ile Pro 
    1085                 1090                 1095             


Phe Gly  Ser Leu Ala Asp Ser  Ile Ser Ile Asn Leu  Pro Ala Pro 
    1100                 1105                 1110             


Pro Asn  Leu His Gly His His  His His Leu Pro Phe  Ala Pro Gly 
    1115                 1120                 1125             


Thr Leu  Pro Pro Pro Asn Leu  Pro Val Ser Met Ala  Asn Pro Leu 
    1130                 1135                 1140             


His Pro  Asn Leu Pro Ala Thr  Thr Thr Met Pro Ser  Ser Leu Pro 
    1145                 1150                 1155             


Leu Gly  Pro Gly Leu Gly Ser  Ala Ala Ala Gln Ser  Pro Ala Ile 
    1160                 1165                 1170             


Val Ala  Ala Val Gln Gly Asn  Leu Leu Pro Ser Ala  Ser Pro Leu 
    1175                 1180                 1185             


Pro Asp  Pro Gly Thr Pro Leu  Pro Pro Asp Pro Thr  Ala Pro Ser 
    1190                 1195                 1200             


Pro Gly  Thr Val Thr Pro Val  Pro Pro Pro Gln 
    1205                 1210                 


<210> 66
<211> 4854
<212> DNA
<213> Homo sapiens

<400> 66
ggaggcggcg gccgcggcgg cgggaggcgg cgggaggcgg gcggaggagg aggcggagga       60

ggcgggagct gagctgagtg gggcgggcgg cggcggggcc cgagccggag aagatggcgg      120

tgcggaagaa ggacggcggc cccaacgtga agtactacga ggccgcggac accgtgaccc      180

agttcgacaa cgtgcggctg tggctcggca agaactacaa gaagtatata caagctgaac      240

cacccaccaa caagtccctg tctagcctgg ttgtacagtt gctacaattt caggaagaag      300

tttttggcaa acatgtcagc aatgcaccgc tcactaaact gccgatcaaa tgtttcctag      360

atttcaaagc gggaggctcc ttgtgccaca ttcttgcagc tgcctacaaa ttcaagagtg      420

accagggatg gcggcgttac gatttccaga atccatcacg catggaccgc aatgtggaaa      480

tgtttatgac cattgagaag tccttggtgc agaataattg cctgtctcga cctaacattt      540

ttctgtgccc agaaattgag cccaaactac tagggaaatt aaaggacatt atcaagagac      600

accagggaac agtcactgag gataagaaca atgcctccca tgttgtgtat cctgtcccgg      660

ggaatctaga agaagaggaa tgggtacgac cagtcatgaa gagggataag caggttcttc      720

tgcactgggg ctactatcct gacagttacg acacgtggat cccagcgagt gaaattgagg      780

catctgtgga agatgctcca actcctgaga aacctaggaa ggttcatgca aagtggatcc      840

tggacaccga caccttcaat gaatggatga atgaggaaga ctatgaagta aatgatgaca      900

aaaaccctgt ctcccgccga aagaagattt cagccaagac actgacagat gaggtgaaca      960

gcccagattc agatcgacgg gacaagaagg ggggaaacta taagaagagg aagcgctccc     1020

cctctccttc accaacccca gaagcaaaga agaaaaatgc taagaaaggt ccctcaacac     1080

cttacactaa gtcaaagcgt ggccacagag aagaggagca agaagacctg acaaaggaca     1140

tggacgagcc ctcaccagtc cccaatgtag aagaggtgac acttcccaaa acagtcaaca     1200

caaagaaaga ctcagagtcg gccccagtca aaggcggcac catgaccgac ctggatgaac     1260

aggaagatga aagcatggag acgacgggca aggatgagga tgagaacagt acggggaaca     1320

agggagagca gaccaagaat ccagacctgc atgaggacaa tgtgactgaa cagacccacc     1380

acatcatcat tcccagctac gctgcctggt ttgactacaa tagtgttcat gccattgagc     1440

ggagggctct ccccgagttc ttcaacggca agaacaagtc caagactcca gagatctacc     1500

tggcctatcg aaactttatg attgacactt accgactgaa cccccaagag tatcttacct     1560

ctaccgcctg ccgccgaaac ctagcgggtg atgtctgtgc catcatgagg gtccatgcct     1620

tcctagaaca gtggggtctt attaactacc aggtggatgc tgagagtcga ccaaccccaa     1680

tggggcctcc gcctacctct cacttccatg tcttggctga cacaccatca gggctggtgc     1740

ctctgcagcc caagacacct cagggccgcc aggttgatgc tgataccaag gctgggcgaa     1800

agggcaaaga gctggatgac ctggtgccag agacggctaa gggcaagcca gagctgcaga     1860

cctctgcttc ccaacaaatg ctcaactttc ctgacaaagg caaagagaaa ccaacagaca     1920

tgcaaaactt tgggctgcgc acagacatgt acacaaaaaa gaatgttccc tccaagagca     1980

aggctgcagc cagtgccact cgtgagtgga cagaacagga aaccctgctt ctcctggagg     2040

cactggaaat gtacaaagat gactggaaca aagtgtccga gcatgtggga agccgcacac     2100

aggacgagtg catcttgcat tttcttcgtc ttcccattga agacccatac ctggaggact     2160

cagaggcctc cctaggcccc ctggcctacc aacccatccc cttcagtcag tcgggcaacc     2220

ctgttatgag cactgttgcc ttcctggcct ctgtcgtcga tccccgagtc gcctctgctg     2280

ctgcaaagtc agccctagag gagttctcca aaatgaagga agaggtaccc acggccttgg     2340

tggaggccca tgttcgaaaa gtggaagaag cagccaaagt aacaggcaag gcggaccctg     2400

ccttcggtct ggaaagcagt ggcattgcag gaaccacctc tgatgagcct gagcggattg     2460

aggagagcgg gaatgacgag gctcgggtgg aaggccaggc cacagatgag aagaaggagc     2520

ccaaggaacc ccgagaagga gggggtgcta tagaggagga agcaaaagag aaaaccagcg     2580

aggctcccaa gaaggatgag gagaaaggga aagaaggcga cagtgagaag gagtccgaga     2640

agagtgatgg agacccaata gtcgatcctg agaaggagaa ggagccaaag gaagggcagg     2700

aggaagtgct gaaggaagtg gtggagtctg agggggaaag gaagacaaag gtggagcggg     2760

acattggcga gggcaacctc tccaccgctg ctgccgccgc cctggccgcc gccgcagtga     2820

aagctaagca cttggctgct gttgaggaaa ggaagatcaa atctttggtg gccctgctgg     2880

tggagaccca gatgaaaaag ttggagatca aacttcggca ctttgaggag ctggagacta     2940

tcatggaccg ggagcgagaa gcactggagt atcagaggca gcagctcctg gccgacagac     3000

aagccttcca catggagcag ctgaagtatg cggagatgag ggctcggcag cagcacttcc     3060

aacagatgca ccaacagcag cagcagccac caccagccct gcccccaggc tcccagccta     3120

tccccccaac aggggctgct gggccacccg cagtccatgg cttggctgtg gctccagcct     3180

ctgtagtccc tgctcctgct ggcagtgggg cccctccagg aagtttgggc ccttctgaac     3240

agattgggca ggcagggtca actgcagggc cacagcagca gcaaccagct ggagcccccc     3300

agcctggggc agtcccacca ggggttcccc cccctggacc ccatggcccc tcaccgttcc     3360

ccaaccaaca aactcctccc tcaatgatgc caggggcagt gccaggcagc gggcacccag     3420

gcgtggcgga cccaggcacc cccctgcctc cagaccccac agccccgagc ccaggcacgg     3480

tcacccctgt gccacctcca cagtgaggag ccagccagac atctctcccc ctcaccccct     3540

gtggacatca cggttccagg aacagccctt cccccaccac tgggaccctc cccagcctgg     3600

agagttcatc actacgtaag gaaagctcct tccgcccctc caaagccctc accatgccta     3660

acagaggcat gcatttttat atcagattat tcaaggactt ctgtttaaaa gatgtttata     3720

atgtctggga gagaggatag gatgggaatg ctgccctaaa ggaagggctg gtgaaaggtg     3780

tttatacaag gttctattaa ccacttctaa gggtacacct ccctccaaac tactgcattt     3840

tctatggatt aaaaaaaaaa aaaaaaagta gattttaaaa agccacattg gagctccctt     3900

ctacccacta aaaaataacc aatttttaca ttttttgagg gggagtgagt tttaggaaag     3960

gggaattaag attccaggga gagctctggg gatagaacag ggcgcagatt ccatctctcc     4020

ccaagcccct ttttagtgac taagtcaagg ccccaactcc cctcccccac cctacgctga     4080

gcttattcga gttcattcgt actaataatc cctcctgcgg cttcctcatt gttgctgttt     4140

taggccaccc cagctcagcc aatgattcct ttccctctga atgtcagttt tgtttttaaa     4200

agtcacttgc ttagttgatg tcagcgtatg tgtatttggt ggggaaaacc taatttcggg     4260

gatttctgtg gtaggtaata ggagaagaaa gggcactggg ggctgttctc cttccttccc     4320

tgggctgtat ccatggactc ctggaaggca cagagaaggg agctataaga ggatgtgaag     4380

ttttaaaacc tgaaattgtt ttttaaagca cttaagcacc tccatattat gacttggtgg     4440

gtcacccctt agcttcctcc ctctcccacc aagactatga gaacttcagc tgatagctgg     4500

gggctcccca gatgaggatg cagggatttg ggagcagtgg aagagggtgc ccaaccttgg     4560

gttggaccaa cccttggctc gcagctcaac tctgcttccc gcattcctgc tccacgtgtc     4620

ccagcttctc ccctgtgacg ggaaggcagg tgtgactcca ggctctgcac tggttcttct     4680

tggttcctcc caccaggccc tttgttcctc atgtccccat gtttctctcc ctctgcgtct     4740

tagcaccttt cttctgttca aagttttctg taaattttct ctttttttct ttctttcttt     4800

tttttttttt tataaattaa tttgctttca gttccaaaaa aaaaaaaaaa aaaa           4854


<210> 67
<211> 1130
<212> PRT
<213> Homo sapiens

<400> 67
Met Ala Val Arg Lys Lys Asp Gly Gly Pro Asn Val Lys Tyr Tyr Glu 
1               5                   10                  15      


Ala Ala Asp Thr Val Thr Gln Phe Asp Asn Val Arg Leu Trp Leu Gly 
            20                  25                  30          


Lys Asn Tyr Lys Lys Tyr Ile Gln Ala Glu Pro Pro Thr Asn Lys Ser 
        35                  40                  45              


Leu Ser Ser Leu Val Val Gln Leu Leu Gln Phe Gln Glu Glu Val Phe 
    50                  55                  60                  


Gly Lys His Val Ser Asn Ala Pro Leu Thr Lys Leu Pro Ile Lys Cys 
65                  70                  75                  80  


Phe Leu Asp Phe Lys Ala Gly Gly Ser Leu Cys His Ile Leu Ala Ala 
                85                  90                  95      


Ala Tyr Lys Phe Lys Ser Asp Gln Gly Trp Arg Arg Tyr Asp Phe Gln 
            100                 105                 110         


Asn Pro Ser Arg Met Asp Arg Asn Val Glu Met Phe Met Thr Ile Glu 
        115                 120                 125             


Lys Ser Leu Val Gln Asn Asn Cys Leu Ser Arg Pro Asn Ile Phe Leu 
    130                 135                 140                 


Cys Pro Glu Ile Glu Pro Lys Leu Leu Gly Lys Leu Lys Asp Ile Ile 
145                 150                 155                 160 


Lys Arg His Gln Gly Thr Val Thr Glu Asp Lys Asn Asn Ala Ser His 
                165                 170                 175     


Val Val Tyr Pro Val Pro Gly Asn Leu Glu Glu Glu Glu Trp Val Arg 
            180                 185                 190         


Pro Val Met Lys Arg Asp Lys Gln Val Leu Leu His Trp Gly Tyr Tyr 
        195                 200                 205             


Pro Asp Ser Tyr Asp Thr Trp Ile Pro Ala Ser Glu Ile Glu Ala Ser 
    210                 215                 220                 


Val Glu Asp Ala Pro Thr Pro Glu Lys Pro Arg Lys Val His Ala Lys 
225                 230                 235                 240 


Trp Ile Leu Asp Thr Asp Thr Phe Asn Glu Trp Met Asn Glu Glu Asp 
                245                 250                 255     


Tyr Glu Val Asn Asp Asp Lys Asn Pro Val Ser Arg Arg Lys Lys Ile 
            260                 265                 270         


Ser Ala Lys Thr Leu Thr Asp Glu Val Asn Ser Pro Asp Ser Asp Arg 
        275                 280                 285             


Arg Asp Lys Lys Gly Gly Asn Tyr Lys Lys Arg Lys Arg Ser Pro Ser 
    290                 295                 300                 


Pro Ser Pro Thr Pro Glu Ala Lys Lys Lys Asn Ala Lys Lys Gly Pro 
305                 310                 315                 320 


Ser Thr Pro Tyr Thr Lys Ser Lys Arg Gly His Arg Glu Glu Glu Gln 
                325                 330                 335     


Glu Asp Leu Thr Lys Asp Met Asp Glu Pro Ser Pro Val Pro Asn Val 
            340                 345                 350         


Glu Glu Val Thr Leu Pro Lys Thr Val Asn Thr Lys Lys Asp Ser Glu 
        355                 360                 365             


Ser Ala Pro Val Lys Gly Gly Thr Met Thr Asp Leu Asp Glu Gln Glu 
    370                 375                 380                 


Asp Glu Ser Met Glu Thr Thr Gly Lys Asp Glu Asp Glu Asn Ser Thr 
385                 390                 395                 400 


Gly Asn Lys Gly Glu Gln Thr Lys Asn Pro Asp Leu His Glu Asp Asn 
                405                 410                 415     


Val Thr Glu Gln Thr His His Ile Ile Ile Pro Ser Tyr Ala Ala Trp 
            420                 425                 430         


Phe Asp Tyr Asn Ser Val His Ala Ile Glu Arg Arg Ala Leu Pro Glu 
        435                 440                 445             


Phe Phe Asn Gly Lys Asn Lys Ser Lys Thr Pro Glu Ile Tyr Leu Ala 
    450                 455                 460                 


Tyr Arg Asn Phe Met Ile Asp Thr Tyr Arg Leu Asn Pro Gln Glu Tyr 
465                 470                 475                 480 


Leu Thr Ser Thr Ala Cys Arg Arg Asn Leu Ala Gly Asp Val Cys Ala 
                485                 490                 495     


Ile Met Arg Val His Ala Phe Leu Glu Gln Trp Gly Leu Ile Asn Tyr 
            500                 505                 510         


Gln Val Asp Ala Glu Ser Arg Pro Thr Pro Met Gly Pro Pro Pro Thr 
        515                 520                 525             


Ser His Phe His Val Leu Ala Asp Thr Pro Ser Gly Leu Val Pro Leu 
    530                 535                 540                 


Gln Pro Lys Thr Pro Gln Gly Arg Gln Val Asp Ala Asp Thr Lys Ala 
545                 550                 555                 560 


Gly Arg Lys Gly Lys Glu Leu Asp Asp Leu Val Pro Glu Thr Ala Lys 
                565                 570                 575     


Gly Lys Pro Glu Leu Gln Thr Ser Ala Ser Gln Gln Met Leu Asn Phe 
            580                 585                 590         


Pro Asp Lys Gly Lys Glu Lys Pro Thr Asp Met Gln Asn Phe Gly Leu 
        595                 600                 605             


Arg Thr Asp Met Tyr Thr Lys Lys Asn Val Pro Ser Lys Ser Lys Ala 
    610                 615                 620                 


Ala Ala Ser Ala Thr Arg Glu Trp Thr Glu Gln Glu Thr Leu Leu Leu 
625                 630                 635                 640 


Leu Glu Ala Leu Glu Met Tyr Lys Asp Asp Trp Asn Lys Val Ser Glu 
                645                 650                 655     


His Val Gly Ser Arg Thr Gln Asp Glu Cys Ile Leu His Phe Leu Arg 
            660                 665                 670         


Leu Pro Ile Glu Asp Pro Tyr Leu Glu Asp Ser Glu Ala Ser Leu Gly 
        675                 680                 685             


Pro Leu Ala Tyr Gln Pro Ile Pro Phe Ser Gln Ser Gly Asn Pro Val 
    690                 695                 700                 


Met Ser Thr Val Ala Phe Leu Ala Ser Val Val Asp Pro Arg Val Ala 
705                 710                 715                 720 


Ser Ala Ala Ala Lys Ser Ala Leu Glu Glu Phe Ser Lys Met Lys Glu 
                725                 730                 735     


Glu Val Pro Thr Ala Leu Val Glu Ala His Val Arg Lys Val Glu Glu 
            740                 745                 750         


Ala Ala Lys Val Thr Gly Lys Ala Asp Pro Ala Phe Gly Leu Glu Ser 
        755                 760                 765             


Ser Gly Ile Ala Gly Thr Thr Ser Asp Glu Pro Glu Arg Ile Glu Glu 
    770                 775                 780                 


Ser Gly Asn Asp Glu Ala Arg Val Glu Gly Gln Ala Thr Asp Glu Lys 
785                 790                 795                 800 


Lys Glu Pro Lys Glu Pro Arg Glu Gly Gly Gly Ala Ile Glu Glu Glu 
                805                 810                 815     


Ala Lys Glu Lys Thr Ser Glu Ala Pro Lys Lys Asp Glu Glu Lys Gly 
            820                 825                 830         


Lys Glu Gly Asp Ser Glu Lys Glu Ser Glu Lys Ser Asp Gly Asp Pro 
        835                 840                 845             


Ile Val Asp Pro Glu Lys Glu Lys Glu Pro Lys Glu Gly Gln Glu Glu 
    850                 855                 860                 


Val Leu Lys Glu Val Val Glu Ser Glu Gly Glu Arg Lys Thr Lys Val 
865                 870                 875                 880 


Glu Arg Asp Ile Gly Glu Gly Asn Leu Ser Thr Ala Ala Ala Ala Ala 
                885                 890                 895     


Leu Ala Ala Ala Ala Val Lys Ala Lys His Leu Ala Ala Val Glu Glu 
            900                 905                 910         


Arg Lys Ile Lys Ser Leu Val Ala Leu Leu Val Glu Thr Gln Met Lys 
        915                 920                 925             


Lys Leu Glu Ile Lys Leu Arg His Phe Glu Glu Leu Glu Thr Ile Met 
    930                 935                 940                 


Asp Arg Glu Arg Glu Ala Leu Glu Tyr Gln Arg Gln Gln Leu Leu Ala 
945                 950                 955                 960 


Asp Arg Gln Ala Phe His Met Glu Gln Leu Lys Tyr Ala Glu Met Arg 
                965                 970                 975     


Ala Arg Gln Gln His Phe Gln Gln Met His Gln Gln Gln Gln Gln Pro 
            980                 985                 990         


Pro Pro Ala Leu Pro Pro Gly Ser  Gln Pro Ile Pro Pro  Thr Gly Ala 
        995                 1000                 1005             


Ala Gly  Pro Pro Ala Val His  Gly Leu Ala Val Ala  Pro Ala Ser 
    1010                 1015                 1020             


Val Val  Pro Ala Pro Ala Gly  Ser Gly Ala Pro Pro  Gly Ser Leu 
    1025                 1030                 1035             


Gly Pro  Ser Glu Gln Ile Gly  Gln Ala Gly Ser Thr  Ala Gly Pro 
    1040                 1045                 1050             


Gln Gln  Gln Gln Pro Ala Gly  Ala Pro Gln Pro Gly  Ala Val Pro 
    1055                 1060                 1065             


Pro Gly  Val Pro Pro Pro Gly  Pro His Gly Pro Ser  Pro Phe Pro 
    1070                 1075                 1080             


Asn Gln  Gln Thr Pro Pro Ser  Met Met Pro Gly Ala  Val Pro Gly 
    1085                 1090                 1095             


Ser Gly  His Pro Gly Val Ala  Asp Pro Gly Thr Pro  Leu Pro Pro 
    1100                 1105                 1110             


Asp Pro  Thr Ala Pro Ser Pro  Gly Thr Val Thr Pro  Val Pro Pro 
    1115                 1120                 1125             


Pro Gln  
    1130 


<210> 68
<211> 4920
<212> DNA
<213> Homo sapiens

<400> 68
ggaggcggcg gccgcggcgg cgggaggcgg cgggaggcgg gcggaggagg aggcggagga       60

ggcgggagct gagctgagtg gggcgggcgg cggcggggcc cgagccggag aagatggcgg      120

tgcggaagaa ggacggcggc cccaacgtga agtactacga ggccgcggac accgtgaccc      180

agttcgacaa cgtgcggctg tggctcggca agaactacaa gaagtatata caagctgaac      240

cacccaccaa caagtccctg tctagcctgg ttgtacagtt gctacaattt caggaagaag      300

tttttggcaa acatgtcagc aatgcaccgc tcactaaact gccgatcaaa tgtttcctag      360

atttcaaagc gggaggctcc ttgtgccaca ttcttgcagc tgcctacaaa ttcaagagtg      420

accagggatg gcggcgttac gatttccaga atccatcacg catggaccgc aatgtggaaa      480

tgtttatgac cattgagaag tccttggtgc agaataattg cctgtctcga cctaacattt      540

ttctgtgccc agaaattgag cccaaactac tagggaaatt aaaggacatt atcaagagac      600

accagggaac agtcactgag gataagaaca atgcctccca tgttgtgtat cctgtcccgg      660

ggaatctaga agaagaggaa tgggtacgac cagtcatgaa gagggataag caggttcttc      720

tgcactgggg ctactatcct gacagttacg acacgtggat cccagcgagt gaaattgagg      780

catctgtgga agatgctcca actcctgaga aacctaggaa ggttcatgca aagtggatcc      840

tggacaccga caccttcaat gaatggatga atgaggaaga ctatgaagta aatgatgaca      900

aaaaccctgt ctcccgccga aagaagattt cagccaagac actgacagat gaggtgaaca      960

gcccagattc agatcgacgg gacaagaagg ggggaaacta taagaagagg aagcgctccc     1020

cctctccttc accaacccca gaagcaaaga agaaaaatgc taagaaaggt ccctcaacac     1080

cttacactaa gtcaaagcgt ggccacagag aagaggagca agaagacctg acaaaggaca     1140

tggacgagcc ctcaccagtc cccaatgtag aagaggtgac acttcccaaa acagtcaaca     1200

caaagaaaga ctcagagtcg gccccagtca aaggcggcac catgaccgac ctggatgaac     1260

aggaagatga aagcatggag acgacgggca aggatgagga tgagaacagt acggggaaca     1320

agggagagca gaccaagaat ccagacctgc atgaggacaa tgtgactgaa cagacccacc     1380

acatcatcat tcccagctac gctgcctggt ttgactacaa tagtgttcat gccattgagc     1440

ggagggctct ccccgagttc ttcaacggca agaacaagtc caagactcca gagatctacc     1500

tggcctatcg aaactttatg attgacactt accgactgaa cccccaagag tatcttacct     1560

ctaccgcctg ccgccgaaac ctagcgggtg atgtctgtgc catcatgagg gtccatgcct     1620

tcctagaaca gtggggtctt attaactacc aggtggatgc tgagagtcga ccaaccccaa     1680

tggggcctcc gcctacctct cacttccatg tcttggctga cacaccatca gggctggtgc     1740

ctctgcagcc caagacacct cagggccgcc aggttgatgc tgataccaag gctgggcgaa     1800

agggcaaaga gctggatgac ctggtgccag agacggctaa gggcaagcca gagctgcaga     1860

cctctgcttc ccaacaaatg ctcaactttc ctgacaaagg caaagagaaa ccaacagaca     1920

tgcaaaactt tgggctgcgc acagacatgt acacaaaaaa gaatgttccc tccaagagca     1980

aggctgcagc cagtgccact cgtgagtgga cagaacagga aaccctgctt ctcctggagg     2040

cactggaaat gtacaaagat gactggaaca aagtgtccga gcatgtggga agccgcacac     2100

aggacgagtg catcttgcat tttcttcgtc ttcccattga agacccatac ctggaggact     2160

cagaggcctc cctaggcccc ctggcctacc aacccatccc cttcagtcag tcgggcaacc     2220

ctgttatgag cactgttgcc ttcctggcct ctgtcgtcga tccccgagtc gcctctgctg     2280

ctgcaaagtc agccctagag gagttctcca aaatgaagga agaggtaccc acggccttgg     2340

tggaggccca tgttcgaaaa gtggaagaag cagccaaagt aacaggcaag gcggaccctg     2400

ccttcggtct ggaaagcagt ggcattgcag gaaccacctc tgatgagcct gagcggattg     2460

aggagagcgg gaatgacgag gctcgggtgg aaggccaggc cacagatgag aagaaggagc     2520

ccaaggaacc ccgagaagga gggggtgcta tagaggagga agcaaaagag aaaaccagcg     2580

aggctcccaa gaaggatgag gagaaaggga aagaaggcga cagtgagaag gagtccgaga     2640

agagtgatgg agacccaata gtcgatcctg agaaggagaa ggagccaaag gaagggcagg     2700

aggaagtgct gaaggaagtg gtggagtctg agggggaaag gaagacaaag gtggagcggg     2760

acattggcga gggcaacctc tccaccgctg ctgccgccgc cctggccgcc gccgcagtga     2820

aagctaagca cttggctgct gttgaggaaa ggaagatcaa atctttggtg gccctgctgg     2880

tggagaccca gatgaaaaag ttggagatca aacttcggca ctttgaggag ctggagacta     2940

tcatggaccg ggagcgagaa gcactggagt atcagaggca gcagctcctg gccgacagac     3000

aagccttcca catggagcag ctgaagtatg cggagatgag ggctcggcag cagcacttcc     3060

aacagatgca ccaacagcag cagcagccac caccagccct gcccccaggc tcccagccta     3120

tccccccaac aggggctgct gggccacccg cagtccatgg cttggctgtg gctccagcct     3180

ctgtagtccc tgctcctgct ggcagtgggg cccctccagg aagtttgggc ccttctgaac     3240

agattgggca ggcagggtca actgcagggc cacagcagca gcaaccagct ggagcccccc     3300

agcctggggc agtcccacca ggggttcccc cccctggacc ccatggcccc tcaccgttcc     3360

ccaaccaaca aactcctccc tcaatgatgc caggggcagt gccaggcagc gggcacccag     3420

gcgtggcggc ccaaagccct gccattgtgg cagctgttca gggcaacctc ctgcccagtg     3480

ccagcccact gccagaccca ggcacccccc tgcctccaga ccccacagcc ccgagcccag     3540

gcacggtcac ccctgtgcca cctccacagt gaggagccag ccagacatct ctccccctca     3600

ccccctgtgg acatcacggt tccaggaaca gcccttcccc caccactggg accctcccca     3660

gcctggagag ttcatcacta cgtaaggaaa gctccttccg cccctccaaa gccctcacca     3720

tgcctaacag aggcatgcat ttttatatca gattattcaa ggacttctgt ttaaaagatg     3780

tttataatgt ctgggagaga ggataggatg ggaatgctgc cctaaaggaa gggctggtga     3840

aaggtgttta tacaaggttc tattaaccac ttctaagggt acacctccct ccaaactact     3900

gcattttcta tggattaaaa aaaaaaaaaa aaagtagatt ttaaaaagcc acattggagc     3960

tcccttctac ccactaaaaa ataaccaatt tttacatttt ttgaggggga gtgagtttta     4020

ggaaagggga attaagattc cagggagagc tctggggata gaacagggcg cagattccat     4080

ctctccccaa gccccttttt agtgactaag tcaaggcccc aactcccctc ccccacccta     4140

cgctgagctt attcgagttc attcgtacta ataatccctc ctgcggcttc ctcattgttg     4200

ctgttttagg ccaccccagc tcagccaatg attcctttcc ctctgaatgt cagttttgtt     4260

tttaaaagtc acttgcttag ttgatgtcag cgtatgtgta tttggtgggg aaaacctaat     4320

ttcggggatt tctgtggtag gtaataggag aagaaagggc actgggggct gttctccttc     4380

cttccctggg ctgtatccat ggactcctgg aaggcacaga gaagggagct ataagaggat     4440

gtgaagtttt aaaacctgaa attgtttttt aaagcactta agcacctcca tattatgact     4500

tggtgggtca ccccttagct tcctccctct cccaccaaga ctatgagaac ttcagctgat     4560

agctgggggc tccccagatg aggatgcagg gatttgggag cagtggaaga gggtgcccaa     4620

ccttgggttg gaccaaccct tggctcgcag ctcaactctg cttcccgcat tcctgctcca     4680

cgtgtcccag cttctcccct gtgacgggaa ggcaggtgtg actccaggct ctgcactggt     4740

tcttcttggt tcctcccacc aggccctttg ttcctcatgt ccccatgttt ctctccctct     4800

gcgtcttagc acctttcttc tgttcaaagt tttctgtaaa ttttctcttt ttttctttct     4860

ttcttttttt tttttttata aattaatttg ctttcagttc caaaaaaaaa aaaaaaaaaa     4920


<210> 69
<211> 1152
<212> PRT
<213> Homo sapiens

<400> 69
Met Ala Val Arg Lys Lys Asp Gly Gly Pro Asn Val Lys Tyr Tyr Glu 
1               5                   10                  15      


Ala Ala Asp Thr Val Thr Gln Phe Asp Asn Val Arg Leu Trp Leu Gly 
            20                  25                  30          


Lys Asn Tyr Lys Lys Tyr Ile Gln Ala Glu Pro Pro Thr Asn Lys Ser 
        35                  40                  45              


Leu Ser Ser Leu Val Val Gln Leu Leu Gln Phe Gln Glu Glu Val Phe 
    50                  55                  60                  


Gly Lys His Val Ser Asn Ala Pro Leu Thr Lys Leu Pro Ile Lys Cys 
65                  70                  75                  80  


Phe Leu Asp Phe Lys Ala Gly Gly Ser Leu Cys His Ile Leu Ala Ala 
                85                  90                  95      


Ala Tyr Lys Phe Lys Ser Asp Gln Gly Trp Arg Arg Tyr Asp Phe Gln 
            100                 105                 110         


Asn Pro Ser Arg Met Asp Arg Asn Val Glu Met Phe Met Thr Ile Glu 
        115                 120                 125             


Lys Ser Leu Val Gln Asn Asn Cys Leu Ser Arg Pro Asn Ile Phe Leu 
    130                 135                 140                 


Cys Pro Glu Ile Glu Pro Lys Leu Leu Gly Lys Leu Lys Asp Ile Ile 
145                 150                 155                 160 


Lys Arg His Gln Gly Thr Val Thr Glu Asp Lys Asn Asn Ala Ser His 
                165                 170                 175     


Val Val Tyr Pro Val Pro Gly Asn Leu Glu Glu Glu Glu Trp Val Arg 
            180                 185                 190         


Pro Val Met Lys Arg Asp Lys Gln Val Leu Leu His Trp Gly Tyr Tyr 
        195                 200                 205             


Pro Asp Ser Tyr Asp Thr Trp Ile Pro Ala Ser Glu Ile Glu Ala Ser 
    210                 215                 220                 


Val Glu Asp Ala Pro Thr Pro Glu Lys Pro Arg Lys Val His Ala Lys 
225                 230                 235                 240 


Trp Ile Leu Asp Thr Asp Thr Phe Asn Glu Trp Met Asn Glu Glu Asp 
                245                 250                 255     


Tyr Glu Val Asn Asp Asp Lys Asn Pro Val Ser Arg Arg Lys Lys Ile 
            260                 265                 270         


Ser Ala Lys Thr Leu Thr Asp Glu Val Asn Ser Pro Asp Ser Asp Arg 
        275                 280                 285             


Arg Asp Lys Lys Gly Gly Asn Tyr Lys Lys Arg Lys Arg Ser Pro Ser 
    290                 295                 300                 


Pro Ser Pro Thr Pro Glu Ala Lys Lys Lys Asn Ala Lys Lys Gly Pro 
305                 310                 315                 320 


Ser Thr Pro Tyr Thr Lys Ser Lys Arg Gly His Arg Glu Glu Glu Gln 
                325                 330                 335     


Glu Asp Leu Thr Lys Asp Met Asp Glu Pro Ser Pro Val Pro Asn Val 
            340                 345                 350         


Glu Glu Val Thr Leu Pro Lys Thr Val Asn Thr Lys Lys Asp Ser Glu 
        355                 360                 365             


Ser Ala Pro Val Lys Gly Gly Thr Met Thr Asp Leu Asp Glu Gln Glu 
    370                 375                 380                 


Asp Glu Ser Met Glu Thr Thr Gly Lys Asp Glu Asp Glu Asn Ser Thr 
385                 390                 395                 400 


Gly Asn Lys Gly Glu Gln Thr Lys Asn Pro Asp Leu His Glu Asp Asn 
                405                 410                 415     


Val Thr Glu Gln Thr His His Ile Ile Ile Pro Ser Tyr Ala Ala Trp 
            420                 425                 430         


Phe Asp Tyr Asn Ser Val His Ala Ile Glu Arg Arg Ala Leu Pro Glu 
        435                 440                 445             


Phe Phe Asn Gly Lys Asn Lys Ser Lys Thr Pro Glu Ile Tyr Leu Ala 
    450                 455                 460                 


Tyr Arg Asn Phe Met Ile Asp Thr Tyr Arg Leu Asn Pro Gln Glu Tyr 
465                 470                 475                 480 


Leu Thr Ser Thr Ala Cys Arg Arg Asn Leu Ala Gly Asp Val Cys Ala 
                485                 490                 495     


Ile Met Arg Val His Ala Phe Leu Glu Gln Trp Gly Leu Ile Asn Tyr 
            500                 505                 510         


Gln Val Asp Ala Glu Ser Arg Pro Thr Pro Met Gly Pro Pro Pro Thr 
        515                 520                 525             


Ser His Phe His Val Leu Ala Asp Thr Pro Ser Gly Leu Val Pro Leu 
    530                 535                 540                 


Gln Pro Lys Thr Pro Gln Gly Arg Gln Val Asp Ala Asp Thr Lys Ala 
545                 550                 555                 560 


Gly Arg Lys Gly Lys Glu Leu Asp Asp Leu Val Pro Glu Thr Ala Lys 
                565                 570                 575     


Gly Lys Pro Glu Leu Gln Thr Ser Ala Ser Gln Gln Met Leu Asn Phe 
            580                 585                 590         


Pro Asp Lys Gly Lys Glu Lys Pro Thr Asp Met Gln Asn Phe Gly Leu 
        595                 600                 605             


Arg Thr Asp Met Tyr Thr Lys Lys Asn Val Pro Ser Lys Ser Lys Ala 
    610                 615                 620                 


Ala Ala Ser Ala Thr Arg Glu Trp Thr Glu Gln Glu Thr Leu Leu Leu 
625                 630                 635                 640 


Leu Glu Ala Leu Glu Met Tyr Lys Asp Asp Trp Asn Lys Val Ser Glu 
                645                 650                 655     


His Val Gly Ser Arg Thr Gln Asp Glu Cys Ile Leu His Phe Leu Arg 
            660                 665                 670         


Leu Pro Ile Glu Asp Pro Tyr Leu Glu Asp Ser Glu Ala Ser Leu Gly 
        675                 680                 685             


Pro Leu Ala Tyr Gln Pro Ile Pro Phe Ser Gln Ser Gly Asn Pro Val 
    690                 695                 700                 


Met Ser Thr Val Ala Phe Leu Ala Ser Val Val Asp Pro Arg Val Ala 
705                 710                 715                 720 


Ser Ala Ala Ala Lys Ser Ala Leu Glu Glu Phe Ser Lys Met Lys Glu 
                725                 730                 735     


Glu Val Pro Thr Ala Leu Val Glu Ala His Val Arg Lys Val Glu Glu 
            740                 745                 750         


Ala Ala Lys Val Thr Gly Lys Ala Asp Pro Ala Phe Gly Leu Glu Ser 
        755                 760                 765             


Ser Gly Ile Ala Gly Thr Thr Ser Asp Glu Pro Glu Arg Ile Glu Glu 
    770                 775                 780                 


Ser Gly Asn Asp Glu Ala Arg Val Glu Gly Gln Ala Thr Asp Glu Lys 
785                 790                 795                 800 


Lys Glu Pro Lys Glu Pro Arg Glu Gly Gly Gly Ala Ile Glu Glu Glu 
                805                 810                 815     


Ala Lys Glu Lys Thr Ser Glu Ala Pro Lys Lys Asp Glu Glu Lys Gly 
            820                 825                 830         


Lys Glu Gly Asp Ser Glu Lys Glu Ser Glu Lys Ser Asp Gly Asp Pro 
        835                 840                 845             


Ile Val Asp Pro Glu Lys Glu Lys Glu Pro Lys Glu Gly Gln Glu Glu 
    850                 855                 860                 


Val Leu Lys Glu Val Val Glu Ser Glu Gly Glu Arg Lys Thr Lys Val 
865                 870                 875                 880 


Glu Arg Asp Ile Gly Glu Gly Asn Leu Ser Thr Ala Ala Ala Ala Ala 
                885                 890                 895     


Leu Ala Ala Ala Ala Val Lys Ala Lys His Leu Ala Ala Val Glu Glu 
            900                 905                 910         


Arg Lys Ile Lys Ser Leu Val Ala Leu Leu Val Glu Thr Gln Met Lys 
        915                 920                 925             


Lys Leu Glu Ile Lys Leu Arg His Phe Glu Glu Leu Glu Thr Ile Met 
    930                 935                 940                 


Asp Arg Glu Arg Glu Ala Leu Glu Tyr Gln Arg Gln Gln Leu Leu Ala 
945                 950                 955                 960 


Asp Arg Gln Ala Phe His Met Glu Gln Leu Lys Tyr Ala Glu Met Arg 
                965                 970                 975     


Ala Arg Gln Gln His Phe Gln Gln Met His Gln Gln Gln Gln Gln Pro 
            980                 985                 990         


Pro Pro Ala Leu Pro Pro Gly Ser  Gln Pro Ile Pro Pro  Thr Gly Ala 
        995                 1000                 1005             


Ala Gly  Pro Pro Ala Val His  Gly Leu Ala Val Ala  Pro Ala Ser 
    1010                 1015                 1020             


Val Val  Pro Ala Pro Ala Gly  Ser Gly Ala Pro Pro  Gly Ser Leu 
    1025                 1030                 1035             


Gly Pro  Ser Glu Gln Ile Gly  Gln Ala Gly Ser Thr  Ala Gly Pro 
    1040                 1045                 1050             


Gln Gln  Gln Gln Pro Ala Gly  Ala Pro Gln Pro Gly  Ala Val Pro 
    1055                 1060                 1065             


Pro Gly  Val Pro Pro Pro Gly  Pro His Gly Pro Ser  Pro Phe Pro 
    1070                 1075                 1080             


Asn Gln  Gln Thr Pro Pro Ser  Met Met Pro Gly Ala  Val Pro Gly 
    1085                 1090                 1095             


Ser Gly  His Pro Gly Val Ala  Ala Gln Ser Pro Ala  Ile Val Ala 
    1100                 1105                 1110             


Ala Val  Gln Gly Asn Leu Leu  Pro Ser Ala Ser Pro  Leu Pro Asp 
    1115                 1120                 1125             


Pro Gly  Thr Pro Leu Pro Pro  Asp Pro Thr Ala Pro  Ser Pro Gly 
    1130                 1135                 1140             


Thr Val  Thr Pro Val Pro Pro  Pro Gln 
    1145                 1150         


<210> 70
<211> 5199
<212> DNA
<213> Homo sapiens

<400> 70
ggaggcggcg gccgcggcgg cgggaggcgg cgggaggcgg gcggaggagg aggcggagga       60

ggcgggagct gagctgagtg gggcgggcgg cggcggggcc cgagccggag aagatggcgg      120

tgcggaagaa ggacggcggc cccaacgtga agtactacga ggccgcggac accgtgaccc      180

agttcgacaa cgtgcggctg tggctcggca agaactacaa gaagtatata caagctgaac      240

cacccaccaa caagtccctg tctagcctgg ttgtacagtt gctacaattt caggaagaag      300

tttttggcaa acatgtcagc aatgcaccgc tcactaaact gccgatcaaa tgtttcctag      360

atttcaaagc gggaggctcc ttgtgccaca ttcttgcagc tgcctacaaa ttcaagagtg      420

accagggatg gcggcgttac gatttccaga atccatcacg catggaccgc aatgtggaaa      480

tgtttatgac cattgagaag tccttggtgc agaataattg cctgtctcga cctaacattt      540

ttctgtgccc agaaattgag cccaaactac tagggaaatt aaaggacatt atcaagagac      600

accagggaac agtcactgag gataagaaca atgcctccca tgttgtgtat cctgtcccgg      660

ggaatctaga agaagaggaa tgggtacgac cagtcatgaa gagggataag caggttcttc      720

tgcactgggg ctactatcct gacagttacg acacgtggat cccagcgagt gaaattgagg      780

catctgtgga agatgctcca actcctgaga aacctaggaa ggttcatgca aagtggatcc      840

tggacaccga caccttcaat gaatggatga atgaggaaga ctatgaagta aatgatgaca      900

aaaaccctgt ctcccgccga aagaagattt cagccaagac actgacagat gaggtgaaca      960

gcccagattc agatcgacgg gacaagaagg ggggaaacta taagaagagg aagcgctccc     1020

cctctccttc accaacccca gaagcaaaga agaaaaatgc taagaaaggt ccctcaacac     1080

cttacactaa gtcaaagcgt ggccacagag aagaggagca agaagacctg acaaaggaca     1140

tggacgagcc ctcaccagtc cccaatgtag aagaggtgac acttcccaaa acagtcaaca     1200

caaagaaaga ctcagagtcg gccccagtca aaggcggcac catgaccgac ctggatgaac     1260

aggaagatga aagcatggag acgacgggca aggatgagga tgagaacagt acggggaaca     1320

agggagagca gaccaagaat ccagacctgc atgaggacaa tgtgactgaa cagacccacc     1380

acatcatcat tcccagctac gctgcctggt ttgactacaa tagtgttcat gccattgagc     1440

ggagggctct ccccgagttc ttcaacggca agaacaagtc caagactcca gagatctacc     1500

tggcctatcg aaactttatg attgacactt accgactgaa cccccaagag tatcttacct     1560

ctaccgcctg ccgccgaaac ctagcgggtg atgtctgtgc catcatgagg gtccatgcct     1620

tcctagaaca gtggggtctt attaactacc aggtggatgc tgagagtcga ccaaccccaa     1680

tggggcctcc gcctacctct cacttccatg tcttggctga cacaccatca gggctggtgc     1740

ctctgcagcc caagacacct cagggccgcc aggttgatgc tgataccaag gctgggcgaa     1800

agggcaaaga gctggatgac ctggtgccag agacggctaa gggcaagcca gagctgcaga     1860

cctctgcttc ccaacaaatg ctcaactttc ctgacaaagg caaagagaaa ccaacagaca     1920

tgcaaaactt tgggctgcgc acagacatgt acacaaaaaa gaatgttccc tccaagagca     1980

aggctgcagc cagtgccact cgtgagtgga cagaacagga aaccctgctt ctcctggagg     2040

cactggaaat gtacaaagat gactggaaca aagtgtccga gcatgtggga agccgcacac     2100

aggacgagtg catcttgcat tttcttcgtc ttcccattga agacccatac ctggaggact     2160

cagaggcctc cctaggcccc ctggcctacc aacccatccc cttcagtcag tcgggcaacc     2220

ctgttatgag cactgttgcc ttcctggcct ctgtcgtcga tccccgagtc gcctctgctg     2280

ctgcaaagtc agccctagag gagttctcca aaatgaagga agaggtaccc acggccttgg     2340

tggaggccca tgttcgaaaa gtggaagaag cagccaaagt aacaggcaag gcggaccctg     2400

ccttcggtct ggaaagcagt ggcattgcag gaaccacctc tgatgagcct gagcggattg     2460

aggagagcgg gaatgacgag gctcgggtgg aaggccaggc cacagatgag aagaaggagc     2520

ccaaggaacc ccgagaagga gggggtgcta tagaggagga agcaaaagag aaaaccagcg     2580

aggctcccaa gaaggatgag gagaaaggga aagaaggcga cagtgagaag gagtccgaga     2640

agagtgatgg agacccaata gtcgatcctg agaaggagaa ggagccaaag gaagggcagg     2700

aggaagtgct gaaggaagtg gtggagtctg agggggaaag gaagacaaag gtggagcggg     2760

acattggcga gggcaacctc tccaccgctg ctgccgccgc cctggccgcc gccgcagtga     2820

aagctaagca cttggctgct gttgaggaaa ggaagatcaa atctttggtg gccctgctgg     2880

tggagaccca gatgaaaaag ttggagatca aacttcggca ctttgaggag ctggagacta     2940

tcatggaccg ggagcgagaa gcactggagt atcagaggca gcagctcctg gccgacagac     3000

aagccttcca catggagcag ctgaagtatg cggagatgag ggctcggcag cagcacttcc     3060

aacagatgca ccaacagcag cagcagccac caccagccct gcccccaggc tcccagccta     3120

tccccccaac aggggctgct gggccacccg cagtccatgg cttggctgtg gctccagcct     3180

ctgtagtccc tgctcctgct ggcagtgggg cccctccagg aagtttgggc ccttctgaac     3240

agattgggca ggcagggtca actgcagggc cacagcagca gcaaccagct ggagcccccc     3300

agcctggggc agtcccacca ggggttcccc cccctggacc ccatggcccc tcaccgttcc     3360

ccaaccaaca aactcctccc tcaatgatgc caggggcagt gccaggcagc gggcacccag     3420

gcgtggcggg taatgctcct ttgggtttgc cttttggcat gccgcctcct cctcctcctc     3480

ctgctccatc catcatccca tttggtagtc tagctgactc catcagtatt aacctccccg     3540

ctcctcctaa cctgcatggg catcaccacc atctcccgtt cgccccgggc actctccccc     3600

cacctaacct gcctgtgtcc atggcgaacc ctctacatcc taacctgccg gcgaccacca     3660

ccatgccatc ttccttgcct ctcgggccgg ggctcggatc cgccgcagcc caaagccctg     3720

ccattgtggc agctgttcag ggcaacctcc tgcccagtgc cagcccactg ccagacccag     3780

gcacccccct gcctccagac cccacagccc cgagcccagg cacggtcacc cctgtgccac     3840

ctccacagtg aggagccagc cagacatctc tccccctcac cccctgtgga catcacggtt     3900

ccaggaacag cccttccccc accactggga ccctccccag cctggagagt tcatcactac     3960

gtaaggaaag ctccttccgc ccctccaaag ccctcaccat gcctaacaga ggcatgcatt     4020

tttatatcag attattcaag gacttctgtt taaaagatgt ttataatgtc tgggagagag     4080

gataggatgg gaatgctgcc ctaaaggaag ggctggtgaa aggtgtttat acaaggttct     4140

attaaccact tctaagggta cacctccctc caaactactg cattttctat ggattaaaaa     4200

aaaaaaaaaa aagtagattt taaaaagcca cattggagct cccttctacc cactaaaaaa     4260

taaccaattt ttacattttt tgagggggag tgagttttag gaaaggggaa ttaagattcc     4320

agggagagct ctggggatag aacagggcgc agattccatc tctccccaag ccccttttta     4380

gtgactaagt caaggcccca actcccctcc cccaccctac gctgagctta ttcgagttca     4440

ttcgtactaa taatccctcc tgcggcttcc tcattgttgc tgttttaggc caccccagct     4500

cagccaatga ttcctttccc tctgaatgtc agttttgttt ttaaaagtca cttgcttagt     4560

tgatgtcagc gtatgtgtat ttggtgggga aaacctaatt tcggggattt ctgtggtagg     4620

taataggaga agaaagggca ctgggggctg ttctccttcc ttccctgggc tgtatccatg     4680

gactcctgga aggcacagag aagggagcta taagaggatg tgaagtttta aaacctgaaa     4740

ttgtttttta aagcacttaa gcacctccat attatgactt ggtgggtcac cccttagctt     4800

cctccctctc ccaccaagac tatgagaact tcagctgata gctgggggct ccccagatga     4860

ggatgcaggg atttgggagc agtggaagag ggtgcccaac cttgggttgg accaaccctt     4920

ggctcgcagc tcaactctgc ttcccgcatt cctgctccac gtgtcccagc ttctcccctg     4980

tgacgggaag gcaggtgtga ctccaggctc tgcactggtt cttcttggtt cctcccacca     5040

ggccctttgt tcctcatgtc cccatgtttc tctccctctg cgtcttagca cctttcttct     5100

gttcaaagtt ttctgtaaat tttctctttt tttctttctt tctttttttt ttttttataa     5160

attaatttgc tttcagttcc aaaaaaaaaa aaaaaaaaa                            5199


<210> 71
<211> 1245
<212> PRT
<213> Homo sapiens

<400> 71
Met Ala Val Arg Lys Lys Asp Gly Gly Pro Asn Val Lys Tyr Tyr Glu 
1               5                   10                  15      


Ala Ala Asp Thr Val Thr Gln Phe Asp Asn Val Arg Leu Trp Leu Gly 
            20                  25                  30          


Lys Asn Tyr Lys Lys Tyr Ile Gln Ala Glu Pro Pro Thr Asn Lys Ser 
        35                  40                  45              


Leu Ser Ser Leu Val Val Gln Leu Leu Gln Phe Gln Glu Glu Val Phe 
    50                  55                  60                  


Gly Lys His Val Ser Asn Ala Pro Leu Thr Lys Leu Pro Ile Lys Cys 
65                  70                  75                  80  


Phe Leu Asp Phe Lys Ala Gly Gly Ser Leu Cys His Ile Leu Ala Ala 
                85                  90                  95      


Ala Tyr Lys Phe Lys Ser Asp Gln Gly Trp Arg Arg Tyr Asp Phe Gln 
            100                 105                 110         


Asn Pro Ser Arg Met Asp Arg Asn Val Glu Met Phe Met Thr Ile Glu 
        115                 120                 125             


Lys Ser Leu Val Gln Asn Asn Cys Leu Ser Arg Pro Asn Ile Phe Leu 
    130                 135                 140                 


Cys Pro Glu Ile Glu Pro Lys Leu Leu Gly Lys Leu Lys Asp Ile Ile 
145                 150                 155                 160 


Lys Arg His Gln Gly Thr Val Thr Glu Asp Lys Asn Asn Ala Ser His 
                165                 170                 175     


Val Val Tyr Pro Val Pro Gly Asn Leu Glu Glu Glu Glu Trp Val Arg 
            180                 185                 190         


Pro Val Met Lys Arg Asp Lys Gln Val Leu Leu His Trp Gly Tyr Tyr 
        195                 200                 205             


Pro Asp Ser Tyr Asp Thr Trp Ile Pro Ala Ser Glu Ile Glu Ala Ser 
    210                 215                 220                 


Val Glu Asp Ala Pro Thr Pro Glu Lys Pro Arg Lys Val His Ala Lys 
225                 230                 235                 240 


Trp Ile Leu Asp Thr Asp Thr Phe Asn Glu Trp Met Asn Glu Glu Asp 
                245                 250                 255     


Tyr Glu Val Asn Asp Asp Lys Asn Pro Val Ser Arg Arg Lys Lys Ile 
            260                 265                 270         


Ser Ala Lys Thr Leu Thr Asp Glu Val Asn Ser Pro Asp Ser Asp Arg 
        275                 280                 285             


Arg Asp Lys Lys Gly Gly Asn Tyr Lys Lys Arg Lys Arg Ser Pro Ser 
    290                 295                 300                 


Pro Ser Pro Thr Pro Glu Ala Lys Lys Lys Asn Ala Lys Lys Gly Pro 
305                 310                 315                 320 


Ser Thr Pro Tyr Thr Lys Ser Lys Arg Gly His Arg Glu Glu Glu Gln 
                325                 330                 335     


Glu Asp Leu Thr Lys Asp Met Asp Glu Pro Ser Pro Val Pro Asn Val 
            340                 345                 350         


Glu Glu Val Thr Leu Pro Lys Thr Val Asn Thr Lys Lys Asp Ser Glu 
        355                 360                 365             


Ser Ala Pro Val Lys Gly Gly Thr Met Thr Asp Leu Asp Glu Gln Glu 
    370                 375                 380                 


Asp Glu Ser Met Glu Thr Thr Gly Lys Asp Glu Asp Glu Asn Ser Thr 
385                 390                 395                 400 


Gly Asn Lys Gly Glu Gln Thr Lys Asn Pro Asp Leu His Glu Asp Asn 
                405                 410                 415     


Val Thr Glu Gln Thr His His Ile Ile Ile Pro Ser Tyr Ala Ala Trp 
            420                 425                 430         


Phe Asp Tyr Asn Ser Val His Ala Ile Glu Arg Arg Ala Leu Pro Glu 
        435                 440                 445             


Phe Phe Asn Gly Lys Asn Lys Ser Lys Thr Pro Glu Ile Tyr Leu Ala 
    450                 455                 460                 


Tyr Arg Asn Phe Met Ile Asp Thr Tyr Arg Leu Asn Pro Gln Glu Tyr 
465                 470                 475                 480 


Leu Thr Ser Thr Ala Cys Arg Arg Asn Leu Ala Gly Asp Val Cys Ala 
                485                 490                 495     


Ile Met Arg Val His Ala Phe Leu Glu Gln Trp Gly Leu Ile Asn Tyr 
            500                 505                 510         


Gln Val Asp Ala Glu Ser Arg Pro Thr Pro Met Gly Pro Pro Pro Thr 
        515                 520                 525             


Ser His Phe His Val Leu Ala Asp Thr Pro Ser Gly Leu Val Pro Leu 
    530                 535                 540                 


Gln Pro Lys Thr Pro Gln Gly Arg Gln Val Asp Ala Asp Thr Lys Ala 
545                 550                 555                 560 


Gly Arg Lys Gly Lys Glu Leu Asp Asp Leu Val Pro Glu Thr Ala Lys 
                565                 570                 575     


Gly Lys Pro Glu Leu Gln Thr Ser Ala Ser Gln Gln Met Leu Asn Phe 
            580                 585                 590         


Pro Asp Lys Gly Lys Glu Lys Pro Thr Asp Met Gln Asn Phe Gly Leu 
        595                 600                 605             


Arg Thr Asp Met Tyr Thr Lys Lys Asn Val Pro Ser Lys Ser Lys Ala 
    610                 615                 620                 


Ala Ala Ser Ala Thr Arg Glu Trp Thr Glu Gln Glu Thr Leu Leu Leu 
625                 630                 635                 640 


Leu Glu Ala Leu Glu Met Tyr Lys Asp Asp Trp Asn Lys Val Ser Glu 
                645                 650                 655     


His Val Gly Ser Arg Thr Gln Asp Glu Cys Ile Leu His Phe Leu Arg 
            660                 665                 670         


Leu Pro Ile Glu Asp Pro Tyr Leu Glu Asp Ser Glu Ala Ser Leu Gly 
        675                 680                 685             


Pro Leu Ala Tyr Gln Pro Ile Pro Phe Ser Gln Ser Gly Asn Pro Val 
    690                 695                 700                 


Met Ser Thr Val Ala Phe Leu Ala Ser Val Val Asp Pro Arg Val Ala 
705                 710                 715                 720 


Ser Ala Ala Ala Lys Ser Ala Leu Glu Glu Phe Ser Lys Met Lys Glu 
                725                 730                 735     


Glu Val Pro Thr Ala Leu Val Glu Ala His Val Arg Lys Val Glu Glu 
            740                 745                 750         


Ala Ala Lys Val Thr Gly Lys Ala Asp Pro Ala Phe Gly Leu Glu Ser 
        755                 760                 765             


Ser Gly Ile Ala Gly Thr Thr Ser Asp Glu Pro Glu Arg Ile Glu Glu 
    770                 775                 780                 


Ser Gly Asn Asp Glu Ala Arg Val Glu Gly Gln Ala Thr Asp Glu Lys 
785                 790                 795                 800 


Lys Glu Pro Lys Glu Pro Arg Glu Gly Gly Gly Ala Ile Glu Glu Glu 
                805                 810                 815     


Ala Lys Glu Lys Thr Ser Glu Ala Pro Lys Lys Asp Glu Glu Lys Gly 
            820                 825                 830         


Lys Glu Gly Asp Ser Glu Lys Glu Ser Glu Lys Ser Asp Gly Asp Pro 
        835                 840                 845             


Ile Val Asp Pro Glu Lys Glu Lys Glu Pro Lys Glu Gly Gln Glu Glu 
    850                 855                 860                 


Val Leu Lys Glu Val Val Glu Ser Glu Gly Glu Arg Lys Thr Lys Val 
865                 870                 875                 880 


Glu Arg Asp Ile Gly Glu Gly Asn Leu Ser Thr Ala Ala Ala Ala Ala 
                885                 890                 895     


Leu Ala Ala Ala Ala Val Lys Ala Lys His Leu Ala Ala Val Glu Glu 
            900                 905                 910         


Arg Lys Ile Lys Ser Leu Val Ala Leu Leu Val Glu Thr Gln Met Lys 
        915                 920                 925             


Lys Leu Glu Ile Lys Leu Arg His Phe Glu Glu Leu Glu Thr Ile Met 
    930                 935                 940                 


Asp Arg Glu Arg Glu Ala Leu Glu Tyr Gln Arg Gln Gln Leu Leu Ala 
945                 950                 955                 960 


Asp Arg Gln Ala Phe His Met Glu Gln Leu Lys Tyr Ala Glu Met Arg 
                965                 970                 975     


Ala Arg Gln Gln His Phe Gln Gln Met His Gln Gln Gln Gln Gln Pro 
            980                 985                 990         


Pro Pro Ala Leu Pro Pro Gly Ser  Gln Pro Ile Pro Pro  Thr Gly Ala 
        995                 1000                 1005             


Ala Gly  Pro Pro Ala Val His  Gly Leu Ala Val Ala  Pro Ala Ser 
    1010                 1015                 1020             


Val Val  Pro Ala Pro Ala Gly  Ser Gly Ala Pro Pro  Gly Ser Leu 
    1025                 1030                 1035             


Gly Pro  Ser Glu Gln Ile Gly  Gln Ala Gly Ser Thr  Ala Gly Pro 
    1040                 1045                 1050             


Gln Gln  Gln Gln Pro Ala Gly  Ala Pro Gln Pro Gly  Ala Val Pro 
    1055                 1060                 1065             


Pro Gly  Val Pro Pro Pro Gly  Pro His Gly Pro Ser  Pro Phe Pro 
    1070                 1075                 1080             


Asn Gln  Gln Thr Pro Pro Ser  Met Met Pro Gly Ala  Val Pro Gly 
    1085                 1090                 1095             


Ser Gly  His Pro Gly Val Ala  Gly Asn Ala Pro Leu  Gly Leu Pro 
    1100                 1105                 1110             


Phe Gly  Met Pro Pro Pro Pro  Pro Pro Pro Ala Pro  Ser Ile Ile 
    1115                 1120                 1125             


Pro Phe  Gly Ser Leu Ala Asp  Ser Ile Ser Ile Asn  Leu Pro Ala 
    1130                 1135                 1140             


Pro Pro  Asn Leu His Gly His  His His His Leu Pro  Phe Ala Pro 
    1145                 1150                 1155             


Gly Thr  Leu Pro Pro Pro Asn  Leu Pro Val Ser Met  Ala Asn Pro 
    1160                 1165                 1170             


Leu His  Pro Asn Leu Pro Ala  Thr Thr Thr Met Pro  Ser Ser Leu 
    1175                 1180                 1185             


Pro Leu  Gly Pro Gly Leu Gly  Ser Ala Ala Ala Gln  Ser Pro Ala 
    1190                 1195                 1200             


Ile Val  Ala Ala Val Gln Gly  Asn Leu Leu Pro Ser  Ala Ser Pro 
    1205                 1210                 1215             


Leu Pro  Asp Pro Gly Thr Pro  Leu Pro Pro Asp Pro  Thr Ala Pro 
    1220                 1225                 1230             


Ser Pro  Gly Thr Val Thr Pro  Val Pro Pro Pro Gln  
    1235                 1240                 1245 


<210> 72
<211> 4964
<212> DNA
<213> Mus musculus

<400> 72
gtggcggcgg gaggcggcgg gaggcgggcg gaggaggagg cgggagctga gctgagcggg       60

gcgggcggcg gcggggcccg agcccgagaa gatggcggtg cggaagaagg acggcggccc      120

caacgtgaag tactacgagg ccgcggacac cgtgacccag ttcgacaacg tgcggctctg      180

gctcggcaag aactacaaga agtacataca agcagaaccg ccaaccaaca agtctctgtc      240

cagcctggtg gtgcagttgc tccagtttca ggaagaggtt tttggcaaac atgtcagcaa      300

cgcaccgctt actaaactgc cgatcaaatg tttcctagat ttcaaagcag gaggatccct      360

ctgccatatt cttgcagctg cctacaaatt caagagtgac cagggatggc ggcgttacga      420

tttccagaat ccatcacgca tggaccgcaa tgtggaaatg ttcatgacca ttgagaagtc      480

cttggtacag aataattgcc tgtcacgacc taacattttc ctctgcccag aaattgagcc      540

caaactgcta gggaaattaa aagacattgt taagagacac cagggaacca tctctgagga      600

taagagcaat gcctcccatg ttgtgtatcc tgtcccaggg aacctagaag aagaggaatg      660

ggtacggcca gtcatgaaga gggataaaca ggttcttctg cactggggct actatcctga      720

cagctacgac acgtggatcc cagcgagtga aattgaagca tctgtggagg acgctcccac      780

tcctgagaaa ccgaggaagg tccatgcgaa gtggatcctc gacaccgaca cattcaacga      840

gtggatgaat gaggaagact acgaagtcag tgacgacaaa agcccagtct cccgcaggaa      900

gaagatctca gccaagacgc tgacagacga ggtaaacagc ccagattcag acagacgaga      960

caagaagggg ggcaactata agaagaggaa gcgctctccc tctccttcac ccaccccaga     1020

ggctaagaag aaaaacgcta agaaaggacc ctcaacacct tataccaagt caaagcgagg     1080

ccacagagaa gaggaacaag aagacctgac aaaagacatg gatgagccct ctccagtccc     1140

aaacgtggaa gaggtgacac tccccaaaac agtcaacact aaaaaggact ctgagtcagc     1200

cccagtcaaa ggcggcacca tgactgacct ggatgaacag gacgatgaaa gcatggagac     1260

caccggcaag gacgaggatg agaacagcac gggcaacaaa ggcgagcaga cgaagaaccc     1320

ggacctgcat gaggacaatg tgaccgagca gacccaccac atcatcatcc ccagctacgc     1380

cgcctggttt gactacaaca gcgtccatgc cattgaacgg agggctcttc ctgagttctt     1440

caacggcaag aacaagtcta agactccaga gatctacctg gcgtatcgga acttcatgat     1500

tgacacttac cgactgaatc cccaggagta tctaacatct actgcctgtc ggcggaattt     1560

ggcgggtgat gtctgcgcta tcatgagggt ccatgccttc ctggaacagt ggggtcttat     1620

taactaccag gtagatgctg agagccgacc aaccccaatg gggcctccac ccacctctca     1680

cttccatgtc ttggcggaca caccatcagg gctggttcct cttcagccga agcctccaca     1740

gcagagctct gcttcccagc aaatgctgaa cttccctgag aagggcaagg agaaaccagc     1800

agacatgcag aattttgggc tgcgcacaga catgtacaca aagaagaacg tcccctccaa     1860

gagcaaagct gcagcaagtg ccactcggga atggacggag caggagactc tgctgctcct     1920

ggaggctttg gaaatgtaca aggacgactg gaacaaagta tctgagcacg tgggaagccg     1980

cacgcaggac gagtgcatct tgcattttct ccgccttccc attgaagacc catacctgga     2040

ggactcggag gcttctctag gccctctggc ctaccaaccc atccccttca gtcagtcagg     2100

caaccctgtt atgagcaccg ttgccttcct ggcctctgtc gtcgatcccc gagttgcctc     2160

tgctgctgcg aagtcagccc tagaagagtt ctcaaaaatg aaggaagagg tgcccacagc     2220

tttggtggaa gcccacgtgc gtaaggtcga agaagcggcc aaagtcacag gcaaggccga     2280

cccagccttt ggtctggaga gtagcggcat cgcagggact gcctctgatg agcctgagcg     2340

cattgaggaa agcgggactg aggaggcacg gccagagggc caggcagcag atgagaagaa     2400

ggagcctaag gaaccacggg aaggaggggg cgctgtggag gaagaagcaa aggaggaaat     2460

aagtgaggtc cccaagaaag atgaagagaa agggaaagaa ggtgacagtg agaaggagtc     2520

tgagaagagt gacggggacc cgatagttga tcctgagaaa gacaaggaac caacagaagg     2580

gcaggaggaa gtgctaaagg aagtggcaga gccagagggg gagaggaaaa ccaaggtgga     2640

gcgtgacatt ggtgaaggca acctgtccac agctgcagcc gcagccctgg ccgctgctgc     2700

agtcaaggcc aagcacttgg ctgcagttga ggagagaaag atcaagtctt tggtggctct     2760

gctggtagag acccaaatga agaaactaga gatcaaactc cgacattttg aggagctgga     2820

gacaataatg gaccgggagc gagaggcgct ggaataccag aggcagcagc tcctggccga     2880

ccggcaagcc ttccacatgg agcagctgaa gtatgcagag atgagggccc ggcagcagca     2940

cttccagcag atgcaccagc agcagcagca gcagccacca accttgcccc caggctccca     3000

gcccatacct cccaccgggg ctgctggacc acctacagtc catggtctag ctgtgcctcc     3060

agccgctgtg gcctctgccc ctcctggcag tggggcccct cctggaagct tgggcccttc     3120

tgaacagatt gggcaggcag ggacaactgc agggccacag cagccacaac aagctggagc     3180

ccctcagcct ggggcagtcc caccaggggt acccccccct ggaccccatg gcccctcacc     3240

gttccccaac caaccaactc ctccctcaat gatgccaggg gcagtgccag gcagcgggca     3300

cccaggcgtg gcgggtaatg ctcctttggg tttgcctttt ggcatgccgc ctcctcctcc     3360

tgctgctcca tccgtcatcc cattcggtag tctagctgac tccattagta ttaaccttcc     3420

ccctcctcct aacctgcatg ggcatcacca ccatctcccg tttgccccgg gcactatccc     3480

cccacctaac ctgcctgtgt ccatggcgaa ccctctacat cctaacctgc cggcgaccac     3540

caccatgcca tcttccttgc ctctcgggcc ggggctcgga tccgccgcag cccagagccc     3600

tgccattgtg gcagctgttc agggcaacct cctgcccagt gccagcccac tgccagaccc     3660

aggcaccccg ctgcctccag accccacagc tccaagccca ggcacagtca cccctgtgcc     3720

acctccacag tgaggaacca gccagccatc tctccccctc actccccatg gagatcacag     3780

ttccaggaac agccctcccc cactactggg accctccctc agcctgaaga gttcatcact     3840

acgtaaggaa agctcctcct gccccctcac cacccccacc atgcccagca gaggtgtgca     3900

gttttatatc caattattat ccacggactt ctgactaaaa gatgtttcta atgcctggga     3960

gagagaatag gagggaaaga tgtttatacg aggttctact aactggttct gagggtctac     4020

cccttcagaa ttactgcatt tttgaagtga taacatgaaa atgaaaccct ttaaaaggga     4080

ggttttaaaa aaagacactt cggagcccac aaaaaaagaa cttttttaat tattattatt     4140

attattttga ggggaaaggg caggttttaa gaggaattaa atttctgggg caaggtgtga     4200

ggtggaatag ggcaccgagc ctgtctccct gagcccttgg cagtgctgag tcagctcccc     4260

tcacccattc cagtttattc atacaaatcc ctcctgctgc tcgtcatggt tgctgtttta     4320

ggcccagttc agccaatgac cttttcctcc agtcagcttt gtgtttgtgt ttaagtcacc     4380

tgcttactcg tcagcgtctg tgtacttgtg ggaaatgtag ttttcgggga ttctgtggta     4440

ggaaatagag gaagaagggg cctcagttgg gctcttcttc ctgctttcct agttgtatct     4500

gtgagtgccc aacaggcatc agagggggag ctctaagagg atggggggcc tgcagaccct     4560

caagtttgaa aagcacttaa gcacctactt ttgacagtgg gacagtctgc taacttctgc     4620

ccccaccaac caagcctgac agaacccagt gatagctagg agttccccaa atgaggacaa     4680

agatttggga gcagtgcagc gtgcctctgc actccaggtc ttcctcttca ccccctactt     4740

ggaggcagac acaattccag gccgcaccag agcctggccc ctcccaccag gcgctttgct     4800

ccttctgtcc cagcgtctcc ttcctctgca tctccacacc tttcttctgt tcaaagtctt     4860

ctgtaaaatt ttctttcctt ctttgttctt ttctttttcc tttttttttt ataaattaat     4920

ttgctttcag ttccaaaaaa aaaaaaaaaa aaaaaaaaaa aaaa                      4964


<210> 73
<211> 1213
<212> PRT
<213> Mus musculus

<400> 73
Met Ala Val Arg Lys Lys Asp Gly Gly Pro Asn Val Lys Tyr Tyr Glu 
1               5                   10                  15      


Ala Ala Asp Thr Val Thr Gln Phe Asp Asn Val Arg Leu Trp Leu Gly 
            20                  25                  30          


Lys Asn Tyr Lys Lys Tyr Ile Gln Ala Glu Pro Pro Thr Asn Lys Ser 
        35                  40                  45              


Leu Ser Ser Leu Val Val Gln Leu Leu Gln Phe Gln Glu Glu Val Phe 
    50                  55                  60                  


Gly Lys His Val Ser Asn Ala Pro Leu Thr Lys Leu Pro Ile Lys Cys 
65                  70                  75                  80  


Phe Leu Asp Phe Lys Ala Gly Gly Ser Leu Cys His Ile Leu Ala Ala 
                85                  90                  95      


Ala Tyr Lys Phe Lys Ser Asp Gln Gly Trp Arg Arg Tyr Asp Phe Gln 
            100                 105                 110         


Asn Pro Ser Arg Met Asp Arg Asn Val Glu Met Phe Met Thr Ile Glu 
        115                 120                 125             


Lys Ser Leu Val Gln Asn Asn Cys Leu Ser Arg Pro Asn Ile Phe Leu 
    130                 135                 140                 


Cys Pro Glu Ile Glu Pro Lys Leu Leu Gly Lys Leu Lys Asp Ile Val 
145                 150                 155                 160 


Lys Arg His Gln Gly Thr Ile Ser Glu Asp Lys Ser Asn Ala Ser His 
                165                 170                 175     


Val Val Tyr Pro Val Pro Gly Asn Leu Glu Glu Glu Glu Trp Val Arg 
            180                 185                 190         


Pro Val Met Lys Arg Asp Lys Gln Val Leu Leu His Trp Gly Tyr Tyr 
        195                 200                 205             


Pro Asp Ser Tyr Asp Thr Trp Ile Pro Ala Ser Glu Ile Glu Ala Ser 
    210                 215                 220                 


Val Glu Asp Ala Pro Thr Pro Glu Lys Pro Arg Lys Val His Ala Lys 
225                 230                 235                 240 


Trp Ile Leu Asp Thr Asp Thr Phe Asn Glu Trp Met Asn Glu Glu Asp 
                245                 250                 255     


Tyr Glu Val Ser Asp Asp Lys Ser Pro Val Ser Arg Arg Lys Lys Ile 
            260                 265                 270         


Ser Ala Lys Thr Leu Thr Asp Glu Val Asn Ser Pro Asp Ser Asp Arg 
        275                 280                 285             


Arg Asp Lys Lys Gly Gly Asn Tyr Lys Lys Arg Lys Arg Ser Pro Ser 
    290                 295                 300                 


Pro Ser Pro Thr Pro Glu Ala Lys Lys Lys Asn Ala Lys Lys Gly Pro 
305                 310                 315                 320 


Ser Thr Pro Tyr Thr Lys Ser Lys Arg Gly His Arg Glu Glu Glu Gln 
                325                 330                 335     


Glu Asp Leu Thr Lys Asp Met Asp Glu Pro Ser Pro Val Pro Asn Val 
            340                 345                 350         


Glu Glu Val Thr Leu Pro Lys Thr Val Asn Thr Lys Lys Asp Ser Glu 
        355                 360                 365             


Ser Ala Pro Val Lys Gly Gly Thr Met Thr Asp Leu Asp Glu Gln Asp 
    370                 375                 380                 


Asp Glu Ser Met Glu Thr Thr Gly Lys Asp Glu Asp Glu Asn Ser Thr 
385                 390                 395                 400 


Gly Asn Lys Gly Glu Gln Thr Lys Asn Pro Asp Leu His Glu Asp Asn 
                405                 410                 415     


Val Thr Glu Gln Thr His His Ile Ile Ile Pro Ser Tyr Ala Ala Trp 
            420                 425                 430         


Phe Asp Tyr Asn Ser Val His Ala Ile Glu Arg Arg Ala Leu Pro Glu 
        435                 440                 445             


Phe Phe Asn Gly Lys Asn Lys Ser Lys Thr Pro Glu Ile Tyr Leu Ala 
    450                 455                 460                 


Tyr Arg Asn Phe Met Ile Asp Thr Tyr Arg Leu Asn Pro Gln Glu Tyr 
465                 470                 475                 480 


Leu Thr Ser Thr Ala Cys Arg Arg Asn Leu Ala Gly Asp Val Cys Ala 
                485                 490                 495     


Ile Met Arg Val His Ala Phe Leu Glu Gln Trp Gly Leu Ile Asn Tyr 
            500                 505                 510         


Gln Val Asp Ala Glu Ser Arg Pro Thr Pro Met Gly Pro Pro Pro Thr 
        515                 520                 525             


Ser His Phe His Val Leu Ala Asp Thr Pro Ser Gly Leu Val Pro Leu 
    530                 535                 540                 


Gln Pro Lys Pro Pro Gln Gln Ser Ser Ala Ser Gln Gln Met Leu Asn 
545                 550                 555                 560 


Phe Pro Glu Lys Gly Lys Glu Lys Pro Ala Asp Met Gln Asn Phe Gly 
                565                 570                 575     


Leu Arg Thr Asp Met Tyr Thr Lys Lys Asn Val Pro Ser Lys Ser Lys 
            580                 585                 590         


Ala Ala Ala Ser Ala Thr Arg Glu Trp Thr Glu Gln Glu Thr Leu Leu 
        595                 600                 605             


Leu Leu Glu Ala Leu Glu Met Tyr Lys Asp Asp Trp Asn Lys Val Ser 
    610                 615                 620                 


Glu His Val Gly Ser Arg Thr Gln Asp Glu Cys Ile Leu His Phe Leu 
625                 630                 635                 640 


Arg Leu Pro Ile Glu Asp Pro Tyr Leu Glu Asp Ser Glu Ala Ser Leu 
                645                 650                 655     


Gly Pro Leu Ala Tyr Gln Pro Ile Pro Phe Ser Gln Ser Gly Asn Pro 
            660                 665                 670         


Val Met Ser Thr Val Ala Phe Leu Ala Ser Val Val Asp Pro Arg Val 
        675                 680                 685             


Ala Ser Ala Ala Ala Lys Ser Ala Leu Glu Glu Phe Ser Lys Met Lys 
    690                 695                 700                 


Glu Glu Val Pro Thr Ala Leu Val Glu Ala His Val Arg Lys Val Glu 
705                 710                 715                 720 


Glu Ala Ala Lys Val Thr Gly Lys Ala Asp Pro Ala Phe Gly Leu Glu 
                725                 730                 735     


Ser Ser Gly Ile Ala Gly Thr Ala Ser Asp Glu Pro Glu Arg Ile Glu 
            740                 745                 750         


Glu Ser Gly Thr Glu Glu Ala Arg Pro Glu Gly Gln Ala Ala Asp Glu 
        755                 760                 765             


Lys Lys Glu Pro Lys Glu Pro Arg Glu Gly Gly Gly Ala Val Glu Glu 
    770                 775                 780                 


Glu Ala Lys Glu Glu Ile Ser Glu Val Pro Lys Lys Asp Glu Glu Lys 
785                 790                 795                 800 


Gly Lys Glu Gly Asp Ser Glu Lys Glu Ser Glu Lys Ser Asp Gly Asp 
                805                 810                 815     


Pro Ile Val Asp Pro Glu Lys Asp Lys Glu Pro Thr Glu Gly Gln Glu 
            820                 825                 830         


Glu Val Leu Lys Glu Val Ala Glu Pro Glu Gly Glu Arg Lys Thr Lys 
        835                 840                 845             


Val Glu Arg Asp Ile Gly Glu Gly Asn Leu Ser Thr Ala Ala Ala Ala 
    850                 855                 860                 


Ala Leu Ala Ala Ala Ala Val Lys Ala Lys His Leu Ala Ala Val Glu 
865                 870                 875                 880 


Glu Arg Lys Ile Lys Ser Leu Val Ala Leu Leu Val Glu Thr Gln Met 
                885                 890                 895     


Lys Lys Leu Glu Ile Lys Leu Arg His Phe Glu Glu Leu Glu Thr Ile 
            900                 905                 910         


Met Asp Arg Glu Arg Glu Ala Leu Glu Tyr Gln Arg Gln Gln Leu Leu 
        915                 920                 925             


Ala Asp Arg Gln Ala Phe His Met Glu Gln Leu Lys Tyr Ala Glu Met 
    930                 935                 940                 


Arg Ala Arg Gln Gln His Phe Gln Gln Met His Gln Gln Gln Gln Gln 
945                 950                 955                 960 


Gln Pro Pro Thr Leu Pro Pro Gly Ser Gln Pro Ile Pro Pro Thr Gly 
                965                 970                 975     


Ala Ala Gly Pro Pro Thr Val His Gly Leu Ala Val Pro Pro Ala Ala 
            980                 985                 990         


Val Ala Ser Ala Pro Pro Gly Ser  Gly Ala Pro Pro Gly  Ser Leu Gly 
        995                 1000                 1005             


Pro Ser  Glu Gln Ile Gly Gln  Ala Gly Thr Thr Ala  Gly Pro Gln 
    1010                 1015                 1020             


Gln Pro  Gln Gln Ala Gly Ala  Pro Gln Pro Gly Ala  Val Pro Pro 
    1025                 1030                 1035             


Gly Val  Pro Pro Pro Gly Pro  His Gly Pro Ser Pro  Phe Pro Asn 
    1040                 1045                 1050             


Gln Pro  Thr Pro Pro Ser Met  Met Pro Gly Ala Val  Pro Gly Ser 
    1055                 1060                 1065             


Gly His  Pro Gly Val Ala Gly  Asn Ala Pro Leu Gly  Leu Pro Phe 
    1070                 1075                 1080             


Gly Met  Pro Pro Pro Pro Pro  Ala Ala Pro Ser Val  Ile Pro Phe 
    1085                 1090                 1095             


Gly Ser  Leu Ala Asp Ser Ile  Ser Ile Asn Leu Pro  Pro Pro Pro 
    1100                 1105                 1110             


Asn Leu  His Gly His His His  His Leu Pro Phe Ala  Pro Gly Thr 
    1115                 1120                 1125             


Ile Pro  Pro Pro Asn Leu Pro  Val Ser Met Ala Asn  Pro Leu His 
    1130                 1135                 1140             


Pro Asn  Leu Pro Ala Thr Thr  Thr Met Pro Ser Ser  Leu Pro Leu 
    1145                 1150                 1155             


Gly Pro  Gly Leu Gly Ser Ala  Ala Ala Gln Ser Pro  Ala Ile Val 
    1160                 1165                 1170             


Ala Ala  Val Gln Gly Asn Leu  Leu Pro Ser Ala Ser  Pro Leu Pro 
    1175                 1180                 1185             


Asp Pro  Gly Thr Pro Leu Pro  Pro Asp Pro Thr Ala  Pro Ser Pro 
    1190                 1195                 1200             


Gly Thr  Val Thr Pro Val Pro  Pro Pro Gln 
    1205                 1210             


<210> 74
<211> 4715
<212> DNA
<213> Mus musculus

<400> 74
gtggcggcgg gaggcggcgg gaggcgggcg gaggaggagg cgggagctga gctgagcggg       60

gcgggcggcg gcggggcccg agcccgagaa gatggcggtg cggaagaagg acggcggccc      120

caacgtgaag tactacgagg ccgcggacac cgtgacccag ttcgacaacg tgcggctctg      180

gctcggcaag aactacaaga agtacataca agcagaaccg ccaaccaaca agtctctgtc      240

cagcctggtg gtgcagttgc tccagtttca ggaagaggtt tttggcaaac atgtcagcaa      300

cgcaccgctt actaaactgc cgatcaaatg tttcctagat ttcaaagcag gaggatccct      360

ctgccatatt cttgcagctg cctacaaatt caagagtgac cagggatggc ggcgttacga      420

tttccagaat ccatcacgca tggaccgcaa tgtggaaatg ttcatgacca ttgagaagtc      480

cttggtacag aataattgcc tgtcacgacc taacattttc ctctgcccag aaattgagcc      540

caaactgcta gggaaattaa aagacattgt taagagacac cagggaacca tctctgagga      600

taagagcaat gcctcccatg ttgtgtatcc tgtcccaggg aacctagaag aagaggaatg      660

ggtacggcca gtcatgaaga gggataaaca ggttcttctg cactggggct actatcctga      720

cagctacgac acgtggatcc cagcgagtga aattgaagca tctgtggagg acgctcccac      780

tcctgagaaa ccgaggaagg tccatgcgaa gtggatcctc gacaccgaca cattcaacga      840

gtggatgaat gaggaagact acgaagtcag tgacgacaaa agcccagtct cccgcaggaa      900

gaagatctca gccaagacgc tgacagacga ggtaaacagc ccagattcag acagacgaga      960

caagaagggg ggcaactata agaagaggaa gcgctctccc tctccttcac ccaccccaga     1020

ggctaagaag aaaaacgcta agaaaggacc ctcaacacct tataccaagt caaagcgagg     1080

ccacagagaa gaggaacaag aagacctgac aaaagacatg gatgagccct ctccagtccc     1140

aaacgtggaa gaggtgacac tccccaaaac agtcaacact aaaaaggact ctgagtcagc     1200

cccagtcaaa ggcggcacca tgactgacct ggatgaacag gacgatgaaa gcatggagac     1260

caccggcaag gacgaggatg agaacagcac gggcaacaaa ggcgagcaga cgaagaaccc     1320

ggacctgcat gaggacaatg tgaccgagca gacccaccac atcatcatcc ccagctacgc     1380

cgcctggttt gactacaaca gcgtccatgc cattgaacgg agggctcttc ctgagttctt     1440

caacggcaag aacaagtcta agactccaga gatctacctg gcgtatcgga acttcatgat     1500

tgacacttac cgactgaatc cccaggagta tctaacatct actgcctgtc ggcggaattt     1560

ggcgggtgat gtctgcgcta tcatgagggt ccatgccttc ctggaacagt ggggtcttat     1620

taactaccag gtagatgctg agagccgacc aaccccaatg gggcctccac ccacctctca     1680

cttccatgtc ttggcggaca caccatcagg gctggttcct cttcagccga agcctccaca     1740

gggccgccag gttgatgctg acaccaaggc tgggcggaag ggcaaagagc tggatgacct     1800

ggtgccagag acggctaagg gcaagccaga gctgcagagc tctgcttccc agcaaatgct     1860

gaacttccct gagaagggca aggagaaacc agcagacatg cagaattttg ggctgcgcac     1920

agacatgtac acaaagaaga acgtcccctc caagagcaaa gctgcagcaa gtgccactcg     1980

ggaatggacg gagcaggaga ctctgctgct cctggaggct ttggaaatgt acaaggacga     2040

ctggaacaaa gtatctgagc acgtgggaag ccgcacgcag gacgagtgca tcttgcattt     2100

tctccgcctt cccattgaag acccatacct ggaggactcg gaggcttctc taggccctct     2160

ggcctaccaa cccatcccct tcagtcagtc aggcaaccct gttatgagca ccgttgcctt     2220

cctggcctct gtcgtcgatc cccgagttgc ctctgctgct gcgaagtcag ccctagaaga     2280

gttctcaaaa atgaaggaag aggtgcccac agctttggtg gaagcccacg tgcgtaaggt     2340

cgaagaagcg gccaaagtca caggcaaggc cgacccagcc tttggtctgg agagtagcgg     2400

catcgcaggg actgcctctg atgagcctga gcgcattgag gaaagcggga ctgaggaggc     2460

acggccagag ggccaggcag cagatgagaa gaaggagcct aaggaaccac gggaaggagg     2520

gggcgctgtg gaggaagaag caaaggagga aataagtgag gtccccaaga aagatgaaga     2580

gaaagggaaa gaaggtgaca gtgagaagga gtctgagaag agtgacgggg acccgatagt     2640

tgatcctgag aaagacaagg aaccaacaga agggcaggag gaagtgctaa aggaagtggc     2700

agagccagag ggggagagga aaaccaaggt ggagcgtgac attggtgaag gcaacctgtc     2760

cacagctgca gccgcagccc tggccgctgc tgcagtcaag gccaagcact tggctgcagt     2820

tgaggagaga aagatcaagt ctttggtggc tctgctggta gagacccaaa tgaagaaact     2880

agagatcaaa ctccgacatt ttgaggagct ggagacaata atggaccggg agcgagaggc     2940

gctggaatac cagaggcagc agctcctggc cgaccggcaa gccttccaca tggagcagct     3000

gaagtatgca gagatgaggg cccggcagca gcacttccag cagatgcacc agcagcagca     3060

gcagcagcca ccaaccttgc ccccaggctc ccagcccata cctcccaccg gggctgctgg     3120

accacctaca gtccatggtc tagctgtgcc tccagccgct gtggcctctg cccctcctgg     3180

cagtggggcc cctcctggaa gcttgggccc ttctgaacag attgggcagg cagggacaac     3240

tgcagggcca cagcagccac aacaagctgg agcccctcag cctggggcag tcccaccagg     3300

ggtacccccc cctggacccc atggcccctc accgttcccc aaccaaccaa ctcctccctc     3360

aatgatgcca ggggcagtgc caggcagcgg gcacccaggc gtggcggacc caggcacccc     3420

gctgcctcca gaccccacag ctccaagccc aggcacagtc acccctgtgc cacctccaca     3480

gtgaggaacc agccagccat ctctccccct cactccccat ggagatcaca gttccaggaa     3540

cagccctccc ccactactgg gaccctccct cagcctgaag agttcatcac tacgtaagga     3600

aagctcctcc tgccccctca ccacccccac catgcccagc agaggtgtgc agttttatat     3660

ccaattatta tccacggact tctgactaaa agatgtttct aatgcctggg agagagaata     3720

ggagggaaag atgtttatac gaggttctac taactggttc tgagggtcta ccccttcaga     3780

attactgcat ttttgaagtg ataacatgaa aatgaaaccc tttaaaaggg aggttttaaa     3840

aaaagacact tcggagccca caaaaaaaga acttttttaa ttattattat tattattttg     3900

aggggaaagg gcaggtttta agaggaatta aatttctggg gcaaggtgtg aggtggaata     3960

gggcaccgag cctgtctccc tgagcccttg gcagtgctga gtcagctccc ctcacccatt     4020

ccagtttatt catacaaatc cctcctgctg ctcgtcatgg ttgctgtttt aggcccagtt     4080

cagccaatga ccttttcctc cagtcagctt tgtgtttgtg tttaagtcac ctgcttactc     4140

gtcagcgtct gtgtacttgt gggaaatgta gttttcgggg attctgtggt aggaaataga     4200

ggaagaaggg gcctcagttg ggctcttctt cctgctttcc tagttgtatc tgtgagtgcc     4260

caacaggcat cagaggggga gctctaagag gatggggggc ctgcagaccc tcaagtttga     4320

aaagcactta agcacctact tttgacagtg ggacagtctg ctaacttctg cccccaccaa     4380

ccaagcctga cagaacccag tgatagctag gagttcccca aatgaggaca aagatttggg     4440

agcagtgcag cgtgcctctg cactccaggt cttcctcttc accccctact tggaggcaga     4500

cacaattcca ggccgcacca gagcctggcc cctcccacca ggcgctttgc tccttctgtc     4560

ccagcgtctc cttcctctgc atctccacac ctttcttctg ttcaaagtct tctgtaaaat     4620

tttctttcct tctttgttct tttctttttc cttttttttt tataaattaa tttgctttca     4680

gttccaaaaa aaaaaaaaaa aaaaaaaaaa aaaaa                                4715


<210> 75
<211> 1130
<212> PRT
<213> Mus musculus

<400> 75
Met Ala Val Arg Lys Lys Asp Gly Gly Pro Asn Val Lys Tyr Tyr Glu 
1               5                   10                  15      


Ala Ala Asp Thr Val Thr Gln Phe Asp Asn Val Arg Leu Trp Leu Gly 
            20                  25                  30          


Lys Asn Tyr Lys Lys Tyr Ile Gln Ala Glu Pro Pro Thr Asn Lys Ser 
        35                  40                  45              


Leu Ser Ser Leu Val Val Gln Leu Leu Gln Phe Gln Glu Glu Val Phe 
    50                  55                  60                  


Gly Lys His Val Ser Asn Ala Pro Leu Thr Lys Leu Pro Ile Lys Cys 
65                  70                  75                  80  


Phe Leu Asp Phe Lys Ala Gly Gly Ser Leu Cys His Ile Leu Ala Ala 
                85                  90                  95      


Ala Tyr Lys Phe Lys Ser Asp Gln Gly Trp Arg Arg Tyr Asp Phe Gln 
            100                 105                 110         


Asn Pro Ser Arg Met Asp Arg Asn Val Glu Met Phe Met Thr Ile Glu 
        115                 120                 125             


Lys Ser Leu Val Gln Asn Asn Cys Leu Ser Arg Pro Asn Ile Phe Leu 
    130                 135                 140                 


Cys Pro Glu Ile Glu Pro Lys Leu Leu Gly Lys Leu Lys Asp Ile Val 
145                 150                 155                 160 


Lys Arg His Gln Gly Thr Ile Ser Glu Asp Lys Ser Asn Ala Ser His 
                165                 170                 175     


Val Val Tyr Pro Val Pro Gly Asn Leu Glu Glu Glu Glu Trp Val Arg 
            180                 185                 190         


Pro Val Met Lys Arg Asp Lys Gln Val Leu Leu His Trp Gly Tyr Tyr 
        195                 200                 205             


Pro Asp Ser Tyr Asp Thr Trp Ile Pro Ala Ser Glu Ile Glu Ala Ser 
    210                 215                 220                 


Val Glu Asp Ala Pro Thr Pro Glu Lys Pro Arg Lys Val His Ala Lys 
225                 230                 235                 240 


Trp Ile Leu Asp Thr Asp Thr Phe Asn Glu Trp Met Asn Glu Glu Asp 
                245                 250                 255     


Tyr Glu Val Ser Asp Asp Lys Ser Pro Val Ser Arg Arg Lys Lys Ile 
            260                 265                 270         


Ser Ala Lys Thr Leu Thr Asp Glu Val Asn Ser Pro Asp Ser Asp Arg 
        275                 280                 285             


Arg Asp Lys Lys Gly Gly Asn Tyr Lys Lys Arg Lys Arg Ser Pro Ser 
    290                 295                 300                 


Pro Ser Pro Thr Pro Glu Ala Lys Lys Lys Asn Ala Lys Lys Gly Pro 
305                 310                 315                 320 


Ser Thr Pro Tyr Thr Lys Ser Lys Arg Gly His Arg Glu Glu Glu Gln 
                325                 330                 335     


Glu Asp Leu Thr Lys Asp Met Asp Glu Pro Ser Pro Val Pro Asn Val 
            340                 345                 350         


Glu Glu Val Thr Leu Pro Lys Thr Val Asn Thr Lys Lys Asp Ser Glu 
        355                 360                 365             


Ser Ala Pro Val Lys Gly Gly Thr Met Thr Asp Leu Asp Glu Gln Asp 
    370                 375                 380                 


Asp Glu Ser Met Glu Thr Thr Gly Lys Asp Glu Asp Glu Asn Ser Thr 
385                 390                 395                 400 


Gly Asn Lys Gly Glu Gln Thr Lys Asn Pro Asp Leu His Glu Asp Asn 
                405                 410                 415     


Val Thr Glu Gln Thr His His Ile Ile Ile Pro Ser Tyr Ala Ala Trp 
            420                 425                 430         


Phe Asp Tyr Asn Ser Val His Ala Ile Glu Arg Arg Ala Leu Pro Glu 
        435                 440                 445             


Phe Phe Asn Gly Lys Asn Lys Ser Lys Thr Pro Glu Ile Tyr Leu Ala 
    450                 455                 460                 


Tyr Arg Asn Phe Met Ile Asp Thr Tyr Arg Leu Asn Pro Gln Glu Tyr 
465                 470                 475                 480 


Leu Thr Ser Thr Ala Cys Arg Arg Asn Leu Ala Gly Asp Val Cys Ala 
                485                 490                 495     


Ile Met Arg Val His Ala Phe Leu Glu Gln Trp Gly Leu Ile Asn Tyr 
            500                 505                 510         


Gln Val Asp Ala Glu Ser Arg Pro Thr Pro Met Gly Pro Pro Pro Thr 
        515                 520                 525             


Ser His Phe His Val Leu Ala Asp Thr Pro Ser Gly Leu Val Pro Leu 
    530                 535                 540                 


Gln Pro Lys Pro Pro Gln Gly Arg Gln Val Asp Ala Asp Thr Lys Ala 
545                 550                 555                 560 


Gly Arg Lys Gly Lys Glu Leu Asp Asp Leu Val Pro Glu Thr Ala Lys 
                565                 570                 575     


Gly Lys Pro Glu Leu Gln Ser Ser Ala Ser Gln Gln Met Leu Asn Phe 
            580                 585                 590         


Pro Glu Lys Gly Lys Glu Lys Pro Ala Asp Met Gln Asn Phe Gly Leu 
        595                 600                 605             


Arg Thr Asp Met Tyr Thr Lys Lys Asn Val Pro Ser Lys Ser Lys Ala 
    610                 615                 620                 


Ala Ala Ser Ala Thr Arg Glu Trp Thr Glu Gln Glu Thr Leu Leu Leu 
625                 630                 635                 640 


Leu Glu Ala Leu Glu Met Tyr Lys Asp Asp Trp Asn Lys Val Ser Glu 
                645                 650                 655     


His Val Gly Ser Arg Thr Gln Asp Glu Cys Ile Leu His Phe Leu Arg 
            660                 665                 670         


Leu Pro Ile Glu Asp Pro Tyr Leu Glu Asp Ser Glu Ala Ser Leu Gly 
        675                 680                 685             


Pro Leu Ala Tyr Gln Pro Ile Pro Phe Ser Gln Ser Gly Asn Pro Val 
    690                 695                 700                 


Met Ser Thr Val Ala Phe Leu Ala Ser Val Val Asp Pro Arg Val Ala 
705                 710                 715                 720 


Ser Ala Ala Ala Lys Ser Ala Leu Glu Glu Phe Ser Lys Met Lys Glu 
                725                 730                 735     


Glu Val Pro Thr Ala Leu Val Glu Ala His Val Arg Lys Val Glu Glu 
            740                 745                 750         


Ala Ala Lys Val Thr Gly Lys Ala Asp Pro Ala Phe Gly Leu Glu Ser 
        755                 760                 765             


Ser Gly Ile Ala Gly Thr Ala Ser Asp Glu Pro Glu Arg Ile Glu Glu 
    770                 775                 780                 


Ser Gly Thr Glu Glu Ala Arg Pro Glu Gly Gln Ala Ala Asp Glu Lys 
785                 790                 795                 800 


Lys Glu Pro Lys Glu Pro Arg Glu Gly Gly Gly Ala Val Glu Glu Glu 
                805                 810                 815     


Ala Lys Glu Glu Ile Ser Glu Val Pro Lys Lys Asp Glu Glu Lys Gly 
            820                 825                 830         


Lys Glu Gly Asp Ser Glu Lys Glu Ser Glu Lys Ser Asp Gly Asp Pro 
        835                 840                 845             


Ile Val Asp Pro Glu Lys Asp Lys Glu Pro Thr Glu Gly Gln Glu Glu 
    850                 855                 860                 


Val Leu Lys Glu Val Ala Glu Pro Glu Gly Glu Arg Lys Thr Lys Val 
865                 870                 875                 880 


Glu Arg Asp Ile Gly Glu Gly Asn Leu Ser Thr Ala Ala Ala Ala Ala 
                885                 890                 895     


Leu Ala Ala Ala Ala Val Lys Ala Lys His Leu Ala Ala Val Glu Glu 
            900                 905                 910         


Arg Lys Ile Lys Ser Leu Val Ala Leu Leu Val Glu Thr Gln Met Lys 
        915                 920                 925             


Lys Leu Glu Ile Lys Leu Arg His Phe Glu Glu Leu Glu Thr Ile Met 
    930                 935                 940                 


Asp Arg Glu Arg Glu Ala Leu Glu Tyr Gln Arg Gln Gln Leu Leu Ala 
945                 950                 955                 960 


Asp Arg Gln Ala Phe His Met Glu Gln Leu Lys Tyr Ala Glu Met Arg 
                965                 970                 975     


Ala Arg Gln Gln His Phe Gln Gln Met His Gln Gln Gln Gln Gln Gln 
            980                 985                 990         


Pro Pro Thr Leu Pro Pro Gly Ser  Gln Pro Ile Pro Pro  Thr Gly Ala 
        995                 1000                 1005             


Ala Gly  Pro Pro Thr Val His  Gly Leu Ala Val Pro  Pro Ala Ala 
    1010                 1015                 1020             


Val Ala  Ser Ala Pro Pro Gly  Ser Gly Ala Pro Pro  Gly Ser Leu 
    1025                 1030                 1035             


Gly Pro  Ser Glu Gln Ile Gly  Gln Ala Gly Thr Thr  Ala Gly Pro 
    1040                 1045                 1050             


Gln Gln  Pro Gln Gln Ala Gly  Ala Pro Gln Pro Gly  Ala Val Pro 
    1055                 1060                 1065             


Pro Gly  Val Pro Pro Pro Gly  Pro His Gly Pro Ser  Pro Phe Pro 
    1070                 1075                 1080             


Asn Gln  Pro Thr Pro Pro Ser  Met Met Pro Gly Ala  Val Pro Gly 
    1085                 1090                 1095             


Ser Gly  His Pro Gly Val Ala  Asp Pro Gly Thr Pro  Leu Pro Pro 
    1100                 1105                 1110             


Asp Pro  Thr Ala Pro Ser Pro  Gly Thr Val Thr Pro  Val Pro Pro 
    1115                 1120                 1125             


Pro Gln  
    1130 


<210> 76
<211> 4622
<212> DNA
<213> Mus musculus

<400> 76
gtggcggcgg gaggcggcgg gaggcgggcg gaggaggagg cgggagctga gctgagcggg       60

gcgggcggcg gcggggcccg agcccgagaa gatggcggtg cggaagaagg acggcggccc      120

caacgtgaag tactacgagg ccgcggacac cgtgacccag ttcgacaacg tgcggctctg      180

gctcggcaag aactacaaga agtacataca agcagaaccg ccaaccaaca agtctctgtc      240

cagcctggtg gtgcagttgc tccagtttca ggaagaggtt tttggcaaac atgtcagcaa      300

cgcaccgctt actaaactgc cgatcaaatg tttcctagat ttcaaagcag gaggatccct      360

ctgccatatt cttgcagctg cctacaaatt caagagtgac cagggatggc ggcgttacga      420

tttccagaat ccatcacgca tggaccgcaa tgtggaaatg ttcatgacca ttgagaagtc      480

cttggtacag aataattgcc tgtcacgacc taacattttc ctctgcccag aaattgagcc      540

caaactgcta gggaaattaa aagacattgt taagagacac cagggaacca tctctgagga      600

taagagcaat gcctcccatg ttgtgtatcc tgtcccaggg aacctagaag aagaggaatg      660

ggtacggcca gtcatgaaga gggataaaca ggttcttctg cactggggct actatcctga      720

cagctacgac acgtggatcc cagcgagtga aattgaagca tctgtggagg acgctcccac      780

tcctgagaaa ccgaggaagg tccatgcgaa gtggatcctc gacaccgaca cattcaacga      840

gtggatgaat gaggaagact acgaagtcag tgacgacaaa agcccagtct cccgcaggaa      900

gaagatctca gccaagacgc tgacagacga ggtaaacagc ccagattcag acagacgaga      960

caagaagggg ggcaactata agaagaggaa gcgctctccc tctccttcac ccaccccaga     1020

ggctaagaag aaaaacgcta agaaaggacc ctcaacacct tataccaagt caaagcgagg     1080

ccacagagaa gaggaacaag aagacctgac aaaagacatg gatgagccct ctccagtccc     1140

aaacgtggaa gaggtgacac tccccaaaac agtcaacact aaaaaggact ctgagtcagc     1200

cccagtcaaa ggcggcacca tgactgacct ggatgaacag gacgatgaaa gcatggagac     1260

caccggcaag gacgaggatg agaacagcac gggcaacaaa ggcgagcaga cgaagaaccc     1320

ggacctgcat gaggacaatg tgaccgagca gacccaccac atcatcatcc ccagctacgc     1380

cgcctggttt gactacaaca gcgtccatgc cattgaacgg agggctcttc ctgagttctt     1440

caacggcaag aacaagtcta agactccaga gatctacctg gcgtatcgga acttcatgat     1500

tgacacttac cgactgaatc cccaggagta tctaacatct actgcctgtc ggcggaattt     1560

ggcgggtgat gtctgcgcta tcatgagggt ccatgccttc ctggaacagt ggggtcttat     1620

taactaccag gtagatgctg agagccgacc aaccccaatg gggcctccac ccacctctca     1680

cttccatgtc ttggcggaca caccatcagg gctggttcct cttcagccga agcctccaca     1740

gcagagctct gcttcccagc aaatgctgaa cttccctgag aagggcaagg agaaaccagc     1800

agacatgcag aattttgggc tgcgcacaga catgtacaca aagaagaacg tcccctccaa     1860

gagcaaagct gcagcaagtg ccactcggga atggacggag caggagactc tgctgctcct     1920

ggaggctttg gaaatgtaca aggacgactg gaacaaagta tctgagcacg tgggaagccg     1980

cacgcaggac gagtgcatct tgcattttct ccgccttccc attgaagacc catacctgga     2040

ggactcggag gcttctctag gccctctggc ctaccaaccc atccccttca gtcagtcagg     2100

caaccctgtt atgagcaccg ttgccttcct ggcctctgtc gtcgatcccc gagttgcctc     2160

tgctgctgcg aagtcagccc tagaagagtt ctcaaaaatg aaggaagagg tgcccacagc     2220

tttggtggaa gcccacgtgc gtaaggtcga agaagcggcc aaagtcacag gcaaggccga     2280

cccagccttt ggtctggaga gtagcggcat cgcagggact gcctctgatg agcctgagcg     2340

cattgaggaa agcgggactg aggaggcacg gccagagggc caggcagcag atgagaagaa     2400

ggagcctaag gaaccacggg aaggaggggg cgctgtggag gaagaagcaa aggaggaaat     2460

aagtgaggtc cccaagaaag atgaagagaa agggaaagaa ggtgacagtg agaaggagtc     2520

tgagaagagt gacggggacc cgatagttga tcctgagaaa gacaaggaac caacagaagg     2580

gcaggaggaa gtgctaaagg aagtggcaga gccagagggg gagaggaaaa ccaaggtgga     2640

gcgtgacatt ggtgaaggca acctgtccac agctgcagcc gcagccctgg ccgctgctgc     2700

agtcaaggcc aagcacttgg ctgcagttga ggagagaaag atcaagtctt tggtggctct     2760

gctggtagag acccaaatga agaaactaga gatcaaactc cgacattttg aggagctgga     2820

gacaataatg gaccgggagc gagaggcgct ggaataccag aggcagcagc tcctggccga     2880

ccggcaagcc ttccacatgg agcagctgaa gtatgcagag atgagggccc ggcagcagca     2940

cttccagcag atgcaccagc agcagcagca gcagccacca accttgcccc caggctccca     3000

gcccatacct cccaccgggg ctgctggacc acctacagtc catggtctag ctgtgcctcc     3060

agccgctgtg gcctctgccc ctcctggcag tggggcccct cctggaagct tgggcccttc     3120

tgaacagatt gggcaggcag ggacaactgc agggccacag cagccacaac aagctggagc     3180

ccctcagcct ggggcagtcc caccaggggt acccccccct ggaccccatg gcccctcacc     3240

gttccccaac caaccaactc ctccctcaat gatgccaggg gcagtgccag gcagcgggca     3300

cccaggcgtg gcggacccag gcaccccgct gcctccagac cccacagctc caagcccagg     3360

cacagtcacc cctgtgccac ctccacagtg aggaaccagc cagccatctc tccccctcac     3420

tccccatgga gatcacagtt ccaggaacag ccctccccca ctactgggac cctccctcag     3480

cctgaagagt tcatcactac gtaaggaaag ctcctcctgc cccctcacca cccccaccat     3540

gcccagcaga ggtgtgcagt tttatatcca attattatcc acggacttct gactaaaaga     3600

tgtttctaat gcctgggaga gagaatagga gggaaagatg tttatacgag gttctactaa     3660

ctggttctga gggtctaccc cttcagaatt actgcatttt tgaagtgata acatgaaaat     3720

gaaacccttt aaaagggagg ttttaaaaaa agacacttcg gagcccacaa aaaaagaact     3780

tttttaatta ttattattat tattttgagg ggaaagggca ggttttaaga ggaattaaat     3840

ttctggggca aggtgtgagg tggaataggg caccgagcct gtctccctga gcccttggca     3900

gtgctgagtc agctcccctc acccattcca gtttattcat acaaatccct cctgctgctc     3960

gtcatggttg ctgttttagg cccagttcag ccaatgacct tttcctccag tcagctttgt     4020

gtttgtgttt aagtcacctg cttactcgtc agcgtctgtg tacttgtggg aaatgtagtt     4080

ttcggggatt ctgtggtagg aaatagagga agaaggggcc tcagttgggc tcttcttcct     4140

gctttcctag ttgtatctgt gagtgcccaa caggcatcag agggggagct ctaagaggat     4200

ggggggcctg cagaccctca agtttgaaaa gcacttaagc acctactttt gacagtggga     4260

cagtctgcta acttctgccc ccaccaacca agcctgacag aacccagtga tagctaggag     4320

ttccccaaat gaggacaaag atttgggagc agtgcagcgt gcctctgcac tccaggtctt     4380

cctcttcacc ccctacttgg aggcagacac aattccaggc cgcaccagag cctggcccct     4440

cccaccaggc gctttgctcc ttctgtccca gcgtctcctt cctctgcatc tccacacctt     4500

tcttctgttc aaagtcttct gtaaaatttt ctttccttct ttgttctttt ctttttcctt     4560

ttttttttat aaattaattt gctttcagtt ccaaaaaaaa aaaaaaaaaa aaaaaaaaaa     4620

aa                                                                    4622


<210> 77
<211> 1099
<212> PRT
<213> Mus musculus

<400> 77
Met Ala Val Arg Lys Lys Asp Gly Gly Pro Asn Val Lys Tyr Tyr Glu 
1               5                   10                  15      


Ala Ala Asp Thr Val Thr Gln Phe Asp Asn Val Arg Leu Trp Leu Gly 
            20                  25                  30          


Lys Asn Tyr Lys Lys Tyr Ile Gln Ala Glu Pro Pro Thr Asn Lys Ser 
        35                  40                  45              


Leu Ser Ser Leu Val Val Gln Leu Leu Gln Phe Gln Glu Glu Val Phe 
    50                  55                  60                  


Gly Lys His Val Ser Asn Ala Pro Leu Thr Lys Leu Pro Ile Lys Cys 
65                  70                  75                  80  


Phe Leu Asp Phe Lys Ala Gly Gly Ser Leu Cys His Ile Leu Ala Ala 
                85                  90                  95      


Ala Tyr Lys Phe Lys Ser Asp Gln Gly Trp Arg Arg Tyr Asp Phe Gln 
            100                 105                 110         


Asn Pro Ser Arg Met Asp Arg Asn Val Glu Met Phe Met Thr Ile Glu 
        115                 120                 125             


Lys Ser Leu Val Gln Asn Asn Cys Leu Ser Arg Pro Asn Ile Phe Leu 
    130                 135                 140                 


Cys Pro Glu Ile Glu Pro Lys Leu Leu Gly Lys Leu Lys Asp Ile Val 
145                 150                 155                 160 


Lys Arg His Gln Gly Thr Ile Ser Glu Asp Lys Ser Asn Ala Ser His 
                165                 170                 175     


Val Val Tyr Pro Val Pro Gly Asn Leu Glu Glu Glu Glu Trp Val Arg 
            180                 185                 190         


Pro Val Met Lys Arg Asp Lys Gln Val Leu Leu His Trp Gly Tyr Tyr 
        195                 200                 205             


Pro Asp Ser Tyr Asp Thr Trp Ile Pro Ala Ser Glu Ile Glu Ala Ser 
    210                 215                 220                 


Val Glu Asp Ala Pro Thr Pro Glu Lys Pro Arg Lys Val His Ala Lys 
225                 230                 235                 240 


Trp Ile Leu Asp Thr Asp Thr Phe Asn Glu Trp Met Asn Glu Glu Asp 
                245                 250                 255     


Tyr Glu Val Ser Asp Asp Lys Ser Pro Val Ser Arg Arg Lys Lys Ile 
            260                 265                 270         


Ser Ala Lys Thr Leu Thr Asp Glu Val Asn Ser Pro Asp Ser Asp Arg 
        275                 280                 285             


Arg Asp Lys Lys Gly Gly Asn Tyr Lys Lys Arg Lys Arg Ser Pro Ser 
    290                 295                 300                 


Pro Ser Pro Thr Pro Glu Ala Lys Lys Lys Asn Ala Lys Lys Gly Pro 
305                 310                 315                 320 


Ser Thr Pro Tyr Thr Lys Ser Lys Arg Gly His Arg Glu Glu Glu Gln 
                325                 330                 335     


Glu Asp Leu Thr Lys Asp Met Asp Glu Pro Ser Pro Val Pro Asn Val 
            340                 345                 350         


Glu Glu Val Thr Leu Pro Lys Thr Val Asn Thr Lys Lys Asp Ser Glu 
        355                 360                 365             


Ser Ala Pro Val Lys Gly Gly Thr Met Thr Asp Leu Asp Glu Gln Asp 
    370                 375                 380                 


Asp Glu Ser Met Glu Thr Thr Gly Lys Asp Glu Asp Glu Asn Ser Thr 
385                 390                 395                 400 


Gly Asn Lys Gly Glu Gln Thr Lys Asn Pro Asp Leu His Glu Asp Asn 
                405                 410                 415     


Val Thr Glu Gln Thr His His Ile Ile Ile Pro Ser Tyr Ala Ala Trp 
            420                 425                 430         


Phe Asp Tyr Asn Ser Val His Ala Ile Glu Arg Arg Ala Leu Pro Glu 
        435                 440                 445             


Phe Phe Asn Gly Lys Asn Lys Ser Lys Thr Pro Glu Ile Tyr Leu Ala 
    450                 455                 460                 


Tyr Arg Asn Phe Met Ile Asp Thr Tyr Arg Leu Asn Pro Gln Glu Tyr 
465                 470                 475                 480 


Leu Thr Ser Thr Ala Cys Arg Arg Asn Leu Ala Gly Asp Val Cys Ala 
                485                 490                 495     


Ile Met Arg Val His Ala Phe Leu Glu Gln Trp Gly Leu Ile Asn Tyr 
            500                 505                 510         


Gln Val Asp Ala Glu Ser Arg Pro Thr Pro Met Gly Pro Pro Pro Thr 
        515                 520                 525             


Ser His Phe His Val Leu Ala Asp Thr Pro Ser Gly Leu Val Pro Leu 
    530                 535                 540                 


Gln Pro Lys Pro Pro Gln Gln Ser Ser Ala Ser Gln Gln Met Leu Asn 
545                 550                 555                 560 


Phe Pro Glu Lys Gly Lys Glu Lys Pro Ala Asp Met Gln Asn Phe Gly 
                565                 570                 575     


Leu Arg Thr Asp Met Tyr Thr Lys Lys Asn Val Pro Ser Lys Ser Lys 
            580                 585                 590         


Ala Ala Ala Ser Ala Thr Arg Glu Trp Thr Glu Gln Glu Thr Leu Leu 
        595                 600                 605             


Leu Leu Glu Ala Leu Glu Met Tyr Lys Asp Asp Trp Asn Lys Val Ser 
    610                 615                 620                 


Glu His Val Gly Ser Arg Thr Gln Asp Glu Cys Ile Leu His Phe Leu 
625                 630                 635                 640 


Arg Leu Pro Ile Glu Asp Pro Tyr Leu Glu Asp Ser Glu Ala Ser Leu 
                645                 650                 655     


Gly Pro Leu Ala Tyr Gln Pro Ile Pro Phe Ser Gln Ser Gly Asn Pro 
            660                 665                 670         


Val Met Ser Thr Val Ala Phe Leu Ala Ser Val Val Asp Pro Arg Val 
        675                 680                 685             


Ala Ser Ala Ala Ala Lys Ser Ala Leu Glu Glu Phe Ser Lys Met Lys 
    690                 695                 700                 


Glu Glu Val Pro Thr Ala Leu Val Glu Ala His Val Arg Lys Val Glu 
705                 710                 715                 720 


Glu Ala Ala Lys Val Thr Gly Lys Ala Asp Pro Ala Phe Gly Leu Glu 
                725                 730                 735     


Ser Ser Gly Ile Ala Gly Thr Ala Ser Asp Glu Pro Glu Arg Ile Glu 
            740                 745                 750         


Glu Ser Gly Thr Glu Glu Ala Arg Pro Glu Gly Gln Ala Ala Asp Glu 
        755                 760                 765             


Lys Lys Glu Pro Lys Glu Pro Arg Glu Gly Gly Gly Ala Val Glu Glu 
    770                 775                 780                 


Glu Ala Lys Glu Glu Ile Ser Glu Val Pro Lys Lys Asp Glu Glu Lys 
785                 790                 795                 800 


Gly Lys Glu Gly Asp Ser Glu Lys Glu Ser Glu Lys Ser Asp Gly Asp 
                805                 810                 815     


Pro Ile Val Asp Pro Glu Lys Asp Lys Glu Pro Thr Glu Gly Gln Glu 
            820                 825                 830         


Glu Val Leu Lys Glu Val Ala Glu Pro Glu Gly Glu Arg Lys Thr Lys 
        835                 840                 845             


Val Glu Arg Asp Ile Gly Glu Gly Asn Leu Ser Thr Ala Ala Ala Ala 
    850                 855                 860                 


Ala Leu Ala Ala Ala Ala Val Lys Ala Lys His Leu Ala Ala Val Glu 
865                 870                 875                 880 


Glu Arg Lys Ile Lys Ser Leu Val Ala Leu Leu Val Glu Thr Gln Met 
                885                 890                 895     


Lys Lys Leu Glu Ile Lys Leu Arg His Phe Glu Glu Leu Glu Thr Ile 
            900                 905                 910         


Met Asp Arg Glu Arg Glu Ala Leu Glu Tyr Gln Arg Gln Gln Leu Leu 
        915                 920                 925             


Ala Asp Arg Gln Ala Phe His Met Glu Gln Leu Lys Tyr Ala Glu Met 
    930                 935                 940                 


Arg Ala Arg Gln Gln His Phe Gln Gln Met His Gln Gln Gln Gln Gln 
945                 950                 955                 960 


Gln Pro Pro Thr Leu Pro Pro Gly Ser Gln Pro Ile Pro Pro Thr Gly 
                965                 970                 975     


Ala Ala Gly Pro Pro Thr Val His Gly Leu Ala Val Pro Pro Ala Ala 
            980                 985                 990         


Val Ala Ser Ala Pro Pro Gly Ser  Gly Ala Pro Pro Gly  Ser Leu Gly 
        995                 1000                 1005             


Pro Ser  Glu Gln Ile Gly Gln  Ala Gly Thr Thr Ala  Gly Pro Gln 
    1010                 1015                 1020             


Gln Pro  Gln Gln Ala Gly Ala  Pro Gln Pro Gly Ala  Val Pro Pro 
    1025                 1030                 1035             


Gly Val  Pro Pro Pro Gly Pro  His Gly Pro Ser Pro  Phe Pro Asn 
    1040                 1045                 1050             


Gln Pro  Thr Pro Pro Ser Met  Met Pro Gly Ala Val  Pro Gly Ser 
    1055                 1060                 1065             


Gly His  Pro Gly Val Ala Asp  Pro Gly Thr Pro Leu  Pro Pro Asp 
    1070                 1075                 1080             


Pro Thr  Ala Pro Ser Pro Gly  Thr Val Thr Pro Val  Pro Pro Pro 
    1085                 1090                 1095             


Gln 
    


<210> 78
<211> 3431
<212> DNA
<213> Homo sapiens

<400> 78
agcacgcctt ttccgctagt cgccccgctc tatcccatag tctcgctgcc ctgagcctcc       60

cgtgccggcc ggccggccgg gggaacaggc gggcgctcgg ggggcgctcg gggggcgggg      120

ggagttccgg ttccggttct ttgtgcggct gcatcggcgg ctccgggaag atggcggccc      180

gggcgggttt ccagtctgtg gctccaagcg gcggcgccgg agcctcagga ggggcgggcg      240

cggctgctgc cttgggcccg ggcggaactc cggggcctcc tgtgcgaatg ggcccggctc      300

cgggtcaagg gctgtaccgc tccccgatgc ccggagcggc ctatccgaga ccaggtatgt      360

tgccaggcag ccgaatgaca cctcagggac cttccatggg accccctggc tatgggggga      420

acccttcagt ccgacctggc ctggcccagt cagggatgga tcagtcccgc aagagacctg      480

cccctcagca gatccagcag gtccagcagc aggcggtcca aaatcgaaac cacaatgcaa      540

agaaaaagaa gatggctgac aaaattctac ctcaaaggat tcgtgaactg gtaccagaat      600

cccaggccta tatggatctc ttggcttttg aaaggaaact ggaccagact atcatgagga      660

aacggctaga tatccaagag gccttgaaac gtcccatcaa gcaaaaacgg aagctgcgaa      720

ttttcatttc taacactttc aatccggcta agtcagatgc cgaggatggg gaagggacgg      780

tggcttcctg ggagcttcgg gtagaaggac ggctcctgga ggattcagcc ttgtccaaat      840

atgatgccac taaacaaaag aggaagttct cttccttttt taagtccttg gtgattgaac      900

tggacaaaga cctgtatggg ccagacaacc atctggtaga atggcacagg accgccacta      960

cccaggagac cgatggcttt caggtgaagc ggccgggaga cgtgaatgta cggtgtactg     1020

tcctactgat gctggattac cagcctcccc agtttaaatt agacccccgc ctagctcgac     1080

tcctgggcat ccatacccag actcgtccag tgatcatcca agcactgtgg caatatatta     1140

agacacataa gctccaggac cctcacgagc gggagtttgt catctgtgac aagtacctgc     1200

agcagatctt tgagtctcaa cgtatgaagt tttcagagat ccctcagcgg ctccatgcct     1260

tgcttatgcc accagaacct atcatcatta atcatgtcat cagtgttgac ccgaatgatc     1320

agaaaaagac agcttgttat gacattgatg ttgaagtgga tgacaccttg aagacccaga     1380

tgaattcttt tctgctgtcc actgccagcc aacaggagat tgctactcta gacaacaaga     1440

tccatgagac aatagaaacc atcaaccagc tgaagactca gcgggagttc atgctgagct     1500

ttgccagaga ccctcagggt ttcatcaatg actggcttca gtcccagtgc agggacctca     1560

agacaatgac tgatgtggtg ggtaacccag aggaggagcg ccgagctgag ttctacttcc     1620

agccctgggc tcaggaggct gtgtgccgat acttctactc caaggtgcag cagagacgac     1680

aagaattaga gcaagccctg ggaatccgga atacataggg cctctcccac agccctgatt     1740

cgactgcacc aattcttgat ttgggccctg tgctgcctgc ctcatagtat ctgccttggt     1800

cttgcttggg gcgttccagg ggatgctgtt ggttcaagga caacaccaga atgaagaggg     1860

tctcacaaga cacctgttat cctcttcttt caccctatct cttcccaccc ccagcttccc     1920

tttgccccac aaagttccca tgtgcctgta ccctcccctg gtctacatag gacctctaga     1980

tagtgttaga gagagaacat gtagtggtaa tgagtgcttg gaatggattg ggcctcaggc     2040

caggtggtct tcaaggggac cagctaactg atcctgccct tcagagaccc aggagttggg     2100

agctttcgct ccttctccaa gactcaggcc tgtgggcact ctataagcta gttgatcttg     2160

gctctcctga taacagaatc caatttcctt ccttccctcc acaggtttgg aacaaactct     2220

cccttcactt gttgccctgt agcactacag aaaccctggt tcttgggctc cactgagccc     2280

caggtcagtc cccagccctc tgggttggcc tgctgtcagt gcttctctca ctccttagtt     2340

ggggtccaca tcagtattgg agttttgttc tttattgctc cctcccagac actccctgtg     2400

gctgcccttt gtgattccct cagatctgcc ctaatcccgg gcatttgggt gggggaatct     2460

tgcctttccc tttcagagcc ccagggatct catctgggga actgtcattg ccagcagagg     2520

ctgttccttc ctgctgtttg gagatgtgac tcattcattc actcactcca ccctgcctct     2580

gcatccctta atggagaaac gggcctaaaa ccaaacgggt aaaaagccct gggccatccc     2640

tgtcttcctg tcccttgtct gcccagttga cacctactgg tgacttctag ggcactgagg     2700

agtgaaagcg cctagggctg gagaatagcg ctgagttggg tttgtgactc ttccctctcc     2760

ctgcctcaca ggattgtgac tccccagccc ctgccctcaa agcttcagac ccctcaggta     2820

gcagcaggac cttgtgatct tggccccttg gatctgagat ggtttttgca tctttccagg     2880

agagcctcac attcttcttc caggttgtat cacccccgag ttagcatatc ccaggctcgc     2940

agactcaaca cagcaagggt gggagacagc tgggcacaaa gggggaattc cgttcagcat     3000

gggctctaaa cccacagaac tgacaaagcc cctgcttccc caccccctcc tcaggctcct     3060

gcgagcacac ccccaccccc aaatccctcc ctgttctaca ctggggacag cagaattttc     3120

tccccgtctt ccccttcctg ccattttccc tcccttgaaa ggttgacact ggacaacctt     3180

ggggcagctg agccctggcc gcctcctggc tggaaccatg agaaggaagc tcagtacttc     3240

ccacagtgtc cctgttgata actgttttta ttaactgaat tgtttttttc atggaccaaa     3300

cttttttttg tactgtcccc ttattgatgt tacccagttt taataaaaga atcttctgaa     3360

ggatgggtcc tcctacctac tgtgagagag ctcttccctg agctcttctt ccttcaatac     3420

cattagccaa a                                                          3431


<210> 79
<211> 515
<212> PRT
<213> Homo sapiens

<400> 79
Met Ala Ala Arg Ala Gly Phe Gln Ser Val Ala Pro Ser Gly Gly Ala 
1               5                   10                  15      


Gly Ala Ser Gly Gly Ala Gly Ala Ala Ala Ala Leu Gly Pro Gly Gly 
            20                  25                  30          


Thr Pro Gly Pro Pro Val Arg Met Gly Pro Ala Pro Gly Gln Gly Leu 
        35                  40                  45              


Tyr Arg Ser Pro Met Pro Gly Ala Ala Tyr Pro Arg Pro Gly Met Leu 
    50                  55                  60                  


Pro Gly Ser Arg Met Thr Pro Gln Gly Pro Ser Met Gly Pro Pro Gly 
65                  70                  75                  80  


Tyr Gly Gly Asn Pro Ser Val Arg Pro Gly Leu Ala Gln Ser Gly Met 
                85                  90                  95      


Asp Gln Ser Arg Lys Arg Pro Ala Pro Gln Gln Ile Gln Gln Val Gln 
            100                 105                 110         


Gln Gln Ala Val Gln Asn Arg Asn His Asn Ala Lys Lys Lys Lys Met 
        115                 120                 125             


Ala Asp Lys Ile Leu Pro Gln Arg Ile Arg Glu Leu Val Pro Glu Ser 
    130                 135                 140                 


Gln Ala Tyr Met Asp Leu Leu Ala Phe Glu Arg Lys Leu Asp Gln Thr 
145                 150                 155                 160 


Ile Met Arg Lys Arg Leu Asp Ile Gln Glu Ala Leu Lys Arg Pro Ile 
                165                 170                 175     


Lys Gln Lys Arg Lys Leu Arg Ile Phe Ile Ser Asn Thr Phe Asn Pro 
            180                 185                 190         


Ala Lys Ser Asp Ala Glu Asp Gly Glu Gly Thr Val Ala Ser Trp Glu 
        195                 200                 205             


Leu Arg Val Glu Gly Arg Leu Leu Glu Asp Ser Ala Leu Ser Lys Tyr 
    210                 215                 220                 


Asp Ala Thr Lys Gln Lys Arg Lys Phe Ser Ser Phe Phe Lys Ser Leu 
225                 230                 235                 240 


Val Ile Glu Leu Asp Lys Asp Leu Tyr Gly Pro Asp Asn His Leu Val 
                245                 250                 255     


Glu Trp His Arg Thr Ala Thr Thr Gln Glu Thr Asp Gly Phe Gln Val 
            260                 265                 270         


Lys Arg Pro Gly Asp Val Asn Val Arg Cys Thr Val Leu Leu Met Leu 
        275                 280                 285             


Asp Tyr Gln Pro Pro Gln Phe Lys Leu Asp Pro Arg Leu Ala Arg Leu 
    290                 295                 300                 


Leu Gly Ile His Thr Gln Thr Arg Pro Val Ile Ile Gln Ala Leu Trp 
305                 310                 315                 320 


Gln Tyr Ile Lys Thr His Lys Leu Gln Asp Pro His Glu Arg Glu Phe 
                325                 330                 335     


Val Ile Cys Asp Lys Tyr Leu Gln Gln Ile Phe Glu Ser Gln Arg Met 
            340                 345                 350         


Lys Phe Ser Glu Ile Pro Gln Arg Leu His Ala Leu Leu Met Pro Pro 
        355                 360                 365             


Glu Pro Ile Ile Ile Asn His Val Ile Ser Val Asp Pro Asn Asp Gln 
    370                 375                 380                 


Lys Lys Thr Ala Cys Tyr Asp Ile Asp Val Glu Val Asp Asp Thr Leu 
385                 390                 395                 400 


Lys Thr Gln Met Asn Ser Phe Leu Leu Ser Thr Ala Ser Gln Gln Glu 
                405                 410                 415     


Ile Ala Thr Leu Asp Asn Lys Ile His Glu Thr Ile Glu Thr Ile Asn 
            420                 425                 430         


Gln Leu Lys Thr Gln Arg Glu Phe Met Leu Ser Phe Ala Arg Asp Pro 
        435                 440                 445             


Gln Gly Phe Ile Asn Asp Trp Leu Gln Ser Gln Cys Arg Asp Leu Lys 
    450                 455                 460                 


Thr Met Thr Asp Val Val Gly Asn Pro Glu Glu Glu Arg Arg Ala Glu 
465                 470                 475                 480 


Phe Tyr Phe Gln Pro Trp Ala Gln Glu Ala Val Cys Arg Tyr Phe Tyr 
                485                 490                 495     


Ser Lys Val Gln Gln Arg Arg Gln Glu Leu Glu Gln Ala Leu Gly Ile 
            500                 505                 510         


Arg Asn Thr 
        515 


<210> 80
<211> 3308
<212> DNA
<213> Homo sapiens

<400> 80
agcacgcctt ttccgctagt cgccccgctc tatcccatag tctcgctgcc ctgagcctcc       60

cgtgccggcc ggccggccgg gggaacaggc gggcgctcgg ggggcgctcg gggggcgggg      120

ggagttccgg ttccggttct ttgtgcggct gcatcggcgg ctccgggaag atggcggccc      180

gggcgggttt ccagtctgtg gctccaagcg gcggcgccgg agcctcagga ggggcgggcg      240

cggctgctgc cttgggcccg ggcggaactc cggggcctcc tgtgcgaatg ggcccggctc      300

cgggtcaagg gctgtaccgc tccccgatgc ccggagcggc ctatccgaga ccaggtatgt      360

tgccaggcag ccgaatgaca cctcagggac cttccatggg accccctggc tatgggggga      420

acccttcagt ccgacctggc ctggcccagt cagggatgga tcagtcccgc aagagacctg      480

cccctcagca gatccagcag gtccagcagc aggcggtcca aaatcgaaac cacaatgcaa      540

agaaaaagaa gatggctgac aaaattctac ctcaaaggat tcgtgaactg gtaccagaat      600

cccaggccta tatggatctc ttggcttttg aaaggaaact ggaccagact atcatgagga      660

aacggctaga tatccaagag gccttgaaac gtcccatcaa gcaaaaacgg aagctgcgaa      720

ttttcatttc taacactttc aatccggcta agtcagatgc cgaggatggg gaagggacgg      780

tggcttcctg ggagcttcgg gtagaaggac ggctcctgga ggattcagcc ttgtccaaat      840

atgatgccac taaacaaaag aggaagttct cttccttttt taagtccttg gtgattgaac      900

tggacaaaga cctgtatggg ccagacaacc atctggtaga atggcacagg accgccacta      960

cccaggagac cgatggcttt caggtgaagc ggccgggaga cgtgaatgta cggtgtactg     1020

tcctactgat gctggattac cagcctcccc agtttaaatt agacccccgc ctagctcgac     1080

tcctgggcat ccatacccag actcgtccag tgatcatcca agcactgtgg caatatatta     1140

agacacataa gctccaggac cctcacgagc gggagtttgt catctgtgac aagtacctgc     1200

agcagatctt tgagtctcaa cgtatgaagt tttcagagat ccctcagcgg ctccatgcct     1260

tgcttatgcc accagaacct atcatcatta atcatgtcat cagtgttgac ccgaatgatc     1320

agaaaaagac agcttgttat gacattgatg ttgaagtgga tgacaccttg aagacccaga     1380

tgaattcttt tctgctgtcc actgccagcc aacaggagat tgctactcta gacaacaaga     1440

caatgactga tgtggtgggt aacccagagg aggagcgccg agctgagttc tacttccagc     1500

cctgggctca ggaggctgtg tgccgatact tctactccaa ggtgcagcag agacgacaag     1560

aattagagca agccctggga atccggaata catagggcct ctcccacagc cctgattcga     1620

ctgcaccaat tcttgatttg ggccctgtgc tgcctgcctc atagtatctg ccttggtctt     1680

gcttggggcg ttccagggga tgctgttggt tcaaggacaa caccagaatg aagagggtct     1740

cacaagacac ctgttatcct cttctttcac cctatctctt cccaccccca gcttcccttt     1800

gccccacaaa gttcccatgt gcctgtaccc tcccctggtc tacataggac ctctagatag     1860

tgttagagag agaacatgta gtggtaatga gtgcttggaa tggattgggc ctcaggccag     1920

gtggtcttca aggggaccag ctaactgatc ctgcccttca gagacccagg agttgggagc     1980

tttcgctcct tctccaagac tcaggcctgt gggcactcta taagctagtt gatcttggct     2040

ctcctgataa cagaatccaa tttccttcct tccctccaca ggtttggaac aaactctccc     2100

ttcacttgtt gccctgtagc actacagaaa ccctggttct tgggctccac tgagccccag     2160

gtcagtcccc agccctctgg gttggcctgc tgtcagtgct tctctcactc cttagttggg     2220

gtccacatca gtattggagt tttgttcttt attgctccct cccagacact ccctgtggct     2280

gccctttgtg attccctcag atctgcccta atcccgggca tttgggtggg ggaatcttgc     2340

ctttcccttt cagagcccca gggatctcat ctggggaact gtcattgcca gcagaggctg     2400

ttccttcctg ctgtttggag atgtgactca ttcattcact cactccaccc tgcctctgca     2460

tcccttaatg gagaaacggg cctaaaacca aacgggtaaa aagccctggg ccatccctgt     2520

cttcctgtcc cttgtctgcc cagttgacac ctactggtga cttctagggc actgaggagt     2580

gaaagcgcct agggctggag aatagcgctg agttgggttt gtgactcttc cctctccctg     2640

cctcacagga ttgtgactcc ccagcccctg ccctcaaagc ttcagacccc tcaggtagca     2700

gcaggacctt gtgatcttgg ccccttggat ctgagatggt ttttgcatct ttccaggaga     2760

gcctcacatt cttcttccag gttgtatcac ccccgagtta gcatatccca ggctcgcaga     2820

ctcaacacag caagggtggg agacagctgg gcacaaaggg ggaattccgt tcagcatggg     2880

ctctaaaccc acagaactga caaagcccct gcttccccac cccctcctca ggctcctgcg     2940

agcacacccc cacccccaaa tccctccctg ttctacactg gggacagcag aattttctcc     3000

ccgtcttccc cttcctgcca ttttccctcc cttgaaaggt tgacactgga caaccttggg     3060

gcagctgagc cctggccgcc tcctggctgg aaccatgaga aggaagctca gtacttccca     3120

cagtgtccct gttgataact gtttttatta actgaattgt ttttttcatg gaccaaactt     3180

ttttttgtac tgtcccctta ttgatgttac ccagttttaa taaaagaatc ttctgaagga     3240

tgggtcctcc tacctactgt gagagagctc ttccctgagc tcttcttcct tcaataccat     3300

tagccaaa                                                              3308


<210> 81
<211> 474
<212> PRT
<213> Homo sapiens

<400> 81
Met Ala Ala Arg Ala Gly Phe Gln Ser Val Ala Pro Ser Gly Gly Ala 
1               5                   10                  15      


Gly Ala Ser Gly Gly Ala Gly Ala Ala Ala Ala Leu Gly Pro Gly Gly 
            20                  25                  30          


Thr Pro Gly Pro Pro Val Arg Met Gly Pro Ala Pro Gly Gln Gly Leu 
        35                  40                  45              


Tyr Arg Ser Pro Met Pro Gly Ala Ala Tyr Pro Arg Pro Gly Met Leu 
    50                  55                  60                  


Pro Gly Ser Arg Met Thr Pro Gln Gly Pro Ser Met Gly Pro Pro Gly 
65                  70                  75                  80  


Tyr Gly Gly Asn Pro Ser Val Arg Pro Gly Leu Ala Gln Ser Gly Met 
                85                  90                  95      


Asp Gln Ser Arg Lys Arg Pro Ala Pro Gln Gln Ile Gln Gln Val Gln 
            100                 105                 110         


Gln Gln Ala Val Gln Asn Arg Asn His Asn Ala Lys Lys Lys Lys Met 
        115                 120                 125             


Ala Asp Lys Ile Leu Pro Gln Arg Ile Arg Glu Leu Val Pro Glu Ser 
    130                 135                 140                 


Gln Ala Tyr Met Asp Leu Leu Ala Phe Glu Arg Lys Leu Asp Gln Thr 
145                 150                 155                 160 


Ile Met Arg Lys Arg Leu Asp Ile Gln Glu Ala Leu Lys Arg Pro Ile 
                165                 170                 175     


Lys Gln Lys Arg Lys Leu Arg Ile Phe Ile Ser Asn Thr Phe Asn Pro 
            180                 185                 190         


Ala Lys Ser Asp Ala Glu Asp Gly Glu Gly Thr Val Ala Ser Trp Glu 
        195                 200                 205             


Leu Arg Val Glu Gly Arg Leu Leu Glu Asp Ser Ala Leu Ser Lys Tyr 
    210                 215                 220                 


Asp Ala Thr Lys Gln Lys Arg Lys Phe Ser Ser Phe Phe Lys Ser Leu 
225                 230                 235                 240 


Val Ile Glu Leu Asp Lys Asp Leu Tyr Gly Pro Asp Asn His Leu Val 
                245                 250                 255     


Glu Trp His Arg Thr Ala Thr Thr Gln Glu Thr Asp Gly Phe Gln Val 
            260                 265                 270         


Lys Arg Pro Gly Asp Val Asn Val Arg Cys Thr Val Leu Leu Met Leu 
        275                 280                 285             


Asp Tyr Gln Pro Pro Gln Phe Lys Leu Asp Pro Arg Leu Ala Arg Leu 
    290                 295                 300                 


Leu Gly Ile His Thr Gln Thr Arg Pro Val Ile Ile Gln Ala Leu Trp 
305                 310                 315                 320 


Gln Tyr Ile Lys Thr His Lys Leu Gln Asp Pro His Glu Arg Glu Phe 
                325                 330                 335     


Val Ile Cys Asp Lys Tyr Leu Gln Gln Ile Phe Glu Ser Gln Arg Met 
            340                 345                 350         


Lys Phe Ser Glu Ile Pro Gln Arg Leu His Ala Leu Leu Met Pro Pro 
        355                 360                 365             


Glu Pro Ile Ile Ile Asn His Val Ile Ser Val Asp Pro Asn Asp Gln 
    370                 375                 380                 


Lys Lys Thr Ala Cys Tyr Asp Ile Asp Val Glu Val Asp Asp Thr Leu 
385                 390                 395                 400 


Lys Thr Gln Met Asn Ser Phe Leu Leu Ser Thr Ala Ser Gln Gln Glu 
                405                 410                 415     


Ile Ala Thr Leu Asp Asn Lys Thr Met Thr Asp Val Val Gly Asn Pro 
            420                 425                 430         


Glu Glu Glu Arg Arg Ala Glu Phe Tyr Phe Gln Pro Trp Ala Gln Glu 
        435                 440                 445             


Ala Val Cys Arg Tyr Phe Tyr Ser Lys Val Gln Gln Arg Arg Gln Glu 
    450                 455                 460                 


Leu Glu Gln Ala Leu Gly Ile Arg Asn Thr 
465                 470                 


<210> 82
<211> 3153
<212> DNA
<213> Mus musculus

<400> 82
gttctttgtg cagctgcagc ggcggctccg ggaagatggc ggcccgggcg ggtttccagt       60

ctgtggctcc gagcggcggc gcgggagcct caggaggagc gggcgtggcg gctgctctgg      120

gcccgggcgg aactcccggg cctcccgtgc gaatgggccc ggcgccgggt caagggctgt      180

accgctctcc gatgcccggg gcggcctatc cgagaccagg tatgctgcca ggtagccgaa      240

tgacacctca gggaccttcc atgggacctc ctggctatgg ggggaaccct tcagtccgac      300

ctggtctggc ccagtcaggg atggaccagt cccgcaagag acctgcacct caacagatcc      360

agcaggtcca gcagcaggcg gtccaaaatc gaaatcacaa tgcaaagaaa aagaagatgg      420

ctgacaaaat cctacctcaa aggattcggg aactggtccc agaatcacag gcctacatgg      480

atctcctggc ttttgaaagg aaactggacc agactattat gaggaagcgg ctagatatcc      540

aggaggcctt gaaacgtccc atcaagcaaa aacggaagct gcgaattttc atttctaaca      600

cgttcaatcc ggctaagtcg gacgcggagg atggggaagg gacggtggct tcctgggagc      660

tccgggtaga aggccggctc ctggaggacg cggccttgtc caaatatgac gccaccaagc      720

aaaagagaaa gttctcttcc ttttttaagt ccttggtgat cgaactggac aaagacctct      780

atggcccaga caaccatctg gtagaatggc acaggaccgc cactacccag gagaccgatg      840

gcttccaggt gaagcggcca ggagatgtga atgtacggtg tactgtcctg ctgatgctgg      900

actaccagcc cccccagttt aaattagacc ctcgcctggc tcggctcttg ggcatccata      960

cccagacacg tccagtgatc atccaagcac tgtggcagta tattaaaaca cacaagctcc     1020

aggaccctca cgagcgagag tttgttctct gtgacaagta cctccagcag atctttgaat     1080

ctcagcggat gaagttctca gagatccctc agcggctcca cgccttgctt atgccaccag     1140

agcccatcat catcaatcat gtcatcagtg tggacccaaa tgaccagaaa aagaccgcgt     1200

gctatgacat tgacgtggag gtggatgaca ctctgaagac ccagatgaac tctttcctgt     1260

tgtccactgc cagccagcag gagatcgcca ctctagacaa caagatccat gagacgatag     1320

agaccatcaa ccagctgaag acccagcgag agttcatgtt gagctttgcc cgagaccctc     1380

agggtttcat caatgattgg cttcagtccc agtgcaggga cctcaagacg atgactgatg     1440

tggtgggtaa cccggaagag gagcgtcgtg ctgagttcta cttccagccc tgggctcagg     1500

aggctgtgtg ccgatacttc tactccaagg tgcagcagag gcggcaagag ttagagcaag     1560

ccctgggaat ccgaaacaca tagggcctct gtggccctag cctggctgca ccgattcctt     1620

gggccctgtg ctgcctgcct cagtgtacct gtcttggtct tgcttgaggc attccagggg     1680

acttggcttc aggacagtgt cacaatgaag agggtgtcac atttctgtct cacagtcacc     1740

tgttatcccg tcctgtaccc cagtcgtccc ccgtcccgtc gtgtcccccc ctcaccccac     1800

cccgcctcag ctcctcccca tcaggctcct gtgtgcctct acctccctat cctacatagg     1860

acctctagat agtgttagag aaccacagag tgggggcctc ctgaggtcag gtggtcttga     1920

gggagaccag ctacactgat cctgcccttg tcaggagacc taggccttgg gagctatccc     1980

tgtctgagcc tcaggcctag ggcagtctgt aagctagctg accttggccc tcccggtagc     2040

ttgacttctt ccctcccctc cgcaggttgg ggcagaggct cctttacctc tggcagtaaa     2100

ggagcctggg cttcactgag ccccgggttg gtcccctgcc ctctggactt aacctgctgt     2160

ctcagtgtcc tctgacccct taggggtcca tgtcagtatt ggagtgtgtg ttgaattgtt     2220

gctccctccc acacactccc gtagccgccc agtttaggat ttccctacac ctgccctaac     2280

ccacgctttt gggttgggga tcttgccttt ccttgtcatt cccagcagag actgttcctt     2340

cctgctgtta gaggagtggc ttgtttattc actccaccct gccccctcct gtaaatggag     2400

aaacaggcct gaaatcaaac gggtaaagcc ctaggccatc cctgtcttcc tgtcccatgt     2460

ctgcccagtt gaatcccact ggtggcttcc cgggcactga ggagtaaaag cgcctagggc     2520

tggagaatag gtctgaaatg ggtttgtgac tccccacccc ctgccctgcc ctcaaagctt     2580

cagacccctc agggagcagc aggatgtggg atcgaggccc cttgggacag atgctttgaa     2640

tcttccaggg aagcctccga ttcttccagg tttgtcaccc ggagttagca tgtcccaggc     2700

tcgcagacaa cactgcaggg tgggagacag ctgggcacag ggggattctg ttgagcatgg     2760

gctctgaacc cacagaactg acaaagcccc tgcttcccca cccccacctc aggctcctgc     2820

gagcagtgct cctgcaccct tcccagcctg ttctgtactg gggacagcag tcttctccct     2880

gtcctcccat gtcctatatc cacccctccc cttggaaggt cctccccaca gtgacactgg     2940

acagccctgg ggcagctgag ccccagcctg gcttctggct ggaagcgcga tgaggagact     3000

tagcactcca cagtgtccct ggtggtaact gttcttatta actgattgtg ttttgttttg     3060

ttttgttttg ttttcatgga ccaaaatttt ttttgtactg tctccttaac tgatgtcacc     3120

cagttttaat aaaagacttc taaagagcag gtc                                  3153


<210> 83
<211> 515
<212> PRT
<213> Mus musculus

<400> 83
Met Ala Ala Arg Ala Gly Phe Gln Ser Val Ala Pro Ser Gly Gly Ala 
1               5                   10                  15      


Gly Ala Ser Gly Gly Ala Gly Val Ala Ala Ala Leu Gly Pro Gly Gly 
            20                  25                  30          


Thr Pro Gly Pro Pro Val Arg Met Gly Pro Ala Pro Gly Gln Gly Leu 
        35                  40                  45              


Tyr Arg Ser Pro Met Pro Gly Ala Ala Tyr Pro Arg Pro Gly Met Leu 
    50                  55                  60                  


Pro Gly Ser Arg Met Thr Pro Gln Gly Pro Ser Met Gly Pro Pro Gly 
65                  70                  75                  80  


Tyr Gly Gly Asn Pro Ser Val Arg Pro Gly Leu Ala Gln Ser Gly Met 
                85                  90                  95      


Asp Gln Ser Arg Lys Arg Pro Ala Pro Gln Gln Ile Gln Gln Val Gln 
            100                 105                 110         


Gln Gln Ala Val Gln Asn Arg Asn His Asn Ala Lys Lys Lys Lys Met 
        115                 120                 125             


Ala Asp Lys Ile Leu Pro Gln Arg Ile Arg Glu Leu Val Pro Glu Ser 
    130                 135                 140                 


Gln Ala Tyr Met Asp Leu Leu Ala Phe Glu Arg Lys Leu Asp Gln Thr 
145                 150                 155                 160 


Ile Met Arg Lys Arg Leu Asp Ile Gln Glu Ala Leu Lys Arg Pro Ile 
                165                 170                 175     


Lys Gln Lys Arg Lys Leu Arg Ile Phe Ile Ser Asn Thr Phe Asn Pro 
            180                 185                 190         


Ala Lys Ser Asp Ala Glu Asp Gly Glu Gly Thr Val Ala Ser Trp Glu 
        195                 200                 205             


Leu Arg Val Glu Gly Arg Leu Leu Glu Asp Ala Ala Leu Ser Lys Tyr 
    210                 215                 220                 


Asp Ala Thr Lys Gln Lys Arg Lys Phe Ser Ser Phe Phe Lys Ser Leu 
225                 230                 235                 240 


Val Ile Glu Leu Asp Lys Asp Leu Tyr Gly Pro Asp Asn His Leu Val 
                245                 250                 255     


Glu Trp His Arg Thr Ala Thr Thr Gln Glu Thr Asp Gly Phe Gln Val 
            260                 265                 270         


Lys Arg Pro Gly Asp Val Asn Val Arg Cys Thr Val Leu Leu Met Leu 
        275                 280                 285             


Asp Tyr Gln Pro Pro Gln Phe Lys Leu Asp Pro Arg Leu Ala Arg Leu 
    290                 295                 300                 


Leu Gly Ile His Thr Gln Thr Arg Pro Val Ile Ile Gln Ala Leu Trp 
305                 310                 315                 320 


Gln Tyr Ile Lys Thr His Lys Leu Gln Asp Pro His Glu Arg Glu Phe 
                325                 330                 335     


Val Leu Cys Asp Lys Tyr Leu Gln Gln Ile Phe Glu Ser Gln Arg Met 
            340                 345                 350         


Lys Phe Ser Glu Ile Pro Gln Arg Leu His Ala Leu Leu Met Pro Pro 
        355                 360                 365             


Glu Pro Ile Ile Ile Asn His Val Ile Ser Val Asp Pro Asn Asp Gln 
    370                 375                 380                 


Lys Lys Thr Ala Cys Tyr Asp Ile Asp Val Glu Val Asp Asp Thr Leu 
385                 390                 395                 400 


Lys Thr Gln Met Asn Ser Phe Leu Leu Ser Thr Ala Ser Gln Gln Glu 
                405                 410                 415     


Ile Ala Thr Leu Asp Asn Lys Ile His Glu Thr Ile Glu Thr Ile Asn 
            420                 425                 430         


Gln Leu Lys Thr Gln Arg Glu Phe Met Leu Ser Phe Ala Arg Asp Pro 
        435                 440                 445             


Gln Gly Phe Ile Asn Asp Trp Leu Gln Ser Gln Cys Arg Asp Leu Lys 
    450                 455                 460                 


Thr Met Thr Asp Val Val Gly Asn Pro Glu Glu Glu Arg Arg Ala Glu 
465                 470                 475                 480 


Phe Tyr Phe Gln Pro Trp Ala Gln Glu Ala Val Cys Arg Tyr Phe Tyr 
                485                 490                 495     


Ser Lys Val Gln Gln Arg Arg Gln Glu Leu Glu Gln Ala Leu Gly Ile 
            500                 505                 510         


Arg Asn Thr 
        515 


<210> 84
<211> 2770
<212> DNA
<213> Homo sapiens

<400> 84
gttgggcggg gcagggagtt cgtagccgcc tctgggtaac tcgactcggg cggccaaacc       60

tccggaggcc ggggacggaa ggcgggcccg cagcagatcc tggatccgga atctcccggg      120

caggagcgga atctgtcccg aaccgggtct gtgaggaact cgcgaacttg gattaggaaa      180

tcccggagcc cggatcgaca aatcccggaa cccggaatta agatcgccaa gtcccggatc      240

gcggagcaca gagcacggag tggactcgac gcggagcccg gagtccggat cgcggcaccg      300

cgggacggga cggagcgatg tcgggccgag gcgcgggcgg gttcccgctg cccccgctaa      360

gccctggcgg cggcgccgtg gctgcggccc tgggagcgcc gcctcccccc gcgggacccg      420

gcatgctgcc cggaccggcg ctccggggac cgggtccggc aggaggcgtg gggggccccg      480

gggccgccgc cttccgcccc atgggccccg cgggccccgc ggcgcagtac cagcgacctg      540

gcatgtcacc agggaaccgg atgcccatgg ctggcttgca ggtgggaccc cctgctggct      600

ccccatttgg tgcagcagct ccgcttcgac ctggcatgcc acccaccatg atggatccat      660

tccgaaaacg cctgcttgtg ccccaggcgc agcctcccat gcctgcccag cgccgggggt      720

taaagaggag gaagatggca gataaggttc tacctcagcg aatccgggag cttgttccag      780

agtctcaggc gtacatggat ctcttggctt ttgagcggaa gctggaccag accattgctc      840

gcaagcggat ggagatccag gaggccatca aaaagcctct gacacaaaag cgaaagcttc      900

ggatctacat ttccaatacg ttcagtccca gcaaggcgga aggcgatagt gcaggaactg      960

cagggacccc tgggggaacc ccagcagggg acaaggtggc ttcctgggaa ctccgagtgg     1020

aaggaaaact gctggatgat cctagcaaac agaagaggaa gttttcttca ttctttaaga     1080

gcctcgtcat tgagctggac aaggagctgt acgggcctga caatcacctg gtggagtggc     1140

accggatgcc caccacccag gagacagatg gcttccaagt aaaacggcct ggagacctca     1200

acgtcaagtg caccctcctg ctcatgctgg atcatcagcc tccccagtac aaattggacc     1260

cccgattggc aaggctgctg ggagtgcaca cgcagacgag ggccgccatc atgcaggccc     1320

tgtggcttta catcaagcac aaccagctgc aggatgggca cgagcgggag tacatcaact     1380

gcaaccgtta cttccgccag atcttcagtt gtggccgact ccgtttctcc gagattccca     1440

tgaagctggc agggttgctg cagcatccag accccattgt catcaaccat gtcattagtg     1500

tcgaccctaa cgaccagaag aagacagcct gttacgacat cgatgtggag gtggacgacc     1560

cactgaaggc ccaaatgagc aattttctgg cctctaccac caatcagcag gagatcgcct     1620

cccttgatgt caagatccat gagaccattg agtccatcaa ccagctgaag acccagagag     1680

atttcatgct cagttttagc accgaccccc aggacttcat ccaggaatgg ctccgttccc     1740

agcgccgaga cctcaagatc atcactgatg tgattggaaa tcctgaggag gagagacgag     1800

ctgctttcta ccaccagccc tgggcccagg aagcagtagg caggcacatc tttgccaagg     1860

tgcagcagcg aaggcaggaa ctggaacagg tgctgggaat tcgcctgacc taactgctca     1920

gggatctttc ttcccagccc tggagcctgg agggagacca ccctctgggt ccttgctggg     1980

gccgcagaca cgtaggctgg ggtgaggagt gtctgctgtc accctctact ctccagcttt     2040

agtcttataa atgtagtgat aggattcctt gttgcttggt ccccaaagcc ttatactttt     2100

tgcattggct ttaattgggt tcagcagatg cctcctctgc ccccctgcag gcaggcccaa     2160

gtaggactgc tggaggctgt gctttgacat tgtaagacat ttccgaacca aaggctgctg     2220

ggtttgcatg tttacagact ccccctgggg cgagggtcag agctggctct ggggagctgg     2280

gctaggaaga ggaggtgcag cccagactct tcctagcctt tctaaaccaa agttctttgc     2340

cattcctaca agcccagcct tgctgctggt tttttccttt cctttgggta tttgcactat     2400

tttgggagca agttttctat gtgggagcca ctttttttgt acaggggtaa gttgggggtt     2460

ttcagggagc ctgttaggtg cctccttctt ttctttcctc aatctatgca agcggctctg     2520

gccgccatca tctcctggga tgccagaggg ctgcctctcc agcggcttgg gccggggagg     2580

ggacactcca gttctctagc atggcctgag gtatggggta tgtgcatgtg gaggccaggg     2640

taaggtgaat ggggaggctg ggaggactgg tgttgccctt tggagcttgg tgaggagggt     2700

gggcctaggg cttggcgagt gccacatctg gcaggtttgg aaatttccaa ataaatcctt     2760

ttgtctattg                                                            2770


<210> 85
<211> 531
<212> PRT
<213> Homo sapiens

<400> 85
Met Ser Gly Arg Gly Ala Gly Gly Phe Pro Leu Pro Pro Leu Ser Pro 
1               5                   10                  15      


Gly Gly Gly Ala Val Ala Ala Ala Leu Gly Ala Pro Pro Pro Pro Ala 
            20                  25                  30          


Gly Pro Gly Met Leu Pro Gly Pro Ala Leu Arg Gly Pro Gly Pro Ala 
        35                  40                  45              


Gly Gly Val Gly Gly Pro Gly Ala Ala Ala Phe Arg Pro Met Gly Pro 
    50                  55                  60                  


Ala Gly Pro Ala Ala Gln Tyr Gln Arg Pro Gly Met Ser Pro Gly Asn 
65                  70                  75                  80  


Arg Met Pro Met Ala Gly Leu Gln Val Gly Pro Pro Ala Gly Ser Pro 
                85                  90                  95      


Phe Gly Ala Ala Ala Pro Leu Arg Pro Gly Met Pro Pro Thr Met Met 
            100                 105                 110         


Asp Pro Phe Arg Lys Arg Leu Leu Val Pro Gln Ala Gln Pro Pro Met 
        115                 120                 125             


Pro Ala Gln Arg Arg Gly Leu Lys Arg Arg Lys Met Ala Asp Lys Val 
    130                 135                 140                 


Leu Pro Gln Arg Ile Arg Glu Leu Val Pro Glu Ser Gln Ala Tyr Met 
145                 150                 155                 160 


Asp Leu Leu Ala Phe Glu Arg Lys Leu Asp Gln Thr Ile Ala Arg Lys 
                165                 170                 175     


Arg Met Glu Ile Gln Glu Ala Ile Lys Lys Pro Leu Thr Gln Lys Arg 
            180                 185                 190         


Lys Leu Arg Ile Tyr Ile Ser Asn Thr Phe Ser Pro Ser Lys Ala Glu 
        195                 200                 205             


Gly Asp Ser Ala Gly Thr Ala Gly Thr Pro Gly Gly Thr Pro Ala Gly 
    210                 215                 220                 


Asp Lys Val Ala Ser Trp Glu Leu Arg Val Glu Gly Lys Leu Leu Asp 
225                 230                 235                 240 


Asp Pro Ser Lys Gln Lys Arg Lys Phe Ser Ser Phe Phe Lys Ser Leu 
                245                 250                 255     


Val Ile Glu Leu Asp Lys Glu Leu Tyr Gly Pro Asp Asn His Leu Val 
            260                 265                 270         


Glu Trp His Arg Met Pro Thr Thr Gln Glu Thr Asp Gly Phe Gln Val 
        275                 280                 285             


Lys Arg Pro Gly Asp Leu Asn Val Lys Cys Thr Leu Leu Leu Met Leu 
    290                 295                 300                 


Asp His Gln Pro Pro Gln Tyr Lys Leu Asp Pro Arg Leu Ala Arg Leu 
305                 310                 315                 320 


Leu Gly Val His Thr Gln Thr Arg Ala Ala Ile Met Gln Ala Leu Trp 
                325                 330                 335     


Leu Tyr Ile Lys His Asn Gln Leu Gln Asp Gly His Glu Arg Glu Tyr 
            340                 345                 350         


Ile Asn Cys Asn Arg Tyr Phe Arg Gln Ile Phe Ser Cys Gly Arg Leu 
        355                 360                 365             


Arg Phe Ser Glu Ile Pro Met Lys Leu Ala Gly Leu Leu Gln His Pro 
    370                 375                 380                 


Asp Pro Ile Val Ile Asn His Val Ile Ser Val Asp Pro Asn Asp Gln 
385                 390                 395                 400 


Lys Lys Thr Ala Cys Tyr Asp Ile Asp Val Glu Val Asp Asp Pro Leu 
                405                 410                 415     


Lys Ala Gln Met Ser Asn Phe Leu Ala Ser Thr Thr Asn Gln Gln Glu 
            420                 425                 430         


Ile Ala Ser Leu Asp Val Lys Ile His Glu Thr Ile Glu Ser Ile Asn 
        435                 440                 445             


Gln Leu Lys Thr Gln Arg Asp Phe Met Leu Ser Phe Ser Thr Asp Pro 
    450                 455                 460                 


Gln Asp Phe Ile Gln Glu Trp Leu Arg Ser Gln Arg Arg Asp Leu Lys 
465                 470                 475                 480 


Ile Ile Thr Asp Val Ile Gly Asn Pro Glu Glu Glu Arg Arg Ala Ala 
                485                 490                 495     


Phe Tyr His Gln Pro Trp Ala Gln Glu Ala Val Gly Arg His Ile Phe 
            500                 505                 510         


Ala Lys Val Gln Gln Arg Arg Gln Glu Leu Glu Gln Val Leu Gly Ile 
        515                 520                 525             


Arg Leu Thr 
    530     


<210> 86
<211> 2341
<212> DNA
<213> Homo sapiens

<400> 86
agtaccaggt gagcaaggag gacgcgagcg gacgggggcg agaggcgctg cgagggcgcc       60

cgggccggcg gctgaagggg cctcgacgac ctggcatgtc accagggaac cggatgccca      120

tggctggctt gcaggtggga ccccctgctg gctccccatt tggtgcagca gctccgcttc      180

gacctggcat gccacccacc atgatggatc cattccgaaa acgcctgctt gtgccccagg      240

cgcagcctcc catgcctgcc cagcgccggg ggttaaagag gaggaagatg gcagataagg      300

ttctacctca gcgaatccgg gagcttgttc cagagtctca ggcgtacatg gatctcttgg      360

cttttgagcg gaagctggac cagaccattg ctcgcaagcg gatggagatc caggaggcca      420

tcaaaaagcc tctgacacaa aagcgaaagc ttcggatcta catttccaat acgttcagtc      480

ccagcaaggc ggaaggcgat agtgcaggaa ctgcagggac ccctggggga accccagcag      540

gggacaaggt ggcttcctgg gaactccgag tggaaggaaa actgctggat gatcctagca      600

aacagaagag gaagttttct tcattcttta agagcctcgt cattgagctg gacaaggagc      660

tgtacgggcc tgacaatcac ctggtggagt ggcaccggat gcccaccacc caggagacag      720

atggcttcca agtaaaacgg cctggagacc tcaacgtcaa gtgcaccctc ctgctcatgc      780

tggatcatca gcctccccag tacaaattgg acccccgatt ggcaaggctg ctgggagtgc      840

acacgcagac gagggccgcc atcatgcagg ccctgtggct ttacatcaag cacaaccagc      900

tgcaggatgg gcacgagcgg gagtacatca actgcaaccg ttacttccgc cagatcttca      960

gttgtggccg actccgtttc tccgagattc ccatgaagct ggcagggttg ctgcagcatc     1020

cagaccccat tgtcatcaac catgtcatta gtgtcgaccc taacgaccag aagaagacag     1080

cctgttacga catcgatgtg gaggtggacg acccactgaa ggcccaaatg agcaattttc     1140

tggcctctac caccaatcag caggagatcg cctcccttga tgtcaagatc catgagacca     1200

ttgagtccat caaccagctg aagacccaga gagatttcat gctcagtttt agcaccgacc     1260

cccaggactt catccaggaa tggctccgtt cccagcgccg agacctcaag atcatcactg     1320

atgtgattgg aaatcctgag gaggagagac gagctgcttt ctaccaccag ccctgggccc     1380

aggaagcagt aggcaggcac atctttgcca aggtgcagca gcgaaggcag gaactggaac     1440

aggtgctggg aattcgcctg acctaactgc tcagggatct ttcttcccag ccctggagcc     1500

tggagggaga ccaccctctg ggtccttgct ggggccgcag acacgtaggc tggggtgagg     1560

agtgtctgct gtcaccctct actctccagc tttagtctta taaatgtagt gataggattc     1620

cttgttgctt ggtccccaaa gccttatact ttttgcattg gctttaattg ggttcagcag     1680

atgcctcctc tgcccccctg caggcaggcc caagtaggac tgctggaggc tgtgctttga     1740

cattgtaaga catttccgaa ccaaaggctg ctgggtttgc atgtttacag actccccctg     1800

gggcgagggt cagagctggc tctggggagc tgggctagga agaggaggtg cagcccagac     1860

tcttcctagc ctttctaaac caaagttctt tgccattcct acaagcccag ccttgctgct     1920

ggttttttcc tttcctttgg gtatttgcac tattttggga gcaagttttc tatgtgggag     1980

ccactttttt tgtacagggg taagttgggg gttttcaggg agcctgttag gtgcctcctt     2040

cttttctttc ctcaatctat gcaagcggct ctggccgcca tcatctcctg ggatgccaga     2100

gggctgcctc tccagcggct tgggccgggg aggggacact ccagttctct agcatggcct     2160

gaggtatggg gtatgtgcat gtggaggcca gggtaaggtg aatggggagg ctgggaggac     2220

tggtgttgcc ctttggagct tggtgaggag ggtgggccta gggcttggcg agtgccacat     2280

ctggcaggtt tggaaatttc caaataaatc cttttgtcta ttgaaaaaaa aaaaaaaaaa     2340

a                                                                     2341


<210> 87
<211> 456
<212> PRT
<213> Homo sapiens

<400> 87
Met Ser Pro Gly Asn Arg Met Pro Met Ala Gly Leu Gln Val Gly Pro 
1               5                   10                  15      


Pro Ala Gly Ser Pro Phe Gly Ala Ala Ala Pro Leu Arg Pro Gly Met 
            20                  25                  30          


Pro Pro Thr Met Met Asp Pro Phe Arg Lys Arg Leu Leu Val Pro Gln 
        35                  40                  45              


Ala Gln Pro Pro Met Pro Ala Gln Arg Arg Gly Leu Lys Arg Arg Lys 
    50                  55                  60                  


Met Ala Asp Lys Val Leu Pro Gln Arg Ile Arg Glu Leu Val Pro Glu 
65                  70                  75                  80  


Ser Gln Ala Tyr Met Asp Leu Leu Ala Phe Glu Arg Lys Leu Asp Gln 
                85                  90                  95      


Thr Ile Ala Arg Lys Arg Met Glu Ile Gln Glu Ala Ile Lys Lys Pro 
            100                 105                 110         


Leu Thr Gln Lys Arg Lys Leu Arg Ile Tyr Ile Ser Asn Thr Phe Ser 
        115                 120                 125             


Pro Ser Lys Ala Glu Gly Asp Ser Ala Gly Thr Ala Gly Thr Pro Gly 
    130                 135                 140                 


Gly Thr Pro Ala Gly Asp Lys Val Ala Ser Trp Glu Leu Arg Val Glu 
145                 150                 155                 160 


Gly Lys Leu Leu Asp Asp Pro Ser Lys Gln Lys Arg Lys Phe Ser Ser 
                165                 170                 175     


Phe Phe Lys Ser Leu Val Ile Glu Leu Asp Lys Glu Leu Tyr Gly Pro 
            180                 185                 190         


Asp Asn His Leu Val Glu Trp His Arg Met Pro Thr Thr Gln Glu Thr 
        195                 200                 205             


Asp Gly Phe Gln Val Lys Arg Pro Gly Asp Leu Asn Val Lys Cys Thr 
    210                 215                 220                 


Leu Leu Leu Met Leu Asp His Gln Pro Pro Gln Tyr Lys Leu Asp Pro 
225                 230                 235                 240 


Arg Leu Ala Arg Leu Leu Gly Val His Thr Gln Thr Arg Ala Ala Ile 
                245                 250                 255     


Met Gln Ala Leu Trp Leu Tyr Ile Lys His Asn Gln Leu Gln Asp Gly 
            260                 265                 270         


His Glu Arg Glu Tyr Ile Asn Cys Asn Arg Tyr Phe Arg Gln Ile Phe 
        275                 280                 285             


Ser Cys Gly Arg Leu Arg Phe Ser Glu Ile Pro Met Lys Leu Ala Gly 
    290                 295                 300                 


Leu Leu Gln His Pro Asp Pro Ile Val Ile Asn His Val Ile Ser Val 
305                 310                 315                 320 


Asp Pro Asn Asp Gln Lys Lys Thr Ala Cys Tyr Asp Ile Asp Val Glu 
                325                 330                 335     


Val Asp Asp Pro Leu Lys Ala Gln Met Ser Asn Phe Leu Ala Ser Thr 
            340                 345                 350         


Thr Asn Gln Gln Glu Ile Ala Ser Leu Asp Val Lys Ile His Glu Thr 
        355                 360                 365             


Ile Glu Ser Ile Asn Gln Leu Lys Thr Gln Arg Asp Phe Met Leu Ser 
    370                 375                 380                 


Phe Ser Thr Asp Pro Gln Asp Phe Ile Gln Glu Trp Leu Arg Ser Gln 
385                 390                 395                 400 


Arg Arg Asp Leu Lys Ile Ile Thr Asp Val Ile Gly Asn Pro Glu Glu 
                405                 410                 415     


Glu Arg Arg Ala Ala Phe Tyr His Gln Pro Trp Ala Gln Glu Ala Val 
            420                 425                 430         


Gly Arg His Ile Phe Ala Lys Val Gln Gln Arg Arg Gln Glu Leu Glu 
        435                 440                 445             


Gln Val Leu Gly Ile Arg Leu Thr 
    450                 455     


<210> 88
<211> 2374
<212> DNA
<213> Homo sapiens

<400> 88
agtgtgtgca aggcagagct gccaaacagg ccttgcaggc agcagccatg gggaggcggg       60

tgggggtgga ggtgactccc agatgggctc cacagaaatg tcagggagca aggcctcagc      120

gacctggcat gtcaccaggg aaccggatgc ccatggctgg cttgcaggtg ggaccccctg      180

ctggctcccc atttggtgca gcagctccgc ttcgacctgg catgccaccc accatgatgg      240

atccattccg aaaacgcctg cttgtgcccc aggcgcagcc tcccatgcct gcccagcgcc      300

gggggttaaa gaggaggaag atggcagata aggttctacc tcagcgaatc cgggagcttg      360

ttccagagtc tcaggcgtac atggatctct tggcttttga gcggaagctg gaccagacca      420

ttgctcgcaa gcggatggag atccaggagg ccatcaaaaa gcctctgaca caaaagcgaa      480

agcttcggat ctacatttcc aatacgttca gtcccagcaa ggcggaaggc gatagtgcag      540

gaactgcagg gacccctggg ggaaccccag caggggacaa ggtggcttcc tgggaactcc      600

gagtggaagg aaaactgctg gatgatccta gcaaacagaa gaggaagttt tcttcattct      660

ttaagagcct cgtcattgag ctggacaagg agctgtacgg gcctgacaat cacctggtgg      720

agtggcaccg gatgcccacc acccaggaga cagatggctt ccaagtaaaa cggcctggag      780

acctcaacgt caagtgcacc ctcctgctca tgctggatca tcagcctccc cagtacaaat      840

tggacccccg attggcaagg ctgctgggag tgcacacgca gacgagggcc gccatcatgc      900

aggccctgtg gctttacatc aagcacaacc agctgcagga tgggcacgag cgggagtaca      960

tcaactgcaa ccgttacttc cgccagatct tcagttgtgg ccgactccgt ttctccgaga     1020

ttcccatgaa gctggcaggg ttgctgcagc atccagaccc cattgtcatc aaccatgtca     1080

ttagtgtcga ccctaacgac cagaagaaga cagcctgtta cgacatcgat gtggaggtgg     1140

acgacccact gaaggcccaa atgagcaatt ttctggcctc taccaccaat cagcaggaga     1200

tcgcctccct tgatgtcaag atccatgaga ccattgagtc catcaaccag ctgaagaccc     1260

agagagattt catgctcagt tttagcaccg acccccagga cttcatccag gaatggctcc     1320

gttcccagcg ccgagacctc aagatcatca ctgatgtgat tggaaatcct gaggaggaga     1380

gacgagctgc tttctaccac cagccctggg cccaggaagc agtaggcagg cacatctttg     1440

ccaaggtgca gcagcgaagg caggaactgg aacaggtgct gggaattcgc ctgacctaac     1500

tgctcaggga tctttcttcc cagccctgga gcctggaggg agaccaccct ctgggtcctt     1560

gctggggccg cagacacgta ggctggggtg aggagtgtct gctgtcaccc tctactctcc     1620

agctttagtc ttataaatgt agtgatagga ttccttgttg cttggtcccc aaagccttat     1680

actttttgca ttggctttaa ttgggttcag cagatgcctc ctctgccccc ctgcaggcag     1740

gcccaagtag gactgctgga ggctgtgctt tgacattgta agacatttcc gaaccaaagg     1800

ctgctgggtt tgcatgttta cagactcccc ctggggcgag ggtcagagct ggctctgggg     1860

agctgggcta ggaagaggag gtgcagccca gactcttcct agcctttcta aaccaaagtt     1920

ctttgccatt cctacaagcc cagccttgct gctggttttt tcctttcctt tgggtatttg     1980

cactattttg ggagcaagtt ttctatgtgg gagccacttt ttttgtacag gggtaagttg     2040

ggggttttca gggagcctgt taggtgcctc cttcttttct ttcctcaatc tatgcaagcg     2100

gctctggccg ccatcatctc ctgggatgcc agagggctgc ctctccagcg gcttgggccg     2160

gggaggggac actccagttc tctagcatgg cctgaggtat ggggtatgtg catgtggagg     2220

ccagggtaag gtgaatgggg aggctgggag gactggtgtt gccctttgga gcttggtgag     2280

gagggtgggc ctagggcttg gcgagtgcca catctggcag gtttggaaat ttccaaataa     2340

atccttttgt ctattgaaaa aaaaaaaaaa aaaa                                 2374


<210> 89
<211> 483
<212> PRT
<213> Homo sapiens

<400> 89
Met Gly Arg Arg Val Gly Val Glu Val Thr Pro Arg Trp Ala Pro Gln 
1               5                   10                  15      


Lys Cys Gln Gly Ala Arg Pro Gln Arg Pro Gly Met Ser Pro Gly Asn 
            20                  25                  30          


Arg Met Pro Met Ala Gly Leu Gln Val Gly Pro Pro Ala Gly Ser Pro 
        35                  40                  45              


Phe Gly Ala Ala Ala Pro Leu Arg Pro Gly Met Pro Pro Thr Met Met 
    50                  55                  60                  


Asp Pro Phe Arg Lys Arg Leu Leu Val Pro Gln Ala Gln Pro Pro Met 
65                  70                  75                  80  


Pro Ala Gln Arg Arg Gly Leu Lys Arg Arg Lys Met Ala Asp Lys Val 
                85                  90                  95      


Leu Pro Gln Arg Ile Arg Glu Leu Val Pro Glu Ser Gln Ala Tyr Met 
            100                 105                 110         


Asp Leu Leu Ala Phe Glu Arg Lys Leu Asp Gln Thr Ile Ala Arg Lys 
        115                 120                 125             


Arg Met Glu Ile Gln Glu Ala Ile Lys Lys Pro Leu Thr Gln Lys Arg 
    130                 135                 140                 


Lys Leu Arg Ile Tyr Ile Ser Asn Thr Phe Ser Pro Ser Lys Ala Glu 
145                 150                 155                 160 


Gly Asp Ser Ala Gly Thr Ala Gly Thr Pro Gly Gly Thr Pro Ala Gly 
                165                 170                 175     


Asp Lys Val Ala Ser Trp Glu Leu Arg Val Glu Gly Lys Leu Leu Asp 
            180                 185                 190         


Asp Pro Ser Lys Gln Lys Arg Lys Phe Ser Ser Phe Phe Lys Ser Leu 
        195                 200                 205             


Val Ile Glu Leu Asp Lys Glu Leu Tyr Gly Pro Asp Asn His Leu Val 
    210                 215                 220                 


Glu Trp His Arg Met Pro Thr Thr Gln Glu Thr Asp Gly Phe Gln Val 
225                 230                 235                 240 


Lys Arg Pro Gly Asp Leu Asn Val Lys Cys Thr Leu Leu Leu Met Leu 
                245                 250                 255     


Asp His Gln Pro Pro Gln Tyr Lys Leu Asp Pro Arg Leu Ala Arg Leu 
            260                 265                 270         


Leu Gly Val His Thr Gln Thr Arg Ala Ala Ile Met Gln Ala Leu Trp 
        275                 280                 285             


Leu Tyr Ile Lys His Asn Gln Leu Gln Asp Gly His Glu Arg Glu Tyr 
    290                 295                 300                 


Ile Asn Cys Asn Arg Tyr Phe Arg Gln Ile Phe Ser Cys Gly Arg Leu 
305                 310                 315                 320 


Arg Phe Ser Glu Ile Pro Met Lys Leu Ala Gly Leu Leu Gln His Pro 
                325                 330                 335     


Asp Pro Ile Val Ile Asn His Val Ile Ser Val Asp Pro Asn Asp Gln 
            340                 345                 350         


Lys Lys Thr Ala Cys Tyr Asp Ile Asp Val Glu Val Asp Asp Pro Leu 
        355                 360                 365             


Lys Ala Gln Met Ser Asn Phe Leu Ala Ser Thr Thr Asn Gln Gln Glu 
    370                 375                 380                 


Ile Ala Ser Leu Asp Val Lys Ile His Glu Thr Ile Glu Ser Ile Asn 
385                 390                 395                 400 


Gln Leu Lys Thr Gln Arg Asp Phe Met Leu Ser Phe Ser Thr Asp Pro 
                405                 410                 415     


Gln Asp Phe Ile Gln Glu Trp Leu Arg Ser Gln Arg Arg Asp Leu Lys 
            420                 425                 430         


Ile Ile Thr Asp Val Ile Gly Asn Pro Glu Glu Glu Arg Arg Ala Ala 
        435                 440                 445             


Phe Tyr His Gln Pro Trp Ala Gln Glu Ala Val Gly Arg His Ile Phe 
    450                 455                 460                 


Ala Lys Val Gln Gln Arg Arg Gln Glu Leu Glu Gln Val Leu Gly Ile 
465                 470                 475                 480 


Arg Leu Thr 
            


<210> 90
<211> 2767
<212> DNA
<213> Mus musculus

<400> 90
ctccggcgat caaacctccg gaggccggga gaggcctgcg ggctcgcggc acatcccgga       60

tctggagtat ccctggcagg agcggagtca gaggggccgc gggatcctaa agccgggctg      120

caaagaactt gcgaacttgg agtagaagat cccggaaccc ggtagtaaaa tcgggaagtc      180

ccggatcgcg gaacgtagct cgcggagcgg actcaacacg gagaccggag gccggatcgc      240

tgcaccgcgg gacgggacag agtgatgtcc ggccgtggcg cgggcgggtt cccgctgcct      300

ccgctgagcc ccggcggcgg cgccgttgcc gcggcccttg gtgcgccgcc tccgcctgcg      360

ggacccggaa tgctgcccag cccggcgctc aggggcccgg ggccttctgg aggcatgggg      420

gtaccggggg ccgccgcctt ccgccccatg ggccccgctg gccccgcggc gcagtaccag      480

cgtcctggca tgtcaccagg aagcaggatg cccatggctg gcttgcaggt gggacctcct      540

gccggttccc catttggcac agctgctccg ctccgacctg gcatgccacc taccatgatg      600

gatccattcc gaaaacgcct gcttgtgcct caggcccagc ccccgatgcc tgcccagcgc      660

cgagggttaa agaggaggaa gatggcagat aaggttctac ctcagcgaat ccgggagctt      720

gtcccagagt ctcaggcata catggatctt ttagctttcg agaggaagct ggaccagacc      780

atcgctcgca agcggatgga gattcaagag gccatcaaga agcctctgac gcaaaagcga      840

aaacttcgga tctatatttc caatacattc agccccagca aggcggatgg agataatgcg      900

ggaactgcgg ggacccctgg gggaaccccg gcagcagaca aggtggcctc ctgggagctt      960

cgagtagagg ggaaactgct ggatgatcct agcaaacaga agaggaagtt ctcatcattc     1020

tttaagagcc ttgtgattga gttggacaag gaactctatg ggccggacaa ccatctggtg     1080

gagtggcatc ggatgcccac cacacaggaa acagatggct ttcaggtgaa acggccagga     1140

gatctcaatg tcaagtgcac ccttctgctc atgctggatc atcagcctcc tcagtataaa     1200

ctggaccccc gcctggcgag gttgctggga gtgcacacac agaccagggc ggcaatcatg     1260

caggcactgt ggctttacat caaacacaac cagctgcagg acggccatga gcgcgagtac     1320

atcaactgca atcgttactt ccgccagatc ttcagttgtg gccgactccg tttctccgag     1380

attcccatga agctggctgg attgctgcag catccagacc ccattgttat taatcatgtc     1440

attagtgtgg atcctaatga ccaaaagaag acagcctgct atgacattga tgtagaggtt     1500

gatgacccac tgaaggccca gatgagcaac ttcctggcct ctaccaccaa ccagcaggag     1560

attgcttctc ttgacgtcaa gatccatgag accattgagt ccatcaacca gctaaagacc     1620

cagagggatt tcatgctcag ctttagcacc gagccccagg acttcatcca ggagtggctc     1680

cgttcccaac gccgagacct caagatcatc acagatgtga ttggaaaccc tgaggaggag     1740

agacgagctg ctttctacca ccagccctgg gctcaggaag cagtggggag gcacatcttt     1800

gccaaggtgc agcagcgaag gcaggaactg gaacaggtgc tgggaattcg cctgacctaa     1860

ctgctcaggg attgcctcct tccttcctcc cctgccctgg atggaacctg gcaagagccc     1920

gtcctctggg ttctggcttg ggctgcagac atgtaggatg gagtgaggtg tgtttcctgt     1980

caccctccac tccccagctt tagtttcata aatgtagttt tagatccctc actgcttggt     2040

tcccaaagcc ttattactga ccttttagcg ctggctttaa ttgggtttgc aatgagcggc     2100

ctcagccccc tgcaggcagg caggcctgag taggaggctg gaggctgtgc tttaactttg     2160

taccagacat ttccaaacca aaggctgctg ggtttgcatg tttacaggct ccaccctagg     2220

gccagtgcca gagctggctt tggggagctg ggcaaggaag agaaggccct agactcttcc     2280

tggcctttct aaccaaagtt ttttgccatt cctacaagcc cagtcttgct gctggtttgt     2340

ccttcttttt gggtatttgc actatttggg gagcaggttt ttctatgtgg gagccacttt     2400

tttgtacaga ggtaatgggg tttttcaggg agcccacttg gtgcctcctt cttcctttct     2460

tttcttaatc tatgcaagcg gctgcagccg ccatcatctc ctggtatgcc acaaggctgc     2520

ccacccatag ctgcttgggc agggggaggt ggaatctcct gagagtggca atgccagttc     2580

tctaacccag ttacagcagg ggtgtgtgtg cgtgcgtgcg tgcgtgctgc aggggaaggg     2640

gaaagctgga ggactgctgt taccttttgc agtcggtctt aaagaggatg ggcctaaggc     2700

ttggcaaact tggaaaattc caaataaatc tttttgttta ttggtggtgc ccagaaaaaa     2760

aaaaaaa                                                               2767


<210> 91
<211> 531
<212> PRT
<213> Mus musculus

<400> 91
Met Ser Gly Arg Gly Ala Gly Gly Phe Pro Leu Pro Pro Leu Ser Pro 
1               5                   10                  15      


Gly Gly Gly Ala Val Ala Ala Ala Leu Gly Ala Pro Pro Pro Pro Ala 
            20                  25                  30          


Gly Pro Gly Met Leu Pro Ser Pro Ala Leu Arg Gly Pro Gly Pro Ser 
        35                  40                  45              


Gly Gly Met Gly Val Pro Gly Ala Ala Ala Phe Arg Pro Met Gly Pro 
    50                  55                  60                  


Ala Gly Pro Ala Ala Gln Tyr Gln Arg Pro Gly Met Ser Pro Gly Ser 
65                  70                  75                  80  


Arg Met Pro Met Ala Gly Leu Gln Val Gly Pro Pro Ala Gly Ser Pro 
                85                  90                  95      


Phe Gly Thr Ala Ala Pro Leu Arg Pro Gly Met Pro Pro Thr Met Met 
            100                 105                 110         


Asp Pro Phe Arg Lys Arg Leu Leu Val Pro Gln Ala Gln Pro Pro Met 
        115                 120                 125             


Pro Ala Gln Arg Arg Gly Leu Lys Arg Arg Lys Met Ala Asp Lys Val 
    130                 135                 140                 


Leu Pro Gln Arg Ile Arg Glu Leu Val Pro Glu Ser Gln Ala Tyr Met 
145                 150                 155                 160 


Asp Leu Leu Ala Phe Glu Arg Lys Leu Asp Gln Thr Ile Ala Arg Lys 
                165                 170                 175     


Arg Met Glu Ile Gln Glu Ala Ile Lys Lys Pro Leu Thr Gln Lys Arg 
            180                 185                 190         


Lys Leu Arg Ile Tyr Ile Ser Asn Thr Phe Ser Pro Ser Lys Ala Asp 
        195                 200                 205             


Gly Asp Asn Ala Gly Thr Ala Gly Thr Pro Gly Gly Thr Pro Ala Ala 
    210                 215                 220                 


Asp Lys Val Ala Ser Trp Glu Leu Arg Val Glu Gly Lys Leu Leu Asp 
225                 230                 235                 240 


Asp Pro Ser Lys Gln Lys Arg Lys Phe Ser Ser Phe Phe Lys Ser Leu 
                245                 250                 255     


Val Ile Glu Leu Asp Lys Glu Leu Tyr Gly Pro Asp Asn His Leu Val 
            260                 265                 270         


Glu Trp His Arg Met Pro Thr Thr Gln Glu Thr Asp Gly Phe Gln Val 
        275                 280                 285             


Lys Arg Pro Gly Asp Leu Asn Val Lys Cys Thr Leu Leu Leu Met Leu 
    290                 295                 300                 


Asp His Gln Pro Pro Gln Tyr Lys Leu Asp Pro Arg Leu Ala Arg Leu 
305                 310                 315                 320 


Leu Gly Val His Thr Gln Thr Arg Ala Ala Ile Met Gln Ala Leu Trp 
                325                 330                 335     


Leu Tyr Ile Lys His Asn Gln Leu Gln Asp Gly His Glu Arg Glu Tyr 
            340                 345                 350         


Ile Asn Cys Asn Arg Tyr Phe Arg Gln Ile Phe Ser Cys Gly Arg Leu 
        355                 360                 365             


Arg Phe Ser Glu Ile Pro Met Lys Leu Ala Gly Leu Leu Gln His Pro 
    370                 375                 380                 


Asp Pro Ile Val Ile Asn His Val Ile Ser Val Asp Pro Asn Asp Gln 
385                 390                 395                 400 


Lys Lys Thr Ala Cys Tyr Asp Ile Asp Val Glu Val Asp Asp Pro Leu 
                405                 410                 415     


Lys Ala Gln Met Ser Asn Phe Leu Ala Ser Thr Thr Asn Gln Gln Glu 
            420                 425                 430         


Ile Ala Ser Leu Asp Val Lys Ile His Glu Thr Ile Glu Ser Ile Asn 
        435                 440                 445             


Gln Leu Lys Thr Gln Arg Asp Phe Met Leu Ser Phe Ser Thr Glu Pro 
    450                 455                 460                 


Gln Asp Phe Ile Gln Glu Trp Leu Arg Ser Gln Arg Arg Asp Leu Lys 
465                 470                 475                 480 


Ile Ile Thr Asp Val Ile Gly Asn Pro Glu Glu Glu Arg Arg Ala Ala 
                485                 490                 495     


Phe Tyr His Gln Pro Trp Ala Gln Glu Ala Val Gly Arg His Ile Phe 
            500                 505                 510         


Ala Lys Val Gln Gln Arg Arg Gln Glu Leu Glu Gln Val Leu Gly Ile 
        515                 520                 525             


Arg Leu Thr 
    530     


<210> 92
<211> 2401
<212> DNA
<213> Mus musculus

<400> 92
tttgttcctg gtctccccat ttgagagaga gagagagaga tggagggtat gggctatgga       60

cctcggaggg ctccgccact gacctgtgtc cctccactgt tccactttcc tcagcgtcct      120

ggcatgtcac caggaagcag gatgcccatg gctggcttgc aggtgggacc tcctgccggt      180

tccccatttg gcacagctgc tccgctccga cctggcatgc cacctaccat gatggatcca      240

ttccgaaaac gcctgcttgt gcctcaggcc cagcccccga tgcctgccca gcgccgaggg      300

ttaaagagga ggaagatggc agataaggtt ctacctcagc gaatccggga gcttgtccca      360

gagtctcagg catacatgga tcttttagct ttcgagagga agctggacca gaccatcgct      420

cgcaagcgga tggagattca agaggccatc aagaagcctc tgacgcaaaa gcgaaaactt      480

cggatctata tttccaatac attcagcccc agcaaggcgg atggagataa tgcgggaact      540

gcggggaccc ctgggggaac cccggcagca gacaaggtgg cctcctggga gcttcgagta      600

gaggggaaac tgctggatga tcctagcaaa cagaagagga agttctcatc attctttaag      660

agccttgtga ttgagttgga caaggaactc tatgggccgg acaaccatct ggtggagtgg      720

catcggatgc ccaccacaca ggaaacagat ggctttcagg tgaaacggcc aggagatctc      780

aatgtcaagt gcacccttct gctcatgctg gatcatcagc ctcctcagta taaactggac      840

ccccgcctgg cgaggttgct gggagtgcac acacagacca gggcggcaat catgcaggca      900

ctgtggcttt acatcaaaca caaccagctg caggacggcc atgagcgcga gtacatcaac      960

tgcaatcgtt acttccgcca gatcttcagt tgtggccgac tccgtttctc cgagattccc     1020

atgaagctgg ctggattgct gcagcatcca gaccccattg ttattaatca tgtcattagt     1080

gtggatccta atgaccaaaa gaagacagcc tgctatgaca ttgatgtaga ggttgatgac     1140

ccactgaagg cccagatgag caacttcctg gcctctacca ccaaccagca ggagattgct     1200

tctcttgacg tcaagatcca tgagaccatt gagtccatca accagctaaa gacccagagg     1260

gatttcatgc tcagctttag caccgagccc caggacttca tccaggagtg gctccgttcc     1320

caacgccgag acctcaagat catcacagat gtgattggaa accctgagga ggagagacga     1380

gctgctttct accaccagcc ctgggctcag gaagcagtgg ggaggcacat ctttgccaag     1440

gtgcagcagc gaaggcagga actggaacag gtgctgggaa ttcgcctgac ctaactgctc     1500

agggattgcc tccttccttc ctcccctgcc ctggatggaa cctggcaaga gcccgtcctc     1560

tgggttctgg cttgggctgc agacatgtag gatggagtga ggtgtgtttc ctgtcaccct     1620

ccactcccca gctttagttt cataaatgta gttttagatc cctcactgct tggttcccaa     1680

agccttatta ctgacctttt agcgctggct ttaattgggt ttgcaatgag cggcctcagc     1740

cccctgcagg caggcaggcc tgagtaggag gctggaggct gtgctttaac tttgtaccag     1800

acatttccaa accaaaggct gctgggtttg catgtttaca ggctccaccc tagggccagt     1860

gccagagctg gctttgggga gctgggcaag gaagagaagg ccctagactc ttcctggcct     1920

ttctaaccaa agttttttgc cattcctaca agcccagtct tgctgctggt ttgtccttct     1980

ttttgggtat ttgcactatt tggggagcag gtttttctat gtgggagcca cttttttgta     2040

cagaggtaat ggggtttttc agggagccca cttggtgcct ccttcttcct ttcttttctt     2100

aatctatgca agcggctgca gccgccatca tctcctggta tgccacaagg ctgcccaccc     2160

atagctgctt gggcaggggg aggtggaatc tcctgagagt ggcaatgcca gttctctaac     2220

ccagttacag caggggtgtg tgtgcgtgcg tgcgtgcgtg ctgcagggga aggggaaagc     2280

tggaggactg ctgttacctt ttgcagtcgg tcttaaagag gatgggccta aggcttggca     2340

aacttggaaa attccaaata aatctttttg tttattggtg gtgcccagaa aaaaaaaaaa     2400

a                                                                     2401


<210> 93
<211> 484
<212> PRT
<213> Mus musculus

<400> 93
Met Glu Gly Met Gly Tyr Gly Pro Arg Arg Ala Pro Pro Leu Thr Cys 
1               5                   10                  15      


Val Pro Pro Leu Phe His Phe Pro Gln Arg Pro Gly Met Ser Pro Gly 
            20                  25                  30          


Ser Arg Met Pro Met Ala Gly Leu Gln Val Gly Pro Pro Ala Gly Ser 
        35                  40                  45              


Pro Phe Gly Thr Ala Ala Pro Leu Arg Pro Gly Met Pro Pro Thr Met 
    50                  55                  60                  


Met Asp Pro Phe Arg Lys Arg Leu Leu Val Pro Gln Ala Gln Pro Pro 
65                  70                  75                  80  


Met Pro Ala Gln Arg Arg Gly Leu Lys Arg Arg Lys Met Ala Asp Lys 
                85                  90                  95      


Val Leu Pro Gln Arg Ile Arg Glu Leu Val Pro Glu Ser Gln Ala Tyr 
            100                 105                 110         


Met Asp Leu Leu Ala Phe Glu Arg Lys Leu Asp Gln Thr Ile Ala Arg 
        115                 120                 125             


Lys Arg Met Glu Ile Gln Glu Ala Ile Lys Lys Pro Leu Thr Gln Lys 
    130                 135                 140                 


Arg Lys Leu Arg Ile Tyr Ile Ser Asn Thr Phe Ser Pro Ser Lys Ala 
145                 150                 155                 160 


Asp Gly Asp Asn Ala Gly Thr Ala Gly Thr Pro Gly Gly Thr Pro Ala 
                165                 170                 175     


Ala Asp Lys Val Ala Ser Trp Glu Leu Arg Val Glu Gly Lys Leu Leu 
            180                 185                 190         


Asp Asp Pro Ser Lys Gln Lys Arg Lys Phe Ser Ser Phe Phe Lys Ser 
        195                 200                 205             


Leu Val Ile Glu Leu Asp Lys Glu Leu Tyr Gly Pro Asp Asn His Leu 
    210                 215                 220                 


Val Glu Trp His Arg Met Pro Thr Thr Gln Glu Thr Asp Gly Phe Gln 
225                 230                 235                 240 


Val Lys Arg Pro Gly Asp Leu Asn Val Lys Cys Thr Leu Leu Leu Met 
                245                 250                 255     


Leu Asp His Gln Pro Pro Gln Tyr Lys Leu Asp Pro Arg Leu Ala Arg 
            260                 265                 270         


Leu Leu Gly Val His Thr Gln Thr Arg Ala Ala Ile Met Gln Ala Leu 
        275                 280                 285             


Trp Leu Tyr Ile Lys His Asn Gln Leu Gln Asp Gly His Glu Arg Glu 
    290                 295                 300                 


Tyr Ile Asn Cys Asn Arg Tyr Phe Arg Gln Ile Phe Ser Cys Gly Arg 
305                 310                 315                 320 


Leu Arg Phe Ser Glu Ile Pro Met Lys Leu Ala Gly Leu Leu Gln His 
                325                 330                 335     


Pro Asp Pro Ile Val Ile Asn His Val Ile Ser Val Asp Pro Asn Asp 
            340                 345                 350         


Gln Lys Lys Thr Ala Cys Tyr Asp Ile Asp Val Glu Val Asp Asp Pro 
        355                 360                 365             


Leu Lys Ala Gln Met Ser Asn Phe Leu Ala Ser Thr Thr Asn Gln Gln 
    370                 375                 380                 


Glu Ile Ala Ser Leu Asp Val Lys Ile His Glu Thr Ile Glu Ser Ile 
385                 390                 395                 400 


Asn Gln Leu Lys Thr Gln Arg Asp Phe Met Leu Ser Phe Ser Thr Glu 
                405                 410                 415     


Pro Gln Asp Phe Ile Gln Glu Trp Leu Arg Ser Gln Arg Arg Asp Leu 
            420                 425                 430         


Lys Ile Ile Thr Asp Val Ile Gly Asn Pro Glu Glu Glu Arg Arg Ala 
        435                 440                 445             


Ala Phe Tyr His Gln Pro Trp Ala Gln Glu Ala Val Gly Arg His Ile 
    450                 455                 460                 


Phe Ala Lys Val Gln Gln Arg Arg Gln Glu Leu Glu Gln Val Leu Gly 
465                 470                 475                 480 


Ile Arg Leu Thr 
                


<210> 94
<211> 1689
<212> DNA
<213> Homo sapiens

<400> 94
ctggcatctt cctcccctcc tcctttccag atcctcagaa tggcccttgg tgctgcaggc       60

gcggtgggct ccgggcccag gcaccgaggg ggcactggat gactctccag gtgcaggacc      120

ctgccatcta tgactccagg tcttcagcac ccacccaccg tggtacagcg ccccgggatg      180

ccgtctggag cccggatgcc ccaccagggg gcgcccatgg gccccccggg ctccccgtac      240

atgggcagcc ccgccgtgcg acccggcctg gcccccgcgg gcatggagcc cgcccgcaag      300

cgagcagcgc ccccgcccgg gcagagccag gcacagagcc agggccagcc ggtgcccacc      360

gcccccgcgc ggagccgcag tgccaagagg aggaagatgg ctgacaaaat cctccctcaa      420

aggattcggg agctggtccc cgagtcccag gcttacatgg acctcttggc atttgagagg      480

aaactggatc aaaccatcat gcggaagcgg gtggacatcc aggaggctct gaagaggccc      540

atgaagcaaa agcggaagct gcgactctat atctccaaca cttttaaccc tgcgaagcct      600

gatgctgagg attccgacgg cagcattgcc tcctgggagc tacgggtgga ggggaagctc      660

ctggatgatc ccagcaaaca gaagcggaag ttctcttctt tcttcaagag tttggtcatc      720

gagctggaca aagatcttta tggccctgac aaccacctcg ttgagtggca tcggacaccc      780

acgacccagg agacggacgg cttccaggtg aaacggcctg gggacctgag tgtgcgctgc      840

acgctgctcc tcatgctgga ctaccagcct ccccagttca aactggatcc ccgcctagcc      900

cggctgctgg ggctgcacac acagagccgc tcagccattg tccaggccct gtggcagtat      960

gtgaagacca acaggctgca ggactcccat gacaaggaat acatcaatgg ggacaagtat     1020

ttccagcaga tttttgattg tccccggctg aagttttctg agattcccca gcgcctcaca     1080

gccctgctat tgccccctga cccaattgtc atcaaccatg tcatcagcgt ggacccttca     1140

gaccagaaga agacggcgtg ctatgacatt gacgtggagg tggaggagcc attaaagggg     1200

cagatgagca gcttcctcct atccacggcc aaccagcagg agatcagtgc tctggacagt     1260

aagatccatg agacgattga gtccataaac cagctcaaga tccagaggga cttcatgcta     1320

agcttctcca gagaccccaa aggctatgtc caagacctgc tccgctccca gagccgggac     1380

ctcaaggtga tgacagatgt agccggcaac cctgaagagg agcgccgggc tgagttctac     1440

caccagccct ggtcccagga ggccgtcagt cgctacttct actgcaagat ccagcagcgc     1500

aggcaggagc tggagcagtc gctggttgtg cgcaacacct aggagcccaa aaataagcag     1560

cacgacggaa ctttcagccg tgtcccgggc cccagcattt tgccccgggc tccagcatca     1620

ctcctctgcc accttggggt gtggggctgg attaaaagtc attcatctga caaaaaaaaa     1680

aaaaaaaaa                                                             1689


<210> 95
<211> 470
<212> PRT
<213> Homo sapiens

<400> 95
Met Thr Pro Gly Leu Gln His Pro Pro Thr Val Val Gln Arg Pro Gly 
1               5                   10                  15      


Met Pro Ser Gly Ala Arg Met Pro His Gln Gly Ala Pro Met Gly Pro 
            20                  25                  30          


Pro Gly Ser Pro Tyr Met Gly Ser Pro Ala Val Arg Pro Gly Leu Ala 
        35                  40                  45              


Pro Ala Gly Met Glu Pro Ala Arg Lys Arg Ala Ala Pro Pro Pro Gly 
    50                  55                  60                  


Gln Ser Gln Ala Gln Ser Gln Gly Gln Pro Val Pro Thr Ala Pro Ala 
65                  70                  75                  80  


Arg Ser Arg Ser Ala Lys Arg Arg Lys Met Ala Asp Lys Ile Leu Pro 
                85                  90                  95      


Gln Arg Ile Arg Glu Leu Val Pro Glu Ser Gln Ala Tyr Met Asp Leu 
            100                 105                 110         


Leu Ala Phe Glu Arg Lys Leu Asp Gln Thr Ile Met Arg Lys Arg Val 
        115                 120                 125             


Asp Ile Gln Glu Ala Leu Lys Arg Pro Met Lys Gln Lys Arg Lys Leu 
    130                 135                 140                 


Arg Leu Tyr Ile Ser Asn Thr Phe Asn Pro Ala Lys Pro Asp Ala Glu 
145                 150                 155                 160 


Asp Ser Asp Gly Ser Ile Ala Ser Trp Glu Leu Arg Val Glu Gly Lys 
                165                 170                 175     


Leu Leu Asp Asp Pro Ser Lys Gln Lys Arg Lys Phe Ser Ser Phe Phe 
            180                 185                 190         


Lys Ser Leu Val Ile Glu Leu Asp Lys Asp Leu Tyr Gly Pro Asp Asn 
        195                 200                 205             


His Leu Val Glu Trp His Arg Thr Pro Thr Thr Gln Glu Thr Asp Gly 
    210                 215                 220                 


Phe Gln Val Lys Arg Pro Gly Asp Leu Ser Val Arg Cys Thr Leu Leu 
225                 230                 235                 240 


Leu Met Leu Asp Tyr Gln Pro Pro Gln Phe Lys Leu Asp Pro Arg Leu 
                245                 250                 255     


Ala Arg Leu Leu Gly Leu His Thr Gln Ser Arg Ser Ala Ile Val Gln 
            260                 265                 270         


Ala Leu Trp Gln Tyr Val Lys Thr Asn Arg Leu Gln Asp Ser His Asp 
        275                 280                 285             


Lys Glu Tyr Ile Asn Gly Asp Lys Tyr Phe Gln Gln Ile Phe Asp Cys 
    290                 295                 300                 


Pro Arg Leu Lys Phe Ser Glu Ile Pro Gln Arg Leu Thr Ala Leu Leu 
305                 310                 315                 320 


Leu Pro Pro Asp Pro Ile Val Ile Asn His Val Ile Ser Val Asp Pro 
                325                 330                 335     


Ser Asp Gln Lys Lys Thr Ala Cys Tyr Asp Ile Asp Val Glu Val Glu 
            340                 345                 350         


Glu Pro Leu Lys Gly Gln Met Ser Ser Phe Leu Leu Ser Thr Ala Asn 
        355                 360                 365             


Gln Gln Glu Ile Ser Ala Leu Asp Ser Lys Ile His Glu Thr Ile Glu 
    370                 375                 380                 


Ser Ile Asn Gln Leu Lys Ile Gln Arg Asp Phe Met Leu Ser Phe Ser 
385                 390                 395                 400 


Arg Asp Pro Lys Gly Tyr Val Gln Asp Leu Leu Arg Ser Gln Ser Arg 
                405                 410                 415     


Asp Leu Lys Val Met Thr Asp Val Ala Gly Asn Pro Glu Glu Glu Arg 
            420                 425                 430         


Arg Ala Glu Phe Tyr His Gln Pro Trp Ser Gln Glu Ala Val Ser Arg 
        435                 440                 445             


Tyr Phe Tyr Cys Lys Ile Gln Gln Arg Arg Gln Glu Leu Glu Gln Ser 
    450                 455                 460                 


Leu Val Val Arg Asn Thr 
465                 470 


<210> 96
<211> 1728
<212> DNA
<213> Homo sapiens

<400> 96
gccgggccga gccgagcgcc gagcagggag cgggcggccg cgctccgggc cggggtcccg       60

ggggagcaga tcctcagaat ggcccttggt gctgcaggcg cggtgggctc cgggcccagg      120

caccgagggg gcactggatg actctccagg tgcaggaccc tgccatctat gactccaggt      180

cttcagcacc cacccaccgt ggtacagcgc cccgggatgc cgtctggagc ccggatgccc      240

caccaggggg cgcccatggg ccccccgggc tccccgtaca tgggcagccc cgccgtgcga      300

cccggcctgg cccccgcggg catggagccc gcccgcaagc gagcagcgcc cccgcccggg      360

cagagccagg cacagagcca gggccagccg gtgcccaccg cccccgcgcg gagccgcagt      420

gccaagagga ggaagatggc tgacaaaatc ctccctcaaa ggattcggga gctggtcccc      480

gagtcccagg cttacatgga cctcttggca tttgagagga aactggatca aaccatcatg      540

cggaagcggg tggacatcca ggaggctctg aagaggccca tgaagcaaaa gcggaagctg      600

cgactctata tctccaacac ttttaaccct gcgaagcctg atgctgagga ttccgacggc      660

agcattgcct cctgggagct acgggtggag gggaagctcc tggatgatcc cagcaaacag      720

aagcggaagt tctcttcttt cttcaagagt ttggtcatcg agctggacaa agatctttat      780

ggccctgaca accacctcgt tgagtggcat cggacaccca cgacccagga gacggacggc      840

ttccaggtga aacggcctgg ggacctgagt gtgcgctgca cgctgctcct catgctggac      900

taccagcctc cccagttcaa actggatccc cgcctagccc ggctgctggg gctgcacaca      960

cagagccgct cagccattgt ccaggccctg tggcagtatg tgaagaccaa caggctgcag     1020

gactcccatg acaaggaata catcaatggg gacaagtatt tccagcagat ttttgattgt     1080

ccccggctga agttttctga gattccccag cgcctcacag ccctgctatt gccccctgac     1140

ccaattgtca tcaaccatgt catcagcgtg gacccttcag accagaagaa gacggcgtgc     1200

tatgacattg acgtggaggt ggaggagcca ttaaaggggc agatgagcag cttcctccta     1260

tccacggcca accagcagga gatcagtgct ctggacagta agatccatga gacgattgag     1320

tccataaacc agctcaagat ccagagggac ttcatgctaa gcttctccag agaccccaaa     1380

ggctatgtcc aagacctgct ccgctcccag agccgggacc tcaaggtgat gacagatgta     1440

gccggcaacc ctgaagagga gcgccgggct gagttctacc accagccctg gtcccaggag     1500

gccgtcagtc gctacttcta ctgcaagatc cagcagcgca ggcaggagct ggagcagtcg     1560

ctggttgtgc gcaacaccta ggagcccaaa aataagcagc acgacggaac tttcagccgt     1620

gtcccgggcc ccagcatttt gccccgggct ccagcatcac tcctctgcca ccttggggtg     1680

tggggctgga ttaaaagtca ttcatctgac aaaaaaaaaa aaaaaaaa                  1728


<210> 97
<211> 456
<212> PRT
<213> Homo sapiens

<400> 97
Met Ser Pro Gly Asn Arg Met Pro Met Ala Gly Leu Gln Val Gly Pro 
1               5                   10                  15      


Pro Ala Gly Ser Pro Phe Gly Ala Ala Ala Pro Leu Arg Pro Gly Met 
            20                  25                  30          


Pro Pro Thr Met Met Asp Pro Phe Arg Lys Arg Leu Leu Val Pro Gln 
        35                  40                  45              


Ala Gln Pro Pro Met Pro Ala Gln Arg Arg Gly Leu Lys Arg Arg Lys 
    50                  55                  60                  


Met Ala Asp Lys Val Leu Pro Gln Arg Ile Arg Glu Leu Val Pro Glu 
65                  70                  75                  80  


Ser Gln Ala Tyr Met Asp Leu Leu Ala Phe Glu Arg Lys Leu Asp Gln 
                85                  90                  95      


Thr Ile Ala Arg Lys Arg Met Glu Ile Gln Glu Ala Ile Lys Lys Pro 
            100                 105                 110         


Leu Thr Gln Lys Arg Lys Leu Arg Ile Tyr Ile Ser Asn Thr Phe Ser 
        115                 120                 125             


Pro Ser Lys Ala Glu Gly Asp Ser Ala Gly Thr Ala Gly Thr Pro Gly 
    130                 135                 140                 


Gly Thr Pro Ala Gly Asp Lys Val Ala Ser Trp Glu Leu Arg Val Glu 
145                 150                 155                 160 


Gly Lys Leu Leu Asp Asp Pro Ser Lys Gln Lys Arg Lys Phe Ser Ser 
                165                 170                 175     


Phe Phe Lys Ser Leu Val Ile Glu Leu Asp Lys Glu Leu Tyr Gly Pro 
            180                 185                 190         


Asp Asn His Leu Val Glu Trp His Arg Met Pro Thr Thr Gln Glu Thr 
        195                 200                 205             


Asp Gly Phe Gln Val Lys Arg Pro Gly Asp Leu Asn Val Lys Cys Thr 
    210                 215                 220                 


Leu Leu Leu Met Leu Asp His Gln Pro Pro Gln Tyr Lys Leu Asp Pro 
225                 230                 235                 240 


Arg Leu Ala Arg Leu Leu Gly Val His Thr Gln Thr Arg Ala Ala Ile 
                245                 250                 255     


Met Gln Ala Leu Trp Leu Tyr Ile Lys His Asn Gln Leu Gln Asp Gly 
            260                 265                 270         


His Glu Arg Glu Tyr Ile Asn Cys Asn Arg Tyr Phe Arg Gln Ile Phe 
        275                 280                 285             


Ser Cys Gly Arg Leu Arg Phe Ser Glu Ile Pro Met Lys Leu Ala Gly 
    290                 295                 300                 


Leu Leu Gln His Pro Asp Pro Ile Val Ile Asn His Val Ile Ser Val 
305                 310                 315                 320 


Asp Pro Asn Asp Gln Lys Lys Thr Ala Cys Tyr Asp Ile Asp Val Glu 
                325                 330                 335     


Val Asp Asp Pro Leu Lys Ala Gln Met Ser Asn Phe Leu Ala Ser Thr 
            340                 345                 350         


Thr Asn Gln Gln Glu Ile Ala Ser Leu Asp Val Lys Ile His Glu Thr 
        355                 360                 365             


Ile Glu Ser Ile Asn Gln Leu Lys Thr Gln Arg Asp Phe Met Leu Ser 
    370                 375                 380                 


Phe Ser Thr Asp Pro Gln Asp Phe Ile Gln Glu Trp Leu Arg Ser Gln 
385                 390                 395                 400 


Arg Arg Asp Leu Lys Ile Ile Thr Asp Val Ile Gly Asn Pro Glu Glu 
                405                 410                 415     


Glu Arg Arg Ala Ala Phe Tyr His Gln Pro Trp Ala Gln Glu Ala Val 
            420                 425                 430         


Gly Arg His Ile Phe Ala Lys Val Gln Gln Arg Arg Gln Glu Leu Glu 
        435                 440                 445             


Gln Val Leu Gly Ile Arg Leu Thr 
    450                 455     


<210> 98
<211> 1700
<212> DNA
<213> Homo sapiens

<400> 98
agcaggactc agaggggaga gttggaggaa aaaaaaaggc agaaaaggga aagaaagagg       60

aagagagaga gagagtgaga ggagccgctg agcccacccc gatggccgcg gacgaagttg      120

ccggaggggc gcgcaaagcc acgaaaagca aactttttga gtttctggtc catggggtgc      180

gccccgggat gccgtctgga gcccggatgc cccaccaggg ggcgcccatg ggccccccgg      240

gctccccgta catgggcagc cccgccgtgc gacccggcct ggcccccgcg ggcatggagc      300

ccgcccgcaa gcgagcagcg cccccgcccg ggcagagcca ggcacagagc cagggccagc      360

cggtgcccac cgcccccgcg cggagccgca gtgccaagag gaggaagatg gctgacaaaa      420

tcctccctca aaggattcgg gagctggtcc ccgagtccca ggcttacatg gacctcttgg      480

catttgagag gaaactggat caaaccatca tgcggaagcg ggtggacatc caggaggctc      540

tgaagaggcc catgaagcaa aagcggaagc tgcgactcta tatctccaac acttttaacc      600

ctgcgaagcc tgatgctgag gattccgacg gcagcattgc ctcctgggag ctacgggtgg      660

aggggaagct cctggatgat cccagcaaac agaagcggaa gttctcttct ttcttcaaga      720

gtttggtcat cgagctggac aaagatcttt atggccctga caaccacctc gttgagtggc      780

atcggacacc cacgacccag gagacggacg gcttccaggt gaaacggcct ggggacctga      840

gtgtgcgctg cacgctgctc ctcatgctgg actaccagcc tccccagttc aaactggatc      900

cccgcctagc ccggctgctg gggctgcaca cacagagccg ctcagccatt gtccaggccc      960

tgtggcagta tgtgaagacc aacaggctgc aggactccca tgacaaggaa tacatcaatg     1020

gggacaagta tttccagcag atttttgatt gtccccggct gaagttttct gagattcccc     1080

agcgcctcac agccctgcta ttgccccctg acccaattgt catcaaccat gtcatcagcg     1140

tggacccttc agaccagaag aagacggcgt gctatgacat tgacgtggag gtggaggagc     1200

cattaaaggg gcagatgagc agcttcctcc tatccacggc caaccagcag gagatcagtg     1260

ctctggacag taagatccat gagacgattg agtccataaa ccagctcaag atccagaggg     1320

acttcatgct aagcttctcc agagacccca aaggctatgt ccaagacctg ctccgctccc     1380

agagccggga cctcaaggtg atgacagatg tagccggcaa ccctgaagag gagcgccggg     1440

ctgagttcta ccaccagccc tggtcccagg aggccgtcag tcgctacttc tactgcaaga     1500

tccagcagcg caggcaggag ctggagcagt cgctggttgt gcgcaacacc taggagccca     1560

aaaataagca gcacgacgga actttcagcc gtgtcccggg ccccagcatt ttgccccggg     1620

ctccagcatc actcctctgc caccttgggg tgtggggctg gattaaaagt cattcatctg     1680

acaaaaaaaa aaaaaaaaaa                                                 1700


<210> 99
<211> 1743
<212> DNA
<213> Mus musculus

<400> 99
gggccccctc cccactccgc tcgagtagaa gtgtgagaga gcccagcagg actcagaggg       60

gagagttgga ggaaaaaaaa ggcagaaaag ggaaagaaag aggaagagag agagagagtg      120

agaggagccg ctgagcccac cccgatggcc gcggacgaag ttgccggagg ggcgcgcaaa      180

gccacgaaaa gcaaactttt tgagtttctg gtccatgggg tgcgccccgg gatgccgtct      240

ggagcccgaa tgccccacca gggggcgccc atgggccccc cgggctcccc gtacatgggc      300

agccccgcgg tacgacccgg cctggccccc gcgggcatgg agcccgcccg caagcgagca      360

gcgcccccgc ccgggcagag ccaggcacag ggccagggcc agcccgtgcc caccgcccca      420

gcgcggagcc gcagtgccaa gaggaggaag atggctgaca aaatcctccc tcaaaggatt      480

cgggagctgg tacccgagtc ccaggcttac atggacctcc tagcatttga gaggaaactg      540

gatcaaacca tcatgcggaa gcgggtggac atccaggagg ccctgaagag gcccatgaag      600

caaaagcgaa agctgcgcct ttatatctcc aatactttta accctgcgaa gcctgatgcg      660

gaagactctg atggcagcat tgcctcctgg gagctgcggg tggaggggaa gctcttggat      720

gatcctagta agcagaagag gaagttttct tccttcttca agagtttggt cattgagttg      780

gacaaagacc tttatggccc agacaaccac cttgttgagt ggcaccggac acccacaacc      840

caggaaacag atgggttcca agtgaagaga ccaggggact tgagtgtgcg ctgcaccctg      900

ctcctgatgc tggactatca gcctccccag ttcaaattgg acccccgctt agcccggctg      960

ctggggttac acacacagag ccgctcagcc attgtccagg cactgtggca gtatgtgaag     1020

accaacaggc tacaggactc ccatgacaag gagtacatca atggcgacaa gtatttccag     1080

cagatttttg actgcccccg cctaaagttc tctgagattc cccagcgcct cacagccctg     1140

ctgctgcccc ctgaccccat tgtgatcaac cacgtcatca gcgtggaccc atcagaccag     1200

aagaagacag cgtgctatga catagatgtg gaggtggagg aaccgctgaa agggcagatg     1260

agtagcttcc tcctgtccac ggccaaccag caggagatca gtgctctgga cagtaagatc     1320

catgagacga ttgagtccat aaaccagctc aagatccaga gggacttcat gctaagtttc     1380

tccagagacc ccaaaggcta cgtccaagac ctgctccgct cccagagccg tgatctcaag     1440

gtgatgacag atgtggcagg gaaccccgag gaagaacgca gggctgagtt ctaccaccag     1500

ccctggtccc aggaagccgt tagccgctac ttctactgta agatccagca gcgcaggcag     1560

gagctggagc agtcgctggt cgtgcgcaac acctaggagc ccgtgaacaa gcgtcagggt     1620

ggaccagcca ctccgcccag cacaggccct gggctctgga ctccccctct cgcgctgtgc     1680

ggaaggtggg gagggctgga tggattaaag gtcacgtaac agacaaaaaa aaaaaaaaaa     1740

aaa                                                                   1743


<210> 100
<211> 483
<212> PRT
<213> Mus musculus

<400> 100
Met Ala Ala Asp Glu Val Ala Gly Gly Ala Arg Lys Ala Thr Lys Ser 
1               5                   10                  15      


Lys Leu Phe Glu Phe Leu Val His Gly Val Arg Pro Gly Met Pro Ser 
            20                  25                  30          


Gly Ala Arg Met Pro His Gln Gly Ala Pro Met Gly Pro Pro Gly Ser 
        35                  40                  45              


Pro Tyr Met Gly Ser Pro Ala Val Arg Pro Gly Leu Ala Pro Ala Gly 
    50                  55                  60                  


Met Glu Pro Ala Arg Lys Arg Ala Ala Pro Pro Pro Gly Gln Ser Gln 
65                  70                  75                  80  


Ala Gln Gly Gln Gly Gln Pro Val Pro Thr Ala Pro Ala Arg Ser Arg 
                85                  90                  95      


Ser Ala Lys Arg Arg Lys Met Ala Asp Lys Ile Leu Pro Gln Arg Ile 
            100                 105                 110         


Arg Glu Leu Val Pro Glu Ser Gln Ala Tyr Met Asp Leu Leu Ala Phe 
        115                 120                 125             


Glu Arg Lys Leu Asp Gln Thr Ile Met Arg Lys Arg Val Asp Ile Gln 
    130                 135                 140                 


Glu Ala Leu Lys Arg Pro Met Lys Gln Lys Arg Lys Leu Arg Leu Tyr 
145                 150                 155                 160 


Ile Ser Asn Thr Phe Asn Pro Ala Lys Pro Asp Ala Glu Asp Ser Asp 
                165                 170                 175     


Gly Ser Ile Ala Ser Trp Glu Leu Arg Val Glu Gly Lys Leu Leu Asp 
            180                 185                 190         


Asp Pro Ser Lys Gln Lys Arg Lys Phe Ser Ser Phe Phe Lys Ser Leu 
        195                 200                 205             


Val Ile Glu Leu Asp Lys Asp Leu Tyr Gly Pro Asp Asn His Leu Val 
    210                 215                 220                 


Glu Trp His Arg Thr Pro Thr Thr Gln Glu Thr Asp Gly Phe Gln Val 
225                 230                 235                 240 


Lys Arg Pro Gly Asp Leu Ser Val Arg Cys Thr Leu Leu Leu Met Leu 
                245                 250                 255     


Asp Tyr Gln Pro Pro Gln Phe Lys Leu Asp Pro Arg Leu Ala Arg Leu 
            260                 265                 270         


Leu Gly Leu His Thr Gln Ser Arg Ser Ala Ile Val Gln Ala Leu Trp 
        275                 280                 285             


Gln Tyr Val Lys Thr Asn Arg Leu Gln Asp Ser His Asp Lys Glu Tyr 
    290                 295                 300                 


Ile Asn Gly Asp Lys Tyr Phe Gln Gln Ile Phe Asp Cys Pro Arg Leu 
305                 310                 315                 320 


Lys Phe Ser Glu Ile Pro Gln Arg Leu Thr Ala Leu Leu Leu Pro Pro 
                325                 330                 335     


Asp Pro Ile Val Ile Asn His Val Ile Ser Val Asp Pro Ser Asp Gln 
            340                 345                 350         


Lys Lys Thr Ala Cys Tyr Asp Ile Asp Val Glu Val Glu Glu Pro Leu 
        355                 360                 365             


Lys Gly Gln Met Ser Ser Phe Leu Leu Ser Thr Ala Asn Gln Gln Glu 
    370                 375                 380                 


Ile Ser Ala Leu Asp Ser Lys Ile His Glu Thr Ile Glu Ser Ile Asn 
385                 390                 395                 400 


Gln Leu Lys Ile Gln Arg Asp Phe Met Leu Ser Phe Ser Arg Asp Pro 
                405                 410                 415     


Lys Gly Tyr Val Gln Asp Leu Leu Arg Ser Gln Ser Arg Asp Leu Lys 
            420                 425                 430         


Val Met Thr Asp Val Ala Gly Asn Pro Glu Glu Glu Arg Arg Ala Glu 
        435                 440                 445             


Phe Tyr His Gln Pro Trp Ser Gln Glu Ala Val Ser Arg Tyr Phe Tyr 
    450                 455                 460                 


Cys Lys Ile Gln Gln Arg Arg Gln Glu Leu Glu Gln Ser Leu Val Val 
465                 470                 475                 480 


Arg Asn Thr 
            


<210> 101
<211> 2425
<212> DNA
<213> Homo sapiens

<400> 101
gctccggacg cgaggggcgg ggcgagcgcg ggacaaaggg aagcgaagcc ggagctgcgg       60

gcgctttttc tgcccgcggt gtctcagatt cattcttaag gaactgagaa cttaatcttc      120

caaaatgtca aaaagaccat cttatgcccc acctcccacc ccagctcctg caacacaaat      180

gcccagcaca ccagggtttg tgggatacaa tccatacagt catctcgcct acaacaacta      240

caggctggga gggaacccgg gcaccaacag ccgggtcacg gcatcctctg gtatcacgat      300

tccaaaaccc ccaaagccac cagataagcc gctgatgccc tacatgaggt acagcagaaa      360

ggtctgggac caagtaaagg cttccaaccc tgacctaaag ttgtgggaga ttggcaagat      420

tattggtggc atgtggcgag atctcactga tgaagaaaaa caagaatatt taaacgaata      480

cgaagcagaa aagatagagt acaatgaatc tatgaaggcc tatcataatt cccccgcgta      540

ccttgcttac ataaatgcaa aaagtcgtgc agaagctgct ttagaggaag aaagtcgaca      600

gagacaatct cgcatggaga aaggagaacc gtacatgagc attcagcctg ctgaagatcc      660

agatgattat gatgatggct tttcaatgaa gcatacagcc accgcccgtt tccagagaaa      720

ccaccgcctc atcagtgaaa ttcttagtga gagtgtggtg ccagacgttc ggtcagttgt      780

cacaacagct agaatgcagg tcctcaaacg gcaggtccag tccttaatgg ttcatcagcg      840

aaaactagaa gctgaacttc ttcaaataga ggaacgacac caggagaaga agaggaaatt      900

cctggaaagc acagattcat ttaacaatga acttaaaagg ttgtgcggtc tgaaagtaga      960

agtggatatg gagaaaattg cagctgagat tgcacaggca gaggaacagg cccgcaaaag     1020

gcaggaggaa agggagaagg aggccgcaga gcaagctgag cgcagtcaga gcagcatcgt     1080

tcctgaggaa gaacaagcag ctaacaaagg cgaggagaag aaagacgacg agaacattcc     1140

gatggagaca gaggagacac accttgaaga aacaacagag agccaacaga atggtgaaga     1200

aggcacgtct actcctgagg acaaggagag tgggcaggag ggggtcgaca gtatggcaga     1260

ggaaggaacc agtgatagta acactggctc ggagagcaac agtgcaacag tggaggagcc     1320

accaacagat cccataccag aagatgagaa aaaagaataa gtgttgcctt gttttgtgtg     1380

ttctaaatac tttttttaat gaaaaaatgt tttttggttt taatggtgtt acgtggtttg     1440

tgtattaatt ttttttcttg tccatatcac accaccaaag gcttttggac catttagcat     1500

catgagccta atggctcagt cagtcacctt tcttaagtgt tgtgaagatg gctcttttct     1560

ttggatcttg tttctagccc tcaactgctg aaagcctcag aatttagatt aattgagaaa     1620

acacccacct cttttagaga attatccttt gatgctgcag aatctactct tacaatgcct     1680

tcctacagct cactggggtg cttaccaaag ccatagcttt aaaccttccc agtccccatc     1740

agtagcttcc tgaaagtctc ctctcttgtt tacttctgca aagggtagct tcttaaaaac     1800

gtgatcatgt atgagtatgt atttgttcac ttaccctttt ttacttttaa tcaatgtcag     1860

ataccaagag ttgtgttaag ctgagtgtag tgtgtaacta actacacttg gatcttactg     1920

atccagaaat agtccccata gttagagtag ttacttatga agtggttatt aaagtgaaca     1980

cagcacatat acattatcta tactgctttt tgttatgatt aatactgggt atgttctggt     2040

aaatccatcc ttattgtata gaaaaaaaat tactttttta ccaggttttc caaagacaga     2100

atagatcaca aagctcaagg aatttaatat tcttgtaatg gactagataa ttcaaactga     2160

ttagcccatt ccagaagaaa aacagctggg aattaagtta atccacttga aattgtttta     2220

caataatcag aacatccaaa cctcaaggct caggatccca tagaccagag cccacctttt     2280

tgataaactt agtaaagtct tggagactag aagcaagata gtttgtgaca cataagcttc     2340

ccaaaaacta gaatagattt ttactgaata gtggtatatc tgatggtata tgtttcttaa     2400

aggtccaaat gtaataaaaa aaaaa                                           2425


<210> 102
<211> 411
<212> PRT
<213> Homo sapiens

<400> 102
Met Ser Lys Arg Pro Ser Tyr Ala Pro Pro Pro Thr Pro Ala Pro Ala 
1               5                   10                  15      


Thr Gln Met Pro Ser Thr Pro Gly Phe Val Gly Tyr Asn Pro Tyr Ser 
            20                  25                  30          


His Leu Ala Tyr Asn Asn Tyr Arg Leu Gly Gly Asn Pro Gly Thr Asn 
        35                  40                  45              


Ser Arg Val Thr Ala Ser Ser Gly Ile Thr Ile Pro Lys Pro Pro Lys 
    50                  55                  60                  


Pro Pro Asp Lys Pro Leu Met Pro Tyr Met Arg Tyr Ser Arg Lys Val 
65                  70                  75                  80  


Trp Asp Gln Val Lys Ala Ser Asn Pro Asp Leu Lys Leu Trp Glu Ile 
                85                  90                  95      


Gly Lys Ile Ile Gly Gly Met Trp Arg Asp Leu Thr Asp Glu Glu Lys 
            100                 105                 110         


Gln Glu Tyr Leu Asn Glu Tyr Glu Ala Glu Lys Ile Glu Tyr Asn Glu 
        115                 120                 125             


Ser Met Lys Ala Tyr His Asn Ser Pro Ala Tyr Leu Ala Tyr Ile Asn 
    130                 135                 140                 


Ala Lys Ser Arg Ala Glu Ala Ala Leu Glu Glu Glu Ser Arg Gln Arg 
145                 150                 155                 160 


Gln Ser Arg Met Glu Lys Gly Glu Pro Tyr Met Ser Ile Gln Pro Ala 
                165                 170                 175     


Glu Asp Pro Asp Asp Tyr Asp Asp Gly Phe Ser Met Lys His Thr Ala 
            180                 185                 190         


Thr Ala Arg Phe Gln Arg Asn His Arg Leu Ile Ser Glu Ile Leu Ser 
        195                 200                 205             


Glu Ser Val Val Pro Asp Val Arg Ser Val Val Thr Thr Ala Arg Met 
    210                 215                 220                 


Gln Val Leu Lys Arg Gln Val Gln Ser Leu Met Val His Gln Arg Lys 
225                 230                 235                 240 


Leu Glu Ala Glu Leu Leu Gln Ile Glu Glu Arg His Gln Glu Lys Lys 
                245                 250                 255     


Arg Lys Phe Leu Glu Ser Thr Asp Ser Phe Asn Asn Glu Leu Lys Arg 
            260                 265                 270         


Leu Cys Gly Leu Lys Val Glu Val Asp Met Glu Lys Ile Ala Ala Glu 
        275                 280                 285             


Ile Ala Gln Ala Glu Glu Gln Ala Arg Lys Arg Gln Glu Glu Arg Glu 
    290                 295                 300                 


Lys Glu Ala Ala Glu Gln Ala Glu Arg Ser Gln Ser Ser Ile Val Pro 
305                 310                 315                 320 


Glu Glu Glu Gln Ala Ala Asn Lys Gly Glu Glu Lys Lys Asp Asp Glu 
                325                 330                 335     


Asn Ile Pro Met Glu Thr Glu Glu Thr His Leu Glu Glu Thr Thr Glu 
            340                 345                 350         


Ser Gln Gln Asn Gly Glu Glu Gly Thr Ser Thr Pro Glu Asp Lys Glu 
        355                 360                 365             


Ser Gly Gln Glu Gly Val Asp Ser Met Ala Glu Glu Gly Thr Ser Asp 
    370                 375                 380                 


Ser Asn Thr Gly Ser Glu Ser Asn Ser Ala Thr Val Glu Glu Pro Pro 
385                 390                 395                 400 


Thr Asp Pro Ile Pro Glu Asp Glu Lys Lys Glu 
                405                 410     


<210> 103
<211> 2961
<212> DNA
<213> Mus musculus

<400> 103
ggcggaggca ggggagcccc gctgggcgcc agcaaggacc taaacgcagc gacccgggtc       60

ctccccgcct acattctcca tcttctccat tcatacgtcc atcagcggag gactgaagac      120

cagagcgaag ggaaaagcca gagtgcatgg tgtgtgggaa ctgcgtccca ccctctcccg      180

ggagaggctc cggcgagcct ttcccctccg gcgcccgcct cacgcggcgg cgcccaccgc      240

ctcagtgaag ccccgggcgc gcagtctgcg cagttcctgc cgccgggccg cgaaccaggg      300

cccgcaacgc ggcccagcct tctccgccct cctcgccgtg acgaatcggc gcccgactgg      360

gacgggatcc aaattggaag acttctgagg aaacccagga gcctgacgaa atttttttta      420

aaaatccttg gcgccctaag cctcgccgcg tgctcactgg aagggctgtt cgtctgccgg      480

gagccggccg cggccggcag acaattcccg ggagcgtgtg gaaagtgcga gcgcggaagc      540

tccggcgcga ggggcggggc gagcgcggga caaagggaag cgaagccgga gctgcgggcg      600

cctgctcggc ccgcggtgtc tcagattcat tcttaaggaa ctgagaactt aatcttccaa      660

aatgtcaaaa agaccatctt atgccccacc tcccacccca gctcctgcaa cacaaatgcc      720

cagcacacca gggtttgtgg gatacaatcc atacagtcat ctcgcctaca acaactacag      780

gctgggaggg aacccgggca ccaacagccg ggtcacggcg tcctctggca ttacgattcc      840

aaagcctcca aagccaccag ataagccgct gatgccctac atgaggtaca gcagaaaggt      900

ctgggaccaa gtaaaggctt ccaaccctga cctaaagttg tgggagattg gcaagattat      960

tggtggcatg tggcgagatc tcactgatga agagaagcaa gaatatttaa acgaatacga     1020

agcagaaaag atagagtaca atgagtctat gaaggcctac cataattccc ctgcgtacct     1080

tgcctatatt aatgcaaaaa gtcgtgcgga agctgcatta gaggaagaaa gtcgacagag     1140

acagtctcgc atggagaaag gagaacctta catgagcatt cagcctgctg aggatccaga     1200

cgactatgat gatggctttt caatgaagca cacagccact gcccgtttcc agagaaacca     1260

ccgtctcatc agtgagatcc tcagtgagag tgtggtacct gatgtgcggt cggttgtcac     1320

aacagctaga atgcaggtcc tcaagcgaca ggtccagtct ttaatggttc atcagcggaa     1380

actagaagcc gagctccttc agatagagga acgacaccag gaaaagaaga ggaaattcct     1440

ggaaagcacg gactccttta acaatgaact taaaaggtta tgtggtctga aggtggaagt     1500

agacatggag aagattgcgg ctgagatcgc acaggcggag gaacaagccc gcaagaggca     1560

agaggagagg gagaaggagg cagcagagca ggctgagcgc agtcagagca gcatggcccc     1620

tgaggaagag caagtggcga acaaagccga ggagaagaaa gatgaggaga gcatcccgat     1680

ggagacagag gagacacacc ttgaagacac agcagagagc cagcagaatg gtgaagaagg     1740

cacgtctact cctgaggaca aggagagtgg gcaggagggg gttgacagca tggaggtgga     1800

agggaccagt gacagtaaca cgggctcaga gagcaacagc gccacagtgg aggagccgcc     1860

cacagaccca gtgccagaag acgagaagaa ggagtaaatg ttgccttgtt ttatgtgacc     1920

taaaactttt ttaaatgaaa aaaaaatgtg gttttttttt tggttttaat ggtgttatgt     1980

ggtctgtgta ttaattattt acttttccgt tgatacaaca tgaaggtctt tgaaccctca     2040

gcatcatagc ctaatgccag ccgctcacct ttcttagctc tcaacgtctg aaacctcaga     2100

gctgagatta atcaagacac ccatcattct ctgagaacta ccttggctgc tgcagaatcg     2160

actcttccaa atacctgcct tcagctcacg tggtgctcac caaagccata gctttaaacc     2220

cttccagccc atccacagct ttcccagtcc ctgtcttgtg tacttacaca gagtgccctc     2280

ttgaaatcat gagggggtct cttcactcac cctttctatg tcccatgtca gacaccagga     2340

gttctcttac agggtagggt gtagccagaa actggtgaga cacagatcac agagatgcct     2400

ctgggggcac tgggggtggg ggagcagggg gagtacagtt gttctttctg tggattcctt     2460

gttggtgaga gctgcgcctg cttatctaga gtgctgttca gtgtagtcga tctgggatgt     2520

gttctgggaa attcatcctt tttgtacagg ggaaagaaac actttttttt accagattgg     2580

ctttccaaag acacgataga tggcagagct taaggaatgg aatgttctta taatggacta     2640

cagacttcaa agtgattggc ccattccaaa aggaaaatgg gaatgctgtt catccatgtg     2700

agcatacttc acagtgatga aaacctcaag actcgagatc ccatagatca gagccgaacc     2760

tacttttttg ataacccctg tagtggtctt agagactaga aacaagatag tttgtagtgt     2820

gtgctcccta aaatctagaa tagattttta ctgaatagtg gtatatatga tggtatatgt     2880

ttcttaaagg tccaaacata ataaagaaat taagacaaaa aaaaaaaaaa aaaaaaaaaa     2940

aaaaaaaaaa aaaaaaaaaa a                                               2961


<210> 104
<211> 411
<212> PRT
<213> Mus musculus

<400> 104
Met Ser Lys Arg Pro Ser Tyr Ala Pro Pro Pro Thr Pro Ala Pro Ala 
1               5                   10                  15      


Thr Gln Met Pro Ser Thr Pro Gly Phe Val Gly Tyr Asn Pro Tyr Ser 
            20                  25                  30          


His Leu Ala Tyr Asn Asn Tyr Arg Leu Gly Gly Asn Pro Gly Thr Asn 
        35                  40                  45              


Ser Arg Val Thr Ala Ser Ser Gly Ile Thr Ile Pro Lys Pro Pro Lys 
    50                  55                  60                  


Pro Pro Asp Lys Pro Leu Met Pro Tyr Met Arg Tyr Ser Arg Lys Val 
65                  70                  75                  80  


Trp Asp Gln Val Lys Ala Ser Asn Pro Asp Leu Lys Leu Trp Glu Ile 
                85                  90                  95      


Gly Lys Ile Ile Gly Gly Met Trp Arg Asp Leu Thr Asp Glu Glu Lys 
            100                 105                 110         


Gln Glu Tyr Leu Asn Glu Tyr Glu Ala Glu Lys Ile Glu Tyr Asn Glu 
        115                 120                 125             


Ser Met Lys Ala Tyr His Asn Ser Pro Ala Tyr Leu Ala Tyr Ile Asn 
    130                 135                 140                 


Ala Lys Ser Arg Ala Glu Ala Ala Leu Glu Glu Glu Ser Arg Gln Arg 
145                 150                 155                 160 


Gln Ser Arg Met Glu Lys Gly Glu Pro Tyr Met Ser Ile Gln Pro Ala 
                165                 170                 175     


Glu Asp Pro Asp Asp Tyr Asp Asp Gly Phe Ser Met Lys His Thr Ala 
            180                 185                 190         


Thr Ala Arg Phe Gln Arg Asn His Arg Leu Ile Ser Glu Ile Leu Ser 
        195                 200                 205             


Glu Ser Val Val Pro Asp Val Arg Ser Val Val Thr Thr Ala Arg Met 
    210                 215                 220                 


Gln Val Leu Lys Arg Gln Val Gln Ser Leu Met Val His Gln Arg Lys 
225                 230                 235                 240 


Leu Glu Ala Glu Leu Leu Gln Ile Glu Glu Arg His Gln Glu Lys Lys 
                245                 250                 255     


Arg Lys Phe Leu Glu Ser Thr Asp Ser Phe Asn Asn Glu Leu Lys Arg 
            260                 265                 270         


Leu Cys Gly Leu Lys Val Glu Val Asp Met Glu Lys Ile Ala Ala Glu 
        275                 280                 285             


Ile Ala Gln Ala Glu Glu Gln Ala Arg Lys Arg Gln Glu Glu Arg Glu 
    290                 295                 300                 


Lys Glu Ala Ala Glu Gln Ala Glu Arg Ser Gln Ser Ser Met Ala Pro 
305                 310                 315                 320 


Glu Glu Glu Gln Val Ala Asn Lys Ala Glu Glu Lys Lys Asp Glu Glu 
                325                 330                 335     


Ser Ile Pro Met Glu Thr Glu Glu Thr His Leu Glu Asp Thr Ala Glu 
            340                 345                 350         


Ser Gln Gln Asn Gly Glu Glu Gly Thr Ser Thr Pro Glu Asp Lys Glu 
        355                 360                 365             


Ser Gly Gln Glu Gly Val Asp Ser Met Glu Val Glu Gly Thr Ser Asp 
    370                 375                 380                 


Ser Asn Thr Gly Ser Glu Ser Asn Ser Ala Thr Val Glu Glu Pro Pro 
385                 390                 395                 400 


Thr Asp Pro Val Pro Glu Asp Glu Lys Lys Glu 
                405                 410     


<210> 105
<211> 2348
<212> DNA
<213> Homo sapiens

<400> 105
gtgctcccgc cccccgggaa tgaatggatg ggcggcctca gcgcccgccc gaccgctggg       60

aggaccgacc cggcggggac ctgctggggg caggacccgg ggagcaagat ggccactgtc      120

atccctggcc ccctgagcct aggcgaggac ttctaccgcg aggccatcga gcactgccgc      180

agttacaacg cgcgcctgtg cgccgagcgc agcctgcgac tgcccttcct cgactcgcag      240

accggcgtgg cccagaacaa ctgctacatc tggatggaga agacccaccg cgggccgggt      300

ttggccccgg gacagattta cacgtacccc gcccgctgtt ggaggaagaa acggagactc      360

aacatcctgg aggaccccag actcaggccc tgcgagtaca agatcgactg tgaagcaccc      420

ctgaagaagg agggtggcct cccggaaggg ccggtcctcg aggctctact gtgtgcagag      480

acgggggaga agaagattga gctgaaggag gaggagacca ttatggactg tcagaaacag      540

cagttgctgg agtttccgca tgacctcgag gtggaagact tggaggatga cattcccagg      600

aggaagaaca gggccaaagg aaaggcatat ggcatcgggg gtctccggaa acgccaggac      660

accgcttccc tggaggaccg agacaagccg tatgtctgtg atatctgtgg gaaacggtat      720

aagaaccggc cggggctcag ctaccactac acccacaccc acctggccga ggaggagggg      780

gaggagaacg ccgaacgcca cgccctgccc ttccaccgga aaaacaacca taaacagttt      840

tacaaagaat tggcctgggt ccctgaggca caaaggaaac acacagccaa gaaggcgccc      900

gacggcactg tcatccccaa cggctactgt gacttctgcc tggggggctc caagaagacg      960

gggtgtcccg aggacctcat ctcctgtgcg gactgtgggc gatcaggaca cccctcgtgt     1020

ttacaattca cggtgaacat gacggcagcc gtgcggacct accgctggca gtgcatcgag     1080

tgcaaatcct gcagcctgtg cggaacctcc gagaacgacg accagctgct gttttgtgat     1140

gactgcgatc ggggttacca catgtactgc ctgagtcccc ccatggcgga gcccccggaa     1200

gggagctgga gctgtcacct ctgtctccgg cacctgaagg aaaaggcttc tgcttacatc     1260

accctcacct aggccggctc ggctcgccgc gactctgggg tggtgctcgc ctacctgcct     1320

ctccgagctc ctcaattctc ccccaccctg aacatcccgc agggggaggg ggagaggggg     1380

aagccgagag ggggctgggc caccccctcc cctctgtgca agtggaatgt ctgccctgtg     1440

ggtgggtggg cccggccagg gcctctccct ccctccctcc ctctctgtcc cttggcaaat     1500

ggacaccagg ggcttctccc ctcaaagcca taccccgcct ctgggcgggc atggggggtg     1560

gtgggtgcca gccaggggca tggacagagc ctttttctaa agaaaaagac aaaaagttaa     1620

aaaaaaaaaa aagaagaaaa gaaaagaagt taatatatac aaagagtcct ccaaggcctg     1680

gctgggtgga ggggcgctgc tgagagtgtc caccgggcac ccgcctctgc cggccccccg     1740

ccgggcgccc caaccccaat ttctggagct gcagccgtcc cgcgccccac ccaaggtggg     1800

cgccttcccc tcttgtgccc agggcggtgg gcgtggtgtc cacccgcccc tcctggtgcc     1860

cacggtggat actgcatgat gtgaaccttg gttttgaact ctgttcctgc ccctccccga     1920

ccgccccagc ctgtgcccgc cccgtgcctg ccgtggctgg tgggtggcgg tggtggggcc     1980

gggtgggccc ccgcccagcg cctgctggaa tgagaagcac agactccgcc acggactcct     2040

tttctctccc tcctcccgcc ccgccaggcc tggcggcccc cgcccccctc gctggccatt     2100

ttgggggagt gagggggcgt ggttgtttct tgtggttgtg tgtgtttgtt gttcgggttt     2160

taaaaaaggg aaactgagac tgcaggtggg ggaggtggtg ggttttgggg ggatgtcccc     2220

taatccagga gtgccccctc acttgtcacc gagtctcctc tattgcctgc ctctgctgtg     2280

aattaacttg ttctgtgtat taaactgggc ctgacccctc tgcccacgaa aaaaaaaaaa     2340

aaaaaaaa                                                              2348


<210> 106
<211> 414
<212> PRT
<213> Homo sapiens

<400> 106
Met Gly Gly Leu Ser Ala Arg Pro Thr Ala Gly Arg Thr Asp Pro Ala 
1               5                   10                  15      


Gly Thr Cys Trp Gly Gln Asp Pro Gly Ser Lys Met Ala Thr Val Ile 
            20                  25                  30          


Pro Gly Pro Leu Ser Leu Gly Glu Asp Phe Tyr Arg Glu Ala Ile Glu 
        35                  40                  45              


His Cys Arg Ser Tyr Asn Ala Arg Leu Cys Ala Glu Arg Ser Leu Arg 
    50                  55                  60                  


Leu Pro Phe Leu Asp Ser Gln Thr Gly Val Ala Gln Asn Asn Cys Tyr 
65                  70                  75                  80  


Ile Trp Met Glu Lys Thr His Arg Gly Pro Gly Leu Ala Pro Gly Gln 
                85                  90                  95      


Ile Tyr Thr Tyr Pro Ala Arg Cys Trp Arg Lys Lys Arg Arg Leu Asn 
            100                 105                 110         


Ile Leu Glu Asp Pro Arg Leu Arg Pro Cys Glu Tyr Lys Ile Asp Cys 
        115                 120                 125             


Glu Ala Pro Leu Lys Lys Glu Gly Gly Leu Pro Glu Gly Pro Val Leu 
    130                 135                 140                 


Glu Ala Leu Leu Cys Ala Glu Thr Gly Glu Lys Lys Ile Glu Leu Lys 
145                 150                 155                 160 


Glu Glu Glu Thr Ile Met Asp Cys Gln Lys Gln Gln Leu Leu Glu Phe 
                165                 170                 175     


Pro His Asp Leu Glu Val Glu Asp Leu Glu Asp Asp Ile Pro Arg Arg 
            180                 185                 190         


Lys Asn Arg Ala Lys Gly Lys Ala Tyr Gly Ile Gly Gly Leu Arg Lys 
        195                 200                 205             


Arg Gln Asp Thr Ala Ser Leu Glu Asp Arg Asp Lys Pro Tyr Val Cys 
    210                 215                 220                 


Asp Ile Cys Gly Lys Arg Tyr Lys Asn Arg Pro Gly Leu Ser Tyr His 
225                 230                 235                 240 


Tyr Thr His Thr His Leu Ala Glu Glu Glu Gly Glu Glu Asn Ala Glu 
                245                 250                 255     


Arg His Ala Leu Pro Phe His Arg Lys Asn Asn His Lys Gln Phe Tyr 
            260                 265                 270         


Lys Glu Leu Ala Trp Val Pro Glu Ala Gln Arg Lys His Thr Ala Lys 
        275                 280                 285             


Lys Ala Pro Asp Gly Thr Val Ile Pro Asn Gly Tyr Cys Asp Phe Cys 
    290                 295                 300                 


Leu Gly Gly Ser Lys Lys Thr Gly Cys Pro Glu Asp Leu Ile Ser Cys 
305                 310                 315                 320 


Ala Asp Cys Gly Arg Ser Gly His Pro Ser Cys Leu Gln Phe Thr Val 
                325                 330                 335     


Asn Met Thr Ala Ala Val Arg Thr Tyr Arg Trp Gln Cys Ile Glu Cys 
            340                 345                 350         


Lys Ser Cys Ser Leu Cys Gly Thr Ser Glu Asn Asp Asp Gln Leu Leu 
        355                 360                 365             


Phe Cys Asp Asp Cys Asp Arg Gly Tyr His Met Tyr Cys Leu Ser Pro 
    370                 375                 380                 


Pro Met Ala Glu Pro Pro Glu Gly Ser Trp Ser Cys His Leu Cys Leu 
385                 390                 395                 400 


Arg His Leu Lys Glu Lys Ala Ser Ala Tyr Ile Thr Leu Thr 
                405                 410                 


<210> 107
<211> 2246
<212> DNA
<213> Homo sapiens

<400> 107
gtgctcccgc cccccgggaa tgaatggatg ggcggcctca gcgcccgccc gaccgctggg       60

aggaccgacc cggcggggac ctgctggggg caggacccgg ggagcaagat ggccactgtc      120

atccctggcc ccctgagcct aggcgaggac ttctaccgcg aggccatcga gcactgccgc      180

agttacaacg cgcgcctgtg cgccgagcgc agcctgcgac tgcccttcct cgactcgcag      240

accggcgtgg cccagaacaa ctgctacatc tggatggaga agacccaccg cgggccgggt      300

ttggccccgg gacagattta cacgtacccc gcccgctgtt ggaggaagaa acggagactc      360

aacatcctgg aggaccccag actcaggccc tgcgagtaca agatcgactg tgaagcaccc      420

ctgaagaagg agggtggcct cccggaaggg ccggtcctcg aggctctact gtgtgcagag      480

acgggggaga agaagattga gctgaaggag gaggagacca ttatggactg tcagaaacag      540

cagttgctgg agtttccgca tgacctcgag gtggaagact tggaggatga cattcccagg      600

aggaagaaca gggccaaagg aaaggcatat ggcatcgggg gtctccggaa acgccaggac      660

accgcttccc tggaggaccg agacaagccg tatgtctgtg ataagtttta caaagaattg      720

gcctgggtcc ctgaggcaca aaggaaacac acagccaaga aggcgcccga cggcactgtc      780

atccccaacg gctactgtga cttctgcctg gggggctcca agaagacggg gtgtcccgag      840

gacctcatct cctgtgcgga ctgtgggcga tcaggacacc cctcgtgttt acaattcacg      900

gtgaacatga cggcagccgt gcggacctac cgctggcagt gcatcgagtg caaatcctgc      960

agcctgtgcg gaacctccga gaacgacggt gccagctggg cgggtctcac cccccaggac     1020

cagctgctgt tttgtgatga ctgcgatcgg ggttaccaca tgtactgcct gagtcccccc     1080

atggcggagc ccccggaagg gagctggagc tgtcacctct gtctccggca cctgaaggaa     1140

aaggcttctg cttacatcac cctcacctag gccggctcgg ctcgccgcga ctctggggtg     1200

gtgctcgcct acctgcctct ccgagctcct caattctccc ccaccctgaa catcccgcag     1260

ggggaggggg agagggggaa gccgagaggg ggctgggcca ccccctcccc tctgtgcaag     1320

tggaatgtct gccctgtggg tgggtgggcc cggccagggc ctctccctcc ctccctccct     1380

ctctgtccct tggcaaatgg acaccagggg cttctcccct caaagccata ccccgcctct     1440

gggcgggcat ggggggtggt gggtgccagc caggggcatg gacagagcct ttttctaaag     1500

aaaaagacaa aaagttaaaa aaaaaaaaaa gaagaaaaga aaagaagtta atatatacaa     1560

agagtcctcc aaggcctggc tgggtggagg ggcgctgctg agagtgtcca ccgggcaccc     1620

gcctctgccg gccccccgcc gggcgcccca accccaattt ctggagctgc agccgtcccg     1680

cgccccaccc aaggtgggcg ccttcccctc ttgtgcccag ggcggtgggc gtggtgtcca     1740

cccgcccctc ctggtgccca cggtggatac tgcatgatgt gaaccttggt tttgaactct     1800

gttcctgccc ctccccgacc gccccagcct gtgcccgccc cgtgcctgcc gtggctggtg     1860

ggtggcggtg gtggggccgg gtgggccccc gcccagcgcc tgctggaatg agaagcacag     1920

actccgccac ggactccttt tctctccctc ctcccgcccc gccaggcctg gcggcccccg     1980

cccccctcgc tggccatttt gggggagtga gggggcgtgg ttgtttcttg tggttgtgtg     2040

tgtttgttgt tcgggtttta aaaaagggaa actgagactg caggtggggg aggtggtggg     2100

ttttgggggg atgtccccta atccaggagt gccccctcac ttgtcaccga gtctcctcta     2160

ttgcctgcct ctgctgtgaa ttaacttgtt ctgtgtatta aactgggcct gacccctctg     2220

cccacgaaaa aaaaaaaaaa aaaaaa                                          2246


<210> 108
<211> 380
<212> PRT
<213> Homo sapiens

<400> 108
Met Gly Gly Leu Ser Ala Arg Pro Thr Ala Gly Arg Thr Asp Pro Ala 
1               5                   10                  15      


Gly Thr Cys Trp Gly Gln Asp Pro Gly Ser Lys Met Ala Thr Val Ile 
            20                  25                  30          


Pro Gly Pro Leu Ser Leu Gly Glu Asp Phe Tyr Arg Glu Ala Ile Glu 
        35                  40                  45              


His Cys Arg Ser Tyr Asn Ala Arg Leu Cys Ala Glu Arg Ser Leu Arg 
    50                  55                  60                  


Leu Pro Phe Leu Asp Ser Gln Thr Gly Val Ala Gln Asn Asn Cys Tyr 
65                  70                  75                  80  


Ile Trp Met Glu Lys Thr His Arg Gly Pro Gly Leu Ala Pro Gly Gln 
                85                  90                  95      


Ile Tyr Thr Tyr Pro Ala Arg Cys Trp Arg Lys Lys Arg Arg Leu Asn 
            100                 105                 110         


Ile Leu Glu Asp Pro Arg Leu Arg Pro Cys Glu Tyr Lys Ile Asp Cys 
        115                 120                 125             


Glu Ala Pro Leu Lys Lys Glu Gly Gly Leu Pro Glu Gly Pro Val Leu 
    130                 135                 140                 


Glu Ala Leu Leu Cys Ala Glu Thr Gly Glu Lys Lys Ile Glu Leu Lys 
145                 150                 155                 160 


Glu Glu Glu Thr Ile Met Asp Cys Gln Lys Gln Gln Leu Leu Glu Phe 
                165                 170                 175     


Pro His Asp Leu Glu Val Glu Asp Leu Glu Asp Asp Ile Pro Arg Arg 
            180                 185                 190         


Lys Asn Arg Ala Lys Gly Lys Ala Tyr Gly Ile Gly Gly Leu Arg Lys 
        195                 200                 205             


Arg Gln Asp Thr Ala Ser Leu Glu Asp Arg Asp Lys Pro Tyr Val Cys 
    210                 215                 220                 


Asp Lys Phe Tyr Lys Glu Leu Ala Trp Val Pro Glu Ala Gln Arg Lys 
225                 230                 235                 240 


His Thr Ala Lys Lys Ala Pro Asp Gly Thr Val Ile Pro Asn Gly Tyr 
                245                 250                 255     


Cys Asp Phe Cys Leu Gly Gly Ser Lys Lys Thr Gly Cys Pro Glu Asp 
            260                 265                 270         


Leu Ile Ser Cys Ala Asp Cys Gly Arg Ser Gly His Pro Ser Cys Leu 
        275                 280                 285             


Gln Phe Thr Val Asn Met Thr Ala Ala Val Arg Thr Tyr Arg Trp Gln 
    290                 295                 300                 


Cys Ile Glu Cys Lys Ser Cys Ser Leu Cys Gly Thr Ser Glu Asn Asp 
305                 310                 315                 320 


Gly Ala Ser Trp Ala Gly Leu Thr Pro Gln Asp Gln Leu Leu Phe Cys 
                325                 330                 335     


Asp Asp Cys Asp Arg Gly Tyr His Met Tyr Cys Leu Ser Pro Pro Met 
            340                 345                 350         


Ala Glu Pro Pro Glu Gly Ser Trp Ser Cys His Leu Cys Leu Arg His 
        355                 360                 365             


Leu Lys Glu Lys Ala Ser Ala Tyr Ile Thr Leu Thr 
    370                 375                 380 


<210> 109
<211> 2362
<212> DNA
<213> Homo sapiens

<400> 109
cgcagcccca agaatgaatg aaatcgtagc gcgctgggcg gcagagcggg cggcgcaggc       60

cgggctgggc ccgcgcgcgg cggcagcggc gccccgggcc ggaggcggcc cagccgagcg      120

ggccatggcc accgccattc agaacccgct caagtcgcga ggacttctac cgcgaggcca      180

tcgagcactg ccgcagttac aacgcgcgcc tgtgcgccga gcgcagcctg cgactgccct      240

tcctcgactc gcagaccggc gtggcccaga acaactgcta catctggatg gagaagaccc      300

accgcgggcc gggtttggcc ccgggacaga tttacacgta ccccgcccgc tgttggagga      360

agaaacggag actcaacatc ctggaggacc ccagactcag gccctgcgag tacaagatcg      420

actgtgaagc acccctgaag aaggagggtg gcctcccgga agggccggtc ctcgaggctc      480

tactgtgtgc agagacgggg gagaagaaga ttgagctgaa ggaggaggag accattatgg      540

actgtcagaa acagcagttg ctggagtttc cgcatgacct cgaggtggaa gacttggagg      600

atgacattcc caggaggaag aacagggcca aaggaaaggc atatggcatc gggggtctcc      660

ggaaacgcca ggacaccgct tccctggagg accgagacaa gccgtatgtc tgtgatatct      720

gtgggaaacg gtataagaac cggccggggc tcagctacca ctacacccac acccacctgg      780

ccgaggagga gggggaggag aacgccgaac gccacgccct gcccttccac cggaaaaaca      840

accataaaca gttttacaaa gaattggcct gggtccctga ggcacaaagg aaacacacag      900

ccaagaaggc gcccgacggc actgtcatcc ccaacggcta ctgtgacttc tgcctggggg      960

gctccaagaa gacggggtgt cccgaggacc tcatctcctg tgcggactgt gggcgatcag     1020

gacacccctc gtgtttacaa ttcacggtga acatgacggc agccgtgcgg acctaccgct     1080

ggcagtgcat cgagtgcaaa tcctgcagcc tgtgcggaac ctccgagaac gacgaccagc     1140

tgctgttttg tgatgactgc gatcggggtt accacatgta ctgcctgagt ccccccatgg     1200

cggagccccc ggaagggagc tggagctgtc acctctgtct ccggcacctg aaggaaaagg     1260

cttctgctta catcaccctc acctaggccg gctcggctcg ccgcgactct ggggtggtgc     1320

tcgcctacct gcctctccga gctcctcaat tctcccccac cctgaacatc ccgcaggggg     1380

agggggagag ggggaagccg agagggggct gggccacccc ctcccctctg tgcaagtgga     1440

atgtctgccc tgtgggtggg tgggcccggc cagggcctct ccctccctcc ctccctctct     1500

gtcccttggc aaatggacac caggggcttc tcccctcaaa gccatacccc gcctctgggc     1560

gggcatgggg ggtggtgggt gccagccagg ggcatggaca gagccttttt ctaaagaaaa     1620

agacaaaaag ttaaaaaaaa aaaaaagaag aaaagaaaag aagttaatat atacaaagag     1680

tcctccaagg cctggctggg tggaggggcg ctgctgagag tgtccaccgg gcacccgcct     1740

ctgccggccc cccgccgggc gccccaaccc caatttctgg agctgcagcc gtcccgcgcc     1800

ccacccaagg tgggcgcctt cccctcttgt gcccagggcg gtgggcgtgg tgtccacccg     1860

cccctcctgg tgcccacggt ggatactgca tgatgtgaac cttggttttg aactctgttc     1920

ctgcccctcc ccgaccgccc cagcctgtgc ccgccccgtg cctgccgtgg ctggtgggtg     1980

gcggtggtgg ggccgggtgg gcccccgccc agcgcctgct ggaatgagaa gcacagactc     2040

cgccacggac tccttttctc tccctcctcc cgccccgcca ggcctggcgg cccccgcccc     2100

cctcgctggc cattttgggg gagtgagggg gcgtggttgt ttcttgtggt tgtgtgtgtt     2160

tgttgttcgg gttttaaaaa agggaaactg agactgcagg tgggggaggt ggtgggtttt     2220

ggggggatgt cccctaatcc aggagtgccc cctcacttgt caccgagtct cctctattgc     2280

ctgcctctgc tgtgaattaa cttgttctgt gtattaaact gggcctgacc cctctgccca     2340

cgaaaaaaaa aaaaaaaaaa aa                                              2362


<210> 110
<211> 332
<212> PRT
<213> Homo sapiens

<400> 110
Met Glu Lys Thr His Arg Gly Pro Gly Leu Ala Pro Gly Gln Ile Tyr 
1               5                   10                  15      


Thr Tyr Pro Ala Arg Cys Trp Arg Lys Lys Arg Arg Leu Asn Ile Leu 
            20                  25                  30          


Glu Asp Pro Arg Leu Arg Pro Cys Glu Tyr Lys Ile Asp Cys Glu Ala 
        35                  40                  45              


Pro Leu Lys Lys Glu Gly Gly Leu Pro Glu Gly Pro Val Leu Glu Ala 
    50                  55                  60                  


Leu Leu Cys Ala Glu Thr Gly Glu Lys Lys Ile Glu Leu Lys Glu Glu 
65                  70                  75                  80  


Glu Thr Ile Met Asp Cys Gln Lys Gln Gln Leu Leu Glu Phe Pro His 
                85                  90                  95      


Asp Leu Glu Val Glu Asp Leu Glu Asp Asp Ile Pro Arg Arg Lys Asn 
            100                 105                 110         


Arg Ala Lys Gly Lys Ala Tyr Gly Ile Gly Gly Leu Arg Lys Arg Gln 
        115                 120                 125             


Asp Thr Ala Ser Leu Glu Asp Arg Asp Lys Pro Tyr Val Cys Asp Ile 
    130                 135                 140                 


Cys Gly Lys Arg Tyr Lys Asn Arg Pro Gly Leu Ser Tyr His Tyr Thr 
145                 150                 155                 160 


His Thr His Leu Ala Glu Glu Glu Gly Glu Glu Asn Ala Glu Arg His 
                165                 170                 175     


Ala Leu Pro Phe His Arg Lys Asn Asn His Lys Gln Phe Tyr Lys Glu 
            180                 185                 190         


Leu Ala Trp Val Pro Glu Ala Gln Arg Lys His Thr Ala Lys Lys Ala 
        195                 200                 205             


Pro Asp Gly Thr Val Ile Pro Asn Gly Tyr Cys Asp Phe Cys Leu Gly 
    210                 215                 220                 


Gly Ser Lys Lys Thr Gly Cys Pro Glu Asp Leu Ile Ser Cys Ala Asp 
225                 230                 235                 240 


Cys Gly Arg Ser Gly His Pro Ser Cys Leu Gln Phe Thr Val Asn Met 
                245                 250                 255     


Thr Ala Ala Val Arg Thr Tyr Arg Trp Gln Cys Ile Glu Cys Lys Ser 
            260                 265                 270         


Cys Ser Leu Cys Gly Thr Ser Glu Asn Asp Asp Gln Leu Leu Phe Cys 
        275                 280                 285             


Asp Asp Cys Asp Arg Gly Tyr His Met Tyr Cys Leu Ser Pro Pro Met 
    290                 295                 300                 


Ala Glu Pro Pro Glu Gly Ser Trp Ser Cys His Leu Cys Leu Arg His 
305                 310                 315                 320 


Leu Lys Glu Lys Ala Ser Ala Tyr Ile Thr Leu Thr 
                325                 330         


<210> 111
<211> 2378
<212> DNA
<213> Homo sapiens

<400> 111
gtgctcccgc cccccgggaa tgaatggatg ggcggcctca gcgcccgccc gaccgctggg       60

aggaccgacc cggcggggac ctgctggggg caggacccgg ggagcaagat ggccactgtc      120

atccctggcc ccctgagcct aggcgaggac ttctaccgcg aggccatcga gcactgccgc      180

agttacaacg cgcgcctgtg cgccgagcgc agcctgcgac tgcccttcct cgactcgcag      240

accggcgtgg cccagaacaa ctgctacatc tggatggaga agacccaccg cgggccgggt      300

ttggccccgg gacagattta cacgtacccc gcccgctgtt ggaggaagaa acggagactc      360

aacatcctgg aggaccccag actcaggccc tgcgagtaca agatcgactg tgaagcaccc      420

ctgaagaagg agggtggcct cccggaaggg ccggtcctcg aggctctact gtgtgcagag      480

acgggggaga agaagattga gctgaaggag gaggagacca ttatggactg tcagaaacag      540

cagttgctgg agtttccgca tgacctcgag gtggaagact tggaggatga cattcccagg      600

aggaagaaca gggccaaagg aaaggcatat ggcatcgggg gtctccggaa acgccaggac      660

accgcttccc tggaggaccg agacaagccg tatgtctgtg atatctgtgg gaaacggtat      720

aagaaccggc cggggctcag ctaccactac acccacaccc acctggccga ggaggagggg      780

gaggagaacg ccgaacgcca cgccctgccc ttccaccgga aaaacaacca taaacagttt      840

tacaaagaat tggcctgggt ccctgaggca caaaggaaac acacagccaa gaaggcgccc      900

gacggcactg tcatccccaa cggctactgt gacttctgcc tggggggctc caagaagacg      960

gggtgtcccg aggacctcat ctcctgtgcg gactgtgggc gatcaggaca cccctcgtgt     1020

ttacaattca cggtgaacat gacggcagcc gtgcggacct accgctggca gtgcatcgag     1080

tgcaaatcct gcagcctgtg cggaacctcc gagaacgacg gtgccagctg ggcgggtctc     1140

accccccagg accagctgct gttttgtgat gactgcgatc ggggttacca catgtactgc     1200

ctgagtcccc ccatggcgga gcccccggaa gggagctgga gctgtcacct ctgtctccgg     1260

cacctgaagg aaaaggcttc tgcttacatc accctcacct aggccggctc ggctcgccgc     1320

gactctgggg tggtgctcgc ctacctgcct ctccgagctc ctcaattctc ccccaccctg     1380

aacatcccgc agggggaggg ggagaggggg aagccgagag ggggctgggc caccccctcc     1440

cctctgtgca agtggaatgt ctgccctgtg ggtgggtggg cccggccagg gcctctccct     1500

ccctccctcc ctctctgtcc cttggcaaat ggacaccagg ggcttctccc ctcaaagcca     1560

taccccgcct ctgggcgggc atggggggtg gtgggtgcca gccaggggca tggacagagc     1620

ctttttctaa agaaaaagac aaaaagttaa aaaaaaaaaa aagaagaaaa gaaaagaagt     1680

taatatatac aaagagtcct ccaaggcctg gctgggtgga ggggcgctgc tgagagtgtc     1740

caccgggcac ccgcctctgc cggccccccg ccgggcgccc caaccccaat ttctggagct     1800

gcagccgtcc cgcgccccac ccaaggtggg cgccttcccc tcttgtgccc agggcggtgg     1860

gcgtggtgtc cacccgcccc tcctggtgcc cacggtggat actgcatgat gtgaaccttg     1920

gttttgaact ctgttcctgc ccctccccga ccgccccagc ctgtgcccgc cccgtgcctg     1980

ccgtggctgg tgggtggcgg tggtggggcc gggtgggccc ccgcccagcg cctgctggaa     2040

tgagaagcac agactccgcc acggactcct tttctctccc tcctcccgcc ccgccaggcc     2100

tggcggcccc cgcccccctc gctggccatt ttgggggagt gagggggcgt ggttgtttct     2160

tgtggttgtg tgtgtttgtt gttcgggttt taaaaaaggg aaactgagac tgcaggtggg     2220

ggaggtggtg ggttttgggg ggatgtcccc taatccagga gtgccccctc acttgtcacc     2280

gagtctcctc tattgcctgc ctctgctgtg aattaacttg ttctgtgtat taaactgggc     2340

ctgacccctc tgcccacgaa aaaaaaaaaa aaaaaaaa                             2378


<210> 112
<211> 424
<212> PRT
<213> Homo sapiens

<400> 112
Met Gly Gly Leu Ser Ala Arg Pro Thr Ala Gly Arg Thr Asp Pro Ala 
1               5                   10                  15      


Gly Thr Cys Trp Gly Gln Asp Pro Gly Ser Lys Met Ala Thr Val Ile 
            20                  25                  30          


Pro Gly Pro Leu Ser Leu Gly Glu Asp Phe Tyr Arg Glu Ala Ile Glu 
        35                  40                  45              


His Cys Arg Ser Tyr Asn Ala Arg Leu Cys Ala Glu Arg Ser Leu Arg 
    50                  55                  60                  


Leu Pro Phe Leu Asp Ser Gln Thr Gly Val Ala Gln Asn Asn Cys Tyr 
65                  70                  75                  80  


Ile Trp Met Glu Lys Thr His Arg Gly Pro Gly Leu Ala Pro Gly Gln 
                85                  90                  95      


Ile Tyr Thr Tyr Pro Ala Arg Cys Trp Arg Lys Lys Arg Arg Leu Asn 
            100                 105                 110         


Ile Leu Glu Asp Pro Arg Leu Arg Pro Cys Glu Tyr Lys Ile Asp Cys 
        115                 120                 125             


Glu Ala Pro Leu Lys Lys Glu Gly Gly Leu Pro Glu Gly Pro Val Leu 
    130                 135                 140                 


Glu Ala Leu Leu Cys Ala Glu Thr Gly Glu Lys Lys Ile Glu Leu Lys 
145                 150                 155                 160 


Glu Glu Glu Thr Ile Met Asp Cys Gln Lys Gln Gln Leu Leu Glu Phe 
                165                 170                 175     


Pro His Asp Leu Glu Val Glu Asp Leu Glu Asp Asp Ile Pro Arg Arg 
            180                 185                 190         


Lys Asn Arg Ala Lys Gly Lys Ala Tyr Gly Ile Gly Gly Leu Arg Lys 
        195                 200                 205             


Arg Gln Asp Thr Ala Ser Leu Glu Asp Arg Asp Lys Pro Tyr Val Cys 
    210                 215                 220                 


Asp Ile Cys Gly Lys Arg Tyr Lys Asn Arg Pro Gly Leu Ser Tyr His 
225                 230                 235                 240 


Tyr Thr His Thr His Leu Ala Glu Glu Glu Gly Glu Glu Asn Ala Glu 
                245                 250                 255     


Arg His Ala Leu Pro Phe His Arg Lys Asn Asn His Lys Gln Phe Tyr 
            260                 265                 270         


Lys Glu Leu Ala Trp Val Pro Glu Ala Gln Arg Lys His Thr Ala Lys 
        275                 280                 285             


Lys Ala Pro Asp Gly Thr Val Ile Pro Asn Gly Tyr Cys Asp Phe Cys 
    290                 295                 300                 


Leu Gly Gly Ser Lys Lys Thr Gly Cys Pro Glu Asp Leu Ile Ser Cys 
305                 310                 315                 320 


Ala Asp Cys Gly Arg Ser Gly His Pro Ser Cys Leu Gln Phe Thr Val 
                325                 330                 335     


Asn Met Thr Ala Ala Val Arg Thr Tyr Arg Trp Gln Cys Ile Glu Cys 
            340                 345                 350         


Lys Ser Cys Ser Leu Cys Gly Thr Ser Glu Asn Asp Gly Ala Ser Trp 
        355                 360                 365             


Ala Gly Leu Thr Pro Gln Asp Gln Leu Leu Phe Cys Asp Asp Cys Asp 
    370                 375                 380                 


Arg Gly Tyr His Met Tyr Cys Leu Ser Pro Pro Met Ala Glu Pro Pro 
385                 390                 395                 400 


Glu Gly Ser Trp Ser Cys His Leu Cys Leu Arg His Leu Lys Glu Lys 
                405                 410                 415     


Ala Ser Ala Tyr Ile Thr Leu Thr 
            420                 


<210> 113
<211> 2329
<212> DNA
<213> Homo sapiens

<400> 113
gaaatcgtag cgcgctgggc ggcagagcgg gcggcgcagg ccgggctggg cccgcgcgcg       60

gcggcagcgg cgccccgggc cggaggcggc ccagccgagc gggccatggc caccgccatt      120

cagaacccgc tcaagtccct aggcgaggac ttctaccgcg aggccatcga gcactgccgc      180

agttacaacg cgcgcctgtg cgccgagcgc agcctgcgac tgcccttcct cgactcgcag      240

accggcgtgg cccagaacaa ctgctacatc tggatggaga agacccaccg cgggccgggt      300

ttggccccgg gacagattta cacgtacccc gcccgctgtt ggaggaagaa acggagactc      360

aacatcctgg aggaccccag actcaggccc tgcgagtaca agatcgactg tgaagcaccc      420

ctgaagaagg agggtggcct cccggaaggg ccggtcctcg aggctctact gtgtgcagag      480

acgggggaga agaagattga gctgaaggag gaggagacca ttatggactg tcagaaacag      540

cagttgctgg agtttccgca tgacctcgag gtggaagact tggaggatga cattcccagg      600

aggaagaaca gggccaaagg aaaggcatat ggcatcgggg gtctccggaa acgccaggac      660

accgcttccc tggaggaccg agacaagccg tatgtctgtg atatctgtgg gaaacggtat      720

aagaaccggc cggggctcag ctaccactac acccacaccc acctggccga ggaggagggg      780

gaggagaacg ccgaacgcca cgccctgccc ttccaccgga aaaacaacca taaacagttt      840

tacaaagaat tggcctgggt ccctgaggca caaaggaaac acacagccaa gaaggcgccc      900

gacggcactg tcatccccaa cggctactgt gacttctgcc tggggggctc caagaagacg      960

gggtgtcccg aggacctcat ctcctgtgcg gactgtgggc gatcaggaca cccctcgtgt     1020

ttacaattca cggtgaacat gacggcagcc gtgcggacct accgctggca gtgcatcgag     1080

tgcaaatcct gcagcctgtg cggaacctcc gagaacgacg accagctgct gttttgtgat     1140

gactgcgatc ggggttacca catgtactgc ctgagtcccc ccatggcgga gcccccggaa     1200

gggagctgga gctgtcacct ctgtctccgg cacctgaagg aaaaggcttc tgcttacatc     1260

accctcacct aggccggctc ggctcgccgc gactctgggg tggtgctcgc ctacctgcct     1320

ctccgagctc ctcaattctc ccccaccctg aacatcccgc agggggaggg ggagaggggg     1380

aagccgagag ggggctgggc caccccctcc cctctgtgca agtggaatgt ctgccctgtg     1440

ggtgggtggg cccggccagg gcctctccct ccctccctcc ctctctgtcc cttggcaaat     1500

ggacaccagg ggcttctccc ctcaaagcca taccccgcct ctgggcgggc atggggggtg     1560

gtgggtgcca gccaggggca tggacagagc ctttttctaa agaaaaagac aaaaagttaa     1620

aaaaaaaaaa aagaagaaaa gaaaagaagt taatatatac aaagagtcct ccaaggcctg     1680

gctgggtgga ggggcgctgc tgagagtgtc caccgggcac ccgcctctgc cggccccccg     1740

ccgggcgccc caaccccaat ttctggagct gcagccgtcc cgcgccccac ccaaggtggg     1800

cgccttcccc tcttgtgccc agggcggtgg gcgtggtgtc cacccgcccc tcctggtgcc     1860

cacggtggat actgcatgat gtgaaccttg gttttgaact ctgttcctgc ccctccccga     1920

ccgccccagc ctgtgcccgc cccgtgcctg ccgtggctgg tgggtggcgg tggtggggcc     1980

gggtgggccc ccgcccagcg cctgctggaa tgagaagcac agactccgcc acggactcct     2040

tttctctccc tcctcccgcc ccgccaggcc tggcggcccc cgcccccctc gctggccatt     2100

ttgggggagt gagggggcgt ggttgtttct tgtggttgtg tgtgtttgtt gttcgggttt     2160

taaaaaaggg aaactgagac tgcaggtggg ggaggtggtg ggttttgggg ggatgtcccc     2220

taatccagga gtgccccctc acttgtcacc gagtctcctc tattgcctgc ctctgctgtg     2280

aattaacttg ttctgtgtat taaactgggc ctgacccctc tgcccacga                 2329


<210> 114
<211> 388
<212> PRT
<213> Homo sapiens

<400> 114
Met Ala Thr Ala Ile Gln Asn Pro Leu Lys Ser Leu Gly Glu Asp Phe 
1               5                   10                  15      


Tyr Arg Glu Ala Ile Glu His Cys Arg Ser Tyr Asn Ala Arg Leu Cys 
            20                  25                  30          


Ala Glu Arg Ser Leu Arg Leu Pro Phe Leu Asp Ser Gln Thr Gly Val 
        35                  40                  45              


Ala Gln Asn Asn Cys Tyr Ile Trp Met Glu Lys Thr His Arg Gly Pro 
    50                  55                  60                  


Gly Leu Ala Pro Gly Gln Ile Tyr Thr Tyr Pro Ala Arg Cys Trp Arg 
65                  70                  75                  80  


Lys Lys Arg Arg Leu Asn Ile Leu Glu Asp Pro Arg Leu Arg Pro Cys 
                85                  90                  95      


Glu Tyr Lys Ile Asp Cys Glu Ala Pro Leu Lys Lys Glu Gly Gly Leu 
            100                 105                 110         


Pro Glu Gly Pro Val Leu Glu Ala Leu Leu Cys Ala Glu Thr Gly Glu 
        115                 120                 125             


Lys Lys Ile Glu Leu Lys Glu Glu Glu Thr Ile Met Asp Cys Gln Lys 
    130                 135                 140                 


Gln Gln Leu Leu Glu Phe Pro His Asp Leu Glu Val Glu Asp Leu Glu 
145                 150                 155                 160 


Asp Asp Ile Pro Arg Arg Lys Asn Arg Ala Lys Gly Lys Ala Tyr Gly 
                165                 170                 175     


Ile Gly Gly Leu Arg Lys Arg Gln Asp Thr Ala Ser Leu Glu Asp Arg 
            180                 185                 190         


Asp Lys Pro Tyr Val Cys Asp Ile Cys Gly Lys Arg Tyr Lys Asn Arg 
        195                 200                 205             


Pro Gly Leu Ser Tyr His Tyr Thr His Thr His Leu Ala Glu Glu Glu 
    210                 215                 220                 


Gly Glu Glu Asn Ala Glu Arg His Ala Leu Pro Phe His Arg Lys Asn 
225                 230                 235                 240 


Asn His Lys Gln Phe Tyr Lys Glu Leu Ala Trp Val Pro Glu Ala Gln 
                245                 250                 255     


Arg Lys His Thr Ala Lys Lys Ala Pro Asp Gly Thr Val Ile Pro Asn 
            260                 265                 270         


Gly Tyr Cys Asp Phe Cys Leu Gly Gly Ser Lys Lys Thr Gly Cys Pro 
        275                 280                 285             


Glu Asp Leu Ile Ser Cys Ala Asp Cys Gly Arg Ser Gly His Pro Ser 
    290                 295                 300                 


Cys Leu Gln Phe Thr Val Asn Met Thr Ala Ala Val Arg Thr Tyr Arg 
305                 310                 315                 320 


Trp Gln Cys Ile Glu Cys Lys Ser Cys Ser Leu Cys Gly Thr Ser Glu 
                325                 330                 335     


Asn Asp Asp Gln Leu Leu Phe Cys Asp Asp Cys Asp Arg Gly Tyr His 
            340                 345                 350         


Met Tyr Cys Leu Ser Pro Pro Met Ala Glu Pro Pro Glu Gly Ser Trp 
        355                 360                 365             


Ser Cys His Leu Cys Leu Arg His Leu Lys Glu Lys Ala Ser Ala Tyr 
    370                 375                 380                 


Ile Thr Leu Thr 
385             


<210> 115
<211> 2278
<212> DNA
<213> Mus musculus

<400> 115
gcaggccggg ctgggcccgc gctcagcggc agcagcagcg gcgccccggg ccggaggcgg       60

cccagccgag cgggccatgg ccaccgccat tcagaacccg ctcaagtccc ttggcgagga      120

cttctaccgg gaggccatcg agcactgtcg cagctacaac gcgcgcctgt gtgccgagcg      180

cagcctgcgc ctgcctttcc tcgactcgca gaccggagtg gcccagaaca actgctacat      240

ctggatggag aagacccacc gcgggcctgg tttggccccg ggacagatct acacttaccc      300

cgcccgctgt tggaggaaga aacggagact caacatcctg gaggacccca ggctccggcc      360

ctgcgagtac aagatcgatt gtgaggcacc tctgaagaag gagggtggcc tcccggaagg      420

gccagtcctc gaggctctgc tgtgtgctga gactggagag aagaaagtgg agctgaagga      480

ggaggagacc atcatggact gtcagaaaca gcagttgctg gagtttccgc atgatctcga      540

ggtagaagac ttggaggaag acattcccag gaggaagaac agggcaagag gaaaggcata      600

tggcattgga ggtctccgca aacgccagga caccgcatcc ctggaggacc gagacaagcc      660

gtacgtctgt gatatctgtg ggaagagata taagaaccgg ccaggactca gctaccatta      720

cacccacacc cacctggctg aggaggaggg ggaggagcac actgaacgcc acgccctgcc      780

tttccaccgg aaaaacaacc ataaacagtt ttacaaagaa ttggcctggg tccccgaggc      840

acagaggaaa cacacagcca agaaagcacc agatggcact gtcatcccca atggctactg      900

tgacttttgc ctggggggct ccaagaagac tgggtgtccc gaggacctca tctcctgtgc      960

ggactgtggg cgatcaggac atccctcgtg tttacagttc acggtgaaca tgaccgcggc     1020

tgtgcggacc taccgctggc agtgcattga atgcaagtcc tgcagcctgt gtggcacctc     1080

ggagaatgac gaccagctgc tgttctgtga tgactgcgat cgaggttacc acatgtactg     1140

cctgagccct cccatggcgg agcccccgga agggagctgg agctgccacc tctgtctccg     1200

gcacttgaag gaaaaggcct ctgcttacat caccctgacc taggcccggc tctgcttccc     1260

caggatcttt gggtggtgct atctcctgcc tcttggagct cctggcgctc cccacccggt     1320

gtccccagtg gaagggatgg ggtgaagccc agagtggggg ggggcaaggt gttctccctc     1380

tgcaagtgga atgttaccct gtgggtggct gggtccaaca gggtccctcc tgtcccccct     1440

cttcatccct tgacaaatgg gcaccaggct tctgctctcc tcaaagccat acccccgcct     1500

ttgggcgggc atagaggggt agtggatgct agccagcagc acggaaagag cctttttcta     1560

aagaaaaaga caaaacgtgg aaaaaaaagg gaaaaaaatt aatatataca aagagtccta     1620

taaagcctgg ctgggtggag aggcactgtt gagtgtctgc tggggacctg actttaccag     1680

tttcctgaat ggcgcctccc cacctcattt ctggagttgc aatggtctca actcccatct     1740

gaggtgggta ccaccccttc ctcagtaccc accgtggata ctgcatgtga actatggttt     1800

tgaactcttc ctcctcctcc ttgagagccc cgccctgcgc ccgcgtggtg cctgcctgcc     1860

aggcctgggg cgtgcagccg gggaggcggg tggggtgagg caggcaggca gccagccccc     1920

tgcagtgaga agcacagatt gcaatggact cagttttttt tttttttttt tttttttttc     1980

ctttctccct tcccacccct ttccttccct acccagccag gctgggctgc ctcctgcccc     2040

cctcgctagc catttggggg tggcaagggg gtgtggttgt ttctcgtggt tgtgtgtgtt     2100

tgttgttcgg gtttttaaaa ggggaaattg agactgcaag tgggggaggt ggagggtctg     2160

ggggagtctg cccccaatcc aggagtaccc cccttgccac caagtctcct ttattgcctg     2220

cctctgctgt gaattaactt gttctgtgta ttaaactggg cctgacccct ctgcccac       2278


<210> 116
<211> 388
<212> PRT
<213> Mus musculus

<400> 116
Met Ala Thr Ala Ile Gln Asn Pro Leu Lys Ser Leu Gly Glu Asp Phe 
1               5                   10                  15      


Tyr Arg Glu Ala Ile Glu His Cys Arg Ser Tyr Asn Ala Arg Leu Cys 
            20                  25                  30          


Ala Glu Arg Ser Leu Arg Leu Pro Phe Leu Asp Ser Gln Thr Gly Val 
        35                  40                  45              


Ala Gln Asn Asn Cys Tyr Ile Trp Met Glu Lys Thr His Arg Gly Pro 
    50                  55                  60                  


Gly Leu Ala Pro Gly Gln Ile Tyr Thr Tyr Pro Ala Arg Cys Trp Arg 
65                  70                  75                  80  


Lys Lys Arg Arg Leu Asn Ile Leu Glu Asp Pro Arg Leu Arg Pro Cys 
                85                  90                  95      


Glu Tyr Lys Ile Asp Cys Glu Ala Pro Leu Lys Lys Glu Gly Gly Leu 
            100                 105                 110         


Pro Glu Gly Pro Val Leu Glu Ala Leu Leu Cys Ala Glu Thr Gly Glu 
        115                 120                 125             


Lys Lys Val Glu Leu Lys Glu Glu Glu Thr Ile Met Asp Cys Gln Lys 
    130                 135                 140                 


Gln Gln Leu Leu Glu Phe Pro His Asp Leu Glu Val Glu Asp Leu Glu 
145                 150                 155                 160 


Glu Asp Ile Pro Arg Arg Lys Asn Arg Ala Arg Gly Lys Ala Tyr Gly 
                165                 170                 175     


Ile Gly Gly Leu Arg Lys Arg Gln Asp Thr Ala Ser Leu Glu Asp Arg 
            180                 185                 190         


Asp Lys Pro Tyr Val Cys Asp Ile Cys Gly Lys Arg Tyr Lys Asn Arg 
        195                 200                 205             


Pro Gly Leu Ser Tyr His Tyr Thr His Thr His Leu Ala Glu Glu Glu 
    210                 215                 220                 


Gly Glu Glu His Thr Glu Arg His Ala Leu Pro Phe His Arg Lys Asn 
225                 230                 235                 240 


Asn His Lys Gln Phe Tyr Lys Glu Leu Ala Trp Val Pro Glu Ala Gln 
                245                 250                 255     


Arg Lys His Thr Ala Lys Lys Ala Pro Asp Gly Thr Val Ile Pro Asn 
            260                 265                 270         


Gly Tyr Cys Asp Phe Cys Leu Gly Gly Ser Lys Lys Thr Gly Cys Pro 
        275                 280                 285             


Glu Asp Leu Ile Ser Cys Ala Asp Cys Gly Arg Ser Gly His Pro Ser 
    290                 295                 300                 


Cys Leu Gln Phe Thr Val Asn Met Thr Ala Ala Val Arg Thr Tyr Arg 
305                 310                 315                 320 


Trp Gln Cys Ile Glu Cys Lys Ser Cys Ser Leu Cys Gly Thr Ser Glu 
                325                 330                 335     


Asn Asp Asp Gln Leu Leu Phe Cys Asp Asp Cys Asp Arg Gly Tyr His 
            340                 345                 350         


Met Tyr Cys Leu Ser Pro Pro Met Ala Glu Pro Pro Glu Gly Ser Trp 
        355                 360                 365             


Ser Cys His Leu Cys Leu Arg His Leu Lys Glu Lys Ala Ser Ala Tyr 
    370                 375                 380                 


Ile Thr Leu Thr 
385             


<210> 117
<211> 2545
<212> DNA
<213> Homo sapiens

<400> 117
agtgctcgct ctagtgcgcg cgcccggacg gcgcctgcgc agagggcaag gaacctggta       60

ccccggtgcg gtcccggcgc ctgcgcgctg cggactgtgg ggcttctcgg cccgaggcag      120

aggaacaggg aagatggcgg ctgtggtgga gaatgtagtg aagctccttg gggagcagta      180

ctacaaagat gccatggagc agtgccacaa ttacaatgct cgcctctgtg ctgagcgcag      240

cgtgcgcctg cctttcttgg actcacagac cggagtagcc cagagcaatt gttacatctg      300

gatggaaaag cgacaccggg gtccaggatt ggcctccgga cagctgtact cctaccctgc      360

ccggcgctgg cggaaaaagc ggcgagccca tccccctgag gatccacgac tttccttccc      420

atctattaag ccagacacag accagaccct gaagaaggag gggctgatct ctcaggatgg      480

cagtagttta gaggctctgt tgcgcactga ccccctggag aagcgaggtg ccccggatcc      540

ccgagttgat gatgacagcc tgggcgagtt tcctgtgacc aacagtcgag cgcgaaagcg      600

gatcctagaa ccagatgact tcctggatga cctcgatgat gaagactatg aagaagatac      660

tcccaagcgt cggggaaagg ggaaatccaa gggtaagggt gtgggcagtg cccgtaagaa      720

gctggatgct tccatcctgg aggaccggga taagccctat gcctgtgaca tttgtggaaa      780

acgttacaag aaccgaccag gcctcagtta ccactatgcc cactcccact tggctgagga      840

ggagggcgag gacaaggaag actctcaacc acccactcct gtttcccaga ggtctgagga      900

gcagaaatcc aaaaagggtc ctgatggatt ggccttgccc aacaactact gtgacttctg      960

cctgggggac tcaaagatta acaagaagac gggacaaccc gaggagctgg tgtcctgttc     1020

tgactgtggc cgctcagggc atccatcttg cctccaattt acccccgtga tgatggcggc     1080

agtgaagaca taccgctggc agtgcatcga gtgcaaatgt tgcaatatct gcggcacctc     1140

cgagaatgac gaccagttgc tcttctgtga tgactgcgat cgtggctacc acatgtactg     1200

tctcaccccg tccatgtctg agccccctga aggaagttgg agctgccacc tgtgtctgga     1260

cctgttgaaa gagaaagctt ccatctacca gaaccagaac tcctcttgat gtggccaccc     1320

acctgctccc cgacatatct aaggctgttt ctctcctcca cttcatattt catacccatc     1380

tttcccttct tcctcctctc cttcacaaat ccagagaacc ttggggtggt tgtgccagcc     1440

tgcctttggc agctgcaagc tgaggtggca gctctgacca cctctggccc caggccctca     1500

gggagaaagg agcaacacac tgcccctagg cgtgcgtgtg gcccagtttc tctctgctct     1560

ccattaagtg cattcactct gcttgccttg ggcccagccc ctggtgatca cagggttcaa     1620

acagtgtcct cctagaaaga gtgggagagc agctcacttc tctgtgttct gcctcccctc     1680

tggtctccag agttttcctg tcctctagag gcaagccagg ccagggagct gggagcgagc     1740

aagctgaggc cacgtccaca aggagctttt catgcccctg tgccgcatag cctcacctct     1800

ttcctccaga gtggctctct gcggccctgt gttcctgcta cagagtgttc ttttctggag     1860

tcaggatgtt ctcggtcacc ctcctggttc tgccctgtcc cattccaccc caccccaggg     1920

ggaacagtag cttcaccttg ttattcccat tgctctcctg gctcactctt acggtcggtc     1980

tccagtgact gaagcattcc ccacccttgg aatttctcat cttctgcctc ccttcctact     2040

ccttttggtt ttgtggggag aggggaagga tcagggggcc aggccagcag ctcgggggcc     2100

acaaggagat ggataatgtg cctgtttttt aacacaacaa aaaagcctac ctccaaaatc     2160

ccctttttgt tcttcctgga cctgggcatt cagcctcctg ctcttaactg aattgggagc     2220

ctctgccacc tgccccgtgt atcctggctc tcagctcatg gggaagccac atagacatcc     2280

ctttcttccc ttgcacgctc gctagcagct ggtaaggtct tcacaccctg attcctcaag     2340

ttttctgctt agtggcactg acattaagta gtggggggac agtccatgcc aggacaccct     2400

ggagtagcct tcccccttgg ccgtgggcag gccctaactc actgtcgctt tggagttgag     2460

gtgtcttttt tttttctttc tttagttcct gtattctaaa cattagtaaa aataaatgtt     2520

tttacacaga aaaaaaaaaa aaaaa                                           2545


<210> 118
<211> 391
<212> PRT
<213> Homo sapiens

<400> 118
Met Ala Ala Val Val Glu Asn Val Val Lys Leu Leu Gly Glu Gln Tyr 
1               5                   10                  15      


Tyr Lys Asp Ala Met Glu Gln Cys His Asn Tyr Asn Ala Arg Leu Cys 
            20                  25                  30          


Ala Glu Arg Ser Val Arg Leu Pro Phe Leu Asp Ser Gln Thr Gly Val 
        35                  40                  45              


Ala Gln Ser Asn Cys Tyr Ile Trp Met Glu Lys Arg His Arg Gly Pro 
    50                  55                  60                  


Gly Leu Ala Ser Gly Gln Leu Tyr Ser Tyr Pro Ala Arg Arg Trp Arg 
65                  70                  75                  80  


Lys Lys Arg Arg Ala His Pro Pro Glu Asp Pro Arg Leu Ser Phe Pro 
                85                  90                  95      


Ser Ile Lys Pro Asp Thr Asp Gln Thr Leu Lys Lys Glu Gly Leu Ile 
            100                 105                 110         


Ser Gln Asp Gly Ser Ser Leu Glu Ala Leu Leu Arg Thr Asp Pro Leu 
        115                 120                 125             


Glu Lys Arg Gly Ala Pro Asp Pro Arg Val Asp Asp Asp Ser Leu Gly 
    130                 135                 140                 


Glu Phe Pro Val Thr Asn Ser Arg Ala Arg Lys Arg Ile Leu Glu Pro 
145                 150                 155                 160 


Asp Asp Phe Leu Asp Asp Leu Asp Asp Glu Asp Tyr Glu Glu Asp Thr 
                165                 170                 175     


Pro Lys Arg Arg Gly Lys Gly Lys Ser Lys Gly Lys Gly Val Gly Ser 
            180                 185                 190         


Ala Arg Lys Lys Leu Asp Ala Ser Ile Leu Glu Asp Arg Asp Lys Pro 
        195                 200                 205             


Tyr Ala Cys Asp Ile Cys Gly Lys Arg Tyr Lys Asn Arg Pro Gly Leu 
    210                 215                 220                 


Ser Tyr His Tyr Ala His Ser His Leu Ala Glu Glu Glu Gly Glu Asp 
225                 230                 235                 240 


Lys Glu Asp Ser Gln Pro Pro Thr Pro Val Ser Gln Arg Ser Glu Glu 
                245                 250                 255     


Gln Lys Ser Lys Lys Gly Pro Asp Gly Leu Ala Leu Pro Asn Asn Tyr 
            260                 265                 270         


Cys Asp Phe Cys Leu Gly Asp Ser Lys Ile Asn Lys Lys Thr Gly Gln 
        275                 280                 285             


Pro Glu Glu Leu Val Ser Cys Ser Asp Cys Gly Arg Ser Gly His Pro 
    290                 295                 300                 


Ser Cys Leu Gln Phe Thr Pro Val Met Met Ala Ala Val Lys Thr Tyr 
305                 310                 315                 320 


Arg Trp Gln Cys Ile Glu Cys Lys Cys Cys Asn Ile Cys Gly Thr Ser 
                325                 330                 335     


Glu Asn Asp Asp Gln Leu Leu Phe Cys Asp Asp Cys Asp Arg Gly Tyr 
            340                 345                 350         


His Met Tyr Cys Leu Thr Pro Ser Met Ser Glu Pro Pro Glu Gly Ser 
        355                 360                 365             


Trp Ser Cys His Leu Cys Leu Asp Leu Leu Lys Glu Lys Ala Ser Ile 
    370                 375                 380                 


Tyr Gln Asn Gln Asn Ser Ser 
385                 390     


<210> 119
<211> 3897
<212> DNA
<213> Homo sapiens

<400> 119
agtgctcgct ctagtgcgcg cgcccggacg gcgcctgcgc agagggcaag gaacctggta       60

ccccggtgcg gtcccggcgc ctgcgcgctg cggactgtgg ggcttctcgg cccgaggcag      120

aggaacaggg aagatggcgg ctgtggtgga gaatgtagtg aagctccttg gggagcagta      180

ctacaaagat gccatggagc agtgccacaa ttacaatgct cgcctctgtg ctgagcgcag      240

cgtgcgcctg cctttcttgg actcacagac cggagtagcc cagagcaatt gttacatctg      300

gatggaaaag cgacaccggg gtccaggatt ggcctccgga cagctgtact cctaccctgc      360

ccggcgctgg cggaaaaagc ggcgagccca tccccctgag gatccacgac tttccttccc      420

atctattaag ccagacacag accagaccct gaagaaggag gggctgatct ctcaggatgg      480

cagtagttta gaggctctgt tgcgcactga ccccctggag aagcgaggtg ccccggatcc      540

ccgagttgat gatgacagcc tgggcgagtt tcctgtgacc aacagtcgag cgcgaaagcg      600

gatcctagaa ccagatgact tcctggatga cctcgatgat gaagactatg aagaagatac      660

tcccaagcgt cggggaaagg ggaaatccaa gggtaagggt gtgggcagtg cccgtaagaa      720

gctggatgct tccatcctgg aggaccggga taagccctat gcctgtgaca atagtttcaa      780

acaaaagcat acctcgaaag cgccccagag agtttgtgga aaacgttaca agaaccgacc      840

aggcctcagt taccactatg cccactccca cttggctgag gaggagggcg aggacaagga      900

agactctcaa ccacccactc ctgtttccca gaggtctgag gagcagaaat ccaaaaaggg      960

tcctgatgga ttggccttgc ccaacaacta ctgtgacttc tgcctggggg actcaaagat     1020

taacaagaag acgggacaac ccgaggagct ggtgtcctgt tctgactgtg gccgctcagg     1080

gcatccatct tgcctccaat ttacccccgt gatgatggcg gcagtgaaga cataccgctg     1140

gcagtgcatc gagtgcaaat gttgcaatat ctgcggcacc tccgagaatg acgaccagtt     1200

gctcttctgt gatgactgcg atcgtggcta ccacatgtac tgtctcaccc cgtccatgtc     1260

tgagccccct gaaggaagtt ggagctgcca cctgtgtctg gacctgttga aagagaaagc     1320

ttccatctac cagaaccaga actcctcttg atgtggccac ccacctgctc cccgacatat     1380

ctaaggctgt ttctctcctc cacttcatat ttcataccca tctttccctt cttcctcctc     1440

tccttcacaa atccagagaa ccttggggtg gttgtgccag cctgcctttg gcagctgcaa     1500

gctgaggtgg cagctctgac cacctctggc cccaggccct cagggagaaa ggagcaacac     1560

actgccccta ggcgtgcgtg tggcccagtt tctctctgct ctccattaag tgcattcact     1620

ctgcttgcct tgggcccagc ccctggtgat cacagggttc aaacagtgtc ctcctagaaa     1680

gagtgggaga gcagctcact tctctgtgtt ctgcctcccc tctggtctcc agagttttcc     1740

tgtcctctag aggcaagcca ggccagggag ctgggagcga gcaagctgag gccacgtcca     1800

caaggagctt ttcatgcccc tgtgccgcat agcctcacct ctttcctcca gagtggctct     1860

ctgcggccct gtgttcctgc tacagagtgt tcttttctgg agtcaggatg ttctcggtca     1920

ccctcctggt tctgccctgt cccattccac cccaccccag ggggaacagt agcttcacct     1980

tgttattccc attgctctcc tggctcactc ttacggtcgg tctccagtga ctgaagcatt     2040

ccccaccctt ggaatttctc atcttctgcc tcccttccta ctccttttgg ttttgtgggg     2100

agaggggaag gatcaggggg ccaggccagc agctcggggg ccacaaggag atggataatg     2160

tgcctgtttt ttaacacaac aaaaaagcct acctccaaaa tccccttttt gttcttcctg     2220

gacctgggca ttcagcctcc tgctcttaac tgaattggga gcctctgcca cctgccccgt     2280

gtatcctggc tctcagctca tggggaagcc acatagacat ccctttcttc ccttgcacgc     2340

tcgctagcag ctggtaaggt cttcacaccc tgattcctca agttttctgc ttagtggcac     2400

tgacattaag tagtgggggg acagtccatg ccaggacacc ctggagtagc cttccccctt     2460

ggccgtgggc aggccctaac tcactgtcgc tttggagttg aggtgtcttt tttttttctt     2520

tctttagttc ctgtattcta aacattagta aaaataaatg tttttacaca gagccctctg     2580

ctggatggtt tatctcctgc ctttctccat taagaaggcc atttcatcct aagatttcca     2640

tgatggtggt tttttttttt aatgttttga aatacagctt ttttcccccc aaattaaaat     2700

ttttttgtgg aaccccaata tgtaaagcga atataaaatt ggttattttg ttttgttaca     2760

taaattcaag tttataacaa ttctttgtta taaagaacaa tgaagctgtt ttgatcaata     2820

caaaatttgg gttaaaatca actttaacat ctatttttat gtttcagttg atttggagaa     2880

ttctcctagt cttggataca tagatggaag tgatgacagg tttataacag ttgaccttgc     2940

aatctcagac atttaaaaca ggaccagaag tttatataaa tataattaat aagcaaacta     3000

atgacatcac catgggacac acacaaaagt tcttgcagga gcagggtctg tgtggcttca     3060

gttgcctgca gcgctcccag gccagagcaa gtgctctagg atctgaactg cccgcagtgc     3120

agccctgcag cctttcccag ggcacgttga tgtgcacaca gtttccctga aggcaaagtg     3180

aacatgtgga gagcttacgt ggcagcgcgt atgtcttcag tgtgtgtttt agaagtccaa     3240

ctgttgtttt tatgttttta aaggaaagat ttgaatcaag cagttatggg ccccctgaag     3300

tatccttttt tctagaacat tctgaaagtc atccttgcct atgggaagcc taggccggcc     3360

tgcactgtta tgttcaataa ataagcaggg tgctctgggc tggggattgt gtgaggagca     3420

gagcgcagcc cgtcctcatg cttttccact gaagtaggcc aggcagagag ggagtacagc     3480

aatggatgcg ctttggcagc tgagtagtcc gagagccaga aaagaaatgt ggaaaataag     3540

aacgctgtag caggcctagg tgaggaaatt taggaagggt ttgcgggagg taggatttga     3600

gatgggtctt ggagagttgg acagtgtcag ccggtaggac gggggtgcgg acggaagcct     3660

gtgaggaagg cagaggatgc ggagctgtga gcggagggag cagcgaggct ggagagcagc     3720

tgggctgcgg gtcaagacgt ctgcgtttaa ttcgggactg aaggttagca gggaagggaa     3780

cgatgccaga tcttgagttt aagaacttga atcttgtaaa gtaccaaatc taataaaata     3840

ctcgtcctaa ataaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaa        3897


<210> 120
<211> 405
<212> PRT
<213> Homo sapiens

<400> 120
Met Ala Ala Val Val Glu Asn Val Val Lys Leu Leu Gly Glu Gln Tyr 
1               5                   10                  15      


Tyr Lys Asp Ala Met Glu Gln Cys His Asn Tyr Asn Ala Arg Leu Cys 
            20                  25                  30          


Ala Glu Arg Ser Val Arg Leu Pro Phe Leu Asp Ser Gln Thr Gly Val 
        35                  40                  45              


Ala Gln Ser Asn Cys Tyr Ile Trp Met Glu Lys Arg His Arg Gly Pro 
    50                  55                  60                  


Gly Leu Ala Ser Gly Gln Leu Tyr Ser Tyr Pro Ala Arg Arg Trp Arg 
65                  70                  75                  80  


Lys Lys Arg Arg Ala His Pro Pro Glu Asp Pro Arg Leu Ser Phe Pro 
                85                  90                  95      


Ser Ile Lys Pro Asp Thr Asp Gln Thr Leu Lys Lys Glu Gly Leu Ile 
            100                 105                 110         


Ser Gln Asp Gly Ser Ser Leu Glu Ala Leu Leu Arg Thr Asp Pro Leu 
        115                 120                 125             


Glu Lys Arg Gly Ala Pro Asp Pro Arg Val Asp Asp Asp Ser Leu Gly 
    130                 135                 140                 


Glu Phe Pro Val Thr Asn Ser Arg Ala Arg Lys Arg Ile Leu Glu Pro 
145                 150                 155                 160 


Asp Asp Phe Leu Asp Asp Leu Asp Asp Glu Asp Tyr Glu Glu Asp Thr 
                165                 170                 175     


Pro Lys Arg Arg Gly Lys Gly Lys Ser Lys Gly Lys Gly Val Gly Ser 
            180                 185                 190         


Ala Arg Lys Lys Leu Asp Ala Ser Ile Leu Glu Asp Arg Asp Lys Pro 
        195                 200                 205             


Tyr Ala Cys Asp Asn Ser Phe Lys Gln Lys His Thr Ser Lys Ala Pro 
    210                 215                 220                 


Gln Arg Val Cys Gly Lys Arg Tyr Lys Asn Arg Pro Gly Leu Ser Tyr 
225                 230                 235                 240 


His Tyr Ala His Ser His Leu Ala Glu Glu Glu Gly Glu Asp Lys Glu 
                245                 250                 255     


Asp Ser Gln Pro Pro Thr Pro Val Ser Gln Arg Ser Glu Glu Gln Lys 
            260                 265                 270         


Ser Lys Lys Gly Pro Asp Gly Leu Ala Leu Pro Asn Asn Tyr Cys Asp 
        275                 280                 285             


Phe Cys Leu Gly Asp Ser Lys Ile Asn Lys Lys Thr Gly Gln Pro Glu 
    290                 295                 300                 


Glu Leu Val Ser Cys Ser Asp Cys Gly Arg Ser Gly His Pro Ser Cys 
305                 310                 315                 320 


Leu Gln Phe Thr Pro Val Met Met Ala Ala Val Lys Thr Tyr Arg Trp 
                325                 330                 335     


Gln Cys Ile Glu Cys Lys Cys Cys Asn Ile Cys Gly Thr Ser Glu Asn 
            340                 345                 350         


Asp Asp Gln Leu Leu Phe Cys Asp Asp Cys Asp Arg Gly Tyr His Met 
        355                 360                 365             


Tyr Cys Leu Thr Pro Ser Met Ser Glu Pro Pro Glu Gly Ser Trp Ser 
    370                 375                 380                 


Cys His Leu Cys Leu Asp Leu Leu Lys Glu Lys Ala Ser Ile Tyr Gln 
385                 390                 395                 400 


Asn Gln Asn Ser Ser 
                405 


<210> 121
<211> 3356
<212> DNA
<213> Mus musculus

<400> 121
cctgcgcaga gggtcgagga ccctgtgtcc tgagaaggct tagcgcctgc gcgttgtagg       60

tttcggggcc tcccggcctg agggagagga acagggaaga tggcggctgt ggtggagaat      120

gtagtgaagc tccttggcga gcaatactac aaagatgcca tggaacagtg ccacaattat      180

aacgcccgcc tctgtgctga acgtagtgtg cgcctgcctt tcctggactc acagactgga      240

gtagcccaga gcaattgtta tatctggatg gaaaagcgac accggggacc aggattggcc      300

tctggacagt tatactccta tcctgccaga cgctggcgga aaaagcgccg agcccaccca      360

cctgaggatc ccaggctttc tttcccatcg attaaaccag acactgacca gactctgaag      420

aaagaggggc ttatctctca ggatggcagc agtttagagg ctctgttgcg tactgatccc      480

ctggagaaac ggggtgcccc agatccccga gttgacgatg acagcctggg cgagtttcct      540

gttagcaaca gtcgagcacg gaagcggatc attgaacccg atgacttcct tgatgacctt      600

gatgatgagg actatgaaga agatacgcca aagcgtcggg ggaaggggaa gtccaagagt      660

aagggtgtga gcagtgcccg gaagaagctg gatgcttcca tcctggagga ccgggataag      720

ccctatgcct gtgacaatag tttcaaacaa aagcatacct cgaaagcgcc ccagagagtt      780

tgtggaaaac gttacaagaa ccgacctggc ctcagttacc actatgccca ctcccacctg      840

gctgaagagg aaggagagga caaagaagac tcccgacccc ccactcctgt gtcccagagg      900

tctgaggagc agaaatccaa gaaaggacct gatggattgg ccctgcctaa caactactgt      960

gacttctgcc taggagactc aaaaatcaac aagaagacag ggcagcccga ggagctagtg     1020

tcctgttccg actgtggccg ctcagggcat ccgtcctgcc tgcagttcac ccctgtgatg     1080

atggcggccg tgaagaccta ccgctggcag tgcatcgaat gcaagtgctg caacctctgc     1140

ggcacgtcgg agaacgatga ccagctactt ttctgtgatg actgtgaccg tggctaccac     1200

atgtactgtc tcactccttc catgtctgag cctcctgaag gaagttggag ttgccacctg     1260

tgtctggatc tgctgaagga gaaagcatcc atctaccaga accagaactc ctcctgatgt     1320

gccacccagc tcccctgcat ctaaggccgt tgctctcctc tctaccttgg tttccattgc     1380

ccctctctcc tctttcactc tgtagtcctg ccaacctccg ttggcaacag cacagggagg     1440

tggcagctct gactgcctct agccccgagc cctcagggag taaggagcag cgtgctgctc     1500

cagggctgac ctgtgggtcc aacttctctc tgctctccaa gaagtgcatt cactctgcct     1560

gccttgggcc taagaccctg gtgattacag ggctcaaatg gggtcctctg agaaggaata     1620

tgagagcagc tcacttgtct caagccttgc ccacccctct tcccccaaac cccctttggt     1680

ttccagggtt ttgccccaga gatgagccag gctgggcctt tcctggaagc agctggagtg     1740

agctggctga gtggcacttg ccaggacctt ttcataccct agttctgctt ccctttgcct     1800

cctgccaaag cagtcccctg tcctctgtca tgctacatgg ggttctgtgc ttgagctaga     1860

atgttctcgg gcacctcctg gctctgccct gtcccacaaa gggacgagca gcttcaaacc     1920

tgtcctccct gtgcttggtg gcttgctcac aggtgcgctc tggctaccca gacatttcct     1980

atcctcagaa cttcccatct tctgccccca tccttagtcc ctttgctttt gtagggagag     2040

ggatagtgtc aggggctggg ccagcagctt gggggccaca gggagaagtt ggataatgtg     2100

cctgtttttt aactcgataa aaaagcctac ctccaaaatt ccctttttgt tcttcctgaa     2160

cctgggcatt cagcctcctg tccttaacta aattaggagc ctctgcctcc tgcctgtgta     2220

tcctggctcc caggacacag gatggtcccc tttccttgca cgctagctag tagctggtaa     2280

ggtcttcaca ccctgagttt tctgtttcct gcttagtggc actgacatta agtaggaggg     2340

gacagtcctc tgcagtactc tagagagtgg gcttccccct tggctgtggg caggccctaa     2400

ctgttttctg caaagttgag ggccccccct cgcatattta gttcctgtat tcaaaacatt     2460

agtaaaaata aacattttta cagagtcttc tgctggacag tttgtctctt gactccttgt     2520

tgaaaggttg tttcatttca aacttacgac aatagggttt tttgttggtg gtggttggtt     2580

gttttaaatt gaaacaactt tttctcccaa aatcaaagtt tttgttaaac tccaccatgt     2640

aaaattattt tgttagtttt gttatgtaaa ttcagattta taacaattta gtggtataaa     2700

ggatgaagct aattaataca aaaattgggt taaaatcaac tttagcattt tctctgtatc     2760

tgtgcttttg gctggttgga aagactttac tcggtgtgaa tatgtaggcg gaggtgcggc     2820

agatctatgg cactgcagtg tctcctggtt aaagtgaacc cagaagcttg tttgtgcttt     2880

aaactccaag gagttatgag ttaagcctgg agagagagcg cagcagagga gaggatgctc     2940

gttgttcttg cagagggcca agtttggttc ccagcactca aatccggtgg ctcacaacca     3000

cctgtagctc cagctccagg agctggggag gtcaactgtg ctcctgcaaa cacccacctg     3060

cccactcatc ttcatccatc tacaaaccta ccagtgtcat cgtagaacaa aagaagccga     3120

gaggagagta acctcagatc ctgtcatctg atgaaccttt tcattgcctg tcggattgct     3180

aagccaaagc agagttgcaa agccagaatt gtccacagtg cagggtgtca tgtgcagacc     3240

gtgagtgagt ttatatccag ccagattagt acttggatgt tatatagtgg atcttgtata     3300

gctcacttgg tatgtattaa cattttaact tttttctttt aaagatttat ttattt         3356


<210> 122
<211> 405
<212> PRT
<213> Mus musculus

<400> 122
Met Ala Ala Val Val Glu Asn Val Val Lys Leu Leu Gly Glu Gln Tyr 
1               5                   10                  15      


Tyr Lys Asp Ala Met Glu Gln Cys His Asn Tyr Asn Ala Arg Leu Cys 
            20                  25                  30          


Ala Glu Arg Ser Val Arg Leu Pro Phe Leu Asp Ser Gln Thr Gly Val 
        35                  40                  45              


Ala Gln Ser Asn Cys Tyr Ile Trp Met Glu Lys Arg His Arg Gly Pro 
    50                  55                  60                  


Gly Leu Ala Ser Gly Gln Leu Tyr Ser Tyr Pro Ala Arg Arg Trp Arg 
65                  70                  75                  80  


Lys Lys Arg Arg Ala His Pro Pro Glu Asp Pro Arg Leu Ser Phe Pro 
                85                  90                  95      


Ser Ile Lys Pro Asp Thr Asp Gln Thr Leu Lys Lys Glu Gly Leu Ile 
            100                 105                 110         


Ser Gln Asp Gly Ser Ser Leu Glu Ala Leu Leu Arg Thr Asp Pro Leu 
        115                 120                 125             


Glu Lys Arg Gly Ala Pro Asp Pro Arg Val Asp Asp Asp Ser Leu Gly 
    130                 135                 140                 


Glu Phe Pro Val Ser Asn Ser Arg Ala Arg Lys Arg Ile Ile Glu Pro 
145                 150                 155                 160 


Asp Asp Phe Leu Asp Asp Leu Asp Asp Glu Asp Tyr Glu Glu Asp Thr 
                165                 170                 175     


Pro Lys Arg Arg Gly Lys Gly Lys Ser Lys Ser Lys Gly Val Ser Ser 
            180                 185                 190         


Ala Arg Lys Lys Leu Asp Ala Ser Ile Leu Glu Asp Arg Asp Lys Pro 
        195                 200                 205             


Tyr Ala Cys Asp Asn Ser Phe Lys Gln Lys His Thr Ser Lys Ala Pro 
    210                 215                 220                 


Gln Arg Val Cys Gly Lys Arg Tyr Lys Asn Arg Pro Gly Leu Ser Tyr 
225                 230                 235                 240 


His Tyr Ala His Ser His Leu Ala Glu Glu Glu Gly Glu Asp Lys Glu 
                245                 250                 255     


Asp Ser Arg Pro Pro Thr Pro Val Ser Gln Arg Ser Glu Glu Gln Lys 
            260                 265                 270         


Ser Lys Lys Gly Pro Asp Gly Leu Ala Leu Pro Asn Asn Tyr Cys Asp 
        275                 280                 285             


Phe Cys Leu Gly Asp Ser Lys Ile Asn Lys Lys Thr Gly Gln Pro Glu 
    290                 295                 300                 


Glu Leu Val Ser Cys Ser Asp Cys Gly Arg Ser Gly His Pro Ser Cys 
305                 310                 315                 320 


Leu Gln Phe Thr Pro Val Met Met Ala Ala Val Lys Thr Tyr Arg Trp 
                325                 330                 335     


Gln Cys Ile Glu Cys Lys Cys Cys Asn Leu Cys Gly Thr Ser Glu Asn 
            340                 345                 350         


Asp Asp Gln Leu Leu Phe Cys Asp Asp Cys Asp Arg Gly Tyr His Met 
        355                 360                 365             


Tyr Cys Leu Thr Pro Ser Met Ser Glu Pro Pro Glu Gly Ser Trp Ser 
    370                 375                 380                 


Cys His Leu Cys Leu Asp Leu Leu Lys Glu Lys Ala Ser Ile Tyr Gln 
385                 390                 395                 400 


Asn Gln Asn Ser Ser 
                405 


<210> 123
<211> 3314
<212> DNA
<213> Mus musculus

<400> 123
cctgcgcaga gggtcgagga ccctgtgtcc tgagaaggct tagcgcctgc gcgttgtagg       60

tttcggggcc tcccggcctg agggagagga acagggaaga tggcggctgt ggtggagaat      120

gtagtgaagc tccttggcga gcaatactac aaagatgcca tggaacagtg ccacaattat      180

aacgcccgcc tctgtgctga acgtagtgtg cgcctgcctt tcctggactc acagactgga      240

gtagcccaga gcaattgtta tatctggatg gaaaagcgac accggggacc aggattggcc      300

tctggacagt tatactccta tcctgccaga cgctggcgga aaaagcgccg agcccaccca      360

cctgaggatc ccaggctttc tttcccatcg attaaaccag acactgacca gactctgaag      420

aaagaggggc ttatctctca ggatggcagc agtttagagg ctctgttgcg tactgatccc      480

ctggagaaac ggggtgcccc agatccccga gttgacgatg acagcctggg cgagtttcct      540

gttagcaaca gtcgagcacg gaagcggatc attgaacccg atgacttcct tgatgacctt      600

gatgatgagg actatgaaga agatacgcca aagcgtcggg ggaaggggaa gtccaagagt      660

aagggtgtga gcagtgcccg gaagaagctg gatgcttcca tcctggagga ccgggataag      720

ccctatgcct gtgacatttg tggaaaacgt tacaagaacc gacctggcct cagttaccac      780

tatgcccact cccacctggc tgaagaggaa ggagaggaca aagaagactc ccgacccccc      840

actcctgtgt cccagaggtc tgaggagcag aaatccaaga aaggacctga tggattggcc      900

ctgcctaaca actactgtga cttctgccta ggagactcaa aaatcaacaa gaagacaggg      960

cagcccgagg agctagtgtc ctgttccgac tgtggccgct cagggcatcc gtcctgcctg     1020

cagttcaccc ctgtgatgat ggcggccgtg aagacctacc gctggcagtg catcgaatgc     1080

aagtgctgca acctctgcgg cacgtcggag aacgatgacc agctactttt ctgtgatgac     1140

tgtgaccgtg gctaccacat gtactgtctc actccttcca tgtctgagcc tcctgaagga     1200

agttggagtt gccacctgtg tctggatctg ctgaaggaga aagcatccat ctaccagaac     1260

cagaactcct cctgatgtgc cacccagctc ccctgcatct aaggccgttg ctctcctctc     1320

taccttggtt tccattgccc ctctctcctc tttcactctg tagtcctgcc aacctccgtt     1380

ggcaacagca cagggaggtg gcagctctga ctgcctctag ccccgagccc tcagggagta     1440

aggagcagcg tgctgctcca gggctgacct gtgggtccaa cttctctctg ctctccaaga     1500

agtgcattca ctctgcctgc cttgggccta agaccctggt gattacaggg ctcaaatggg     1560

gtcctctgag aaggaatatg agagcagctc acttgtctca agccttgccc acccctcttc     1620

ccccaaaccc cctttggttt ccagggtttt gccccagaga tgagccaggc tgggcctttc     1680

ctggaagcag ctggagtgag ctggctgagt ggcacttgcc aggacctttt cataccctag     1740

ttctgcttcc ctttgcctcc tgccaaagca gtcccctgtc ctctgtcatg ctacatgggg     1800

ttctgtgctt gagctagaat gttctcgggc acctcctggc tctgccctgt cccacaaagg     1860

gacgagcagc ttcaaacctg tcctccctgt gcttggtggc ttgctcacag gtgcgctctg     1920

gctacccaga catttcctat cctcagaact tcccatcttc tgcccccatc cttagtccct     1980

ttgcttttgt agggagaggg atagtgtcag gggctgggcc agcagcttgg gggccacagg     2040

gagaagttgg ataatgtgcc tgttttttaa ctcgataaaa aagcctacct ccaaaattcc     2100

ctttttgttc ttcctgaacc tgggcattca gcctcctgtc cttaactaaa ttaggagcct     2160

ctgcctcctg cctgtgtatc ctggctccca ggacacagga tggtcccctt tccttgcacg     2220

ctagctagta gctggtaagg tcttcacacc ctgagttttc tgtttcctgc ttagtggcac     2280

tgacattaag taggagggga cagtcctctg cagtactcta gagagtgggc ttcccccttg     2340

gctgtgggca ggccctaact gttttctgca aagttgaggg ccccccctcg catatttagt     2400

tcctgtattc aaaacattag taaaaataaa catttttaca gagtcttctg ctggacagtt     2460

tgtctcttga ctccttgttg aaaggttgtt tcatttcaaa cttacgacaa tagggttttt     2520

tgttggtggt ggttggttgt tttaaattga aacaactttt tctcccaaaa tcaaagtttt     2580

tgttaaactc caccatgtaa aattattttg ttagttttgt tatgtaaatt cagatttata     2640

acaatttagt ggtataaagg atgaagctaa ttaatacaaa aattgggtta aaatcaactt     2700

tagcattttc tctgtatctg tgcttttggc tggttggaaa gactttactc ggtgtgaata     2760

tgtaggcgga ggtgcggcag atctatggca ctgcagtgtc tcctggttaa agtgaaccca     2820

gaagcttgtt tgtgctttaa actccaagga gttatgagtt aagcctggag agagagcgca     2880

gcagaggaga ggatgctcgt tgttcttgca gagggccaag tttggttccc agcactcaaa     2940

tccggtggct cacaaccacc tgtagctcca gctccaggag ctggggaggt caactgtgct     3000

cctgcaaaca cccacctgcc cactcatctt catccatcta caaacctacc agtgtcatcg     3060

tagaacaaaa gaagccgaga ggagagtaac ctcagatcct gtcatctgat gaaccttttc     3120

attgcctgtc ggattgctaa gccaaagcag agttgcaaag ccagaattgt ccacagtgca     3180

gggtgtcatg tgcagaccgt gagtgagttt atatccagcc agattagtac ttggatgtta     3240

tatagtggat cttgtatagc tcacttggta tgtattaaca ttttaacttt tttcttttaa     3300

agatttattt attt                                                       3314


<210> 124
<211> 391
<212> PRT
<213> Mus musculus

<400> 124
Met Ala Ala Val Val Glu Asn Val Val Lys Leu Leu Gly Glu Gln Tyr 
1               5                   10                  15      


Tyr Lys Asp Ala Met Glu Gln Cys His Asn Tyr Asn Ala Arg Leu Cys 
            20                  25                  30          


Ala Glu Arg Ser Val Arg Leu Pro Phe Leu Asp Ser Gln Thr Gly Val 
        35                  40                  45              


Ala Gln Ser Asn Cys Tyr Ile Trp Met Glu Lys Arg His Arg Gly Pro 
    50                  55                  60                  


Gly Leu Ala Ser Gly Gln Leu Tyr Ser Tyr Pro Ala Arg Arg Trp Arg 
65                  70                  75                  80  


Lys Lys Arg Arg Ala His Pro Pro Glu Asp Pro Arg Leu Ser Phe Pro 
                85                  90                  95      


Ser Ile Lys Pro Asp Thr Asp Gln Thr Leu Lys Lys Glu Gly Leu Ile 
            100                 105                 110         


Ser Gln Asp Gly Ser Ser Leu Glu Ala Leu Leu Arg Thr Asp Pro Leu 
        115                 120                 125             


Glu Lys Arg Gly Ala Pro Asp Pro Arg Val Asp Asp Asp Ser Leu Gly 
    130                 135                 140                 


Glu Phe Pro Val Ser Asn Ser Arg Ala Arg Lys Arg Ile Ile Glu Pro 
145                 150                 155                 160 


Asp Asp Phe Leu Asp Asp Leu Asp Asp Glu Asp Tyr Glu Glu Asp Thr 
                165                 170                 175     


Pro Lys Arg Arg Gly Lys Gly Lys Ser Lys Ser Lys Gly Val Ser Ser 
            180                 185                 190         


Ala Arg Lys Lys Leu Asp Ala Ser Ile Leu Glu Asp Arg Asp Lys Pro 
        195                 200                 205             


Tyr Ala Cys Asp Ile Cys Gly Lys Arg Tyr Lys Asn Arg Pro Gly Leu 
    210                 215                 220                 


Ser Tyr His Tyr Ala His Ser His Leu Ala Glu Glu Glu Gly Glu Asp 
225                 230                 235                 240 


Lys Glu Asp Ser Arg Pro Pro Thr Pro Val Ser Gln Arg Ser Glu Glu 
                245                 250                 255     


Gln Lys Ser Lys Lys Gly Pro Asp Gly Leu Ala Leu Pro Asn Asn Tyr 
            260                 265                 270         


Cys Asp Phe Cys Leu Gly Asp Ser Lys Ile Asn Lys Lys Thr Gly Gln 
        275                 280                 285             


Pro Glu Glu Leu Val Ser Cys Ser Asp Cys Gly Arg Ser Gly His Pro 
    290                 295                 300                 


Ser Cys Leu Gln Phe Thr Pro Val Met Met Ala Ala Val Lys Thr Tyr 
305                 310                 315                 320 


Arg Trp Gln Cys Ile Glu Cys Lys Cys Cys Asn Leu Cys Gly Thr Ser 
                325                 330                 335     


Glu Asn Asp Asp Gln Leu Leu Phe Cys Asp Asp Cys Asp Arg Gly Tyr 
            340                 345                 350         


His Met Tyr Cys Leu Thr Pro Ser Met Ser Glu Pro Pro Glu Gly Ser 
        355                 360                 365             


Trp Ser Cys His Leu Cys Leu Asp Leu Leu Lys Glu Lys Ala Ser Ile 
    370                 375                 380                 


Tyr Gln Asn Gln Asn Ser Ser 
385                 390     


<210> 125
<211> 4077
<212> DNA
<213> Homo sapiens

<400> 125
agacaatatt ctgttacatt gtagcaaaat ggcgactgtc attcacaacc ccctgaaagc       60

gctcggggac cagttctaca aggaagccat tgagcactgc cggagttaca actcacggct      120

gtgtgcagag cgcagcgtgc gtcttccctt cctggactca cagactgggg tggcccagaa      180

caactgctac atctggatgg agaagaggca ccgaggccca ggccttgccc cgggccagct      240

gtatacatac cctgcccgct gctggcgcaa gaagagacga ttgcacccac ctgaagatcc      300

aaaactgcgg ctgctggaga taaaacctga agtggagctt cccctgaaga aggatgggtt      360

cacctcagag agcaccacgc tggaagcctt gctccgtggc gagggggttg agaagaaggt      420

ggatgccagg gaggaggaaa gcatccagga aatacagagg gttttggaaa atgatgaaaa      480

tgtagaagaa gggaatgaag aagaggattt ggaagaggat attcccaagc gaaagaacag      540

gactagagga cgggctcgcg gctctgcagg gggcaggagg aggcacgacg ccgcctctca      600

ggaagaccac gacaaacctt acgtctgtga catctgtggc aagcgctaca agaaccgacc      660

ggggctcagc taccactatg ctcacactca cctggccagc gaggaggggg atgaagctca      720

agaccaggag actcggtccc cacccaacca cagaaatgag aaccacaggc cccagaaagg      780

accggatgga acagtcattc ccaataacta ctgtgacttc tgcttggggg gctccaacat      840

gaacaagaag agtgggcggc ctgaagagct ggtgtcctgc gcagactgtg gacgctctgc      900

tcatttggga ggagaaggca ggaaggagaa ggaggcagcg gccgcagcac gtaccacgga      960

ggacttattc ggttccacgt cagaaagtga cacgtcaact ttccacggct ttgatgagga     1020

cgatttggaa gagcctcgct cctgtcgagg acgccgcagt ggccggggtt cgcccacagc     1080

agataaaaag ggcagttgct aaacccacgg aacagactct ctgggcaatt agccatcccc     1140

ctctgacttt ggtcattgtg ctggttctga tatatatttt ttttaatgaa aggcaacttt     1200

agattttccc tctatccttg ctttttttcc cttcacctcc cacgtgtccc tccatccctc     1260

cccccacccc tctgttttgg gtatgtacaa cagaagcaca aactactgaa acaaaacaaa     1320

acagcagaat gagcgttctt ccgagagatg gcatcgtgat gcgctattta ttttccatag     1380

aaataggaag ttagacggat tgtctctttt ctgaggggag ggggtctttt tgacaggagc     1440

agagttgatg tcctcaattt tcatatttat tggcaaaagg aagagaagag gaactttggg     1500

ttggaaacaa agaaccaata acattaaaac attattattt atatattcta gctgttatta     1560

gaatcagact ttttttgcga gagagagaga gagagagaga gaagggaaat caaagaaatc     1620

gaagcaatat cctgtttaga ggcaagccgc ccggtgggga gaatttcctc aatgggagac     1680

ggttgcacta ttctgtgccc cacggagttt gcggctcccc gcggcagacc cctccctcat     1740

tctcctccct gacctttcca tcttcctctc tgcttgcgag aaaatgtcag tagttccaga     1800

gaagtcgggg tgcctatgcc tggcctccct ccacacctgg gccctgacca gccgcctcct     1860

gggctcctcc tcctccgtca gtagagctgc tgttttgtta ttgctggttt ttcctcactt     1920

tcctcctggc aaagaacgac ttccaaatgc agggatggaa tataagcaga acgtcatggg     1980

ctcagcagtg actccaccac ccgaggccga ggccgtgctt ctggaagata gaaggagaca     2040

tcatcgtgtg tttcccctcc ccttgcccct gttaagaaac gtatcaatac ccattggatg     2100

atcaaggcta ccgtatttct tctatttttt tttatagtgc ctgccaggca ctttgtttta     2160

tgtttccaat agcacttcct gaaataaacc aaagcaacac tgctcaaggc ccctggggcg     2220

atggagaagg ccacccacct cactgacagt cccaagaatg accggctgcg aggtcctagt     2280

caaaagtcaa cattatgacc tggggactcc agcatccttc aagcaagcca tttccgaaga     2340

aggtgaaaag aagccaggat gattggcacc tcctcctcct cctcctcttc ttcctcttcc     2400

cttgcccagc cccctcctgt gcgtgtgttt cagacaacac aggagccagc acaggagtgg     2460

aaaatcctgc agcgcaactc agctcagccc acagaagcct tgggaatggc ctcagtttgt     2520

gcaataagaa gatttttttt ttctttttaa atcttcatta tattttcttt gattgtctgt     2580

gagaaagtac ccaggtccgc ctggaattac tctacagtag aaataactga acacaaacaa     2640

actgatggaa aaaaagagtt aactatttta tttatttcaa tatttaaaag gaaaaaagtg     2700

ctgacatggc acagtatttt tgtttaaagt acctcctact tcaaaagtta agcgcaattt     2760

tgtgaagaca tgaaatcata agagtactta atgtaaaata aaagactgca tattaactct     2820

aaagaaaaat gccccacatt ttaaataaga aaataaagat caactctgct ctctcaggct     2880

ttttaaaaag ccattcatgt atgtgcttta ggtattttta tttctgcgag ttggatgtgg     2940

taagtgagga gtgctcagtt tttttttcct ccttcaaaag tctattgaaa gtgttggtga     3000

tgttaaatga ttgtgtgtta agatttgact gaaataactt agccacaaat cagcagtttc     3060

ccccaccctc attgccccct caccccaggc aagccccttt tatctgaatg tcagaagcag     3120

cctgcctcct agttatcatg tctgatgagg tctagctcag gaaggaattc catctattga     3180

tggaatatat cccctcaagt tcaatagatt cgaacacaga gagctttgtt taaaataatg     3240

cagcaaaaaa aaaaaaaaaa aaaaagcaaa aataaaagca tcagctgagg tgatattagt     3300

tcagtcacct aacaactcct agaagagatg aggaaaggga accttctgct gagctggctt     3360

ctggggcctg agcttccaga gctgtcccca agggctagga aggccgacct gaaggatgag     3420

aacctcaaat tcagttgctg gtgggagcca aggaagacgg cgggtgttct aacatggccc     3480

tttctggctg agctggcgga agtgggcgtt ttggccgatg ggatgtatct cggcgctgtg     3540

tctgtggccc agcaaaggtg cagggctgac tggctgagcc actgggttct acccgcaggc     3600

tccccactgc actgggcttt cacacagcca tgctcttggg tttccctccc ttgtaagcag     3660

agtcataata acacacgaat agtctaaggc tgggtattct ggtcagcaga ggtccttgag     3720

tcacagtgtt actgaaatgg ttctgagcct gagaatctct ttggcctctg aaagggcagg     3780

gcaggtgggc accgacttcc tgccagtcct ttcaggtttc ctgttcaaag ccagtcctgt     3840

tggtggaggg gatcaccgag agtgtctgta tcattttgta gcccttttct ctgacgtttt     3900

ctggtagaaa atgtcccttg tcaaaatgct aataattatc ataataatct gctttccaac     3960

caactcccac aagtgacaac ctgtgtagaa ctgtgataaa ggtttgcata atgtagggtt     4020

tgtaccaagt gtgtgtaagt ttctgttaaa taaaaagtct gtttccaatg ctcctat        4077


<210> 126
<211> 357
<212> PRT
<213> Homo sapiens

<400> 126
Met Ala Thr Val Ile His Asn Pro Leu Lys Ala Leu Gly Asp Gln Phe 
1               5                   10                  15      


Tyr Lys Glu Ala Ile Glu His Cys Arg Ser Tyr Asn Ser Arg Leu Cys 
            20                  25                  30          


Ala Glu Arg Ser Val Arg Leu Pro Phe Leu Asp Ser Gln Thr Gly Val 
        35                  40                  45              


Ala Gln Asn Asn Cys Tyr Ile Trp Met Glu Lys Arg His Arg Gly Pro 
    50                  55                  60                  


Gly Leu Ala Pro Gly Gln Leu Tyr Thr Tyr Pro Ala Arg Cys Trp Arg 
65                  70                  75                  80  


Lys Lys Arg Arg Leu His Pro Pro Glu Asp Pro Lys Leu Arg Leu Leu 
                85                  90                  95      


Glu Ile Lys Pro Glu Val Glu Leu Pro Leu Lys Lys Asp Gly Phe Thr 
            100                 105                 110         


Ser Glu Ser Thr Thr Leu Glu Ala Leu Leu Arg Gly Glu Gly Val Glu 
        115                 120                 125             


Lys Lys Val Asp Ala Arg Glu Glu Glu Ser Ile Gln Glu Ile Gln Arg 
    130                 135                 140                 


Val Leu Glu Asn Asp Glu Asn Val Glu Glu Gly Asn Glu Glu Glu Asp 
145                 150                 155                 160 


Leu Glu Glu Asp Ile Pro Lys Arg Lys Asn Arg Thr Arg Gly Arg Ala 
                165                 170                 175     


Arg Gly Ser Ala Gly Gly Arg Arg Arg His Asp Ala Ala Ser Gln Glu 
            180                 185                 190         


Asp His Asp Lys Pro Tyr Val Cys Asp Ile Cys Gly Lys Arg Tyr Lys 
        195                 200                 205             


Asn Arg Pro Gly Leu Ser Tyr His Tyr Ala His Thr His Leu Ala Ser 
    210                 215                 220                 


Glu Glu Gly Asp Glu Ala Gln Asp Gln Glu Thr Arg Ser Pro Pro Asn 
225                 230                 235                 240 


His Arg Asn Glu Asn His Arg Pro Gln Lys Gly Pro Asp Gly Thr Val 
                245                 250                 255     


Ile Pro Asn Asn Tyr Cys Asp Phe Cys Leu Gly Gly Ser Asn Met Asn 
            260                 265                 270         


Lys Lys Ser Gly Arg Pro Glu Glu Leu Val Ser Cys Ala Asp Cys Gly 
        275                 280                 285             


Arg Ser Ala His Leu Gly Gly Glu Gly Arg Lys Glu Lys Glu Ala Ala 
    290                 295                 300                 


Ala Ala Ala Arg Thr Thr Glu Asp Leu Phe Gly Ser Thr Ser Glu Ser 
305                 310                 315                 320 


Asp Thr Ser Thr Phe His Gly Phe Asp Glu Asp Asp Leu Glu Glu Pro 
                325                 330                 335     


Arg Ser Cys Arg Gly Arg Arg Ser Gly Arg Gly Ser Pro Thr Ala Asp 
            340                 345                 350         


Lys Lys Gly Ser Cys 
        355         


<210> 127
<211> 1166
<212> DNA
<213> Homo sapiens

<400> 127
agacaatatt ctgttacatt gtagcaaaat ggcgactgtc attcacaacc ccctgaaagc       60

gctcggggac cagttctaca aggaagccat tgagcactgc cggagttaca actcacggct      120

gtgtgcagag cgcagcgtgc gtcttccctt cctggactca cagactgggg tggcccagaa      180

caactgctac atctggatgg agaagaggca ccgaggccca ggccttgccc cgggccagct      240

gtatacatac cctgcccgct gctggcgcaa gaagagacga ttgcacccac ctgaagatcc      300

aaaactgcgg ctgctggaga taaaacctga agtggagctt cccctgaaga aggatgggtt      360

cacctcagag agcaccacgc tggaagcctt gctccgtggc gagggggttg agaagaaggt      420

ggatgccagg gaggaggaaa gcatccagga aatacagagg gttttggaaa atgatgaaaa      480

tgtagaagaa gggaatgaag aagaggattt ggaagaggat attcccaagc gaaagaacag      540

gactagagga cgggctcgcg gctctgcagg gggcaggagg aggcacgacg ccgcctctca      600

ggaagaccac gacaaacctt acgtctgtga catctgtggc aagcgctaca agaaccgacc      660

ggggctcagc taccactatg ctcacactca cctggccagc gaggaggggg atgaagctca      720

agaccaggag actcggtccc cacccaacca cagaaatgag aaccacaggc cccagaaagg      780

accggatgga acagtcattc ccaataacta ctgtgacttc tgcttggggg gctccaacat      840

gaacaagaag agtgggcggc ctgaagagct ggtgtcctgc gcagactgtg gacgctctgg      900

tcacccaacc tgcctgcagt ttaccctgaa catgaccgag gctgtcaaga cctacaagtg      960

gcagtgcata gagtgcaaat cctgtatcct ctgtgggacc tcagagaatg atgaccagct     1020

actcttctgc gatgactgtg accgaggcta tcacatgtac tgtttaaatc ccccggtggc     1080

tgagccccca gaaggaagct ggagctgcca cttatgctgg gaactgctca aagagaaagc     1140

ctcagccttt ggctgccagg cctagg                                          1166


<210> 128
<211> 378
<212> PRT
<213> Homo sapiens

<400> 128
Met Ala Thr Val Ile His Asn Pro Leu Lys Ala Leu Gly Asp Gln Phe 
1               5                   10                  15      


Tyr Lys Glu Ala Ile Glu His Cys Arg Ser Tyr Asn Ser Arg Leu Cys 
            20                  25                  30          


Ala Glu Arg Ser Val Arg Leu Pro Phe Leu Asp Ser Gln Thr Gly Val 
        35                  40                  45              


Ala Gln Asn Asn Cys Tyr Ile Trp Met Glu Lys Arg His Arg Gly Pro 
    50                  55                  60                  


Gly Leu Ala Pro Gly Gln Leu Tyr Thr Tyr Pro Ala Arg Cys Trp Arg 
65                  70                  75                  80  


Lys Lys Arg Arg Leu His Pro Pro Glu Asp Pro Lys Leu Arg Leu Leu 
                85                  90                  95      


Glu Ile Lys Pro Glu Val Glu Leu Pro Leu Lys Lys Asp Gly Phe Thr 
            100                 105                 110         


Ser Glu Ser Thr Thr Leu Glu Ala Leu Leu Arg Gly Glu Gly Val Glu 
        115                 120                 125             


Lys Lys Val Asp Ala Arg Glu Glu Glu Ser Ile Gln Glu Ile Gln Arg 
    130                 135                 140                 


Val Leu Glu Asn Asp Glu Asn Val Glu Glu Gly Asn Glu Glu Glu Asp 
145                 150                 155                 160 


Leu Glu Glu Asp Ile Pro Lys Arg Lys Asn Arg Thr Arg Gly Arg Ala 
                165                 170                 175     


Arg Gly Ser Ala Gly Gly Arg Arg Arg His Asp Ala Ala Ser Gln Glu 
            180                 185                 190         


Asp His Asp Lys Pro Tyr Val Cys Asp Ile Cys Gly Lys Arg Tyr Lys 
        195                 200                 205             


Asn Arg Pro Gly Leu Ser Tyr His Tyr Ala His Thr His Leu Ala Ser 
    210                 215                 220                 


Glu Glu Gly Asp Glu Ala Gln Asp Gln Glu Thr Arg Ser Pro Pro Asn 
225                 230                 235                 240 


His Arg Asn Glu Asn His Arg Pro Gln Lys Gly Pro Asp Gly Thr Val 
                245                 250                 255     


Ile Pro Asn Asn Tyr Cys Asp Phe Cys Leu Gly Gly Ser Asn Met Asn 
            260                 265                 270         


Lys Lys Ser Gly Arg Pro Glu Glu Leu Val Ser Cys Ala Asp Cys Gly 
        275                 280                 285             


Arg Ser Gly His Pro Thr Cys Leu Gln Phe Thr Leu Asn Met Thr Glu 
    290                 295                 300                 


Ala Val Lys Thr Tyr Lys Trp Gln Cys Ile Glu Cys Lys Ser Cys Ile 
305                 310                 315                 320 


Leu Cys Gly Thr Ser Glu Asn Asp Asp Gln Leu Leu Phe Cys Asp Asp 
                325                 330                 335     


Cys Asp Arg Gly Tyr His Met Tyr Cys Leu Asn Pro Pro Val Ala Glu 
            340                 345                 350         


Pro Pro Glu Gly Ser Trp Ser Cys His Leu Cys Trp Glu Leu Leu Lys 
        355                 360                 365             


Glu Lys Ala Ser Ala Phe Gly Cys Gln Ala 
    370                 375             


<210> 129
<211> 4221
<212> DNA
<213> Homo sapiens

<400> 129
agacaatatt ctgttacatt gtagcaaaat ggcgactgtc attcacaacc ccctgaaagc       60

gccctttcaa gaatcctatg aaagttgtgg atcatctccc cggaaaacac gcatatagat      120

gtgaacatct gcctatggtt ttatggggtt cacagacctg gaagagccca tctctggatg      180

ccctggaggc ccatgggctc tagggctcgg ggaccagttc tacaaggaag ccattgagca      240

ctgccggagt tacaactcac ggctgtgtgc agagcgcagc gtgcgtcttc ccttcctgga      300

ctcacagact ggggtggccc agaacaactg ctacatctgg atggagaaga ggcaccgagg      360

cccaggcctt gccccgggcc agctgtatac ataccctgcc cgctgctggc gcaagaagag      420

acgattgcac ccacctgaag atccaaaact gcggctgctg gagataaaac ctgaagtgga      480

gcttcccctg aagaaggatg ggttcacctc agagagcacc acgctggaag ccttgctccg      540

tggcgagggg gttgagaaga aggtggatgc cagggaggag gaaagcatcc aggaaataca      600

gagggttttg gaaaatgatg aaaatgtaga agaagggaat gaagaagagg atttggaaga      660

ggatattccc aagcgaaaga acaggactag aggacgggct cgcggctctg cagggggcag      720

gaggaggcac gacgccgcct ctcaggaaga ccacgacaaa ccttacgtct gtgacatctg      780

tggcaagcgc tacaagaacc gaccggggct cagctaccac tatgctcaca ctcacctggc      840

cagcgaggag ggggatgaag ctcaagacca ggagactcgg tccccaccca accacagaaa      900

tgagaaccac aggccccaga aaggaccgga tggaacagtc attcccaata actactgtga      960

cttctgcttg gggggctcca acatgaacaa gaagagtggg cggcctgaag agctggtgtc     1020

ctgcgcagac tgtggacgct ctgctcattt gggaggagaa ggcaggaagg agaaggaggc     1080

agcggccgca gcacgtacca cggaggactt attcggttcc acgtcagaaa gtgacacgtc     1140

aactttccac ggctttgatg aggacgattt ggaagagcct cgctcctgtc gaggacgccg     1200

cagtggccgg ggttcgccca cagcagataa aaagggcagt tgctaaaccc acggaacaga     1260

ctctctgggc aattagccat ccccctctga ctttggtcat tgtgctggtt ctgatatata     1320

ttttttttaa tgaaaggcaa ctttagattt tccctctatc cttgcttttt ttcccttcac     1380

ctcccacgtg tccctccatc cctcccccca cccctctgtt ttgggtatgt acaacagaag     1440

cacaaactac tgaaacaaaa caaaacagca gaatgagcgt tcttccgaga gatggcatcg     1500

tgatgcgcta tttattttcc atagaaatag gaagttagac ggattgtctc ttttctgagg     1560

ggagggggtc tttttgacag gagcagagtt gatgtcctca attttcatat ttattggcaa     1620

aaggaagaga agaggaactt tgggttggaa acaaagaacc aataacatta aaacattatt     1680

atttatatat tctagctgtt attagaatca gacttttttt gcgagagaga gagagagaga     1740

gagagaaggg aaatcaaaga aatcgaagca atatcctgtt tagaggcaag ccgcccggtg     1800

gggagaattt cctcaatggg agacggttgc actattctgt gccccacgga gtttgcggct     1860

ccccgcggca gacccctccc tcattctcct ccctgacctt tccatcttcc tctctgcttg     1920

cgagaaaatg tcagtagttc cagagaagtc ggggtgccta tgcctggcct ccctccacac     1980

ctgggccctg accagccgcc tcctgggctc ctcctcctcc gtcagtagag ctgctgtttt     2040

gttattgctg gtttttcctc actttcctcc tggcaaagaa cgacttccaa atgcagggat     2100

ggaatataag cagaacgtca tgggctcagc agtgactcca ccacccgagg ccgaggccgt     2160

gcttctggaa gatagaagga gacatcatcg tgtgtttccc ctccccttgc ccctgttaag     2220

aaacgtatca atacccattg gatgatcaag gctaccgtat ttcttctatt tttttttata     2280

gtgcctgcca ggcactttgt tttatgtttc caatagcact tcctgaaata aaccaaagca     2340

acactgctca aggcccctgg ggcgatggag aaggccaccc acctcactga cagtcccaag     2400

aatgaccggc tgcgaggtcc tagtcaaaag tcaacattat gacctgggga ctccagcatc     2460

cttcaagcaa gccatttccg aagaaggtga aaagaagcca ggatgattgg cacctcctcc     2520

tcctcctcct cttcttcctc ttcccttgcc cagccccctc ctgtgcgtgt gtttcagaca     2580

acacaggagc cagcacagga gtggaaaatc ctgcagcgca actcagctca gcccacagaa     2640

gccttgggaa tggcctcagt ttgtgcaata agaagatttt ttttttcttt ttaaatcttc     2700

attatatttt ctttgattgt ctgtgagaaa gtacccaggt ccgcctggaa ttactctaca     2760

gtagaaataa ctgaacacaa acaaactgat ggaaaaaaag agttaactat tttatttatt     2820

tcaatattta aaaggaaaaa agtgctgaca tggcacagta tttttgttta aagtacctcc     2880

tacttcaaaa gttaagcgca attttgtgaa gacatgaaat cataagagta cttaatgtaa     2940

aataaaagac tgcatattaa ctctaaagaa aaatgcccca cattttaaat aagaaaataa     3000

agatcaactc tgctctctca ggctttttaa aaagccattc atgtatgtgc tttaggtatt     3060

tttatttctg cgagttggat gtggtaagtg aggagtgctc agtttttttt tcctccttca     3120

aaagtctatt gaaagtgttg gtgatgttaa atgattgtgt gttaagattt gactgaaata     3180

acttagccac aaatcagcag tttcccccac cctcattgcc ccctcacccc aggcaagccc     3240

cttttatctg aatgtcagaa gcagcctgcc tcctagttat catgtctgat gaggtctagc     3300

tcaggaagga attccatcta ttgatggaat atatcccctc aagttcaata gattcgaaca     3360

cagagagctt tgtttaaaat aatgcagcaa aaaaaaaaaa aaaaaaaaag caaaaataaa     3420

agcatcagct gaggtgatat tagttcagtc acctaacaac tcctagaaga gatgaggaaa     3480

gggaaccttc tgctgagctg gcttctgggg cctgagcttc cagagctgtc cccaagggct     3540

aggaaggccg acctgaagga tgagaacctc aaattcagtt gctggtggga gccaaggaag     3600

acggcgggtg ttctaacatg gccctttctg gctgagctgg cggaagtggg cgttttggcc     3660

gatgggatgt atctcggcgc tgtgtctgtg gcccagcaaa ggtgcagggc tgactggctg     3720

agccactggg ttctacccgc aggctcccca ctgcactggg ctttcacaca gccatgctct     3780

tgggtttccc tcccttgtaa gcagagtcat aataacacac gaatagtcta aggctgggta     3840

ttctggtcag cagaggtcct tgagtcacag tgttactgaa atggttctga gcctgagaat     3900

ctctttggcc tctgaaaggg cagggcaggt gggcaccgac ttcctgccag tcctttcagg     3960

tttcctgttc aaagccagtc ctgttggtgg aggggatcac cgagagtgtc tgtatcattt     4020

tgtagccctt ttctctgacg ttttctggta gaaaatgtcc cttgtcaaaa tgctaataat     4080

tatcataata atctgctttc caaccaactc ccacaagtga caacctgtgt agaactgtga     4140

taaaggtttg cataatgtag ggtttgtacc aagtgtgtgt aagtttctgt taaataaaaa     4200

gtctgtttcc aatgctccta t                                               4221


<210> 130
<211> 367
<212> PRT
<213> Homo sapiens

<400> 130
Met Gly Phe Thr Asp Leu Glu Glu Pro Ile Ser Gly Cys Pro Gly Gly 
1               5                   10                  15      


Pro Trp Ala Leu Gly Leu Gly Asp Gln Phe Tyr Lys Glu Ala Ile Glu 
            20                  25                  30          


His Cys Arg Ser Tyr Asn Ser Arg Leu Cys Ala Glu Arg Ser Val Arg 
        35                  40                  45              


Leu Pro Phe Leu Asp Ser Gln Thr Gly Val Ala Gln Asn Asn Cys Tyr 
    50                  55                  60                  


Ile Trp Met Glu Lys Arg His Arg Gly Pro Gly Leu Ala Pro Gly Gln 
65                  70                  75                  80  


Leu Tyr Thr Tyr Pro Ala Arg Cys Trp Arg Lys Lys Arg Arg Leu His 
                85                  90                  95      


Pro Pro Glu Asp Pro Lys Leu Arg Leu Leu Glu Ile Lys Pro Glu Val 
            100                 105                 110         


Glu Leu Pro Leu Lys Lys Asp Gly Phe Thr Ser Glu Ser Thr Thr Leu 
        115                 120                 125             


Glu Ala Leu Leu Arg Gly Glu Gly Val Glu Lys Lys Val Asp Ala Arg 
    130                 135                 140                 


Glu Glu Glu Ser Ile Gln Glu Ile Gln Arg Val Leu Glu Asn Asp Glu 
145                 150                 155                 160 


Asn Val Glu Glu Gly Asn Glu Glu Glu Asp Leu Glu Glu Asp Ile Pro 
                165                 170                 175     


Lys Arg Lys Asn Arg Thr Arg Gly Arg Ala Arg Gly Ser Ala Gly Gly 
            180                 185                 190         


Arg Arg Arg His Asp Ala Ala Ser Gln Glu Asp His Asp Lys Pro Tyr 
        195                 200                 205             


Val Cys Asp Ile Cys Gly Lys Arg Tyr Lys Asn Arg Pro Gly Leu Ser 
    210                 215                 220                 


Tyr His Tyr Ala His Thr His Leu Ala Ser Glu Glu Gly Asp Glu Ala 
225                 230                 235                 240 


Gln Asp Gln Glu Thr Arg Ser Pro Pro Asn His Arg Asn Glu Asn His 
                245                 250                 255     


Arg Pro Gln Lys Gly Pro Asp Gly Thr Val Ile Pro Asn Asn Tyr Cys 
            260                 265                 270         


Asp Phe Cys Leu Gly Gly Ser Asn Met Asn Lys Lys Ser Gly Arg Pro 
        275                 280                 285             


Glu Glu Leu Val Ser Cys Ala Asp Cys Gly Arg Ser Ala His Leu Gly 
    290                 295                 300                 


Gly Glu Gly Arg Lys Glu Lys Glu Ala Ala Ala Ala Ala Arg Thr Thr 
305                 310                 315                 320 


Glu Asp Leu Phe Gly Ser Thr Ser Glu Ser Asp Thr Ser Thr Phe His 
                325                 330                 335     


Gly Phe Asp Glu Asp Asp Leu Glu Glu Pro Arg Ser Cys Arg Gly Arg 
            340                 345                 350         


Arg Ser Gly Arg Gly Ser Pro Thr Ala Asp Lys Lys Gly Ser Cys 
        355                 360                 365         


<210> 131
<211> 4520
<212> DNA
<213> Homo sapiens

<400> 131
attctcgtct tcacccctgg ccactcctgg agttgaaaac caggttcgct cccggggacg       60

gtagggggtt cctaacgcaa aggaatgcac agggagaatc ggacgtgttt gcgccagctc      120

gtcgcccatc agaaataggg aaaggggtag gaaggcccca ggtttcaaat atatttatat      180

gaaagctgcc gttaagagga cgttggaagc tgaggctgat cagataggag ctcctggctt      240

cagttctggc tcggaagctc ggatacactg cgcttgaacg ccacagcgtt tcacccaaga      300

aagaaaatgt tttatggcag aataaatggg cgtaacttcg ccgcatcctc gctgccggtt      360

gctttcgctg caacaccgct gatgctgttt ctaccgaacc cacaactgat tttcagtttc      420

cccatttcca gccgaaatca cataaccggg ctgatgccac ctggtaaact caagttagag      480

aacctatttc acatgtgcac caggctcggg gaccagttct acaaggaagc cattgagcac      540

tgccggagtt acaactcacg gctgtgtgca gagcgcagcg tgcgtcttcc cttcctggac      600

tcacagactg gggtggccca gaacaactgc tacatctgga tggagaagag gcaccgaggc      660

ccaggccttg ccccgggcca gctgtataca taccctgccc gctgctggcg caagaagaga      720

cgattgcacc cacctgaaga tccaaaactg cggctgctgg agataaaacc tgaagtggag      780

cttcccctga agaaggatgg gttcacctca gagagcacca cgctggaagc cttgctccgt      840

ggcgaggggg ttgagaagaa ggtggatgcc agggaggagg aaagcatcca ggaaatacag      900

agggttttgg aaaatgatga aaatgtagaa gaagggaatg aagaagagga tttggaagag      960

gatattccca agcgaaagaa caggactaga ggacgggctc gcggctctgc agggggcagg     1020

aggaggcacg acgccgcctc tcaggaagac cacgacaaac cttacgtctg tgacatctgt     1080

ggcaagcgct acaagaaccg accggggctc agctaccact atgctcacac tcacctggcc     1140

agcgaggagg gggatgaagc tcaagaccag gagactcggt ccccacccaa ccacagaaat     1200

gagaaccaca ggccccagaa aggaccggat ggaacagtca ttcccaataa ctactgtgac     1260

ttctgcttgg ggggctccaa catgaacaag aagagtgggc ggcctgaaga gctggtgtcc     1320

tgcgcagact gtggacgctc tgctcatttg ggaggagaag gcaggaagga gaaggaggca     1380

gcggccgcag cacgtaccac ggaggactta ttcggttcca cgtcagaaag tgacacgtca     1440

actttccacg gctttgatga ggacgatttg gaagagcctc gctcctgtcg aggacgccgc     1500

agtggccggg gttcgcccac agcagataaa aagggcagtt gctaaaccca cggaacagac     1560

tctctgggca attagccatc cccctctgac tttggtcatt gtgctggttc tgatatatat     1620

tttttttaat gaaaggcaac tttagatttt ccctctatcc ttgctttttt tcccttcacc     1680

tcccacgtgt ccctccatcc ctccccccac ccctctgttt tgggtatgta caacagaagc     1740

acaaactact gaaacaaaac aaaacagcag aatgagcgtt cttccgagag atggcatcgt     1800

gatgcgctat ttattttcca tagaaatagg aagttagacg gattgtctct tttctgaggg     1860

gagggggtct ttttgacagg agcagagttg atgtcctcaa ttttcatatt tattggcaaa     1920

aggaagagaa gaggaacttt gggttggaaa caaagaacca ataacattaa aacattatta     1980

tttatatatt ctagctgtta ttagaatcag actttttttg cgagagagag agagagagag     2040

agagaaggga aatcaaagaa atcgaagcaa tatcctgttt agaggcaagc cgcccggtgg     2100

ggagaatttc ctcaatggga gacggttgca ctattctgtg ccccacggag tttgcggctc     2160

cccgcggcag acccctccct cattctcctc cctgaccttt ccatcttcct ctctgcttgc     2220

gagaaaatgt cagtagttcc agagaagtcg gggtgcctat gcctggcctc cctccacacc     2280

tgggccctga ccagccgcct cctgggctcc tcctcctccg tcagtagagc tgctgttttg     2340

ttattgctgg tttttcctca ctttcctcct ggcaaagaac gacttccaaa tgcagggatg     2400

gaatataagc agaacgtcat gggctcagca gtgactccac cacccgaggc cgaggccgtg     2460

cttctggaag atagaaggag acatcatcgt gtgtttcccc tccccttgcc cctgttaaga     2520

aacgtatcaa tacccattgg atgatcaagg ctaccgtatt tcttctattt ttttttatag     2580

tgcctgccag gcactttgtt ttatgtttcc aatagcactt cctgaaataa accaaagcaa     2640

cactgctcaa ggcccctggg gcgatggaga aggccaccca cctcactgac agtcccaaga     2700

atgaccggct gcgaggtcct agtcaaaagt caacattatg acctggggac tccagcatcc     2760

ttcaagcaag ccatttccga agaaggtgaa aagaagccag gatgattggc acctcctcct     2820

cctcctcctc ttcttcctct tcccttgccc agccccctcc tgtgcgtgtg tttcagacaa     2880

cacaggagcc agcacaggag tggaaaatcc tgcagcgcaa ctcagctcag cccacagaag     2940

ccttgggaat ggcctcagtt tgtgcaataa gaagattttt tttttctttt taaatcttca     3000

ttatattttc tttgattgtc tgtgagaaag tacccaggtc cgcctggaat tactctacag     3060

tagaaataac tgaacacaaa caaactgatg gaaaaaaaga gttaactatt ttatttattt     3120

caatatttaa aaggaaaaaa gtgctgacat ggcacagtat ttttgtttaa agtacctcct     3180

acttcaaaag ttaagcgcaa ttttgtgaag acatgaaatc ataagagtac ttaatgtaaa     3240

ataaaagact gcatattaac tctaaagaaa aatgccccac attttaaata agaaaataaa     3300

gatcaactct gctctctcag gctttttaaa aagccattca tgtatgtgct ttaggtattt     3360

ttatttctgc gagttggatg tggtaagtga ggagtgctca gttttttttt cctccttcaa     3420

aagtctattg aaagtgttgg tgatgttaaa tgattgtgtg ttaagatttg actgaaataa     3480

cttagccaca aatcagcagt ttcccccacc ctcattgccc cctcacccca ggcaagcccc     3540

ttttatctga atgtcagaag cagcctgcct cctagttatc atgtctgatg aggtctagct     3600

caggaaggaa ttccatctat tgatggaata tatcccctca agttcaatag attcgaacac     3660

agagagcttt gtttaaaata atgcagcaaa aaaaaaaaaa aaaaaaaagc aaaaataaaa     3720

gcatcagctg aggtgatatt agttcagtca cctaacaact cctagaagag atgaggaaag     3780

ggaaccttct gctgagctgg cttctggggc ctgagcttcc agagctgtcc ccaagggcta     3840

ggaaggccga cctgaaggat gagaacctca aattcagttg ctggtgggag ccaaggaaga     3900

cggcgggtgt tctaacatgg ccctttctgg ctgagctggc ggaagtgggc gttttggccg     3960

atgggatgta tctcggcgct gtgtctgtgg cccagcaaag gtgcagggct gactggctga     4020

gccactgggt tctacccgca ggctccccac tgcactgggc tttcacacag ccatgctctt     4080

gggtttccct cccttgtaag cagagtcata ataacacacg aatagtctaa ggctgggtat     4140

tctggtcagc agaggtcctt gagtcacagt gttactgaaa tggttctgag cctgagaatc     4200

tctttggcct ctgaaagggc agggcaggtg ggcaccgact tcctgccagt cctttcaggt     4260

ttcctgttca aagccagtcc tgttggtgga ggggatcacc gagagtgtct gtatcatttt     4320

gtagcccttt tctctgacgt tttctggtag aaaatgtccc ttgtcaaaat gctaataatt     4380

atcataataa tctgctttcc aaccaactcc cacaagtgac aacctgtgta gaactgtgat     4440

aaaggtttgc ataatgtagg gtttgtacca agtgtgtgta agtttctgtt aaataaaaag     4500

tctgtttcca atgctcctat                                                 4520


<210> 132
<211> 412
<212> PRT
<213> Homo sapiens

<400> 132
Met Phe Tyr Gly Arg Ile Asn Gly Arg Asn Phe Ala Ala Ser Ser Leu 
1               5                   10                  15      


Pro Val Ala Phe Ala Ala Thr Pro Leu Met Leu Phe Leu Pro Asn Pro 
            20                  25                  30          


Gln Leu Ile Phe Ser Phe Pro Ile Ser Ser Arg Asn His Ile Thr Gly 
        35                  40                  45              


Leu Met Pro Pro Gly Lys Leu Lys Leu Glu Asn Leu Phe His Met Cys 
    50                  55                  60                  


Thr Arg Leu Gly Asp Gln Phe Tyr Lys Glu Ala Ile Glu His Cys Arg 
65                  70                  75                  80  


Ser Tyr Asn Ser Arg Leu Cys Ala Glu Arg Ser Val Arg Leu Pro Phe 
                85                  90                  95      


Leu Asp Ser Gln Thr Gly Val Ala Gln Asn Asn Cys Tyr Ile Trp Met 
            100                 105                 110         


Glu Lys Arg His Arg Gly Pro Gly Leu Ala Pro Gly Gln Leu Tyr Thr 
        115                 120                 125             


Tyr Pro Ala Arg Cys Trp Arg Lys Lys Arg Arg Leu His Pro Pro Glu 
    130                 135                 140                 


Asp Pro Lys Leu Arg Leu Leu Glu Ile Lys Pro Glu Val Glu Leu Pro 
145                 150                 155                 160 


Leu Lys Lys Asp Gly Phe Thr Ser Glu Ser Thr Thr Leu Glu Ala Leu 
                165                 170                 175     


Leu Arg Gly Glu Gly Val Glu Lys Lys Val Asp Ala Arg Glu Glu Glu 
            180                 185                 190         


Ser Ile Gln Glu Ile Gln Arg Val Leu Glu Asn Asp Glu Asn Val Glu 
        195                 200                 205             


Glu Gly Asn Glu Glu Glu Asp Leu Glu Glu Asp Ile Pro Lys Arg Lys 
    210                 215                 220                 


Asn Arg Thr Arg Gly Arg Ala Arg Gly Ser Ala Gly Gly Arg Arg Arg 
225                 230                 235                 240 


His Asp Ala Ala Ser Gln Glu Asp His Asp Lys Pro Tyr Val Cys Asp 
                245                 250                 255     


Ile Cys Gly Lys Arg Tyr Lys Asn Arg Pro Gly Leu Ser Tyr His Tyr 
            260                 265                 270         


Ala His Thr His Leu Ala Ser Glu Glu Gly Asp Glu Ala Gln Asp Gln 
        275                 280                 285             


Glu Thr Arg Ser Pro Pro Asn His Arg Asn Glu Asn His Arg Pro Gln 
    290                 295                 300                 


Lys Gly Pro Asp Gly Thr Val Ile Pro Asn Asn Tyr Cys Asp Phe Cys 
305                 310                 315                 320 


Leu Gly Gly Ser Asn Met Asn Lys Lys Ser Gly Arg Pro Glu Glu Leu 
                325                 330                 335     


Val Ser Cys Ala Asp Cys Gly Arg Ser Ala His Leu Gly Gly Glu Gly 
            340                 345                 350         


Arg Lys Glu Lys Glu Ala Ala Ala Ala Ala Arg Thr Thr Glu Asp Leu 
        355                 360                 365             


Phe Gly Ser Thr Ser Glu Ser Asp Thr Ser Thr Phe His Gly Phe Asp 
    370                 375                 380                 


Glu Asp Asp Leu Glu Glu Pro Arg Ser Cys Arg Gly Arg Arg Ser Gly 
385                 390                 395                 400 


Arg Gly Ser Pro Thr Ala Asp Lys Lys Gly Ser Cys 
                405                 410         


<210> 133
<211> 3155
<212> DNA
<213> Mus musculus

<400> 133
agacaatatt ctgttacatt gtagcaaaat ggcgactgtc attcacaacc ccctgaaagc       60

gcttggggac cagttctaca aggaagccat tgagcactgc cggagctaca actcgaggct      120

gtgcgcagag cggagcgtgc gtctcccctt cctggactcg cagactgggg tggctcagaa      180

caactgctac atctggatgg agaagaggca ccgcggccca ggcctcgctc cgggccagtt      240

gtacacatac cctgcccgct gctggcgcaa gaagcgacga ttgcacccac cagaggaccc      300

aaaactacga ctcctggaaa tcaaacccga agtagaactg cccctgaaga aagatggatt      360

tacctctgag agtaccacac tggaagcctt gcttcgcggc gagggagtag agaagaaggt      420

ggatgccaga gaagaggaaa gcatccagga gatacagagg gttttggaaa atgatgaaaa      480

cgtagaagaa gggaatgaag aggaggattt ggaagaagat gttcccaagc gcaagaacag      540

gaccagagga cgggctcgcg gctctgcagg cggaaggagg aggcatgatg ccgcctctca      600

ggaagaccac gacaaaccct acgtctgcga catctgtggc aagcgctaca agaaccggcc      660

aggactcagc taccactacg ctcatactca cctggccagc gaggagggag acgaagccca      720

agaccaggag acccgatccc cacccaacca cagaaatgag aaccacagac cccagaaagg      780

accagacggg acagtcattc ctaataacta ctgtgacttc tgcttggggg gctccaacat      840

gaacaagaag agtgggaggc ctgaagagct ggtgtcctgt gcagactgtg gacgctctgg      900

tcatccaact tgcctgcagt tcactctgaa catgactgag gcagttaaga cctacaagtg      960

gcagtgcata gagtgtaaat cctgtatcct gtgtgggacc tcggagaacg acgaccagct     1020

actcttctgt gatgactgcg atcgtggcta tcacatgtac tgtttaaatc ccccagtggc     1080

tgagccccca gaaggaagct ggagctgcca tttatgctgg gagctgctca aagagaaagc     1140

atcagccttt ggctgccagg cctagggctc cacccaggtc acagagtgca gcccaccact     1200

agagaggctg aactgaagcc ctgttcaacc cagatggagg tctcctcctg tatatgcaca     1260

cagaccaact acaaggaaaa cgaatagtta cagaagggaa cggagggagc aaggtctcca     1320

ctcacttctc gccctaccca tgacctccca ccccacacat ccttcagcca gctcttcctc     1380

atttctacca gcgggaactt ggcacttttg aagaataatc cagccccggc tctgtggaaa     1440

cttcctcatg ttcactgtca caggcatctc tctttgttgc ttcttgtttt ggaggaagcc     1500

attttgtgac tgctcatcaa ccactcgtgt gttgcttggt ggggttcttg ttttgttgtc     1560

tattgtgttt caagaacttg tcacagagtg tcctcaccct tagcttaggc tcttcatcct     1620

gaaactcaca gaggaacaaa atgccgtggt ggggaagctc ctgcctatta cgagtctcac     1680

tggaagcatc catgtttgga ggccatcttg aagacagaac ttggaaaatg tcttggtttt     1740

cttagtctct gctgagaaga gaagttgtag catttgagcc ttggcagtag catccccagc     1800

tgcgatgacc ttgatccact gcactgccat ttgatcaggg gttcagaggg cctgggagat     1860

gggaggaaca cttggggccc tgctatagcc agccagtatt tgctgttcct caggagggac     1920

taggtggttc cttgaccttc agaactgtgg tgtccttgag gtgagacaac acagtctcta     1980

aacacagaaa agtgctgaag atcctgcccc caaccgaatt gaccgtgaag gtctggctca     2040

gtctctgggg ggtgggactc aagctctgga gaggtgggca aaggatgccc attcaacagt     2100

ccagggttgg ttagaagaga ctgtatgtag ctttgagaaa ctctcccagt attgatgcta     2160

cactatggat ttcttttctg ggcaatttct tccttccatg tagtatatgt ttgccaatga     2220

ccactgagat gtgactggaa attttagaat ggtgaagaga tgaacattac ttaaccagat     2280

cattgggcac agtgattact tgtgactggg tggcaatgat tcagagccct tgtccgttct     2340

tgcaccctaa gctcccccat atggaatggg ctctcgtttg aagcaaggtt tctagaagat     2400

gtaggaaggt ctagattctg agaactcttg tgtgtcagaa gagaagcctt gagggctgga     2460

gtgggctggg ctgcctttga cgcacggcac cagcatgata actgacacat ttctggaaaa     2520

atcgtttgcc caaagggcag gtctccgtga gcaggaccct cgcgcatgct cggcttccct     2580

ggattcagct ccatcgctgt ggtccagcag cttgcaacaa aggcctgggt tatttttagt     2640

cgtcagctcc tgaagaagcc cctggagacc tgggctggct gggcccctct gcccagcggc     2700

agcatggcct ctgccactcc acaggagtca tcctccccct ggctaattgc tcttggcacg     2760

tggacccagg gcagcctggc atggaaccaa gcagtgtgac cccccctgca acttctttgc     2820

agagtgacct gtggcaagag agtgggggtc actttcctgc aggccctgtg gcctcagagc     2880

tagttccatg catacgaaat gatctcattt aaagggcccc tgtccagaga gcatctgtct     2940

cctcctctca agctctcttc ttcctcctgc tggttgctgt gcctgtgtgg attcaaaaga     3000

cccaagggag ggctggagga atggcccgtc tccacggagg ggtacattcc ctctccagac     3060

tctgcgggct ctctcgttcc acaaaaccca aagcagagta tcttcagaga ctaactactt     3120

gtttggggga tcatattaaa ttaatttcag aaggg                                3155


<210> 134
<211> 378
<212> PRT
<213> Mus musculus

<400> 134
Met Ala Thr Val Ile His Asn Pro Leu Lys Ala Leu Gly Asp Gln Phe 
1               5                   10                  15      


Tyr Lys Glu Ala Ile Glu His Cys Arg Ser Tyr Asn Ser Arg Leu Cys 
            20                  25                  30          


Ala Glu Arg Ser Val Arg Leu Pro Phe Leu Asp Ser Gln Thr Gly Val 
        35                  40                  45              


Ala Gln Asn Asn Cys Tyr Ile Trp Met Glu Lys Arg His Arg Gly Pro 
    50                  55                  60                  


Gly Leu Ala Pro Gly Gln Leu Tyr Thr Tyr Pro Ala Arg Cys Trp Arg 
65                  70                  75                  80  


Lys Lys Arg Arg Leu His Pro Pro Glu Asp Pro Lys Leu Arg Leu Leu 
                85                  90                  95      


Glu Ile Lys Pro Glu Val Glu Leu Pro Leu Lys Lys Asp Gly Phe Thr 
            100                 105                 110         


Ser Glu Ser Thr Thr Leu Glu Ala Leu Leu Arg Gly Glu Gly Val Glu 
        115                 120                 125             


Lys Lys Val Asp Ala Arg Glu Glu Glu Ser Ile Gln Glu Ile Gln Arg 
    130                 135                 140                 


Val Leu Glu Asn Asp Glu Asn Val Glu Glu Gly Asn Glu Glu Glu Asp 
145                 150                 155                 160 


Leu Glu Glu Asp Val Pro Lys Arg Lys Asn Arg Thr Arg Gly Arg Ala 
                165                 170                 175     


Arg Gly Ser Ala Gly Gly Arg Arg Arg His Asp Ala Ala Ser Gln Glu 
            180                 185                 190         


Asp His Asp Lys Pro Tyr Val Cys Asp Ile Cys Gly Lys Arg Tyr Lys 
        195                 200                 205             


Asn Arg Pro Gly Leu Ser Tyr His Tyr Ala His Thr His Leu Ala Ser 
    210                 215                 220                 


Glu Glu Gly Asp Glu Ala Gln Asp Gln Glu Thr Arg Ser Pro Pro Asn 
225                 230                 235                 240 


His Arg Asn Glu Asn His Arg Pro Gln Lys Gly Pro Asp Gly Thr Val 
                245                 250                 255     


Ile Pro Asn Asn Tyr Cys Asp Phe Cys Leu Gly Gly Ser Asn Met Asn 
            260                 265                 270         


Lys Lys Ser Gly Arg Pro Glu Glu Leu Val Ser Cys Ala Asp Cys Gly 
        275                 280                 285             


Arg Ser Gly His Pro Thr Cys Leu Gln Phe Thr Leu Asn Met Thr Glu 
    290                 295                 300                 


Ala Val Lys Thr Tyr Lys Trp Gln Cys Ile Glu Cys Lys Ser Cys Ile 
305                 310                 315                 320 


Leu Cys Gly Thr Ser Glu Asn Asp Asp Gln Leu Leu Phe Cys Asp Asp 
                325                 330                 335     


Cys Asp Arg Gly Tyr His Met Tyr Cys Leu Asn Pro Pro Val Ala Glu 
            340                 345                 350         


Pro Pro Glu Gly Ser Trp Ser Cys His Leu Cys Trp Glu Leu Leu Lys 
        355                 360                 365             


Glu Lys Ala Ser Ala Phe Gly Cys Gln Ala 
    370                 375             


<210> 135
<211> 1532
<212> DNA
<213> Mus musculus

<400> 135
agacaatatt ctgttacatt gtagcaaaat ggcgactgtc attcacaacc ccctgaaagc       60

gcttggggac cagttctaca aggaagccat tgagcactgc cggagctaca actcgaggct      120

gtgcgcagag cggagcgtgc gtctcccctt cctggactcg cagactgggg tggctcagaa      180

caactgctac atctggatgg agaagaggca ccgcggccca ggcctcgctc cgggccagtt      240

gtacacatac cctgcccgct gctggcgcaa gaagcgacga ttgcacccac cagaggaccc      300

aaaactacga ctcctggaaa tcaaacccga agtagaactg cccctgaaga aagatggatt      360

tacctctgag agtaccacac tggaagcctt gcttcgcggc gagggagtag agaagaaggt      420

ggatgccaga gaagaggaaa gcatccagga gatacagagg gttttggaaa atgatgaaaa      480

cgtagaagaa gggaatgaag aggaggattt ggaagaagat gttcccaagc gcaagaacag      540

gaccagagga cgggctcgcg gctctgcagg cggaaggagg aggcatgatg ccgcctctca      600

ggaagaccac gacaaaccct acgtctgcga catctgtggc aagcgctaca agaaccggcc      660

aggactcagc taccactacg ctcatactca cctggccagc gaggagggag acgaagccca      720

agaccaggag acccgatccc cacccaacca cagaaatgag aaccacagac cccagaaagg      780

accagacggg acagtcattc ctaataacta ctgtgacttc tgcttggggg gctccaacat      840

gaacaagaag agtgggaggc ctgaagagct ggtgtcctgt gcagactgtg gacgctctgc      900

tcatttggga ggagaaggca ggaaggagaa ggaggcagcg gccgcagcac gtaccacgga      960

ggacttattc ggttccacgt cagaaagtga cacctcaact ttctacggct ttgatgagga     1020

cgatttggaa gagcctcgct cctgtcgagg acgccgcagt ggccggggtt cacccacagc     1080

agataaaaag ggcagctgct gagcacatgg gacagactgt gtggccaatt agccacccct     1140

ccccctgact ctggtcattg ttctagttct gatatatatt tttaaatgaa agacaacttg     1200

ggcatttccc ttaatccttg ccttttcctt ctgcctccca cgtgtccctc cctctcctag     1260

cttccttcta ttttgggtac aacagaagca cacactactg agaaccaggg aagagcagga     1320

tgagagtcct ctggggagcc atggcatcat ggcgggctct tatggactct tatccctaga     1380

agtaggagaa attaagagga ttttctgtca ctgggggagg gcatcttttt gatgtgagca     1440

gagttgattt cctgttttca agagaagagg aacatgaggt ttgaaaacaa ataacattaa     1500

caatatttat ttataaaaaa aaaaaaaaaa aa                                   1532


<210> 136
<211> 357
<212> PRT
<213> Mus musculus

<400> 136
Met Ala Thr Val Ile His Asn Pro Leu Lys Ala Leu Gly Asp Gln Phe 
1               5                   10                  15      


Tyr Lys Glu Ala Ile Glu His Cys Arg Ser Tyr Asn Ser Arg Leu Cys 
            20                  25                  30          


Ala Glu Arg Ser Val Arg Leu Pro Phe Leu Asp Ser Gln Thr Gly Val 
        35                  40                  45              


Ala Gln Asn Asn Cys Tyr Ile Trp Met Glu Lys Arg His Arg Gly Pro 
    50                  55                  60                  


Gly Leu Ala Pro Gly Gln Leu Tyr Thr Tyr Pro Ala Arg Cys Trp Arg 
65                  70                  75                  80  


Lys Lys Arg Arg Leu His Pro Pro Glu Asp Pro Lys Leu Arg Leu Leu 
                85                  90                  95      


Glu Ile Lys Pro Glu Val Glu Leu Pro Leu Lys Lys Asp Gly Phe Thr 
            100                 105                 110         


Ser Glu Ser Thr Thr Leu Glu Ala Leu Leu Arg Gly Glu Gly Val Glu 
        115                 120                 125             


Lys Lys Val Asp Ala Arg Glu Glu Glu Ser Ile Gln Glu Ile Gln Arg 
    130                 135                 140                 


Val Leu Glu Asn Asp Glu Asn Val Glu Glu Gly Asn Glu Glu Glu Asp 
145                 150                 155                 160 


Leu Glu Glu Asp Val Pro Lys Arg Lys Asn Arg Thr Arg Gly Arg Ala 
                165                 170                 175     


Arg Gly Ser Ala Gly Gly Arg Arg Arg His Asp Ala Ala Ser Gln Glu 
            180                 185                 190         


Asp His Asp Lys Pro Tyr Val Cys Asp Ile Cys Gly Lys Arg Tyr Lys 
        195                 200                 205             


Asn Arg Pro Gly Leu Ser Tyr His Tyr Ala His Thr His Leu Ala Ser 
    210                 215                 220                 


Glu Glu Gly Asp Glu Ala Gln Asp Gln Glu Thr Arg Ser Pro Pro Asn 
225                 230                 235                 240 


His Arg Asn Glu Asn His Arg Pro Gln Lys Gly Pro Asp Gly Thr Val 
                245                 250                 255     


Ile Pro Asn Asn Tyr Cys Asp Phe Cys Leu Gly Gly Ser Asn Met Asn 
            260                 265                 270         


Lys Lys Ser Gly Arg Pro Glu Glu Leu Val Ser Cys Ala Asp Cys Gly 
        275                 280                 285             


Arg Ser Ala His Leu Gly Gly Glu Gly Arg Lys Glu Lys Glu Ala Ala 
    290                 295                 300                 


Ala Ala Ala Arg Thr Thr Glu Asp Leu Phe Gly Ser Thr Ser Glu Ser 
305                 310                 315                 320 


Asp Thr Ser Thr Phe Tyr Gly Phe Asp Glu Asp Asp Leu Glu Glu Pro 
                325                 330                 335     


Arg Ser Cys Arg Gly Arg Arg Ser Gly Arg Gly Ser Pro Thr Ala Asp 
            340                 345                 350         


Lys Lys Gly Ser Cys 
        355         


<210> 137
<211> 1529
<212> DNA
<213> Mus musculus

<400> 137
agacaatatt ctgttacatt gtagcaaaat ggcgactgtc attcacaacc ccctgaaagc       60

gcttggggac cagttctaca aggaagccat tgagcactgc cggagctaca actcgaggct      120

gtgcgcagag cggagcgtgc gtctcccctt cctggactcg cagactgggg tggctcagaa      180

caactgctac atctggatgg agaagaggca ccgcggccca ggcctcgctc cgggccagtt      240

gtacacatac cctgcccgct gctggcgcaa gaagcgacga ttgcacccac cagaggaccc      300

aaaactacga ctcctggaaa tcaaacccgt agaactgccc ctgaagaaag atggatttac      360

ctctgagagt accacactgg aagccttgct tcgcggcgag ggagtagaga agaaggtgga      420

tgccagagaa gaggaaagca tccaggagat acagagggtt ttggaaaatg atgaaaacgt      480

agaagaaggg aatgaagagg aggatttgga agaagatgtt cccaagcgca agaacaggac      540

cagaggacgg gctcgcggct ctgcaggcgg aaggaggagg catgatgccg cctctcagga      600

agaccacgac aaaccctacg tctgcgacat ctgtggcaag cgctacaaga accggccagg      660

actcagctac cactacgctc atactcacct ggccagcgag gagggagacg aagcccaaga      720

ccaggagacc cgatccccac ccaaccacag aaatgagaac cacagacccc agaaaggacc      780

agacgggaca gtcattccta ataactactg tgacttctgc ttggggggct ccaacatgaa      840

caagaagagt gggaggcctg aagagctggt gtcctgtgca gactgtggac gctctgctca      900

tttgggagga gaaggcagga aggagaagga ggcagcggcc gcagcacgta ccacggagga      960

cttattcggt tccacgtcag aaagtgacac ctcaactttc tacggctttg atgaggacga     1020

tttggaagag cctcgctcct gtcgaggacg ccgcagtggc cggggttcac ccacagcaga     1080

taaaaagggc agctgctgag cacatgggac agactgtgtg gccaattagc cacccctccc     1140

cctgactctg gtcattgttc tagttctgat atatattttt aaatgaaaga caacttgggc     1200

atttccctta atccttgcct tttccttctg cctcccacgt gtccctccct ctcctagctt     1260

ccttctattt tgggtacaac agaagcacac actactgaga accagggaag agcaggatga     1320

gagtcctctg gggagccatg gcatcatggc gggctcttat ggactcttat ccctagaagt     1380

aggagaaatt aagaggattt tctgtcactg ggggagggca tctttttgat gtgagcagag     1440

ttgatttcct gttttcaaga gaagaggaac atgaggtttg aaaacaaata acattaacaa     1500

tatttattta taaaaaaaaa aaaaaaaaa                                       1529


<210> 138
<211> 356
<212> PRT
<213> Mus musculus

<400> 138
Met Ala Thr Val Ile His Asn Pro Leu Lys Ala Leu Gly Asp Gln Phe 
1               5                   10                  15      


Tyr Lys Glu Ala Ile Glu His Cys Arg Ser Tyr Asn Ser Arg Leu Cys 
            20                  25                  30          


Ala Glu Arg Ser Val Arg Leu Pro Phe Leu Asp Ser Gln Thr Gly Val 
        35                  40                  45              


Ala Gln Asn Asn Cys Tyr Ile Trp Met Glu Lys Arg His Arg Gly Pro 
    50                  55                  60                  


Gly Leu Ala Pro Gly Gln Leu Tyr Thr Tyr Pro Ala Arg Cys Trp Arg 
65                  70                  75                  80  


Lys Lys Arg Arg Leu His Pro Pro Glu Asp Pro Lys Leu Arg Leu Leu 
                85                  90                  95      


Glu Ile Lys Pro Val Glu Leu Pro Leu Lys Lys Asp Gly Phe Thr Ser 
            100                 105                 110         


Glu Ser Thr Thr Leu Glu Ala Leu Leu Arg Gly Glu Gly Val Glu Lys 
        115                 120                 125             


Lys Val Asp Ala Arg Glu Glu Glu Ser Ile Gln Glu Ile Gln Arg Val 
    130                 135                 140                 


Leu Glu Asn Asp Glu Asn Val Glu Glu Gly Asn Glu Glu Glu Asp Leu 
145                 150                 155                 160 


Glu Glu Asp Val Pro Lys Arg Lys Asn Arg Thr Arg Gly Arg Ala Arg 
                165                 170                 175     


Gly Ser Ala Gly Gly Arg Arg Arg His Asp Ala Ala Ser Gln Glu Asp 
            180                 185                 190         


His Asp Lys Pro Tyr Val Cys Asp Ile Cys Gly Lys Arg Tyr Lys Asn 
        195                 200                 205             


Arg Pro Gly Leu Ser Tyr His Tyr Ala His Thr His Leu Ala Ser Glu 
    210                 215                 220                 


Glu Gly Asp Glu Ala Gln Asp Gln Glu Thr Arg Ser Pro Pro Asn His 
225                 230                 235                 240 


Arg Asn Glu Asn His Arg Pro Gln Lys Gly Pro Asp Gly Thr Val Ile 
                245                 250                 255     


Pro Asn Asn Tyr Cys Asp Phe Cys Leu Gly Gly Ser Asn Met Asn Lys 
            260                 265                 270         


Lys Ser Gly Arg Pro Glu Glu Leu Val Ser Cys Ala Asp Cys Gly Arg 
        275                 280                 285             


Ser Ala His Leu Gly Gly Glu Gly Arg Lys Glu Lys Glu Ala Ala Ala 
    290                 295                 300                 


Ala Ala Arg Thr Thr Glu Asp Leu Phe Gly Ser Thr Ser Glu Ser Asp 
305                 310                 315                 320 


Thr Ser Thr Phe Tyr Gly Phe Asp Glu Asp Asp Leu Glu Glu Pro Arg 
                325                 330                 335     


Ser Cys Arg Gly Arg Arg Ser Gly Arg Gly Ser Pro Thr Ala Asp Lys 
            340                 345                 350         


Lys Gly Ser Cys 
        355     


<210> 139
<211> 1932
<212> DNA
<213> Homo sapiens

<400> 139
agacttaggc ctggacccta gtgattggct gataggagga gccagcaagt gtggctgagc       60

tccggggtgt gtggacgccg ctttgttgcc tgaggtgggt ggcggtggaa gttaagggag      120

tcaggggcta tcgctcctcg agactcgcag tcgcggccac tgcagtcact tcgccagtta      180

gcccttaggg taggagtcgc gccggcagca gccatgagcg gcggcgtgta cgggggagat      240

gaagttggag cccttgtttt tgacattgga tcctatactg tgagagctgg ttatgctggt      300

gaggactgcc ccaaggtgga ttttcctaca gctattggta tggtggtaga aagagatgac      360

ggaagcacat taatggaaat agatggcgat aaaggcaaac aaggcggtcc cacctactac      420

atagatacta atgctctgcg tgttccgagg gagaatatgg aggccatttc acctctaaaa      480

aatgggatgg ttgaagactg ggatagtttc caagctattt tggatcatac ctacaaaatg      540

catgtcaaat cagaagccag tctccatcct gttctcatgt cagaggcacc gtggaatact      600

agagcaaaga gagagaaact gacagagtta atgtttgaac actacaacat ccctgccttc      660

ttcctttgca aaactgcagt tttgacagca tttgctaatg gtcgttctac tgggctgatt      720

ttggacagtg gagccactca taccactgca attccagtcc acgatggcta tgtccttcaa      780

caaggcattg tgaaatcccc tcttgctgga gactttatta ctatgcagtg cagagaactc      840

ttccaagaaa tgaatattga attggttcct ccatatatga ttgcatcaaa agaagctgtt      900

cgtgaaggat ctccagcaaa ctggaaaaga aaagagaagt tgcctcaggt tacgaggtct      960

tggcacaatt atatgtgtaa ttgtgttatc caggattttc aagcttcggt acttcaagtg     1020

tcagattcaa cttatgatga acaagtggct gcacagatgc caactgttca ttatgaattc     1080

cccaatggct acaattgtga ttttggtgca gagcggctaa agattccaga aggattattt     1140

gacccttcca atgtaaaggg gttatcagga aacacaatgt taggagtcag tcatgttgtc     1200

accacaagtg ttgggatgtg tgatattgac atcagaccag gtctctatgg cagtgtaata     1260

gtggcaggag gaaacacact aatacagagt tttactgaca ggttgaatag agagctgtct     1320

cagaaaactc ctccaagtat gcggttgaaa ttgattgcaa ataatacaac agtggaacgg     1380

aggtttagct catggattgg cggctccatt ctagcctctt tgggtacctt tcaacagatg     1440

tggatttcca agcaagaata tgaagaagga gggaagcagt gtgtagaaag aaaatgccct     1500

tgagaaagag ttcccaagct tctaccttcc ttttgtcacc ttacgtttca tagctttagt     1560

atactcagga aaagaatgac catcttttgt agaatgttta tacatttttg catatttcaa     1620

tttccactta aattttttaa agctttaact ggctctataa attaagtttg tgctttcctt     1680

gaaatgcact tattcttatt acaagcattt tataattttg tataaatgtc tattttctct     1740

aaatattttg ctttcagtaa aatgctttcc aactctgttt agtgtattaa ttaccagtgg     1800

attggtagaa ctgcttttta ttgactagta aaagttactg cctatgcttt ttaccttagg     1860

cttacagaat taaataaaaa ttagccattc cagaaataaa aaaaaaaaaa aaaaaaaaaa     1920

aaaaaaaaaa aa                                                         1932


<210> 140
<211> 429
<212> PRT
<213> Homo sapiens

<400> 140
Met Ser Gly Gly Val Tyr Gly Gly Asp Glu Val Gly Ala Leu Val Phe 
1               5                   10                  15      


Asp Ile Gly Ser Tyr Thr Val Arg Ala Gly Tyr Ala Gly Glu Asp Cys 
            20                  25                  30          


Pro Lys Val Asp Phe Pro Thr Ala Ile Gly Met Val Val Glu Arg Asp 
        35                  40                  45              


Asp Gly Ser Thr Leu Met Glu Ile Asp Gly Asp Lys Gly Lys Gln Gly 
    50                  55                  60                  


Gly Pro Thr Tyr Tyr Ile Asp Thr Asn Ala Leu Arg Val Pro Arg Glu 
65                  70                  75                  80  


Asn Met Glu Ala Ile Ser Pro Leu Lys Asn Gly Met Val Glu Asp Trp 
                85                  90                  95      


Asp Ser Phe Gln Ala Ile Leu Asp His Thr Tyr Lys Met His Val Lys 
            100                 105                 110         


Ser Glu Ala Ser Leu His Pro Val Leu Met Ser Glu Ala Pro Trp Asn 
        115                 120                 125             


Thr Arg Ala Lys Arg Glu Lys Leu Thr Glu Leu Met Phe Glu His Tyr 
    130                 135                 140                 


Asn Ile Pro Ala Phe Phe Leu Cys Lys Thr Ala Val Leu Thr Ala Phe 
145                 150                 155                 160 


Ala Asn Gly Arg Ser Thr Gly Leu Ile Leu Asp Ser Gly Ala Thr His 
                165                 170                 175     


Thr Thr Ala Ile Pro Val His Asp Gly Tyr Val Leu Gln Gln Gly Ile 
            180                 185                 190         


Val Lys Ser Pro Leu Ala Gly Asp Phe Ile Thr Met Gln Cys Arg Glu 
        195                 200                 205             


Leu Phe Gln Glu Met Asn Ile Glu Leu Val Pro Pro Tyr Met Ile Ala 
    210                 215                 220                 


Ser Lys Glu Ala Val Arg Glu Gly Ser Pro Ala Asn Trp Lys Arg Lys 
225                 230                 235                 240 


Glu Lys Leu Pro Gln Val Thr Arg Ser Trp His Asn Tyr Met Cys Asn 
                245                 250                 255     


Cys Val Ile Gln Asp Phe Gln Ala Ser Val Leu Gln Val Ser Asp Ser 
            260                 265                 270         


Thr Tyr Asp Glu Gln Val Ala Ala Gln Met Pro Thr Val His Tyr Glu 
        275                 280                 285             


Phe Pro Asn Gly Tyr Asn Cys Asp Phe Gly Ala Glu Arg Leu Lys Ile 
    290                 295                 300                 


Pro Glu Gly Leu Phe Asp Pro Ser Asn Val Lys Gly Leu Ser Gly Asn 
305                 310                 315                 320 


Thr Met Leu Gly Val Ser His Val Val Thr Thr Ser Val Gly Met Cys 
                325                 330                 335     


Asp Ile Asp Ile Arg Pro Gly Leu Tyr Gly Ser Val Ile Val Ala Gly 
            340                 345                 350         


Gly Asn Thr Leu Ile Gln Ser Phe Thr Asp Arg Leu Asn Arg Glu Leu 
        355                 360                 365             


Ser Gln Lys Thr Pro Pro Ser Met Arg Leu Lys Leu Ile Ala Asn Asn 
    370                 375                 380                 


Thr Thr Val Glu Arg Arg Phe Ser Ser Trp Ile Gly Gly Ser Ile Leu 
385                 390                 395                 400 


Ala Ser Leu Gly Thr Phe Gln Gln Met Trp Ile Ser Lys Gln Glu Tyr 
                405                 410                 415     


Glu Glu Gly Gly Lys Gln Cys Val Glu Arg Lys Cys Pro 
            420                 425                 


<210> 141
<211> 1788
<212> DNA
<213> Homo sapiens

<400> 141
agacttaggc ctggacccta gtgattggct gataggagga gccagcaagt gtggctgagc       60

tccggggtgt gtggacgccg ctttgttgcc tgagatgaag ttggagccct tgtttttgac      120

attggatcct atactgtgag agctggttat gctggtgagg actgccccaa ggtggatttt      180

cctacagcta ttggtatggt ggtagaaaga gatgacggaa gcacattaat ggaaatagat      240

ggcgataaag gcaaacaagg cggtcccacc tactacatag atactaatgc tctgcgtgtt      300

ccgagggaga atatggaggc catttcacct ctaaaaaatg ggatggttga agactgggat      360

agtttccaag ctattttgga tcatacctac aaaatgcatg tcaaatcaga agccagtctc      420

catcctgttc tcatgtcaga ggcaccgtgg aatactagag caaagagaga gaaactgaca      480

gagttaatgt ttgaacacta caacatccct gccttcttcc tttgcaaaac tgcagttttg      540

acagcatttg ctaatggtcg ttctactggg ctgattttgg acagtggagc cactcatacc      600

actgcaattc cagtccacga tggctatgtc cttcaacaag gcattgtgaa atcccctctt      660

gctggagact ttattactat gcagtgcaga gaactcttcc aagaaatgaa tattgaattg      720

gttcctccat atatgattgc atcaaaagaa gctgttcgtg aaggatctcc agcaaactgg      780

aaaagaaaag agaagttgcc tcaggttacg aggtcttggc acaattatat gtgtaattgt      840

gttatccagg attttcaagc ttcggtactt caagtgtcag attcaactta tgatgaacaa      900

gtggctgcac agatgccaac tgttcattat gaattcccca atggctacaa ttgtgatttt      960

ggtgcagagc ggctaaagat tccagaagga ttatttgacc cttccaatgt aaaggggtta     1020

tcaggaaaca caatgttagg agtcagtcat gttgtcacca caagtgttgg gatgtgtgat     1080

attgacatca gaccaggtct ctatggcagt gtaatagtgg caggaggaaa cacactaata     1140

cagagtttta ctgacaggtt gaatagagag ctgtctcaga aaactcctcc aagtatgcgg     1200

ttgaaattga ttgcaaataa tacaacagtg gaacggaggt ttagctcatg gattggcggc     1260

tccattctag cctctttggg tacctttcaa cagatgtgga tttccaagca agaatatgaa     1320

gaaggaggga agcagtgtgt agaaagaaaa tgcccttgag aaagagttcc caagcttcta     1380

ccttcctttt gtcaccttac gtttcatagc tttagtatac tcaggaaaag aatgaccatc     1440

ttttgtagaa tgtttataca tttttgcata tttcaatttc cacttaaatt ttttaaagct     1500

ttaactggct ctataaatta agtttgtgct ttccttgaaa tgcacttatt cttattacaa     1560

gcattttata attttgtata aatgtctatt ttctctaaat attttgcttt cagtaaaatg     1620

ctttccaact ctgtttagtg tattaattac cagtggattg gtagaactgc tttttattga     1680

ctagtaaaag ttactgccta tgctttttac cttaggctta cagaattaaa taaaaattag     1740

ccattccaga aataaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaa                  1788


<210> 142
<211> 1980
<212> DNA
<213> Homo sapiens

<400> 142
agacttaggc ctggacccta gtgattggct gataggagga gccagcaagt gtggctgagc       60

tccggggtgt gtggacgccg ctttgttgcc tgaggtgggt ggcggtggaa gttaagggag      120

tcaggggcta tcgctcctcg agactcgcag tcgcggccac tgcagtcact tcgccagtta      180

gcccttaggg taggagtcgc gccggcagca gccatgagcg gcggcgtgta cgggggaggt      240

gagtgagtgc ggccggacga gagagcgcgc cttttcggcg tgtgggatga agttggagcc      300

cttgtttttg acattggatc ctatactgtg agagctggtt atgctggtga ggactgcccc      360

aaggtggatt ttcctacagc tattggtatg gtggtagaaa gagatgacgg aagcacatta      420

atggaaatag atggcgataa aggcaaacaa ggcggtccca cctactacat agatactaat      480

gctctgcgtg ttccgaggga gaatatggag gccatttcac ctctaaaaaa tgggatggtt      540

gaagactggg atagtttcca agctattttg gatcatacct acaaaatgca tgtcaaatca      600

gaagccagtc tccatcctgt tctcatgtca gaggcaccgt ggaatactag agcaaagaga      660

gagaaactga cagagttaat gtttgaacac tacaacatcc ctgccttctt cctttgcaaa      720

actgcagttt tgacagcatt tgctaatggt cgttctactg ggctgatttt ggacagtgga      780

gccactcata ccactgcaat tccagtccac gatggctatg tccttcaaca aggcattgtg      840

aaatcccctc ttgctggaga ctttattact atgcagtgca gagaactctt ccaagaaatg      900

aatattgaat tggttcctcc atatatgatt gcatcaaaag aagctgttcg tgaaggatct      960

ccagcaaact ggaaaagaaa agagaagttg cctcaggtta cgaggtcttg gcacaattat     1020

atgtgtaatt gtgttatcca ggattttcaa gcttcggtac ttcaagtgtc agattcaact     1080

tatgatgaac aagtggctgc acagatgcca actgttcatt atgaattccc caatggctac     1140

aattgtgatt ttggtgcaga gcggctaaag attccagaag gattatttga cccttccaat     1200

gtaaaggggt tatcaggaaa cacaatgtta ggagtcagtc atgttgtcac cacaagtgtt     1260

gggatgtgtg atattgacat cagaccaggt ctctatggca gtgtaatagt ggcaggagga     1320

aacacactaa tacagagttt tactgacagg ttgaatagag agctgtctca gaaaactcct     1380

ccaagtatgc ggttgaaatt gattgcaaat aatacaacag tggaacggag gtttagctca     1440

tggattggcg gctccattct agcctctttg ggtacctttc aacagatgtg gatttccaag     1500

caagaatatg aagaaggagg gaagcagtgt gtagaaagaa aatgcccttg agaaagagtt     1560

cccaagcttc taccttcctt ttgtcacctt acgtttcata gctttagtat actcaggaaa     1620

agaatgacca tcttttgtag aatgtttata catttttgca tatttcaatt tccacttaaa     1680

ttttttaaag ctttaactgg ctctataaat taagtttgtg ctttccttga aatgcactta     1740

ttcttattac aagcatttta taattttgta taaatgtcta ttttctctaa atattttgct     1800

ttcagtaaaa tgctttccaa ctctgtttag tgtattaatt accagtggat tggtagaact     1860

gctttttatt gactagtaaa agttactgcc tatgcttttt accttaggct tacagaatta     1920

aataaaaatt agccattcca gaaataaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1980


<210> 143
<211> 387
<212> PRT
<213> Homo sapiens

<400> 143
Met Val Val Glu Arg Asp Asp Gly Ser Thr Leu Met Glu Ile Asp Gly 
1               5                   10                  15      


Asp Lys Gly Lys Gln Gly Gly Pro Thr Tyr Tyr Ile Asp Thr Asn Ala 
            20                  25                  30          


Leu Arg Val Pro Arg Glu Asn Met Glu Ala Ile Ser Pro Leu Lys Asn 
        35                  40                  45              


Gly Met Val Glu Asp Trp Asp Ser Phe Gln Ala Ile Leu Asp His Thr 
    50                  55                  60                  


Tyr Lys Met His Val Lys Ser Glu Ala Ser Leu His Pro Val Leu Met 
65                  70                  75                  80  


Ser Glu Ala Pro Trp Asn Thr Arg Ala Lys Arg Glu Lys Leu Thr Glu 
                85                  90                  95      


Leu Met Phe Glu His Tyr Asn Ile Pro Ala Phe Phe Leu Cys Lys Thr 
            100                 105                 110         


Ala Val Leu Thr Ala Phe Ala Asn Gly Arg Ser Thr Gly Leu Ile Leu 
        115                 120                 125             


Asp Ser Gly Ala Thr His Thr Thr Ala Ile Pro Val His Asp Gly Tyr 
    130                 135                 140                 


Val Leu Gln Gln Gly Ile Val Lys Ser Pro Leu Ala Gly Asp Phe Ile 
145                 150                 155                 160 


Thr Met Gln Cys Arg Glu Leu Phe Gln Glu Met Asn Ile Glu Leu Val 
                165                 170                 175     


Pro Pro Tyr Met Ile Ala Ser Lys Glu Ala Val Arg Glu Gly Ser Pro 
            180                 185                 190         


Ala Asn Trp Lys Arg Lys Glu Lys Leu Pro Gln Val Thr Arg Ser Trp 
        195                 200                 205             


His Asn Tyr Met Cys Asn Cys Val Ile Gln Asp Phe Gln Ala Ser Val 
    210                 215                 220                 


Leu Gln Val Ser Asp Ser Thr Tyr Asp Glu Gln Val Ala Ala Gln Met 
225                 230                 235                 240 


Pro Thr Val His Tyr Glu Phe Pro Asn Gly Tyr Asn Cys Asp Phe Gly 
                245                 250                 255     


Ala Glu Arg Leu Lys Ile Pro Glu Gly Leu Phe Asp Pro Ser Asn Val 
            260                 265                 270         


Lys Gly Leu Ser Gly Asn Thr Met Leu Gly Val Ser His Val Val Thr 
        275                 280                 285             


Thr Ser Val Gly Met Cys Asp Ile Asp Ile Arg Pro Gly Leu Tyr Gly 
    290                 295                 300                 


Ser Val Ile Val Ala Gly Gly Asn Thr Leu Ile Gln Ser Phe Thr Asp 
305                 310                 315                 320 


Arg Leu Asn Arg Glu Leu Ser Gln Lys Thr Pro Pro Ser Met Arg Leu 
                325                 330                 335     


Lys Leu Ile Ala Asn Asn Thr Thr Val Glu Arg Arg Phe Ser Ser Trp 
            340                 345                 350         


Ile Gly Gly Ser Ile Leu Ala Ser Leu Gly Thr Phe Gln Gln Met Trp 
        355                 360                 365             


Ile Ser Lys Gln Glu Tyr Glu Glu Gly Gly Lys Gln Cys Val Glu Arg 
    370                 375                 380                 


Lys Cys Pro 
385         


<210> 144
<211> 1969
<212> DNA
<213> Mus musculus

<400> 144
cttcttctgt cgcttctccc tctccctgcc cctacggatg ccttccattg gctaagacgg       60

ctaaaccgcg cggggatgca gcagcgccac actctgattg gctaatgact aagccggacc      120

ctttgtcatt ggttgatacg agaaaccagc aagagtggct gtgcagcggg cgtgcggccg      180

ctgctttgtt gccggagggg gcggcgttgg aagttgcagg cttgcggggc cggcgttctc      240

agggagagga gtcacgccgc tgttatcttt cgtccggtag tcttcggcca gtccccgcca      300

gacagtagcc atgagcggcg gcgtgtacgg cggagatgaa gttggcgctc ttgtttttga      360

cattggatcg tacacagtga gggctggcta tgctggcgag gactgcccta aggttgattt      420

ccccacggct atcggtgtgg tgctggagag agatgacgga agtacaatga tggagattga      480

tggtgacaaa ggcaagcagg gcgggcccac ctactacata gacaccaatg ccctccgcgt      540

gcccagggag aacatggagg ccatctcacc actcaagaat ggcatggttg aagactggga      600

tagtttccag gccattttgg atcatacata caagatgcat gtcaaatccg aagccagcct      660

gcatcctgtt ctcatgtcgg aagcaccgtg gaacaccagg gcgaagagag agaaactgac      720

agagttgatg tttgagcact acagcatccc tgcattcttc ctttgcaaaa ctgcagtttt      780

gacggcattt gctaatggtc gttctactgg gctgattttg gacagtggag ctacccacac      840

cactgcgatt ccagtccacg atggctatgt tcttcaacaa ggcattgtga aatcccctct      900

ggctggagac ttcattacca tgcagtgcag agaactcttc caggaaatga acatagaact      960

cattcctcct tacatgattg catcaaaaga ggctgttcga gaaggttctc cagccaactg     1020

gaaaagaaaa gagaaactgc cccaggttac aaggtcttgg cacaattaca tgtgcaactg     1080

cgtcatccag gattttcaag cttccgttct tcaggtgtca gactccacct acgacgaaca     1140

agtggctgca cagatgccaa ccgtccacta cgaattcccc aatggctaca actgtgattt     1200

tggggcagag cggctgaaaa ttcctgaagg gttatttgac ccttccaacg taaagggact     1260

gtctgggaac acgatgctgg gagtcagtca cgttgtcaca accagcgtcg gaatgtgtga     1320

catcgacatc agaccaggtc tctacggcag tgtgatcgta gcaggaggaa acacgctaat     1380

acagagtttc actgacaggt taaatagaga gctttctcag aaaactccac caagtatgcg     1440

gttgaaactg attgcaaaca acacgacggt ggagcggagg ttcagctcat ggattggtgg     1500

ctctatccta gcatctttgg gtacctttca acagatgtgg atttctaaac aggaatatga     1560

agaaggaggg aagcagtgtg tagaaagaaa atgcccttga gggctccacc ctgcctgccc     1620

gtcacctcaa cgtctgtagc tttagtacac tcaggaaaag atgaccatct tttgtagaat     1680

gtttatacat gtttgcatat ttcaatttcc acttaaattt tttaaggctt taactggctc     1740

tataaattaa atgagtttgt gctttccttg aaatgcactt attcttatta caggcatttt     1800

ataattttgt atgaatgtct attttctcta aatattttgc tttcagtaag tactctccag     1860

ctctcctggg ggttggttgg tggaattact ctgtattgac aagtacaagt tactgcctat     1920

gctttgtacc ttaggctaca aaactaaata aaaatcacta ctgtcctag                 1969


<210> 145
<211> 429
<212> PRT
<213> Mus musculus

<400> 145
Met Ser Gly Gly Val Tyr Gly Gly Asp Glu Val Gly Ala Leu Val Phe 
1               5                   10                  15      


Asp Ile Gly Ser Tyr Thr Val Arg Ala Gly Tyr Ala Gly Glu Asp Cys 
            20                  25                  30          


Pro Lys Val Asp Phe Pro Thr Ala Ile Gly Val Val Leu Glu Arg Asp 
        35                  40                  45              


Asp Gly Ser Thr Met Met Glu Ile Asp Gly Asp Lys Gly Lys Gln Gly 
    50                  55                  60                  


Gly Pro Thr Tyr Tyr Ile Asp Thr Asn Ala Leu Arg Val Pro Arg Glu 
65                  70                  75                  80  


Asn Met Glu Ala Ile Ser Pro Leu Lys Asn Gly Met Val Glu Asp Trp 
                85                  90                  95      


Asp Ser Phe Gln Ala Ile Leu Asp His Thr Tyr Lys Met His Val Lys 
            100                 105                 110         


Ser Glu Ala Ser Leu His Pro Val Leu Met Ser Glu Ala Pro Trp Asn 
        115                 120                 125             


Thr Arg Ala Lys Arg Glu Lys Leu Thr Glu Leu Met Phe Glu His Tyr 
    130                 135                 140                 


Ser Ile Pro Ala Phe Phe Leu Cys Lys Thr Ala Val Leu Thr Ala Phe 
145                 150                 155                 160 


Ala Asn Gly Arg Ser Thr Gly Leu Ile Leu Asp Ser Gly Ala Thr His 
                165                 170                 175     


Thr Thr Ala Ile Pro Val His Asp Gly Tyr Val Leu Gln Gln Gly Ile 
            180                 185                 190         


Val Lys Ser Pro Leu Ala Gly Asp Phe Ile Thr Met Gln Cys Arg Glu 
        195                 200                 205             


Leu Phe Gln Glu Met Asn Ile Glu Leu Ile Pro Pro Tyr Met Ile Ala 
    210                 215                 220                 


Ser Lys Glu Ala Val Arg Glu Gly Ser Pro Ala Asn Trp Lys Arg Lys 
225                 230                 235                 240 


Glu Lys Leu Pro Gln Val Thr Arg Ser Trp His Asn Tyr Met Cys Asn 
                245                 250                 255     


Cys Val Ile Gln Asp Phe Gln Ala Ser Val Leu Gln Val Ser Asp Ser 
            260                 265                 270         


Thr Tyr Asp Glu Gln Val Ala Ala Gln Met Pro Thr Val His Tyr Glu 
        275                 280                 285             


Phe Pro Asn Gly Tyr Asn Cys Asp Phe Gly Ala Glu Arg Leu Lys Ile 
    290                 295                 300                 


Pro Glu Gly Leu Phe Asp Pro Ser Asn Val Lys Gly Leu Ser Gly Asn 
305                 310                 315                 320 


Thr Met Leu Gly Val Ser His Val Val Thr Thr Ser Val Gly Met Cys 
                325                 330                 335     


Asp Ile Asp Ile Arg Pro Gly Leu Tyr Gly Ser Val Ile Val Ala Gly 
            340                 345                 350         


Gly Asn Thr Leu Ile Gln Ser Phe Thr Asp Arg Leu Asn Arg Glu Leu 
        355                 360                 365             


Ser Gln Lys Thr Pro Pro Ser Met Arg Leu Lys Leu Ile Ala Asn Asn 
    370                 375                 380                 


Thr Thr Val Glu Arg Arg Phe Ser Ser Trp Ile Gly Gly Ser Ile Leu 
385                 390                 395                 400 


Ala Ser Leu Gly Thr Phe Gln Gln Met Trp Ile Ser Lys Gln Glu Tyr 
                405                 410                 415     


Glu Glu Gly Gly Lys Gln Cys Val Glu Arg Lys Cys Pro 
            420                 425                 


<210> 146
<211> 1940
<212> DNA
<213> Homo sapiens

<400> 146
gagtgagcgg cgcggggcca atcagcgtgc gccgttccga aagttgcctt ttatggctcg       60

agcggccgcg gcggcgccct ataaaaccca gcggcgcgac gcgccaccac cgccgagacc      120

gcgtccgccc cgcgagcaca gagcctcgcc tttgccgatc cgccgcccgt ccacacccgc      180

cgccagctca ccatggatga tgatatcgcc gcgctcgtcg tcgacaacgg ctccggcatg      240

tgcaaggccg gcttcgcggg cgacgatgcc ccccgggccg tcttcccctc catcgtgggg      300

cgccccaggc accagggcgt gatggtgggc atgggtcaga aggattccta tgtgggcgac      360

gaggcccaga gcaagagagg catcctcacc ctgaagtacc ccatcgagca cggcatcgtc      420

accaactggg acgacatgga gaaaatctgg caccacacct tctacaatga gctgcgtgtg      480

gctcccgagg agcaccccgt gctgctgacc gaggcccccc tgaaccccaa ggccaaccgc      540

gagaagatga cccagatcat gtttgagacc ttcaacaccc cagccatgta cgttgctatc      600

caggctgtgc tatccctgta cgcctctggc cgtaccactg gcatcgtgat ggactccggt      660

gacggggtca cccacactgt gcccatctac gaggggtatg ccctccccca tgccatcctg      720

cgtctggacc tggctggccg ggacctgact gactacctca tgaagatcct caccgagcgc      780

ggctacagct tcaccaccac ggccgagcgg gaaatcgtgc gtgacattaa ggagaagctg      840

tgctacgtcg ccctggactt cgagcaagag atggccacgg ctgcttccag ctcctccctg      900

gagaagagct acgagctgcc tgacggccag gtcatcacca ttggcaatga gcggttccgc      960

tgccctgagg cactcttcca gccttccttc ctgggcatgg agtcctgtgg catccacgaa     1020

actaccttca actccatcat gaagtgtgac gtggacatcc gcaaagacct gtacgccaac     1080

acagtgctgt ctggcggcac caccatgtac cctggcattg ccgacaggat gcagaaggag     1140

atcactgccc tggcacccag cacaatgaag atcaagatca ttgctcctcc tgagcgcaag     1200

tactccgtgt ggatcggcgg ctccatcctg gcctcgctgt ccaccttcca gcagatgtgg     1260

atcagcaagc aggagtatga cgagtccggc ccctccatcg tccaccgcaa atgcttctag     1320

gcggactatg acttagttgc gttacaccct ttcttgacaa aacctaactt gcgcagaaaa     1380

caagatgaga ttggcatggc tttatttgtt ttttttgttt tgttttggtt tttttttttt     1440

ttttggcttg actcaggatt taaaaactgg aacggtgaag gtgacagcag tcggttggag     1500

cgagcatccc ccaaagttca caatgtggcc gaggactttg attgcacatt gttgtttttt     1560

taatagtcat tccaaatatg agatgcgttg ttacaggaag tcccttgcca tcctaaaagc     1620

caccccactt ctctctaagg agaatggccc agtcctctcc caagtccaca caggggaggt     1680

gatagcattg ctttcgtgta aattatgtaa tgcaaaattt ttttaatctt cgccttaata     1740

cttttttatt ttgttttatt ttgaatgatg agccttcgtg cccccccttc cccctttttt     1800

gtcccccaac ttgagatgta tgaaggcttt tggtctccct gggagtgggt ggaggcagcc     1860

agggcttacc tgtacactga cttgagacca gttgaataaa agtgcacacc ttaaaaatga     1920

ggaaaaaaaa aaaaaaaaaa                                                 1940


<210> 147
<211> 375
<212> PRT
<213> Homo sapiens

<400> 147
Met Asp Asp Asp Ile Ala Ala Leu Val Val Asp Asn Gly Ser Gly Met 
1               5                   10                  15      


Cys Lys Ala Gly Phe Ala Gly Asp Asp Ala Pro Arg Ala Val Phe Pro 
            20                  25                  30          


Ser Ile Val Gly Arg Pro Arg His Gln Gly Val Met Val Gly Met Gly 
        35                  40                  45              


Gln Lys Asp Ser Tyr Val Gly Asp Glu Ala Gln Ser Lys Arg Gly Ile 
    50                  55                  60                  


Leu Thr Leu Lys Tyr Pro Ile Glu His Gly Ile Val Thr Asn Trp Asp 
65                  70                  75                  80  


Asp Met Glu Lys Ile Trp His His Thr Phe Tyr Asn Glu Leu Arg Val 
                85                  90                  95      


Ala Pro Glu Glu His Pro Val Leu Leu Thr Glu Ala Pro Leu Asn Pro 
            100                 105                 110         


Lys Ala Asn Arg Glu Lys Met Thr Gln Ile Met Phe Glu Thr Phe Asn 
        115                 120                 125             


Thr Pro Ala Met Tyr Val Ala Ile Gln Ala Val Leu Ser Leu Tyr Ala 
    130                 135                 140                 


Ser Gly Arg Thr Thr Gly Ile Val Met Asp Ser Gly Asp Gly Val Thr 
145                 150                 155                 160 


His Thr Val Pro Ile Tyr Glu Gly Tyr Ala Leu Pro His Ala Ile Leu 
                165                 170                 175     


Arg Leu Asp Leu Ala Gly Arg Asp Leu Thr Asp Tyr Leu Met Lys Ile 
            180                 185                 190         


Leu Thr Glu Arg Gly Tyr Ser Phe Thr Thr Thr Ala Glu Arg Glu Ile 
        195                 200                 205             


Val Arg Asp Ile Lys Glu Lys Leu Cys Tyr Val Ala Leu Asp Phe Glu 
    210                 215                 220                 


Gln Glu Met Ala Thr Ala Ala Ser Ser Ser Ser Leu Glu Lys Ser Tyr 
225                 230                 235                 240 


Glu Leu Pro Asp Gly Gln Val Ile Thr Ile Gly Asn Glu Arg Phe Arg 
                245                 250                 255     


Cys Pro Glu Ala Leu Phe Gln Pro Ser Phe Leu Gly Met Glu Ser Cys 
            260                 265                 270         


Gly Ile His Glu Thr Thr Phe Asn Ser Ile Met Lys Cys Asp Val Asp 
        275                 280                 285             


Ile Arg Lys Asp Leu Tyr Ala Asn Thr Val Leu Ser Gly Gly Thr Thr 
    290                 295                 300                 


Met Tyr Pro Gly Ile Ala Asp Arg Met Gln Lys Glu Ile Thr Ala Leu 
305                 310                 315                 320 


Ala Pro Ser Thr Met Lys Ile Lys Ile Ile Ala Pro Pro Glu Arg Lys 
                325                 330                 335     


Tyr Ser Val Trp Ile Gly Gly Ser Ile Leu Ala Ser Leu Ser Thr Phe 
            340                 345                 350         


Gln Gln Met Trp Ile Ser Lys Gln Glu Tyr Asp Glu Ser Gly Pro Ser 
        355                 360                 365             


Ile Val His Arg Lys Cys Phe 
    370                 375 


<210> 148
<211> 1935
<212> DNA
<213> Mus musculus

<400> 148
tataaaaccc ggcggcgcaa cgcgcagcca ctgtcgagtc gcgtccaccc gcgagcacag       60

cttctttgca gctccttcgt tgccggtcca cacccgccac cagttcgcca tggatgacga      120

tatcgctgcg ctggtcgtcg acaacggctc cggcatgtgc aaagccggct tcgcgggcga      180

cgatgctccc cgggctgtat tcccctccat cgtgggccgc cctaggcacc agggtgtgat      240

ggtgggaatg ggtcagaagg actcctatgt gggtgacgag gcccagagca agagaggtat      300

cctgaccctg aagtacccca ttgaacatgg cattgttacc aactgggacg acatggagaa      360

gatctggcac cacaccttct acaatgagct gcgtgtggcc cctgaggagc accctgtgct      420

gctcaccgag gcccccctga accctaaggc caaccgtgaa aagatgaccc agatcatgtt      480

tgagaccttc aacaccccag ccatgtacgt agccatccag gctgtgctgt ccctgtatgc      540

ctctggtcgt accacaggca ttgtgatgga ctccggagac ggggtcaccc acactgtgcc      600

catctacgag ggctatgctc tccctcacgc catcctgcgt ctggacctgg ctggccggga      660

cctgacagac tacctcatga agatcctgac cgagcgtggc tacagcttca ccaccacagc      720

tgagagggaa atcgtgcgtg acatcaaaga gaagctgtgc tatgttgctc tagacttcga      780

gcaggagatg gccactgccg catcctcttc ctccctggag aagagctatg agctgcctga      840

cggccaggtc atcactattg gcaacgagcg gttccgatgc cctgaggctc ttttccagcc      900

ttccttcttg ggtatggaat cctgtggcat ccatgaaact acattcaatt ccatcatgaa      960

gtgtgacgtt gacatccgta aagacctcta tgccaacaca gtgctgtctg gtggtaccac     1020

catgtaccca ggcattgctg acaggatgca gaaggagatt actgctctgg ctcctagcac     1080

catgaagatc aagatcattg ctcctcctga gcgcaagtac tctgtgtgga tcggtggctc     1140

catcctggcc tcactgtcca ccttccagca gatgtggatc agcaagcagg agtacgatga     1200

gtccggcccc tccatcgtgc accgcaagtg cttctaggcg gactgttact gagctgcgtt     1260

ttacaccctt tctttgacaa aacctaactt gcgcagaaaa aaaaaaaata agagacaaca     1320

ttggcatggc tttgtttttt taaatttttt ttaaagtttt tttttttttt tttttttttt     1380

tttttaagtt tttttgtttt gttttggcgc ttttgactca ggatttaaaa actggaacgg     1440

tgaaggcgac agcagttggt tggagcaaac atcccccaaa gttctacaaa tgtggctgag     1500

gactttgtac attgttttgt tttttttttt ttttggtttt gtcttttttt aatagtcatt     1560

ccaagtatcc atgaaataag tggttacagg aagtccctca ccctcccaaa agccaccccc     1620

actcctaaga ggaggatggt cgcgtccatg ccctgagtcc accccgggga aggtgacagc     1680

attgcttctg tgtaaattat gtactgcaaa aattttttta aatcttccgc cttaatactt     1740

catttttgtt tttaatttct gaatggccca ggtctgaggc ctcccttttt tttgtccccc     1800

caacttgatg tatgaaggct ttggtctccc tgggaggggg ttgaggtgtt gaggcagcca     1860

gggctggcct gtacactgac ttgagaccaa taaaagtgca caccttacct tacacaaaca     1920

aaaaaaaaaa aaaaa                                                      1935


<210> 149
<211> 375
<212> PRT
<213> Mus musculus

<400> 149
Met Asp Asp Asp Ile Ala Ala Leu Val Val Asp Asn Gly Ser Gly Met 
1               5                   10                  15      


Cys Lys Ala Gly Phe Ala Gly Asp Asp Ala Pro Arg Ala Val Phe Pro 
            20                  25                  30          


Ser Ile Val Gly Arg Pro Arg His Gln Gly Val Met Val Gly Met Gly 
        35                  40                  45              


Gln Lys Asp Ser Tyr Val Gly Asp Glu Ala Gln Ser Lys Arg Gly Ile 
    50                  55                  60                  


Leu Thr Leu Lys Tyr Pro Ile Glu His Gly Ile Val Thr Asn Trp Asp 
65                  70                  75                  80  


Asp Met Glu Lys Ile Trp His His Thr Phe Tyr Asn Glu Leu Arg Val 
                85                  90                  95      


Ala Pro Glu Glu His Pro Val Leu Leu Thr Glu Ala Pro Leu Asn Pro 
            100                 105                 110         


Lys Ala Asn Arg Glu Lys Met Thr Gln Ile Met Phe Glu Thr Phe Asn 
        115                 120                 125             


Thr Pro Ala Met Tyr Val Ala Ile Gln Ala Val Leu Ser Leu Tyr Ala 
    130                 135                 140                 


Ser Gly Arg Thr Thr Gly Ile Val Met Asp Ser Gly Asp Gly Val Thr 
145                 150                 155                 160 


His Thr Val Pro Ile Tyr Glu Gly Tyr Ala Leu Pro His Ala Ile Leu 
                165                 170                 175     


Arg Leu Asp Leu Ala Gly Arg Asp Leu Thr Asp Tyr Leu Met Lys Ile 
            180                 185                 190         


Leu Thr Glu Arg Gly Tyr Ser Phe Thr Thr Thr Ala Glu Arg Glu Ile 
        195                 200                 205             


Val Arg Asp Ile Lys Glu Lys Leu Cys Tyr Val Ala Leu Asp Phe Glu 
    210                 215                 220                 


Gln Glu Met Ala Thr Ala Ala Ser Ser Ser Ser Leu Glu Lys Ser Tyr 
225                 230                 235                 240 


Glu Leu Pro Asp Gly Gln Val Ile Thr Ile Gly Asn Glu Arg Phe Arg 
                245                 250                 255     


Cys Pro Glu Ala Leu Phe Gln Pro Ser Phe Leu Gly Met Glu Ser Cys 
            260                 265                 270         


Gly Ile His Glu Thr Thr Phe Asn Ser Ile Met Lys Cys Asp Val Asp 
        275                 280                 285             


Ile Arg Lys Asp Leu Tyr Ala Asn Thr Val Leu Ser Gly Gly Thr Thr 
    290                 295                 300                 


Met Tyr Pro Gly Ile Ala Asp Arg Met Gln Lys Glu Ile Thr Ala Leu 
305                 310                 315                 320 


Ala Pro Ser Thr Met Lys Ile Lys Ile Ile Ala Pro Pro Glu Arg Lys 
                325                 330                 335     


Tyr Ser Val Trp Ile Gly Gly Ser Ile Leu Ala Ser Leu Ser Thr Phe 
            340                 345                 350         


Gln Gln Met Trp Ile Ser Lys Gln Glu Tyr Asp Glu Ser Gly Pro Ser 
        355                 360                 365             


Ile Val His Arg Lys Cys Phe 
    370                 375 


<210> 150
<211> 3783
<212> DNA
<213> Homo sapiens

<400> 150
actgggccag gcgcgcggcg gccccgggct ttgtgtgtgt gtgtatgtgt gtgtgtgtgt       60

gtgtgtgtgt gtgagtgtgt gcgtgtgaga gtgcgagtgt ctgtgcgcga gtgagtgagc      120

ggcgggcggg cgcgagtgtg gccgccgcgg agcgcgagca ggacccggcg ggcgcgctcc      180

ccagcctccg tctccccgcc ggaaccatgt cgggcaggtc ggttcgagcc gagacgagga      240

gccgggccaa agatgatatc aagagggtca tggcggcgat cgagaaagtg cgcaaatggg      300

agaagaaatg ggtgaccgtt ggtgacacat ccctacgaat ctacaaatgg gtccctgtga      360

cggagcccaa ggttgatgac aaaaacaaga ataagaaaaa aggcaaggac gagaagtgtg      420

gctcagaggt gaccactccg gagaacagtt cctccccagg gatgatggac atgcatgacg      480

ataacagcaa ccagagctcc atcgcagatg cctcccccat caaacaggag aacagcagca      540

actccagccc cgctccagag cccaactcgg ctgtgcccag cgacggcacc gaggccaagg      600

tggatgaggc ccaggctgat gggaaggagc acccaggagc tgaagatgct tctgatgagc      660

agaattcaca gtcctcgatg gaacattcga tgaacagctc agagaaagta gatcggcagc      720

cgtctggaga ctcgggtctg gccgcagaga cgtctgcaat ctctcaggta cctcgctcga      780

ggtctcagag gggcagccag atcggccggg agcccattgg gttgtcgggg gatttggaag      840

gagtgccacc ctctaaaaag atgaaactgg aggcctctca acaaaactcc gaagagatgt      900

agacgatgct ttaaagcctc cgatccatgt tccatggaag gtacatcagc aattaattct      960

agagcaactt tgccccagcg attcctcttg ggtgcgaaca gaactactaa cgtttcaagt     1020

ttaccaagtg caaatccaag aagacccaga acggcgtcac ttctcagaca ctgaagaact     1080

ctgctgtgaa gcaaaacact caaaccttta agggactgtc cttggggagg caggcggggc     1140

tgacagctca ggagtgtctg cacactgtct cggaagccag gattccattt gtgttgctgc     1200

tgtattttcc ccccacttct ctatgtaacg atataagcta tcggagggtg gtaccgatca     1260

ggaacgcttt ttggcggggc tttccactgt tcaaccgatt ccttccgctt tctttttttg     1320

tgccttgtgc ccttgaggtg acctctggca tgtatcctgg tggttcttac atccccctct     1380

gcaaagtgcc ctcttggttt ggttcgggcg gcggctgcca ccctactcac cgctctcctc     1440

cctgccccag gacttcatcg gagcaggcag ggtggagcga aggagctcct tagcccacct     1500

ggtttgcagg tgcaggggga ccttaggcac gccccaagca ccaggcacca gggcccaagg     1560

acgcgcaggt gttggggcac agtccccaag ggctcggccc cttggatcag gctgggcact     1620

cgctgtgctc tcccctcctt ggggcgttta ggactgggcg tctccaagcc caccatggcc     1680

cagatggacg tgcaaagccc ttggaatttt ctggcacttc ctctctattg cccccaccac     1740

caccaccccc atcactgctt tctcccagac ctccgaatac gaaatggctt ctctggctga     1800

ctgcaaggct gtctccttaa ggcactgagt gggccgggga ggctgggagc cggcggcagg     1860

attagctggt gctgaacttt ctctcatagg acgtcgcttg gatttcaaat ccacggtcac     1920

ctgctgccct ttgcctcccc cgacgcccca gcctgtgccc cggagaggca ggatcgcagt     1980

ggtcagaatc cacgtgcttt cctattctca ggctgttctg actctgagcc aacagctgga     2040

ccgtgtctca tccccagaac atgccgtctg tccccaccgg ggagtgggcc ttgatggccg     2100

ggcctcgaag gccacaaaca aggcgtcgag gaattggaaa gatttgcaca ccctccagaa     2160

aggagagacg caatctcccc tccctcccat cccccacctt cgctggaaca gcttcctctc     2220

actgaacgga gacgccccct tggacgaact gcctaatcgt ttggttctga ggcctggttt     2280

gctcttaatt aatatatgaa ctcctcagac cttaaacctt ttcctaagct ttctttactg     2340

cactggagtt ctgactccct ttgagttgtg tgttactggg ggtggggtgg ggtcatgggt     2400

tttgttgttt ttgggggcta attggtgcat attcaggtac cacctttgac gtgtggctct     2460

ttctcctgac catcatggga agtgtctgct ggattccatt ttctaagagt ttctgagggt     2520

gaggctctta tttttttttt taagggatcc tgtctatttc ctgcacttcg agaagaatca     2580

aaatgttcct gaatttcaaa tacctcatgc aaaatgtctc ctgaaataag ggaaaaaaaa     2640

aaaaccacaa ctttgaaaat cttaatgttg aagttagcaa tgccgaaagg tttctgtctt     2700

aaaaaaaaaa atccttgtac ttatcaattt tgccccttag gcagtcagtt ttgttgagaa     2760

ctgtgtcctg catcctggcg cagaacctac ctgatgcggt tcctctccac gcatctcgag     2820

gcggcgttac ctccagattc cgtagagtta gagtcacatt tttctttgca gcgaaactcc     2880

atcttggtga gagatgaatt tggatattta tttccttctc tgtttttggg aaacgagagg     2940

ctacaaccaa gacagctgaa ggagaatgaa acacacacat ccacagaaac agagaggcgt     3000

aggtggccct gccgttgacc gcagcctctc tggacaggca aggggagttg gcgcaggtga     3060

ggactcagac gacgtccacc gtcccaaggc tgtcactagt atttctctga agtgcctgaa     3120

ggtaggaatg ggccggcgat tgggaccagc tgggccccac cacggccacg ccaggcaaag     3180

cgccagcagc cctgcactcc acgctggcca agaaggcctt ccacgcagaa tgacaagact     3240

gcaaaaatcc gatgtgcttc cttccctggc gcagtcgctc ctcgagccgc tgccccccac     3300

ccaccctgca cccctcgccc tccccccacc acagaatcta agacctttca gcttcgagcc     3360

agggggcggg ggatcccgag caaaagcctt ccgtggacat caggccccgt ggcctcaagg     3420

gctcccaggg caaacctaat tccccccaaa acgtgaagtc ggggaagctg cggctacaca     3480

ttccacaaag tgctggcact tacacccaca acccggaagg ctgtggaccg attcctctag     3540

ggtggtgacc tcccattagc aaacggtgtc atggtttgga atgttcatta tcgccaagaa     3600

cctggttaga ggcataaaga ccttttttca ccgttaccta attttttccc ctttcaagaa     3660

tttttttttt ttttggtgtg ttgtacagca gtataatttt tcacttattt attccatcag     3720

tagatatggt ttgtacaatg tacaattgtt tcatttcaga aaataaaaat ttcaaatcat     3780

gaa                                                                   3783


<210> 151
<211> 231
<212> PRT
<213> Homo sapiens

<400> 151
Met Ser Gly Arg Ser Val Arg Ala Glu Thr Arg Ser Arg Ala Lys Asp 
1               5                   10                  15      


Asp Ile Lys Arg Val Met Ala Ala Ile Glu Lys Val Arg Lys Trp Glu 
            20                  25                  30          


Lys Lys Trp Val Thr Val Gly Asp Thr Ser Leu Arg Ile Tyr Lys Trp 
        35                  40                  45              


Val Pro Val Thr Glu Pro Lys Val Asp Asp Lys Asn Lys Asn Lys Lys 
    50                  55                  60                  


Lys Gly Lys Asp Glu Lys Cys Gly Ser Glu Val Thr Thr Pro Glu Asn 
65                  70                  75                  80  


Ser Ser Ser Pro Gly Met Met Asp Met His Asp Asp Asn Ser Asn Gln 
                85                  90                  95      


Ser Ser Ile Ala Asp Ala Ser Pro Ile Lys Gln Glu Asn Ser Ser Asn 
            100                 105                 110         


Ser Ser Pro Ala Pro Glu Pro Asn Ser Ala Val Pro Ser Asp Gly Thr 
        115                 120                 125             


Glu Ala Lys Val Asp Glu Ala Gln Ala Asp Gly Lys Glu His Pro Gly 
    130                 135                 140                 


Ala Glu Asp Ala Ser Asp Glu Gln Asn Ser Gln Ser Ser Met Glu His 
145                 150                 155                 160 


Ser Met Asn Ser Ser Glu Lys Val Asp Arg Gln Pro Ser Gly Asp Ser 
                165                 170                 175     


Gly Leu Ala Ala Glu Thr Ser Ala Ile Ser Gln Val Pro Arg Ser Arg 
            180                 185                 190         


Ser Gln Arg Gly Ser Gln Ile Gly Arg Glu Pro Ile Gly Leu Ser Gly 
        195                 200                 205             


Asp Leu Glu Gly Val Pro Pro Ser Lys Lys Met Lys Leu Glu Ala Ser 
    210                 215                 220                 


Gln Gln Asn Ser Glu Glu Met 
225                 230     


<210> 152
<211> 3720
<212> DNA
<213> Homo sapiens

<400> 152
actgggccag gcgcgcggcg gccccgggct ttgtgtgtgt gtgtatgtgt gtgtgtgtgt       60

gtgtgtgtgt gtgagtgtgt gcgtgtgaga gtgcgagtgt ctgtgcgcga gtgagtgagc      120

ggcgggcggg cgcgagtgtg gccgccgcgg agcgcgagca ggacccggcg ggcgcgctcc      180

ccagcctccg tctccccgcc ggaaccatgt cgggcaggtc ggttcgagcc gagacgagga      240

gccgggccaa agatgatatc aagagggtca tggcggcgat cgagaaagtg cgcaaatggg      300

agaagaaatg ggtgaccgtt ggtgacacat ccctacgaat ctacaaatgg gtccctgtga      360

cggagcccaa ggttgatgac aaaaacaaga ataagaaaaa aggcaaggac gagaagtgtg      420

gctcagaggt gaccactccg gagaacagtt cctccccagg gatgatggac atgcatgacg      480

ataacagcaa ccagagctcc atcgcagatg cctcccccat caaacaggag aacagcagca      540

actccagccc cgctccagag cccaactcgg ctgtgcccag cgacggcacc gaggccaagg      600

tggatgaggc ccaggctgat gggaaggagc acccaggagc tgaagatgct tctgatgagc      660

agaattcaca gtcctcgatg gaacattcga tgaacagctc agagaaagta gatcggcagc      720

cgtctggaga ctcgggtctg gccgcagaga cgtctgcaat ctctcaggat ttggaaggag      780

tgccaccctc taaaaagatg aaactggagg cctctcaaca aaactccgaa gagatgtaga      840

cgatgcttta aagcctccga tccatgttcc atggaaggta catcagcaat taattctaga      900

gcaactttgc cccagcgatt cctcttgggt gcgaacagaa ctactaacgt ttcaagttta      960

ccaagtgcaa atccaagaag acccagaacg gcgtcacttc tcagacactg aagaactctg     1020

ctgtgaagca aaacactcaa acctttaagg gactgtcctt ggggaggcag gcggggctga     1080

cagctcagga gtgtctgcac actgtctcgg aagccaggat tccatttgtg ttgctgctgt     1140

attttccccc cacttctcta tgtaacgata taagctatcg gagggtggta ccgatcagga     1200

acgctttttg gcggggcttt ccactgttca accgattcct tccgctttct ttttttgtgc     1260

cttgtgccct tgaggtgacc tctggcatgt atcctggtgg ttcttacatc cccctctgca     1320

aagtgccctc ttggtttggt tcgggcggcg gctgccaccc tactcaccgc tctcctccct     1380

gccccaggac ttcatcggag caggcagggt ggagcgaagg agctccttag cccacctggt     1440

ttgcaggtgc agggggacct taggcacgcc ccaagcacca ggcaccaggg cccaaggacg     1500

cgcaggtgtt ggggcacagt ccccaagggc tcggcccctt ggatcaggct gggcactcgc     1560

tgtgctctcc cctccttggg gcgtttagga ctgggcgtct ccaagcccac catggcccag     1620

atggacgtgc aaagcccttg gaattttctg gcacttcctc tctattgccc ccaccaccac     1680

cacccccatc actgctttct cccagacctc cgaatacgaa atggcttctc tggctgactg     1740

caaggctgtc tccttaaggc actgagtggg ccggggaggc tgggagccgg cggcaggatt     1800

agctggtgct gaactttctc tcataggacg tcgcttggat ttcaaatcca cggtcacctg     1860

ctgccctttg cctcccccga cgccccagcc tgtgccccgg agaggcagga tcgcagtggt     1920

cagaatccac gtgctttcct attctcaggc tgttctgact ctgagccaac agctggaccg     1980

tgtctcatcc ccagaacatg ccgtctgtcc ccaccgggga gtgggccttg atggccgggc     2040

ctcgaaggcc acaaacaagg cgtcgaggaa ttggaaagat ttgcacaccc tccagaaagg     2100

agagacgcaa tctcccctcc ctcccatccc ccaccttcgc tggaacagct tcctctcact     2160

gaacggagac gcccccttgg acgaactgcc taatcgtttg gttctgaggc ctggtttgct     2220

cttaattaat atatgaactc ctcagacctt aaaccttttc ctaagctttc tttactgcac     2280

tggagttctg actccctttg agttgtgtgt tactgggggt ggggtggggt catgggtttt     2340

gttgtttttg ggggctaatt ggtgcatatt caggtaccac ctttgacgtg tggctctttc     2400

tcctgaccat catgggaagt gtctgctgga ttccattttc taagagtttc tgagggtgag     2460

gctcttattt ttttttttaa gggatcctgt ctatttcctg cacttcgaga agaatcaaaa     2520

tgttcctgaa tttcaaatac ctcatgcaaa atgtctcctg aaataaggga aaaaaaaaaa     2580

accacaactt tgaaaatctt aatgttgaag ttagcaatgc cgaaaggttt ctgtcttaaa     2640

aaaaaaaatc cttgtactta tcaattttgc cccttaggca gtcagttttg ttgagaactg     2700

tgtcctgcat cctggcgcag aacctacctg atgcggttcc tctccacgca tctcgaggcg     2760

gcgttacctc cagattccgt agagttagag tcacattttt ctttgcagcg aaactccatc     2820

ttggtgagag atgaatttgg atatttattt ccttctctgt ttttgggaaa cgagaggcta     2880

caaccaagac agctgaagga gaatgaaaca cacacatcca cagaaacaga gaggcgtagg     2940

tggccctgcc gttgaccgca gcctctctgg acaggcaagg ggagttggcg caggtgagga     3000

ctcagacgac gtccaccgtc ccaaggctgt cactagtatt tctctgaagt gcctgaaggt     3060

aggaatgggc cggcgattgg gaccagctgg gccccaccac ggccacgcca ggcaaagcgc     3120

cagcagccct gcactccacg ctggccaaga aggccttcca cgcagaatga caagactgca     3180

aaaatccgat gtgcttcctt ccctggcgca gtcgctcctc gagccgctgc cccccaccca     3240

ccctgcaccc ctcgccctcc ccccaccaca gaatctaaga cctttcagct tcgagccagg     3300

gggcggggga tcccgagcaa aagccttccg tggacatcag gccccgtggc ctcaagggct     3360

cccagggcaa acctaattcc ccccaaaacg tgaagtcggg gaagctgcgg ctacacattc     3420

cacaaagtgc tggcacttac acccacaacc cggaaggctg tggaccgatt cctctagggt     3480

ggtgacctcc cattagcaaa cggtgtcatg gtttggaatg ttcattatcg ccaagaacct     3540

ggttagaggc ataaagacct tttttcaccg ttacctaatt ttttcccctt tcaagaattt     3600

tttttttttt tggtgtgttg tacagcagta taatttttca cttatttatt ccatcagtag     3660

atatggtttg tacaatgtac aattgtttca tttcagaaaa taaaaatttc aaatcatgaa     3720


<210> 153
<211> 210
<212> PRT
<213> Homo sapiens

<400> 153
Met Ser Gly Arg Ser Val Arg Ala Glu Thr Arg Ser Arg Ala Lys Asp 
1               5                   10                  15      


Asp Ile Lys Arg Val Met Ala Ala Ile Glu Lys Val Arg Lys Trp Glu 
            20                  25                  30          


Lys Lys Trp Val Thr Val Gly Asp Thr Ser Leu Arg Ile Tyr Lys Trp 
        35                  40                  45              


Val Pro Val Thr Glu Pro Lys Val Asp Asp Lys Asn Lys Asn Lys Lys 
    50                  55                  60                  


Lys Gly Lys Asp Glu Lys Cys Gly Ser Glu Val Thr Thr Pro Glu Asn 
65                  70                  75                  80  


Ser Ser Ser Pro Gly Met Met Asp Met His Asp Asp Asn Ser Asn Gln 
                85                  90                  95      


Ser Ser Ile Ala Asp Ala Ser Pro Ile Lys Gln Glu Asn Ser Ser Asn 
            100                 105                 110         


Ser Ser Pro Ala Pro Glu Pro Asn Ser Ala Val Pro Ser Asp Gly Thr 
        115                 120                 125             


Glu Ala Lys Val Asp Glu Ala Gln Ala Asp Gly Lys Glu His Pro Gly 
    130                 135                 140                 


Ala Glu Asp Ala Ser Asp Glu Gln Asn Ser Gln Ser Ser Met Glu His 
145                 150                 155                 160 


Ser Met Asn Ser Ser Glu Lys Val Asp Arg Gln Pro Ser Gly Asp Ser 
                165                 170                 175     


Gly Leu Ala Ala Glu Thr Ser Ala Ile Ser Gln Asp Leu Glu Gly Val 
            180                 185                 190         


Pro Pro Ser Lys Lys Met Lys Leu Glu Ala Ser Gln Gln Asn Ser Glu 
        195                 200                 205             


Glu Met 
    210 


<210> 154
<211> 3809
<212> DNA
<213> Mus musculus

<400> 154
ttgcgcactg ggccccgggc gcgcggcggc accaggcttt gtgtgtgcgc gtatgtgtgt       60

gagtgtgtgt ctgtgcgcga gtgagagagc gggcgagtgt ggcgagcagg acccggcggg      120

cgcgctcccc cagcctccct ctctctctct ctttcctctc tctctccctc cccgccagaa      180

ccatgtcggg caggtcggtt cgagccgaga ccaggagccg ggccaaagat gatatcaaga      240

gggtcatggc ggctatcgag aaagtgcgca aatgggagaa gaaatgggtg accgttggcg      300

atacatccct acgaatctac aagtgggtcc ctgtgacgga gccaaaggtt gatgataaaa      360

acaagaacaa gaagaaaggc aaggacgaga agtgtggctc ggaggtgacc actccagaga      420

acagctcgtc tcctgggatg atggacatgc acgatgataa cagcaaccag agctccatag      480

cagacgcctc ccccatcaag caagagaaca gcagcaactc cagccctgcc ccagagacca      540

acccacccgt gcccagcgat ggcaccgaag ccaaggctga tgaggcgcag gccgatggaa      600

aagagcaccc tggagctgaa gatgcatccg aggagcaaaa ttcacagtct tcgatggaaa      660

actcggtgaa cagctccgag aaggcagaac ggcagccatc tgcagaatca gggttagcgg      720

cagaaacgtc ggcagtctct caggatttgg aaggagtgcc gccgtctaaa aagatgaagc      780

tggaagcctc tcaacagaac tcagaagaga tgtagacggc ccggcggaac cttctggtcc      840

atgtttcatg gcaggtacat cggcaggctt aattctagaa acacggccca agcgactcct      900

cttgggcgcg agcagaacta acgtttcaag tttactaaag tgcaaatcca agaagaacct      960

agagcggcgg cggcagcgga acttcgcaga cacttgacgg actctgccgt gaaaccgaaa     1020

cactcgaacc ttcaagtgac tgccctctgg gaggtgggtc gacagctcag gagtgtgtgc     1080

gcactgtctc ggaagccaag attacatttg tgttgctgct gtatccccct cccctcactt     1140

ctctatttaa cgatataagc tattcgaggg tggtaccaat caggaatttg ctttccatag     1200

gggcttttgg ctcttcaacc aattccttct gctttctttt tttgtgcctt gtaccctaga     1260

ggtgacctcc ggcatgcttc ctggtttttg catctctcct ggcaaagtgc ccacttgttt     1320

tggttggctg ctgcccccac ccccacccct tattgcctct ctcctccctg ccccaagact     1380

gcttcaaagc aagcagggta gagcggcggg agaccaggca cctttcagtg acccccttgg     1440

ttcaggtgag cagtgtttgg gcacaccctg agccccaact tccagggccc ctggggctac     1500

aagtttgcgg gggccggttt cccgagggct ggcctccttg gtcaggacac gccctcacct     1560

tttggagcca tggaggctag gcgtttgcaa ggcaaggtag cccagattga catgcaaaag     1620

cctttagatt tttctggcac ttccacccta tctcccctcc gccccctaac ctcacacccc     1680

gactctggcc acaactggca ctgcgctctc caggtcctcc gaagacgaaa tgaccaactg     1740

agcttgtctc cttaggatag taaagggctg ggaggttggg agccggcggc cggcaggaat     1800

agctggtgct gaactaactc tcccatagga cattgcttgg atttcaaatc catggtaacc     1860

tgctgccctt tgtccctgtc tcctatccac cgcaccccaa gccccccaaa accccaggca     1920

ggatgcgcct ggtatggcct gactctgaga ggctacaggt ggatggagac ccattcccag     1980

taccgcgctg ttggtctcct ctggggaccg gaccttaacc attgggcctc aggccagaag     2040

caaggcacag aggaaccggg aagatttgca cacagatttg cccccccaga aaggagcctc     2100

cgaggcactt ccttcccctg ctcttccttg cacggagaca gctctctctc actcagtgga     2160

gacgccactt ggacagacgg actgctcagc tgttgatttc tgaggcctgg tttgctctta     2220

atccctttgc tggacccctc agatctgaaa accttcccct atgctttctt actgcactgg     2280

agttcgaact ccctatgagt tgtgtgttgg ggggaggggc gggcggggtg ggttttgttt     2340

ttttgttgtt cttgtttcgt tttgtttcgt ttgctaattg gtgcatattc aggtaccacc     2400

ttttgacgtg tggatctttc tccaaaccac cacaagaagt gtctgccggg ctccgttttc     2460

taagagtttc tgaggggaca gctcccattt ctttttttgg tttcaaggga gctgtctatt     2520

tcctatactt caagaagaat caaaatgttc ctgaatttta aatacctcat gcaaaaatat     2580

ctcctgaaat aagggaaaaa aaaaaaactt tgaaaaatcg taatgttgaa gttagcgatg     2640

ctaaaatgtt tctgtcttaa aaaacaaaaa aattgttgta atacttagcg attttgcccc     2700

tcaggcggtc agttctgtcc agaactgtgt tctgcgtctt ggcccggaag caaccggatg     2760

catgacctct gaacggatct caaggccaag gcatctttac ctccagattc tagagttagg     2820

gcaacaacag ttttcttttg cagcaaaact ccgttctggt gaaagatgaa tttggatatt     2880

tatttctttt tctgggaaac aagaggttaa acaacgtaag cagctgaggg agaacccaac     2940

acgggcatcc acggaaccag cgggcgcggc cagggccgcc tatacctctt ctaccctccg     3000

cagcctctct ggacagtcag gaggagtcga tacagttgag aaagaagaca acgatgaggt     3060

tcgaggtacc gaggctgtca ttagtttttc tctgaagtgc ctgaacgtag gaatgggccg     3120

tcgacggagg ggaccattcg gatgttcccc cacctcgcga cggccgcgcc aggcaaagag     3180

ccagcagccc tgcactccac actggccagg aaaagccttc cacgaggagc ggtcagactg     3240

caaaatccaa tgtgcttcct tccccgccac ggtcctctct ctctctcggg gagccgatgg     3300

tccccgtccc tgaaccccct agcccgcatc cccaccacag aatctaagac ctttcatctg     3360

gccgagccag gggcaaaggg gatcctaagc aaatgccttc cgtggacaac aggccccacg     3420

gcctaaaggg ctcccagggc aaactttccc ccaacacttg aaggggggtg ggggggatgg     3480

cggctacaca ttccactaag tgcagcactc gcacccacaa cccggaagga aggctcttaa     3540

gcgattctca gagggtggtg actgcccatc atcgtcagac ggtgtcgtgg tttggaatgt     3600

taattatcgc agaggacctg gtagaggtat aaagaccttt tttcactgtt acctaatttt     3660

ttttttcctc ttacaatttt ttttttggtg tgttgtacag cagtataatt tttcacttat     3720

ttattccatc ggtagatatt gtttgtacaa tgtacaatgg tttcatttca gaaaataata     3780

ataataaaaa aaaaagttct gatcatgag                                       3809


<210> 155
<211> 210
<212> PRT
<213> Mus musculus

<400> 155
Met Ser Gly Arg Ser Val Arg Ala Glu Thr Arg Ser Arg Ala Lys Asp 
1               5                   10                  15      


Asp Ile Lys Arg Val Met Ala Ala Ile Glu Lys Val Arg Lys Trp Glu 
            20                  25                  30          


Lys Lys Trp Val Thr Val Gly Asp Thr Ser Leu Arg Ile Tyr Lys Trp 
        35                  40                  45              


Val Pro Val Thr Glu Pro Lys Val Asp Asp Lys Asn Lys Asn Lys Lys 
    50                  55                  60                  


Lys Gly Lys Asp Glu Lys Cys Gly Ser Glu Val Thr Thr Pro Glu Asn 
65                  70                  75                  80  


Ser Ser Ser Pro Gly Met Met Asp Met His Asp Asp Asn Ser Asn Gln 
                85                  90                  95      


Ser Ser Ile Ala Asp Ala Ser Pro Ile Lys Gln Glu Asn Ser Ser Asn 
            100                 105                 110         


Ser Ser Pro Ala Pro Glu Thr Asn Pro Pro Val Pro Ser Asp Gly Thr 
        115                 120                 125             


Glu Ala Lys Ala Asp Glu Ala Gln Ala Asp Gly Lys Glu His Pro Gly 
    130                 135                 140                 


Ala Glu Asp Ala Ser Glu Glu Gln Asn Ser Gln Ser Ser Met Glu Asn 
145                 150                 155                 160 


Ser Val Asn Ser Ser Glu Lys Ala Glu Arg Gln Pro Ser Ala Glu Ser 
                165                 170                 175     


Gly Leu Ala Ala Glu Thr Ser Ala Val Ser Gln Asp Leu Glu Gly Val 
            180                 185                 190         


Pro Pro Ser Lys Lys Met Lys Leu Glu Ala Ser Gln Gln Asn Ser Glu 
        195                 200                 205             


Glu Met 
    210 


<210> 156
<211> 1729
<212> DNA
<213> Homo sapiens

<400> 156
gcgggcgggt gcgcgcgctt tctcgcgcac gcgcgcacgg agggggcgac ggccgctgtg       60

acgctgcggc ggcggcgggc gggcggcggc gcgtgaggcg cgcgatcccc ggtgtcttgg      120

gagcagtgcc ccggcccccg ccgctcccgc cgccgccatg tcgggccggt cggtccgggc      180

ggagacccgc agccgggcca aggacgacat caagaaggtg atggcggcca tcgagaaagt      240

gcggaaatgg gagaagaagt gggtgactgt gggtgacacg tccctgagga tatttaagtg      300

ggttcctgtg acagacagca aggagaaaga aaagtcaaaa tcgaacagtt cagcagcccg      360

agaacctaat ggctttcctt ctgatgcctc agccaattcc tctctccttc ttgaattcca      420

ggacgaaaac agcaaccaga gttccgtgtc tgacgtctat cagcttaagg tggacagcag      480

caccaactca agccccagcc cccagcagag tgagtccctg agcccagcac acacctccga      540

cttccgcacg gatgactccc agcccccaac gctgggccag gagatcctgg aggagccctc      600

cctgccctcc tcggaagttg ctgatgaacc tcctaccctc accaaggaag aaccagttcc      660

actagagaca caggtcgttg aggaagagga agactcaggt gccccgcccc tgaagcgctt      720

ctgtgtggac caacccacag tgccgcagac ggcgtcagaa agctagcacc atcccggccc      780

tccgcctcct ggccctgcct ctatttattg cattctggtt ctggccgcgc cgcgttgctg      840

gggtaagggc aagcactggg gtcaagagcc tgcacacatg agccttccgg gctggaaggc      900

tggcgtagga cttggggctg tagcatcatc ttcctgaccc tggcacctgt gtctacttgc      960

tcccgagaag aggagcgctc atgtcttttt tgcaccccaa gttggctgga gcatcggcca     1020

ccccaagatt catctgtgac ctccaggcag cagtctctgc tccagaatct ctggacggag     1080

ctgctggcag cttctgcgag aagagagaga tgtggaaggc accttctaga agagagcgtg     1140

cctcaggtta cttgaacttg aacggagact gtagactccc ggactttccc ctaggactgg     1200

gggccctgta ggctgctgtt ggaggactgg gtagagacat tggagggaag ggaagggctt     1260

ttctccacac aagggcagag agtccgtcta gatttcttgc tgtcctgcca gctctgccca     1320

tgcctgaggt ggtcctacct ctcacgggca ccctagctgc tgacagccct ttgtggccgc     1380

cgtccccatc ccctgccctc agcacacaca tctgcacaca cgcagctttg ttctcacctc     1440

tacctgtcat tccagcatcc ctgcctcttg tcacaaactg ccccagcaag aatttgaggt     1500

tctgacaaca gtacccatcc cccacagtac cccttcagct cagtttctag aaagctccct     1560

tttctttgaa atctgcatgt tgaattgaac tttgtgattt tattttttgt ttcaaaaaag     1620

tttaagaaaa tggaaatggg caacagtgag tgaagacata ttttagcact gaatagaata     1680

tttttaaaat taaactattt gaaatatgtc caaaaaaaaa aaaaaaaaa                 1729


<210> 157
<211> 202
<212> PRT
<213> Homo sapiens

<400> 157
Met Ser Gly Arg Ser Val Arg Ala Glu Thr Arg Ser Arg Ala Lys Asp 
1               5                   10                  15      


Asp Ile Lys Lys Val Met Ala Ala Ile Glu Lys Val Arg Lys Trp Glu 
            20                  25                  30          


Lys Lys Trp Val Thr Val Gly Asp Thr Ser Leu Arg Ile Phe Lys Trp 
        35                  40                  45              


Val Pro Val Thr Asp Ser Lys Glu Lys Glu Lys Ser Lys Ser Asn Ser 
    50                  55                  60                  


Ser Ala Ala Arg Glu Pro Asn Gly Phe Pro Ser Asp Ala Ser Ala Asn 
65                  70                  75                  80  


Ser Ser Leu Leu Leu Glu Phe Gln Asp Glu Asn Ser Asn Gln Ser Ser 
                85                  90                  95      


Val Ser Asp Val Tyr Gln Leu Lys Val Asp Ser Ser Thr Asn Ser Ser 
            100                 105                 110         


Pro Ser Pro Gln Gln Ser Glu Ser Leu Ser Pro Ala His Thr Ser Asp 
        115                 120                 125             


Phe Arg Thr Asp Asp Ser Gln Pro Pro Thr Leu Gly Gln Glu Ile Leu 
    130                 135                 140                 


Glu Glu Pro Ser Leu Pro Ser Ser Glu Val Ala Asp Glu Pro Pro Thr 
145                 150                 155                 160 


Leu Thr Lys Glu Glu Pro Val Pro Leu Glu Thr Gln Val Val Glu Glu 
                165                 170                 175     


Glu Glu Asp Ser Gly Ala Pro Pro Leu Lys Arg Phe Cys Val Asp Gln 
            180                 185                 190         


Pro Thr Val Pro Gln Thr Ala Ser Glu Ser 
        195                 200         


<210> 158
<211> 1558
<212> DNA
<213> Homo sapiens

<400> 158
gcgggcgggt gcgcgcgctt tctcgcgcac gcgcgcacgg agggggcgac ggccgctgtg       60

acgctgcggc ggcggcgggc gggcggcggc gcgtgaggcg cgcgatcccc ggtgtcttgg      120

gagcagtgcc ccggcccccg ccgctcccgc cgccgccatg tcgggccggt cggtccgggc      180

ggagacccgc agccgggcca aggacgacat caagaaggtg atggcggcca tcgagaaagt      240

gcggaaatgg gagaagaagt gggtgactgt gggtgacacg tccctgagga tatttaagtg      300

ggttcctgtg acagacagca aggagaaaga aaagtcaaaa tcgaacagtt cagcagcccg      360

agaacctaat ggctttcctt ctgatgcctc agccaattcc tctctccttc ttgaattcca      420

ggagccctcc ctgccctcct cggaagttgc tgatgaacct cctaccctca ccaaggaaga      480

accagttcca ctagagacac aggtcgttga ggaagaggaa gactcaggtg ccccgcccct      540

gaagcgcttc tgtgtggacc aacccacagt gccgcagacg gcgtcagaaa gctagcacca      600

tcccggccct ccgcctcctg gccctgcctc tatttattgc attctggttc tggccgcgcc      660

gcgttgctgg ggtaagggca agcactgggg tcaagagcct gcacacatga gccttccggg      720

ctggaaggct ggcgtaggac ttggggctgt agcatcatct tcctgaccct ggcacctgtg      780

tctacttgct cccgagaaga ggagcgctca tgtctttttt gcaccccaag ttggctggag      840

catcggccac cccaagattc atctgtgacc tccaggcagc agtctctgct ccagaatctc      900

tggacggagc tgctggcagc ttctgcgaga agagagagat gtggaaggca ccttctagaa      960

gagagcgtgc ctcaggttac ttgaacttga acggagactg tagactcccg gactttcccc     1020

taggactggg ggccctgtag gctgctgttg gaggactggg tagagacatt ggagggaagg     1080

gaagggcttt tctccacaca agggcagaga gtccgtctag atttcttgct gtcctgccag     1140

ctctgcccat gcctgaggtg gtcctacctc tcacgggcac cctagctgct gacagccctt     1200

tgtggccgcc gtccccatcc cctgccctca gcacacacat ctgcacacac gcagctttgt     1260

tctcacctct acctgtcatt ccagcatccc tgcctcttgt cacaaactgc cccagcaaga     1320

atttgaggtt ctgacaacag tacccatccc ccacagtacc ccttcagctc agtttctaga     1380

aagctccctt ttctttgaaa tctgcatgtt gaattgaact ttgtgatttt attttttgtt     1440

tcaaaaaagt ttaagaaaat ggaaatgggc aacagtgagt gaagacatat tttagcactg     1500

aatagaatat ttttaaaatt aaactatttg aaatatgtcc aaaaaaaaaa aaaaaaaa       1558


<210> 159
<211> 145
<212> PRT
<213> Homo sapiens

<400> 159
Met Ser Gly Arg Ser Val Arg Ala Glu Thr Arg Ser Arg Ala Lys Asp 
1               5                   10                  15      


Asp Ile Lys Lys Val Met Ala Ala Ile Glu Lys Val Arg Lys Trp Glu 
            20                  25                  30          


Lys Lys Trp Val Thr Val Gly Asp Thr Ser Leu Arg Ile Phe Lys Trp 
        35                  40                  45              


Val Pro Val Thr Asp Ser Lys Glu Lys Glu Lys Ser Lys Ser Asn Ser 
    50                  55                  60                  


Ser Ala Ala Arg Glu Pro Asn Gly Phe Pro Ser Asp Ala Ser Ala Asn 
65                  70                  75                  80  


Ser Ser Leu Leu Leu Glu Phe Gln Glu Pro Ser Leu Pro Ser Ser Glu 
                85                  90                  95      


Val Ala Asp Glu Pro Pro Thr Leu Thr Lys Glu Glu Pro Val Pro Leu 
            100                 105                 110         


Glu Thr Gln Val Val Glu Glu Glu Glu Asp Ser Gly Ala Pro Pro Leu 
        115                 120                 125             


Lys Arg Phe Cys Val Asp Gln Pro Thr Val Pro Gln Thr Ala Ser Glu 
    130                 135                 140                 


Ser 
145 


<210> 160
<211> 1851
<212> DNA
<213> Homo sapiens

<400> 160
gcgggcgggt gcgcgcgctt tctcgcgcac gcgcgcacgg agggggcgac ggccgctgtg       60

acgctgcggc ggcggcgggc gggcggcggc gcgtgaggcg cgcgatcccc ggtgtcttgg      120

gagcagtgcc ccggcccccg ccgctcccgc cgccgccatg tcgggccggt cggtccgggc      180

ggagacccgc agccgggcca aggacgacat caagaaggtg atggcggcca tcgagaaagt      240

gcggaaatga cggaatctcg ctctgtcacc caggctggag tgcattggcg caatctcggc      300

tcactgcaac ctctgcctct caggttcaag caattctcct gcctcagcct cctgagtagc      360

tgggactaca gggagaagaa gtgggtgact gtgggtgaca cgtccctgag gatatttaag      420

tgggttcctg tgacagacag caaggagaaa gaaaagtcaa aatcgaacag ttcagcagcc      480

cgagaaccta atggctttcc ttctgatgcc tcagccaatt cctctctcct tcttgaattc      540

caggacgaaa acagcaacca gagttccgtg tctgacgtct atcagcttaa ggtggacagc      600

agcaccaact caagccccag cccccagcag agtgagtccc tgagcccagc acacacctcc      660

gacttccgca cggatgactc ccagccccca acgctgggcc aggagatcct ggaggagccc      720

tccctgccct cctcggaagt tgctgatgaa cctcctaccc tcaccaagga agaaccagtt      780

ccactagaga cacaggtcgt tgaggaagag gaagactcag gtgccccgcc cctgaagcgc      840

ttctgtgtgg accaacccac agtgccgcag acggcgtcag aaagctagca ccatcccggc      900

cctccgcctc ctggccctgc ctctatttat tgcattctgg ttctggccgc gccgcgttgc      960

tggggtaagg gcaagcactg gggtcaagag cctgcacaca tgagccttcc gggctggaag     1020

gctggcgtag gacttggggc tgtagcatca tcttcctgac cctggcacct gtgtctactt     1080

gctcccgaga agaggagcgc tcatgtcttt tttgcacccc aagttggctg gagcatcggc     1140

caccccaaga ttcatctgtg acctccaggc agcagtctct gctccagaat ctctggacgg     1200

agctgctggc agcttctgcg agaagagaga gatgtggaag gcaccttcta gaagagagcg     1260

tgcctcaggt tacttgaact tgaacggaga ctgtagactc ccggactttc ccctaggact     1320

gggggccctg taggctgctg ttggaggact gggtagagac attggaggga agggaagggc     1380

ttttctccac acaagggcag agagtccgtc tagatttctt gctgtcctgc cagctctgcc     1440

catgcctgag gtggtcctac ctctcacggg caccctagct gctgacagcc ctttgtggcc     1500

gccgtcccca tcccctgccc tcagcacaca catctgcaca cacgcagctt tgttctcacc     1560

tctacctgtc attccagcat ccctgcctct tgtcacaaac tgccccagca agaatttgag     1620

gttctgacaa cagtacccat cccccacagt accccttcag ctcagtttct agaaagctcc     1680

cttttctttg aaatctgcat gttgaattga actttgtgat tttatttttt gtttcaaaaa     1740

agtttaagaa aatggaaatg ggcaacagtg agtgaagaca tattttagca ctgaatagaa     1800

tatttttaaa attaaactat ttgaaatatg tccaaaaaaa aaaaaaaaaa a              1851


<210> 161
<211> 213
<212> PRT
<213> Homo sapiens

<400> 161
Met Thr Glu Ser Arg Ser Val Thr Gln Ala Gly Val His Trp Arg Asn 
1               5                   10                  15      


Leu Gly Ser Leu Gln Pro Leu Pro Leu Arg Phe Lys Gln Phe Ser Cys 
            20                  25                  30          


Leu Ser Leu Leu Ser Ser Trp Asp Tyr Arg Glu Lys Lys Trp Val Thr 
        35                  40                  45              


Val Gly Asp Thr Ser Leu Arg Ile Phe Lys Trp Val Pro Val Thr Asp 
    50                  55                  60                  


Ser Lys Glu Lys Glu Lys Ser Lys Ser Asn Ser Ser Ala Ala Arg Glu 
65                  70                  75                  80  


Pro Asn Gly Phe Pro Ser Asp Ala Ser Ala Asn Ser Ser Leu Leu Leu 
                85                  90                  95      


Glu Phe Gln Asp Glu Asn Ser Asn Gln Ser Ser Val Ser Asp Val Tyr 
            100                 105                 110         


Gln Leu Lys Val Asp Ser Ser Thr Asn Ser Ser Pro Ser Pro Gln Gln 
        115                 120                 125             


Ser Glu Ser Leu Ser Pro Ala His Thr Ser Asp Phe Arg Thr Asp Asp 
    130                 135                 140                 


Ser Gln Pro Pro Thr Leu Gly Gln Glu Ile Leu Glu Glu Pro Ser Leu 
145                 150                 155                 160 


Pro Ser Ser Glu Val Ala Asp Glu Pro Pro Thr Leu Thr Lys Glu Glu 
                165                 170                 175     


Pro Val Pro Leu Glu Thr Gln Val Val Glu Glu Glu Glu Asp Ser Gly 
            180                 185                 190         


Ala Pro Pro Leu Lys Arg Phe Cys Val Asp Gln Pro Thr Val Pro Gln 
        195                 200                 205             


Thr Ala Ser Glu Ser 
    210             


<210> 162
<211> 1678
<212> DNA
<213> Mus musculus

<400> 162
acgcgcgcac ggaggggggg cgacggccgc ggtgacgtgc tgcggtggca gcgggtggac       60

ggcgacgcgt gaggcgcgtg atatcccgcg tcttgggagc actgtcccgg cccccagcca      120

ctccccgccg ccgccatgtc cggccgttcg gtccgggccg agacccgtag ccgggctaaa      180

gatgacatca agaaggtgat ggcggccatc gagaaagtgc ggaaatggga gaagaaatgg      240

gtgactgtgg gtgatacctc cctgaggata ttcaaatggg tgcctgtgac agatagcaag      300

gagaaagaaa agtcaaaatc gaataataca gcagcccggg aacctaatgg ctttccctct      360

gacgcctcag ccaattcctc cctcctcctt gaattccagg atgagaacag caaccagagc      420

tctgtgtcgg atgtctatca actcaaggtg gacagcagca ccaactcaag tcccagcccc      480

cagcagagcg agtccctgag cccagcacac acctcagact tccgcactga tgactcccag      540

ccccccacat tgggccagga gatcctggag gaaccttcgc tgcctgcatc tgaagttgca      600

gatgaacctc ccacactcac aaaggaagag ccagtgccgg tggagacaca gaccactgag      660

gaagaggagg actctggtgc tccgcccttg aagagattct gtgtggacca acctgtagta      720

ccgcagacca cgtcggaaag ctagcaccgt cctggcccct cgcctcctgg cccctgcctc      780

tatttattgc attctggtct ggccgagctc tgatgctggg gtccgggcaa gcactagggt      840

ccagagcctg tgcgtgggag ccctctgggc tagaaggctg atggagggcg tggggtcgtc      900

gcaccatctt cttgttcctg acacttgtgt ctgcttgctc ttgagcaaag gagcgctcac      960

atcttttctg tagcccaagt aggccagagc atcagggttc atttctcacc tccagaacca     1020

ctgcacggag ctgctggcgc cgccacgggg agaaaggtgt ggaaggcgcc cacctgagag     1080

aagagtgcct aggattactt gaattgaatg gagactgtgg agtatggact ttgccacagg     1140

gccaggccct gcaggctgct gctgggagag ggactgaccg gtagagatgt ggagaacacc     1200

ggagagaggc tcttccggga cggaggggct ttcgccacct ttgggcagaa gacccatggg     1260

agatgcatcc tgtgcctgag gcagacctgc ctctgttgga tgccccagct gctcccagcc     1320

ctgtgcctgc cagaaccttc tgctgcatcc tcacactcac taagcacacc tgaagctttc     1380

tattcacccg tcctttcatt ccaacgtccc cacctcctcc tgcagaaaac cccagccatg     1440

attggaggtt ctgaccacag tacctgcccc agtactcctt cagctcagac tttctagaaa     1500

gttccttttt ctttaaaatc tgcatgttta attaaacttt atgattttat tttttgtctg     1560

aaaaaagaaa agtttaagaa aatggaaatg ggtaacagca agtgaagacc tattttagca     1620

ctgaatagag tatttttaaa attaaacttt gaaatatgtc ttgttaaaaa aaaaaaaa       1678


<210> 163
<211> 202
<212> PRT
<213> Mus musculus

<400> 163
Met Ser Gly Arg Ser Val Arg Ala Glu Thr Arg Ser Arg Ala Lys Asp 
1               5                   10                  15      


Asp Ile Lys Lys Val Met Ala Ala Ile Glu Lys Val Arg Lys Trp Glu 
            20                  25                  30          


Lys Lys Trp Val Thr Val Gly Asp Thr Ser Leu Arg Ile Phe Lys Trp 
        35                  40                  45              


Val Pro Val Thr Asp Ser Lys Glu Lys Glu Lys Ser Lys Ser Asn Asn 
    50                  55                  60                  


Thr Ala Ala Arg Glu Pro Asn Gly Phe Pro Ser Asp Ala Ser Ala Asn 
65                  70                  75                  80  


Ser Ser Leu Leu Leu Glu Phe Gln Asp Glu Asn Ser Asn Gln Ser Ser 
                85                  90                  95      


Val Ser Asp Val Tyr Gln Leu Lys Val Asp Ser Ser Thr Asn Ser Ser 
            100                 105                 110         


Pro Ser Pro Gln Gln Ser Glu Ser Leu Ser Pro Ala His Thr Ser Asp 
        115                 120                 125             


Phe Arg Thr Asp Asp Ser Gln Pro Pro Thr Leu Gly Gln Glu Ile Leu 
    130                 135                 140                 


Glu Glu Pro Ser Leu Pro Ala Ser Glu Val Ala Asp Glu Pro Pro Thr 
145                 150                 155                 160 


Leu Thr Lys Glu Glu Pro Val Pro Val Glu Thr Gln Thr Thr Glu Glu 
                165                 170                 175     


Glu Glu Asp Ser Gly Ala Pro Pro Leu Lys Arg Phe Cys Val Asp Gln 
            180                 185                 190         


Pro Val Val Pro Gln Thr Thr Ser Glu Ser 
        195                 200         


<210> 164
<211> 1998
<212> DNA
<213> Homo sapiens

<400> 164
tccgtcccca actcgcgcgt ccgtccccaa ctcccgctct cggcggcggg cagggggcgc       60

tgagcgtcca ggcgctccaa gggggcgggc ccgggtcggg gcggggccgg ccgggcttcc      120

aggcctgggc tctggccgcc cgcgccaccg ggccgctccg gggacaggcc ggggcggggc      180

gcggcggcag gaaacggggc ggggacttgc ggaggcgttg gggacgagag agggcgcggc      240

caactccagg ggggacggca ggccgagagc gcggcgcccg ggcctggcgc ggagcctgag      300

cccgccggac gggaggcggc cccgccgcgg gctcggcccc ggccccagcc ccgccagcat      360

ggccggccgg actgtacggg ccgagacccg gagccgggcc aaggatgaca tcaagaaggt      420

gatggcgacc atcgagaagg tccggagatg ggagaagcga tgggtgactg tgggcgacac      480

ttcccttcgt atcttcaagt gggtgccagt ggtggatccc caggaggagg agcgaaggcg      540

ggcaggtggc ggggcagaga gatcccgtgg ccgggaacgt cggggcaggg gcgccagtcc      600

ccgagggggt ggccctctca tcctgctgga tcttaatgat gagaacagca accagagttt      660

ccattcggaa ggttccctgc aaaagggcac agagcccagt cctgggggca ccccccagcc      720

cagccgccct gtgtcacctg ccggaccccc agaaggggtc cctgaggagg ctcagccccc      780

acggctgggc caagagagag atcccggggg cataactgct ggcagcaccg acgaaccccc      840

aatgctgacc aaggaggagc ctgttccaga actgctggaa gctgaggatt cgggagtgag      900

aatgacgagg agagcccttc acgagaaggg gctgaagaca gagcccctca ggaggctcct      960

gcccaggagg ggcctccgga caaatgtccg gcccagttcc atggcggtgc cggacaccag     1020

agctcccggg ggaggcagca aggccccgag ggcacccaga acaatccccc agggtaaggg     1080

gaggtgagtg ggctccccaa gcaagccaag acccctaaag cctcccttgg ctgccccaag     1140

atccagccac tacctgtgcc ccgagggcgg aaagagcttc ccagctcacc caccgcggta     1200

acatcggagg gcgagcggcc ccacacctgc ccgaacctaa ggccacagca cccatctggc     1260

tcgccactgg cgcccgaatg catgggaagg gcttagggca gaactcggac cacatccagt     1320

gcctgaggcc gccttgctag aggcctaggg gaggggtgca ctgggctgcc tcgcccacct     1380

cctcacgcac ccatgcggcc accctcccag cggtctgagt gtgccatgcg aggcgcctgc     1440

caccccggga gaggcgccga gtcccgagtc ctgccggcac tgagcctccg ggtccacagc     1500

gggcaagggc cgtggcgggg acaagcgcag gggacccgcc ggcctcccgc cttctgcagc     1560

accacgagat gcccacgtgg cacctggacg tccatgcata tgttgaggcc cgtgcacgcg     1620

cagagacccc agcgcagaag ccgccccgca cgccagggct tatgtatgcc agcgctggga     1680

gacctccagc gcccgaggac atacggcaag tggttccacc agggtgtcag cctagcaggc     1740

caacctggga acccatgtgg acaagcggcc tttcagccca ggcgcccgcc tcgggtggag     1800

gcgtggagac ttctggcgca gccctgagct ggtggcctaa cctacctgga aaatcctagc     1860

ccgagaagca gcgcgagtga gccttttggg tggttccaag gcccttcacc aagctctcac     1920

ttcctgactt caccgttggg tctgttgtac taggaaataa taacgcctcc catttatcaa     1980

gggtttactc tgtaaaaa                                                   1998


<210> 165
<211> 242
<212> PRT
<213> Homo sapiens

<400> 165
Met Ala Gly Arg Thr Val Arg Ala Glu Thr Arg Ser Arg Ala Lys Asp 
1               5                   10                  15      


Asp Ile Lys Lys Val Met Ala Thr Ile Glu Lys Val Arg Arg Trp Glu 
            20                  25                  30          


Lys Arg Trp Val Thr Val Gly Asp Thr Ser Leu Arg Ile Phe Lys Trp 
        35                  40                  45              


Val Pro Val Val Asp Pro Gln Glu Glu Glu Arg Arg Arg Ala Gly Gly 
    50                  55                  60                  


Gly Ala Glu Arg Ser Arg Gly Arg Glu Arg Arg Gly Arg Gly Ala Ser 
65                  70                  75                  80  


Pro Arg Gly Gly Gly Pro Leu Ile Leu Leu Asp Leu Asn Asp Glu Asn 
                85                  90                  95      


Ser Asn Gln Ser Phe His Ser Glu Gly Ser Leu Gln Lys Gly Thr Glu 
            100                 105                 110         


Pro Ser Pro Gly Gly Thr Pro Gln Pro Ser Arg Pro Val Ser Pro Ala 
        115                 120                 125             


Gly Pro Pro Glu Gly Val Pro Glu Glu Ala Gln Pro Pro Arg Leu Gly 
    130                 135                 140                 


Gln Glu Arg Asp Pro Gly Gly Ile Thr Ala Gly Ser Thr Asp Glu Pro 
145                 150                 155                 160 


Pro Met Leu Thr Lys Glu Glu Pro Val Pro Glu Leu Leu Glu Ala Glu 
                165                 170                 175     


Asp Ser Gly Val Arg Met Thr Arg Arg Ala Leu His Glu Lys Gly Leu 
            180                 185                 190         


Lys Thr Glu Pro Leu Arg Arg Leu Leu Pro Arg Arg Gly Leu Arg Thr 
        195                 200                 205             


Asn Val Arg Pro Ser Ser Met Ala Val Pro Asp Thr Arg Ala Pro Gly 
    210                 215                 220                 


Gly Gly Ser Lys Ala Pro Arg Ala Pro Arg Thr Ile Pro Gln Gly Lys 
225                 230                 235                 240 


Gly Arg 
        


<210> 166
<211> 1101
<212> DNA
<213> Homo sapiens

<400> 166
tccgtcccca actcgcgcgt ccgtccccaa ctcccgctct cggcggcggg cagggggcgc       60

tgagcgtcca ggcgctccaa gggggcgggc ccgggtcggg gcggggccgg ccgggcttcc      120

aggcctgggc tctggccgcc cgcgccaccg ggccgctccg gggacaggcc ggggcggggc      180

gcggcggcag gaaacggggc ggggacttgc ggaggcgttg gggacgagag agggcgcggc      240

caactccagg ggggacggca ggccgagagc gcggcgcccg ggcctggcgc ggagcctgag      300

cccgccggac gggaggcggc cccgccgcgg gctcggcccc ggccccagcc ccgccagcat      360

ggccggccgg actgtacggg ccgagacccg gagccgggcc aaggatgaca tcaagaaggt      420

gatggcgacc atcgagaagg tccggagatg ggagaagcga tgggtgactg tgggcgacac      480

ttcccttcgt atcttcaagt gggtgccagt ggtggatccc caggaggagg agcgaaggcg      540

ggcaggtggc ggggcagaga gatcccgtgg ccgggaacgt cggggcaggg gcgccagtcc      600

ccgagggggt ggccctctca tcctgctgga tcttaatgat gagaacagca accagagttt      660

ccattcggaa ggttccctgc aaaagggcac agagcccagt cctgggggca ccccccagcc      720

cagccgccct gtgtcacctg ccggaccccc agaaggggtc cctgaggagg ctcagccccc      780

acggctgggc caagagagag atcccggggg cataactgct ggcagcaccg acgaaccccc      840

aatgctgacc aaggaggagc ctgttccaga actgctggaa gctgaggccc ccgaagctta      900

ccctgtcttt gagccagtgc cacctgtccc tgaggcagcc cagggtgaca cagaggactc      960

ggagggtgcc cccccactca agcgcatctg cccaaatgcc cctgacccct gagaagccgg     1020

cctgcctgtc ctgttgcccc aggggcccct ttggcttttt acaaataaag acccttttgt     1080

aaaaaaaaaa aaaaaaaaaa a                                               1101


<210> 167
<211> 217
<212> PRT
<213> Homo sapiens

<400> 167
Met Ala Gly Arg Thr Val Arg Ala Glu Thr Arg Ser Arg Ala Lys Asp 
1               5                   10                  15      


Asp Ile Lys Lys Val Met Ala Thr Ile Glu Lys Val Arg Arg Trp Glu 
            20                  25                  30          


Lys Arg Trp Val Thr Val Gly Asp Thr Ser Leu Arg Ile Phe Lys Trp 
        35                  40                  45              


Val Pro Val Val Asp Pro Gln Glu Glu Glu Arg Arg Arg Ala Gly Gly 
    50                  55                  60                  


Gly Ala Glu Arg Ser Arg Gly Arg Glu Arg Arg Gly Arg Gly Ala Ser 
65                  70                  75                  80  


Pro Arg Gly Gly Gly Pro Leu Ile Leu Leu Asp Leu Asn Asp Glu Asn 
                85                  90                  95      


Ser Asn Gln Ser Phe His Ser Glu Gly Ser Leu Gln Lys Gly Thr Glu 
            100                 105                 110         


Pro Ser Pro Gly Gly Thr Pro Gln Pro Ser Arg Pro Val Ser Pro Ala 
        115                 120                 125             


Gly Pro Pro Glu Gly Val Pro Glu Glu Ala Gln Pro Pro Arg Leu Gly 
    130                 135                 140                 


Gln Glu Arg Asp Pro Gly Gly Ile Thr Ala Gly Ser Thr Asp Glu Pro 
145                 150                 155                 160 


Pro Met Leu Thr Lys Glu Glu Pro Val Pro Glu Leu Leu Glu Ala Glu 
                165                 170                 175     


Ala Pro Glu Ala Tyr Pro Val Phe Glu Pro Val Pro Pro Val Pro Glu 
            180                 185                 190         


Ala Ala Gln Gly Asp Thr Glu Asp Ser Glu Gly Ala Pro Pro Leu Lys 
        195                 200                 205             


Arg Ile Cys Pro Asn Ala Pro Asp Pro 
    210                 215         


<210> 168
<211> 6360
<212> DNA
<213> Mus musculus

<400> 168
ggccggggct ctagcagccc gcgccgcccg ggccgctccg gggacgggcc ggggcggggc       60

gcggtcttag gaagccaggc ggggacgcgc ggaggcgttg gggagcgagg gagggcgcgg      120

ccaactcccg gagggacggc aggccgaaag agcggcgctg gggcctggcg ctcagcctga      180

gatcgccgga ccacaggccg ccccgccacg ggctctgtcc cggccccagc cccgccagca      240

tggccggccg gaccgtgcgg gccgagaccc ggagccgggc caaagatgac atcaagaagg      300

tgatggcgac catcgagaag gtccggagat gggagaagcg ctgggtgact gtgggagaca      360

cttcccttcg aatcttcaag tgggtgcctg tggtggatcc ccaggaggag gagaggcggc      420

gggcaggagg cggggcagag agatcccgtg gccgggagag acgtggtagg ggcaccagtc      480

ccagaggggg aggccccctc atcctactgg atctcaatga tgagaacagc aaccagagtt      540

tccattctga aggttcattg caaaagggtg ctgagcccag ccctgggggg acgccccagc      600

ccagccgccc tggatcacca actggacccc cagaagtgat tactgaagat actcagcccc      660

cacaattggg tcaggagaga gatccagggg ggacacctgc aggcggtact gatgaacccc      720

caaagctgac caaggaggag cctgttccag aattgctaga agctgaggat tccggcgtga      780

gactcaccag gagagccctt caagagaaag gcctgaaaac cgagcccctc aggaggcttc      840

tccccaggag aggcctccgg acaaattctc ggccaacttc cacggttccg gaacccagag      900

ctcccggaag tgggagcaag gcccagaggg cacccaggac gataccacaa gggaagggga      960

ggtgagcggg ttccaccaca caaggggagg cccttaggtc ttccttagct gcctcaagat     1020

ccagtcattt acccacaccg tttaagggtg gagagggctt tggagctggg cacccgcagc     1080

cagcaatgga ggtcggcagc cagctctctg cttgtccctg tccctaaatt atggatccat     1140

cctgcttgct gtgggtccaa aactactggg ccagagcagg tcccagacag ggaatgtctg     1200

gggacatctc taggtgatgc ctagaagcaa cttgaataca caaaatggtg gatcctatgc     1260

caacttggtc acctcctcac acacttaggg cagccatcca ccaaagggcc aggcatggcc     1320

cctggaggtg accttcgacc tttggaacta cagtatctac actggtgagg ggccctacca     1380

gcaagacttg agcagcgagc aacccctgaa gcactgggca aaaggtaatg ccacagcttg     1440

tgaatggtgt gaagattcaa ttgcccgtgt gtagagacac cactccagca agcacctggc     1500

agcctcaccc gcttccacga gcctatggac tctgggcctg ctaattaacc cttggctcca     1560

gaagacatgt gccaaccagg gtgccaacct tgcctcaggt caatcgaggg gtgcacatgg     1620

cccagtgacc tttcagacca ggccacagcc tcctgcccca ggaatggatg gagacatgtg     1680

gtccagcact gccaaatcta cctggaaact acccactttg agaaactcat ggcagatgag     1740

ccatctgagt gattccaagg gctttcatca acctcttgcc tccgacttga caactcactt     1800

ggccaggagg tagtgtctcc tgtaccacag agagctaact gtactacata ttgcaacttg     1860

tgggacttat ttaatgcagc actcctgtca tagatcctgt tactttcaca ttttacagat     1920

atagaaaaca agcaaccagg aggttaaaga gcttgcccca agtcacacag cctgtctgtg     1980

gcagagccag cattcacatc cagtctaccc acctgactcc acagtccctg ctagtgtacc     2040

actttttgtg ctgggcatgc aggtgggctg cagctgtgag ctttgttgag gcgttcattg     2100

aaggaacatc catttttctc agtggcaaat tacaaaggac ttttaatttt aactttcttc     2160

tgcctgacct accttccttc cttccttcct tccttccttc cttccttcct tccttccttc     2220

cttccttcct tcctttcttc ctctgctggc catgaaccca ctagaccagg ccagtcttga     2280

actcacagag gtctgtctat ctctgcctct ccagtgctgg gattaaaggt gagcgacacc     2340

atacccagct taggccttct ttgtttgttt gtttgttgtt ttttgagtaa taaggtaagc     2400

agatgttctg tgtccataac tgagatgaca tggacattga gtggtaaggg acttgagctc     2460

agcccctggg tccctcagat tcctctctgg agtgccattg atacaggaag catcatctag     2520

gcccagctcc tgattggcga cttcccagaa gccatgggct gtcatgccaa gtgactgggg     2580

aacttcaagt aacaaacatt tattaattag acttctgaac taccaatggg gcagaagttt     2640

tcacgtttca aacacagata ctagttttca agattcagaa atgaaacata ggaattctgg     2700

ggaggtccag aaagtcctac tttgtatttt tcataactct ctgtatctta aaagctaaga     2760

aactcacagt tcatcgtagt ttaaaagagc tgcaagcctt aaatattcaa aaggtagaaa     2820

ctgccagtgt gtgtcactgg gtagtagttg aataacaaaa tgtttacgga tccaattaga     2880

ttcatggtac tccagagtca tgagttgaaa tcgcggatat aaagacttat ttccaatgca     2940

tcatttctca gaacaccctg ggatttgtat aaaacacacg atgcatgtga acgcattcat     3000

gtttatctta tttctgagaa tcattctaca ggcgggggag cacgcataca tttttaatgt     3060

cagggctaca gaagactggc ctggcacggc tcccctcagt tcttggttcc caaattctaa     3120

ggatgtctgc cttcgtttca tgtgtcagcc tttcctgctc tcggacctga cacagtggct     3180

ccgtacagcg aggactcctc tgtgctgatg aacttcggct gttagaggac tgttagtatg     3240

tttcctgttt cgccaattta tttgctgatt ggttttgtga ttcaaaaaac aaacaagcaa     3300

gcaaacaaac aaaaacaaaa gcagggacca ggcgtggtgg cgcacgcctt taatcttgga     3360

ggcagaggca ggcggatttc tgagttcgag gccaacctga tctacaaagt gagttccagg     3420

acagccaggg ctatacagag aaaccctgtc tcaaaaacaa acaaacaaaa acaaacaaaa     3480

aaacaaaagc agacaaaatc accaccagca gcagcaacaa tcccaggttt cccaataatg     3540

tcagcaagga attctgaaca gacaaagtcc gtggggctga gcagggacgg tgaataagtg     3600

agctcgtgtt tatgaagccc agtgatctgc tccttgcagc cagaacgctc cagctcagcc     3660

aggccctggc acgagccctc ggctgaagca ctcacctctg agcttcagtt tagtgagtag     3720

catcctccct agaaagtaat attcttgctt catacggtga tatggtggaa gggttaccag     3780

catggctttg gagtcagaca gactgtggtt caaatcttag ctacacgact ttctacctct     3840

ttgatttggg gcaagttcta accgctggct ttttctcttc tgtaaaatga ggacatggaa     3900

tctatttcac agggctgtgg cttcagtgag atcacatatg acccgcttaa gtcaaagcgg     3960

gtccacggta tgtgtttgat cccacgtagg cattacccgc tgtatctacc tcacagggca     4020

gttgtgagga tgaagggtag agggaaatgc tttccaaact gtgaagtgat ctgtgtttac     4080

ctctctcctc tggagatgga gagataggaa gttgctgtca gacactagtg ggatgcccat     4140

ggagagggcc tagtatgctt ctgtgcacac agtgtggctg ggctgaaggg gaggtgctgt     4200

gttgtgcagt ggtgcacagc gggggcgtgc cctccggtga gggttgctgc actgaagtgg     4260

ggaagttcag tgcctatggc tacactgttg ggagcaggga gagcgcaggt cctatcttaa     4320

gaaggatgct agatgggggc taaagtagat gagtgtttgc ctagcatgag caagggccat     4380

ggatttcgta tctagcacct caggaaaaac acaacaaaca aacaaacaaa caaacccctc     4440

ttcttgttta aagattctgg ataaagaaca gtgttgtgaa cgtgtgtatc cactgtttgt     4500

ctttttaaat acaactcaaa tagcaggaag gcctgtgtgc acaagaggtg acaagtgact     4560

gcaagtgttt ccatcgctgg cagccatgca ccctcctacc acgagtacag atttcattct     4620

ggagtgtgca gaccaaatgc aggtcagagg gccctcccgg ggcaactcgc caagatcctg     4680

accaaagcct agcctcacaa agtaatccct agcccagtta gcagatcagg ggttggggct     4740

tgggaacgtc atgtccaatg tccaaggctg cacaggtcct gtggggacag aatccaagcc     4800

cttcacctgg attggggttc ctccgcctgc cagtctcaga tctctgatct tgaacaagga     4860

tagcatgcag aagagtaagg ttccatgcct aagtgacctc ctctggacct cagacgcagt     4920

tcttgctcct gacctcatgc ctcgtctcca gacatcactc cccagcttag cccttaggtc     4980

aggctcctct gggcaccatc cttagattca acccaaagga gggtcctctc attctaacca     5040

gactgtctct ccaaatacca ccctagtcag ctccttggct tctcagtgtc cccttggaga     5100

acatggggta taggttccca gctagttcag tggcattcca cagcccatct cttgtgaggt     5160

cccactcctt aacaatggtc tttcagtttc aaacgcatgc ggccagcggg cagtctaggg     5220

acccttcaaa gtcaatgctt cttgattaaa ttatcgagac taatgtttaa ctttgagata     5280

cgttttctga gagttgctaa ccggttggag atgaacttag agaatagggt tcaccttttt     5340

cgtctgtcag cgggttatcg agtgcccagt ggtgtgccag attcagcagc tggtgcagga     5400

gatacattcg tgagcaaaac agatctgagc cctgacttcg ggaggcctcc tcctaacaac     5460

tagggcagat ataaccagtg ttccctgaat acaaacgcct agcctggcat ggtggcacac     5520

acctatgatg tcagccctta ggagccggag gtaagaagat caggagttca gctatctttg     5580

gccaacctgg gctacataag accgtgtctt aaaaaaaaaa aaaaaaatcc aaacaaaata     5640

cacactataa ctgtgagaaa tgttgtgaag agaaaggtcc aaatgcagtg aaagagctca     5700

gtaaaaaaag tgtggggtgt gttaggacag tgacaacatg tgcccgtatg tggagaagag     5760

aatcctgggt aatgggagga gcttactgta ttggaatcgg cagcagcagt gaggtctgct     5820

gctggacgga gcctgccccc caggctgggt ggggaaggtg tcacggacct tgcagaccac     5880

ggtaaggaac ttgcattctg gtgtttaact ttttatttgg agaccatttc aaagtgactg     5940

gaaccttatg agagtggcac aaaagatgtc tgcatacttt ggctgcagcc tccccgactg     6000

acctgtaaac gttctgttcc ccgagtcacc acccgtgtct ccctgtgatg tgtactcata     6060

gcctgtagtc cgaactctga gaatgagttg catacattgt gtctgtttac acttaaaaca     6120

cagtggagac cccctacagt aatgcctcgc ccgcctccgc ctgccacact gggtttatcg     6180

ctggttggtg gctccacact gtttgttggt cgtctctcta gtcaccttca ttagcatctt     6240

ccctttagga caagtcacgt ctgcgaatga tgtggaccat gcgttgtgct ttcttgctcg     6300

tatcttttaa tgtggcgtag tttctttcct ctctgtttga atagactatt tctccttttg     6360


<210> 169
<211> 241
<212> PRT
<213> Mus musculus

<400> 169
Met Ala Gly Arg Thr Val Arg Ala Glu Thr Arg Ser Arg Ala Lys Asp 
1               5                   10                  15      


Asp Ile Lys Lys Val Met Ala Thr Ile Glu Lys Val Arg Arg Trp Glu 
            20                  25                  30          


Lys Arg Trp Val Thr Val Gly Asp Thr Ser Leu Arg Ile Phe Lys Trp 
        35                  40                  45              


Val Pro Val Val Asp Pro Gln Glu Glu Glu Arg Arg Arg Ala Gly Gly 
    50                  55                  60                  


Gly Ala Glu Arg Ser Arg Gly Arg Glu Arg Arg Gly Arg Gly Thr Ser 
65                  70                  75                  80  


Pro Arg Gly Gly Gly Pro Leu Ile Leu Leu Asp Leu Asn Asp Glu Asn 
                85                  90                  95      


Ser Asn Gln Ser Phe His Ser Glu Gly Ser Leu Gln Lys Gly Ala Glu 
            100                 105                 110         


Pro Ser Pro Gly Gly Thr Pro Gln Pro Ser Arg Pro Gly Ser Pro Thr 
        115                 120                 125             


Gly Pro Pro Glu Val Ile Thr Glu Asp Thr Gln Pro Pro Gln Leu Gly 
    130                 135                 140                 


Gln Glu Arg Asp Pro Gly Gly Thr Pro Ala Gly Gly Thr Asp Glu Pro 
145                 150                 155                 160 


Pro Lys Leu Thr Lys Glu Glu Pro Val Pro Glu Leu Leu Glu Ala Glu 
                165                 170                 175     


Asp Ser Gly Val Arg Leu Thr Arg Arg Ala Leu Gln Glu Lys Gly Leu 
            180                 185                 190         


Lys Thr Glu Pro Leu Arg Arg Leu Leu Pro Arg Arg Gly Leu Arg Thr 
        195                 200                 205             


Asn Ser Arg Pro Thr Ser Thr Val Pro Glu Pro Arg Ala Pro Gly Ser 
    210                 215                 220                 


Gly Ser Lys Ala Gln Arg Ala Pro Arg Thr Ile Pro Gln Gly Lys Gly 
225                 230                 235                 240 


Arg 
    


<210> 170
<211> 981
<212> DNA
<213> Mus musculus

<400> 170
ggccggggct ctagcagccc gcgccgcccg ggccgctccg gggacgggcc ggggcggggc       60

gcggtcttag gaagccaggc ggggacgcgc ggaggcgttg gggagcgagg gagggcgcgg      120

ccaactcccg gagggacggc aggccgaaag agcggcgctg gggcctggcg ctcagcctga      180

gatcgccgga ccacaggccg ccccgccacg ggctctgtcc cggccccagc cccgccagca      240

tggccggccg gaccgtgcgg gccgagaccc ggagccgggc caaagatgac atcaagaagg      300

tgatggcgac catcgagaag gtccggagat gggagaagcg ctgggtgact gtgggagaca      360

cttcccttcg aatcttcaag tgggtgcctg tggtggatcc ccaggaggag gagaggcggc      420

gggcaggagg cggggcagag agatcccgtg gccgggagag acgtggtagg ggcaccagtc      480

ccagaggggg aggccccctc atcctactgg atctcaatga tgagaacagc aaccagagtt      540

tccattctga aggttcattg caaaagggtg ctgagcccag ccctgggggg acgccccagc      600

ccagccgccc tggatcacca actggacccc cagaagtgat tactgaagat actcagcccc      660

cacaattggg tcaggagaga gatccagggg ggacacctgc aggcggtact gatgaacccc      720

caaagctgac caaggaggag cctgttccag aattgctaga agctgaggcc cccgaagctt      780

accctgtctt tgagccagtg ccatctgtcc ctgaggcagc ccagggtgac acagaggact      840

cggagggcgc ccccccactc aagcgcatct gtccaaatgc ccctgacccc tgagaagccg      900

cctgcctcct gtcctgttgc tccaggggcc cctttggctt tttataaata aagacccttt      960

tgtaaaaaaa aaaaaaaaaa a                                                981


<210> 171
<211> 217
<212> PRT
<213> Mus musculus

<400> 171
Met Ala Gly Arg Thr Val Arg Ala Glu Thr Arg Ser Arg Ala Lys Asp 
1               5                   10                  15      


Asp Ile Lys Lys Val Met Ala Thr Ile Glu Lys Val Arg Arg Trp Glu 
            20                  25                  30          


Lys Arg Trp Val Thr Val Gly Asp Thr Ser Leu Arg Ile Phe Lys Trp 
        35                  40                  45              


Val Pro Val Val Asp Pro Gln Glu Glu Glu Arg Arg Arg Ala Gly Gly 
    50                  55                  60                  


Gly Ala Glu Arg Ser Arg Gly Arg Glu Arg Arg Gly Arg Gly Thr Ser 
65                  70                  75                  80  


Pro Arg Gly Gly Gly Pro Leu Ile Leu Leu Asp Leu Asn Asp Glu Asn 
                85                  90                  95      


Ser Asn Gln Ser Phe His Ser Glu Gly Ser Leu Gln Lys Gly Ala Glu 
            100                 105                 110         


Pro Ser Pro Gly Gly Thr Pro Gln Pro Ser Arg Pro Gly Ser Pro Thr 
        115                 120                 125             


Gly Pro Pro Glu Val Ile Thr Glu Asp Thr Gln Pro Pro Gln Leu Gly 
    130                 135                 140                 


Gln Glu Arg Asp Pro Gly Gly Thr Pro Ala Gly Gly Thr Asp Glu Pro 
145                 150                 155                 160 


Pro Lys Leu Thr Lys Glu Glu Pro Val Pro Glu Leu Leu Glu Ala Glu 
                165                 170                 175     


Ala Pro Glu Ala Tyr Pro Val Phe Glu Pro Val Pro Ser Val Pro Glu 
            180                 185                 190         


Ala Ala Gln Gly Asp Thr Glu Asp Ser Glu Gly Ala Pro Pro Leu Lys 
        195                 200                 205             


Arg Ile Cys Pro Asn Ala Pro Asp Pro 
    210                 215         


<210> 172
<211> 1590
<212> PRT
<213> Homo sapiens

<400> 172
Met Ser Thr Pro Thr Asp Pro Gly Ala Met Pro His Pro Gly Pro Ser 
1               5                   10                  15      


Pro Gly Pro Gly Pro Ser Pro Gly Pro Ile Leu Gly Pro Ser Pro Gly 
            20                  25                  30          


Pro Gly Pro Ser Pro Gly Ser Val His Ser Met Met Gly Pro Ser Pro 
        35                  40                  45              


Gly Pro Pro Ser Val Ser His Pro Met Pro Thr Met Gly Ser Thr Asp 
    50                  55                  60                  


Phe Pro Gln Glu Gly Met His Gln Met His Lys Pro Ile Asp Gly Ile 
65                  70                  75                  80  


His Asp Lys Gly Ile Val Glu Asp Ile His Cys Gly Ser Met Lys Gly 
                85                  90                  95      


Thr Gly Met Arg Pro Pro His Pro Gly Met Gly Pro Pro Gln Ser Pro 
            100                 105                 110         


Met Asp Gln His Ser Gln Gly Tyr Met Ser Pro His Pro Ser Pro Leu 
        115                 120                 125             


Gly Ala Pro Glu His Val Ser Ser Pro Met Ser Gly Gly Gly Pro Thr 
    130                 135                 140                 


Pro Pro Gln Met Pro Pro Ser Gln Pro Gly Ala Leu Ile Pro Gly Asp 
145                 150                 155                 160 


Pro Gln Ala Met Ser Gln Pro Asn Arg Gly Pro Ser Pro Phe Ser Pro 
                165                 170                 175     


Val Gln Leu His Gln Leu Arg Ala Gln Ile Leu Ala Tyr Lys Met Leu 
            180                 185                 190         


Ala Arg Gly Gln Pro Leu Pro Glu Thr Leu Gln Leu Ala Val Gln Gly 
        195                 200                 205             


Lys Arg Thr Leu Pro Gly Leu Gln Gln Gln Gln Gln Gln Gln Gln Gln 
    210                 215                 220                 


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Pro Gln 
225                 230                 235                 240 


Gln Gln Pro Pro Gln Pro Gln Thr Gln Gln Gln Gln Gln Pro Ala Leu 
                245                 250                 255     


Val Asn Tyr Asn Arg Pro Ser Gly Pro Gly Pro Glu Leu Ser Gly Pro 
            260                 265                 270         


Ser Thr Pro Gln Lys Leu Pro Val Pro Ala Pro Gly Gly Arg Pro Ser 
        275                 280                 285             


Pro Ala Pro Pro Ala Ala Ala Gln Pro Pro Ala Ala Ala Val Pro Gly 
    290                 295                 300                 


Pro Ser Val Pro Gln Pro Ala Pro Gly Gln Pro Ser Pro Val Leu Gln 
305                 310                 315                 320 


Leu Gln Gln Lys Gln Ser Arg Ile Ser Pro Ile Gln Lys Pro Gln Gly 
                325                 330                 335     


Leu Asp Pro Val Glu Ile Leu Gln Glu Arg Glu Tyr Arg Leu Gln Ala 
            340                 345                 350         


Arg Ile Ala His Arg Ile Gln Glu Leu Glu Asn Leu Pro Gly Ser Leu 
        355                 360                 365             


Pro Pro Asp Leu Arg Thr Lys Ala Thr Val Glu Leu Lys Ala Leu Arg 
    370                 375                 380                 


Leu Leu Asn Phe Gln Arg Gln Leu Arg Gln Glu Val Val Ala Cys Met 
385                 390                 395                 400 


Arg Arg Asp Thr Thr Leu Glu Thr Ala Leu Asn Ser Lys Ala Tyr Lys 
                405                 410                 415     


Arg Ser Lys Arg Gln Thr Leu Arg Glu Ala Arg Met Thr Glu Lys Leu 
            420                 425                 430         


Glu Lys Gln Gln Lys Ile Glu Gln Glu Arg Lys Arg Arg Gln Lys His 
        435                 440                 445             


Gln Glu Tyr Leu Asn Ser Ile Leu Gln His Ala Lys Asp Phe Lys Glu 
    450                 455                 460                 


Tyr His Arg Ser Val Ala Gly Lys Ile Gln Lys Leu Ser Lys Ala Val 
465                 470                 475                 480 


Ala Thr Trp His Ala Asn Thr Glu Arg Glu Gln Lys Lys Glu Thr Glu 
                485                 490                 495     


Arg Ile Glu Lys Glu Arg Met Arg Arg Leu Met Ala Glu Asp Glu Glu 
            500                 505                 510         


Gly Tyr Arg Lys Leu Ile Asp Gln Lys Lys Asp Arg Arg Leu Ala Tyr 
        515                 520                 525             


Leu Leu Gln Gln Thr Asp Glu Tyr Val Ala Asn Leu Thr Asn Leu Val 
    530                 535                 540                 


Trp Glu His Lys Gln Ala Gln Ala Ala Lys Glu Lys Lys Lys Arg Arg 
545                 550                 555                 560 


Arg Arg Lys Lys Lys Ala Glu Glu Asn Ala Glu Gly Gly Glu Ser Ala 
                565                 570                 575     


Leu Gly Pro Asp Gly Glu Pro Ile Asp Glu Ser Ser Gln Met Ser Asp 
            580                 585                 590         


Leu Pro Val Lys Val Thr His Thr Glu Thr Gly Lys Val Leu Phe Gly 
        595                 600                 605             


Pro Glu Ala Pro Lys Ala Ser Gln Leu Asp Ala Trp Leu Glu Met Asn 
    610                 615                 620                 


Pro Gly Tyr Glu Val Ala Pro Arg Ser Asp Ser Glu Glu Ser Asp Ser 
625                 630                 635                 640 


Asp Tyr Glu Glu Glu Asp Glu Glu Glu Glu Ser Ser Arg Gln Glu Thr 
                645                 650                 655     


Glu Glu Lys Ile Leu Leu Asp Pro Asn Ser Glu Glu Val Ser Glu Lys 
            660                 665                 670         


Asp Ala Lys Gln Ile Ile Glu Thr Ala Lys Gln Asp Val Asp Asp Glu 
        675                 680                 685             


Tyr Ser Met Gln Tyr Ser Ala Arg Gly Ser Gln Ser Tyr Tyr Thr Val 
    690                 695                 700                 


Ala His Ala Ile Ser Glu Arg Val Glu Lys Gln Ser Ala Leu Leu Ile 
705                 710                 715                 720 


Asn Gly Thr Leu Lys His Tyr Gln Leu Gln Gly Leu Glu Trp Met Val 
                725                 730                 735     


Ser Leu Tyr Asn Asn Asn Leu Asn Gly Ile Leu Ala Asp Glu Met Gly 
            740                 745                 750         


Leu Gly Lys Thr Ile Gln Thr Ile Ala Leu Ile Thr Tyr Leu Met Glu 
        755                 760                 765             


His Lys Arg Leu Asn Gly Pro Tyr Leu Ile Ile Val Pro Leu Ser Thr 
    770                 775                 780                 


Leu Ser Asn Trp Thr Tyr Glu Phe Asp Lys Trp Ala Pro Ser Val Val 
785                 790                 795                 800 


Lys Ile Ser Tyr Lys Gly Thr Pro Ala Met Arg Arg Ser Leu Val Pro 
                805                 810                 815     


Gln Leu Arg Ser Gly Lys Phe Asn Val Leu Leu Thr Thr Tyr Glu Tyr 
            820                 825                 830         


Ile Ile Lys Asp Lys His Ile Leu Ala Lys Ile Arg Trp Lys Tyr Met 
        835                 840                 845             


Ile Val Asp Glu Gly His Arg Met Lys Asn His His Cys Lys Leu Thr 
    850                 855                 860                 


Gln Val Leu Asn Thr His Tyr Val Ala Pro Arg Arg Ile Leu Leu Thr 
865                 870                 875                 880 


Gly Thr Pro Leu Gln Asn Lys Leu Pro Glu Leu Trp Ala Leu Leu Asn 
                885                 890                 895     


Phe Leu Leu Pro Thr Ile Phe Lys Ser Cys Ser Thr Phe Glu Gln Trp 
            900                 905                 910         


Phe Asn Ala Pro Phe Ala Met Thr Gly Glu Arg Val Asp Leu Asn Glu 
        915                 920                 925             


Glu Glu Thr Ile Leu Ile Ile Arg Arg Leu His Lys Val Leu Arg Pro 
    930                 935                 940                 


Phe Leu Leu Arg Arg Leu Lys Lys Glu Val Glu Ser Gln Leu Pro Glu 
945                 950                 955                 960 


Lys Val Glu Tyr Val Ile Lys Cys Asp Met Ser Ala Leu Gln Lys Ile 
                965                 970                 975     


Leu Tyr Arg His Met Gln Ala Lys Gly Ile Leu Leu Thr Asp Gly Ser 
            980                 985                 990         


Glu Lys Asp Lys Lys Gly Lys Gly  Gly Ala Lys Thr Leu  Met Asn Thr 
        995                 1000                 1005             


Ile Met  Gln Leu Arg Lys Ile  Cys Asn His Pro Tyr  Met Phe Gln 
    1010                 1015                 1020             


His Ile  Glu Glu Ser Phe Ala  Glu His Leu Gly Tyr  Ser Asn Gly 
    1025                 1030                 1035             


Val Ile  Asn Gly Ala Glu Leu  Tyr Arg Ala Ser Gly  Lys Phe Glu 
    1040                 1045                 1050             


Leu Leu  Asp Arg Ile Leu Pro  Lys Leu Arg Ala Thr  Asn His Arg 
    1055                 1060                 1065             


Val Leu  Leu Phe Cys Gln Met  Thr Ser Leu Met Thr  Ile Met Glu 
    1070                 1075                 1080             


Asp Tyr  Phe Ala Phe Arg Asn  Phe Leu Tyr Leu Arg  Leu Asp Gly 
    1085                 1090                 1095             


Thr Thr  Lys Ser Glu Asp Arg  Ala Ala Leu Leu Lys  Lys Phe Asn 
    1100                 1105                 1110             


Glu Pro  Gly Ser Gln Tyr Phe  Ile Phe Leu Leu Ser  Thr Arg Ala 
    1115                 1120                 1125             


Gly Gly  Leu Gly Leu Asn Leu  Gln Ala Ala Asp Thr  Val Val Ile 
    1130                 1135                 1140             


Phe Asp  Ser Asp Trp Asn Pro  His Gln Asp Leu Gln  Ala Gln Asp 
    1145                 1150                 1155             


Arg Ala  His Arg Ile Gly Gln  Gln Asn Glu Val Arg  Val Leu Arg 
    1160                 1165                 1170             


Leu Cys  Thr Val Asn Ser Val  Glu Glu Lys Ile Leu  Ala Ala Ala 
    1175                 1180                 1185             


Lys Tyr  Lys Leu Asn Val Asp  Gln Lys Val Ile Gln  Ala Gly Met 
    1190                 1195                 1200             


Phe Asp  Gln Lys Ser Ser Ser  His Glu Arg Arg Ala  Phe Leu Gln 
    1205                 1210                 1215             


Ala Ile  Leu Glu His Glu Glu  Glu Asn Glu Glu Glu  Asp Glu Val 
    1220                 1225                 1230             


Pro Asp  Asp Glu Thr Leu Asn  Gln Met Ile Ala Arg  Arg Glu Glu 
    1235                 1240                 1245             


Glu Phe  Asp Leu Phe Met Arg  Met Asp Met Asp Arg  Arg Arg Glu 
    1250                 1255                 1260             


Asp Ala  Arg Asn Pro Lys Arg  Lys Pro Arg Leu Met  Glu Glu Asp 
    1265                 1270                 1275             


Glu Leu  Pro Ser Trp Ile Ile  Lys Asp Asp Ala Glu  Val Glu Arg 
    1280                 1285                 1290             


Leu Thr  Cys Glu Glu Glu Glu  Glu Lys Ile Phe Gly  Arg Gly Ser 
    1295                 1300                 1305             


Arg Gln  Arg Arg Asp Val Asp  Tyr Ser Asp Ala Leu  Thr Glu Lys 
    1310                 1315                 1320             


Gln Trp  Leu Arg Ala Ile Glu  Asp Gly Asn Leu Glu  Glu Met Glu 
    1325                 1330                 1335             


Glu Glu  Val Arg Leu Lys Lys  Arg Lys Arg Arg Arg  Asn Val Asp 
    1340                 1345                 1350             


Lys Asp  Pro Ala Lys Glu Asp  Val Glu Lys Ala Lys  Lys Arg Arg 
    1355                 1360                 1365             


Gly Arg  Pro Pro Ala Glu Lys  Leu Ser Pro Asn Pro  Pro Lys Leu 
    1370                 1375                 1380             


Thr Lys  Gln Met Asn Ala Ile  Ile Asp Thr Val Ile  Asn Tyr Lys 
    1385                 1390                 1395             


Asp Arg  Cys Asn Val Glu Lys  Val Pro Ser Asn Ser  Gln Leu Glu 
    1400                 1405                 1410             


Ile Glu  Gly Asn Ser Ser Gly  Arg Gln Leu Ser Glu  Val Phe Ile 
    1415                 1420                 1425             


Gln Leu  Pro Ser Arg Lys Glu  Leu Pro Glu Tyr Tyr  Glu Leu Ile 
    1430                 1435                 1440             


Arg Lys  Pro Val Asp Phe Lys  Lys Ile Lys Glu Arg  Ile Arg Asn 
    1445                 1450                 1455             


His Lys  Tyr Arg Ser Leu Gly  Asp Leu Glu Lys Asp  Val Met Leu 
    1460                 1465                 1470             


Leu Cys  His Asn Ala Gln Thr  Phe Asn Leu Glu Gly  Ser Gln Ile 
    1475                 1480                 1485             


Tyr Glu  Asp Ser Ile Val Leu  Gln Ser Val Phe Lys  Ser Ala Arg 
    1490                 1495                 1500             


Gln Lys  Ile Ala Lys Glu Glu  Glu Ser Glu Asp Glu  Ser Asn Glu 
    1505                 1510                 1515             


Glu Glu  Glu Glu Glu Asp Glu  Glu Glu Ser Glu Ser  Glu Ala Lys 
    1520                 1525                 1530             


Ser Val  Lys Val Lys Ile Lys  Leu Asn Lys Lys Asp  Asp Lys Gly 
    1535                 1540                 1545             


Arg Asp  Lys Gly Lys Gly Lys  Lys Arg Pro Asn Arg  Gly Lys Ala 
    1550                 1555                 1560             


Lys Pro  Val Val Ser Asp Phe  Asp Ser Asp Glu Glu  Gln Asp Glu 
    1565                 1570                 1575             


Arg Glu  Gln Ser Glu Gly Ser  Gly Thr Asp Asp Glu  
    1580                 1585                 1590 


<210> 173
<211> 5892
<212> DNA
<213> Homo sapiens

<400> 173
gcgtcttccg gcgcccgcgg aggaggcgag ggtgggacgc tgggcggagc ccgagtttag       60

gaagaggagg ggacggctgt catcaatgaa gtcatattca taatctagtc ctctctccct      120

ctgtttctgt actctgggtg actcagagag ggaagagatt cagccagcac actcctcgcg      180

agcaagcatt actctactga ctggcagaga caggagaggt agatgtccac gcccacagac      240

cctggtgcga tgccccaccc agggccttcg ccggggcctg ggccttcccc tgggccaatt      300

cttgggccta gtccaggacc aggaccatcc ccaggttccg tccacagcat gatggggcca      360

agtcctggac ctccaagtgt ctcccatcct atgccgacga tggggtccac agacttccca      420

caggaaggca tgcatcaaat gcataagccc atcgatggta tacatgacaa ggggattgta      480

gaagacatcc attgtggatc catgaagggc actggtatgc gaccacctca cccaggcatg      540

ggccctcccc agagtccaat ggatcaacac agccaaggtt atatgtcacc acacccatct      600

ccattaggag ccccagagca cgtctccagc cctatgtctg gaggaggccc aactccacct      660

cagatgccac caagccagcc gggggccctc atcccaggtg atccgcaggc catgagccag      720

cccaacagag gtccctcacc tttcagtcct gtccagctgc atcagcttcg agctcagatt      780

ttagcttata aaatgctggc ccgaggccag cccctccccg aaacgctgca gcttgcagtc      840

caggggaaaa ggacgttgcc tggcttgcag caacaacagc agcagcaaca gcagcagcag      900

cagcagcagc agcagcagca gcagcagcaa cagcagccgc agcagcagcc gccgcaacca      960

cagacgcagc aacaacagca gccggccctt gttaactaca acagaccatc tggcccgggg     1020

ccggagctga gcggcccgag caccccgcag aagctgccgg tgcccgcgcc cggcggccgg     1080

ccctcgcccg cgccccccgc agccgcgcag ccgcccgcgg ccgcagtgcc cgggccctca     1140

gtgccgcagc cggccccggg gcagccctcg cccgtcctcc agctgcagca gaagcagagc     1200

cgcatcagcc ccatccagaa accgcaaggc ctggaccccg tggaaattct gcaagagcgg     1260

gaatacagac ttcaggcccg catagctcat aggatacaag aactggaaaa tctgcctggc     1320

tctttgccac cagatttaag aaccaaagca accgtggaac taaaagcact tcggttactc     1380

aatttccagc gtcagctgag acaggaggtg gtggcctgca tgcgcaggga cacgaccctg     1440

gagacggctc tcaactccaa agcatacaaa cggagcaagc gccagactct gagagaagct     1500

cgcatgaccg agaagctgga gaagcagcag aagattgagc aggagaggaa acgccgtcag     1560

aaacaccagg aatacctgaa cagtattttg caacatgcaa aagattttaa ggaatatcat     1620

cggtctgtgg ccggaaagat ccagaagctc tccaaagcag tggcaacttg gcatgccaac     1680

actgaaagag agcagaagaa ggagacagag cggattgaaa aggagagaat gcggcgactg     1740

atggctgaag atgaggaggg ttatagaaaa ctgattgatc aaaagaaaga caggcgttta     1800

gcttaccttt tgcagcagac cgatgagtat gtagccaatc tgaccaatct ggtttgggag     1860

cacaagcaag cccaggcagc caaagagaag aagaagagga ggaggaggaa gaagaaggct     1920

gaggagaatg cagagggtgg ggagtctgcc ctgggaccgg atggagagcc catagatgag     1980

agcagccaga tgagtgacct ccctgtcaaa gtgactcaca cagaaaccgg caaggttctg     2040

ttcggaccag aagcacccaa agcaagtcag ctggacgcct ggctggaaat gaatcctggt     2100

tatgaagttg cccctagatc tgacagtgaa gagagtgatt ctgattatga ggaagaggat     2160

gaggaagaag agtccagtag gcaggaaacc gaagagaaaa tactcctgga tccaaatagc     2220

gaagaagttt ctgagaagga tgctaagcag atcattgaga cagctaagca agacgtggat     2280

gatgaataca gcatgcagta cagtgccagg ggctcccagt cctactacac cgtggctcat     2340

gccatctcgg agagggtgga gaaacagtct gccctcctaa ttaatgggac cctaaagcat     2400

taccagctcc agggcctgga atggatggtt tccctgtata ataacaactt gaacggaatc     2460

ttagccgatg aaatggggct tggaaagacc atacagacca ttgcactcat cacttatctg     2520

atggagcaca aaagactcaa tggcccctat ctcatcattg ttcccctttc gactctatct     2580

aactggacat atgaatttga caaatgggct ccttctgtgg tgaagatttc ttacaagggt     2640

actcctgcca tgcgtcgctc ccttgtcccc cagctacgga gtggcaaatt caatgtcctc     2700

ttgactactt atgagtatat tataaaagac aagcacattc ttgcaaagat tcggtggaaa     2760

tacatgatag tggacgaagg ccaccgaatg aagaatcacc actgcaagct gactcaggtc     2820

ttgaacactc actatgtggc ccccagaagg atcctcttga ctgggacccc gctgcagaat     2880

aagctccctg aactctgggc cctcctcaac ttcctcctcc caacaatttt taagagctgc     2940

agcacatttg aacaatggtt caatgctcca tttgccatga ctggtgaaag ggtggactta     3000

aatgaagaag aaactatatt gatcatcagg cgtctacata aggtgttaag accattttta     3060

ctaaggagac tgaagaaaga agttgaatcc cagcttcccg aaaaagtgga atatgtgatc     3120

aagtgtgaca tgtcagctct gcagaagatt ctgtatcgcc atatgcaagc caaggggatc     3180

cttctcacag atggttctga gaaagataag aaggggaaag gaggtgctaa gacacttatg     3240

aacactatta tgcagttgag aaaaatctgc aaccacccat atatgtttca gcacattgag     3300

gaatcctttg ctgaacacct aggctattca aatggggtca tcaatggggc tgaactgtat     3360

cgggcctcag ggaagtttga gctgcttgat cgtattctgc caaaattgag agcgactaat     3420

caccgagtgc tgcttttctg ccagatgaca tctctcatga ccatcatgga ggattatttt     3480

gcttttcgga acttccttta cctacgcctt gatggcacca ccaagtctga agatcgtgct     3540

gctttgctga agaaattcaa tgaacctgga tcccagtatt tcattttctt gctgagcaca     3600

agagctggtg gcctgggctt aaatcttcag gcagctgata cagtggtcat ctttgacagc     3660

gactggaatc ctcatcagga tctgcaggcc caagaccgag ctcaccgcat cgggcagcag     3720

aacgaggtcc gggtactgag gctctgtacc gtgaacagcg tggaggaaaa gatcctcgcg     3780

gccgcaaaat acaagctgaa cgtggatcag aaagtgatcc aggcgggcat gtttgaccaa     3840

aagtcttcaa gccacgagcg gagggcattc ctgcaggcca tcttggagca tgaggaggaa     3900

aatgaggaag aagatgaagt accggacgat gagactctga accaaatgat tgctcgacga     3960

gaagaagaat ttgacctttt tatgcggatg gacatggacc ggcggaggga agatgcccgg     4020

aacccgaaac ggaagccccg tttaatggag gaggatgagc tgccctcctg gatcattaag     4080

gatgacgctg aagtagaaag gctcacctgt gaagaagagg aggagaaaat atttgggagg     4140

gggtcccgcc agcgccgtga cgtggactac agtgacgccc tcacggagaa gcagtggcta     4200

agggccatcg aagacggcaa tttggaggaa atggaagagg aagtacggct taagaagcga     4260

aaaagacgaa gaaatgtgga taaagatcct gcaaaagaag atgtggaaaa agctaagaag     4320

agaagaggcc gccctcccgc tgagaaactg tcaccaaatc cccccaaact gacaaagcag     4380

atgaacgcta tcatcgatac tgtgataaac tacaaagata ggtgtaacgt ggagaaggtg     4440

cccagtaatt ctcagttgga aatagaagga aacagttcag ggcgacagct cagtgaagtc     4500

ttcattcagt taccttcaag gaaagaatta ccagaatact atgaattaat taggaagcca     4560

gtggatttca aaaaaataaa ggaaaggatt cgtaatcata agtaccggag cctaggcgac     4620

ctggagaagg atgtcatgct tctctgtcac aacgctcaga cgttcaacct ggagggatcc     4680

cagatctatg aagactccat cgtcttacag tcagtgttta agagtgcccg gcagaaaatt     4740

gccaaagagg aagagagtga ggatgaaagc aatgaagagg aggaagagga agatgaagaa     4800

gagtcagagt ccgaggcaaa atcagtcaag gtgaaaatta agctcaataa aaaagatgac     4860

aaaggccggg acaaagggaa aggcaagaaa aggccaaatc gaggaaaagc caaacctgta     4920

gtgagcgatt ttgacagcga tgaggagcag gatgaacgtg aacagtcaga aggaagtggg     4980

acggatgatg agtgatcagt atggaccttt ttccttggta gaactgaatt ccttcctccc     5040

ctgtctcatt tctacccagt gagttcattt gtcatatagg cactgggttg tttctatatc     5100

atcatcgtct ataaactagc tttaggatag tgccagacaa acatatgata tcatggtgta     5160

aaaaacacac acatacacaa atatttgtaa catattgtga ccaaatgggc ctcaaagatt     5220

cagattgaaa caaacaaaaa gcttttgatg gaaaatatgt gggtggatag tatatttcta     5280

tgggtgggtc taatttggta acggtttgat tgtgcctggt tttatcacct gttcagatga     5340

gaagattttt gtcttttgta gcactgataa ccaggagaag ccattaaaag ccactggtta     5400

ttttattttt catcaggcaa ttttcgaggt ttttatttgt tcggtattgt ttttttacac     5460

tgtggtacat ataagcaact ttaataggtg ataaatgtac agtagttaga tttcacctgc     5520

atatacattt ttccatttta tgctctatga tctgaacaaa agctttttga attgtataag     5580

atttatgtct actgtaaaca ttgcttaatt tttttgctct tgatttaaaa aaaagttttg     5640

ttgaaagcgc tattgaatat tgcaatctat atagtgtatt ggatggcttc ttttgtcacc     5700

ctgatctcct atgttaccaa tgtgtatcgt ctccttctcc ctaaagtgta cttaatcttt     5760

gctttctttg cacaatgtct ttggttgcaa gtcataagcc tgaggcaaat aaaattccag     5820

taatttcgaa gaatgtggtg ttggtgcttt cctaataaag aaataattta gcttgacaaa     5880

aaaaaaaaaa aa                                                         5892


<210> 174
<211> 5879
<212> DNA
<213> Homo sapiens

<400> 174
tcagaagaaa gccccgagat cacagagacc cggcgagatc acagagaccc ggcctgaagg       60

aacgtggaaa gaccaatgta cctgttttga ccggttgcct ggagcaagaa gttccagttg      120

gggagaattt tcagaagata aagtcggaga ttgtggaaag acttgacttg cagcattact      180

ctactgactg gcagagacag gagaggtaga tgtccacgcc cacagaccct ggtgcgatgc      240

cccacccagg gccttcgccg gggcctgggc cttcccctgg gccaattctt gggcctagtc      300

caggaccagg accatcccca ggttccgtcc acagcatgat ggggccaagt cctggacctc      360

caagtgtctc ccatcctatg ccgacgatgg ggtccacaga cttcccacag gaaggcatgc      420

atcaaatgca taagcccatc gatggtatac atgacaaggg gattgtagaa gacatccatt      480

gtggatccat gaagggcact ggtatgcgac cacctcaccc aggcatgggc cctccccaga      540

gtccaatgga tcaacacagc caaggttata tgtcaccaca cccatctcca ttaggagccc      600

cagagcacgt ctccagccct atgtctggag gaggcccaac tccacctcag atgccaccaa      660

gccagccggg ggccctcatc ccaggtgatc cgcaggccat gagccagccc aacagaggtc      720

cctcaccttt cagtcctgtc cagctgcatc agcttcgagc tcagatttta gcttataaaa      780

tgctggcccg aggccagccc ctccccgaaa cgctgcagct tgcagtccag gggaaaagga      840

cgttgcctgg cttgcagcaa caacagcagc agcaacagca gcagcagcag cagcagcagc      900

agcagcagca gcagcaacag cagccgcagc agcagccgcc gcaaccacag acgcagcaac      960

aacagcagcc ggcccttgtt aactacaaca gaccatctgg cccggggccg gagctgagcg     1020

gcccgagcac cccgcagaag ctgccggtgc ccgcgcccgg cggccggccc tcgcccgcgc     1080

cccccgcagc cgcgcagccg cccgcggccg cagtgcccgg gccctcagtg ccgcagccgg     1140

ccccggggca gccctcgccc gtcctccagc tgcagcagaa gcagagccgc atcagcccca     1200

tccagaaacc gcaaggcctg gaccccgtgg aaattctgca agagcgggaa tacagacttc     1260

aggcccgcat agctcatagg atacaagaac tggaaaatct gcctggctct ttgccaccag     1320

atttaagaac caaagcaacc gtggaactaa aagcacttcg gttactcaat ttccagcgtc     1380

agctgagaca ggaggtggtg gcctgcatgc gcagggacac gaccctggag acggctctca     1440

actccaaagc atacaaacgg agcaagcgcc agactctgag agaagctcgc atgaccgaga     1500

agctggagaa gcagcagaag attgagcagg agaggaaacg ccgtcagaaa caccaggaat     1560

acctgaacag tattttgcaa catgcaaaag attttaagga atatcatcgg tctgtggccg     1620

gaaagatcca gaagctctcc aaagcagtgg caacttggca tgccaacact gaaagagagc     1680

agaagaagga gacagagcgg attgaaaagg agagaatgcg gcgactgatg gctgaagatg     1740

aggagggtta tagaaaactg attgatcaaa agaaagacag gcgtttagct taccttttgc     1800

agcagaccga tgagtatgta gccaatctga ccaatctggt ttgggagcac aagcaagccc     1860

aggcagccaa agagaagaag aagaggagga ggaggaagaa gaaggctgag gagaatgcag     1920

agggtgggga gtctgccctg ggaccggatg gagagcccat agatgagagc agccagatga     1980

gtgacctccc tgtcaaagtg actcacacag aaaccggcaa ggttctgttc ggaccagaag     2040

cacccaaagc aagtcagctg gacgcctggc tggaaatgaa tcctggttat gaagttgccc     2100

ctagatctga cagtgaagag agtgattctg attatgagga agaggatgag gaagaagagt     2160

ccagtaggca ggaaaccgaa gagaaaatac tcctggatcc aaatagcgaa gaagtttctg     2220

agaaggatgc taagcagatc attgagacag ctaagcaaga cgtggatgat gaatacagca     2280

tgcagtacag tgccaggggc tcccagtcct actacaccgt ggctcatgcc atctcggaga     2340

gggtggagaa acagtctgcc ctcctaatta atgggaccct aaagcattac cagctccagg     2400

gcctggaatg gatggtttcc ctgtataata acaacttgaa cggaatctta gccgatgaaa     2460

tggggcttgg aaagaccata cagaccattg cactcatcac ttatctgatg gagcacaaaa     2520

gactcaatgg cccctatctc atcattgttc ccctttcgac tctatctaac tggacatatg     2580

aatttgacaa atgggctcct tctgtggtga agatttctta caagggtact cctgccatgc     2640

gtcgctccct tgtcccccag ctacggagtg gcaaattcaa tgtcctcttg actacttatg     2700

agtatattat aaaagacaag cacattcttg caaagattcg gtggaaatac atgatagtgg     2760

acgaaggcca ccgaatgaag aatcaccact gcaagctgac tcaggtcttg aacactcact     2820

atgtggcccc cagaaggatc ctcttgactg ggaccccgct gcagaataag ctccctgaac     2880

tctgggccct cctcaacttc ctcctcccaa caatttttaa gagctgcagc acatttgaac     2940

aatggttcaa tgctccattt gccatgactg gtgaaagggt ggacttaaat gaagaagaaa     3000

ctatattgat catcaggcgt ctacataagg tgttaagacc atttttacta aggagactga     3060

agaaagaagt tgaatcccag cttcccgaaa aagtggaata tgtgatcaag tgtgacatgt     3120

cagctctgca gaagattctg tatcgccata tgcaagccaa ggggatcctt ctcacagatg     3180

gttctgagaa agataagaag gggaaaggag gtgctaagac acttatgaac actattatgc     3240

agttgagaaa aatctgcaac cacccatata tgtttcagca cattgaggaa tcctttgctg     3300

aacacctagg ctattcaaat ggggtcatca atggggctga actgtatcgg gcctcaggga     3360

agtttgagct gcttgatcgt attctgccaa aattgagagc gactaatcac cgagtgctgc     3420

ttttctgcca gatgacatct ctcatgacca tcatggagga ttattttgct tttcggaact     3480

tcctttacct acgccttgat ggcaccacca agtctgaaga tcgtgctgct ttgctgaaga     3540

aattcaatga acctggatcc cagtatttca ttttcttgct gagcacaaga gctggtggcc     3600

tgggcttaaa tcttcaggca gctgatacag tggtcatctt tgacagcgac tggaatcctc     3660

atcaggatct gcaggcccaa gaccgagctc accgcatcgg gcagcagaac gaggtccggg     3720

tactgaggct ctgtaccgtg aacagcgtgg aggaaaagat cctcgcggcc gcaaaataca     3780

agctgaacgt ggatcagaaa gtgatccagg cgggcatgtt tgaccaaaag tcttcaagcc     3840

acgagcggag ggcattcctg caggccatct tggagcatga ggaggaaaat gaggaagaag     3900

atgaagtacc ggacgatgag actctgaacc aaatgattgc tcgacgagaa gaagaatttg     3960

acctttttat gcggatggac atggaccggc ggagggaaga tgcccggaac ccgaaacgga     4020

agccccgttt aatggaggag gatgagctgc cctcctggat cattaaggat gacgctgaag     4080

tagaaaggct cacctgtgaa gaagaggagg agaaaatatt tgggaggggg tcccgccagc     4140

gccgtgacgt ggactacagt gacgccctca cggagaagca gtggctaagg gccatcgaag     4200

acggcaattt ggaggaaatg gaagaggaag tacggcttaa gaagcgaaaa agacgaagaa     4260

atgtggataa agatcctgca aaagaagatg tggaaaaagc taagaagaga agaggccgcc     4320

ctcccgctga gaaactgtca ccaaatcccc ccaaactgac aaagcagatg aacgctatca     4380

tcgatactgt gataaactac aaagataggt gtaacgtgga gaaggtgccc agtaattctc     4440

agttggaaat agaaggaaac agttcagggc gacagctcag tgaagtcttc attcagttac     4500

cttcaaggaa agaattacca gaatactatg aattaattag gaagccagtg gatttcaaaa     4560

aaataaagga aaggattcgt aatcataagt accggagcct aggcgacctg gagaaggatg     4620

tcatgcttct ctgtcacaac gctcagacgt tcaacctgga gggatcccag atctatgaag     4680

actccatcgt cttacagtca gtgtttaaga gtgcccggca gaaaattgcc aaagaggaag     4740

agagtgagga tgaaagcaat gaagaggagg aagaggaaga tgaagaagag tcagagtccg     4800

aggcaaaatc agtcaaggtg aaaattaagc tcaataaaaa agatgacaaa ggccgggaca     4860

aagggaaagg caagaaaagg ccaaatcgag gaaaagccaa acctgtagtg agcgattttg     4920

acagcgatga ggagcaggat gaacgtgaac agtcagaagg aagtgggacg gatgatgagt     4980

gatcagtatg gacctttttc cttggtagaa ctgaattcct tcctcccctg tctcatttct     5040

acccagtgag ttcatttgtc atataggcac tgggttgttt ctatatcatc atcgtctata     5100

aactagcttt aggatagtgc cagacaaaca tatgatatca tggtgtaaaa aacacacaca     5160

tacacaaata tttgtaacat attgtgacca aatgggcctc aaagattcag attgaaacaa     5220

acaaaaagct tttgatggaa aatatgtggg tggatagtat atttctatgg gtgggtctaa     5280

tttggtaacg gtttgattgt gcctggtttt atcacctgtt cagatgagaa gatttttgtc     5340

ttttgtagca ctgataacca ggagaagcca ttaaaagcca ctggttattt tatttttcat     5400

caggcaattt tcgaggtttt tatttgttcg gtattgtttt tttacactgt ggtacatata     5460

agcaacttta ataggtgata aatgtacagt agttagattt cacctgcata tacatttttc     5520

cattttatgc tctatgatct gaacaaaagc tttttgaatt gtataagatt tatgtctact     5580

gtaaacattg cttaattttt ttgctcttga tttaaaaaaa agttttgttg aaagcgctat     5640

tgaatattgc aatctatata gtgtattgga tggcttcttt tgtcaccctg atctcctatg     5700

ttaccaatgt gtatcgtctc cttctcccta aagtgtactt aatctttgct ttctttgcac     5760

aatgtctttg gttgcaagtc ataagcctga ggcaaataaa attccagtaa tttcgaagaa     5820

tgtggtgttg gtgctttcct aataaagaaa taatttagct tgacaaaaaa aaaaaaaaa      5879


<210> 175
<211> 1572
<212> PRT
<213> Homo sapiens

<400> 175
Met Ser Thr Pro Thr Asp Pro Gly Ala Met Pro His Pro Gly Pro Ser 
1               5                   10                  15      


Pro Gly Pro Gly Pro Ser Pro Gly Pro Ile Leu Gly Pro Ser Pro Gly 
            20                  25                  30          


Pro Gly Pro Ser Pro Gly Ser Val His Ser Met Met Gly Pro Ser Pro 
        35                  40                  45              


Gly Pro Pro Ser Val Ser His Pro Met Pro Thr Met Gly Ser Thr Asp 
    50                  55                  60                  


Phe Pro Gln Glu Gly Met His Gln Met His Lys Pro Ile Asp Gly Ile 
65                  70                  75                  80  


His Asp Lys Gly Ile Val Glu Asp Ile His Cys Gly Ser Met Lys Gly 
                85                  90                  95      


Thr Gly Met Arg Pro Pro His Pro Gly Met Gly Pro Pro Gln Ser Pro 
            100                 105                 110         


Met Asp Gln His Ser Gln Gly Tyr Met Ser Pro His Pro Ser Pro Leu 
        115                 120                 125             


Gly Ala Pro Glu His Val Ser Ser Pro Met Ser Gly Gly Gly Pro Thr 
    130                 135                 140                 


Pro Pro Gln Met Pro Pro Ser Gln Pro Gly Ala Leu Ile Pro Gly Asp 
145                 150                 155                 160 


Pro Gln Ala Met Ser Gln Pro Asn Arg Gly Pro Ser Pro Phe Ser Pro 
                165                 170                 175     


Val Gln Leu His Gln Leu Arg Ala Gln Ile Leu Ala Tyr Lys Met Leu 
            180                 185                 190         


Ala Arg Gly Gln Pro Leu Pro Glu Thr Leu Gln Leu Ala Val Gln Gly 
        195                 200                 205             


Lys Arg Thr Leu Pro Gly Leu Gln Gln Gln Gln Gln Gln Gln Gln Gln 
    210                 215                 220                 


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Pro Gln 
225                 230                 235                 240 


Gln Gln Pro Pro Gln Pro Gln Thr Gln Gln Gln Gln Gln Pro Ala Leu 
                245                 250                 255     


Val Asn Tyr Asn Arg Pro Ser Gly Pro Gly Pro Glu Leu Ser Gly Pro 
            260                 265                 270         


Ser Thr Pro Gln Lys Leu Pro Val Pro Ala Pro Gly Gly Arg Pro Ser 
        275                 280                 285             


Pro Ala Pro Pro Ala Ala Ala Gln Pro Pro Ala Ala Ala Val Pro Gly 
    290                 295                 300                 


Pro Ser Val Pro Gln Pro Ala Pro Gly Gln Pro Ser Pro Val Leu Gln 
305                 310                 315                 320 


Leu Gln Gln Lys Gln Ser Arg Ile Ser Pro Ile Gln Lys Pro Gln Gly 
                325                 330                 335     


Leu Asp Pro Val Glu Ile Leu Gln Glu Arg Glu Tyr Arg Leu Gln Ala 
            340                 345                 350         


Arg Ile Ala His Arg Ile Gln Glu Leu Glu Asn Leu Pro Gly Ser Leu 
        355                 360                 365             


Pro Pro Asp Leu Arg Thr Lys Ala Thr Val Glu Leu Lys Ala Leu Arg 
    370                 375                 380                 


Leu Leu Asn Phe Gln Arg Gln Leu Arg Gln Glu Val Val Ala Cys Met 
385                 390                 395                 400 


Arg Arg Asp Thr Thr Leu Glu Thr Ala Leu Asn Ser Lys Ala Tyr Lys 
                405                 410                 415     


Arg Ser Lys Arg Gln Thr Leu Arg Glu Ala Arg Met Thr Glu Lys Leu 
            420                 425                 430         


Glu Lys Gln Gln Lys Ile Glu Gln Glu Arg Lys Arg Arg Gln Lys His 
        435                 440                 445             


Gln Glu Tyr Leu Asn Ser Ile Leu Gln His Ala Lys Asp Phe Lys Glu 
    450                 455                 460                 


Tyr His Arg Ser Val Ala Gly Lys Ile Gln Lys Leu Ser Lys Ala Val 
465                 470                 475                 480 


Ala Thr Trp His Ala Asn Thr Glu Arg Glu Gln Lys Lys Glu Thr Glu 
                485                 490                 495     


Arg Ile Glu Lys Glu Arg Met Arg Arg Leu Met Ala Glu Asp Glu Glu 
            500                 505                 510         


Gly Tyr Arg Lys Leu Ile Asp Gln Lys Lys Asp Arg Arg Leu Ala Tyr 
        515                 520                 525             


Leu Leu Gln Gln Thr Asp Glu Tyr Val Ala Asn Leu Thr Asn Leu Val 
    530                 535                 540                 


Trp Glu His Lys Gln Ala Gln Ala Ala Lys Glu Lys Lys Lys Arg Arg 
545                 550                 555                 560 


Arg Arg Lys Lys Lys Ala Glu Glu Asn Ala Glu Gly Gly Glu Ser Ala 
                565                 570                 575     


Leu Gly Pro Asp Gly Glu Pro Ile Asp Glu Ser Ser Gln Met Ser Asp 
            580                 585                 590         


Leu Pro Val Lys Val Thr His Thr Glu Thr Gly Lys Val Leu Phe Gly 
        595                 600                 605             


Pro Glu Ala Pro Lys Ala Ser Gln Leu Asp Ala Trp Leu Glu Met Asn 
    610                 615                 620                 


Pro Gly Tyr Glu Val Ala Pro Arg Ser Asp Ser Glu Glu Ser Asp Ser 
625                 630                 635                 640 


Asp Tyr Glu Glu Glu Asp Glu Glu Glu Glu Ser Ser Arg Gln Glu Thr 
                645                 650                 655     


Glu Glu Lys Ile Leu Leu Asp Pro Asn Ser Glu Glu Val Ser Glu Lys 
            660                 665                 670         


Asp Ala Lys Gln Ile Ile Glu Thr Ala Lys Gln Asp Val Asp Asp Glu 
        675                 680                 685             


Tyr Ser Met Gln Tyr Ser Ala Arg Gly Ser Gln Ser Tyr Tyr Thr Val 
    690                 695                 700                 


Ala His Ala Ile Ser Glu Arg Val Glu Lys Gln Ser Ala Leu Leu Ile 
705                 710                 715                 720 


Asn Gly Thr Leu Lys His Tyr Gln Leu Gln Gly Leu Glu Trp Met Val 
                725                 730                 735     


Ser Leu Tyr Asn Asn Asn Leu Asn Gly Ile Leu Ala Asp Glu Met Gly 
            740                 745                 750         


Leu Gly Lys Thr Ile Gln Thr Ile Ala Leu Ile Thr Tyr Leu Met Glu 
        755                 760                 765             


His Lys Arg Leu Asn Gly Pro Tyr Leu Ile Ile Val Pro Leu Ser Thr 
    770                 775                 780                 


Leu Ser Asn Trp Thr Tyr Glu Phe Asp Lys Trp Ala Pro Ser Val Val 
785                 790                 795                 800 


Lys Ile Ser Tyr Lys Gly Thr Pro Ala Met Arg Arg Ser Leu Val Pro 
                805                 810                 815     


Gln Leu Arg Ser Gly Lys Phe Asn Val Leu Leu Thr Thr Tyr Glu Tyr 
            820                 825                 830         


Ile Ile Lys Asp Lys His Ile Leu Ala Lys Ile Arg Trp Lys Tyr Met 
        835                 840                 845             


Ile Val Asp Glu Gly His Arg Met Lys Asn His His Cys Lys Leu Thr 
    850                 855                 860                 


Gln Val Leu Asn Thr His Tyr Val Ala Pro Arg Arg Ile Leu Leu Thr 
865                 870                 875                 880 


Gly Thr Pro Leu Gln Asn Lys Leu Pro Glu Leu Trp Ala Leu Leu Asn 
                885                 890                 895     


Phe Leu Leu Pro Thr Ile Phe Lys Ser Cys Ser Thr Phe Glu Gln Trp 
            900                 905                 910         


Phe Asn Ala Pro Phe Ala Met Thr Gly Glu Arg Val Asp Leu Asn Glu 
        915                 920                 925             


Glu Glu Thr Ile Leu Ile Ile Arg Arg Leu His Lys Val Leu Arg Pro 
    930                 935                 940                 


Phe Leu Leu Arg Arg Leu Lys Lys Glu Val Glu Ser Gln Leu Pro Glu 
945                 950                 955                 960 


Lys Val Glu Tyr Val Ile Lys Cys Asp Met Ser Ala Leu Gln Lys Ile 
                965                 970                 975     


Leu Tyr Arg His Met Gln Ala Lys Gly Ile Leu Leu Thr Asp Gly Ser 
            980                 985                 990         


Glu Lys Asp Lys Lys Gly Lys Gly  Gly Ala Lys Thr Leu  Met Asn Thr 
        995                 1000                 1005             


Ile Met  Gln Leu Arg Lys Ile  Cys Asn His Pro Tyr  Met Phe Gln 
    1010                 1015                 1020             


His Ile  Glu Glu Ser Phe Ala  Glu His Leu Gly Tyr  Ser Asn Gly 
    1025                 1030                 1035             


Val Ile  Asn Gly Ala Glu Leu  Tyr Arg Ala Ser Gly  Lys Phe Glu 
    1040                 1045                 1050             


Leu Leu  Asp Arg Ile Leu Pro  Lys Leu Arg Ala Thr  Asn His Arg 
    1055                 1060                 1065             


Val Leu  Leu Phe Cys Gln Met  Thr Ser Leu Met Thr  Ile Met Glu 
    1070                 1075                 1080             


Asp Tyr  Phe Ala Phe Arg Asn  Phe Leu Tyr Leu Arg  Leu Asp Gly 
    1085                 1090                 1095             


Thr Thr  Lys Ser Glu Asp Arg  Ala Ala Leu Leu Lys  Lys Phe Asn 
    1100                 1105                 1110             


Glu Pro  Gly Ser Gln Tyr Phe  Ile Phe Leu Leu Ser  Thr Arg Ala 
    1115                 1120                 1125             


Gly Gly  Leu Gly Leu Asn Leu  Gln Ala Ala Asp Thr  Val Val Ile 
    1130                 1135                 1140             


Phe Asp  Ser Asp Trp Asn Pro  His Gln Asp Leu Gln  Ala Gln Asp 
    1145                 1150                 1155             


Arg Ala  His Arg Ile Gly Gln  Gln Asn Glu Val Arg  Val Leu Arg 
    1160                 1165                 1170             


Leu Cys  Thr Val Asn Ser Val  Glu Glu Lys Ile Leu  Ala Ala Ala 
    1175                 1180                 1185             


Lys Tyr  Lys Leu Asn Val Asp  Gln Lys Val Ile Gln  Ala Gly Met 
    1190                 1195                 1200             


Phe Asp  Gln Lys Ser Ser Ser  His Glu Arg Arg Ala  Phe Leu Gln 
    1205                 1210                 1215             


Ala Ile  Leu Glu His Glu Glu  Glu Asn Glu Glu Glu  Asp Glu Val 
    1220                 1225                 1230             


Pro Asp  Asp Glu Thr Leu Asn  Gln Met Ile Ala Arg  Arg Glu Glu 
    1235                 1240                 1245             


Glu Phe  Asp Leu Phe Met Arg  Met Asp Met Asp Arg  Arg Arg Glu 
    1250                 1255                 1260             


Asp Ala  Arg Asn Pro Lys Arg  Lys Pro Arg Leu Met  Glu Glu Asp 
    1265                 1270                 1275             


Glu Leu  Pro Ser Trp Ile Ile  Lys Asp Asp Ala Glu  Val Glu Arg 
    1280                 1285                 1290             


Leu Thr  Cys Glu Glu Glu Glu  Glu Lys Ile Phe Gly  Arg Gly Ser 
    1295                 1300                 1305             


Arg Gln  Arg Arg Asp Val Asp  Tyr Ser Asp Ala Leu  Thr Glu Lys 
    1310                 1315                 1320             


Gln Trp  Leu Arg Ala Ile Glu  Asp Gly Asn Leu Glu  Glu Met Glu 
    1325                 1330                 1335             


Glu Glu  Val Arg Leu Lys Lys  Arg Lys Arg Arg Arg  Asn Val Asp 
    1340                 1345                 1350             


Lys Asp  Pro Ala Lys Glu Asp  Val Glu Lys Ala Lys  Lys Arg Arg 
    1355                 1360                 1365             


Gly Arg  Pro Pro Ala Glu Lys  Leu Ser Pro Asn Pro  Pro Lys Leu 
    1370                 1375                 1380             


Thr Lys  Gln Met Asn Ala Ile  Ile Asp Thr Val Ile  Asn Tyr Lys 
    1385                 1390                 1395             


Asp Ser  Ser Gly Arg Gln Leu  Ser Glu Val Phe Ile  Gln Leu Pro 
    1400                 1405                 1410             


Ser Arg  Lys Glu Leu Pro Glu  Tyr Tyr Glu Leu Ile  Arg Lys Pro 
    1415                 1420                 1425             


Val Asp  Phe Lys Lys Ile Lys  Glu Arg Ile Arg Asn  His Lys Tyr 
    1430                 1435                 1440             


Arg Ser  Leu Gly Asp Leu Glu  Lys Asp Val Met Leu  Leu Cys His 
    1445                 1450                 1455             


Asn Ala  Gln Thr Phe Asn Leu  Glu Gly Ser Gln Ile  Tyr Glu Asp 
    1460                 1465                 1470             


Ser Ile  Val Leu Gln Ser Val  Phe Lys Ser Ala Arg  Gln Lys Ile 
    1475                 1480                 1485             


Ala Lys  Glu Glu Glu Ser Glu  Asp Glu Ser Asn Glu  Glu Glu Glu 
    1490                 1495                 1500             


Glu Glu  Asp Glu Glu Glu Ser  Glu Ser Glu Ala Lys  Ser Val Lys 
    1505                 1510                 1515             


Val Lys  Ile Lys Leu Asn Lys  Lys Asp Asp Lys Gly  Arg Asp Lys 
    1520                 1525                 1530             


Gly Lys  Gly Lys Lys Arg Pro  Asn Arg Gly Lys Ala  Lys Pro Val 
    1535                 1540                 1545             


Val Ser  Asp Phe Asp Ser Asp  Glu Glu Gln Asp Glu  Arg Glu Gln 
    1550                 1555                 1560             


Ser Glu  Gly Ser Gly Thr Asp  Asp Glu 
    1565                 1570         


<210> 176
<211> 5838
<212> DNA
<213> Homo sapiens

<400> 176
gcgtcttccg gcgcccgcgg aggaggcgag ggtgggacgc tgggcggagc ccgagtttag       60

gaagaggagg ggacggctgt catcaatgaa gtcatattca taatctagtc ctctctccct      120

ctgtttctgt actctgggtg actcagagag ggaagagatt cagccagcac actcctcgcg      180

agcaagcatt actctactga ctggcagaga caggagaggt agatgtccac gcccacagac      240

cctggtgcga tgccccaccc agggccttcg ccggggcctg ggccttcccc tgggccaatt      300

cttgggccta gtccaggacc aggaccatcc ccaggttccg tccacagcat gatggggcca      360

agtcctggac ctccaagtgt ctcccatcct atgccgacga tggggtccac agacttccca      420

caggaaggca tgcatcaaat gcataagccc atcgatggta tacatgacaa ggggattgta      480

gaagacatcc attgtggatc catgaagggc actggtatgc gaccacctca cccaggcatg      540

ggccctcccc agagtccaat ggatcaacac agccaaggtt atatgtcacc acacccatct      600

ccattaggag ccccagagca cgtctccagc cctatgtctg gaggaggccc aactccacct      660

cagatgccac caagccagcc gggggccctc atcccaggtg atccgcaggc catgagccag      720

cccaacagag gtccctcacc tttcagtcct gtccagctgc atcagcttcg agctcagatt      780

ttagcttata aaatgctggc ccgaggccag cccctccccg aaacgctgca gcttgcagtc      840

caggggaaaa ggacgttgcc tggcttgcag caacaacagc agcagcaaca gcagcagcag      900

cagcagcagc agcagcagca gcagcagcaa cagcagccgc agcagcagcc gccgcaacca      960

cagacgcagc aacaacagca gccggccctt gttaactaca acagaccatc tggcccgggg     1020

ccggagctga gcggcccgag caccccgcag aagctgccgg tgcccgcgcc cggcggccgg     1080

ccctcgcccg cgccccccgc agccgcgcag ccgcccgcgg ccgcagtgcc cgggccctca     1140

gtgccgcagc cggccccggg gcagccctcg cccgtcctcc agctgcagca gaagcagagc     1200

cgcatcagcc ccatccagaa accgcaaggc ctggaccccg tggaaattct gcaagagcgg     1260

gaatacagac ttcaggcccg catagctcat aggatacaag aactggaaaa tctgcctggc     1320

tctttgccac cagatttaag aaccaaagca accgtggaac taaaagcact tcggttactc     1380

aatttccagc gtcagctgag acaggaggtg gtggcctgca tgcgcaggga cacgaccctg     1440

gagacggctc tcaactccaa agcatacaaa cggagcaagc gccagactct gagagaagct     1500

cgcatgaccg agaagctgga gaagcagcag aagattgagc aggagaggaa acgccgtcag     1560

aaacaccagg aatacctgaa cagtattttg caacatgcaa aagattttaa ggaatatcat     1620

cggtctgtgg ccggaaagat ccagaagctc tccaaagcag tggcaacttg gcatgccaac     1680

actgaaagag agcagaagaa ggagacagag cggattgaaa aggagagaat gcggcgactg     1740

atggctgaag atgaggaggg ttatagaaaa ctgattgatc aaaagaaaga caggcgttta     1800

gcttaccttt tgcagcagac cgatgagtat gtagccaatc tgaccaatct ggtttgggag     1860

cacaagcaag cccaggcagc caaagagaag aagaagagga ggaggaggaa gaagaaggct     1920

gaggagaatg cagagggtgg ggagtctgcc ctgggaccgg atggagagcc catagatgag     1980

agcagccaga tgagtgacct ccctgtcaaa gtgactcaca cagaaaccgg caaggttctg     2040

ttcggaccag aagcacccaa agcaagtcag ctggacgcct ggctggaaat gaatcctggt     2100

tatgaagttg cccctagatc tgacagtgaa gagagtgatt ctgattatga ggaagaggat     2160

gaggaagaag agtccagtag gcaggaaacc gaagagaaaa tactcctgga tccaaatagc     2220

gaagaagttt ctgagaagga tgctaagcag atcattgaga cagctaagca agacgtggat     2280

gatgaataca gcatgcagta cagtgccagg ggctcccagt cctactacac cgtggctcat     2340

gccatctcgg agagggtgga gaaacagtct gccctcctaa ttaatgggac cctaaagcat     2400

taccagctcc agggcctgga atggatggtt tccctgtata ataacaactt gaacggaatc     2460

ttagccgatg aaatggggct tggaaagacc atacagacca ttgcactcat cacttatctg     2520

atggagcaca aaagactcaa tggcccctat ctcatcattg ttcccctttc gactctatct     2580

aactggacat atgaatttga caaatgggct ccttctgtgg tgaagatttc ttacaagggt     2640

actcctgcca tgcgtcgctc ccttgtcccc cagctacgga gtggcaaatt caatgtcctc     2700

ttgactactt atgagtatat tataaaagac aagcacattc ttgcaaagat tcggtggaaa     2760

tacatgatag tggacgaagg ccaccgaatg aagaatcacc actgcaagct gactcaggtc     2820

ttgaacactc actatgtggc ccccagaagg atcctcttga ctgggacccc gctgcagaat     2880

aagctccctg aactctgggc cctcctcaac ttcctcctcc caacaatttt taagagctgc     2940

agcacatttg aacaatggtt caatgctcca tttgccatga ctggtgaaag ggtggactta     3000

aatgaagaag aaactatatt gatcatcagg cgtctacata aggtgttaag accattttta     3060

ctaaggagac tgaagaaaga agttgaatcc cagcttcccg aaaaagtgga atatgtgatc     3120

aagtgtgaca tgtcagctct gcagaagatt ctgtatcgcc atatgcaagc caaggggatc     3180

cttctcacag atggttctga gaaagataag aaggggaaag gaggtgctaa gacacttatg     3240

aacactatta tgcagttgag aaaaatctgc aaccacccat atatgtttca gcacattgag     3300

gaatcctttg ctgaacacct aggctattca aatggggtca tcaatggggc tgaactgtat     3360

cgggcctcag ggaagtttga gctgcttgat cgtattctgc caaaattgag agcgactaat     3420

caccgagtgc tgcttttctg ccagatgaca tctctcatga ccatcatgga ggattatttt     3480

gcttttcgga acttccttta cctacgcctt gatggcacca ccaagtctga agatcgtgct     3540

gctttgctga agaaattcaa tgaacctgga tcccagtatt tcattttctt gctgagcaca     3600

agagctggtg gcctgggctt aaatcttcag gcagctgata cagtggtcat ctttgacagc     3660

gactggaatc ctcatcagga tctgcaggcc caagaccgag ctcaccgcat cgggcagcag     3720

aacgaggtcc gggtactgag gctctgtacc gtgaacagcg tggaggaaaa gatcctcgcg     3780

gccgcaaaat acaagctgaa cgtggatcag aaagtgatcc aggcgggcat gtttgaccaa     3840

aagtcttcaa gccacgagcg gagggcattc ctgcaggcca tcttggagca tgaggaggaa     3900

aatgaggaag aagatgaagt accggacgat gagactctga accaaatgat tgctcgacga     3960

gaagaagaat ttgacctttt tatgcggatg gacatggacc ggcggaggga agatgcccgg     4020

aacccgaaac ggaagccccg tttaatggag gaggatgagc tgccctcctg gatcattaag     4080

gatgacgctg aagtagaaag gctcacctgt gaagaagagg aggagaaaat atttgggagg     4140

gggtcccgcc agcgccgtga cgtggactac agtgacgccc tcacggagaa gcagtggcta     4200

agggccatcg aagacggcaa tttggaggaa atggaagagg aagtacggct taagaagcga     4260

aaaagacgaa gaaatgtgga taaagatcct gcaaaagaag atgtggaaaa agctaagaag     4320

agaagaggcc gccctcccgc tgagaaactg tcaccaaatc cccccaaact gacaaagcag     4380

atgaacgcta tcatcgatac tgtgataaac tacaaagata gttcagggcg acagctcagt     4440

gaagtcttca ttcagttacc ttcaaggaaa gaattaccag aatactatga attaattagg     4500

aagccagtgg atttcaaaaa aataaaggaa aggattcgta atcataagta ccggagccta     4560

ggcgacctgg agaaggatgt catgcttctc tgtcacaacg ctcagacgtt caacctggag     4620

ggatcccaga tctatgaaga ctccatcgtc ttacagtcag tgtttaagag tgcccggcag     4680

aaaattgcca aagaggaaga gagtgaggat gaaagcaatg aagaggagga agaggaagat     4740

gaagaagagt cagagtccga ggcaaaatca gtcaaggtga aaattaagct caataaaaaa     4800

gatgacaaag gccgggacaa agggaaaggc aagaaaaggc caaatcgagg aaaagccaaa     4860

cctgtagtga gcgattttga cagcgatgag gagcaggatg aacgtgaaca gtcagaagga     4920

agtgggacgg atgatgagtg atcagtatgg acctttttcc ttggtagaac tgaattcctt     4980

cctcccctgt ctcatttcta cccagtgagt tcatttgtca tataggcact gggttgtttc     5040

tatatcatca tcgtctataa actagcttta ggatagtgcc agacaaacat atgatatcat     5100

ggtgtaaaaa acacacacat acacaaatat ttgtaacata ttgtgaccaa atgggcctca     5160

aagattcaga ttgaaacaaa caaaaagctt ttgatggaaa atatgtgggt ggatagtata     5220

tttctatggg tgggtctaat ttggtaacgg tttgattgtg cctggtttta tcacctgttc     5280

agatgagaag atttttgtct tttgtagcac tgataaccag gagaagccat taaaagccac     5340

tggttatttt atttttcatc aggcaatttt cgaggttttt atttgttcgg tattgttttt     5400

ttacactgtg gtacatataa gcaactttaa taggtgataa atgtacagta gttagatttc     5460

acctgcatat acatttttcc attttatgct ctatgatctg aacaaaagct ttttgaattg     5520

tataagattt atgtctactg taaacattgc ttaatttttt tgctcttgat ttaaaaaaaa     5580

gttttgttga aagcgctatt gaatattgca atctatatag tgtattggat ggcttctttt     5640

gtcaccctga tctcctatgt taccaatgtg tatcgtctcc ttctccctaa agtgtactta     5700

atctttgctt tctttgcaca atgtctttgg ttgcaagtca taagcctgag gcaaataaaa     5760

ttccagtaat ttcgaagaat gtggtgttgg tgctttccta ataaagaaat aatttagctt     5820

gacaaaaaaa aaaaaaaa                                                   5838


<210> 177
<211> 1514
<212> PRT
<213> Homo sapiens

<400> 177
Met Ser Thr Pro Thr Asp Pro Gly Ala Met Pro His Pro Gly Pro Ser 
1               5                   10                  15      


Pro Gly Pro Gly Pro Ser Pro Gly Pro Ile Leu Gly Pro Ser Pro Gly 
            20                  25                  30          


Pro Gly Pro Ser Pro Gly Ser Val His Ser Met Met Gly Pro Ser Pro 
        35                  40                  45              


Gly Pro Pro Ser Val Ser His Pro Met Pro Thr Met Gly Ser Thr Asp 
    50                  55                  60                  


Phe Pro Gln Glu Gly Met His Gln Met His Lys Pro Ile Asp Gly Ile 
65                  70                  75                  80  


His Asp Lys Gly Ile Val Glu Asp Ile His Cys Gly Ser Met Lys Gly 
                85                  90                  95      


Thr Gly Met Arg Pro Pro His Pro Gly Met Gly Pro Pro Gln Ser Pro 
            100                 105                 110         


Met Asp Gln His Ser Gln Gly Tyr Met Ser Pro His Pro Ser Pro Leu 
        115                 120                 125             


Gly Ala Pro Glu His Val Ser Ser Pro Met Ser Gly Gly Gly Pro Thr 
    130                 135                 140                 


Pro Pro Gln Met Pro Pro Ser Gln Pro Gly Ala Leu Ile Pro Gly Asp 
145                 150                 155                 160 


Pro Gln Ala Met Ser Gln Pro Asn Arg Gly Pro Ser Pro Phe Ser Pro 
                165                 170                 175     


Val Gln Leu His Gln Leu Arg Ala Gln Ile Leu Ala Tyr Lys Met Leu 
            180                 185                 190         


Ala Arg Gly Gln Pro Leu Pro Glu Thr Leu Gln Leu Ala Val Gln Gly 
        195                 200                 205             


Lys Arg Thr Leu Pro Gly Leu Gln Gln Gln Gln Gln Gln Gln Gln Gln 
    210                 215                 220                 


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Pro Gln 
225                 230                 235                 240 


Gln Gln Pro Pro Gln Pro Gln Thr Gln Gln Gln Gln Gln Pro Ala Leu 
                245                 250                 255     


Val Asn Tyr Asn Arg Pro Ser Gly Pro Gly Pro Glu Leu Ser Gly Pro 
            260                 265                 270         


Ser Thr Pro Gln Lys Leu Pro Val Pro Ala Pro Gly Gly Arg Pro Ser 
        275                 280                 285             


Pro Ala Pro Pro Ala Ala Ala Gln Pro Pro Ala Ala Ala Val Pro Gly 
    290                 295                 300                 


Pro Ser Val Pro Gln Pro Ala Pro Gly Gln Pro Ser Pro Val Leu Gln 
305                 310                 315                 320 


Leu Gln Gln Lys Gln Ser Arg Ile Ser Pro Ile Gln Lys Pro Gln Gly 
                325                 330                 335     


Leu Asp Pro Val Glu Ile Leu Gln Glu Arg Glu Tyr Arg Leu Gln Ala 
            340                 345                 350         


Arg Ile Ala His Arg Ile Gln Glu Leu Glu Asn Leu Pro Gly Ser Leu 
        355                 360                 365             


Pro Pro Asp Leu Arg Thr Lys Ala Thr Val Glu Leu Lys Ala Leu Arg 
    370                 375                 380                 


Leu Leu Asn Phe Gln Arg Gln Leu Arg Gln Glu Val Val Ala Cys Met 
385                 390                 395                 400 


Arg Arg Asp Thr Thr Leu Glu Thr Ala Leu Asn Ser Lys Ala Tyr Lys 
                405                 410                 415     


Arg Ser Lys Arg Gln Thr Leu Arg Glu Ala Arg Met Thr Glu Lys Leu 
            420                 425                 430         


Glu Lys Gln Gln Lys Ile Glu Gln Glu Arg Lys Arg Arg Gln Lys His 
        435                 440                 445             


Gln Glu Tyr Leu Asn Ser Ile Leu Gln His Ala Lys Asp Phe Lys Glu 
    450                 455                 460                 


Tyr His Arg Ser Val Ala Gly Lys Ile Gln Lys Leu Ser Lys Ala Val 
465                 470                 475                 480 


Ala Thr Trp His Ala Asn Thr Glu Arg Glu Gln Lys Lys Glu Thr Glu 
                485                 490                 495     


Arg Ile Glu Lys Glu Arg Met Arg Arg Leu Met Ala Glu Asp Glu Glu 
            500                 505                 510         


Gly Tyr Arg Lys Leu Ile Asp Gln Lys Lys Asp Arg Arg Leu Ala Tyr 
        515                 520                 525             


Leu Leu Gln Gln Thr Asp Glu Tyr Val Ala Asn Leu Thr Asn Leu Val 
    530                 535                 540                 


Trp Glu His Lys Gln Ala Gln Ala Ala Lys Glu Lys Lys Lys Arg Arg 
545                 550                 555                 560 


Arg Arg Lys Lys Lys Ala Glu Glu Asn Ala Glu Gly Gly Glu Ser Ala 
                565                 570                 575     


Leu Gly Pro Asp Gly Glu Pro Ile Asp Glu Ser Ser Gln Met Ser Asp 
            580                 585                 590         


Leu Pro Val Lys Val Thr His Thr Glu Thr Gly Lys Val Leu Phe Gly 
        595                 600                 605             


Pro Glu Ala Pro Lys Ala Ser Gln Leu Asp Ala Trp Leu Glu Met Asn 
    610                 615                 620                 


Pro Gly Tyr Glu Val Ala Pro Arg Ser Asp Ser Glu Glu Ser Asp Ser 
625                 630                 635                 640 


Asp Tyr Glu Glu Glu Asp Glu Glu Glu Glu Ser Ser Arg Gln Glu Thr 
                645                 650                 655     


Glu Glu Lys Ile Leu Leu Asp Pro Asn Ser Glu Glu Val Ser Glu Lys 
            660                 665                 670         


Asp Ala Lys Gln Ile Ile Glu Thr Ala Lys Gln Asp Val Asp Asp Glu 
        675                 680                 685             


Tyr Ser Met Gln Tyr Ser Ala Arg Gly Ser Gln Ser Tyr Tyr Thr Val 
    690                 695                 700                 


Ala His Ala Ile Ser Glu Arg Val Glu Lys Gln Ser Ala Leu Leu Ile 
705                 710                 715                 720 


Asn Gly Thr Leu Lys His Tyr Gln Leu Gln Gly Leu Glu Trp Met Val 
                725                 730                 735     


Ser Leu Tyr Asn Asn Asn Leu Asn Gly Ile Leu Ala Asp Glu Met Gly 
            740                 745                 750         


Leu Gly Lys Thr Ile Gln Thr Ile Ala Leu Ile Thr Tyr Leu Met Glu 
        755                 760                 765             


His Lys Arg Leu Asn Gly Pro Tyr Leu Ile Ile Val Pro Leu Ser Thr 
    770                 775                 780                 


Leu Ser Asn Trp Thr Tyr Glu Phe Asp Lys Trp Ala Pro Ser Val Val 
785                 790                 795                 800 


Lys Ile Ser Tyr Lys Gly Thr Pro Ala Met Arg Arg Ser Leu Val Pro 
                805                 810                 815     


Gln Leu Arg Ser Gly Lys Phe Asn Val Leu Leu Thr Thr Tyr Glu Tyr 
            820                 825                 830         


Ile Ile Lys Asp Lys His Ile Leu Ala Lys Ile Arg Trp Lys Tyr Met 
        835                 840                 845             


Ile Val Asp Glu Gly His Arg Met Lys Asn His His Cys Lys Leu Thr 
    850                 855                 860                 


Gln Val Asp Leu Asn Glu Glu Glu Thr Ile Leu Ile Ile Arg Arg Leu 
865                 870                 875                 880 


His Lys Val Leu Arg Pro Phe Leu Leu Arg Arg Leu Lys Lys Glu Val 
                885                 890                 895     


Glu Ser Gln Leu Pro Glu Lys Val Glu Tyr Val Ile Lys Cys Asp Met 
            900                 905                 910         


Ser Ala Leu Gln Lys Ile Leu Tyr Arg His Met Gln Ala Lys Gly Ile 
        915                 920                 925             


Leu Leu Thr Asp Gly Ser Glu Lys Asp Lys Lys Gly Lys Gly Gly Ala 
    930                 935                 940                 


Lys Thr Leu Met Asn Thr Ile Met Gln Leu Arg Lys Ile Cys Asn His 
945                 950                 955                 960 


Pro Tyr Met Phe Gln His Ile Glu Glu Ser Phe Ala Glu His Leu Gly 
                965                 970                 975     


Tyr Ser Asn Gly Val Ile Asn Gly Ala Glu Leu Tyr Arg Ala Ser Gly 
            980                 985                 990         


Lys Phe Glu Leu Leu Asp Arg Ile  Leu Pro Lys Leu Arg  Ala Thr Asn 
        995                 1000                 1005             


His Arg  Val Leu Leu Phe Cys  Gln Met Thr Ser Leu  Met Thr Ile 
    1010                 1015                 1020             


Met Glu  Asp Tyr Phe Ala Phe  Arg Asn Phe Leu Tyr  Leu Arg Leu 
    1025                 1030                 1035             


Asp Gly  Thr Thr Lys Ser Glu  Asp Arg Ala Ala Leu  Leu Lys Lys 
    1040                 1045                 1050             


Phe Asn  Glu Pro Gly Ser Gln  Tyr Phe Ile Phe Leu  Leu Ser Thr 
    1055                 1060                 1065             


Arg Ala  Gly Gly Leu Gly Leu  Asn Leu Gln Ala Ala  Asp Thr Val 
    1070                 1075                 1080             


Val Ile  Phe Asp Ser Asp Trp  Asn Pro His Gln Asp  Leu Gln Ala 
    1085                 1090                 1095             


Gln Asp  Arg Ala His Arg Ile  Gly Gln Gln Asn Glu  Val Arg Val 
    1100                 1105                 1110             


Leu Arg  Leu Cys Thr Val Asn  Ser Val Glu Glu Lys  Ile Leu Ala 
    1115                 1120                 1125             


Ala Ala  Lys Tyr Lys Leu Asn  Val Asp Gln Lys Val  Ile Gln Ala 
    1130                 1135                 1140             


Gly Met  Phe Asp Gln Lys Ser  Ser Ser His Glu Arg  Arg Ala Phe 
    1145                 1150                 1155             


Leu Gln  Ala Ile Leu Glu His  Glu Glu Glu Asn Glu  Glu Glu Asp 
    1160                 1165                 1170             


Glu Val  Pro Asp Asp Glu Thr  Leu Asn Gln Met Ile  Ala Arg Arg 
    1175                 1180                 1185             


Glu Glu  Glu Phe Asp Leu Phe  Met Arg Met Asp Met  Asp Arg Arg 
    1190                 1195                 1200             


Arg Glu  Asp Ala Arg Asn Pro  Lys Arg Lys Pro Arg  Leu Met Glu 
    1205                 1210                 1215             


Glu Asp  Glu Leu Pro Ser Trp  Ile Ile Lys Asp Asp  Ala Glu Val 
    1220                 1225                 1230             


Glu Arg  Leu Thr Cys Glu Glu  Glu Glu Glu Lys Ile  Phe Gly Arg 
    1235                 1240                 1245             


Gly Ser  Arg Gln Arg Arg Asp  Val Asp Tyr Ser Asp  Ala Leu Thr 
    1250                 1255                 1260             


Glu Lys  Gln Trp Leu Arg Ala  Ile Glu Asp Gly Asn  Leu Glu Glu 
    1265                 1270                 1275             


Met Glu  Glu Glu Val Arg Leu  Lys Lys Arg Lys Arg  Arg Arg Asn 
    1280                 1285                 1290             


Val Asp  Lys Asp Pro Ala Lys  Glu Asp Val Glu Lys  Ala Lys Lys 
    1295                 1300                 1305             


Arg Arg  Gly Arg Pro Pro Ala  Glu Lys Leu Ser Pro  Asn Pro Pro 
    1310                 1315                 1320             


Lys Leu  Thr Lys Gln Met Asn  Ala Ile Ile Asp Thr  Val Ile Asn 
    1325                 1330                 1335             


Tyr Lys  Asp Ser Ser Gly Arg  Gln Leu Ser Glu Val  Phe Ile Gln 
    1340                 1345                 1350             


Leu Pro  Ser Arg Lys Glu Leu  Pro Glu Tyr Tyr Glu  Leu Ile Arg 
    1355                 1360                 1365             


Lys Pro  Val Asp Phe Lys Lys  Ile Lys Glu Arg Ile  Arg Asn His 
    1370                 1375                 1380             


Lys Tyr  Arg Ser Leu Gly Asp  Leu Glu Lys Asp Val  Met Leu Leu 
    1385                 1390                 1395             


Cys His  Asn Ala Gln Thr Phe  Asn Leu Glu Gly Ser  Gln Ile Tyr 
    1400                 1405                 1410             


Glu Asp  Ser Ile Val Leu Gln  Ser Val Phe Lys Ser  Ala Arg Gln 
    1415                 1420                 1425             


Lys Ile  Ala Lys Glu Glu Glu  Ser Glu Asp Glu Ser  Asn Glu Glu 
    1430                 1435                 1440             


Glu Glu  Glu Glu Asp Glu Glu  Glu Ser Glu Ser Glu  Ala Lys Ser 
    1445                 1450                 1455             


Val Lys  Val Lys Ile Lys Leu  Asn Lys Lys Asp Asp  Lys Gly Arg 
    1460                 1465                 1470             


Asp Lys  Gly Lys Gly Lys Lys  Arg Pro Asn Arg Gly  Lys Ala Lys 
    1475                 1480                 1485             


Pro Val  Val Ser Asp Phe Asp  Ser Asp Glu Glu Gln  Asp Glu Arg 
    1490                 1495                 1500             


Glu Gln  Ser Glu Gly Ser Gly  Thr Asp Asp Glu 
    1505                 1510                 


<210> 178
<211> 5664
<212> DNA
<213> Homo sapiens

<400> 178
gcgtcttccg gcgcccgcgg aggaggcgag ggtgggacgc tgggcggagc ccgagtttag       60

gaagaggagg ggacggctgt catcaatgaa gtcatattca taatctagtc ctctctccct      120

ctgtttctgt actctgggtg actcagagag ggaagagatt cagccagcac actcctcgcg      180

agcaagcatt actctactga ctggcagaga caggagaggt agatgtccac gcccacagac      240

cctggtgcga tgccccaccc agggccttcg ccggggcctg ggccttcccc tgggccaatt      300

cttgggccta gtccaggacc aggaccatcc ccaggttccg tccacagcat gatggggcca      360

agtcctggac ctccaagtgt ctcccatcct atgccgacga tggggtccac agacttccca      420

caggaaggca tgcatcaaat gcataagccc atcgatggta tacatgacaa ggggattgta      480

gaagacatcc attgtggatc catgaagggc actggtatgc gaccacctca cccaggcatg      540

ggccctcccc agagtccaat ggatcaacac agccaaggtt atatgtcacc acacccatct      600

ccattaggag ccccagagca cgtctccagc cctatgtctg gaggaggccc aactccacct      660

cagatgccac caagccagcc gggggccctc atcccaggtg atccgcaggc catgagccag      720

cccaacagag gtccctcacc tttcagtcct gtccagctgc atcagcttcg agctcagatt      780

ttagcttata aaatgctggc ccgaggccag cccctccccg aaacgctgca gcttgcagtc      840

caggggaaaa ggacgttgcc tggcttgcag caacaacagc agcagcaaca gcagcagcag      900

cagcagcagc agcagcagca gcagcagcaa cagcagccgc agcagcagcc gccgcaacca      960

cagacgcagc aacaacagca gccggccctt gttaactaca acagaccatc tggcccgggg     1020

ccggagctga gcggcccgag caccccgcag aagctgccgg tgcccgcgcc cggcggccgg     1080

ccctcgcccg cgccccccgc agccgcgcag ccgcccgcgg ccgcagtgcc cgggccctca     1140

gtgccgcagc cggccccggg gcagccctcg cccgtcctcc agctgcagca gaagcagagc     1200

cgcatcagcc ccatccagaa accgcaaggc ctggaccccg tggaaattct gcaagagcgg     1260

gaatacagac ttcaggcccg catagctcat aggatacaag aactggaaaa tctgcctggc     1320

tctttgccac cagatttaag aaccaaagca accgtggaac taaaagcact tcggttactc     1380

aatttccagc gtcagctgag acaggaggtg gtggcctgca tgcgcaggga cacgaccctg     1440

gagacggctc tcaactccaa agcatacaaa cggagcaagc gccagactct gagagaagct     1500

cgcatgaccg agaagctgga gaagcagcag aagattgagc aggagaggaa acgccgtcag     1560

aaacaccagg aatacctgaa cagtattttg caacatgcaa aagattttaa ggaatatcat     1620

cggtctgtgg ccggaaagat ccagaagctc tccaaagcag tggcaacttg gcatgccaac     1680

actgaaagag agcagaagaa ggagacagag cggattgaaa aggagagaat gcggcgactg     1740

atggctgaag atgaggaggg ttatagaaaa ctgattgatc aaaagaaaga caggcgttta     1800

gcttaccttt tgcagcagac cgatgagtat gtagccaatc tgaccaatct ggtttgggag     1860

cacaagcaag cccaggcagc caaagagaag aagaagagga ggaggaggaa gaagaaggct     1920

gaggagaatg cagagggtgg ggagtctgcc ctgggaccgg atggagagcc catagatgag     1980

agcagccaga tgagtgacct ccctgtcaaa gtgactcaca cagaaaccgg caaggttctg     2040

ttcggaccag aagcacccaa agcaagtcag ctggacgcct ggctggaaat gaatcctggt     2100

tatgaagttg cccctagatc tgacagtgaa gagagtgatt ctgattatga ggaagaggat     2160

gaggaagaag agtccagtag gcaggaaacc gaagagaaaa tactcctgga tccaaatagc     2220

gaagaagttt ctgagaagga tgctaagcag atcattgaga cagctaagca agacgtggat     2280

gatgaataca gcatgcagta cagtgccagg ggctcccagt cctactacac cgtggctcat     2340

gccatctcgg agagggtgga gaaacagtct gccctcctaa ttaatgggac cctaaagcat     2400

taccagctcc agggcctgga atggatggtt tccctgtata ataacaactt gaacggaatc     2460

ttagccgatg aaatggggct tggaaagacc atacagacca ttgcactcat cacttatctg     2520

atggagcaca aaagactcaa tggcccctat ctcatcattg ttcccctttc gactctatct     2580

aactggacat atgaatttga caaatgggct ccttctgtgg tgaagatttc ttacaagggt     2640

actcctgcca tgcgtcgctc ccttgtcccc cagctacgga gtggcaaatt caatgtcctc     2700

ttgactactt atgagtatat tataaaagac aagcacattc ttgcaaagat tcggtggaaa     2760

tacatgatag tggacgaagg ccaccgaatg aagaatcacc actgcaagct gactcaggtg     2820

gacttaaatg aagaagaaac tatattgatc atcaggcgtc tacataaggt gttaagacca     2880

tttttactaa ggagactgaa gaaagaagtt gaatcccagc ttcccgaaaa agtggaatat     2940

gtgatcaagt gtgacatgtc agctctgcag aagattctgt atcgccatat gcaagccaag     3000

gggatccttc tcacagatgg ttctgagaaa gataagaagg ggaaaggagg tgctaagaca     3060

cttatgaaca ctattatgca gttgagaaaa atctgcaacc acccatatat gtttcagcac     3120

attgaggaat cctttgctga acacctaggc tattcaaatg gggtcatcaa tggggctgaa     3180

ctgtatcggg cctcagggaa gtttgagctg cttgatcgta ttctgccaaa attgagagcg     3240

actaatcacc gagtgctgct tttctgccag atgacatctc tcatgaccat catggaggat     3300

tattttgctt ttcggaactt cctttaccta cgccttgatg gcaccaccaa gtctgaagat     3360

cgtgctgctt tgctgaagaa attcaatgaa cctggatccc agtatttcat tttcttgctg     3420

agcacaagag ctggtggcct gggcttaaat cttcaggcag ctgatacagt ggtcatcttt     3480

gacagcgact ggaatcctca tcaggatctg caggcccaag accgagctca ccgcatcggg     3540

cagcagaacg aggtccgggt actgaggctc tgtaccgtga acagcgtgga ggaaaagatc     3600

ctcgcggccg caaaatacaa gctgaacgtg gatcagaaag tgatccaggc gggcatgttt     3660

gaccaaaagt cttcaagcca cgagcggagg gcattcctgc aggccatctt ggagcatgag     3720

gaggaaaatg aggaagaaga tgaagtaccg gacgatgaga ctctgaacca aatgattgct     3780

cgacgagaag aagaatttga cctttttatg cggatggaca tggaccggcg gagggaagat     3840

gcccggaacc cgaaacggaa gccccgttta atggaggagg atgagctgcc ctcctggatc     3900

attaaggatg acgctgaagt agaaaggctc acctgtgaag aagaggagga gaaaatattt     3960

gggagggggt cccgccagcg ccgtgacgtg gactacagtg acgccctcac ggagaagcag     4020

tggctaaggg ccatcgaaga cggcaatttg gaggaaatgg aagaggaagt acggcttaag     4080

aagcgaaaaa gacgaagaaa tgtggataaa gatcctgcaa aagaagatgt ggaaaaagct     4140

aagaagagaa gaggccgccc tcccgctgag aaactgtcac caaatccccc caaactgaca     4200

aagcagatga acgctatcat cgatactgtg ataaactaca aagatagttc agggcgacag     4260

ctcagtgaag tcttcattca gttaccttca aggaaagaat taccagaata ctatgaatta     4320

attaggaagc cagtggattt caaaaaaata aaggaaagga ttcgtaatca taagtaccgg     4380

agcctaggcg acctggagaa ggatgtcatg cttctctgtc acaacgctca gacgttcaac     4440

ctggagggat cccagatcta tgaagactcc atcgtcttac agtcagtgtt taagagtgcc     4500

cggcagaaaa ttgccaaaga ggaagagagt gaggatgaaa gcaatgaaga ggaggaagag     4560

gaagatgaag aagagtcaga gtccgaggca aaatcagtca aggtgaaaat taagctcaat     4620

aaaaaagatg acaaaggccg ggacaaaggg aaaggcaaga aaaggccaaa tcgaggaaaa     4680

gccaaacctg tagtgagcga ttttgacagc gatgaggagc aggatgaacg tgaacagtca     4740

gaaggaagtg ggacggatga tgagtgatca gtatggacct ttttccttgg tagaactgaa     4800

ttccttcctc ccctgtctca tttctaccca gtgagttcat ttgtcatata ggcactgggt     4860

tgtttctata tcatcatcgt ctataaacta gctttaggat agtgccagac aaacatatga     4920

tatcatggtg taaaaaacac acacatacac aaatatttgt aacatattgt gaccaaatgg     4980

gcctcaaaga ttcagattga aacaaacaaa aagcttttga tggaaaatat gtgggtggat     5040

agtatatttc tatgggtggg tctaatttgg taacggtttg attgtgcctg gttttatcac     5100

ctgttcagat gagaagattt ttgtcttttg tagcactgat aaccaggaga agccattaaa     5160

agccactggt tattttattt ttcatcaggc aattttcgag gtttttattt gttcggtatt     5220

gtttttttac actgtggtac atataagcaa ctttaatagg tgataaatgt acagtagtta     5280

gatttcacct gcatatacat ttttccattt tatgctctat gatctgaaca aaagcttttt     5340

gaattgtata agatttatgt ctactgtaaa cattgcttaa tttttttgct cttgatttaa     5400

aaaaaagttt tgttgaaagc gctattgaat attgcaatct atatagtgta ttggatggct     5460

tcttttgtca ccctgatctc ctatgttacc aatgtgtatc gtctccttct ccctaaagtg     5520

tacttaatct ttgctttctt tgcacaatgt ctttggttgc aagtcataag cctgaggcaa     5580

ataaaattcc agtaatttcg aagaatgtgg tgttggtgct ttcctaataa agaaataatt     5640

tagcttgaca aaaaaaaaaa aaaa                                            5664


<210> 179
<211> 248
<212> PRT
<213> Homo sapiens

<400> 179
Met Trp Leu Ala Ile Glu Asp Gly Asn Leu Glu Glu Met Glu Glu Glu 
1               5                   10                  15      


Val Arg Leu Lys Lys Arg Lys Arg Arg Arg Asn Val Asp Lys Asp Pro 
            20                  25                  30          


Ala Lys Glu Asp Val Glu Lys Ala Lys Lys Arg Arg Gly Arg Pro Pro 
        35                  40                  45              


Ala Glu Lys Leu Ser Pro Asn Pro Pro Lys Leu Thr Lys Gln Met Asn 
    50                  55                  60                  


Ala Ile Ile Asp Thr Val Ile Asn Tyr Lys Asp Ser Ser Gly Arg Gln 
65                  70                  75                  80  


Leu Ser Glu Val Phe Ile Gln Leu Pro Ser Arg Lys Glu Leu Pro Glu 
                85                  90                  95      


Tyr Tyr Glu Leu Ile Arg Lys Pro Val Asp Phe Lys Lys Ile Lys Glu 
            100                 105                 110         


Arg Ile Arg Asn His Lys Tyr Arg Ser Leu Gly Asp Leu Glu Lys Asp 
        115                 120                 125             


Val Met Leu Leu Cys His Asn Ala Gln Thr Phe Asn Leu Glu Gly Ser 
    130                 135                 140                 


Gln Ile Tyr Glu Asp Ser Ile Val Leu Gln Ser Val Phe Lys Ser Ala 
145                 150                 155                 160 


Arg Gln Lys Ile Ala Lys Glu Glu Glu Ser Glu Asp Glu Ser Asn Glu 
                165                 170                 175     


Glu Glu Glu Glu Glu Asp Glu Glu Glu Ser Glu Ser Glu Ala Lys Ser 
            180                 185                 190         


Val Lys Val Lys Ile Lys Leu Asn Lys Lys Asp Asp Lys Gly Arg Asp 
        195                 200                 205             


Lys Gly Lys Gly Lys Lys Arg Pro Asn Arg Gly Lys Ala Lys Pro Val 
    210                 215                 220                 


Val Ser Asp Phe Asp Ser Asp Glu Glu Gln Asp Glu Arg Glu Gln Ser 
225                 230                 235                 240 


Glu Gly Ser Gly Thr Asp Asp Glu 
                245             


<210> 180
<211> 1846
<212> DNA
<213> Homo sapiens

<400> 180
cttggagagg cggaggtgga aacgatgcgc aggagttggc ttggggcttt ttgtttgcgt       60

gtccctgttt acctattcat aatcatggat cccctctgct ttgtgatact gtgaaccacg      120

cataacagca attctttaca ccaccgggtt gagaagaagg cgcctgaggc tgactttctg      180

gacctgccgt cacgcagtaa agatgtggtt ggccatcgaa gacggcaatt tggaggaaat      240

ggaagaggaa gtacggctta agaagcgaaa aagacgaaga aatgtggata aagatcctgc      300

aaaagaagat gtggaaaaag ctaagaagag aagaggccgc cctcccgctg agaaactgtc      360

accaaatccc cccaaactga caaagcagat gaacgctatc atcgatactg tgataaacta      420

caaagatagt tcagggcgac agctcagtga agtcttcatt cagttacctt caaggaaaga      480

attaccagaa tactatgaat taattaggaa gccagtggat ttcaaaaaaa taaaggaaag      540

gattcgtaat cataagtacc ggagcctagg cgacctggag aaggatgtca tgcttctctg      600

tcacaacgct cagacgttca acctggaggg atcccagatc tatgaagact ccatcgtctt      660

acagtcagtg tttaagagtg cccggcagaa aattgccaaa gaggaagaga gtgaggatga      720

aagcaatgaa gaggaggaag aggaagatga agaagagtca gagtccgagg caaaatcagt      780

caaggtgaaa attaagctca ataaaaaaga tgacaaaggc cgggacaaag ggaaaggcaa      840

gaaaaggcca aatcgaggaa aagccaaacc tgtagtgagc gattttgaca gcgatgagga      900

gcaggatgaa cgtgaacagt cagaaggaag tgggacggat gatgagtgat cagtatggac      960

ctttttcctt ggtagaactg aattccttcc tcccctgtct catttctacc cagtgagttc     1020

atttgtcata taggcactgg gttgtttcta tatcatcatc gtctataaac tagctttagg     1080

atagtgccag acaaacatat gatatcatgg tgtaaaaaac acacacatac acaaatattt     1140

gtaacatatt gtgaccaaat gggcctcaaa gattcagatt gaaacaaaca aaaagctttt     1200

gatggaaaat atgtgggtgg atagtatatt tctatgggtg ggtctaattt ggtaacggtt     1260

tgattgtgcc tggttttatc acctgttcag atgagaagat ttttgtcttt tgtagcactg     1320

ataaccagga gaagccatta aaagccactg gttattttat ttttcatcag gcaattttcg     1380

aggtttttat ttgttcggta ttgttttttt acactgtggt acatataagc aactttaata     1440

ggtgataaat gtacagtagt tagatttcac ctgcatatac atttttccat tttatgctct     1500

atgatctgaa caaaagcttt ttgaattgta taagatttat gtctactgta aacattgctt     1560

aatttttttg ctcttgattt aaaaaaaagt tttgttgaaa gcgctattga atattgcaat     1620

ctatatagtg tattggatgg cttcttttgt caccctgatc tcctatgtta ccaatgtgta     1680

tcgtctcctt ctccctaaag tgtacttaat ctttgctttc tttgcacaat gtctttggtt     1740

gcaagtcata agcctgaggc aaataaaatt ccagtaattt cgaagaatgt ggtgttggtg     1800

ctttcctaat aaagaaataa tttagcttga caaaaaaaaa aaaaaa                    1846


<210> 181
<211> 276
<212> PRT
<213> Homo sapiens

<400> 181
Met Lys Arg Leu Ala Ala Arg Cys Phe Ala Gly Leu Leu Ile Leu Ser 
1               5                   10                  15      


Pro Leu Thr Val Ile Ser Asp Ser Arg Pro Ala Asp Ser Gly Lys Ala 
            20                  25                  30          


Ile Glu Asp Gly Asn Leu Glu Glu Met Glu Glu Glu Val Arg Leu Lys 
        35                  40                  45              


Lys Arg Lys Arg Arg Arg Asn Val Asp Lys Asp Pro Ala Lys Glu Asp 
    50                  55                  60                  


Val Glu Lys Ala Lys Lys Arg Arg Gly Arg Pro Pro Ala Glu Lys Leu 
65                  70                  75                  80  


Ser Pro Asn Pro Pro Lys Leu Thr Lys Gln Met Asn Ala Ile Ile Asp 
                85                  90                  95      


Thr Val Ile Asn Tyr Lys Asp Ser Ser Gly Arg Gln Leu Ser Glu Val 
            100                 105                 110         


Phe Ile Gln Leu Pro Ser Arg Lys Glu Leu Pro Glu Tyr Tyr Glu Leu 
        115                 120                 125             


Ile Arg Lys Pro Val Asp Phe Lys Lys Ile Lys Glu Arg Ile Arg Asn 
    130                 135                 140                 


His Lys Tyr Arg Ser Leu Gly Asp Leu Glu Lys Asp Val Met Leu Leu 
145                 150                 155                 160 


Cys His Asn Ala Gln Thr Phe Asn Leu Glu Gly Ser Gln Ile Tyr Glu 
                165                 170                 175     


Asp Ser Ile Val Leu Gln Ser Val Phe Lys Ser Ala Arg Gln Lys Ile 
            180                 185                 190         


Ala Lys Glu Glu Glu Ser Glu Asp Glu Ser Asn Glu Glu Glu Glu Glu 
        195                 200                 205             


Glu Asp Glu Glu Glu Ser Glu Ser Glu Ala Lys Ser Val Lys Val Lys 
    210                 215                 220                 


Ile Lys Leu Asn Lys Lys Asp Asp Lys Gly Arg Asp Lys Gly Lys Gly 
225                 230                 235                 240 


Lys Lys Arg Pro Asn Arg Gly Lys Ala Lys Pro Val Val Ser Asp Phe 
                245                 250                 255     


Asp Ser Asp Glu Glu Gln Asp Glu Arg Glu Gln Ser Glu Gly Ser Gly 
            260                 265                 270         


Thr Asp Asp Glu 
        275     


<210> 182
<211> 1833
<212> DNA
<213> Homo sapiens

<400> 182
attcacttca ttaaatctag aggcagttga gcatgggagc cgtctgtatg ttgaattagg       60

gctcgcactc ttgcgcaaca cgtcaccagt cggaaactgg ggctgatgaa gagactagca      120

gctcgctgct ttgctggctt gttaatttta tccccactaa ctgtgatttc tgatagccgg      180

cctgctgata gtggtaaggc catcgaagac ggcaatttgg aggaaatgga agaggaagta      240

cggcttaaga agcgaaaaag acgaagaaat gtggataaag atcctgcaaa agaagatgtg      300

gaaaaagcta agaagagaag aggccgccct cccgctgaga aactgtcacc aaatcccccc      360

aaactgacaa agcagatgaa cgctatcatc gatactgtga taaactacaa agatagttca      420

gggcgacagc tcagtgaagt cttcattcag ttaccttcaa ggaaagaatt accagaatac      480

tatgaattaa ttaggaagcc agtggatttc aaaaaaataa aggaaaggat tcgtaatcat      540

aagtaccgga gcctaggcga cctggagaag gatgtcatgc ttctctgtca caacgctcag      600

acgttcaacc tggagggatc ccagatctat gaagactcca tcgtcttaca gtcagtgttt      660

aagagtgccc ggcagaaaat tgccaaagag gaagagagtg aggatgaaag caatgaagag      720

gaggaagagg aagatgaaga agagtcagag tccgaggcaa aatcagtcaa ggtgaaaatt      780

aagctcaata aaaaagatga caaaggccgg gacaaaggga aaggcaagaa aaggccaaat      840

cgaggaaaag ccaaacctgt agtgagcgat tttgacagcg atgaggagca ggatgaacgt      900

gaacagtcag aaggaagtgg gacggatgat gagtgatcag tatggacctt tttccttggt      960

agaactgaat tccttcctcc cctgtctcat ttctacccag tgagttcatt tgtcatatag     1020

gcactgggtt gtttctatat catcatcgtc tataaactag ctttaggata gtgccagaca     1080

aacatatgat atcatggtgt aaaaaacaca cacatacaca aatatttgta acatattgtg     1140

accaaatggg cctcaaagat tcagattgaa acaaacaaaa agcttttgat ggaaaatatg     1200

tgggtggata gtatatttct atgggtgggt ctaatttggt aacggtttga ttgtgcctgg     1260

ttttatcacc tgttcagatg agaagatttt tgtcttttgt agcactgata accaggagaa     1320

gccattaaaa gccactggtt attttatttt tcatcaggca attttcgagg tttttatttg     1380

ttcggtattg tttttttaca ctgtggtaca tataagcaac tttaataggt gataaatgta     1440

cagtagttag atttcacctg catatacatt tttccatttt atgctctatg atctgaacaa     1500

aagctttttg aattgtataa gatttatgtc tactgtaaac attgcttaat ttttttgctc     1560

ttgatttaaa aaaaagtttt gttgaaagcg ctattgaata ttgcaatcta tatagtgtat     1620

tggatggctt cttttgtcac cctgatctcc tatgttacca atgtgtatcg tctccttctc     1680

cctaaagtgt acttaatctt tgctttcttt gcacaatgtc tttggttgca agtcataagc     1740

ctgaggcaaa taaaattcca gtaatttcga agaatgtggt gttggtgctt tcctaataaa     1800

gaaataattt agcttgacaa aaaaaaaaaa aaa                                  1833


<210> 183
<211> 278
<212> PRT
<213> Homo sapiens

<400> 183
Met Leu Met Lys Arg Leu Ala Ala Arg Cys Phe Ala Gly Leu Leu Ile 
1               5                   10                  15      


Leu Ser Pro Leu Thr Val Ile Ser Asp Ser Arg Pro Ala Asp Ser Gly 
            20                  25                  30          


Lys Ala Ile Glu Asp Gly Asn Leu Glu Glu Met Glu Glu Glu Val Arg 
        35                  40                  45              


Leu Lys Lys Arg Lys Arg Arg Arg Asn Val Asp Lys Asp Pro Ala Lys 
    50                  55                  60                  


Glu Asp Val Glu Lys Ala Lys Lys Arg Arg Gly Arg Pro Pro Ala Glu 
65                  70                  75                  80  


Lys Leu Ser Pro Asn Pro Pro Lys Leu Thr Lys Gln Met Asn Ala Ile 
                85                  90                  95      


Ile Asp Thr Val Ile Asn Tyr Lys Asp Ser Ser Gly Arg Gln Leu Ser 
            100                 105                 110         


Glu Val Phe Ile Gln Leu Pro Ser Arg Lys Glu Leu Pro Glu Tyr Tyr 
        115                 120                 125             


Glu Leu Ile Arg Lys Pro Val Asp Phe Lys Lys Ile Lys Glu Arg Ile 
    130                 135                 140                 


Arg Asn His Lys Tyr Arg Ser Leu Gly Asp Leu Glu Lys Asp Val Met 
145                 150                 155                 160 


Leu Leu Cys His Asn Ala Gln Thr Phe Asn Leu Glu Gly Ser Gln Ile 
                165                 170                 175     


Tyr Glu Asp Ser Ile Val Leu Gln Ser Val Phe Lys Ser Ala Arg Gln 
            180                 185                 190         


Lys Ile Ala Lys Glu Glu Glu Ser Glu Asp Glu Ser Asn Glu Glu Glu 
        195                 200                 205             


Glu Glu Glu Asp Glu Glu Glu Ser Glu Ser Glu Ala Lys Ser Val Lys 
    210                 215                 220                 


Val Lys Ile Lys Leu Asn Lys Lys Asp Asp Lys Gly Arg Asp Lys Gly 
225                 230                 235                 240 


Lys Gly Lys Lys Arg Pro Asn Arg Gly Lys Ala Lys Pro Val Val Ser 
                245                 250                 255     


Asp Phe Asp Ser Asp Glu Glu Gln Asp Glu Arg Glu Gln Ser Glu Gly 
            260                 265                 270         


Ser Gly Thr Asp Asp Glu 
        275             


<210> 184
<211> 2254
<212> DNA
<213> Homo sapiens

<400> 184
acttcattaa atctagaggc agttgagcat gggagccgtc tgtatgttga attagggctc       60

gcactcttgc gcaacacgtc accagtcgga aactgggggt ttgcttctgt gatttatttc      120

attattgtgc tggtaaaagg tttggaaggg aattcttttt gggggtagta ctttagcatt      180

gtgtagcaag ttttggggtt ttttttgtgt gtgacccccc agcccccagc gctgagtttg      240

agtcagttga gccagtttag taaataattt tttaaaataa aagaacagtt taaaatctcc      300

atgaataatt ttacttacat gcaggagtaa tcttactcta ctctttatgt gcgaaaagca      360

ttgggaagtg tttagtgaat tgatttccat tagaaaaaga cccttagaaa tcacagaaca      420

taaagcactg catatggatg tgtttggggt ctttggggag gagggaagat gttttgtagc      480

tctctgcatt cctgcataaa accttagttt gaggggaata atgctgatga agagactagc      540

agctcgctgc tttgctggct tgttaatttt atccccacta actgtgattt ctgatagccg      600

gcctgctgat agtggtaagg ccatcgaaga cggcaatttg gaggaaatgg aagaggaagt      660

acggcttaag aagcgaaaaa gacgaagaaa tgtggataaa gatcctgcaa aagaagatgt      720

ggaaaaagct aagaagagaa gaggccgccc tcccgctgag aaactgtcac caaatccccc      780

caaactgaca aagcagatga acgctatcat cgatactgtg ataaactaca aagatagttc      840

agggcgacag ctcagtgaag tcttcattca gttaccttca aggaaagaat taccagaata      900

ctatgaatta attaggaagc cagtggattt caaaaaaata aaggaaagga ttcgtaatca      960

taagtaccgg agcctaggcg acctggagaa ggatgtcatg cttctctgtc acaacgctca     1020

gacgttcaac ctggagggat cccagatcta tgaagactcc atcgtcttac agtcagtgtt     1080

taagagtgcc cggcagaaaa ttgccaaaga ggaagagagt gaggatgaaa gcaatgaaga     1140

ggaggaagag gaagatgaag aagagtcaga gtccgaggca aaatcagtca aggtgaaaat     1200

taagctcaat aaaaaagatg acaaaggccg ggacaaaggg aaaggcaaga aaaggccaaa     1260

tcgaggaaaa gccaaacctg tagtgagcga ttttgacagc gatgaggagc aggatgaacg     1320

tgaacagtca gaaggaagtg ggacggatga tgagtgatca gtatggacct ttttccttgg     1380

tagaactgaa ttccttcctc ccctgtctca tttctaccca gtgagttcat ttgtcatata     1440

ggcactgggt tgtttctata tcatcatcgt ctataaacta gctttaggat agtgccagac     1500

aaacatatga tatcatggtg taaaaaacac acacatacac aaatatttgt aacatattgt     1560

gaccaaatgg gcctcaaaga ttcagattga aacaaacaaa aagcttttga tggaaaatat     1620

gtgggtggat agtatatttc tatgggtggg tctaatttgg taacggtttg attgtgcctg     1680

gttttatcac ctgttcagat gagaagattt ttgtcttttg tagcactgat aaccaggaga     1740

agccattaaa agccactggt tattttattt ttcatcaggc aattttcgag gtttttattt     1800

gttcggtatt gtttttttac actgtggtac atataagcaa ctttaatagg tgataaatgt     1860

acagtagtta gatttcacct gcatatacat ttttccattt tatgctctat gatctgaaca     1920

aaagcttttt gaattgtata agatttatgt ctactgtaaa cattgcttaa tttttttgct     1980

cttgatttaa aaaaaagttt tgttgaaagc gctattgaat attgcaatct atatagtgta     2040

ttggatggct tcttttgtca ccctgatctc ctatgttacc aatgtgtatc gtctccttct     2100

ccctaaagtg tacttaatct ttgctttctt tgcacaatgt ctttggttgc aagtcataag     2160

cctgaggcaa ataaaattcc agtaatttcg aagaatgtgg tgttggtgct ttcctaataa     2220

agaaataatt tagcttgaca aaaaaaaaaa aaaa                                 2254


<210> 185
<211> 5831
<212> DNA
<213> Mus musculus

<400> 185
ctcgctccct ctgtttctgt actctgggtg actcagagag ggaagattca gccagcacac       60

tgctcgcgag caagtgtcac tctgctaact ggcagagcca ggagacctag atgtccacac      120

ccacagaccc agcagcaatg ccccatcctg ggccctcccc ggggcctgga ccctctcctg      180

gaccaattct ggggcctagt ccaggaccag gaccatcccc aggttctgtg cacagcatga      240

tgggtcctag tcccggacct cccagcgtct cacatcctct gtcaacgatg ggctctgcag      300

acttcccaca ggaaggcatg caccaattac ataagcccat ggatgggata catgacaaag      360

ggattgtaga agatgtccac tgtggatcca tgaagggcac cagcatgcgc cccccacacc      420

caggaatggg ccctccacag agccccatgg accagcacag ccaaggttat atgtcaccac      480

atccgtctcc tctgggagcc ccggagcacg tctctagccc tatatctgga ggaggcccaa      540

ccccacccca gatgccaccg agccagccag gggcactcat cccaggagat ccgcaggcca      600

tgaaccagcc taacagaggt ccctcgcctt tcagtcctgt gcagctgcat cagcttcgag      660

ctcagatttt agcttacaaa atgttggcca ggggccagcc tctccctgaa actctgcagc      720

tggcagtcca gggaaaaagg accttgcctg gcatgcagca gcagcagcag caacaacaac      780

aacagcagca gcagcagcag cagcagcagc agcaacagca gcaacaacag cagccccagc      840

agcctcagca gcaggctcag gcacagcccc agcagcagca gcaacagcag cagcagccag      900

ctcttgttag ctataatcga ccatctggcc ccgggcagga gctgctactg agtggccaga      960

gcgctccgca gaagctgtca gcaccagcac caagcggccg accttcaccg gcaccccagg     1020

ccgccgtcca gcccacggcc acagcggtgc ccgggccctc cgtgcagcag cccgccccag     1080

ggcagccgtc tccggtccta cagctgcaac agaagcagag ccgcatcagc cccatccaga     1140

aaccgcaagg cctggacccg gtggagatcc tgcaggaacg agagtacaga cttcaagctc     1200

gcatcgctca taggatacaa gaactggaaa gtctgcctgg ttccttgcca ccagatttac     1260

gcaccaaagc aaccgtggaa ctgaaagcac ttcgcttact caacttccaa cgtcagctga     1320

gacaggaggt ggtggcctgc atgcggaggg acaccaccct ggagacggcc ctcaactcca     1380

aagcatataa gcggagcaag cgccagaccc tgcgtgaggc acgcatgaca gagaaactgg     1440

agaagcagca gaagatagaa caggagagga aacgccggca gaaacaccag gaatacctga     1500

acagtatttt gcaacatgca aaagatttta aggaatatca ccggtctgtg gccgggaaga     1560

tccagaagct ctccaaagca gtggcgactt ggcatgctaa cacagaaagg gagcagaaga     1620

aggagacgga gcggatcgag aaggagagaa tgcggaggct gatggccgaa gatgaagagg     1680

gctacaggaa gcttattgac caaaagaaag acagacgtct cgcctaccta ttgcagcaga     1740

ccgatgagta tgtcgccaat ctgaccaacc tggtgtggga gcacaagcag gcccaagcag     1800

ccaaagagaa gaagaagagg aggaggagga agaagaaggc tgaagagaat gcagagggag     1860

gggaacctgc cctgggacca gatggagagc caatagatga aagcagccag atgagtgacc     1920

tgcctgtcaa agtgacacac acagaaactg gcaaggtcct ctttggacca gaagcaccca     1980

aagcaagtca gctggatgcc tggctggaga tgaatcctgg ttacgaagtt gcacccagat     2040

ctgacagtga agagagtgaa tcggactacg aggaggagga tgaagaagaa gagtccagta     2100

ggcaggaaac cgaggagaag atactgctgg atcccaacag tgaagaagtt tccgaaaagg     2160

atgccaagca gatcattgag actgcgaagc aggacgtgga cgacgaatac agcatgcagt     2220

acagtgccag aggctctcag tcctactaca cggtggctca cgctatctct gagagggtgg     2280

agaagcagtc tgccctcctc attaacggca ccctaaagca ttaccagctc cagggcctgg     2340

aatggatggt ttccctgtat aataacaatc tgaacggaat cttagctgat gaaatggggc     2400

taggcaagac catccagacc attgcactca tcacgtatct gatggagcac aaaaggctca     2460

atggtcccta cctcatcatc gtccccctct cgactctgtc taactggaca tatgaatttg     2520

acaaatgggc tccttctgtg gtgaaaattt cttacaaggg tacccctgcc atgcgacgct     2580

ccctcgttcc ccagctacgg agtggcaaat tcaatgtcct cctgactact tacgagtaca     2640

ttataaaaga caagcacatt cttgcaaaga ttcggtggaa gtacatgatc gtggacgaag     2700

gccaccggat gaagaatcac cactgcaagc taacccaggt cctgaacaca cactatgtgg     2760

cccccaggcg gatccttctg actgggaccc cactgcagaa taagcttccg gaactctggg     2820

ccctcctcaa cttcctcctc cctacaatct tcaagagttg cagcacattt gagcagtggt     2880

ttaatgctcc atttgccatg accggtgaaa gggtggacct gaacgaagaa gaaacgattt     2940

tgatcatcag gcgtctacac aaggtgctga gacccttttt actgaggagg ctgaagaaag     3000

aggttgagtc tcagcttccg gaaaaggttg agtatgtgat caagtgtgac atgtcagctc     3060

tgcagaagat tctgtaccgt cacatgcaag ccaaggggat cctcctcacg gacgggtctg     3120

agaaagataa gaaggggaaa ggaggtgcca agacacttat gaacaccatc atgcagctga     3180

gaaaaatatg caaccaccca tatatgtttc agcacattga ggaatccttt gctgaacacc     3240

tgggctattc gaatggggtc atcaatgggg ctgagctgta tcgggcctcg ggaaagtttg     3300

agctgcttga tcgtattctg cccaaattga gagcgactaa ccaccgcgtg ctgcttttct     3360

gccagatgac gtcactcatg accattatgg aggattactt tgcttttcgg aacttcctgt     3420

acctgcgcct tgacggcacc accaagtctg aagatcgtgc tgctttgcta aagaaattca     3480

atgaacctgg gtcccagtat ttcattttct tgctgagcac aagagcaggg ggcctgggct     3540

taaatcttca ggcggcagac acggtggtca tatttgacag cgactggaat cctcaccagg     3600

atctgcaggc ccaagaccga gctcaccgca ttggccaaca aaacgaggtc cgggtgctga     3660

ggctttgcac cgtcaacagt gtggaggaaa agattctcgc ggctgccaag tacaagctga     3720

acgtggatca gaaggttatc caagcaggca tgtttgacca gaagtcatcc agccacgagc     3780

ggagggcctt cctgcaggcc attctggagc acgaggagga gaatgaggaa gaagatgagg     3840

taccagacga cgagaccctg aaccagatga ttgctcgccg ggaggaagaa tttgatcttt     3900

ttatgcgcat ggacatggac cggcggaggg aggatgcccg gaacccgaag cgcaaacccc     3960

gcttgatgga ggaagatgag ctgccctcct ggattatcaa ggatgacgcc gaagtggaaa     4020

ggctcacctg tgaagaagag gaggagaaga tatttgggag gggctctcgc cagcgccggg     4080

atgtggacta cagtgatgcc ctcaccgaga agcaatggct cagggccatc gaagacggca     4140

atttggaaga aatggaagag gaggtacggc ttaagaagag aaaaagacga agaaatgtgg     4200

ataaagaccc cgtgaaggaa gatgtggaaa aagcgaagaa aagaagaggc cgccctccgg     4260

ctgagaagtt gtcaccaaat cccccaaaac taacgaagca gatgaacgcc atcattgata     4320

ctgtgataaa ctacaaagac agttcagggc gacagctcag tgaagtcttc attcagttac     4380

cttccaggaa agacttacca gaatactatg aattaattag gaagccagtg gatttcaaaa     4440

agataaagga gcgaatccgt aatcataagt atcggagcct gggagacctg gagaaagacg     4500

tcatgcttct ctgtcacaac gcacagacat tcaacttgga aggatcccag atctacgaag     4560

actccattgt cctacagtca gtgtttaaga gtgctcggca gaaaattgcc aaagaagaag     4620

agagtgagga agaaagcaat gaagaagagg aagaagatga tgaagaggag tcggagtcag     4680

aggcgaaatc tgtgaaggtg aaaatcaagc tgaataaaaa ggaagagaaa ggccgggaca     4740

cagggaaggg caagaagcgg ccaaaccgag gcaaagccaa acccgtcgtg agcgattttg     4800

acagtgacga ggaacaggaa gagaacgaac agtcagaagc aagtggaact gataacgagt     4860

gaccatcctg gacgtgagct tcccgcggtg gcagaaccga atgctttctt ccccctctcc     4920

ttcctcccca gtgagttcac ttgccattcg ggcacactgg gttatttctc cgtcctcatt     4980

gtcatctaga actagcttta gggtagtgcc agacaaacat atgatatcat ggtgtaaaaa     5040

aagaaacaca tgcgtgcaga cacactacac acacacacac acacacacac acacacacac     5100

acacatattt gtaacatatt gtgaccaaat gggcctcaaa gattcaaaga ttaaaaacaa     5160

aaagcttttg atggaaaaga tgtgggtgga tagtatattt ctacaggtgg gtcaggtttg     5220

gtagcagttt gatgtgctgg gttctgtcat ctgttctgat gagaagattt ttatcttctg     5280

cagtgctgat ggccgggagg aaccattcaa agccactggt tattttgttt ttcatcaggc     5340

gattttcaag attttcattt gtttcagtat tgttggtttt ctcttttctc ttttttacac     5400

tgtggtacat ataagcaact tgactagtga caaatgtaca gtagttagat atcacctaca     5460

tatacatttt tccattttat gctctatgat ctgaagaaca aaaaaaaaag ctttttgact     5520

tgtataagat ttatgtctac tgtaaacatt gcggaatttt tttttgttct tgttttattg     5580

acaatgctat tgagtattac agtgtctaga ataccctgga tggcttctct tgtccacccg     5640

atctcccgtg ttaccaatgt gtatggtctc cttctcccga aagtgtactt aatctttgct     5700

ttctttgcac aatgtctttg gttgcaagtc ataagcctga ggcaaataaa attccagtaa     5760

tttccaagaa tgtggtgttg gtactttcct aataaaccga taacgtacct tgaaaaaaaa     5820

aaaaaaaaaa a                                                          5831


<210> 186
<211> 1583
<212> PRT
<213> Mus musculus

<400> 186
Met Ser Thr Pro Thr Asp Pro Ala Ala Met Pro His Pro Gly Pro Ser 
1               5                   10                  15      


Pro Gly Pro Gly Pro Ser Pro Gly Pro Ile Leu Gly Pro Ser Pro Gly 
            20                  25                  30          


Pro Gly Pro Ser Pro Gly Ser Val His Ser Met Met Gly Pro Ser Pro 
        35                  40                  45              


Gly Pro Pro Ser Val Ser His Pro Leu Ser Thr Met Gly Ser Ala Asp 
    50                  55                  60                  


Phe Pro Gln Glu Gly Met His Gln Leu His Lys Pro Met Asp Gly Ile 
65                  70                  75                  80  


His Asp Lys Gly Ile Val Glu Asp Val His Cys Gly Ser Met Lys Gly 
                85                  90                  95      


Thr Ser Met Arg Pro Pro His Pro Gly Met Gly Pro Pro Gln Ser Pro 
            100                 105                 110         


Met Asp Gln His Ser Gln Gly Tyr Met Ser Pro His Pro Ser Pro Leu 
        115                 120                 125             


Gly Ala Pro Glu His Val Ser Ser Pro Ile Ser Gly Gly Gly Pro Thr 
    130                 135                 140                 


Pro Pro Gln Met Pro Pro Ser Gln Pro Gly Ala Leu Ile Pro Gly Asp 
145                 150                 155                 160 


Pro Gln Ala Met Asn Gln Pro Asn Arg Gly Pro Ser Pro Phe Ser Pro 
                165                 170                 175     


Val Gln Leu His Gln Leu Arg Ala Gln Ile Leu Ala Tyr Lys Met Leu 
            180                 185                 190         


Ala Arg Gly Gln Pro Leu Pro Glu Thr Leu Gln Leu Ala Val Gln Gly 
        195                 200                 205             


Lys Arg Thr Leu Pro Gly Met Gln Gln Gln Gln Gln Gln Gln Gln Gln 
    210                 215                 220                 


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
225                 230                 235                 240 


Gln Pro Gln Gln Pro Gln Gln Gln Ala Gln Ala Gln Pro Gln Gln Gln 
                245                 250                 255     


Gln Gln Gln Gln Gln Gln Pro Ala Leu Val Ser Tyr Asn Arg Pro Ser 
            260                 265                 270         


Gly Pro Gly Gln Glu Leu Leu Leu Ser Gly Gln Ser Ala Pro Gln Lys 
        275                 280                 285             


Leu Ser Ala Pro Ala Pro Ser Gly Arg Pro Ser Pro Ala Pro Gln Ala 
    290                 295                 300                 


Ala Val Gln Pro Thr Ala Thr Ala Val Pro Gly Pro Ser Val Gln Gln 
305                 310                 315                 320 


Pro Ala Pro Gly Gln Pro Ser Pro Val Leu Gln Leu Gln Gln Lys Gln 
                325                 330                 335     


Ser Arg Ile Ser Pro Ile Gln Lys Pro Gln Gly Leu Asp Pro Val Glu 
            340                 345                 350         


Ile Leu Gln Glu Arg Glu Tyr Arg Leu Gln Ala Arg Ile Ala His Arg 
        355                 360                 365             


Ile Gln Glu Leu Glu Ser Leu Pro Gly Ser Leu Pro Pro Asp Leu Arg 
    370                 375                 380                 


Thr Lys Ala Thr Val Glu Leu Lys Ala Leu Arg Leu Leu Asn Phe Gln 
385                 390                 395                 400 


Arg Gln Leu Arg Gln Glu Val Val Ala Cys Met Arg Arg Asp Thr Thr 
                405                 410                 415     


Leu Glu Thr Ala Leu Asn Ser Lys Ala Tyr Lys Arg Ser Lys Arg Gln 
            420                 425                 430         


Thr Leu Arg Glu Ala Arg Met Thr Glu Lys Leu Glu Lys Gln Gln Lys 
        435                 440                 445             


Ile Glu Gln Glu Arg Lys Arg Arg Gln Lys His Gln Glu Tyr Leu Asn 
    450                 455                 460                 


Ser Ile Leu Gln His Ala Lys Asp Phe Lys Glu Tyr His Arg Ser Val 
465                 470                 475                 480 


Ala Gly Lys Ile Gln Lys Leu Ser Lys Ala Val Ala Thr Trp His Ala 
                485                 490                 495     


Asn Thr Glu Arg Glu Gln Lys Lys Glu Thr Glu Arg Ile Glu Lys Glu 
            500                 505                 510         


Arg Met Arg Arg Leu Met Ala Glu Asp Glu Glu Gly Tyr Arg Lys Leu 
        515                 520                 525             


Ile Asp Gln Lys Lys Asp Arg Arg Leu Ala Tyr Leu Leu Gln Gln Thr 
    530                 535                 540                 


Asp Glu Tyr Val Ala Asn Leu Thr Asn Leu Val Trp Glu His Lys Gln 
545                 550                 555                 560 


Ala Gln Ala Ala Lys Glu Lys Lys Lys Arg Arg Arg Arg Lys Lys Lys 
                565                 570                 575     


Ala Glu Glu Asn Ala Glu Gly Gly Glu Pro Ala Leu Gly Pro Asp Gly 
            580                 585                 590         


Glu Pro Ile Asp Glu Ser Ser Gln Met Ser Asp Leu Pro Val Lys Val 
        595                 600                 605             


Thr His Thr Glu Thr Gly Lys Val Leu Phe Gly Pro Glu Ala Pro Lys 
    610                 615                 620                 


Ala Ser Gln Leu Asp Ala Trp Leu Glu Met Asn Pro Gly Tyr Glu Val 
625                 630                 635                 640 


Ala Pro Arg Ser Asp Ser Glu Glu Ser Glu Ser Asp Tyr Glu Glu Glu 
                645                 650                 655     


Asp Glu Glu Glu Glu Ser Ser Arg Gln Glu Thr Glu Glu Lys Ile Leu 
            660                 665                 670         


Leu Asp Pro Asn Ser Glu Glu Val Ser Glu Lys Asp Ala Lys Gln Ile 
        675                 680                 685             


Ile Glu Thr Ala Lys Gln Asp Val Asp Asp Glu Tyr Ser Met Gln Tyr 
    690                 695                 700                 


Ser Ala Arg Gly Ser Gln Ser Tyr Tyr Thr Val Ala His Ala Ile Ser 
705                 710                 715                 720 


Glu Arg Val Glu Lys Gln Ser Ala Leu Leu Ile Asn Gly Thr Leu Lys 
                725                 730                 735     


His Tyr Gln Leu Gln Gly Leu Glu Trp Met Val Ser Leu Tyr Asn Asn 
            740                 745                 750         


Asn Leu Asn Gly Ile Leu Ala Asp Glu Met Gly Leu Gly Lys Thr Ile 
        755                 760                 765             


Gln Thr Ile Ala Leu Ile Thr Tyr Leu Met Glu His Lys Arg Leu Asn 
    770                 775                 780                 


Gly Pro Tyr Leu Ile Ile Val Pro Leu Ser Thr Leu Ser Asn Trp Thr 
785                 790                 795                 800 


Tyr Glu Phe Asp Lys Trp Ala Pro Ser Val Val Lys Ile Ser Tyr Lys 
                805                 810                 815     


Gly Thr Pro Ala Met Arg Arg Ser Leu Val Pro Gln Leu Arg Ser Gly 
            820                 825                 830         


Lys Phe Asn Val Leu Leu Thr Thr Tyr Glu Tyr Ile Ile Lys Asp Lys 
        835                 840                 845             


His Ile Leu Ala Lys Ile Arg Trp Lys Tyr Met Ile Val Asp Glu Gly 
    850                 855                 860                 


His Arg Met Lys Asn His His Cys Lys Leu Thr Gln Val Leu Asn Thr 
865                 870                 875                 880 


His Tyr Val Ala Pro Arg Arg Ile Leu Leu Thr Gly Thr Pro Leu Gln 
                885                 890                 895     


Asn Lys Leu Pro Glu Leu Trp Ala Leu Leu Asn Phe Leu Leu Pro Thr 
            900                 905                 910         


Ile Phe Lys Ser Cys Ser Thr Phe Glu Gln Trp Phe Asn Ala Pro Phe 
        915                 920                 925             


Ala Met Thr Gly Glu Arg Val Asp Leu Asn Glu Glu Glu Thr Ile Leu 
    930                 935                 940                 


Ile Ile Arg Arg Leu His Lys Val Leu Arg Pro Phe Leu Leu Arg Arg 
945                 950                 955                 960 


Leu Lys Lys Glu Val Glu Ser Gln Leu Pro Glu Lys Val Glu Tyr Val 
                965                 970                 975     


Ile Lys Cys Asp Met Ser Ala Leu Gln Lys Ile Leu Tyr Arg His Met 
            980                 985                 990         


Gln Ala Lys Gly Ile Leu Leu Thr  Asp Gly Ser Glu Lys  Asp Lys Lys 
        995                 1000                 1005             


Gly Lys  Gly Gly Ala Lys Thr  Leu Met Asn Thr Ile  Met Gln Leu 
    1010                 1015                 1020             


Arg Lys  Ile Cys Asn His Pro  Tyr Met Phe Gln His  Ile Glu Glu 
    1025                 1030                 1035             


Ser Phe  Ala Glu His Leu Gly  Tyr Ser Asn Gly Val  Ile Asn Gly 
    1040                 1045                 1050             


Ala Glu  Leu Tyr Arg Ala Ser  Gly Lys Phe Glu Leu  Leu Asp Arg 
    1055                 1060                 1065             


Ile Leu  Pro Lys Leu Arg Ala  Thr Asn His Arg Val  Leu Leu Phe 
    1070                 1075                 1080             


Cys Gln  Met Thr Ser Leu Met  Thr Ile Met Glu Asp  Tyr Phe Ala 
    1085                 1090                 1095             


Phe Arg  Asn Phe Leu Tyr Leu  Arg Leu Asp Gly Thr  Thr Lys Ser 
    1100                 1105                 1110             


Glu Asp  Arg Ala Ala Leu Leu  Lys Lys Phe Asn Glu  Pro Gly Ser 
    1115                 1120                 1125             


Gln Tyr  Phe Ile Phe Leu Leu  Ser Thr Arg Ala Gly  Gly Leu Gly 
    1130                 1135                 1140             


Leu Asn  Leu Gln Ala Ala Asp  Thr Val Val Ile Phe  Asp Ser Asp 
    1145                 1150                 1155             


Trp Asn  Pro His Gln Asp Leu  Gln Ala Gln Asp Arg  Ala His Arg 
    1160                 1165                 1170             


Ile Gly  Gln Gln Asn Glu Val  Arg Val Leu Arg Leu  Cys Thr Val 
    1175                 1180                 1185             


Asn Ser  Val Glu Glu Lys Ile  Leu Ala Ala Ala Lys  Tyr Lys Leu 
    1190                 1195                 1200             


Asn Val  Asp Gln Lys Val Ile  Gln Ala Gly Met Phe  Asp Gln Lys 
    1205                 1210                 1215             


Ser Ser  Ser His Glu Arg Arg  Ala Phe Leu Gln Ala  Ile Leu Glu 
    1220                 1225                 1230             


His Glu  Glu Glu Asn Glu Glu  Glu Asp Glu Val Pro  Asp Asp Glu 
    1235                 1240                 1245             


Thr Leu  Asn Gln Met Ile Ala  Arg Arg Glu Glu Glu  Phe Asp Leu 
    1250                 1255                 1260             


Phe Met  Arg Met Asp Met Asp  Arg Arg Arg Glu Asp  Ala Arg Asn 
    1265                 1270                 1275             


Pro Lys  Arg Lys Pro Arg Leu  Met Glu Glu Asp Glu  Leu Pro Ser 
    1280                 1285                 1290             


Trp Ile  Ile Lys Asp Asp Ala  Glu Val Glu Arg Leu  Thr Cys Glu 
    1295                 1300                 1305             


Glu Glu  Glu Glu Lys Ile Phe  Gly Arg Gly Ser Arg  Gln Arg Arg 
    1310                 1315                 1320             


Asp Val  Asp Tyr Ser Asp Ala  Leu Thr Glu Lys Gln  Trp Leu Arg 
    1325                 1330                 1335             


Ala Ile  Glu Asp Gly Asn Leu  Glu Glu Met Glu Glu  Glu Val Arg 
    1340                 1345                 1350             


Leu Lys  Lys Arg Lys Arg Arg  Arg Asn Val Asp Lys  Asp Pro Val 
    1355                 1360                 1365             


Lys Glu  Asp Val Glu Lys Ala  Lys Lys Arg Arg Gly  Arg Pro Pro 
    1370                 1375                 1380             


Ala Glu  Lys Leu Ser Pro Asn  Pro Pro Lys Leu Thr  Lys Gln Met 
    1385                 1390                 1395             


Asn Ala  Ile Ile Asp Thr Val  Ile Asn Tyr Lys Asp  Ser Ser Gly 
    1400                 1405                 1410             


Arg Gln  Leu Ser Glu Val Phe  Ile Gln Leu Pro Ser  Arg Lys Asp 
    1415                 1420                 1425             


Leu Pro  Glu Tyr Tyr Glu Leu  Ile Arg Lys Pro Val  Asp Phe Lys 
    1430                 1435                 1440             


Lys Ile  Lys Glu Arg Ile Arg  Asn His Lys Tyr Arg  Ser Leu Gly 
    1445                 1450                 1455             


Asp Leu  Glu Lys Asp Val Met  Leu Leu Cys His Asn  Ala Gln Thr 
    1460                 1465                 1470             


Phe Asn  Leu Glu Gly Ser Gln  Ile Tyr Glu Asp Ser  Ile Val Leu 
    1475                 1480                 1485             


Gln Ser  Val Phe Lys Ser Ala  Arg Gln Lys Ile Ala  Lys Glu Glu 
    1490                 1495                 1500             


Glu Ser  Glu Glu Glu Ser Asn  Glu Glu Glu Glu Glu  Asp Asp Glu 
    1505                 1510                 1515             


Glu Glu  Ser Glu Ser Glu Ala  Lys Ser Val Lys Val  Lys Ile Lys 
    1520                 1525                 1530             


Leu Asn  Lys Lys Glu Glu Lys  Gly Arg Asp Thr Gly  Lys Gly Lys 
    1535                 1540                 1545             


Lys Arg  Pro Asn Arg Gly Lys  Ala Lys Pro Val Val  Ser Asp Phe 
    1550                 1555                 1560             


Asp Ser  Asp Glu Glu Gln Glu  Glu Asn Glu Gln Ser  Glu Ala Ser 
    1565                 1570                 1575             


Gly Thr  Asp Asn Glu 
    1580             


<210> 187
<211> 1964
<212> DNA
<213> Mus musculus

<400> 187
ttcacttcat taaatctaga ggcggttcag catgggagcc gtctgtatgt tgaattaggg       60

ctcgctctct tgcgcaacac gtcaccagtc ggaaactggg ggtttgcttc tgtgatttat      120

ttcattattg tgctggtaaa agctgatgaa gagactagca gctcgctgct ttgccggctt      180

gttaatttta tccccactaa ctgtgatttc cgatagccgg cctgctgata gtggtaagtg      240

cggctggctc tggtttaaag caagcgtttg caggccatcg aagacggcaa tttggaagaa      300

atggaagagg aggtacggct taagaagaga aaaagacgaa gaaatgtgga taaagacccc      360

gtgaaggaag atgtggaaaa agcgaagaaa agaagaggcc gccctccggc tgagaagttg      420

tcaccaaatc ccccaaaact aacgaagcag atgaacgcca tcattgatac tgtgataaac      480

tacaaagaca gttcagggcg acagctcagt gaagtcttca ttcagttacc ttccaggaaa      540

gacttaccag aatactatga attaattagg aagccagtgg atttcaaaaa gataaaggag      600

cgaatccgta atcataagta tcggagcctg ggagacctgg agaaagacgt catgcttctc      660

tgtcacaacg cacagacatt caacttggaa ggatcccaga tctacgaaga ctccattgtc      720

ctacagtcag tgtttaagag tgctcggcag aaaattgcca aagaagaaga gagtgaggaa      780

gaaagcaatg aagaagagga agaagatgat gaagaggagt cggagtcaga ggcgaaatct      840

gtgaaggtga aaatcaagct gaataaaaag gaagagaaag gccgggacac agggaagggc      900

aagaagcggc caaaccgagg caaagccaaa cccgtcgtga gcgattttga cagtgacgag      960

gaacaggaag agaacgaaca gtcagaagca agtggaactg ataacgagtg accatcctgg     1020

acgtgagctt cccgcggtgg cagaaccgaa tgctttcttc cccctctcct tcctccccag     1080

tgagttcact tgccattcgg gcacactggg ttatttctcc gtcctcattg tcatctagaa     1140

ctagctttag ggtagtgcca gacaaacata tgatatcatg gtgtaaaaaa agaaacacat     1200

gcgtgcagac acactacaca cacacacaca cacacacaca cacacacaca cacatatttg     1260

taacatattg tgaccaaatg ggcctcaaag attcaaagat taaaaacaaa aagcttttga     1320

tggaaaagat gtgggtggat agtatatttc tacaggtggg tcaggtttgg tagcagtttg     1380

atgtgctggg ttctgtcatc tgttctgatg agaagatttt tatcttctgc agtgctgatg     1440

gccgggagga accattcaaa gccactggtt attttgtttt tcatcaggcg attttcaaga     1500

ttttcatttg tttcagtatt gttggttttc tcttttctct tttttacact gtggtacata     1560

taagcaactt gactagtgac aaatgtacag tagttagata tcacctacat atacattttt     1620

ccattttatg ctctatgatc tgaagaacaa aaaaaaaagc tttttgactt gtataagatt     1680

tatgtctact gtaaacattg cggaattttt ttttgttctt gttttattga caatgctatt     1740

gagtattaca gtgtctagaa taccctggat ggcttctctt gtccacccga tctcccgtgt     1800

taccaatgtg tatggtctcc ttctcccgaa agtgtactta atctttgctt tctttgcaca     1860

atgtctttgg ttgcaagtca taagcctgag gcaaataaaa ttccagtaat ttccaagaat     1920

gtggtgttgg tactttccta ataaaccgat aacgtacctt gaaa                      1964


<210> 188
<211> 236
<212> PRT
<213> Mus musculus

<400> 188
Met Glu Glu Glu Val Arg Leu Lys Lys Arg Lys Arg Arg Arg Asn Val 
1               5                   10                  15      


Asp Lys Asp Pro Val Lys Glu Asp Val Glu Lys Ala Lys Lys Arg Arg 
            20                  25                  30          


Gly Arg Pro Pro Ala Glu Lys Leu Ser Pro Asn Pro Pro Lys Leu Thr 
        35                  40                  45              


Lys Gln Met Asn Ala Ile Ile Asp Thr Val Ile Asn Tyr Lys Asp Ser 
    50                  55                  60                  


Ser Gly Arg Gln Leu Ser Glu Val Phe Ile Gln Leu Pro Ser Arg Lys 
65                  70                  75                  80  


Asp Leu Pro Glu Tyr Tyr Glu Leu Ile Arg Lys Pro Val Asp Phe Lys 
                85                  90                  95      


Lys Ile Lys Glu Arg Ile Arg Asn His Lys Tyr Arg Ser Leu Gly Asp 
            100                 105                 110         


Leu Glu Lys Asp Val Met Leu Leu Cys His Asn Ala Gln Thr Phe Asn 
        115                 120                 125             


Leu Glu Gly Ser Gln Ile Tyr Glu Asp Ser Ile Val Leu Gln Ser Val 
    130                 135                 140                 


Phe Lys Ser Ala Arg Gln Lys Ile Ala Lys Glu Glu Glu Ser Glu Glu 
145                 150                 155                 160 


Glu Ser Asn Glu Glu Glu Glu Glu Asp Asp Glu Glu Glu Ser Glu Ser 
                165                 170                 175     


Glu Ala Lys Ser Val Lys Val Lys Ile Lys Leu Asn Lys Lys Glu Glu 
            180                 185                 190         


Lys Gly Arg Asp Thr Gly Lys Gly Lys Lys Arg Pro Asn Arg Gly Lys 
        195                 200                 205             


Ala Lys Pro Val Val Ser Asp Phe Asp Ser Asp Glu Glu Gln Glu Glu 
    210                 215                 220                 


Asn Glu Gln Ser Glu Ala Ser Gly Thr Asp Asn Glu 
225                 230                 235     


<210> 189
<211> 1979
<212> DNA
<213> Mus musculus

<400> 189
acacacacac acacacacac acgcaggctg aagtatgctt aactctttta acttggctgg       60

ggctttttag caccatatgg gttctttcgt gacgtccgga cccgaaagag tgcagtgtgc      120

ctttaaggaa agaggtacct caccaaactt ccctgtagtt gtgcctcacc atttagctga      180

tgaagagact agcagctcgc tgctttgccg gcttgttaat tttatcccca ctaactgtga      240

tttccgatag ccggcctgct gatagtggta aggccatcga agacggcaat ttggaagaaa      300

tggaagagga ggtacggctt aagaagagaa aaagacgaag aaatgtggat aaagaccccg      360

tgaaggaaga tgtggaaaaa gcgaagaaaa gaagaggccg ccctccggct gagaagttgt      420

caccaaatcc cccaaaacta acgaagcaga tgaacgccat cattgatact gtgataaact      480

acaaagacag ttcagggcga cagctcagtg aagtcttcat tcagttacct tccaggaaag      540

acttaccaga atactatgaa ttaattagga agccagtgga tttcaaaaag ataaaggagc      600

gaatccgtaa tcataagtat cggagcctgg gagacctgga gaaagacgtc atgcttctct      660

gtcacaacgc acagacattc aacttggaag gatcccagat ctacgaagac tccattgtcc      720

tacagtcagt gtttaagagt gctcggcaga aaattgccaa agaagaagag agtgaggaag      780

aaagcaatga agaagaggaa gaagatgatg aagaggagtc ggagtcagag gcgaaatctg      840

tgaaggtgaa aatcaagctg aataaaaagg aagagaaagg ccgggacaca gggaagggca      900

agaagcggcc aaaccgaggc aaagccaaac ccgtcgtgag cgattttgac agtgacgagg      960

aacaggaaga gaacgaacag tcagaagcaa gtggaactga taacgagtga ccatcctgga     1020

cgtgagcttc ccgcggtggc agaaccgaat gctttcttcc ccctctcctt cctccccagt     1080

gagttcactt gccattcggg cacactgggt tatttctccg tcctcattgt catctagaac     1140

tagctttagg gtagtgccag acaaacatat gatatcatgg tgtaaaaaaa gaaacacatg     1200

cgtgcagaca cactacacac acacacacac acacacacac acacacacac acatatttgt     1260

aacatattgt gaccaaatgg gcctcaaaga ttcaaagatt aaaaacaaaa agcttttgat     1320

ggaaaagatg tgggtggata gtatatttct acaggtgggt caggtttggt agcagtttga     1380

tgtgctgggt tctgtcatct gttctgatga gaagattttt atcttctgca gtgctgatgg     1440

ccgggaggaa ccattcaaag ccactggtta ttttgttttt catcaggcga ttttcaagat     1500

tttcatttgt ttcagtattg ttggttttct cttttctctt ttttacactg tggtacatat     1560

aagcaacttg actagtgaca aatgtacagt agttagatat cacctacata tacatttttc     1620

cattttatgc tctatgatct gaagaacaaa aaaaaaagct ttttgacttg tataagattt     1680

atgtctactg taaacattgc ggaatttttt tttgttcttg ttttattgac aatgctattg     1740

agtattacag tgtctagaat accctggatg gcttctcttg tccacccgat ctcccgtgtt     1800

accaatgtgt atggtctcct tctcccgaaa gtgtacttaa tctttgcttt ctttgcacaa     1860

tgtctttggt tgcaagtcat aagcctgagg caaataaaat tccagtaatt tccaagaatg     1920

tggtgttggt actttcctaa taaaccgata acgtaccttg aaaaaaaaaa aaaaaaaaa      1979


<210> 190
<211> 276
<212> PRT
<213> Mus musculus

<400> 190
Met Lys Arg Leu Ala Ala Arg Cys Phe Ala Gly Leu Leu Ile Leu Ser 
1               5                   10                  15      


Pro Leu Thr Val Ile Ser Asp Ser Arg Pro Ala Asp Ser Gly Lys Ala 
            20                  25                  30          


Ile Glu Asp Gly Asn Leu Glu Glu Met Glu Glu Glu Val Arg Leu Lys 
        35                  40                  45              


Lys Arg Lys Arg Arg Arg Asn Val Asp Lys Asp Pro Val Lys Glu Asp 
    50                  55                  60                  


Val Glu Lys Ala Lys Lys Arg Arg Gly Arg Pro Pro Ala Glu Lys Leu 
65                  70                  75                  80  


Ser Pro Asn Pro Pro Lys Leu Thr Lys Gln Met Asn Ala Ile Ile Asp 
                85                  90                  95      


Thr Val Ile Asn Tyr Lys Asp Ser Ser Gly Arg Gln Leu Ser Glu Val 
            100                 105                 110         


Phe Ile Gln Leu Pro Ser Arg Lys Asp Leu Pro Glu Tyr Tyr Glu Leu 
        115                 120                 125             


Ile Arg Lys Pro Val Asp Phe Lys Lys Ile Lys Glu Arg Ile Arg Asn 
    130                 135                 140                 


His Lys Tyr Arg Ser Leu Gly Asp Leu Glu Lys Asp Val Met Leu Leu 
145                 150                 155                 160 


Cys His Asn Ala Gln Thr Phe Asn Leu Glu Gly Ser Gln Ile Tyr Glu 
                165                 170                 175     


Asp Ser Ile Val Leu Gln Ser Val Phe Lys Ser Ala Arg Gln Lys Ile 
            180                 185                 190         


Ala Lys Glu Glu Glu Ser Glu Glu Glu Ser Asn Glu Glu Glu Glu Glu 
        195                 200                 205             


Asp Asp Glu Glu Glu Ser Glu Ser Glu Ala Lys Ser Val Lys Val Lys 
    210                 215                 220                 


Ile Lys Leu Asn Lys Lys Glu Glu Lys Gly Arg Asp Thr Gly Lys Gly 
225                 230                 235                 240 


Lys Lys Arg Pro Asn Arg Gly Lys Ala Lys Pro Val Val Ser Asp Phe 
                245                 250                 255     


Asp Ser Asp Glu Glu Gln Glu Glu Asn Glu Gln Ser Glu Ala Ser Gly 
            260                 265                 270         


Thr Asp Asn Glu 
        275     


<210> 191
<211> 1679
<212> PRT
<213> Homo sapiens

<400> 191
Met Ser Thr Pro Asp Pro Pro Leu Gly Gly Thr Pro Arg Pro Gly Pro 
1               5                   10                  15      


Ser Pro Gly Pro Gly Pro Ser Pro Gly Ala Met Leu Gly Pro Ser Pro 
            20                  25                  30          


Gly Pro Ser Pro Gly Ser Ala His Ser Met Met Gly Pro Ser Pro Gly 
        35                  40                  45              


Pro Pro Ser Ala Gly His Pro Ile Pro Thr Gln Gly Pro Gly Gly Tyr 
    50                  55                  60                  


Pro Gln Asp Asn Met His Gln Met His Lys Pro Met Glu Ser Met His 
65                  70                  75                  80  


Glu Lys Gly Met Ser Asp Asp Pro Arg Tyr Asn Gln Met Lys Gly Met 
                85                  90                  95      


Gly Met Arg Ser Gly Gly His Ala Gly Met Gly Pro Pro Pro Ser Pro 
            100                 105                 110         


Met Asp Gln His Ser Gln Gly Tyr Pro Ser Pro Leu Gly Gly Ser Glu 
        115                 120                 125             


His Ala Ser Ser Pro Val Pro Ala Ser Gly Pro Ser Ser Gly Pro Gln 
    130                 135                 140                 


Met Ser Ser Gly Pro Gly Gly Ala Pro Leu Asp Gly Ala Asp Pro Gln 
145                 150                 155                 160 


Ala Leu Gly Gln Gln Asn Arg Gly Pro Thr Pro Phe Asn Gln Asn Gln 
                165                 170                 175     


Leu His Gln Leu Arg Ala Gln Ile Met Ala Tyr Lys Met Leu Ala Arg 
            180                 185                 190         


Gly Gln Pro Leu Pro Asp His Leu Gln Met Ala Val Gln Gly Lys Arg 
        195                 200                 205             


Pro Met Pro Gly Met Gln Gln Gln Met Pro Thr Leu Pro Pro Pro Ser 
    210                 215                 220                 


Val Ser Ala Thr Gly Pro Gly Pro Gly Pro Gly Pro Gly Pro Gly Pro 
225                 230                 235                 240 


Gly Pro Gly Pro Ala Pro Pro Asn Tyr Ser Arg Pro His Gly Met Gly 
                245                 250                 255     


Gly Pro Asn Met Pro Pro Pro Gly Pro Ser Gly Val Pro Pro Gly Met 
            260                 265                 270         


Pro Gly Gln Pro Pro Gly Gly Pro Pro Lys Pro Trp Pro Glu Gly Pro 
        275                 280                 285             


Met Ala Asn Ala Ala Ala Pro Thr Ser Thr Pro Gln Lys Leu Ile Pro 
    290                 295                 300                 


Pro Gln Pro Thr Gly Arg Pro Ser Pro Ala Pro Pro Ala Val Pro Pro 
305                 310                 315                 320 


Ala Ala Ser Pro Val Met Pro Pro Gln Thr Gln Ser Pro Gly Gln Pro 
                325                 330                 335     


Ala Gln Pro Ala Pro Met Val Pro Leu His Gln Lys Gln Ser Arg Ile 
            340                 345                 350         


Thr Pro Ile Gln Lys Pro Arg Gly Leu Asp Pro Val Glu Ile Leu Gln 
        355                 360                 365             


Glu Arg Glu Tyr Arg Leu Gln Ala Arg Ile Ala His Arg Ile Gln Glu 
    370                 375                 380                 


Leu Glu Asn Leu Pro Gly Ser Leu Ala Gly Asp Leu Arg Thr Lys Ala 
385                 390                 395                 400 


Thr Ile Glu Leu Lys Ala Leu Arg Leu Leu Asn Phe Gln Arg Gln Leu 
                405                 410                 415     


Arg Gln Glu Val Val Val Cys Met Arg Arg Asp Thr Ala Leu Glu Thr 
            420                 425                 430         


Ala Leu Asn Ala Lys Ala Tyr Lys Arg Ser Lys Arg Gln Ser Leu Arg 
        435                 440                 445             


Glu Ala Arg Ile Thr Glu Lys Leu Glu Lys Gln Gln Lys Ile Glu Gln 
    450                 455                 460                 


Glu Arg Lys Arg Arg Gln Lys His Gln Glu Tyr Leu Asn Ser Ile Leu 
465                 470                 475                 480 


Gln His Ala Lys Asp Phe Lys Glu Tyr His Arg Ser Val Thr Gly Lys 
                485                 490                 495     


Ile Gln Lys Leu Thr Lys Ala Val Ala Thr Tyr His Ala Asn Thr Glu 
            500                 505                 510         


Arg Glu Gln Lys Lys Glu Asn Glu Arg Ile Glu Lys Glu Arg Met Arg 
        515                 520                 525             


Arg Leu Met Ala Glu Asp Glu Glu Gly Tyr Arg Lys Leu Ile Asp Gln 
    530                 535                 540                 


Lys Lys Asp Lys Arg Leu Ala Tyr Leu Leu Gln Gln Thr Asp Glu Tyr 
545                 550                 555                 560 


Val Ala Asn Leu Thr Glu Leu Val Arg Gln His Lys Ala Ala Gln Val 
                565                 570                 575     


Ala Lys Glu Lys Lys Lys Lys Lys Lys Lys Lys Lys Ala Glu Asn Ala 
            580                 585                 590         


Glu Gly Gln Thr Pro Ala Ile Gly Pro Asp Gly Glu Pro Leu Asp Glu 
        595                 600                 605             


Thr Ser Gln Met Ser Asp Leu Pro Val Lys Val Ile His Val Glu Ser 
    610                 615                 620                 


Gly Lys Ile Leu Thr Gly Thr Asp Ala Pro Lys Ala Gly Gln Leu Glu 
625                 630                 635                 640 


Ala Trp Leu Glu Met Asn Pro Gly Tyr Glu Val Ala Pro Arg Ser Asp 
                645                 650                 655     


Ser Glu Glu Ser Gly Ser Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu 
            660                 665                 670         


Gln Pro Gln Ala Ala Gln Pro Pro Thr Leu Pro Val Glu Glu Lys Lys 
        675                 680                 685             


Lys Ile Pro Asp Pro Asp Ser Asp Asp Val Ser Glu Val Asp Ala Arg 
    690                 695                 700                 


His Ile Ile Glu Asn Ala Lys Gln Asp Val Asp Asp Glu Tyr Gly Val 
705                 710                 715                 720 


Ser Gln Ala Leu Ala Arg Gly Leu Gln Ser Tyr Tyr Ala Val Ala His 
                725                 730                 735     


Ala Val Thr Glu Arg Val Asp Lys Gln Ser Ala Leu Met Val Asn Gly 
            740                 745                 750         


Val Leu Lys Gln Tyr Gln Ile Lys Gly Leu Glu Trp Leu Val Ser Leu 
        755                 760                 765             


Tyr Asn Asn Asn Leu Asn Gly Ile Leu Ala Asp Glu Met Gly Leu Gly 
    770                 775                 780                 


Lys Thr Ile Gln Thr Ile Ala Leu Ile Thr Tyr Leu Met Glu His Lys 
785                 790                 795                 800 


Arg Ile Asn Gly Pro Phe Leu Ile Ile Val Pro Leu Ser Thr Leu Ser 
                805                 810                 815     


Asn Trp Ala Tyr Glu Phe Asp Lys Trp Ala Pro Ser Val Val Lys Val 
            820                 825                 830         


Ser Tyr Lys Gly Ser Pro Ala Ala Arg Arg Ala Phe Val Pro Gln Leu 
        835                 840                 845             


Arg Ser Gly Lys Phe Asn Val Leu Leu Thr Thr Tyr Glu Tyr Ile Ile 
    850                 855                 860                 


Lys Asp Lys His Ile Leu Ala Lys Ile Arg Trp Lys Tyr Met Ile Val 
865                 870                 875                 880 


Asp Glu Gly His Arg Met Lys Asn His His Cys Lys Leu Thr Gln Val 
                885                 890                 895     


Leu Asn Thr His Tyr Val Ala Pro Arg Arg Leu Leu Leu Thr Gly Thr 
            900                 905                 910         


Pro Leu Gln Asn Lys Leu Pro Glu Leu Trp Ala Leu Leu Asn Phe Leu 
        915                 920                 925             


Leu Pro Thr Ile Phe Lys Ser Cys Ser Thr Phe Glu Gln Trp Phe Asn 
    930                 935                 940                 


Ala Pro Phe Ala Met Thr Gly Glu Lys Val Asp Leu Asn Glu Glu Glu 
945                 950                 955                 960 


Thr Ile Leu Ile Ile Arg Arg Leu His Lys Val Leu Arg Pro Phe Leu 
                965                 970                 975     


Leu Arg Arg Leu Lys Lys Glu Val Glu Ala Gln Leu Pro Glu Lys Val 
            980                 985                 990         


Glu Tyr Val Ile Lys Cys Asp Met  Ser Ala Leu Gln Arg  Val Leu Tyr 
        995                 1000                 1005             


Arg His  Met Gln Ala Lys Gly  Val Leu Leu Thr Asp  Gly Ser Glu 
    1010                 1015                 1020             


Lys Asp  Lys Lys Gly Lys Gly  Gly Thr Lys Thr Leu  Met Asn Thr 
    1025                 1030                 1035             


Ile Met  Gln Leu Arg Lys Ile  Cys Asn His Pro Tyr  Met Phe Gln 
    1040                 1045                 1050             


His Ile  Glu Glu Ser Phe Ser  Glu His Leu Gly Phe  Thr Gly Gly 
    1055                 1060                 1065             


Ile Val  Gln Gly Leu Asp Leu  Tyr Arg Ala Ser Gly  Lys Phe Glu 
    1070                 1075                 1080             


Leu Leu  Asp Arg Ile Leu Pro  Lys Leu Arg Ala Thr  Asn His Lys 
    1085                 1090                 1095             


Val Leu  Leu Phe Cys Gln Met  Thr Ser Leu Met Thr  Ile Met Glu 
    1100                 1105                 1110             


Asp Tyr  Phe Ala Tyr Arg Gly  Phe Lys Tyr Leu Arg  Leu Asp Gly 
    1115                 1120                 1125             


Thr Thr  Lys Ala Glu Asp Arg  Gly Met Leu Leu Lys  Thr Phe Asn 
    1130                 1135                 1140             


Glu Pro  Gly Ser Glu Tyr Phe  Ile Phe Leu Leu Ser  Thr Arg Ala 
    1145                 1150                 1155             


Gly Gly  Leu Gly Leu Asn Leu  Gln Ser Ala Asp Thr  Val Ile Ile 
    1160                 1165                 1170             


Phe Asp  Ser Asp Trp Asn Pro  His Gln Asp Leu Gln  Ala Gln Asp 
    1175                 1180                 1185             


Arg Ala  His Arg Ile Gly Gln  Gln Asn Glu Val Arg  Val Leu Arg 
    1190                 1195                 1200             


Leu Cys  Thr Val Asn Ser Val  Glu Glu Lys Ile Leu  Ala Ala Ala 
    1205                 1210                 1215             


Lys Tyr  Lys Leu Asn Val Asp  Gln Lys Val Ile Gln  Ala Gly Met 
    1220                 1225                 1230             


Phe Asp  Gln Lys Ser Ser Ser  His Glu Arg Arg Ala  Phe Leu Gln 
    1235                 1240                 1245             


Ala Ile  Leu Glu His Glu Glu  Gln Asp Glu Ser Arg  His Cys Ser 
    1250                 1255                 1260             


Thr Gly  Ser Gly Ser Ala Ser  Phe Ala His Thr Ala  Pro Pro Pro 
    1265                 1270                 1275             


Ala Gly  Val Asn Pro Asp Leu  Glu Glu Pro Pro Leu  Lys Glu Glu 
    1280                 1285                 1290             


Asp Glu  Val Pro Asp Asp Glu  Thr Val Asn Gln Met  Ile Ala Arg 
    1295                 1300                 1305             


His Glu  Glu Glu Phe Asp Leu  Phe Met Arg Met Asp  Leu Asp Arg 
    1310                 1315                 1320             


Arg Arg  Glu Glu Ala Arg Asn  Pro Lys Arg Lys Pro  Arg Leu Met 
    1325                 1330                 1335             


Glu Glu  Asp Glu Leu Pro Ser  Trp Ile Ile Lys Asp  Asp Ala Glu 
    1340                 1345                 1350             


Val Glu  Arg Leu Thr Cys Glu  Glu Glu Glu Glu Lys  Met Phe Gly 
    1355                 1360                 1365             


Arg Gly  Ser Arg His Arg Lys  Glu Val Asp Tyr Ser  Asp Ser Leu 
    1370                 1375                 1380             


Thr Glu  Lys Gln Trp Leu Lys  Lys Ile Thr Gly Lys  Asp Ile His 
    1385                 1390                 1395             


Asp Thr  Ala Ser Ser Val Ala  Arg Gly Leu Gln Phe  Gln Arg Gly 
    1400                 1405                 1410             


Leu Gln  Phe Cys Thr Arg Ala  Ser Lys Ala Ile Glu  Glu Gly Thr 
    1415                 1420                 1425             


Leu Glu  Glu Ile Glu Glu Glu  Val Arg Gln Lys Lys  Ser Ser Arg 
    1430                 1435                 1440             


Lys Arg  Lys Arg Asp Ser Asp  Ala Gly Ser Ser Thr  Pro Thr Thr 
    1445                 1450                 1455             


Ser Thr  Arg Ser Arg Asp Lys  Asp Asp Glu Ser Lys  Lys Gln Lys 
    1460                 1465                 1470             


Lys Arg  Gly Arg Pro Pro Ala  Glu Lys Leu Ser Pro  Asn Pro Pro 
    1475                 1480                 1485             


Asn Leu  Thr Lys Lys Met Lys  Lys Ile Val Asp Ala  Val Ile Lys 
    1490                 1495                 1500             


Tyr Lys  Asp Ser Ser Ser Gly  Arg Gln Leu Ser Glu  Val Phe Ile 
    1505                 1510                 1515             


Gln Leu  Pro Ser Arg Lys Glu  Leu Pro Glu Tyr Tyr  Glu Leu Ile 
    1520                 1525                 1530             


Arg Lys  Pro Val Asp Phe Lys  Lys Ile Lys Glu Arg  Ile Arg Asn 
    1535                 1540                 1545             


His Lys  Tyr Arg Ser Leu Asn  Asp Leu Glu Lys Asp  Val Met Leu 
    1550                 1555                 1560             


Leu Cys  Gln Asn Ala Gln Thr  Phe Asn Leu Glu Gly  Ser Leu Ile 
    1565                 1570                 1575             


Tyr Glu  Asp Ser Ile Val Leu  Gln Ser Val Phe Thr  Ser Val Arg 
    1580                 1585                 1590             


Gln Lys  Ile Glu Lys Glu Asp  Asp Ser Glu Gly Glu  Glu Ser Glu 
    1595                 1600                 1605             


Glu Glu  Glu Glu Gly Glu Glu  Glu Gly Ser Glu Ser  Glu Ser Arg 
    1610                 1615                 1620             


Ser Val  Lys Val Lys Ile Lys  Leu Gly Arg Lys Glu  Lys Ala Gln 
    1625                 1630                 1635             


Asp Arg  Leu Lys Gly Gly Arg  Arg Arg Pro Ser Arg  Gly Ser Arg 
    1640                 1645                 1650             


Ala Lys  Pro Val Val Ser Asp  Asp Asp Ser Glu Glu  Glu Gln Glu 
    1655                 1660                 1665             


Glu Asp  Arg Ser Gly Ser Gly  Ser Glu Glu Asp 
    1670                 1675                 


<210> 192
<211> 5589
<212> DNA
<213> Homo sapiens

<400> 192
ggcgggggag gcgccgggaa gtcgacggcg ccggcggctc ctgcaggagg ccactgtctg       60

cagctcccgt gaagatgtcc actccagacc cacccctggg cggaactcct cggccaggtc      120

cttccccggg ccctggccct tcccctggag ccatgctggg ccctagcccg ggtccctcgc      180

cgggctccgc ccacagcatg atggggccca gcccagggcc gccctcagca ggacacccca      240

tccccaccca ggggcctgga gggtaccctc aggacaacat gcaccagatg cacaagccca      300

tggagtccat gcatgagaag ggcatgtcgg acgacccgcg ctacaaccag atgaaaggaa      360

tggggatgcg gtcagggggc catgctggga tggggccccc gcccagcccc atggaccagc      420

actcccaagg ttacccctcg cccctgggtg gctctgagca tgcctctagt ccagttccag      480

ccagtggccc gtcttcgggg ccccagatgt cttccgggcc aggaggtgcc ccgctggatg      540

gtgctgaccc ccaggccttg gggcagcaga accggggccc aaccccattt aaccagaacc      600

agctgcacca gctcagagct cagatcatgg cctacaagat gctggccagg gggcagcccc      660

tccccgacca cctgcagatg gcggtgcagg gcaagcggcc gatgcccggg atgcagcagc      720

agatgccaac gctacctcca ccctcggtgt ccgcaacagg acccggccct ggccctggcc      780

ctggccccgg cccgggtccc ggcccggcac ctccaaatta cagcaggcct catggtatgg      840

gagggcccaa catgcctccc ccaggaccct cgggcgtgcc ccccgggatg ccaggccagc      900

ctcctggagg gcctcccaag ccctggcctg aaggacccat ggcgaatgct gctgccccca      960

cgagcacccc tcagaagctg attcccccgc agccaacggg ccgcccttcc cccgcgcccc     1020

ctgccgtccc acccgccgcc tcgcccgtga tgccaccgca gacccagtcc cccgggcagc     1080

cggcccagcc cgcgcccatg gtgccactgc accagaagca gagccgcatc acccccatcc     1140

agaagccgcg gggcctcgac cctgtggaga tcctgcagga gcgcgagtac aggctgcagg     1200

ctcgcatcgc acaccgaatt caggaacttg aaaaccttcc cgggtccctg gccggggatt     1260

tgcgaaccaa agcgaccatt gagctcaagg ccctcaggct gctgaacttc cagaggcagc     1320

tgcgccagga ggtggtggtg tgcatgcgga gggacacagc gctggagaca gccctcaatg     1380

ctaaggccta caagcgcagc aagcgccagt ccctgcgcga ggcccgcatc actgagaagc     1440

tggagaagca gcagaagatc gagcaggagc gcaagcgccg gcagaagcac caggaatacc     1500

tcaatagcat tctccagcat gccaaggatt tcaaggaata tcacagatcc gtcacaggca     1560

aaatccagaa gctgaccaag gcagtggcca cgtaccatgc caacacggag cgggagcaga     1620

agaaagagaa cgagcggatc gagaaggagc gcatgcggag gctcatggct gaagatgagg     1680

aggggtaccg caagctcatc gaccagaaga aggacaagcg cctggcctac ctcttgcagc     1740

agacagacga gtacgtggct aacctcacgg agctggtgcg gcagcacaag gctgcccagg     1800

tcgccaagga gaaaaagaag aaaaagaaaa agaagaaggc agaaaatgca gaaggacaga     1860

cgcctgccat tgggccggat ggcgagcctc tggacgagac cagccagatg agcgacctcc     1920

cggtgaaggt gatccacgtg gagagtggga agatcctcac aggcacagat gcccccaaag     1980

ccgggcagct ggaggcctgg ctcgagatga acccggggta tgaagtagct ccgaggtctg     2040

atagtgaaga aagtggctca gaagaagagg aagaggagga ggaggaagag cagccgcagg     2100

cagcacagcc tcccaccctg cccgtggagg agaagaagaa gattccagat ccagacagcg     2160

atgacgtctc tgaggtggac gcgcggcaca tcattgagaa tgccaagcaa gatgtcgatg     2220

atgaatatgg cgtgtcccag gcccttgcac gtggcctgca gtcctactat gccgtggccc     2280

atgctgtcac tgagagagtg gacaagcagt cagcgcttat ggtcaatggt gtcctcaaac     2340

agtaccagat caaaggtttg gagtggctgg tgtccctgta caacaacaac ctgaacggca     2400

tcctggccga cgagatgggc ctggggaaga ccatccagac catcgcgctc atcacgtacc     2460

tcatggagca caaacgcatc aatgggccct tcctcatcat cgtgcctctc tcaacgctgt     2520

ccaactgggc gtacgagttt gacaagtggg ccccctccgt ggtgaaggtg tcttacaagg     2580

gatccccagc agcaagacgg gcctttgtcc cccagctccg gagtgggaag ttcaacgtct     2640

tgctgacgac gtacgagtac atcatcaaag acaagcacat cctcgccaag atccgttgga     2700

agtacatgat tgtggacgaa ggtcaccgca tgaagaacca ccactgcaag ctgacgcagg     2760

tgctcaacac gcactatgtg gcaccccgcc gcctgctgct gacgggcaca ccgctgcaga     2820

acaagcttcc cgagctctgg gcgctgctca acttcctgct gcccaccatc ttcaagagct     2880

gcagcacctt cgagcagtgg tttaacgcac cctttgccat gaccggggaa aaggtggacc     2940

tgaatgagga ggaaaccatt ctcatcatcc ggcgtctcca caaagtgctg cggcccttct     3000

tgctccgacg actcaagaag gaagtcgagg cccagttgcc cgaaaaggtg gagtacgtca     3060

tcaagtgcga catgtctgcg ctgcagcgag tgctctaccg ccacatgcag gccaagggcg     3120

tgctgctgac tgatggctcc gagaaggaca agaagggcaa aggcggcacc aagaccctga     3180

tgaacaccat catgcagctg cggaagatct gcaaccaccc ctacatgttc cagcacatcg     3240

aggagtcctt ttccgagcac ttggggttca ctggcggcat tgtccaaggg ctggacctgt     3300

accgagcctc gggtaaattt gagcttcttg atagaattct tcccaaactc cgagcaacca     3360

accacaaagt gctgctgttc tgccaaatga cctccctcat gaccatcatg gaagattact     3420

ttgcgtatcg cggctttaaa tacctcaggc ttgatggaac cacgaaggcg gaggaccggg     3480

gcatgctgct gaaaaccttc aacgagcccg gctctgagta cttcatcttc ctgctcagca     3540

cccgggctgg ggggctcggc ctgaacctcc agtcggcaga cactgtgatc atttttgaca     3600

gcgactggaa tcctcaccag gacctgcaag cgcaggaccg agcccaccgc atcgggcagc     3660

agaacgaggt gcgtgtgctc cgcctctgca ccgtcaacag cgtggaggag aagatcctag     3720

ctgcagccaa gtacaagctc aacgtggacc agaaggtgat ccaggccggc atgttcgacc     3780

agaagtcctc cagccatgag cggcgcgcct tcctgcaggc catcctggag cacgaggagc     3840

aggatgagag cagacactgc agcacgggca gcggcagtgc cagcttcgcc cacactgccc     3900

ctccgccagc gggcgtcaac cccgacttgg aggagccacc tctaaaggag gaagacgagg     3960

tgcccgacga cgagaccgtc aaccagatga tcgcccggca cgaggaggag tttgatctgt     4020

tcatgcgcat ggacctggac cgcaggcgcg aggaggcccg caaccccaag cggaagccgc     4080

gcctcatgga ggaggacgag ctcccctcgt ggatcatcaa ggacgacgcg gaggtggagc     4140

ggctgacctg tgaggaggag gaggagaaga tgttcggccg tggctcccgc caccgcaagg     4200

aggtggacta cagcgactca ctgacggaga agcagtggct caagaaaatt acaggaaaag     4260

atatccatga cacagccagc agtgtggcac gtgggctaca attccagcgt ggccttcagt     4320

tctgcacacg tgcgtcaaag gccatcgagg agggcacgct ggaggagatc gaagaggagg     4380

tccggcagaa gaaatcatca cggaagcgca agcgagacag cgacgccggc tcctccaccc     4440

cgaccaccag cacccgcagc cgcgacaagg acgacgagag caagaagcag aagaagcgcg     4500

ggcggccgcc tgccgagaaa ctctccccta acccacccaa cctcaccaag aagatgaaga     4560

agattgtgga tgccgtgatc aagtacaagg acagcagcag tggacgtcag ctcagcgagg     4620

tcttcatcca gctgccctcg cgaaaggagc tgcccgagta ctacgagctc atccgcaagc     4680

ccgtggactt caagaagata aaggagcgca ttcgcaacca caagtaccgc agcctcaacg     4740

acctagagaa ggacgtcatg ctcctgtgcc agaacgcaca gaccttcaac ctggagggct     4800

ccctgatcta tgaagactcc atcgtcttgc agtcggtctt caccagcgtg cggcagaaaa     4860

tcgagaagga ggatgacagt gaaggcgagg agagtgagga ggaggaagag ggcgaggagg     4920

aaggctccga atccgaatct cggtccgtca aagtgaagat caagcttggc cggaaggaga     4980

aggcacagga ccggctgaag ggcggccggc ggcggccgag ccgagggtcc cgagccaagc     5040

cggtcgtgag tgacgatgac agtgaggagg aacaagagga ggaccgctca ggaagtggca     5100

gcgaagaaga ctgagccccg acattccagt ctcgaccccg agcccctcgt tccagagctg     5160

agatggcata ggccttagca gtaacgggta gcagcagatg tagtttcaga cttggagtaa     5220

aactgtataa acaaaagaat cttccatatt tatacagcag agaagctgta ggactgtttg     5280

tgactggccc tgtcctggca tcagtagcat ctgtaacagc attaactgtc ttaaagagag     5340

agagagagaa ttccgaattg gggaacacac gatacctgtt tttcttttcc gttgctggca     5400

gtactgttgc gccgcagttt ggagtcactg tagttaagtg tggatgcatg tgcgtcaccg     5460

tccactcctc ctactgtatt ttattggaca ggtcagactc gccgggggcc cggcgagggt     5520

atgtcagtgt cactggatgt caaacagtaa taaattaaac caacaacaaa acgcacagcc     5580

aaaaaaaaa                                                             5589


<210> 193
<211> 1647
<212> PRT
<213> Homo sapiens

<400> 193
Met Ser Thr Pro Asp Pro Pro Leu Gly Gly Thr Pro Arg Pro Gly Pro 
1               5                   10                  15      


Ser Pro Gly Pro Gly Pro Ser Pro Gly Ala Met Leu Gly Pro Ser Pro 
            20                  25                  30          


Gly Pro Ser Pro Gly Ser Ala His Ser Met Met Gly Pro Ser Pro Gly 
        35                  40                  45              


Pro Pro Ser Ala Gly His Pro Ile Pro Thr Gln Gly Pro Gly Gly Tyr 
    50                  55                  60                  


Pro Gln Asp Asn Met His Gln Met His Lys Pro Met Glu Ser Met His 
65                  70                  75                  80  


Glu Lys Gly Met Ser Asp Asp Pro Arg Tyr Asn Gln Met Lys Gly Met 
                85                  90                  95      


Gly Met Arg Ser Gly Gly His Ala Gly Met Gly Pro Pro Pro Ser Pro 
            100                 105                 110         


Met Asp Gln His Ser Gln Gly Tyr Pro Ser Pro Leu Gly Gly Ser Glu 
        115                 120                 125             


His Ala Ser Ser Pro Val Pro Ala Ser Gly Pro Ser Ser Gly Pro Gln 
    130                 135                 140                 


Met Ser Ser Gly Pro Gly Gly Ala Pro Leu Asp Gly Ala Asp Pro Gln 
145                 150                 155                 160 


Ala Leu Gly Gln Gln Asn Arg Gly Pro Thr Pro Phe Asn Gln Asn Gln 
                165                 170                 175     


Leu His Gln Leu Arg Ala Gln Ile Met Ala Tyr Lys Met Leu Ala Arg 
            180                 185                 190         


Gly Gln Pro Leu Pro Asp His Leu Gln Met Ala Val Gln Gly Lys Arg 
        195                 200                 205             


Pro Met Pro Gly Met Gln Gln Gln Met Pro Thr Leu Pro Pro Pro Ser 
    210                 215                 220                 


Val Ser Ala Thr Gly Pro Gly Pro Gly Pro Gly Pro Gly Pro Gly Pro 
225                 230                 235                 240 


Gly Pro Gly Pro Ala Pro Pro Asn Tyr Ser Arg Pro His Gly Met Gly 
                245                 250                 255     


Gly Pro Asn Met Pro Pro Pro Gly Pro Ser Gly Val Pro Pro Gly Met 
            260                 265                 270         


Pro Gly Gln Pro Pro Gly Gly Pro Pro Lys Pro Trp Pro Glu Gly Pro 
        275                 280                 285             


Met Ala Asn Ala Ala Ala Pro Thr Ser Thr Pro Gln Lys Leu Ile Pro 
    290                 295                 300                 


Pro Gln Pro Thr Gly Arg Pro Ser Pro Ala Pro Pro Ala Val Pro Pro 
305                 310                 315                 320 


Ala Ala Ser Pro Val Met Pro Pro Gln Thr Gln Ser Pro Gly Gln Pro 
                325                 330                 335     


Ala Gln Pro Ala Pro Met Val Pro Leu His Gln Lys Gln Ser Arg Ile 
            340                 345                 350         


Thr Pro Ile Gln Lys Pro Arg Gly Leu Asp Pro Val Glu Ile Leu Gln 
        355                 360                 365             


Glu Arg Glu Tyr Arg Leu Gln Ala Arg Ile Ala His Arg Ile Gln Glu 
    370                 375                 380                 


Leu Glu Asn Leu Pro Gly Ser Leu Ala Gly Asp Leu Arg Thr Lys Ala 
385                 390                 395                 400 


Thr Ile Glu Leu Lys Ala Leu Arg Leu Leu Asn Phe Gln Arg Gln Leu 
                405                 410                 415     


Arg Gln Glu Val Val Val Cys Met Arg Arg Asp Thr Ala Leu Glu Thr 
            420                 425                 430         


Ala Leu Asn Ala Lys Ala Tyr Lys Arg Ser Lys Arg Gln Ser Leu Arg 
        435                 440                 445             


Glu Ala Arg Ile Thr Glu Lys Leu Glu Lys Gln Gln Lys Ile Glu Gln 
    450                 455                 460                 


Glu Arg Lys Arg Arg Gln Lys His Gln Glu Tyr Leu Asn Ser Ile Leu 
465                 470                 475                 480 


Gln His Ala Lys Asp Phe Lys Glu Tyr His Arg Ser Val Thr Gly Lys 
                485                 490                 495     


Ile Gln Lys Leu Thr Lys Ala Val Ala Thr Tyr His Ala Asn Thr Glu 
            500                 505                 510         


Arg Glu Gln Lys Lys Glu Asn Glu Arg Ile Glu Lys Glu Arg Met Arg 
        515                 520                 525             


Arg Leu Met Ala Glu Asp Glu Glu Gly Tyr Arg Lys Leu Ile Asp Gln 
    530                 535                 540                 


Lys Lys Asp Lys Arg Leu Ala Tyr Leu Leu Gln Gln Thr Asp Glu Tyr 
545                 550                 555                 560 


Val Ala Asn Leu Thr Glu Leu Val Arg Gln His Lys Ala Ala Gln Val 
                565                 570                 575     


Ala Lys Glu Lys Lys Lys Lys Lys Lys Lys Lys Lys Ala Glu Asn Ala 
            580                 585                 590         


Glu Gly Gln Thr Pro Ala Ile Gly Pro Asp Gly Glu Pro Leu Asp Glu 
        595                 600                 605             


Thr Ser Gln Met Ser Asp Leu Pro Val Lys Val Ile His Val Glu Ser 
    610                 615                 620                 


Gly Lys Ile Leu Thr Gly Thr Asp Ala Pro Lys Ala Gly Gln Leu Glu 
625                 630                 635                 640 


Ala Trp Leu Glu Met Asn Pro Gly Tyr Glu Val Ala Pro Arg Ser Asp 
                645                 650                 655     


Ser Glu Glu Ser Gly Ser Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu 
            660                 665                 670         


Gln Pro Gln Ala Ala Gln Pro Pro Thr Leu Pro Val Glu Glu Lys Lys 
        675                 680                 685             


Lys Ile Pro Asp Pro Asp Ser Asp Asp Val Ser Glu Val Asp Ala Arg 
    690                 695                 700                 


His Ile Ile Glu Asn Ala Lys Gln Asp Val Asp Asp Glu Tyr Gly Val 
705                 710                 715                 720 


Ser Gln Ala Leu Ala Arg Gly Leu Gln Ser Tyr Tyr Ala Val Ala His 
                725                 730                 735     


Ala Val Thr Glu Arg Val Asp Lys Gln Ser Ala Leu Met Val Asn Gly 
            740                 745                 750         


Val Leu Lys Gln Tyr Gln Ile Lys Gly Leu Glu Trp Leu Val Ser Leu 
        755                 760                 765             


Tyr Asn Asn Asn Leu Asn Gly Ile Leu Ala Asp Glu Met Gly Leu Gly 
    770                 775                 780                 


Lys Thr Ile Gln Thr Ile Ala Leu Ile Thr Tyr Leu Met Glu His Lys 
785                 790                 795                 800 


Arg Ile Asn Gly Pro Phe Leu Ile Ile Val Pro Leu Ser Thr Leu Ser 
                805                 810                 815     


Asn Trp Ala Tyr Glu Phe Asp Lys Trp Ala Pro Ser Val Val Lys Val 
            820                 825                 830         


Ser Tyr Lys Gly Ser Pro Ala Ala Arg Arg Ala Phe Val Pro Gln Leu 
        835                 840                 845             


Arg Ser Gly Lys Phe Asn Val Leu Leu Thr Thr Tyr Glu Tyr Ile Ile 
    850                 855                 860                 


Lys Asp Lys His Ile Leu Ala Lys Ile Arg Trp Lys Tyr Met Ile Val 
865                 870                 875                 880 


Asp Glu Gly His Arg Met Lys Asn His His Cys Lys Leu Thr Gln Val 
                885                 890                 895     


Leu Asn Thr His Tyr Val Ala Pro Arg Arg Leu Leu Leu Thr Gly Thr 
            900                 905                 910         


Pro Leu Gln Asn Lys Leu Pro Glu Leu Trp Ala Leu Leu Asn Phe Leu 
        915                 920                 925             


Leu Pro Thr Ile Phe Lys Ser Cys Ser Thr Phe Glu Gln Trp Phe Asn 
    930                 935                 940                 


Ala Pro Phe Ala Met Thr Gly Glu Lys Val Asp Leu Asn Glu Glu Glu 
945                 950                 955                 960 


Thr Ile Leu Ile Ile Arg Arg Leu His Lys Val Leu Arg Pro Phe Leu 
                965                 970                 975     


Leu Arg Arg Leu Lys Lys Glu Val Glu Ala Gln Leu Pro Glu Lys Val 
            980                 985                 990         


Glu Tyr Val Ile Lys Cys Asp Met  Ser Ala Leu Gln Arg  Val Leu Tyr 
        995                 1000                 1005             


Arg His  Met Gln Ala Lys Gly  Val Leu Leu Thr Asp  Gly Ser Glu 
    1010                 1015                 1020             


Lys Asp  Lys Lys Gly Lys Gly  Gly Thr Lys Thr Leu  Met Asn Thr 
    1025                 1030                 1035             


Ile Met  Gln Leu Arg Lys Ile  Cys Asn His Pro Tyr  Met Phe Gln 
    1040                 1045                 1050             


His Ile  Glu Glu Ser Phe Ser  Glu His Leu Gly Phe  Thr Gly Gly 
    1055                 1060                 1065             


Ile Val  Gln Gly Leu Asp Leu  Tyr Arg Ala Ser Gly  Lys Phe Glu 
    1070                 1075                 1080             


Leu Leu  Asp Arg Ile Leu Pro  Lys Leu Arg Ala Thr  Asn His Lys 
    1085                 1090                 1095             


Val Leu  Leu Phe Cys Gln Met  Thr Ser Leu Met Thr  Ile Met Glu 
    1100                 1105                 1110             


Asp Tyr  Phe Ala Tyr Arg Gly  Phe Lys Tyr Leu Arg  Leu Asp Gly 
    1115                 1120                 1125             


Thr Thr  Lys Ala Glu Asp Arg  Gly Met Leu Leu Lys  Thr Phe Asn 
    1130                 1135                 1140             


Glu Pro  Gly Ser Glu Tyr Phe  Ile Phe Leu Leu Ser  Thr Arg Ala 
    1145                 1150                 1155             


Gly Gly  Leu Gly Leu Asn Leu  Gln Ser Ala Asp Thr  Val Ile Ile 
    1160                 1165                 1170             


Phe Asp  Ser Asp Trp Asn Pro  His Gln Asp Leu Gln  Ala Gln Asp 
    1175                 1180                 1185             


Arg Ala  His Arg Ile Gly Gln  Gln Asn Glu Val Arg  Val Leu Arg 
    1190                 1195                 1200             


Leu Cys  Thr Val Asn Ser Val  Glu Glu Lys Ile Leu  Ala Ala Ala 
    1205                 1210                 1215             


Lys Tyr  Lys Leu Asn Val Asp  Gln Lys Val Ile Gln  Ala Gly Met 
    1220                 1225                 1230             


Phe Asp  Gln Lys Ser Ser Ser  His Glu Arg Arg Ala  Phe Leu Gln 
    1235                 1240                 1245             


Ala Ile  Leu Glu His Glu Glu  Gln Asp Glu Ser Arg  His Cys Ser 
    1250                 1255                 1260             


Thr Gly  Ser Gly Ser Ala Ser  Phe Ala His Thr Ala  Pro Pro Pro 
    1265                 1270                 1275             


Ala Gly  Val Asn Pro Asp Leu  Glu Glu Pro Pro Leu  Lys Glu Glu 
    1280                 1285                 1290             


Asp Glu  Val Pro Asp Asp Glu  Thr Val Asn Gln Met  Ile Ala Arg 
    1295                 1300                 1305             


His Glu  Glu Glu Phe Asp Leu  Phe Met Arg Met Asp  Leu Asp Arg 
    1310                 1315                 1320             


Arg Arg  Glu Glu Ala Arg Asn  Pro Lys Arg Lys Pro  Arg Leu Met 
    1325                 1330                 1335             


Glu Glu  Asp Glu Leu Pro Ser  Trp Ile Ile Lys Asp  Asp Ala Glu 
    1340                 1345                 1350             


Val Glu  Arg Leu Thr Cys Glu  Glu Glu Glu Glu Lys  Met Phe Gly 
    1355                 1360                 1365             


Arg Gly  Ser Arg His Arg Lys  Glu Val Asp Tyr Ser  Asp Ser Leu 
    1370                 1375                 1380             


Thr Glu  Lys Gln Trp Leu Lys  Ala Ile Glu Glu Gly  Thr Leu Glu 
    1385                 1390                 1395             


Glu Ile  Glu Glu Glu Val Arg  Gln Lys Lys Ser Ser  Arg Lys Arg 
    1400                 1405                 1410             


Lys Arg  Asp Ser Asp Ala Gly  Ser Ser Thr Pro Thr  Thr Ser Thr 
    1415                 1420                 1425             


Arg Ser  Arg Asp Lys Asp Asp  Glu Ser Lys Lys Gln  Lys Lys Arg 
    1430                 1435                 1440             


Gly Arg  Pro Pro Ala Glu Lys  Leu Ser Pro Asn Pro  Pro Asn Leu 
    1445                 1450                 1455             


Thr Lys  Lys Met Lys Lys Ile  Val Asp Ala Val Ile  Lys Tyr Lys 
    1460                 1465                 1470             


Asp Ser  Ser Ser Gly Arg Gln  Leu Ser Glu Val Phe  Ile Gln Leu 
    1475                 1480                 1485             


Pro Ser  Arg Lys Glu Leu Pro  Glu Tyr Tyr Glu Leu  Ile Arg Lys 
    1490                 1495                 1500             


Pro Val  Asp Phe Lys Lys Ile  Lys Glu Arg Ile Arg  Asn His Lys 
    1505                 1510                 1515             


Tyr Arg  Ser Leu Asn Asp Leu  Glu Lys Asp Val Met  Leu Leu Cys 
    1520                 1525                 1530             


Gln Asn  Ala Gln Thr Phe Asn  Leu Glu Gly Ser Leu  Ile Tyr Glu 
    1535                 1540                 1545             


Asp Ser  Ile Val Leu Gln Ser  Val Phe Thr Ser Val  Arg Gln Lys 
    1550                 1555                 1560             


Ile Glu  Lys Glu Asp Asp Ser  Glu Gly Glu Glu Ser  Glu Glu Glu 
    1565                 1570                 1575             


Glu Glu  Gly Glu Glu Glu Gly  Ser Glu Ser Glu Ser  Arg Ser Val 
    1580                 1585                 1590             


Lys Val  Lys Ile Lys Leu Gly  Arg Lys Glu Lys Ala  Gln Asp Arg 
    1595                 1600                 1605             


Leu Lys  Gly Gly Arg Arg Arg  Pro Ser Arg Gly Ser  Arg Ala Lys 
    1610                 1615                 1620             


Pro Val  Val Ser Asp Asp Asp  Ser Glu Glu Glu Gln  Glu Glu Asp 
    1625                 1630                 1635             


Arg Ser  Gly Ser Gly Ser Glu  Glu Asp 
    1640                 1645         


<210> 194
<211> 5779
<212> DNA
<213> Homo sapiens

<400> 194
ggagaggccg ccgcggtgct gagggggagg ggagccggcg agcgcgcgcg cagcgggggc       60

gcgggtggcg cgcgtgtgtg tgaagggggg gcggtggccg aggcgggcgg gcgcgcgcgc      120

gaggcttccc ctcgtttggc ggcggcggcg gcttctttgt ttcgtgaaga gaagcgagac      180

gcccattctg cccccggccc cgcgcggagg ggcgggggag gcgccgggaa gtcgacggcg      240

ccggcggctc ctgcgtctcg cccttttgcc caggctagag tgcagtggtg cggtcatggt      300

tcactgcagc ctcaacctcc tggactcagc aggaggccac tgtctgcagc tcccgtgaag      360

atgtccactc cagacccacc cctgggcgga actcctcggc caggtccttc cccgggccct      420

ggcccttccc ctggagccat gctgggccct agcccgggtc cctcgccggg ctccgcccac      480

agcatgatgg ggcccagccc agggccgccc tcagcaggac accccatccc cacccagggg      540

cctggagggt accctcagga caacatgcac cagatgcaca agcccatgga gtccatgcat      600

gagaagggca tgtcggacga cccgcgctac aaccagatga aaggaatggg gatgcggtca      660

gggggccatg ctgggatggg gcccccgccc agccccatgg accagcactc ccaaggttac      720

ccctcgcccc tgggtggctc tgagcatgcc tctagtccag ttccagccag tggcccgtct      780

tcggggcccc agatgtcttc cgggccagga ggtgccccgc tggatggtgc tgacccccag      840

gccttggggc agcagaaccg gggcccaacc ccatttaacc agaaccagct gcaccagctc      900

agagctcaga tcatggccta caagatgctg gccagggggc agcccctccc cgaccacctg      960

cagatggcgg tgcagggcaa gcggccgatg cccgggatgc agcagcagat gccaacgcta     1020

cctccaccct cggtgtccgc aacaggaccc ggccctggcc ctggccctgg ccccggcccg     1080

ggtcccggcc cggcacctcc aaattacagc aggcctcatg gtatgggagg gcccaacatg     1140

cctcccccag gaccctcggg cgtgcccccc gggatgccag gccagcctcc tggagggcct     1200

cccaagccct ggcctgaagg acccatggcg aatgctgctg cccccacgag cacccctcag     1260

aagctgattc ccccgcagcc aacgggccgc ccttcccccg cgccccctgc cgtcccaccc     1320

gccgcctcgc ccgtgatgcc accgcagacc cagtcccccg ggcagccggc ccagcccgcg     1380

cccatggtgc cactgcacca gaagcagagc cgcatcaccc ccatccagaa gccgcggggc     1440

ctcgaccctg tggagatcct gcaggagcgc gagtacaggc tgcaggctcg catcgcacac     1500

cgaattcagg aacttgaaaa ccttcccggg tccctggccg gggatttgcg aaccaaagcg     1560

accattgagc tcaaggccct caggctgctg aacttccaga ggcagctgcg ccaggaggtg     1620

gtggtgtgca tgcggaggga cacagcgctg gagacagccc tcaatgctaa ggcctacaag     1680

cgcagcaagc gccagtccct gcgcgaggcc cgcatcactg agaagctgga gaagcagcag     1740

aagatcgagc aggagcgcaa gcgccggcag aagcaccagg aatacctcaa tagcattctc     1800

cagcatgcca aggatttcaa ggaatatcac agatccgtca caggcaaaat ccagaagctg     1860

accaaggcag tggccacgta ccatgccaac acggagcggg agcagaagaa agagaacgag     1920

cggatcgaga aggagcgcat gcggaggctc atggctgaag atgaggaggg gtaccgcaag     1980

ctcatcgacc agaagaagga caagcgcctg gcctacctct tgcagcagac agacgagtac     2040

gtggctaacc tcacggagct ggtgcggcag cacaaggctg cccaggtcgc caaggagaaa     2100

aagaagaaaa agaaaaagaa gaaggcagaa aatgcagaag gacagacgcc tgccattggg     2160

ccggatggcg agcctctgga cgagaccagc cagatgagcg acctcccggt gaaggtgatc     2220

cacgtggaga gtgggaagat cctcacaggc acagatgccc ccaaagccgg gcagctggag     2280

gcctggctcg agatgaaccc ggggtatgaa gtagctccga ggtctgatag tgaagaaagt     2340

ggctcagaag aagaggaaga ggaggaggag gaagagcagc cgcaggcagc acagcctccc     2400

accctgcccg tggaggagaa gaagaagatt ccagatccag acagcgatga cgtctctgag     2460

gtggacgcgc ggcacatcat tgagaatgcc aagcaagatg tcgatgatga atatggcgtg     2520

tcccaggccc ttgcacgtgg cctgcagtcc tactatgccg tggcccatgc tgtcactgag     2580

agagtggaca agcagtcagc gcttatggtc aatggtgtcc tcaaacagta ccagatcaaa     2640

ggtttggagt ggctggtgtc cctgtacaac aacaacctga acggcatcct ggccgacgag     2700

atgggcctgg ggaagaccat ccagaccatc gcgctcatca cgtacctcat ggagcacaaa     2760

cgcatcaatg ggcccttcct catcatcgtg cctctctcaa cgctgtccaa ctgggcgtac     2820

gagtttgaca agtgggcccc ctccgtggtg aaggtgtctt acaagggatc cccagcagca     2880

agacgggcct ttgtccccca gctccggagt gggaagttca acgtcttgct gacgacgtac     2940

gagtacatca tcaaagacaa gcacatcctc gccaagatcc gttggaagta catgattgtg     3000

gacgaaggtc accgcatgaa gaaccaccac tgcaagctga cgcaggtgct caacacgcac     3060

tatgtggcac cccgccgcct gctgctgacg ggcacaccgc tgcagaacaa gcttcccgag     3120

ctctgggcgc tgctcaactt cctgctgccc accatcttca agagctgcag caccttcgag     3180

cagtggttta acgcaccctt tgccatgacc ggggaaaagg tggacctgaa tgaggaggaa     3240

accattctca tcatccggcg tctccacaaa gtgctgcggc ccttcttgct ccgacgactc     3300

aagaaggaag tcgaggccca gttgcccgaa aaggtggagt acgtcatcaa gtgcgacatg     3360

tctgcgctgc agcgagtgct ctaccgccac atgcaggcca agggcgtgct gctgactgat     3420

ggctccgaga aggacaagaa gggcaaaggc ggcaccaaga ccctgatgaa caccatcatg     3480

cagctgcgga agatctgcaa ccacccctac atgttccagc acatcgagga gtccttttcc     3540

gagcacttgg ggttcactgg cggcattgtc caagggctgg acctgtaccg agcctcgggt     3600

aaatttgagc ttcttgatag aattcttccc aaactccgag caaccaacca caaagtgctg     3660

ctgttctgcc aaatgacctc cctcatgacc atcatggaag attactttgc gtatcgcggc     3720

tttaaatacc tcaggcttga tggaaccacg aaggcggagg accggggcat gctgctgaaa     3780

accttcaacg agcccggctc tgagtacttc atcttcctgc tcagcacccg ggctgggggg     3840

ctcggcctga acctccagtc ggcagacact gtgatcattt ttgacagcga ctggaatcct     3900

caccaggacc tgcaagcgca ggaccgagcc caccgcatcg ggcagcagaa cgaggtgcgt     3960

gtgctccgcc tctgcaccgt caacagcgtg gaggagaaga tcctagctgc agccaagtac     4020

aagctcaacg tggaccagaa ggtgatccag gccggcatgt tcgaccagaa gtcctccagc     4080

catgagcggc gcgccttcct gcaggccatc ctggagcacg aggagcagga tgagagcaga     4140

cactgcagca cgggcagcgg cagtgccagc ttcgcccaca ctgcccctcc gccagcgggc     4200

gtcaaccccg acttggagga gccacctcta aaggaggaag acgaggtgcc cgacgacgag     4260

accgtcaacc agatgatcgc ccggcacgag gaggagtttg atctgttcat gcgcatggac     4320

ctggaccgca ggcgcgagga ggcccgcaac cccaagcgga agccgcgcct catggaggag     4380

gacgagctcc cctcgtggat catcaaggac gacgcggagg tggagcggct gacctgtgag     4440

gaggaggagg agaagatgtt cggccgtggc tcccgccacc gcaaggaggt ggactacagc     4500

gactcactga cggagaagca gtggctcaag gccatcgagg agggcacgct ggaggagatc     4560

gaagaggagg tccggcagaa gaaatcatca cggaagcgca agcgagacag cgacgccggc     4620

tcctccaccc cgaccaccag cacccgcagc cgcgacaagg acgacgagag caagaagcag     4680

aagaagcgcg ggcggccgcc tgccgagaaa ctctccccta acccacccaa cctcaccaag     4740

aagatgaaga agattgtgga tgccgtgatc aagtacaagg acagcagcag tggacgtcag     4800

ctcagcgagg tcttcatcca gctgccctcg cgaaaggagc tgcccgagta ctacgagctc     4860

atccgcaagc ccgtggactt caagaagata aaggagcgca ttcgcaacca caagtaccgc     4920

agcctcaacg acctagagaa ggacgtcatg ctcctgtgcc agaacgcaca gaccttcaac     4980

ctggagggct ccctgatcta tgaagactcc atcgtcttgc agtcggtctt caccagcgtg     5040

cggcagaaaa tcgagaagga ggatgacagt gaaggcgagg agagtgagga ggaggaagag     5100

ggcgaggagg aaggctccga atccgaatct cggtccgtca aagtgaagat caagcttggc     5160

cggaaggaga aggcacagga ccggctgaag ggcggccggc ggcggccgag ccgagggtcc     5220

cgagccaagc cggtcgtgag tgacgatgac agtgaggagg aacaagagga ggaccgctca     5280

ggaagtggca gcgaagaaga ctgagccccg acattccagt ctcgaccccg agcccctcgt     5340

tccagagctg agatggcata ggccttagca gtaacgggta gcagcagatg tagtttcaga     5400

cttggagtaa aactgtataa acaaaagaat cttccatatt tatacagcag agaagctgta     5460

ggactgtttg tgactggccc tgtcctggca tcagtagcat ctgtaacagc attaactgtc     5520

ttaaagagag agagagagaa ttccgaattg gggaacacac gatacctgtt tttcttttcc     5580

gttgctggca gtactgttgc gccgcagttt ggagtcactg tagttaagtg tggatgcatg     5640

tgcgtcaccg tccactcctc ctactgtatt ttattggaca ggtcagactc gccgggggcc     5700

cggcgagggt atgtcagtgt cactggatgt caaacagtaa taaattaaac caacaacaaa     5760

acgcacagcc aaaaaaaaa                                                  5779


<210> 195
<211> 5703
<212> DNA
<213> Homo sapiens

<400> 195
ggagaggccg ccgcggtgct gagggggagg ggagccggcg agcgcgcgcg cagcgggggc       60

gcgggtggcg cgcgtgtgtg tgaagggggg gcggtggccg aggcgggcgg gcgcgcgcgc      120

gaggcttccc ctcgtttggc ggcggcggcg gcttctttgt ttcgtgaaga gaagcgagac      180

gcccattctg cccccggccc cgcgcggagg ggcgggggag gcgccgggaa gtcgacggcg      240

ccggcggctc ctgcaggagg ccactgtctg cagctcccgt gaagatgtcc actccagacc      300

cacccctggg cggaactcct cggccaggtc cttccccggg ccctggccct tcccctggag      360

ccatgctggg ccctagcccg ggtccctcgc cgggctccgc ccacagcatg atggggccca      420

gcccagggcc gccctcagca ggacacccca tccccaccca ggggcctgga gggtaccctc      480

aggacaacat gcaccagatg cacaagccca tggagtccat gcatgagaag ggcatgtcgg      540

acgacccgcg ctacaaccag atgaaaggaa tggggatgcg gtcagggggc catgctggga      600

tggggccccc gcccagcccc atggaccagc actcccaagg ttacccctcg cccctgggtg      660

gctctgagca tgcctctagt ccagttccag ccagtggccc gtcttcgggg ccccagatgt      720

cttccgggcc aggaggtgcc ccgctggatg gtgctgaccc ccaggccttg gggcagcaga      780

accggggccc aaccccattt aaccagaacc agctgcacca gctcagagct cagatcatgg      840

cctacaagat gctggccagg gggcagcccc tccccgacca cctgcagatg gcggtgcagg      900

gcaagcggcc gatgcccggg atgcagcagc agatgccaac gctacctcca ccctcggtgt      960

ccgcaacagg acccggccct ggccctggcc ctggccccgg cccgggtccc ggcccggcac     1020

ctccaaatta cagcaggcct catggtatgg gagggcccaa catgcctccc ccaggaccct     1080

cgggcgtgcc ccccgggatg ccaggccagc ctcctggagg gcctcccaag ccctggcctg     1140

aaggacccat ggcgaatgct gctgccccca cgagcacccc tcagaagctg attcccccgc     1200

agccaacggg ccgcccttcc cccgcgcccc ctgccgtccc acccgccgcc tcgcccgtga     1260

tgccaccgca gacccagtcc cccgggcagc cggcccagcc cgcgcccatg gtgccactgc     1320

accagaagca gagccgcatc acccccatcc agaagccgcg gggcctcgac cctgtggaga     1380

tcctgcagga gcgcgagtac aggctgcagg ctcgcatcgc acaccgaatt caggaacttg     1440

aaaaccttcc cgggtccctg gccggggatt tgcgaaccaa agcgaccatt gagctcaagg     1500

ccctcaggct gctgaacttc cagaggcagc tgcgccagga ggtggtggtg tgcatgcgga     1560

gggacacagc gctggagaca gccctcaatg ctaaggccta caagcgcagc aagcgccagt     1620

ccctgcgcga ggcccgcatc actgagaagc tggagaagca gcagaagatc gagcaggagc     1680

gcaagcgccg gcagaagcac caggaatacc tcaatagcat tctccagcat gccaaggatt     1740

tcaaggaata tcacagatcc gtcacaggca aaatccagaa gctgaccaag gcagtggcca     1800

cgtaccatgc caacacggag cgggagcaga agaaagagaa cgagcggatc gagaaggagc     1860

gcatgcggag gctcatggct gaagatgagg aggggtaccg caagctcatc gaccagaaga     1920

aggacaagcg cctggcctac ctcttgcagc agacagacga gtacgtggct aacctcacgg     1980

agctggtgcg gcagcacaag gctgcccagg tcgccaagga gaaaaagaag aaaaagaaaa     2040

agaagaaggc agaaaatgca gaaggacaga cgcctgccat tgggccggat ggcgagcctc     2100

tggacgagac cagccagatg agcgacctcc cggtgaaggt gatccacgtg gagagtggga     2160

agatcctcac aggcacagat gcccccaaag ccgggcagct ggaggcctgg ctcgagatga     2220

acccggggta tgaagtagct ccgaggtctg atagtgaaga aagtggctca gaagaagagg     2280

aagaggagga ggaggaagag cagccgcagg cagcacagcc tcccaccctg cccgtggagg     2340

agaagaagaa gattccagat ccagacagcg atgacgtctc tgaggtggac gcgcggcaca     2400

tcattgagaa tgccaagcaa gatgtcgatg atgaatatgg cgtgtcccag gcccttgcac     2460

gtggcctgca gtcctactat gccgtggccc atgctgtcac tgagagagtg gacaagcagt     2520

cagcgcttat ggtcaatggt gtcctcaaac agtaccagat caaaggtttg gagtggctgg     2580

tgtccctgta caacaacaac ctgaacggca tcctggccga cgagatgggc ctggggaaga     2640

ccatccagac catcgcgctc atcacgtacc tcatggagca caaacgcatc aatgggccct     2700

tcctcatcat cgtgcctctc tcaacgctgt ccaactgggc gtacgagttt gacaagtggg     2760

ccccctccgt ggtgaaggtg tcttacaagg gatccccagc agcaagacgg gcctttgtcc     2820

cccagctccg gagtgggaag ttcaacgtct tgctgacgac gtacgagtac atcatcaaag     2880

acaagcacat cctcgccaag atccgttgga agtacatgat tgtggacgaa ggtcaccgca     2940

tgaagaacca ccactgcaag ctgacgcagg tgctcaacac gcactatgtg gcaccccgcc     3000

gcctgctgct gacgggcaca ccgctgcaga acaagcttcc cgagctctgg gcgctgctca     3060

acttcctgct gcccaccatc ttcaagagct gcagcacctt cgagcagtgg tttaacgcac     3120

cctttgccat gaccggggaa aaggtggacc tgaatgagga ggaaaccatt ctcatcatcc     3180

ggcgtctcca caaagtgctg cggcccttct tgctccgacg actcaagaag gaagtcgagg     3240

cccagttgcc cgaaaaggtg gagtacgtca tcaagtgcga catgtctgcg ctgcagcgag     3300

tgctctaccg ccacatgcag gccaagggcg tgctgctgac tgatggctcc gagaaggaca     3360

agaagggcaa aggcggcacc aagaccctga tgaacaccat catgcagctg cggaagatct     3420

gcaaccaccc ctacatgttc cagcacatcg aggagtcctt ttccgagcac ttggggttca     3480

ctggcggcat tgtccaaggg ctggacctgt accgagcctc gggtaaattt gagcttcttg     3540

atagaattct tcccaaactc cgagcaacca accacaaagt gctgctgttc tgccaaatga     3600

cctccctcat gaccatcatg gaagattact ttgcgtatcg cggctttaaa tacctcaggc     3660

ttgatggaac cacgaaggcg gaggaccggg gcatgctgct gaaaaccttc aacgagcccg     3720

gctctgagta cttcatcttc ctgctcagca cccgggctgg ggggctcggc ctgaacctcc     3780

agtcggcaga cactgtgatc atttttgaca gcgactggaa tcctcaccag gacctgcaag     3840

cgcaggaccg agcccaccgc atcgggcagc agaacgaggt gcgtgtgctc cgcctctgca     3900

ccgtcaacag cgtggaggag aagatcctag ctgcagccaa gtacaagctc aacgtggacc     3960

agaaggtgat ccaggccggc atgttcgacc agaagtcctc cagccatgag cggcgcgcct     4020

tcctgcaggc catcctggag cacgaggagc aggatgagag cagacactgc agcacgggca     4080

gcggcagtgc cagcttcgcc cacactgccc ctccgccagc gggcgtcaac cccgacttgg     4140

aggagccacc tctaaaggag gaagacgagg tgcccgacga cgagaccgtc aaccagatga     4200

tcgcccggca cgaggaggag tttgatctgt tcatgcgcat ggacctggac cgcaggcgcg     4260

aggaggcccg caaccccaag cggaagccgc gcctcatgga ggaggacgag ctcccctcgt     4320

ggatcatcaa ggacgacgcg gaggtggagc ggctgacctg tgaggaggag gaggagaaga     4380

tgttcggccg tggctcccgc caccgcaagg aggtggacta cagcgactca ctgacggaga     4440

agcagtggct caaggccatc gaggagggca cgctggagga gatcgaagag gaggtccggc     4500

agaagaaatc atcacggaag cgcaagcgag acagcgacgc cggctcctcc accccgacca     4560

ccagcacccg cagccgcgac aaggacgacg agagcaagaa gcagaagaag cgcgggcggc     4620

cgcctgccga gaaactctcc cctaacccac ccaacctcac caagaagatg aagaagattg     4680

tggatgccgt gatcaagtac aaggacagca gcagtggacg tcagctcagc gaggtcttca     4740

tccagctgcc ctcgcgaaag gagctgcccg agtactacga gctcatccgc aagcccgtgg     4800

acttcaagaa gataaaggag cgcattcgca accacaagta ccgcagcctc aacgacctag     4860

agaaggacgt catgctcctg tgccagaacg cacagacctt caacctggag ggctccctga     4920

tctatgaaga ctccatcgtc ttgcagtcgg tcttcaccag cgtgcggcag aaaatcgaga     4980

aggaggatga cagtgaaggc gaggagagtg aggaggagga agagggcgag gaggaaggct     5040

ccgaatccga atctcggtcc gtcaaagtga agatcaagct tggccggaag gagaaggcac     5100

aggaccggct gaagggcggc cggcggcggc cgagccgagg gtcccgagcc aagccggtcg     5160

tgagtgacga tgacagtgag gaggaacaag aggaggaccg ctcaggaagt ggcagcgaag     5220

aagactgagc cccgacattc cagtctcgac cccgagcccc tcgttccaga gctgagatgg     5280

cataggcctt agcagtaacg ggtagcagca gatgtagttt cagacttgga gtaaaactgt     5340

ataaacaaaa gaatcttcca tatttataca gcagagaagc tgtaggactg tttgtgactg     5400

gccctgtcct ggcatcagta gcatctgtaa cagcattaac tgtcttaaag agagagagag     5460

agaattccga attggggaac acacgatacc tgtttttctt ttccgttgct ggcagtactg     5520

ttgcgccgca gtttggagtc actgtagtta agtgtggatg catgtgcgtc accgtccact     5580

cctcctactg tattttattg gacaggtcag actcgccggg ggcccggcga gggtatgtca     5640

gtgtcactgg atgtcaaaca gtaataaatt aaaccaacaa caaaacgcac agccaaaaaa     5700

aaa                                                                   5703


<210> 196
<211> 1617
<212> PRT
<213> Homo sapiens

<400> 196
Met Ser Thr Pro Asp Pro Pro Leu Gly Gly Thr Pro Arg Pro Gly Pro 
1               5                   10                  15      


Ser Pro Gly Pro Gly Pro Ser Pro Gly Ala Met Leu Gly Pro Ser Pro 
            20                  25                  30          


Gly Pro Ser Pro Gly Ser Ala His Ser Met Met Gly Pro Ser Pro Gly 
        35                  40                  45              


Pro Pro Ser Ala Gly His Pro Ile Pro Thr Gln Gly Pro Gly Gly Tyr 
    50                  55                  60                  


Pro Gln Asp Asn Met His Gln Met His Lys Pro Met Glu Ser Met His 
65                  70                  75                  80  


Glu Lys Gly Met Ser Asp Asp Pro Arg Tyr Asn Gln Met Lys Gly Met 
                85                  90                  95      


Gly Met Arg Ser Gly Gly His Ala Gly Met Gly Pro Pro Pro Ser Pro 
            100                 105                 110         


Met Asp Gln His Ser Gln Gly Tyr Pro Ser Pro Leu Gly Gly Ser Glu 
        115                 120                 125             


His Ala Ser Ser Pro Val Pro Ala Ser Gly Pro Ser Ser Gly Pro Gln 
    130                 135                 140                 


Met Ser Ser Gly Pro Gly Gly Ala Pro Leu Asp Gly Ala Asp Pro Gln 
145                 150                 155                 160 


Ala Leu Gly Gln Gln Asn Arg Gly Pro Thr Pro Phe Asn Gln Asn Gln 
                165                 170                 175     


Leu His Gln Leu Arg Ala Gln Ile Met Ala Tyr Lys Met Leu Ala Arg 
            180                 185                 190         


Gly Gln Pro Leu Pro Asp His Leu Gln Met Ala Val Gln Gly Lys Arg 
        195                 200                 205             


Pro Met Pro Gly Met Gln Gln Gln Met Pro Thr Leu Pro Pro Pro Ser 
    210                 215                 220                 


Val Ser Ala Thr Gly Pro Gly Pro Gly Pro Gly Pro Gly Pro Gly Pro 
225                 230                 235                 240 


Gly Pro Gly Pro Ala Pro Pro Asn Tyr Ser Arg Pro His Gly Met Gly 
                245                 250                 255     


Gly Pro Asn Met Pro Pro Pro Gly Pro Ser Gly Val Pro Pro Gly Met 
            260                 265                 270         


Pro Gly Gln Pro Pro Gly Gly Pro Pro Lys Pro Trp Pro Glu Gly Pro 
        275                 280                 285             


Met Ala Asn Ala Ala Ala Pro Thr Ser Thr Pro Gln Lys Leu Ile Pro 
    290                 295                 300                 


Pro Gln Pro Thr Gly Arg Pro Ser Pro Ala Pro Pro Ala Val Pro Pro 
305                 310                 315                 320 


Ala Ala Ser Pro Val Met Pro Pro Gln Thr Gln Ser Pro Gly Gln Pro 
                325                 330                 335     


Ala Gln Pro Ala Pro Met Val Pro Leu His Gln Lys Gln Ser Arg Ile 
            340                 345                 350         


Thr Pro Ile Gln Lys Pro Arg Gly Leu Asp Pro Val Glu Ile Leu Gln 
        355                 360                 365             


Glu Arg Glu Tyr Arg Leu Gln Ala Arg Ile Ala His Arg Ile Gln Glu 
    370                 375                 380                 


Leu Glu Asn Leu Pro Gly Ser Leu Ala Gly Asp Leu Arg Thr Lys Ala 
385                 390                 395                 400 


Thr Ile Glu Leu Lys Ala Leu Arg Leu Leu Asn Phe Gln Arg Gln Leu 
                405                 410                 415     


Arg Gln Glu Val Val Val Cys Met Arg Arg Asp Thr Ala Leu Glu Thr 
            420                 425                 430         


Ala Leu Asn Ala Lys Ala Tyr Lys Arg Ser Lys Arg Gln Ser Leu Arg 
        435                 440                 445             


Glu Ala Arg Ile Thr Glu Lys Leu Glu Lys Gln Gln Lys Ile Glu Gln 
    450                 455                 460                 


Glu Arg Lys Arg Arg Gln Lys His Gln Glu Tyr Leu Asn Ser Ile Leu 
465                 470                 475                 480 


Gln His Ala Lys Asp Phe Lys Glu Tyr His Arg Ser Val Thr Gly Lys 
                485                 490                 495     


Ile Gln Lys Leu Thr Lys Ala Val Ala Thr Tyr His Ala Asn Thr Glu 
            500                 505                 510         


Arg Glu Gln Lys Lys Glu Asn Glu Arg Ile Glu Lys Glu Arg Met Arg 
        515                 520                 525             


Arg Leu Met Ala Glu Asp Glu Glu Gly Tyr Arg Lys Leu Ile Asp Gln 
    530                 535                 540                 


Lys Lys Asp Lys Arg Leu Ala Tyr Leu Leu Gln Gln Thr Asp Glu Tyr 
545                 550                 555                 560 


Val Ala Asn Leu Thr Glu Leu Val Arg Gln His Lys Ala Ala Gln Val 
                565                 570                 575     


Ala Lys Glu Lys Lys Lys Lys Lys Lys Lys Lys Lys Ala Glu Asn Ala 
            580                 585                 590         


Glu Gly Gln Thr Pro Ala Ile Gly Pro Asp Gly Glu Pro Leu Asp Glu 
        595                 600                 605             


Thr Ser Gln Met Ser Asp Leu Pro Val Lys Val Ile His Val Glu Ser 
    610                 615                 620                 


Gly Lys Ile Leu Thr Gly Thr Asp Ala Pro Lys Ala Gly Gln Leu Glu 
625                 630                 635                 640 


Ala Trp Leu Glu Met Asn Pro Gly Tyr Glu Val Ala Pro Arg Ser Asp 
                645                 650                 655     


Ser Glu Glu Ser Gly Ser Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu 
            660                 665                 670         


Gln Pro Gln Ala Ala Gln Pro Pro Thr Leu Pro Val Glu Glu Lys Lys 
        675                 680                 685             


Lys Ile Pro Asp Pro Asp Ser Asp Asp Val Ser Glu Val Asp Ala Arg 
    690                 695                 700                 


His Ile Ile Glu Asn Ala Lys Gln Asp Val Asp Asp Glu Tyr Gly Val 
705                 710                 715                 720 


Ser Gln Ala Leu Ala Arg Gly Leu Gln Ser Tyr Tyr Ala Val Ala His 
                725                 730                 735     


Ala Val Thr Glu Arg Val Asp Lys Gln Ser Ala Leu Met Val Asn Gly 
            740                 745                 750         


Val Leu Lys Gln Tyr Gln Ile Lys Gly Leu Glu Trp Leu Val Ser Leu 
        755                 760                 765             


Tyr Asn Asn Asn Leu Asn Gly Ile Leu Ala Asp Glu Met Gly Leu Gly 
    770                 775                 780                 


Lys Thr Ile Gln Thr Ile Ala Leu Ile Thr Tyr Leu Met Glu His Lys 
785                 790                 795                 800 


Arg Ile Asn Gly Pro Phe Leu Ile Ile Val Pro Leu Ser Thr Leu Ser 
                805                 810                 815     


Asn Trp Ala Tyr Glu Phe Asp Lys Trp Ala Pro Ser Val Val Lys Val 
            820                 825                 830         


Ser Tyr Lys Gly Ser Pro Ala Ala Arg Arg Ala Phe Val Pro Gln Leu 
        835                 840                 845             


Arg Ser Gly Lys Phe Asn Val Leu Leu Thr Thr Tyr Glu Tyr Ile Ile 
    850                 855                 860                 


Lys Asp Lys His Ile Leu Ala Lys Ile Arg Trp Lys Tyr Met Ile Val 
865                 870                 875                 880 


Asp Glu Gly His Arg Met Lys Asn His His Cys Lys Leu Thr Gln Val 
                885                 890                 895     


Leu Asn Thr His Tyr Val Ala Pro Arg Arg Leu Leu Leu Thr Gly Thr 
            900                 905                 910         


Pro Leu Gln Asn Lys Leu Pro Glu Leu Trp Ala Leu Leu Asn Phe Leu 
        915                 920                 925             


Leu Pro Thr Ile Phe Lys Ser Cys Ser Thr Phe Glu Gln Trp Phe Asn 
    930                 935                 940                 


Ala Pro Phe Ala Met Thr Gly Glu Lys Val Asp Leu Asn Glu Glu Glu 
945                 950                 955                 960 


Thr Ile Leu Ile Ile Arg Arg Leu His Lys Val Leu Arg Pro Phe Leu 
                965                 970                 975     


Leu Arg Arg Leu Lys Lys Glu Val Glu Ala Gln Leu Pro Glu Lys Val 
            980                 985                 990         


Glu Tyr Val Ile Lys Cys Asp Met  Ser Ala Leu Gln Arg  Val Leu Tyr 
        995                 1000                 1005             


Arg His  Met Gln Ala Lys Gly  Val Leu Leu Thr Asp  Gly Ser Glu 
    1010                 1015                 1020             


Lys Asp  Lys Lys Gly Lys Gly  Gly Thr Lys Thr Leu  Met Asn Thr 
    1025                 1030                 1035             


Ile Met  Gln Leu Arg Lys Ile  Cys Asn His Pro Tyr  Met Phe Gln 
    1040                 1045                 1050             


His Ile  Glu Glu Ser Phe Ser  Glu His Leu Gly Phe  Thr Gly Gly 
    1055                 1060                 1065             


Ile Val  Gln Gly Leu Asp Leu  Tyr Arg Ala Ser Gly  Lys Phe Glu 
    1070                 1075                 1080             


Leu Leu  Asp Arg Ile Leu Pro  Lys Leu Arg Ala Thr  Asn His Lys 
    1085                 1090                 1095             


Val Leu  Leu Phe Cys Gln Met  Thr Ser Leu Met Thr  Ile Met Glu 
    1100                 1105                 1110             


Asp Tyr  Phe Ala Tyr Arg Gly  Phe Lys Tyr Leu Arg  Leu Asp Gly 
    1115                 1120                 1125             


Thr Thr  Lys Ala Glu Asp Arg  Gly Met Leu Leu Lys  Thr Phe Asn 
    1130                 1135                 1140             


Glu Pro  Gly Ser Glu Tyr Phe  Ile Phe Leu Leu Ser  Thr Arg Ala 
    1145                 1150                 1155             


Gly Gly  Leu Gly Leu Asn Leu  Gln Ser Ala Asp Thr  Val Ile Ile 
    1160                 1165                 1170             


Phe Asp  Ser Asp Trp Asn Pro  His Gln Asp Leu Gln  Ala Gln Asp 
    1175                 1180                 1185             


Arg Ala  His Arg Ile Gly Gln  Gln Asn Glu Val Arg  Val Leu Arg 
    1190                 1195                 1200             


Leu Cys  Thr Val Asn Ser Val  Glu Glu Lys Ile Leu  Ala Ala Ala 
    1205                 1210                 1215             


Lys Tyr  Lys Leu Asn Val Asp  Gln Lys Val Ile Gln  Ala Gly Met 
    1220                 1225                 1230             


Phe Asp  Gln Lys Ser Ser Ser  His Glu Arg Arg Ala  Phe Leu Gln 
    1235                 1240                 1245             


Ala Ile  Leu Glu His Glu Glu  Gln Asp Glu Glu Glu  Asp Glu Val 
    1250                 1255                 1260             


Pro Asp  Asp Glu Thr Val Asn  Gln Met Ile Ala Arg  His Glu Glu 
    1265                 1270                 1275             


Glu Phe  Asp Leu Phe Met Arg  Met Asp Leu Asp Arg  Arg Arg Glu 
    1280                 1285                 1290             


Glu Ala  Arg Asn Pro Lys Arg  Lys Pro Arg Leu Met  Glu Glu Asp 
    1295                 1300                 1305             


Glu Leu  Pro Ser Trp Ile Ile  Lys Asp Asp Ala Glu  Val Glu Arg 
    1310                 1315                 1320             


Leu Thr  Cys Glu Glu Glu Glu  Glu Lys Met Phe Gly  Arg Gly Ser 
    1325                 1330                 1335             


Arg His  Arg Lys Glu Val Asp  Tyr Ser Asp Ser Leu  Thr Glu Lys 
    1340                 1345                 1350             


Gln Trp  Leu Lys Thr Leu Lys  Ala Ile Glu Glu Gly  Thr Leu Glu 
    1355                 1360                 1365             


Glu Ile  Glu Glu Glu Val Arg  Gln Lys Lys Ser Ser  Arg Lys Arg 
    1370                 1375                 1380             


Lys Arg  Asp Ser Asp Ala Gly  Ser Ser Thr Pro Thr  Thr Ser Thr 
    1385                 1390                 1395             


Arg Ser  Arg Asp Lys Asp Asp  Glu Ser Lys Lys Gln  Lys Lys Arg 
    1400                 1405                 1410             


Gly Arg  Pro Pro Ala Glu Lys  Leu Ser Pro Asn Pro  Pro Asn Leu 
    1415                 1420                 1425             


Thr Lys  Lys Met Lys Lys Ile  Val Asp Ala Val Ile  Lys Tyr Lys 
    1430                 1435                 1440             


Asp Ser  Ser Ser Gly Arg Gln  Leu Ser Glu Val Phe  Ile Gln Leu 
    1445                 1450                 1455             


Pro Ser  Arg Lys Glu Leu Pro  Glu Tyr Tyr Glu Leu  Ile Arg Lys 
    1460                 1465                 1470             


Pro Val  Asp Phe Lys Lys Ile  Lys Glu Arg Ile Arg  Asn His Lys 
    1475                 1480                 1485             


Tyr Arg  Ser Leu Asn Asp Leu  Glu Lys Asp Val Met  Leu Leu Cys 
    1490                 1495                 1500             


Gln Asn  Ala Gln Thr Phe Asn  Leu Glu Gly Ser Leu  Ile Tyr Glu 
    1505                 1510                 1515             


Asp Ser  Ile Val Leu Gln Ser  Val Phe Thr Ser Val  Arg Gln Lys 
    1520                 1525                 1530             


Ile Glu  Lys Glu Asp Asp Ser  Glu Gly Glu Glu Ser  Glu Glu Glu 
    1535                 1540                 1545             


Glu Glu  Gly Glu Glu Glu Gly  Ser Glu Ser Glu Ser  Arg Ser Val 
    1550                 1555                 1560             


Lys Val  Lys Ile Lys Leu Gly  Arg Lys Glu Lys Ala  Gln Asp Arg 
    1565                 1570                 1575             


Leu Lys  Gly Gly Arg Arg Arg  Pro Ser Arg Gly Ser  Arg Ala Lys 
    1580                 1585                 1590             


Pro Val  Val Ser Asp Asp Asp  Ser Glu Glu Glu Gln  Glu Glu Asp 
    1595                 1600                 1605             


Arg Ser  Gly Ser Gly Ser Glu  Glu Asp 
    1610                 1615         


<210> 197
<211> 5329
<212> DNA
<213> Homo sapiens

<400> 197
atgtccactc cagacccacc cctgggcgga actcctcggc caggtccttc cccgggccct       60

ggcccttccc ctggagccat gctgggccct agcccgggtc cctcgccggg ctccgcccac      120

agcatgatgg ggcccagccc agggccgccc tcagcaggac accccatccc cacccagggg      180

cctggagggt accctcagga caacatgcac cagatgcaca agcccatgga gtccatgcat      240

gagaagggca tgtcggacga cccgcgctac aaccagatga aaggaatggg gatgcggtca      300

gggggccatg ctgggatggg gcccccgccc agccccatgg accagcactc ccaaggttac      360

ccctcgcccc tgggtggctc tgagcatgcc tctagtccag ttccagccag tggcccgtct      420

tcggggcccc agatgtcttc cgggccagga ggtgccccgc tggatggtgc tgacccccag      480

gccttggggc agcagaaccg gggcccaacc ccatttaacc agaaccagct gcaccagctc      540

agagctcaga tcatggccta caagatgctg gccagggggc agcccctccc cgaccacctg      600

cagatggcgg tgcagggcaa gcggccgatg cccgggatgc agcagcagat gccaacgcta      660

cctccaccct cggtgtccgc aacaggaccc ggccctggcc ctggccctgg ccccggcccg      720

ggtcccggcc cggcacctcc aaattacagc aggcctcatg gtatgggagg gcccaacatg      780

cctcccccag gaccctcggg cgtgcccccc gggatgccag gccagcctcc tggagggcct      840

cccaagccct ggcctgaagg acccatggcg aatgctgctg cccccacgag cacccctcag      900

aagctgattc ccccgcagcc aacgggccgc ccttcccccg cgccccctgc cgtcccaccc      960

gccgcctcgc ccgtgatgcc accgcagacc cagtcccccg ggcagccggc ccagcccgcg     1020

cccatggtgc cactgcacca gaagcagagc cgcatcaccc ccatccagaa gccgcggggc     1080

ctcgaccctg tggagatcct gcaggagcgc gagtacaggc tgcaggctcg catcgcacac     1140

cgaattcagg aacttgaaaa ccttcccggg tccctggccg gggatttgcg aaccaaagcg     1200

accattgagc tcaaggccct caggctgctg aacttccaga ggcagctgcg ccaggaggtg     1260

gtggtgtgca tgcggaggga cacagcgctg gagacagccc tcaatgctaa ggcctacaag     1320

cgcagcaagc gccagtccct gcgcgaggcc cgcatcactg agaagctgga gaagcagcag     1380

aagatcgagc aggagcgcaa gcgccggcag aagcaccagg aatacctcaa tagcattctc     1440

cagcatgcca aggatttcaa ggaatatcac agatccgtca caggcaaaat ccagaagctg     1500

accaaggcag tggccacgta ccatgccaac acggagcggg agcagaagaa agagaacgag     1560

cggatcgaga aggagcgcat gcggaggctc atggctgaag atgaggaggg gtaccgcaag     1620

ctcatcgacc agaagaagga caagcgcctg gcctacctct tgcagcagac agacgagtac     1680

gtggctaacc tcacggagct ggtgcggcag cacaaggctg cccaggtcgc caaggagaaa     1740

aagaagaaaa agaaaaagaa gaaggcagaa aatgcagaag gacagacgcc tgccattggg     1800

ccggatggcg agcctctgga cgagaccagc cagatgagcg acctcccggt gaaggtgatc     1860

cacgtggaga gtgggaagat cctcacaggc acagatgccc ccaaagccgg gcagctggag     1920

gcctggctcg agatgaaccc ggggtatgaa gtagctccga ggtctgatag tgaagaaagt     1980

ggctcagaag aagaggaaga ggaggaggag gaagagcagc cgcaggcagc acagcctccc     2040

accctgcccg tggaggagaa gaagaagatt ccagatccag acagcgatga cgtctctgag     2100

gtggacgcgc ggcacatcat tgagaatgcc aagcaagatg tcgatgatga atatggcgtg     2160

tcccaggccc ttgcacgtgg cctgcagtcc tactatgccg tggcccatgc tgtcactgag     2220

agagtggaca agcagtcagc gcttatggtc aatggtgtcc tcaaacagta ccagatcaaa     2280

ggtttggagt ggctggtgtc cctgtacaac aacaacctga acggcatcct ggccgacgag     2340

atgggcctgg ggaagaccat ccagaccatc gcgctcatca cgtacctcat ggagcacaaa     2400

cgcatcaatg ggcccttcct catcatcgtg cctctctcaa cgctgtccaa ctgggcgtac     2460

gagtttgaca agtgggcccc ctccgtggtg aaggtgtctt acaagggatc cccagcagca     2520

agacgggcct ttgtccccca gctccggagt gggaagttca acgtcttgct gacgacgtac     2580

gagtacatca tcaaagacaa gcacatcctc gccaagatcc gttggaagta catgattgtg     2640

gacgaaggtc accgcatgaa gaaccaccac tgcaagctga cgcaggtgct caacacgcac     2700

tatgtggcac cccgccgcct gctgctgacg ggcacaccgc tgcagaacaa gcttcccgag     2760

ctctgggcgc tgctcaactt cctgctgccc accatcttca agagctgcag caccttcgag     2820

cagtggttta acgcaccctt tgccatgacc ggggaaaagg tggacctgaa tgaggaggaa     2880

accattctca tcatccggcg tctccacaaa gtgctgcggc ccttcttgct ccgacgactc     2940

aagaaggaag tcgaggccca gttgcccgaa aaggtggagt acgtcatcaa gtgcgacatg     3000

tctgcgctgc agcgagtgct ctaccgccac atgcaggcca agggcgtgct gctgactgat     3060

ggctccgaga aggacaagaa gggcaaaggc ggcaccaaga ccctgatgaa caccatcatg     3120

cagctgcgga agatctgcaa ccacccctac atgttccagc acatcgagga gtccttttcc     3180

gagcacttgg ggttcactgg cggcattgtc caagggctgg acctgtaccg agcctcgggt     3240

aaatttgagc ttcttgatag aattcttccc aaactccgag caaccaacca caaagtgctg     3300

ctgttctgcc aaatgacctc cctcatgacc atcatggaag attactttgc gtatcgcggc     3360

tttaaatacc tcaggcttga tggaaccacg aaggcggagg accggggcat gctgctgaaa     3420

accttcaacg agcccggctc tgagtacttc atcttcctgc tcagcacccg ggctgggggg     3480

ctcggcctga acctccagtc ggcagacact gtgatcattt ttgacagcga ctggaatcct     3540

caccaggacc tgcaagcgca ggaccgagcc caccgcatcg ggcagcagaa cgaggtgcgt     3600

gtgctccgcc tctgcaccgt caacagcgtg gaggagaaga tcctagctgc agccaagtac     3660

aagctcaacg tggaccagaa ggtgatccag gccggcatgt tcgaccagaa gtcctccagc     3720

catgagcggc gcgccttcct gcaggccatc ctggagcacg aggagcagga tgaggaggaa     3780

gacgaggtgc ccgacgacga gaccgtcaac cagatgatcg cccggcacga ggaggagttt     3840

gatctgttca tgcgcatgga cctggaccgc aggcgcgagg aggcccgcaa ccccaagcgg     3900

aagccgcgcc tcatggagga ggacgagctc ccctcgtgga tcatcaagga cgacgcggag     3960

gtggagcggc tgacctgtga ggaggaggag gagaagatgt tcggccgtgg ctcccgccac     4020

cgcaaggagg tggactacag cgactcactg acggagaagc agtggctcaa gaccctgaag     4080

gccatcgagg agggcacgct ggaggagatc gaagaggagg tccggcagaa gaaatcatca     4140

cggaagcgca agcgagacag cgacgccggc tcctccaccc cgaccaccag cacccgcagc     4200

cgcgacaagg acgacgagag caagaagcag aagaagcgcg ggcggccgcc tgccgagaaa     4260

ctctccccta acccacccaa cctcaccaag aagatgaaga agattgtgga tgccgtgatc     4320

aagtacaagg acagcagcag tggacgtcag ctcagcgagg tcttcatcca gctgccctcg     4380

cgaaaggagc tgcccgagta ctacgagctc atccgcaagc ccgtggactt caagaagata     4440

aaggagcgca ttcgcaacca caagtaccgc agcctcaacg acctagagaa ggacgtcatg     4500

ctcctgtgcc agaacgcaca gaccttcaac ctggagggct ccctgatcta tgaagactcc     4560

atcgtcttgc agtcggtctt caccagcgtg cggcagaaaa tcgagaagga ggatgacagt     4620

gaaggcgagg agagtgagga ggaggaagag ggcgaggagg aaggctccga atccgaatct     4680

cggtccgtca aagtgaagat caagcttggc cggaaggaga aggcacagga ccggctgaag     4740

ggcggccggc ggcggccgag ccgagggtcc cgagccaagc cggtcgtgag tgacgatgac     4800

agtgaggagg aacaagagga ggaccgctca ggaagtggca gcgaagaaga ctgagccccg     4860

acattccagt ctcgaccccg agcccctcgt tccagagctg agatggcata ggccttagca     4920

gtaacgggta gcagcagatg tagtttcaga cttggagtaa aactgtataa acaaaagaat     4980

cttccatatt tatacagcag agaagctgta ggactgtttg tgactggccc tgtcctggca     5040

tcagtagcat ctgtaacagc attaactgtc ttaaagagag agagagagaa ttccgaattg     5100

gggaacacac gatacctgtt tttcttttcc gttgctggca gtactgttgc gccgcagttt     5160

ggagtcactg tagttaagtg tggatgcatg tgcgtcaccg tccactcctc ctactgtatt     5220

ttattggaca ggtcagactc gccgggggcc cggcgagggt atgtcagtgt cactggatgt     5280

caaacagtaa taaattaaac caacaacaaa acgcacagcc aaaaaaaaa                 5329


<210> 198
<211> 1616
<212> PRT
<213> Homo sapiens

<400> 198
Met Ser Thr Pro Asp Pro Pro Leu Gly Gly Thr Pro Arg Pro Gly Pro 
1               5                   10                  15      


Ser Pro Gly Pro Gly Pro Ser Pro Gly Ala Met Leu Gly Pro Ser Pro 
            20                  25                  30          


Gly Pro Ser Pro Gly Ser Ala His Ser Met Met Gly Pro Ser Pro Gly 
        35                  40                  45              


Pro Pro Ser Ala Gly His Pro Ile Pro Thr Gln Gly Pro Gly Gly Tyr 
    50                  55                  60                  


Pro Gln Asp Asn Met His Gln Met His Lys Pro Met Glu Ser Met His 
65                  70                  75                  80  


Glu Lys Gly Met Ser Asp Asp Pro Arg Tyr Asn Gln Met Lys Gly Met 
                85                  90                  95      


Gly Met Arg Ser Gly Gly His Ala Gly Met Gly Pro Pro Pro Ser Pro 
            100                 105                 110         


Met Asp Gln His Ser Gln Gly Tyr Pro Ser Pro Leu Gly Gly Ser Glu 
        115                 120                 125             


His Ala Ser Ser Pro Val Pro Ala Ser Gly Pro Ser Ser Gly Pro Gln 
    130                 135                 140                 


Met Ser Ser Gly Pro Gly Gly Ala Pro Leu Asp Gly Ala Asp Pro Gln 
145                 150                 155                 160 


Ala Leu Gly Gln Gln Asn Arg Gly Pro Thr Pro Phe Asn Gln Asn Gln 
                165                 170                 175     


Leu His Gln Leu Arg Ala Gln Ile Met Ala Tyr Lys Met Leu Ala Arg 
            180                 185                 190         


Gly Gln Pro Leu Pro Asp His Leu Gln Met Ala Val Gln Gly Lys Arg 
        195                 200                 205             


Pro Met Pro Gly Met Gln Gln Gln Met Pro Thr Leu Pro Pro Pro Ser 
    210                 215                 220                 


Val Ser Ala Thr Gly Pro Gly Pro Gly Pro Gly Pro Gly Pro Gly Pro 
225                 230                 235                 240 


Gly Pro Gly Pro Ala Pro Pro Asn Tyr Ser Arg Pro His Gly Met Gly 
                245                 250                 255     


Gly Pro Asn Met Pro Pro Pro Gly Pro Ser Gly Val Pro Pro Gly Met 
            260                 265                 270         


Pro Gly Gln Pro Pro Gly Gly Pro Pro Lys Pro Trp Pro Glu Gly Pro 
        275                 280                 285             


Met Ala Asn Ala Ala Ala Pro Thr Ser Thr Pro Gln Lys Leu Ile Pro 
    290                 295                 300                 


Pro Gln Pro Thr Gly Arg Pro Ser Pro Ala Pro Pro Ala Val Pro Pro 
305                 310                 315                 320 


Ala Ala Ser Pro Val Met Pro Pro Gln Thr Gln Ser Pro Gly Gln Pro 
                325                 330                 335     


Ala Gln Pro Ala Pro Met Val Pro Leu His Gln Lys Gln Ser Arg Ile 
            340                 345                 350         


Thr Pro Ile Gln Lys Pro Arg Gly Leu Asp Pro Val Glu Ile Leu Gln 
        355                 360                 365             


Glu Arg Glu Tyr Arg Leu Gln Ala Arg Ile Ala His Arg Ile Gln Glu 
    370                 375                 380                 


Leu Glu Asn Leu Pro Gly Ser Leu Ala Gly Asp Leu Arg Thr Lys Ala 
385                 390                 395                 400 


Thr Ile Glu Leu Lys Ala Leu Arg Leu Leu Asn Phe Gln Arg Gln Leu 
                405                 410                 415     


Arg Gln Glu Val Val Val Cys Met Arg Arg Asp Thr Ala Leu Glu Thr 
            420                 425                 430         


Ala Leu Asn Ala Lys Ala Tyr Lys Arg Ser Lys Arg Gln Ser Leu Arg 
        435                 440                 445             


Glu Ala Arg Ile Thr Glu Lys Leu Glu Lys Gln Gln Lys Ile Glu Gln 
    450                 455                 460                 


Glu Arg Lys Arg Arg Gln Lys His Gln Glu Tyr Leu Asn Ser Ile Leu 
465                 470                 475                 480 


Gln His Ala Lys Asp Phe Lys Glu Tyr His Arg Ser Val Thr Gly Lys 
                485                 490                 495     


Ile Gln Lys Leu Thr Lys Ala Val Ala Thr Tyr His Ala Asn Thr Glu 
            500                 505                 510         


Arg Glu Gln Lys Lys Glu Asn Glu Arg Ile Glu Lys Glu Arg Met Arg 
        515                 520                 525             


Arg Leu Met Ala Glu Asp Glu Glu Gly Tyr Arg Lys Leu Ile Asp Gln 
    530                 535                 540                 


Lys Lys Asp Lys Arg Leu Ala Tyr Leu Leu Gln Gln Thr Asp Glu Tyr 
545                 550                 555                 560 


Val Ala Asn Leu Thr Glu Leu Val Arg Gln His Lys Ala Ala Gln Val 
                565                 570                 575     


Ala Lys Glu Lys Lys Lys Lys Lys Lys Lys Lys Lys Ala Glu Asn Ala 
            580                 585                 590         


Glu Gly Gln Thr Pro Ala Ile Gly Pro Asp Gly Glu Pro Leu Asp Glu 
        595                 600                 605             


Thr Ser Gln Met Ser Asp Leu Pro Val Lys Val Ile His Val Glu Ser 
    610                 615                 620                 


Gly Lys Ile Leu Thr Gly Thr Asp Ala Pro Lys Ala Gly Gln Leu Glu 
625                 630                 635                 640 


Ala Trp Leu Glu Met Asn Pro Gly Tyr Glu Val Ala Pro Arg Ser Asp 
                645                 650                 655     


Ser Glu Glu Ser Gly Ser Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu 
            660                 665                 670         


Gln Pro Gln Ala Ala Gln Pro Pro Thr Leu Pro Val Glu Glu Lys Lys 
        675                 680                 685             


Lys Ile Pro Asp Pro Asp Ser Asp Asp Val Ser Glu Val Asp Ala Arg 
    690                 695                 700                 


His Ile Ile Glu Asn Ala Lys Gln Asp Val Asp Asp Glu Tyr Gly Val 
705                 710                 715                 720 


Ser Gln Ala Leu Ala Arg Gly Leu Gln Ser Tyr Tyr Ala Val Ala His 
                725                 730                 735     


Ala Val Thr Glu Arg Val Asp Lys Gln Ser Ala Leu Met Val Asn Gly 
            740                 745                 750         


Val Leu Lys Gln Tyr Gln Ile Lys Gly Leu Glu Trp Leu Val Ser Leu 
        755                 760                 765             


Tyr Asn Asn Asn Leu Asn Gly Ile Leu Ala Asp Glu Met Gly Leu Gly 
    770                 775                 780                 


Lys Thr Ile Gln Thr Ile Ala Leu Ile Thr Tyr Leu Met Glu His Lys 
785                 790                 795                 800 


Arg Ile Asn Gly Pro Phe Leu Ile Ile Val Pro Leu Ser Thr Leu Ser 
                805                 810                 815     


Asn Trp Ala Tyr Glu Phe Asp Lys Trp Ala Pro Ser Val Val Lys Val 
            820                 825                 830         


Ser Tyr Lys Gly Ser Pro Ala Ala Arg Arg Ala Phe Val Pro Gln Leu 
        835                 840                 845             


Arg Ser Gly Lys Phe Asn Val Leu Leu Thr Thr Tyr Glu Tyr Ile Ile 
    850                 855                 860                 


Lys Asp Lys His Ile Leu Ala Lys Ile Arg Trp Lys Tyr Met Ile Val 
865                 870                 875                 880 


Asp Glu Gly His Arg Met Lys Asn His His Cys Lys Leu Thr Gln Val 
                885                 890                 895     


Leu Asn Thr His Tyr Val Ala Pro Arg Arg Leu Leu Leu Thr Gly Thr 
            900                 905                 910         


Pro Leu Gln Asn Lys Leu Pro Glu Leu Trp Ala Leu Leu Asn Phe Leu 
        915                 920                 925             


Leu Pro Thr Ile Phe Lys Ser Cys Ser Thr Phe Glu Gln Trp Phe Asn 
    930                 935                 940                 


Ala Pro Phe Ala Met Thr Gly Glu Lys Val Asp Leu Asn Glu Glu Glu 
945                 950                 955                 960 


Thr Ile Leu Ile Ile Arg Arg Leu His Lys Val Leu Arg Pro Phe Leu 
                965                 970                 975     


Leu Arg Arg Leu Lys Lys Glu Val Glu Ala Gln Leu Pro Glu Lys Val 
            980                 985                 990         


Glu Tyr Val Ile Lys Cys Asp Met  Ser Ala Leu Gln Arg  Val Leu Tyr 
        995                 1000                 1005             


Arg His  Met Gln Ala Lys Gly  Val Leu Leu Thr Asp  Gly Ser Glu 
    1010                 1015                 1020             


Lys Asp  Lys Lys Gly Lys Gly  Gly Thr Lys Thr Leu  Met Asn Thr 
    1025                 1030                 1035             


Ile Met  Gln Leu Arg Lys Ile  Cys Asn His Pro Tyr  Met Phe Gln 
    1040                 1045                 1050             


His Ile  Glu Glu Ser Phe Ser  Glu His Leu Gly Phe  Thr Gly Gly 
    1055                 1060                 1065             


Ile Val  Gln Gly Leu Asp Leu  Tyr Arg Ala Ser Gly  Lys Phe Glu 
    1070                 1075                 1080             


Leu Leu  Asp Arg Ile Leu Pro  Lys Leu Arg Ala Thr  Asn His Lys 
    1085                 1090                 1095             


Val Leu  Leu Phe Cys Gln Met  Thr Ser Leu Met Thr  Ile Met Glu 
    1100                 1105                 1110             


Asp Tyr  Phe Ala Tyr Arg Gly  Phe Lys Tyr Leu Arg  Leu Asp Gly 
    1115                 1120                 1125             


Thr Thr  Lys Ala Glu Asp Arg  Gly Met Leu Leu Lys  Thr Phe Asn 
    1130                 1135                 1140             


Glu Pro  Gly Ser Glu Tyr Phe  Ile Phe Leu Leu Ser  Thr Arg Ala 
    1145                 1150                 1155             


Gly Gly  Leu Gly Leu Asn Leu  Gln Ser Ala Asp Thr  Val Ile Ile 
    1160                 1165                 1170             


Phe Asp  Ser Asp Trp Asn Pro  His Gln Asp Leu Gln  Ala Gln Asp 
    1175                 1180                 1185             


Arg Ala  His Arg Ile Gly Gln  Gln Asn Glu Val Arg  Val Leu Arg 
    1190                 1195                 1200             


Leu Cys  Thr Val Asn Ser Val  Glu Glu Lys Ile Leu  Ala Ala Ala 
    1205                 1210                 1215             


Lys Tyr  Lys Leu Asn Val Asp  Gln Lys Val Ile Gln  Ala Gly Met 
    1220                 1225                 1230             


Phe Asp  Gln Lys Ser Ser Ser  His Glu Arg Arg Ala  Phe Leu Gln 
    1235                 1240                 1245             


Ala Ile  Leu Glu His Glu Glu  Gln Asp Glu Glu Glu  Asp Glu Val 
    1250                 1255                 1260             


Pro Asp  Asp Glu Thr Val Asn  Gln Met Ile Ala Arg  His Glu Glu 
    1265                 1270                 1275             


Glu Phe  Asp Leu Phe Met Arg  Met Asp Leu Asp Arg  Arg Arg Glu 
    1280                 1285                 1290             


Glu Ala  Arg Asn Pro Lys Arg  Lys Pro Arg Leu Met  Glu Glu Asp 
    1295                 1300                 1305             


Glu Leu  Pro Ser Trp Ile Ile  Lys Asp Asp Ala Glu  Val Glu Arg 
    1310                 1315                 1320             


Leu Thr  Cys Glu Glu Glu Glu  Glu Lys Met Phe Gly  Arg Gly Ser 
    1325                 1330                 1335             


Arg His  Arg Lys Glu Val Asp  Tyr Ser Asp Ser Leu  Thr Glu Lys 
    1340                 1345                 1350             


Gln Trp  Leu Lys Thr Leu Lys  Ala Ile Glu Glu Gly  Thr Leu Glu 
    1355                 1360                 1365             


Glu Ile  Glu Glu Glu Val Arg  Gln Lys Lys Ser Ser  Arg Lys Arg 
    1370                 1375                 1380             


Lys Arg  Asp Ser Asp Ala Gly  Ser Ser Thr Pro Thr  Thr Ser Thr 
    1385                 1390                 1395             


Arg Ser  Arg Asp Lys Asp Asp  Glu Ser Lys Lys Gln  Lys Lys Arg 
    1400                 1405                 1410             


Gly Arg  Pro Pro Ala Glu Lys  Leu Ser Pro Asn Pro  Pro Asn Leu 
    1415                 1420                 1425             


Thr Lys  Lys Met Lys Lys Ile  Val Asp Ala Val Ile  Lys Tyr Lys 
    1430                 1435                 1440             


Asp Ser  Ser Gly Arg Gln Leu  Ser Glu Val Phe Ile  Gln Leu Pro 
    1445                 1450                 1455             


Ser Arg  Lys Glu Leu Pro Glu  Tyr Tyr Glu Leu Ile  Arg Lys Pro 
    1460                 1465                 1470             


Val Asp  Phe Lys Lys Ile Lys  Glu Arg Ile Arg Asn  His Lys Tyr 
    1475                 1480                 1485             


Arg Ser  Leu Asn Asp Leu Glu  Lys Asp Val Met Leu  Leu Cys Gln 
    1490                 1495                 1500             


Asn Ala  Gln Thr Phe Asn Leu  Glu Gly Ser Leu Ile  Tyr Glu Asp 
    1505                 1510                 1515             


Ser Ile  Val Leu Gln Ser Val  Phe Thr Ser Val Arg  Gln Lys Ile 
    1520                 1525                 1530             


Glu Lys  Glu Asp Asp Ser Glu  Gly Glu Glu Ser Glu  Glu Glu Glu 
    1535                 1540                 1545             


Glu Gly  Glu Glu Glu Gly Ser  Glu Ser Glu Ser Arg  Ser Val Lys 
    1550                 1555                 1560             


Val Lys  Ile Lys Leu Gly Arg  Lys Glu Lys Ala Gln  Asp Arg Leu 
    1565                 1570                 1575             


Lys Gly  Gly Arg Arg Arg Pro  Ser Arg Gly Ser Arg  Ala Lys Pro 
    1580                 1585                 1590             


Val Val  Ser Asp Asp Asp Ser  Glu Glu Glu Gln Glu  Glu Asp Arg 
    1595                 1600                 1605             


Ser Gly  Ser Gly Ser Glu Glu  Asp 
    1610                 1615     


<210> 199
<211> 5326
<212> DNA
<213> Homo sapiens

<400> 199
atgtccactc cagacccacc cctgggcgga actcctcggc caggtccttc cccgggccct       60

ggcccttccc ctggagccat gctgggccct agcccgggtc cctcgccggg ctccgcccac      120

agcatgatgg ggcccagccc agggccgccc tcagcaggac accccatccc cacccagggg      180

cctggagggt accctcagga caacatgcac cagatgcaca agcccatgga gtccatgcat      240

gagaagggca tgtcggacga cccgcgctac aaccagatga aaggaatggg gatgcggtca      300

gggggccatg ctgggatggg gcccccgccc agccccatgg accagcactc ccaaggttac      360

ccctcgcccc tgggtggctc tgagcatgcc tctagtccag ttccagccag tggcccgtct      420

tcggggcccc agatgtcttc cgggccagga ggtgccccgc tggatggtgc tgacccccag      480

gccttggggc agcagaaccg gggcccaacc ccatttaacc agaaccagct gcaccagctc      540

agagctcaga tcatggccta caagatgctg gccagggggc agcccctccc cgaccacctg      600

cagatggcgg tgcagggcaa gcggccgatg cccgggatgc agcagcagat gccaacgcta      660

cctccaccct cggtgtccgc aacaggaccc ggccctggcc ctggccctgg ccccggcccg      720

ggtcccggcc cggcacctcc aaattacagc aggcctcatg gtatgggagg gcccaacatg      780

cctcccccag gaccctcggg cgtgcccccc gggatgccag gccagcctcc tggagggcct      840

cccaagccct ggcctgaagg acccatggcg aatgctgctg cccccacgag cacccctcag      900

aagctgattc ccccgcagcc aacgggccgc ccttcccccg cgccccctgc cgtcccaccc      960

gccgcctcgc ccgtgatgcc accgcagacc cagtcccccg ggcagccggc ccagcccgcg     1020

cccatggtgc cactgcacca gaagcagagc cgcatcaccc ccatccagaa gccgcggggc     1080

ctcgaccctg tggagatcct gcaggagcgc gagtacaggc tgcaggctcg catcgcacac     1140

cgaattcagg aacttgaaaa ccttcccggg tccctggccg gggatttgcg aaccaaagcg     1200

accattgagc tcaaggccct caggctgctg aacttccaga ggcagctgcg ccaggaggtg     1260

gtggtgtgca tgcggaggga cacagcgctg gagacagccc tcaatgctaa ggcctacaag     1320

cgcagcaagc gccagtccct gcgcgaggcc cgcatcactg agaagctgga gaagcagcag     1380

aagatcgagc aggagcgcaa gcgccggcag aagcaccagg aatacctcaa tagcattctc     1440

cagcatgcca aggatttcaa ggaatatcac agatccgtca caggcaaaat ccagaagctg     1500

accaaggcag tggccacgta ccatgccaac acggagcggg agcagaagaa agagaacgag     1560

cggatcgaga aggagcgcat gcggaggctc atggctgaag atgaggaggg gtaccgcaag     1620

ctcatcgacc agaagaagga caagcgcctg gcctacctct tgcagcagac agacgagtac     1680

gtggctaacc tcacggagct ggtgcggcag cacaaggctg cccaggtcgc caaggagaaa     1740

aagaagaaaa agaaaaagaa gaaggcagaa aatgcagaag gacagacgcc tgccattggg     1800

ccggatggcg agcctctgga cgagaccagc cagatgagcg acctcccggt gaaggtgatc     1860

cacgtggaga gtgggaagat cctcacaggc acagatgccc ccaaagccgg gcagctggag     1920

gcctggctcg agatgaaccc ggggtatgaa gtagctccga ggtctgatag tgaagaaagt     1980

ggctcagaag aagaggaaga ggaggaggag gaagagcagc cgcaggcagc acagcctccc     2040

accctgcccg tggaggagaa gaagaagatt ccagatccag acagcgatga cgtctctgag     2100

gtggacgcgc ggcacatcat tgagaatgcc aagcaagatg tcgatgatga atatggcgtg     2160

tcccaggccc ttgcacgtgg cctgcagtcc tactatgccg tggcccatgc tgtcactgag     2220

agagtggaca agcagtcagc gcttatggtc aatggtgtcc tcaaacagta ccagatcaaa     2280

ggtttggagt ggctggtgtc cctgtacaac aacaacctga acggcatcct ggccgacgag     2340

atgggcctgg ggaagaccat ccagaccatc gcgctcatca cgtacctcat ggagcacaaa     2400

cgcatcaatg ggcccttcct catcatcgtg cctctctcaa cgctgtccaa ctgggcgtac     2460

gagtttgaca agtgggcccc ctccgtggtg aaggtgtctt acaagggatc cccagcagca     2520

agacgggcct ttgtccccca gctccggagt gggaagttca acgtcttgct gacgacgtac     2580

gagtacatca tcaaagacaa gcacatcctc gccaagatcc gttggaagta catgattgtg     2640

gacgaaggtc accgcatgaa gaaccaccac tgcaagctga cgcaggtgct caacacgcac     2700

tatgtggcac cccgccgcct gctgctgacg ggcacaccgc tgcagaacaa gcttcccgag     2760

ctctgggcgc tgctcaactt cctgctgccc accatcttca agagctgcag caccttcgag     2820

cagtggttta acgcaccctt tgccatgacc ggggaaaagg tggacctgaa tgaggaggaa     2880

accattctca tcatccggcg tctccacaaa gtgctgcggc ccttcttgct ccgacgactc     2940

aagaaggaag tcgaggccca gttgcccgaa aaggtggagt acgtcatcaa gtgcgacatg     3000

tctgcgctgc agcgagtgct ctaccgccac atgcaggcca agggcgtgct gctgactgat     3060

ggctccgaga aggacaagaa gggcaaaggc ggcaccaaga ccctgatgaa caccatcatg     3120

cagctgcgga agatctgcaa ccacccctac atgttccagc acatcgagga gtccttttcc     3180

gagcacttgg ggttcactgg cggcattgtc caagggctgg acctgtaccg agcctcgggt     3240

aaatttgagc ttcttgatag aattcttccc aaactccgag caaccaacca caaagtgctg     3300

ctgttctgcc aaatgacctc cctcatgacc atcatggaag attactttgc gtatcgcggc     3360

tttaaatacc tcaggcttga tggaaccacg aaggcggagg accggggcat gctgctgaaa     3420

accttcaacg agcccggctc tgagtacttc atcttcctgc tcagcacccg ggctgggggg     3480

ctcggcctga acctccagtc ggcagacact gtgatcattt ttgacagcga ctggaatcct     3540

caccaggacc tgcaagcgca ggaccgagcc caccgcatcg ggcagcagaa cgaggtgcgt     3600

gtgctccgcc tctgcaccgt caacagcgtg gaggagaaga tcctagctgc agccaagtac     3660

aagctcaacg tggaccagaa ggtgatccag gccggcatgt tcgaccagaa gtcctccagc     3720

catgagcggc gcgccttcct gcaggccatc ctggagcacg aggagcagga tgaggaggaa     3780

gacgaggtgc ccgacgacga gaccgtcaac cagatgatcg cccggcacga ggaggagttt     3840

gatctgttca tgcgcatgga cctggaccgc aggcgcgagg aggcccgcaa ccccaagcgg     3900

aagccgcgcc tcatggagga ggacgagctc ccctcgtgga tcatcaagga cgacgcggag     3960

gtggagcggc tgacctgtga ggaggaggag gagaagatgt tcggccgtgg ctcccgccac     4020

cgcaaggagg tggactacag cgactcactg acggagaagc agtggctcaa gaccctgaag     4080

gccatcgagg agggcacgct ggaggagatc gaagaggagg tccggcagaa gaaatcatca     4140

cggaagcgca agcgagacag cgacgccggc tcctccaccc cgaccaccag cacccgcagc     4200

cgcgacaagg acgacgagag caagaagcag aagaagcgcg ggcggccgcc tgccgagaaa     4260

ctctccccta acccacccaa cctcaccaag aagatgaaga agattgtgga tgccgtgatc     4320

aagtacaagg acagcagtgg acgtcagctc agcgaggtct tcatccagct gccctcgcga     4380

aaggagctgc ccgagtacta cgagctcatc cgcaagcccg tggacttcaa gaagataaag     4440

gagcgcattc gcaaccacaa gtaccgcagc ctcaacgacc tagagaagga cgtcatgctc     4500

ctgtgccaga acgcacagac cttcaacctg gagggctccc tgatctatga agactccatc     4560

gtcttgcagt cggtcttcac cagcgtgcgg cagaaaatcg agaaggagga tgacagtgaa     4620

ggcgaggaga gtgaggagga ggaagagggc gaggaggaag gctccgaatc cgaatctcgg     4680

tccgtcaaag tgaagatcaa gcttggccgg aaggagaagg cacaggaccg gctgaagggc     4740

ggccggcggc ggccgagccg agggtcccga gccaagccgg tcgtgagtga cgatgacagt     4800

gaggaggaac aagaggagga ccgctcagga agtggcagcg aagaagactg agccccgaca     4860

ttccagtctc gaccccgagc ccctcgttcc agagctgaga tggcataggc cttagcagta     4920

acgggtagca gcagatgtag tttcagactt ggagtaaaac tgtataaaca aaagaatctt     4980

ccatatttat acagcagaga agctgtagga ctgtttgtga ctggccctgt cctggcatca     5040

gtagcatctg taacagcatt aactgtctta aagagagaga gagagaattc cgaattgggg     5100

aacacacgat acctgttttt cttttccgtt gctggcagta ctgttgcgcc gcagtttgga     5160

gtcactgtag ttaagtgtgg atgcatgtgc gtcaccgtcc actcctccta ctgtatttta     5220

ttggacaggt cagactcgcc gggggcccgg cgagggtatg tcagtgtcac tggatgtcaa     5280

acagtaataa attaaaccaa caacaaaacg cacagccaaa aaaaaa                    5326


<210> 200
<211> 1614
<212> PRT
<213> Homo sapiens

<400> 200
Met Ser Thr Pro Asp Pro Pro Leu Gly Gly Thr Pro Arg Pro Gly Pro 
1               5                   10                  15      


Ser Pro Gly Pro Gly Pro Ser Pro Gly Ala Met Leu Gly Pro Ser Pro 
            20                  25                  30          


Gly Pro Ser Pro Gly Ser Ala His Ser Met Met Gly Pro Ser Pro Gly 
        35                  40                  45              


Pro Pro Ser Ala Gly His Pro Ile Pro Thr Gln Gly Pro Gly Gly Tyr 
    50                  55                  60                  


Pro Gln Asp Asn Met His Gln Met His Lys Pro Met Glu Ser Met His 
65                  70                  75                  80  


Glu Lys Gly Met Ser Asp Asp Pro Arg Tyr Asn Gln Met Lys Gly Met 
                85                  90                  95      


Gly Met Arg Ser Gly Gly His Ala Gly Met Gly Pro Pro Pro Ser Pro 
            100                 105                 110         


Met Asp Gln His Ser Gln Gly Tyr Pro Ser Pro Leu Gly Gly Ser Glu 
        115                 120                 125             


His Ala Ser Ser Pro Val Pro Ala Ser Gly Pro Ser Ser Gly Pro Gln 
    130                 135                 140                 


Met Ser Ser Gly Pro Gly Gly Ala Pro Leu Asp Gly Ala Asp Pro Gln 
145                 150                 155                 160 


Ala Leu Gly Gln Gln Asn Arg Gly Pro Thr Pro Phe Asn Gln Asn Gln 
                165                 170                 175     


Leu His Gln Leu Arg Ala Gln Ile Met Ala Tyr Lys Met Leu Ala Arg 
            180                 185                 190         


Gly Gln Pro Leu Pro Asp His Leu Gln Met Ala Val Gln Gly Lys Arg 
        195                 200                 205             


Pro Met Pro Gly Met Gln Gln Gln Met Pro Thr Leu Pro Pro Pro Ser 
    210                 215                 220                 


Val Ser Ala Thr Gly Pro Gly Pro Gly Pro Gly Pro Gly Pro Gly Pro 
225                 230                 235                 240 


Gly Pro Gly Pro Ala Pro Pro Asn Tyr Ser Arg Pro His Gly Met Gly 
                245                 250                 255     


Gly Pro Asn Met Pro Pro Pro Gly Pro Ser Gly Val Pro Pro Gly Met 
            260                 265                 270         


Pro Gly Gln Pro Pro Gly Gly Pro Pro Lys Pro Trp Pro Glu Gly Pro 
        275                 280                 285             


Met Ala Asn Ala Ala Ala Pro Thr Ser Thr Pro Gln Lys Leu Ile Pro 
    290                 295                 300                 


Pro Gln Pro Thr Gly Arg Pro Ser Pro Ala Pro Pro Ala Val Pro Pro 
305                 310                 315                 320 


Ala Ala Ser Pro Val Met Pro Pro Gln Thr Gln Ser Pro Gly Gln Pro 
                325                 330                 335     


Ala Gln Pro Ala Pro Met Val Pro Leu His Gln Lys Gln Ser Arg Ile 
            340                 345                 350         


Thr Pro Ile Gln Lys Pro Arg Gly Leu Asp Pro Val Glu Ile Leu Gln 
        355                 360                 365             


Glu Arg Glu Tyr Arg Leu Gln Ala Arg Ile Ala His Arg Ile Gln Glu 
    370                 375                 380                 


Leu Glu Asn Leu Pro Gly Ser Leu Ala Gly Asp Leu Arg Thr Lys Ala 
385                 390                 395                 400 


Thr Ile Glu Leu Lys Ala Leu Arg Leu Leu Asn Phe Gln Arg Gln Leu 
                405                 410                 415     


Arg Gln Glu Val Val Val Cys Met Arg Arg Asp Thr Ala Leu Glu Thr 
            420                 425                 430         


Ala Leu Asn Ala Lys Ala Tyr Lys Arg Ser Lys Arg Gln Ser Leu Arg 
        435                 440                 445             


Glu Ala Arg Ile Thr Glu Lys Leu Glu Lys Gln Gln Lys Ile Glu Gln 
    450                 455                 460                 


Glu Arg Lys Arg Arg Gln Lys His Gln Glu Tyr Leu Asn Ser Ile Leu 
465                 470                 475                 480 


Gln His Ala Lys Asp Phe Lys Glu Tyr His Arg Ser Val Thr Gly Lys 
                485                 490                 495     


Ile Gln Lys Leu Thr Lys Ala Val Ala Thr Tyr His Ala Asn Thr Glu 
            500                 505                 510         


Arg Glu Gln Lys Lys Glu Asn Glu Arg Ile Glu Lys Glu Arg Met Arg 
        515                 520                 525             


Arg Leu Met Ala Glu Asp Glu Glu Gly Tyr Arg Lys Leu Ile Asp Gln 
    530                 535                 540                 


Lys Lys Asp Lys Arg Leu Ala Tyr Leu Leu Gln Gln Thr Asp Glu Tyr 
545                 550                 555                 560 


Val Ala Asn Leu Thr Glu Leu Val Arg Gln His Lys Ala Ala Gln Val 
                565                 570                 575     


Ala Lys Glu Lys Lys Lys Lys Lys Lys Lys Lys Lys Ala Glu Asn Ala 
            580                 585                 590         


Glu Gly Gln Thr Pro Ala Ile Gly Pro Asp Gly Glu Pro Leu Asp Glu 
        595                 600                 605             


Thr Ser Gln Met Ser Asp Leu Pro Val Lys Val Ile His Val Glu Ser 
    610                 615                 620                 


Gly Lys Ile Leu Thr Gly Thr Asp Ala Pro Lys Ala Gly Gln Leu Glu 
625                 630                 635                 640 


Ala Trp Leu Glu Met Asn Pro Gly Tyr Glu Val Ala Pro Arg Ser Asp 
                645                 650                 655     


Ser Glu Glu Ser Gly Ser Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu 
            660                 665                 670         


Gln Pro Gln Ala Ala Gln Pro Pro Thr Leu Pro Val Glu Glu Lys Lys 
        675                 680                 685             


Lys Ile Pro Asp Pro Asp Ser Asp Asp Val Ser Glu Val Asp Ala Arg 
    690                 695                 700                 


His Ile Ile Glu Asn Ala Lys Gln Asp Val Asp Asp Glu Tyr Gly Val 
705                 710                 715                 720 


Ser Gln Ala Leu Ala Arg Gly Leu Gln Ser Tyr Tyr Ala Val Ala His 
                725                 730                 735     


Ala Val Thr Glu Arg Val Asp Lys Gln Ser Ala Leu Met Val Asn Gly 
            740                 745                 750         


Val Leu Lys Gln Tyr Gln Ile Lys Gly Leu Glu Trp Leu Val Ser Leu 
        755                 760                 765             


Tyr Asn Asn Asn Leu Asn Gly Ile Leu Ala Asp Glu Met Gly Leu Gly 
    770                 775                 780                 


Lys Thr Ile Gln Thr Ile Ala Leu Ile Thr Tyr Leu Met Glu His Lys 
785                 790                 795                 800 


Arg Ile Asn Gly Pro Phe Leu Ile Ile Val Pro Leu Ser Thr Leu Ser 
                805                 810                 815     


Asn Trp Ala Tyr Glu Phe Asp Lys Trp Ala Pro Ser Val Val Lys Val 
            820                 825                 830         


Ser Tyr Lys Gly Ser Pro Ala Ala Arg Arg Ala Phe Val Pro Gln Leu 
        835                 840                 845             


Arg Ser Gly Lys Phe Asn Val Leu Leu Thr Thr Tyr Glu Tyr Ile Ile 
    850                 855                 860                 


Lys Asp Lys His Ile Leu Ala Lys Ile Arg Trp Lys Tyr Met Ile Val 
865                 870                 875                 880 


Asp Glu Gly His Arg Met Lys Asn His His Cys Lys Leu Thr Gln Val 
                885                 890                 895     


Leu Asn Thr His Tyr Val Ala Pro Arg Arg Leu Leu Leu Thr Gly Thr 
            900                 905                 910         


Pro Leu Gln Asn Lys Leu Pro Glu Leu Trp Ala Leu Leu Asn Phe Leu 
        915                 920                 925             


Leu Pro Thr Ile Phe Lys Ser Cys Ser Thr Phe Glu Gln Trp Phe Asn 
    930                 935                 940                 


Ala Pro Phe Ala Met Thr Gly Glu Lys Val Asp Leu Asn Glu Glu Glu 
945                 950                 955                 960 


Thr Ile Leu Ile Ile Arg Arg Leu His Lys Val Leu Arg Pro Phe Leu 
                965                 970                 975     


Leu Arg Arg Leu Lys Lys Glu Val Glu Ala Gln Leu Pro Glu Lys Val 
            980                 985                 990         


Glu Tyr Val Ile Lys Cys Asp Met  Ser Ala Leu Gln Arg  Val Leu Tyr 
        995                 1000                 1005             


Arg His  Met Gln Ala Lys Gly  Val Leu Leu Thr Asp  Gly Ser Glu 
    1010                 1015                 1020             


Lys Asp  Lys Lys Gly Lys Gly  Gly Thr Lys Thr Leu  Met Asn Thr 
    1025                 1030                 1035             


Ile Met  Gln Leu Arg Lys Ile  Cys Asn His Pro Tyr  Met Phe Gln 
    1040                 1045                 1050             


His Ile  Glu Glu Ser Phe Ser  Glu His Leu Gly Phe  Thr Gly Gly 
    1055                 1060                 1065             


Ile Val  Gln Gly Leu Asp Leu  Tyr Arg Ala Ser Gly  Lys Phe Glu 
    1070                 1075                 1080             


Leu Leu  Asp Arg Ile Leu Pro  Lys Leu Arg Ala Thr  Asn His Lys 
    1085                 1090                 1095             


Val Leu  Leu Phe Cys Gln Met  Thr Ser Leu Met Thr  Ile Met Glu 
    1100                 1105                 1110             


Asp Tyr  Phe Ala Tyr Arg Gly  Phe Lys Tyr Leu Arg  Leu Asp Gly 
    1115                 1120                 1125             


Thr Thr  Lys Ala Glu Asp Arg  Gly Met Leu Leu Lys  Thr Phe Asn 
    1130                 1135                 1140             


Glu Pro  Gly Ser Glu Tyr Phe  Ile Phe Leu Leu Ser  Thr Arg Ala 
    1145                 1150                 1155             


Gly Gly  Leu Gly Leu Asn Leu  Gln Ser Ala Asp Thr  Val Ile Ile 
    1160                 1165                 1170             


Phe Asp  Ser Asp Trp Asn Pro  His Gln Asp Leu Gln  Ala Gln Asp 
    1175                 1180                 1185             


Arg Ala  His Arg Ile Gly Gln  Gln Asn Glu Val Arg  Val Leu Arg 
    1190                 1195                 1200             


Leu Cys  Thr Val Asn Ser Val  Glu Glu Lys Ile Leu  Ala Ala Ala 
    1205                 1210                 1215             


Lys Tyr  Lys Leu Asn Val Asp  Gln Lys Val Ile Gln  Ala Gly Met 
    1220                 1225                 1230             


Phe Asp  Gln Lys Ser Ser Ser  His Glu Arg Arg Ala  Phe Leu Gln 
    1235                 1240                 1245             


Ala Ile  Leu Glu His Glu Glu  Gln Asp Glu Glu Glu  Asp Glu Val 
    1250                 1255                 1260             


Pro Asp  Asp Glu Thr Val Asn  Gln Met Ile Ala Arg  His Glu Glu 
    1265                 1270                 1275             


Glu Phe  Asp Leu Phe Met Arg  Met Asp Leu Asp Arg  Arg Arg Glu 
    1280                 1285                 1290             


Glu Ala  Arg Asn Pro Lys Arg  Lys Pro Arg Leu Met  Glu Glu Asp 
    1295                 1300                 1305             


Glu Leu  Pro Ser Trp Ile Ile  Lys Asp Asp Ala Glu  Val Glu Arg 
    1310                 1315                 1320             


Leu Thr  Cys Glu Glu Glu Glu  Glu Lys Met Phe Gly  Arg Gly Ser 
    1325                 1330                 1335             


Arg His  Arg Lys Glu Val Asp  Tyr Ser Asp Ser Leu  Thr Glu Lys 
    1340                 1345                 1350             


Gln Trp  Leu Lys Ala Ile Glu  Glu Gly Thr Leu Glu  Glu Ile Glu 
    1355                 1360                 1365             


Glu Glu  Val Arg Gln Lys Lys  Ser Ser Arg Lys Arg  Lys Arg Asp 
    1370                 1375                 1380             


Ser Asp  Ala Gly Ser Ser Thr  Pro Thr Thr Ser Thr  Arg Ser Arg 
    1385                 1390                 1395             


Asp Lys  Asp Asp Glu Ser Lys  Lys Gln Lys Lys Arg  Gly Arg Pro 
    1400                 1405                 1410             


Pro Ala  Glu Lys Leu Ser Pro  Asn Pro Pro Asn Leu  Thr Lys Lys 
    1415                 1420                 1425             


Met Lys  Lys Ile Val Asp Ala  Val Ile Lys Tyr Lys  Asp Ser Ser 
    1430                 1435                 1440             


Ser Gly  Arg Gln Leu Ser Glu  Val Phe Ile Gln Leu  Pro Ser Arg 
    1445                 1450                 1455             


Lys Glu  Leu Pro Glu Tyr Tyr  Glu Leu Ile Arg Lys  Pro Val Asp 
    1460                 1465                 1470             


Phe Lys  Lys Ile Lys Glu Arg  Ile Arg Asn His Lys  Tyr Arg Ser 
    1475                 1480                 1485             


Leu Asn  Asp Leu Glu Lys Asp  Val Met Leu Leu Cys  Gln Asn Ala 
    1490                 1495                 1500             


Gln Thr  Phe Asn Leu Glu Gly  Ser Leu Ile Tyr Glu  Asp Ser Ile 
    1505                 1510                 1515             


Val Leu  Gln Ser Val Phe Thr  Ser Val Arg Gln Lys  Ile Glu Lys 
    1520                 1525                 1530             


Glu Asp  Asp Ser Glu Gly Glu  Glu Ser Glu Glu Glu  Glu Glu Gly 
    1535                 1540                 1545             


Glu Glu  Glu Gly Ser Glu Ser  Glu Ser Arg Ser Val  Lys Val Lys 
    1550                 1555                 1560             


Ile Lys  Leu Gly Arg Lys Glu  Lys Ala Gln Asp Arg  Leu Lys Gly 
    1565                 1570                 1575             


Gly Arg  Arg Arg Pro Ser Arg  Gly Ser Arg Ala Lys  Pro Val Val 
    1580                 1585                 1590             


Ser Asp  Asp Asp Ser Glu Glu  Glu Gln Glu Glu Asp  Arg Ser Gly 
    1595                 1600                 1605             


Ser Gly  Ser Glu Glu Asp 
    1610                 


<210> 201
<211> 5320
<212> DNA
<213> Homo sapiens

<400> 201
atgtccactc cagacccacc cctgggcgga actcctcggc caggtccttc cccgggccct       60

ggcccttccc ctggagccat gctgggccct agcccgggtc cctcgccggg ctccgcccac      120

agcatgatgg ggcccagccc agggccgccc tcagcaggac accccatccc cacccagggg      180

cctggagggt accctcagga caacatgcac cagatgcaca agcccatgga gtccatgcat      240

gagaagggca tgtcggacga cccgcgctac aaccagatga aaggaatggg gatgcggtca      300

gggggccatg ctgggatggg gcccccgccc agccccatgg accagcactc ccaaggttac      360

ccctcgcccc tgggtggctc tgagcatgcc tctagtccag ttccagccag tggcccgtct      420

tcggggcccc agatgtcttc cgggccagga ggtgccccgc tggatggtgc tgacccccag      480

gccttggggc agcagaaccg gggcccaacc ccatttaacc agaaccagct gcaccagctc      540

agagctcaga tcatggccta caagatgctg gccagggggc agcccctccc cgaccacctg      600

cagatggcgg tgcagggcaa gcggccgatg cccgggatgc agcagcagat gccaacgcta      660

cctccaccct cggtgtccgc aacaggaccc ggccctggcc ctggccctgg ccccggcccg      720

ggtcccggcc cggcacctcc aaattacagc aggcctcatg gtatgggagg gcccaacatg      780

cctcccccag gaccctcggg cgtgcccccc gggatgccag gccagcctcc tggagggcct      840

cccaagccct ggcctgaagg acccatggcg aatgctgctg cccccacgag cacccctcag      900

aagctgattc ccccgcagcc aacgggccgc ccttcccccg cgccccctgc cgtcccaccc      960

gccgcctcgc ccgtgatgcc accgcagacc cagtcccccg ggcagccggc ccagcccgcg     1020

cccatggtgc cactgcacca gaagcagagc cgcatcaccc ccatccagaa gccgcggggc     1080

ctcgaccctg tggagatcct gcaggagcgc gagtacaggc tgcaggctcg catcgcacac     1140

cgaattcagg aacttgaaaa ccttcccggg tccctggccg gggatttgcg aaccaaagcg     1200

accattgagc tcaaggccct caggctgctg aacttccaga ggcagctgcg ccaggaggtg     1260

gtggtgtgca tgcggaggga cacagcgctg gagacagccc tcaatgctaa ggcctacaag     1320

cgcagcaagc gccagtccct gcgcgaggcc cgcatcactg agaagctgga gaagcagcag     1380

aagatcgagc aggagcgcaa gcgccggcag aagcaccagg aatacctcaa tagcattctc     1440

cagcatgcca aggatttcaa ggaatatcac agatccgtca caggcaaaat ccagaagctg     1500

accaaggcag tggccacgta ccatgccaac acggagcggg agcagaagaa agagaacgag     1560

cggatcgaga aggagcgcat gcggaggctc atggctgaag atgaggaggg gtaccgcaag     1620

ctcatcgacc agaagaagga caagcgcctg gcctacctct tgcagcagac agacgagtac     1680

gtggctaacc tcacggagct ggtgcggcag cacaaggctg cccaggtcgc caaggagaaa     1740

aagaagaaaa agaaaaagaa gaaggcagaa aatgcagaag gacagacgcc tgccattggg     1800

ccggatggcg agcctctgga cgagaccagc cagatgagcg acctcccggt gaaggtgatc     1860

cacgtggaga gtgggaagat cctcacaggc acagatgccc ccaaagccgg gcagctggag     1920

gcctggctcg agatgaaccc ggggtatgaa gtagctccga ggtctgatag tgaagaaagt     1980

ggctcagaag aagaggaaga ggaggaggag gaagagcagc cgcaggcagc acagcctccc     2040

accctgcccg tggaggagaa gaagaagatt ccagatccag acagcgatga cgtctctgag     2100

gtggacgcgc ggcacatcat tgagaatgcc aagcaagatg tcgatgatga atatggcgtg     2160

tcccaggccc ttgcacgtgg cctgcagtcc tactatgccg tggcccatgc tgtcactgag     2220

agagtggaca agcagtcagc gcttatggtc aatggtgtcc tcaaacagta ccagatcaaa     2280

ggtttggagt ggctggtgtc cctgtacaac aacaacctga acggcatcct ggccgacgag     2340

atgggcctgg ggaagaccat ccagaccatc gcgctcatca cgtacctcat ggagcacaaa     2400

cgcatcaatg ggcccttcct catcatcgtg cctctctcaa cgctgtccaa ctgggcgtac     2460

gagtttgaca agtgggcccc ctccgtggtg aaggtgtctt acaagggatc cccagcagca     2520

agacgggcct ttgtccccca gctccggagt gggaagttca acgtcttgct gacgacgtac     2580

gagtacatca tcaaagacaa gcacatcctc gccaagatcc gttggaagta catgattgtg     2640

gacgaaggtc accgcatgaa gaaccaccac tgcaagctga cgcaggtgct caacacgcac     2700

tatgtggcac cccgccgcct gctgctgacg ggcacaccgc tgcagaacaa gcttcccgag     2760

ctctgggcgc tgctcaactt cctgctgccc accatcttca agagctgcag caccttcgag     2820

cagtggttta acgcaccctt tgccatgacc ggggaaaagg tggacctgaa tgaggaggaa     2880

accattctca tcatccggcg tctccacaaa gtgctgcggc ccttcttgct ccgacgactc     2940

aagaaggaag tcgaggccca gttgcccgaa aaggtggagt acgtcatcaa gtgcgacatg     3000

tctgcgctgc agcgagtgct ctaccgccac atgcaggcca agggcgtgct gctgactgat     3060

ggctccgaga aggacaagaa gggcaaaggc ggcaccaaga ccctgatgaa caccatcatg     3120

cagctgcgga agatctgcaa ccacccctac atgttccagc acatcgagga gtccttttcc     3180

gagcacttgg ggttcactgg cggcattgtc caagggctgg acctgtaccg agcctcgggt     3240

aaatttgagc ttcttgatag aattcttccc aaactccgag caaccaacca caaagtgctg     3300

ctgttctgcc aaatgacctc cctcatgacc atcatggaag attactttgc gtatcgcggc     3360

tttaaatacc tcaggcttga tggaaccacg aaggcggagg accggggcat gctgctgaaa     3420

accttcaacg agcccggctc tgagtacttc atcttcctgc tcagcacccg ggctgggggg     3480

ctcggcctga acctccagtc ggcagacact gtgatcattt ttgacagcga ctggaatcct     3540

caccaggacc tgcaagcgca ggaccgagcc caccgcatcg ggcagcagaa cgaggtgcgt     3600

gtgctccgcc tctgcaccgt caacagcgtg gaggagaaga tcctagctgc agccaagtac     3660

aagctcaacg tggaccagaa ggtgatccag gccggcatgt tcgaccagaa gtcctccagc     3720

catgagcggc gcgccttcct gcaggccatc ctggagcacg aggagcagga tgaggaggaa     3780

gacgaggtgc ccgacgacga gaccgtcaac cagatgatcg cccggcacga ggaggagttt     3840

gatctgttca tgcgcatgga cctggaccgc aggcgcgagg aggcccgcaa ccccaagcgg     3900

aagccgcgcc tcatggagga ggacgagctc ccctcgtgga tcatcaagga cgacgcggag     3960

gtggagcggc tgacctgtga ggaggaggag gagaagatgt tcggccgtgg ctcccgccac     4020

cgcaaggagg tggactacag cgactcactg acggagaagc agtggctcaa ggccatcgag     4080

gagggcacgc tggaggagat cgaagaggag gtccggcaga agaaatcatc acggaagcgc     4140

aagcgagaca gcgacgccgg ctcctccacc ccgaccacca gcacccgcag ccgcgacaag     4200

gacgacgaga gcaagaagca gaagaagcgc gggcggccgc ctgccgagaa actctcccct     4260

aacccaccca acctcaccaa gaagatgaag aagattgtgg atgccgtgat caagtacaag     4320

gacagcagca gtggacgtca gctcagcgag gtcttcatcc agctgccctc gcgaaaggag     4380

ctgcccgagt actacgagct catccgcaag cccgtggact tcaagaagat aaaggagcgc     4440

attcgcaacc acaagtaccg cagcctcaac gacctagaga aggacgtcat gctcctgtgc     4500

cagaacgcac agaccttcaa cctggagggc tccctgatct atgaagactc catcgtcttg     4560

cagtcggtct tcaccagcgt gcggcagaaa atcgagaagg aggatgacag tgaaggcgag     4620

gagagtgagg aggaggaaga gggcgaggag gaaggctccg aatccgaatc tcggtccgtc     4680

aaagtgaaga tcaagcttgg ccggaaggag aaggcacagg accggctgaa gggcggccgg     4740

cggcggccga gccgagggtc ccgagccaag ccggtcgtga gtgacgatga cagtgaggag     4800

gaacaagagg aggaccgctc aggaagtggc agcgaagaag actgagcccc gacattccag     4860

tctcgacccc gagcccctcg ttccagagct gagatggcat aggccttagc agtaacgggt     4920

agcagcagat gtagtttcag acttggagta aaactgtata aacaaaagaa tcttccatat     4980

ttatacagca gagaagctgt aggactgttt gtgactggcc ctgtcctggc atcagtagca     5040

tctgtaacag cattaactgt cttaaagaga gagagagaga attccgaatt ggggaacaca     5100

cgatacctgt ttttcttttc cgttgctggc agtactgttg cgccgcagtt tggagtcact     5160

gtagttaagt gtggatgcat gtgcgtcacc gtccactcct cctactgtat tttattggac     5220

aggtcagact cgccgggggc ccggcgaggg tatgtcagtg tcactggatg tcaaacagta     5280

ataaattaaa ccaacaacaa aacgcacagc caaaaaaaaa                           5320


<210> 202
<211> 1613
<212> PRT
<213> Homo sapiens

<400> 202
Met Ser Thr Pro Asp Pro Pro Leu Gly Gly Thr Pro Arg Pro Gly Pro 
1               5                   10                  15      


Ser Pro Gly Pro Gly Pro Ser Pro Gly Ala Met Leu Gly Pro Ser Pro 
            20                  25                  30          


Gly Pro Ser Pro Gly Ser Ala His Ser Met Met Gly Pro Ser Pro Gly 
        35                  40                  45              


Pro Pro Ser Ala Gly His Pro Ile Pro Thr Gln Gly Pro Gly Gly Tyr 
    50                  55                  60                  


Pro Gln Asp Asn Met His Gln Met His Lys Pro Met Glu Ser Met His 
65                  70                  75                  80  


Glu Lys Gly Met Ser Asp Asp Pro Arg Tyr Asn Gln Met Lys Gly Met 
                85                  90                  95      


Gly Met Arg Ser Gly Gly His Ala Gly Met Gly Pro Pro Pro Ser Pro 
            100                 105                 110         


Met Asp Gln His Ser Gln Gly Tyr Pro Ser Pro Leu Gly Gly Ser Glu 
        115                 120                 125             


His Ala Ser Ser Pro Val Pro Ala Ser Gly Pro Ser Ser Gly Pro Gln 
    130                 135                 140                 


Met Ser Ser Gly Pro Gly Gly Ala Pro Leu Asp Gly Ala Asp Pro Gln 
145                 150                 155                 160 


Ala Leu Gly Gln Gln Asn Arg Gly Pro Thr Pro Phe Asn Gln Asn Gln 
                165                 170                 175     


Leu His Gln Leu Arg Ala Gln Ile Met Ala Tyr Lys Met Leu Ala Arg 
            180                 185                 190         


Gly Gln Pro Leu Pro Asp His Leu Gln Met Ala Val Gln Gly Lys Arg 
        195                 200                 205             


Pro Met Pro Gly Met Gln Gln Gln Met Pro Thr Leu Pro Pro Pro Ser 
    210                 215                 220                 


Val Ser Ala Thr Gly Pro Gly Pro Gly Pro Gly Pro Gly Pro Gly Pro 
225                 230                 235                 240 


Gly Pro Gly Pro Ala Pro Pro Asn Tyr Ser Arg Pro His Gly Met Gly 
                245                 250                 255     


Gly Pro Asn Met Pro Pro Pro Gly Pro Ser Gly Val Pro Pro Gly Met 
            260                 265                 270         


Pro Gly Gln Pro Pro Gly Gly Pro Pro Lys Pro Trp Pro Glu Gly Pro 
        275                 280                 285             


Met Ala Asn Ala Ala Ala Pro Thr Ser Thr Pro Gln Lys Leu Ile Pro 
    290                 295                 300                 


Pro Gln Pro Thr Gly Arg Pro Ser Pro Ala Pro Pro Ala Val Pro Pro 
305                 310                 315                 320 


Ala Ala Ser Pro Val Met Pro Pro Gln Thr Gln Ser Pro Gly Gln Pro 
                325                 330                 335     


Ala Gln Pro Ala Pro Met Val Pro Leu His Gln Lys Gln Ser Arg Ile 
            340                 345                 350         


Thr Pro Ile Gln Lys Pro Arg Gly Leu Asp Pro Val Glu Ile Leu Gln 
        355                 360                 365             


Glu Arg Glu Tyr Arg Leu Gln Ala Arg Ile Ala His Arg Ile Gln Glu 
    370                 375                 380                 


Leu Glu Asn Leu Pro Gly Ser Leu Ala Gly Asp Leu Arg Thr Lys Ala 
385                 390                 395                 400 


Thr Ile Glu Leu Lys Ala Leu Arg Leu Leu Asn Phe Gln Arg Gln Leu 
                405                 410                 415     


Arg Gln Glu Val Val Val Cys Met Arg Arg Asp Thr Ala Leu Glu Thr 
            420                 425                 430         


Ala Leu Asn Ala Lys Ala Tyr Lys Arg Ser Lys Arg Gln Ser Leu Arg 
        435                 440                 445             


Glu Ala Arg Ile Thr Glu Lys Leu Glu Lys Gln Gln Lys Ile Glu Gln 
    450                 455                 460                 


Glu Arg Lys Arg Arg Gln Lys His Gln Glu Tyr Leu Asn Ser Ile Leu 
465                 470                 475                 480 


Gln His Ala Lys Asp Phe Lys Glu Tyr His Arg Ser Val Thr Gly Lys 
                485                 490                 495     


Ile Gln Lys Leu Thr Lys Ala Val Ala Thr Tyr His Ala Asn Thr Glu 
            500                 505                 510         


Arg Glu Gln Lys Lys Glu Asn Glu Arg Ile Glu Lys Glu Arg Met Arg 
        515                 520                 525             


Arg Leu Met Ala Glu Asp Glu Glu Gly Tyr Arg Lys Leu Ile Asp Gln 
    530                 535                 540                 


Lys Lys Asp Lys Arg Leu Ala Tyr Leu Leu Gln Gln Thr Asp Glu Tyr 
545                 550                 555                 560 


Val Ala Asn Leu Thr Glu Leu Val Arg Gln His Lys Ala Ala Gln Val 
                565                 570                 575     


Ala Lys Glu Lys Lys Lys Lys Lys Lys Lys Lys Lys Ala Glu Asn Ala 
            580                 585                 590         


Glu Gly Gln Thr Pro Ala Ile Gly Pro Asp Gly Glu Pro Leu Asp Glu 
        595                 600                 605             


Thr Ser Gln Met Ser Asp Leu Pro Val Lys Val Ile His Val Glu Ser 
    610                 615                 620                 


Gly Lys Ile Leu Thr Gly Thr Asp Ala Pro Lys Ala Gly Gln Leu Glu 
625                 630                 635                 640 


Ala Trp Leu Glu Met Asn Pro Gly Tyr Glu Val Ala Pro Arg Ser Asp 
                645                 650                 655     


Ser Glu Glu Ser Gly Ser Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu 
            660                 665                 670         


Gln Pro Gln Ala Ala Gln Pro Pro Thr Leu Pro Val Glu Glu Lys Lys 
        675                 680                 685             


Lys Ile Pro Asp Pro Asp Ser Asp Asp Val Ser Glu Val Asp Ala Arg 
    690                 695                 700                 


His Ile Ile Glu Asn Ala Lys Gln Asp Val Asp Asp Glu Tyr Gly Val 
705                 710                 715                 720 


Ser Gln Ala Leu Ala Arg Gly Leu Gln Ser Tyr Tyr Ala Val Ala His 
                725                 730                 735     


Ala Val Thr Glu Arg Val Asp Lys Gln Ser Ala Leu Met Val Asn Gly 
            740                 745                 750         


Val Leu Lys Gln Tyr Gln Ile Lys Gly Leu Glu Trp Leu Val Ser Leu 
        755                 760                 765             


Tyr Asn Asn Asn Leu Asn Gly Ile Leu Ala Asp Glu Met Gly Leu Gly 
    770                 775                 780                 


Lys Thr Ile Gln Thr Ile Ala Leu Ile Thr Tyr Leu Met Glu His Lys 
785                 790                 795                 800 


Arg Ile Asn Gly Pro Phe Leu Ile Ile Val Pro Leu Ser Thr Leu Ser 
                805                 810                 815     


Asn Trp Ala Tyr Glu Phe Asp Lys Trp Ala Pro Ser Val Val Lys Val 
            820                 825                 830         


Ser Tyr Lys Gly Ser Pro Ala Ala Arg Arg Ala Phe Val Pro Gln Leu 
        835                 840                 845             


Arg Ser Gly Lys Phe Asn Val Leu Leu Thr Thr Tyr Glu Tyr Ile Ile 
    850                 855                 860                 


Lys Asp Lys His Ile Leu Ala Lys Ile Arg Trp Lys Tyr Met Ile Val 
865                 870                 875                 880 


Asp Glu Gly His Arg Met Lys Asn His His Cys Lys Leu Thr Gln Val 
                885                 890                 895     


Leu Asn Thr His Tyr Val Ala Pro Arg Arg Leu Leu Leu Thr Gly Thr 
            900                 905                 910         


Pro Leu Gln Asn Lys Leu Pro Glu Leu Trp Ala Leu Leu Asn Phe Leu 
        915                 920                 925             


Leu Pro Thr Ile Phe Lys Ser Cys Ser Thr Phe Glu Gln Trp Phe Asn 
    930                 935                 940                 


Ala Pro Phe Ala Met Thr Gly Glu Lys Val Asp Leu Asn Glu Glu Glu 
945                 950                 955                 960 


Thr Ile Leu Ile Ile Arg Arg Leu His Lys Val Leu Arg Pro Phe Leu 
                965                 970                 975     


Leu Arg Arg Leu Lys Lys Glu Val Glu Ala Gln Leu Pro Glu Lys Val 
            980                 985                 990         


Glu Tyr Val Ile Lys Cys Asp Met  Ser Ala Leu Gln Arg  Val Leu Tyr 
        995                 1000                 1005             


Arg His  Met Gln Ala Lys Gly  Val Leu Leu Thr Asp  Gly Ser Glu 
    1010                 1015                 1020             


Lys Asp  Lys Lys Gly Lys Gly  Gly Thr Lys Thr Leu  Met Asn Thr 
    1025                 1030                 1035             


Ile Met  Gln Leu Arg Lys Ile  Cys Asn His Pro Tyr  Met Phe Gln 
    1040                 1045                 1050             


His Ile  Glu Glu Ser Phe Ser  Glu His Leu Gly Phe  Thr Gly Gly 
    1055                 1060                 1065             


Ile Val  Gln Gly Leu Asp Leu  Tyr Arg Ala Ser Gly  Lys Phe Glu 
    1070                 1075                 1080             


Leu Leu  Asp Arg Ile Leu Pro  Lys Leu Arg Ala Thr  Asn His Lys 
    1085                 1090                 1095             


Val Leu  Leu Phe Cys Gln Met  Thr Ser Leu Met Thr  Ile Met Glu 
    1100                 1105                 1110             


Asp Tyr  Phe Ala Tyr Arg Gly  Phe Lys Tyr Leu Arg  Leu Asp Gly 
    1115                 1120                 1125             


Thr Thr  Lys Ala Glu Asp Arg  Gly Met Leu Leu Lys  Thr Phe Asn 
    1130                 1135                 1140             


Glu Pro  Gly Ser Glu Tyr Phe  Ile Phe Leu Leu Ser  Thr Arg Ala 
    1145                 1150                 1155             


Gly Gly  Leu Gly Leu Asn Leu  Gln Ser Ala Asp Thr  Val Ile Ile 
    1160                 1165                 1170             


Phe Asp  Ser Asp Trp Asn Pro  His Gln Asp Leu Gln  Ala Gln Asp 
    1175                 1180                 1185             


Arg Ala  His Arg Ile Gly Gln  Gln Asn Glu Val Arg  Val Leu Arg 
    1190                 1195                 1200             


Leu Cys  Thr Val Asn Ser Val  Glu Glu Lys Ile Leu  Ala Ala Ala 
    1205                 1210                 1215             


Lys Tyr  Lys Leu Asn Val Asp  Gln Lys Val Ile Gln  Ala Gly Met 
    1220                 1225                 1230             


Phe Asp  Gln Lys Ser Ser Ser  His Glu Arg Arg Ala  Phe Leu Gln 
    1235                 1240                 1245             


Ala Ile  Leu Glu His Glu Glu  Gln Asp Glu Glu Glu  Asp Glu Val 
    1250                 1255                 1260             


Pro Asp  Asp Glu Thr Val Asn  Gln Met Ile Ala Arg  His Glu Glu 
    1265                 1270                 1275             


Glu Phe  Asp Leu Phe Met Arg  Met Asp Leu Asp Arg  Arg Arg Glu 
    1280                 1285                 1290             


Glu Ala  Arg Asn Pro Lys Arg  Lys Pro Arg Leu Met  Glu Glu Asp 
    1295                 1300                 1305             


Glu Leu  Pro Ser Trp Ile Ile  Lys Asp Asp Ala Glu  Val Glu Arg 
    1310                 1315                 1320             


Leu Thr  Cys Glu Glu Glu Glu  Glu Lys Met Phe Gly  Arg Gly Ser 
    1325                 1330                 1335             


Arg His  Arg Lys Glu Val Asp  Tyr Ser Asp Ser Leu  Thr Glu Lys 
    1340                 1345                 1350             


Gln Trp  Leu Lys Ala Ile Glu  Glu Gly Thr Leu Glu  Glu Ile Glu 
    1355                 1360                 1365             


Glu Glu  Val Arg Gln Lys Lys  Ser Ser Arg Lys Arg  Lys Arg Asp 
    1370                 1375                 1380             


Ser Asp  Ala Gly Ser Ser Thr  Pro Thr Thr Ser Thr  Arg Ser Arg 
    1385                 1390                 1395             


Asp Lys  Asp Asp Glu Ser Lys  Lys Gln Lys Lys Arg  Gly Arg Pro 
    1400                 1405                 1410             


Pro Ala  Glu Lys Leu Ser Pro  Asn Pro Pro Asn Leu  Thr Lys Lys 
    1415                 1420                 1425             


Met Lys  Lys Ile Val Asp Ala  Val Ile Lys Tyr Lys  Asp Ser Ser 
    1430                 1435                 1440             


Gly Arg  Gln Leu Ser Glu Val  Phe Ile Gln Leu Pro  Ser Arg Lys 
    1445                 1450                 1455             


Glu Leu  Pro Glu Tyr Tyr Glu  Leu Ile Arg Lys Pro  Val Asp Phe 
    1460                 1465                 1470             


Lys Lys  Ile Lys Glu Arg Ile  Arg Asn His Lys Tyr  Arg Ser Leu 
    1475                 1480                 1485             


Asn Asp  Leu Glu Lys Asp Val  Met Leu Leu Cys Gln  Asn Ala Gln 
    1490                 1495                 1500             


Thr Phe  Asn Leu Glu Gly Ser  Leu Ile Tyr Glu Asp  Ser Ile Val 
    1505                 1510                 1515             


Leu Gln  Ser Val Phe Thr Ser  Val Arg Gln Lys Ile  Glu Lys Glu 
    1520                 1525                 1530             


Asp Asp  Ser Glu Gly Glu Glu  Ser Glu Glu Glu Glu  Glu Gly Glu 
    1535                 1540                 1545             


Glu Glu  Gly Ser Glu Ser Glu  Ser Arg Ser Val Lys  Val Lys Ile 
    1550                 1555                 1560             


Lys Leu  Gly Arg Lys Glu Lys  Ala Gln Asp Arg Leu  Lys Gly Gly 
    1565                 1570                 1575             


Arg Arg  Arg Pro Ser Arg Gly  Ser Arg Ala Lys Pro  Val Val Ser 
    1580                 1585                 1590             


Asp Asp  Asp Ser Glu Glu Glu  Gln Glu Glu Asp Arg  Ser Gly Ser 
    1595                 1600                 1605             


Gly Ser  Glu Glu Asp 
    1610             


<210> 203
<211> 5317
<212> DNA
<213> Homo sapiens

<400> 203
atgtccactc cagacccacc cctgggcgga actcctcggc caggtccttc cccgggccct       60

ggcccttccc ctggagccat gctgggccct agcccgggtc cctcgccggg ctccgcccac      120

agcatgatgg ggcccagccc agggccgccc tcagcaggac accccatccc cacccagggg      180

cctggagggt accctcagga caacatgcac cagatgcaca agcccatgga gtccatgcat      240

gagaagggca tgtcggacga cccgcgctac aaccagatga aaggaatggg gatgcggtca      300

gggggccatg ctgggatggg gcccccgccc agccccatgg accagcactc ccaaggttac      360

ccctcgcccc tgggtggctc tgagcatgcc tctagtccag ttccagccag tggcccgtct      420

tcggggcccc agatgtcttc cgggccagga ggtgccccgc tggatggtgc tgacccccag      480

gccttggggc agcagaaccg gggcccaacc ccatttaacc agaaccagct gcaccagctc      540

agagctcaga tcatggccta caagatgctg gccagggggc agcccctccc cgaccacctg      600

cagatggcgg tgcagggcaa gcggccgatg cccgggatgc agcagcagat gccaacgcta      660

cctccaccct cggtgtccgc aacaggaccc ggccctggcc ctggccctgg ccccggcccg      720

ggtcccggcc cggcacctcc aaattacagc aggcctcatg gtatgggagg gcccaacatg      780

cctcccccag gaccctcggg cgtgcccccc gggatgccag gccagcctcc tggagggcct      840

cccaagccct ggcctgaagg acccatggcg aatgctgctg cccccacgag cacccctcag      900

aagctgattc ccccgcagcc aacgggccgc ccttcccccg cgccccctgc cgtcccaccc      960

gccgcctcgc ccgtgatgcc accgcagacc cagtcccccg ggcagccggc ccagcccgcg     1020

cccatggtgc cactgcacca gaagcagagc cgcatcaccc ccatccagaa gccgcggggc     1080

ctcgaccctg tggagatcct gcaggagcgc gagtacaggc tgcaggctcg catcgcacac     1140

cgaattcagg aacttgaaaa ccttcccggg tccctggccg gggatttgcg aaccaaagcg     1200

accattgagc tcaaggccct caggctgctg aacttccaga ggcagctgcg ccaggaggtg     1260

gtggtgtgca tgcggaggga cacagcgctg gagacagccc tcaatgctaa ggcctacaag     1320

cgcagcaagc gccagtccct gcgcgaggcc cgcatcactg agaagctgga gaagcagcag     1380

aagatcgagc aggagcgcaa gcgccggcag aagcaccagg aatacctcaa tagcattctc     1440

cagcatgcca aggatttcaa ggaatatcac agatccgtca caggcaaaat ccagaagctg     1500

accaaggcag tggccacgta ccatgccaac acggagcggg agcagaagaa agagaacgag     1560

cggatcgaga aggagcgcat gcggaggctc atggctgaag atgaggaggg gtaccgcaag     1620

ctcatcgacc agaagaagga caagcgcctg gcctacctct tgcagcagac agacgagtac     1680

gtggctaacc tcacggagct ggtgcggcag cacaaggctg cccaggtcgc caaggagaaa     1740

aagaagaaaa agaaaaagaa gaaggcagaa aatgcagaag gacagacgcc tgccattggg     1800

ccggatggcg agcctctgga cgagaccagc cagatgagcg acctcccggt gaaggtgatc     1860

cacgtggaga gtgggaagat cctcacaggc acagatgccc ccaaagccgg gcagctggag     1920

gcctggctcg agatgaaccc ggggtatgaa gtagctccga ggtctgatag tgaagaaagt     1980

ggctcagaag aagaggaaga ggaggaggag gaagagcagc cgcaggcagc acagcctccc     2040

accctgcccg tggaggagaa gaagaagatt ccagatccag acagcgatga cgtctctgag     2100

gtggacgcgc ggcacatcat tgagaatgcc aagcaagatg tcgatgatga atatggcgtg     2160

tcccaggccc ttgcacgtgg cctgcagtcc tactatgccg tggcccatgc tgtcactgag     2220

agagtggaca agcagtcagc gcttatggtc aatggtgtcc tcaaacagta ccagatcaaa     2280

ggtttggagt ggctggtgtc cctgtacaac aacaacctga acggcatcct ggccgacgag     2340

atgggcctgg ggaagaccat ccagaccatc gcgctcatca cgtacctcat ggagcacaaa     2400

cgcatcaatg ggcccttcct catcatcgtg cctctctcaa cgctgtccaa ctgggcgtac     2460

gagtttgaca agtgggcccc ctccgtggtg aaggtgtctt acaagggatc cccagcagca     2520

agacgggcct ttgtccccca gctccggagt gggaagttca acgtcttgct gacgacgtac     2580

gagtacatca tcaaagacaa gcacatcctc gccaagatcc gttggaagta catgattgtg     2640

gacgaaggtc accgcatgaa gaaccaccac tgcaagctga cgcaggtgct caacacgcac     2700

tatgtggcac cccgccgcct gctgctgacg ggcacaccgc tgcagaacaa gcttcccgag     2760

ctctgggcgc tgctcaactt cctgctgccc accatcttca agagctgcag caccttcgag     2820

cagtggttta acgcaccctt tgccatgacc ggggaaaagg tggacctgaa tgaggaggaa     2880

accattctca tcatccggcg tctccacaaa gtgctgcggc ccttcttgct ccgacgactc     2940

aagaaggaag tcgaggccca gttgcccgaa aaggtggagt acgtcatcaa gtgcgacatg     3000

tctgcgctgc agcgagtgct ctaccgccac atgcaggcca agggcgtgct gctgactgat     3060

ggctccgaga aggacaagaa gggcaaaggc ggcaccaaga ccctgatgaa caccatcatg     3120

cagctgcgga agatctgcaa ccacccctac atgttccagc acatcgagga gtccttttcc     3180

gagcacttgg ggttcactgg cggcattgtc caagggctgg acctgtaccg agcctcgggt     3240

aaatttgagc ttcttgatag aattcttccc aaactccgag caaccaacca caaagtgctg     3300

ctgttctgcc aaatgacctc cctcatgacc atcatggaag attactttgc gtatcgcggc     3360

tttaaatacc tcaggcttga tggaaccacg aaggcggagg accggggcat gctgctgaaa     3420

accttcaacg agcccggctc tgagtacttc atcttcctgc tcagcacccg ggctgggggg     3480

ctcggcctga acctccagtc ggcagacact gtgatcattt ttgacagcga ctggaatcct     3540

caccaggacc tgcaagcgca ggaccgagcc caccgcatcg ggcagcagaa cgaggtgcgt     3600

gtgctccgcc tctgcaccgt caacagcgtg gaggagaaga tcctagctgc agccaagtac     3660

aagctcaacg tggaccagaa ggtgatccag gccggcatgt tcgaccagaa gtcctccagc     3720

catgagcggc gcgccttcct gcaggccatc ctggagcacg aggagcagga tgaggaggaa     3780

gacgaggtgc ccgacgacga gaccgtcaac cagatgatcg cccggcacga ggaggagttt     3840

gatctgttca tgcgcatgga cctggaccgc aggcgcgagg aggcccgcaa ccccaagcgg     3900

aagccgcgcc tcatggagga ggacgagctc ccctcgtgga tcatcaagga cgacgcggag     3960

gtggagcggc tgacctgtga ggaggaggag gagaagatgt tcggccgtgg ctcccgccac     4020

cgcaaggagg tggactacag cgactcactg acggagaagc agtggctcaa ggccatcgag     4080

gagggcacgc tggaggagat cgaagaggag gtccggcaga agaaatcatc acggaagcgc     4140

aagcgagaca gcgacgccgg ctcctccacc ccgaccacca gcacccgcag ccgcgacaag     4200

gacgacgaga gcaagaagca gaagaagcgc gggcggccgc ctgccgagaa actctcccct     4260

aacccaccca acctcaccaa gaagatgaag aagattgtgg atgccgtgat caagtacaag     4320

gacagcagtg gacgtcagct cagcgaggtc ttcatccagc tgccctcgcg aaaggagctg     4380

cccgagtact acgagctcat ccgcaagccc gtggacttca agaagataaa ggagcgcatt     4440

cgcaaccaca agtaccgcag cctcaacgac ctagagaagg acgtcatgct cctgtgccag     4500

aacgcacaga ccttcaacct ggagggctcc ctgatctatg aagactccat cgtcttgcag     4560

tcggtcttca ccagcgtgcg gcagaaaatc gagaaggagg atgacagtga aggcgaggag     4620

agtgaggagg aggaagaggg cgaggaggaa ggctccgaat ccgaatctcg gtccgtcaaa     4680

gtgaagatca agcttggccg gaaggagaag gcacaggacc ggctgaaggg cggccggcgg     4740

cggccgagcc gagggtcccg agccaagccg gtcgtgagtg acgatgacag tgaggaggaa     4800

caagaggagg accgctcagg aagtggcagc gaagaagact gagccccgac attccagtct     4860

cgaccccgag cccctcgttc cagagctgag atggcatagg ccttagcagt aacgggtagc     4920

agcagatgta gtttcagact tggagtaaaa ctgtataaac aaaagaatct tccatattta     4980

tacagcagag aagctgtagg actgtttgtg actggccctg tcctggcatc agtagcatct     5040

gtaacagcat taactgtctt aaagagagag agagagaatt ccgaattggg gaacacacga     5100

tacctgtttt tcttttccgt tgctggcagt actgttgcgc cgcagtttgg agtcactgta     5160

gttaagtgtg gatgcatgtg cgtcaccgtc cactcctcct actgtatttt attggacagg     5220

tcagactcgc cgggggcccg gcgagggtat gtcagtgtca ctggatgtca aacagtaata     5280

aattaaacca acaacaaaac gcacagccaa aaaaaaa                              5317


<210> 204
<211> 6376
<212> DNA
<213> Mus musculus

<400> 204
ggcaagtgga gcgggtagac agggaggcgg gggcgcgcgg cgggcgcgtg cggtgggggg       60

gggtggcctg gcgaagccca gcgggcgcgc gcgcgaggct ttcccactcg cttggcagcg      120

gcggagacgg cttctttgtt tcctgaggag aagcgagacg cccactctgt ccccgacccc      180

tcgtggaggg ttgggggcgg cgccaggaag gttacggcgc cgttacctcc aggagaccag      240

tgcctgtagc tccagtaaag atgtctactc cagacccacc cttgggtggg actcctcggc      300

ctggtccttc cccaggccct ggtccttcac ctggtgcaat gctgggtcct agccctggcc      360

cctcaccagg ttctgcccac agcatgatgg ggccaagccc aggacctcct tcagcaggac      420

atcccatgcc cacccagggg cctggagggt acccccagga caacatgcat cagatgcaca      480

agcctatgga gtccatgcac gagaagggca tgcctgatga cccacgatac aaccagatga      540

aagggatggg catgcggtca ggggcccaca caggcatggc acctccacct agtcccatgg      600

accagcattc tcaaggttac ccctcacccc tcggcggctc tgaacatgcc tccagtcctg      660

tcccagccag tggcccatct tcaggccccc agatgtcctc tgggccagga ggggccccac      720

tagatggttc tgatccccag gccttgggac agcaaaacag aggcccaacc ccatttaacc      780

agaaccagct gcatcaactc agagctcaga taatggccta caagatgttg gccaggggcc      840

agccattgcc cgaccacctg cagatggccg tgcaaggcaa gcggccgatg cctggaatgc      900

agcaacagat gccaacacta cctccaccct cagtgtccgc cacaggaccc ggacctggac      960

ccggccctgg ccctggccct ggcccaggac cagcccctcc aaattacagt agaccccatg     1020

gtatgggagg gcccaacatg cctcccccag gaccctcagg tgtgcccccc gggatgcctg     1080

gtcagccgcc tggagggcct cccaagccat ggcctgaagg acccatggcc aatgctgctg     1140

cccccacaag caccccacag aagctgattc ctccgcaacc aacaggccgt ccttcacctg     1200

cacctcctgc tgtcccgcct gctgcctcac ctgtaatgcc accacaaaca cagtccccag     1260

ggcagccagc ccagcctgct ccattggtgc cactgcacca gaagcagagc cgaatcaccc     1320

ccatccagaa gccccgaggc cttgaccctg tggagatcct acaagagcgg gagtacaggc     1380

ttcaggctcg aatcgcacac agaattcagg aacttgaaaa cctccctggg tccctggctg     1440

gggaccttcg aaccaaagca accatcgaac tcaaggccct taggttgctg aacttccaga     1500

ggcagctgcg ccaggaggtg gtggtgtgca tgcgaagaga cacagccctg gagacagccc     1560

tcaatgccaa ggcctacaag cgcagcaaac gtcagtcact acgggaggcc cgcatcactg     1620

agaagttgga gaagcagcag aagattgaac aggagcgcaa gcgccgccag aagcaccagg     1680

agtacctcaa cagcattctg cagcatgcca aggacttcag ggagtatcac agatcagtca     1740

caggcaaact ccagaaactc accaaggctg tggccaccta ccatgccaac actgagcggg     1800

agcagaagaa agaaaatgag cgcattgaga aggagcgaat gcggaggctt atggctgaag     1860

atgaggaggg ctaccgcaaa ctcattgacc agaagaagga caagcgcctg gcctaccttc     1920

tgcagcagac agatgagtat gtggccaacc tcacagagct ggtgcggcag cacaaagctg     1980

cccaggttgc caaggagaag aagaagaaaa agaaaaagaa gaaggcagaa aatgctgaag     2040

gacagacacc tgctattgga ccagatggtg agcctctgga tgagaccagc cagatgagtg     2100

acctccctgt gaaggtgatc cacgtggaga gtggcaagat cctcactggc acagatgccc     2160

caaaagccgg gcagctggaa gcctggcttg aaatgaaccc agggtatgaa gtagccccca     2220

ggtcagacag tgaagaaagt ggctctgaag aggaggagga ggaggaggaa gaggagcagc     2280

ctcagcccgc acagccccct acactgcctg tggaagaaaa gaagaagatt ccagacccag     2340

acagcgatga tgtctctgag gtggacgccc gacacattat tgagaacgcc aagcaagatg     2400

tggacgatga gtacggtgtg tcccaggccc ttgctcgtgg cctgcagtct tactatgctg     2460

tggcccatgc agtcacagag agagtagata agcagtccgc cctcatggtc aacggtgtcc     2520

tcaaacagta ccagatcaag ggtttggagt ggctggtgtc cctgtacaac aacaacctga     2580

atggcatcct ggctgatgag atggggctgg ggaagaccat ccagaccatc gcgctcatca     2640

catacctcat ggagcacaag cgcatcaacg ggcctttcct catcatcgtg cctctctcga     2700

cactgtcaaa ctgggcgtat gaatttgaca agtgggcccc ctctgtggtg aaggtttctt     2760

acaagggctc tccagctgca aggcgagctt ttgtcccaca gcttcgcagt gggaagttca     2820

acgtcttact gaccacctat gaatatatca tcaaagacaa gcatatccta gccaagatcc     2880

gctggaagta catgattgtg gatgaaggcc accgcatgaa aaaccaccac tgcaagttga     2940

cgcaggtcct taacacacac tacgtggccc ctcggcgcct gcttcttaca ggcacaccac     3000

tgcagaacaa gctaccggag ctctgggccc tgcttaactt cctgctcccc actatcttca     3060

agagctgcag caccttcgaa cagtggttca atgcaccctt tgccatgact ggagaaaagg     3120

tggacctgaa tgaagaggag actatcctca ttattcgtcg cctacacaaa gttctgcggc     3180

ccttcctgct gcggcggctc aagaaggaag ttgaagccca gctccctgag aaggtagagt     3240

atgtcatcaa atgcgacatg tcagccctgc agcgtgtgct gtaccgtcac atgcaggcca     3300

aaggtgtgct gctgactgac ggctccgaga aggacaagaa gggcaaaggt ggcaccaaga     3360

cactgatgaa cactattatg caactgcgta agatctgcaa ccacccctac atgttccagc     3420

acatcgagga gtccttttct gagcacttgg ggttcaccgg cggcatcgtg caaggattgg     3480

acctttaccg tgcctcaggg aaatttgaac ttcttgatag aattctaccc aaactccgtg     3540

caacgaacca taaagtgctc ctcttttgcc aaatgacctc cctcatgacc atcatggaag     3600

actactttgc ataccgtggc ttcaaatacc tcaggcttga tggaaccaca aaagcagaag     3660

accggggcat gctgttgaaa acctttaatg aacctggctc tgagtatttc attttcctgc     3720

tcagtacccg tgctgggggg ctgggcctga atctgcagtc agctgacact gtgatcatct     3780

ttgacagtga ctggaatccc caccaggacc tgcaagcaca ggatcgagcc catcgcattg     3840

gacagcagaa tgaggtgcgt gttcttcgcc tgtgcacggt caacagtgtg gaagagaaga     3900

tactggctgc tgccaaatac aaactcaatg tggatcagaa ggtgatccag gcaggcatgt     3960

tcgaccagaa gtcgtccagc catgagaggc gtgccttcct gcaggccatc ctggagcacg     4020

aggagcagga tgaggaggaa gatgaggtgc ctgatgatga gaccgtcaac cagatgattg     4080

cccggcacga agaagagttt gacctcttca tgcgcatgga cttggaccgc cggcgtgaag     4140

aagcccgcaa ccccaagcgg aagccacgcc tgatggaaga ggatgagctc ccatcctgga     4200

tcatcaagga tgatgccgag gtggagcggc tgacatgtga agaggaagag gagaagatgt     4260

tcggccgtgg ttctcgccac cgcaaggagg tagactacag cgactcactg acagagaagc     4320

agtggctcaa gaccctgaag gctatcgagg agggcacgct ggaggagatc gaagaggagg     4380

tccggcagaa gaaatcttca cgtaagcgta agcgagacag cgaggccggc tcctccaccc     4440

cgaccaccag cacccgcagc cgtgacaagg atgaggagag caagaagcag aagaaacgtg     4500

ggcggccacc tgctgagaag ctgtccccaa acccacctaa cctcaccaag aagatgaaga     4560

agatcgtgga tgctgtgatc aagtacaaag acagcagcag tggacgtcag ctcagcgagg     4620

tgttcatcca gctcccctct cgcaaggagc ttcctgagta ctatgagctc atccgaaagc     4680

ctgtggactt caagaagatc aaggaacgca tccgaaacca caagtaccgc agcctcaatg     4740

acctggagaa ggatgtgatg ctgctgtgcc agaacgctca gacgttcaac ctcgagggtt     4800

ccctgatcta tgaggactcc atcgtcctgc agtctgtctt caccagcgta cggcagaaga     4860

ttgagaagga ggacgacagt gaaggcgagg aaagcgagga ggaggaggag ggcgaggagg     4920

aaggctccga gtctgagtcc cgctccgtca aggtgaagat caagctgggc cgcaaggaga     4980

aggcccagga ccgactcaag gggggccgcc ggcggccaag ccggggatcc cgggccaagc     5040

cggttgtgag tgacgatgac agtgaggagg agcaggagga ggaccgctca ggaagtggca     5100

gtgaggaaga ctgaaccaga cattcctgag tcctgacccc gaggcgctcg tcccagccaa     5160

gatggagtag cccttagcag tgatgggtag caccagatgt agtttcgaac ttggagaact     5220

gtacacatgc aatcttccac atttttaggc agagaagtat aggcctgtct gtcggccctg     5280

gcctggcctc gagtctctac cagcattaac tgtctagaga ggggacctcc tgggagcacc     5340

atccacctcc ccaggcccca gtcactgtag ctcagtggat gcatgcgcgt gccggccgct     5400

ccttgtactg tatcttactg gacagggcca gctctccagg aggctcacag gcccagcggg     5460

tatgtcagtg tcactggagt cagacagtaa taaattaaag caatgacaag ccaccactgg     5520

ctccctggac tccttgctgt cagcagtggc tccggggcca cagagaagaa agaaagactt     5580

ttaggaactg ggtctaactt atgggcaaag tacttgcctt gccaggtgta tgggttttgc     5640

attcccatca cccacacacc ctaaacaagc caagtcagtg agcttcaagt tagagcctcc     5700

acctcaatgt gtacgtggaa agcaatcaaa gatgatgcct agcatccacc tctggccctc     5760

atgtgcagat gtacacacac tgaattacat acacgggaca cacacatcca cacggaggca     5820

gtccatgact tgcactgggg agatggtacc ataggcgaaa gtgccacagg cacagggcca     5880

ggctaattta gtcctgcagt cctgtgctct taagatgaag gcacaaagag gaaccccagg     5940

cgctccaact agcatgccag gcagtgacaa gaccctgctt caaatgaatc agagcccaca     6000

ttcagtattg ccctcttacc cgatgcgatg cccatgccct cacatatgaa tgtgtatata     6060

tacatacata cgtaaaataa ttctttttta aattatagac atttttgtgt gaatgttttg     6120

cctgaatgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tatcaagtac     6180

attcctagag cctacagagg tcaagggagg gcattggatc tggaactgga gtcacatgag     6240

gctgtgagca actgtgtggg ttcctgggcc tttgcaacag cagttagtac tcttcaccac     6300

tgagccattt ctccaatctc aaaaagaagc attcttttaa atgaagactg aaataaataa     6360

gtaggacttg ccttgg                                                     6376


<210> 205
<211> 1617
<212> PRT
<213> Mus musculus

<400> 205
Met Ser Thr Pro Asp Pro Pro Leu Gly Gly Thr Pro Arg Pro Gly Pro 
1               5                   10                  15      


Ser Pro Gly Pro Gly Pro Ser Pro Gly Ala Met Leu Gly Pro Ser Pro 
            20                  25                  30          


Gly Pro Ser Pro Gly Ser Ala His Ser Met Met Gly Pro Ser Pro Gly 
        35                  40                  45              


Pro Pro Ser Ala Gly His Pro Met Pro Thr Gln Gly Pro Gly Gly Tyr 
    50                  55                  60                  


Pro Gln Asp Asn Met His Gln Met His Lys Pro Met Glu Ser Met His 
65                  70                  75                  80  


Glu Lys Gly Met Pro Asp Asp Pro Arg Tyr Asn Gln Met Lys Gly Met 
                85                  90                  95      


Gly Met Arg Ser Gly Ala His Thr Gly Met Ala Pro Pro Pro Ser Pro 
            100                 105                 110         


Met Asp Gln His Ser Gln Gly Tyr Pro Ser Pro Leu Gly Gly Ser Glu 
        115                 120                 125             


His Ala Ser Ser Pro Val Pro Ala Ser Gly Pro Ser Ser Gly Pro Gln 
    130                 135                 140                 


Met Ser Ser Gly Pro Gly Gly Ala Pro Leu Asp Gly Ser Asp Pro Gln 
145                 150                 155                 160 


Ala Leu Gly Gln Gln Asn Arg Gly Pro Thr Pro Phe Asn Gln Asn Gln 
                165                 170                 175     


Leu His Gln Leu Arg Ala Gln Ile Met Ala Tyr Lys Met Leu Ala Arg 
            180                 185                 190         


Gly Gln Pro Leu Pro Asp His Leu Gln Met Ala Val Gln Gly Lys Arg 
        195                 200                 205             


Pro Met Pro Gly Met Gln Gln Gln Met Pro Thr Leu Pro Pro Pro Ser 
    210                 215                 220                 


Val Ser Ala Thr Gly Pro Gly Pro Gly Pro Gly Pro Gly Pro Gly Pro 
225                 230                 235                 240 


Gly Pro Gly Pro Ala Pro Pro Asn Tyr Ser Arg Pro His Gly Met Gly 
                245                 250                 255     


Gly Pro Asn Met Pro Pro Pro Gly Pro Ser Gly Val Pro Pro Gly Met 
            260                 265                 270         


Pro Gly Gln Pro Pro Gly Gly Pro Pro Lys Pro Trp Pro Glu Gly Pro 
        275                 280                 285             


Met Ala Asn Ala Ala Ala Pro Thr Ser Thr Pro Gln Lys Leu Ile Pro 
    290                 295                 300                 


Pro Gln Pro Thr Gly Arg Pro Ser Pro Ala Pro Pro Ala Val Pro Pro 
305                 310                 315                 320 


Ala Ala Ser Pro Val Met Pro Pro Gln Thr Gln Ser Pro Gly Gln Pro 
                325                 330                 335     


Ala Gln Pro Ala Pro Leu Val Pro Leu His Gln Lys Gln Ser Arg Ile 
            340                 345                 350         


Thr Pro Ile Gln Lys Pro Arg Gly Leu Asp Pro Val Glu Ile Leu Gln 
        355                 360                 365             


Glu Arg Glu Tyr Arg Leu Gln Ala Arg Ile Ala His Arg Ile Gln Glu 
    370                 375                 380                 


Leu Glu Asn Leu Pro Gly Ser Leu Ala Gly Asp Leu Arg Thr Lys Ala 
385                 390                 395                 400 


Thr Ile Glu Leu Lys Ala Leu Arg Leu Leu Asn Phe Gln Arg Gln Leu 
                405                 410                 415     


Arg Gln Glu Val Val Val Cys Met Arg Arg Asp Thr Ala Leu Glu Thr 
            420                 425                 430         


Ala Leu Asn Ala Lys Ala Tyr Lys Arg Ser Lys Arg Gln Ser Leu Arg 
        435                 440                 445             


Glu Ala Arg Ile Thr Glu Lys Leu Glu Lys Gln Gln Lys Ile Glu Gln 
    450                 455                 460                 


Glu Arg Lys Arg Arg Gln Lys His Gln Glu Tyr Leu Asn Ser Ile Leu 
465                 470                 475                 480 


Gln His Ala Lys Asp Phe Arg Glu Tyr His Arg Ser Val Thr Gly Lys 
                485                 490                 495     


Leu Gln Lys Leu Thr Lys Ala Val Ala Thr Tyr His Ala Asn Thr Glu 
            500                 505                 510         


Arg Glu Gln Lys Lys Glu Asn Glu Arg Ile Glu Lys Glu Arg Met Arg 
        515                 520                 525             


Arg Leu Met Ala Glu Asp Glu Glu Gly Tyr Arg Lys Leu Ile Asp Gln 
    530                 535                 540                 


Lys Lys Asp Lys Arg Leu Ala Tyr Leu Leu Gln Gln Thr Asp Glu Tyr 
545                 550                 555                 560 


Val Ala Asn Leu Thr Glu Leu Val Arg Gln His Lys Ala Ala Gln Val 
                565                 570                 575     


Ala Lys Glu Lys Lys Lys Lys Lys Lys Lys Lys Lys Ala Glu Asn Ala 
            580                 585                 590         


Glu Gly Gln Thr Pro Ala Ile Gly Pro Asp Gly Glu Pro Leu Asp Glu 
        595                 600                 605             


Thr Ser Gln Met Ser Asp Leu Pro Val Lys Val Ile His Val Glu Ser 
    610                 615                 620                 


Gly Lys Ile Leu Thr Gly Thr Asp Ala Pro Lys Ala Gly Gln Leu Glu 
625                 630                 635                 640 


Ala Trp Leu Glu Met Asn Pro Gly Tyr Glu Val Ala Pro Arg Ser Asp 
                645                 650                 655     


Ser Glu Glu Ser Gly Ser Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu 
            660                 665                 670         


Gln Pro Gln Pro Ala Gln Pro Pro Thr Leu Pro Val Glu Glu Lys Lys 
        675                 680                 685             


Lys Ile Pro Asp Pro Asp Ser Asp Asp Val Ser Glu Val Asp Ala Arg 
    690                 695                 700                 


His Ile Ile Glu Asn Ala Lys Gln Asp Val Asp Asp Glu Tyr Gly Val 
705                 710                 715                 720 


Ser Gln Ala Leu Ala Arg Gly Leu Gln Ser Tyr Tyr Ala Val Ala His 
                725                 730                 735     


Ala Val Thr Glu Arg Val Asp Lys Gln Ser Ala Leu Met Val Asn Gly 
            740                 745                 750         


Val Leu Lys Gln Tyr Gln Ile Lys Gly Leu Glu Trp Leu Val Ser Leu 
        755                 760                 765             


Tyr Asn Asn Asn Leu Asn Gly Ile Leu Ala Asp Glu Met Gly Leu Gly 
    770                 775                 780                 


Lys Thr Ile Gln Thr Ile Ala Leu Ile Thr Tyr Leu Met Glu His Lys 
785                 790                 795                 800 


Arg Ile Asn Gly Pro Phe Leu Ile Ile Val Pro Leu Ser Thr Leu Ser 
                805                 810                 815     


Asn Trp Ala Tyr Glu Phe Asp Lys Trp Ala Pro Ser Val Val Lys Val 
            820                 825                 830         


Ser Tyr Lys Gly Ser Pro Ala Ala Arg Arg Ala Phe Val Pro Gln Leu 
        835                 840                 845             


Arg Ser Gly Lys Phe Asn Val Leu Leu Thr Thr Tyr Glu Tyr Ile Ile 
    850                 855                 860                 


Lys Asp Lys His Ile Leu Ala Lys Ile Arg Trp Lys Tyr Met Ile Val 
865                 870                 875                 880 


Asp Glu Gly His Arg Met Lys Asn His His Cys Lys Leu Thr Gln Val 
                885                 890                 895     


Leu Asn Thr His Tyr Val Ala Pro Arg Arg Leu Leu Leu Thr Gly Thr 
            900                 905                 910         


Pro Leu Gln Asn Lys Leu Pro Glu Leu Trp Ala Leu Leu Asn Phe Leu 
        915                 920                 925             


Leu Pro Thr Ile Phe Lys Ser Cys Ser Thr Phe Glu Gln Trp Phe Asn 
    930                 935                 940                 


Ala Pro Phe Ala Met Thr Gly Glu Lys Val Asp Leu Asn Glu Glu Glu 
945                 950                 955                 960 


Thr Ile Leu Ile Ile Arg Arg Leu His Lys Val Leu Arg Pro Phe Leu 
                965                 970                 975     


Leu Arg Arg Leu Lys Lys Glu Val Glu Ala Gln Leu Pro Glu Lys Val 
            980                 985                 990         


Glu Tyr Val Ile Lys Cys Asp Met  Ser Ala Leu Gln Arg  Val Leu Tyr 
        995                 1000                 1005             


Arg His  Met Gln Ala Lys Gly  Val Leu Leu Thr Asp  Gly Ser Glu 
    1010                 1015                 1020             


Lys Asp  Lys Lys Gly Lys Gly  Gly Thr Lys Thr Leu  Met Asn Thr 
    1025                 1030                 1035             


Ile Met  Gln Leu Arg Lys Ile  Cys Asn His Pro Tyr  Met Phe Gln 
    1040                 1045                 1050             


His Ile  Glu Glu Ser Phe Ser  Glu His Leu Gly Phe  Thr Gly Gly 
    1055                 1060                 1065             


Ile Val  Gln Gly Leu Asp Leu  Tyr Arg Ala Ser Gly  Lys Phe Glu 
    1070                 1075                 1080             


Leu Leu  Asp Arg Ile Leu Pro  Lys Leu Arg Ala Thr  Asn His Lys 
    1085                 1090                 1095             


Val Leu  Leu Phe Cys Gln Met  Thr Ser Leu Met Thr  Ile Met Glu 
    1100                 1105                 1110             


Asp Tyr  Phe Ala Tyr Arg Gly  Phe Lys Tyr Leu Arg  Leu Asp Gly 
    1115                 1120                 1125             


Thr Thr  Lys Ala Glu Asp Arg  Gly Met Leu Leu Lys  Thr Phe Asn 
    1130                 1135                 1140             


Glu Pro  Gly Ser Glu Tyr Phe  Ile Phe Leu Leu Ser  Thr Arg Ala 
    1145                 1150                 1155             


Gly Gly  Leu Gly Leu Asn Leu  Gln Ser Ala Asp Thr  Val Ile Ile 
    1160                 1165                 1170             


Phe Asp  Ser Asp Trp Asn Pro  His Gln Asp Leu Gln  Ala Gln Asp 
    1175                 1180                 1185             


Arg Ala  His Arg Ile Gly Gln  Gln Asn Glu Val Arg  Val Leu Arg 
    1190                 1195                 1200             


Leu Cys  Thr Val Asn Ser Val  Glu Glu Lys Ile Leu  Ala Ala Ala 
    1205                 1210                 1215             


Lys Tyr  Lys Leu Asn Val Asp  Gln Lys Val Ile Gln  Ala Gly Met 
    1220                 1225                 1230             


Phe Asp  Gln Lys Ser Ser Ser  His Glu Arg Arg Ala  Phe Leu Gln 
    1235                 1240                 1245             


Ala Ile  Leu Glu His Glu Glu  Gln Asp Glu Glu Glu  Asp Glu Val 
    1250                 1255                 1260             


Pro Asp  Asp Glu Thr Val Asn  Gln Met Ile Ala Arg  His Glu Glu 
    1265                 1270                 1275             


Glu Phe  Asp Leu Phe Met Arg  Met Asp Leu Asp Arg  Arg Arg Glu 
    1280                 1285                 1290             


Glu Ala  Arg Asn Pro Lys Arg  Lys Pro Arg Leu Met  Glu Glu Asp 
    1295                 1300                 1305             


Glu Leu  Pro Ser Trp Ile Ile  Lys Asp Asp Ala Glu  Val Glu Arg 
    1310                 1315                 1320             


Leu Thr  Cys Glu Glu Glu Glu  Glu Lys Met Phe Gly  Arg Gly Ser 
    1325                 1330                 1335             


Arg His  Arg Lys Glu Val Asp  Tyr Ser Asp Ser Leu  Thr Glu Lys 
    1340                 1345                 1350             


Gln Trp  Leu Lys Thr Leu Lys  Ala Ile Glu Glu Gly  Thr Leu Glu 
    1355                 1360                 1365             


Glu Ile  Glu Glu Glu Val Arg  Gln Lys Lys Ser Ser  Arg Lys Arg 
    1370                 1375                 1380             


Lys Arg  Asp Ser Glu Ala Gly  Ser Ser Thr Pro Thr  Thr Ser Thr 
    1385                 1390                 1395             


Arg Ser  Arg Asp Lys Asp Glu  Glu Ser Lys Lys Gln  Lys Lys Arg 
    1400                 1405                 1410             


Gly Arg  Pro Pro Ala Glu Lys  Leu Ser Pro Asn Pro  Pro Asn Leu 
    1415                 1420                 1425             


Thr Lys  Lys Met Lys Lys Ile  Val Asp Ala Val Ile  Lys Tyr Lys 
    1430                 1435                 1440             


Asp Ser  Ser Ser Gly Arg Gln  Leu Ser Glu Val Phe  Ile Gln Leu 
    1445                 1450                 1455             


Pro Ser  Arg Lys Glu Leu Pro  Glu Tyr Tyr Glu Leu  Ile Arg Lys 
    1460                 1465                 1470             


Pro Val  Asp Phe Lys Lys Ile  Lys Glu Arg Ile Arg  Asn His Lys 
    1475                 1480                 1485             


Tyr Arg  Ser Leu Asn Asp Leu  Glu Lys Asp Val Met  Leu Leu Cys 
    1490                 1495                 1500             


Gln Asn  Ala Gln Thr Phe Asn  Leu Glu Gly Ser Leu  Ile Tyr Glu 
    1505                 1510                 1515             


Asp Ser  Ile Val Leu Gln Ser  Val Phe Thr Ser Val  Arg Gln Lys 
    1520                 1525                 1530             


Ile Glu  Lys Glu Asp Asp Ser  Glu Gly Glu Glu Ser  Glu Glu Glu 
    1535                 1540                 1545             


Glu Glu  Gly Glu Glu Glu Gly  Ser Glu Ser Glu Ser  Arg Ser Val 
    1550                 1555                 1560             


Lys Val  Lys Ile Lys Leu Gly  Arg Lys Glu Lys Ala  Gln Asp Arg 
    1565                 1570                 1575             


Leu Lys  Gly Gly Arg Arg Arg  Pro Ser Arg Gly Ser  Arg Ala Lys 
    1580                 1585                 1590             


Pro Val  Val Ser Asp Asp Asp  Ser Glu Glu Glu Gln  Glu Glu Asp 
    1595                 1600                 1605             


Arg Ser  Gly Ser Gly Ser Glu  Glu Asp 
    1610                 1615         


<210> 206
<211> 6367
<212> DNA
<213> Mus musculus

<400> 206
ggcaagtgga gcgggtagac agggaggcgg gggcgcgcgg cgggcgcgtg cggtgggggg       60

gggtggcctg gcgaagccca gcgggcgcgc gcgcgaggct ttcccactcg cttggcagcg      120

gcggagacgg cttctttgtt tcctgaggag aagcgagacg cccactctgt ccccgacccc      180

tcgtggaggg ttgggggcgg cgccaggaag gttacggcgc cgttacctcc aggagaccag      240

tgcctgtagc tccagtaaag atgtctactc cagacccacc cttgggtggg actcctcggc      300

ctggtccttc cccaggccct ggtccttcac ctggtgcaat gctgggtcct agccctggcc      360

cctcaccagg ttctgcccac agcatgatgg ggccaagccc aggacctcct tcagcaggac      420

atcccatgcc cacccagggg cctggagggt acccccagga caacatgcat cagatgcaca      480

agcctatgga gtccatgcac gagaagggca tgcctgatga cccacgatac aaccagatga      540

aagggatggg catgcggtca ggggcccaca caggcatggc acctccacct agtcccatgg      600

accagcattc tcaaggttac ccctcacccc tcggcggctc tgaacatgcc tccagtcctg      660

tcccagccag tggcccatct tcaggccccc agatgtcctc tgggccagga ggggccccac      720

tagatggttc tgatccccag gccttgggac agcaaaacag aggcccaacc ccatttaacc      780

agaaccagct gcatcaactc agagctcaga taatggccta caagatgttg gccaggggcc      840

agccattgcc cgaccacctg cagatggccg tgcaaggcaa gcggccgatg cctggaatgc      900

agcaacagat gccaacacta cctccaccct cagtgtccgc cacaggaccc ggacctggac      960

ccggccctgg ccctggccct ggcccaggac cagcccctcc aaattacagt agaccccatg     1020

gtatgggagg gcccaacatg cctcccccag gaccctcagg tgtgcccccc gggatgcctg     1080

gtcagccgcc tggagggcct cccaagccat ggcctgaagg acccatggcc aatgctgctg     1140

cccccacaag caccccacag aagctgattc ctccgcaacc aacaggccgt ccttcacctg     1200

cacctcctgc tgtcccgcct gctgcctcac ctgtaatgcc accacaaaca cagtccccag     1260

ggcagccagc ccagcctgct ccattggtgc cactgcacca gaagcagagc cgaatcaccc     1320

ccatccagaa gccccgaggc cttgaccctg tggagatcct acaagagcgg gagtacaggc     1380

ttcaggctcg aatcgcacac agaattcagg aacttgaaaa cctccctggg tccctggctg     1440

gggaccttcg aaccaaagca accatcgaac tcaaggccct taggttgctg aacttccaga     1500

ggcagctgcg ccaggaggtg gtggtgtgca tgcgaagaga cacagccctg gagacagccc     1560

tcaatgccaa ggcctacaag cgcagcaaac gtcagtcact acgggaggcc cgcatcactg     1620

agaagttgga gaagcagcag aagattgaac aggagcgcaa gcgccgccag aagcaccagg     1680

agtacctcaa cagcattctg cagcatgcca aggacttcag ggagtatcac agatcagtca     1740

caggcaaact ccagaaactc accaaggctg tggccaccta ccatgccaac actgagcggg     1800

agcagaagaa agaaaatgag cgcattgaga aggagcgaat gcggaggctt atggctgaag     1860

atgaggaggg ctaccgcaaa ctcattgacc agaagaagga caagcgcctg gcctaccttc     1920

tgcagcagac agatgagtat gtggccaacc tcacagagct ggtgcggcag cacaaagctg     1980

cccaggttgc caaggagaag aagaagaaaa agaaaaagaa gaaggcagaa aatgctgaag     2040

gacagacacc tgctattgga ccagatggtg agcctctgga tgagaccagc cagatgagtg     2100

acctccctgt gaaggtgatc cacgtggaga gtggcaagat cctcactggc acagatgccc     2160

caaaagccgg gcagctggaa gcctggcttg aaatgaaccc agggtatgaa gtagccccca     2220

ggtcagacag tgaagaaagt ggctctgaag aggaggagga ggaggaggaa gaggagcagc     2280

ctcagcccgc acagccccct acactgcctg tggaagaaaa gaagaagatt ccagacccag     2340

acagcgatga tgtctctgag gtggacgccc gacacattat tgagaacgcc aagcaagatg     2400

tggacgatga gtacggtgtg tcccaggccc ttgctcgtgg cctgcagtct tactatgctg     2460

tggcccatgc agtcacagag agagtagata agcagtccgc cctcatggtc aacggtgtcc     2520

tcaaacagta ccagatcaag ggtttggagt ggctggtgtc cctgtacaac aacaacctga     2580

atggcatcct ggctgatgag atggggctgg ggaagaccat ccagaccatc gcgctcatca     2640

catacctcat ggagcacaag cgcatcaacg ggcctttcct catcatcgtg cctctctcga     2700

cactgtcaaa ctgggcgtat gaatttgaca agtgggcccc ctctgtggtg aaggtttctt     2760

acaagggctc tccagctgca aggcgagctt ttgtcccaca gcttcgcagt gggaagttca     2820

acgtcttact gaccacctat gaatatatca tcaaagacaa gcatatccta gccaagatcc     2880

gctggaagta catgattgtg gatgaaggcc accgcatgaa aaaccaccac tgcaagttga     2940

cgcaggtcct taacacacac tacgtggccc ctcggcgcct gcttcttaca ggcacaccac     3000

tgcagaacaa gctaccggag ctctgggccc tgcttaactt cctgctcccc actatcttca     3060

agagctgcag caccttcgaa cagtggttca atgcaccctt tgccatgact ggagaaaagg     3120

tggacctgaa tgaagaggag actatcctca ttattcgtcg cctacacaaa gttctgcggc     3180

ccttcctgct gcggcggctc aagaaggaag ttgaagccca gctccctgag aaggtagagt     3240

atgtcatcaa atgcgacatg tcagccctgc agcgtgtgct gtaccgtcac atgcaggcca     3300

aaggtgtgct gctgactgac ggctccgaga aggacaagaa gggcaaaggt ggcaccaaga     3360

cactgatgaa cactattatg caactgcgta agatctgcaa ccacccctac atgttccagc     3420

acatcgagga gtccttttct gagcacttgg ggttcaccgg cggcatcgtg caaggattgg     3480

acctttaccg tgcctcaggg aaatttgaac ttcttgatag aattctaccc aaactccgtg     3540

caacgaacca taaagtgctc ctcttttgcc aaatgacctc cctcatgacc atcatggaag     3600

actactttgc ataccgtggc ttcaaatacc tcaggcttga tggaaccaca aaagcagaag     3660

accggggcat gctgttgaaa acctttaatg aacctggctc tgagtatttc attttcctgc     3720

tcagtacccg tgctgggggg ctgggcctga atctgcagtc agctgacact gtgatcatct     3780

ttgacagtga ctggaatccc caccaggacc tgcaagcaca ggatcgagcc catcgcattg     3840

gacagcagaa tgaggtgcgt gttcttcgcc tgtgcacggt caacagtgtg gaagagaaga     3900

tactggctgc tgccaaatac aaactcaatg tggatcagaa ggtgatccag gcaggcatgt     3960

tcgaccagaa gtcgtccagc catgagaggc gtgccttcct gcaggccatc ctggagcacg     4020

aggagcagga tgaggaggaa gatgaggtgc ctgatgatga gaccgtcaac cagatgattg     4080

cccggcacga agaagagttt gacctcttca tgcgcatgga cttggaccgc cggcgtgaag     4140

aagcccgcaa ccccaagcgg aagccacgcc tgatggaaga ggatgagctc ccatcctgga     4200

tcatcaagga tgatgccgag gtggagcggc tgacatgtga agaggaagag gagaagatgt     4260

tcggccgtgg ttctcgccac cgcaaggagg tagactacag cgactcactg acagagaagc     4320

agtggctcaa ggctatcgag gagggcacgc tggaggagat cgaagaggag gtccggcaga     4380

agaaatcttc acgtaagcgt aagcgagaca gcgaggccgg ctcctccacc ccgaccacca     4440

gcacccgcag ccgtgacaag gatgaggaga gcaagaagca gaagaaacgt gggcggccac     4500

ctgctgagaa gctgtcccca aacccaccta acctcaccaa gaagatgaag aagatcgtgg     4560

atgctgtgat caagtacaaa gacagcagca gtggacgtca gctcagcgag gtgttcatcc     4620

agctcccctc tcgcaaggag cttcctgagt actatgagct catccgaaag cctgtggact     4680

tcaagaagat caaggaacgc atccgaaacc acaagtaccg cagcctcaat gacctggaga     4740

aggatgtgat gctgctgtgc cagaacgctc agacgttcaa cctcgagggt tccctgatct     4800

atgaggactc catcgtcctg cagtctgtct tcaccagcgt acggcagaag attgagaagg     4860

aggacgacag tgaaggcgag gaaagcgagg aggaggagga gggcgaggag gaaggctccg     4920

agtctgagtc ccgctccgtc aaggtgaaga tcaagctggg ccgcaaggag aaggcccagg     4980

accgactcaa ggggggccgc cggcggccaa gccggggatc ccgggccaag ccggttgtga     5040

gtgacgatga cagtgaggag gagcaggagg aggaccgctc aggaagtggc agtgaggaag     5100

actgaaccag acattcctga gtcctgaccc cgaggcgctc gtcccagcca agatggagta     5160

gcccttagca gtgatgggta gcaccagatg tagtttcgaa cttggagaac tgtacacatg     5220

caatcttcca catttttagg cagagaagta taggcctgtc tgtcggccct ggcctggcct     5280

cgagtctcta ccagcattaa ctgtctagag aggggacctc ctgggagcac catccacctc     5340

cccaggcccc agtcactgta gctcagtgga tgcatgcgcg tgccggccgc tccttgtact     5400

gtatcttact ggacagggcc agctctccag gaggctcaca ggcccagcgg gtatgtcagt     5460

gtcactggag tcagacagta ataaattaaa gcaatgacaa gccaccactg gctccctgga     5520

ctccttgctg tcagcagtgg ctccggggcc acagagaaga aagaaagact tttaggaact     5580

gggtctaact tatgggcaaa gtacttgcct tgccaggtgt atgggttttg cattcccatc     5640

acccacacac cctaaacaag ccaagtcagt gagcttcaag ttagagcctc cacctcaatg     5700

tgtacgtgga aagcaatcaa agatgatgcc tagcatccac ctctggccct catgtgcaga     5760

tgtacacaca ctgaattaca tacacgggac acacacatcc acacggaggc agtccatgac     5820

ttgcactggg gagatggtac cataggcgaa agtgccacag gcacagggcc aggctaattt     5880

agtcctgcag tcctgtgctc ttaagatgaa ggcacaaaga ggaaccccag gcgctccaac     5940

tagcatgcca ggcagtgaca agaccctgct tcaaatgaat cagagcccac attcagtatt     6000

gccctcttac ccgatgcgat gcccatgccc tcacatatga atgtgtatat atacatacat     6060

acgtaaaata attctttttt aaattataga catttttgtg tgaatgtttt gcctgaatgt     6120

gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtatcaagta cattcctaga     6180

gcctacagag gtcaagggag ggcattggat ctggaactgg agtcacatga ggctgtgagc     6240

aactgtgtgg gttcctgggc ctttgcaaca gcagttagta ctcttcacca ctgagccatt     6300

tctccaatct caaaaagaag cattctttta aatgaagact gaaataaata agtaggactt     6360

gccttgg                                                               6367


<210> 207
<211> 1614
<212> PRT
<213> Mus musculus

<400> 207
Met Ser Thr Pro Asp Pro Pro Leu Gly Gly Thr Pro Arg Pro Gly Pro 
1               5                   10                  15      


Ser Pro Gly Pro Gly Pro Ser Pro Gly Ala Met Leu Gly Pro Ser Pro 
            20                  25                  30          


Gly Pro Ser Pro Gly Ser Ala His Ser Met Met Gly Pro Ser Pro Gly 
        35                  40                  45              


Pro Pro Ser Ala Gly His Pro Met Pro Thr Gln Gly Pro Gly Gly Tyr 
    50                  55                  60                  


Pro Gln Asp Asn Met His Gln Met His Lys Pro Met Glu Ser Met His 
65                  70                  75                  80  


Glu Lys Gly Met Pro Asp Asp Pro Arg Tyr Asn Gln Met Lys Gly Met 
                85                  90                  95      


Gly Met Arg Ser Gly Ala His Thr Gly Met Ala Pro Pro Pro Ser Pro 
            100                 105                 110         


Met Asp Gln His Ser Gln Gly Tyr Pro Ser Pro Leu Gly Gly Ser Glu 
        115                 120                 125             


His Ala Ser Ser Pro Val Pro Ala Ser Gly Pro Ser Ser Gly Pro Gln 
    130                 135                 140                 


Met Ser Ser Gly Pro Gly Gly Ala Pro Leu Asp Gly Ser Asp Pro Gln 
145                 150                 155                 160 


Ala Leu Gly Gln Gln Asn Arg Gly Pro Thr Pro Phe Asn Gln Asn Gln 
                165                 170                 175     


Leu His Gln Leu Arg Ala Gln Ile Met Ala Tyr Lys Met Leu Ala Arg 
            180                 185                 190         


Gly Gln Pro Leu Pro Asp His Leu Gln Met Ala Val Gln Gly Lys Arg 
        195                 200                 205             


Pro Met Pro Gly Met Gln Gln Gln Met Pro Thr Leu Pro Pro Pro Ser 
    210                 215                 220                 


Val Ser Ala Thr Gly Pro Gly Pro Gly Pro Gly Pro Gly Pro Gly Pro 
225                 230                 235                 240 


Gly Pro Gly Pro Ala Pro Pro Asn Tyr Ser Arg Pro His Gly Met Gly 
                245                 250                 255     


Gly Pro Asn Met Pro Pro Pro Gly Pro Ser Gly Val Pro Pro Gly Met 
            260                 265                 270         


Pro Gly Gln Pro Pro Gly Gly Pro Pro Lys Pro Trp Pro Glu Gly Pro 
        275                 280                 285             


Met Ala Asn Ala Ala Ala Pro Thr Ser Thr Pro Gln Lys Leu Ile Pro 
    290                 295                 300                 


Pro Gln Pro Thr Gly Arg Pro Ser Pro Ala Pro Pro Ala Val Pro Pro 
305                 310                 315                 320 


Ala Ala Ser Pro Val Met Pro Pro Gln Thr Gln Ser Pro Gly Gln Pro 
                325                 330                 335     


Ala Gln Pro Ala Pro Leu Val Pro Leu His Gln Lys Gln Ser Arg Ile 
            340                 345                 350         


Thr Pro Ile Gln Lys Pro Arg Gly Leu Asp Pro Val Glu Ile Leu Gln 
        355                 360                 365             


Glu Arg Glu Tyr Arg Leu Gln Ala Arg Ile Ala His Arg Ile Gln Glu 
    370                 375                 380                 


Leu Glu Asn Leu Pro Gly Ser Leu Ala Gly Asp Leu Arg Thr Lys Ala 
385                 390                 395                 400 


Thr Ile Glu Leu Lys Ala Leu Arg Leu Leu Asn Phe Gln Arg Gln Leu 
                405                 410                 415     


Arg Gln Glu Val Val Val Cys Met Arg Arg Asp Thr Ala Leu Glu Thr 
            420                 425                 430         


Ala Leu Asn Ala Lys Ala Tyr Lys Arg Ser Lys Arg Gln Ser Leu Arg 
        435                 440                 445             


Glu Ala Arg Ile Thr Glu Lys Leu Glu Lys Gln Gln Lys Ile Glu Gln 
    450                 455                 460                 


Glu Arg Lys Arg Arg Gln Lys His Gln Glu Tyr Leu Asn Ser Ile Leu 
465                 470                 475                 480 


Gln His Ala Lys Asp Phe Arg Glu Tyr His Arg Ser Val Thr Gly Lys 
                485                 490                 495     


Leu Gln Lys Leu Thr Lys Ala Val Ala Thr Tyr His Ala Asn Thr Glu 
            500                 505                 510         


Arg Glu Gln Lys Lys Glu Asn Glu Arg Ile Glu Lys Glu Arg Met Arg 
        515                 520                 525             


Arg Leu Met Ala Glu Asp Glu Glu Gly Tyr Arg Lys Leu Ile Asp Gln 
    530                 535                 540                 


Lys Lys Asp Lys Arg Leu Ala Tyr Leu Leu Gln Gln Thr Asp Glu Tyr 
545                 550                 555                 560 


Val Ala Asn Leu Thr Glu Leu Val Arg Gln His Lys Ala Ala Gln Val 
                565                 570                 575     


Ala Lys Glu Lys Lys Lys Lys Lys Lys Lys Lys Lys Ala Glu Asn Ala 
            580                 585                 590         


Glu Gly Gln Thr Pro Ala Ile Gly Pro Asp Gly Glu Pro Leu Asp Glu 
        595                 600                 605             


Thr Ser Gln Met Ser Asp Leu Pro Val Lys Val Ile His Val Glu Ser 
    610                 615                 620                 


Gly Lys Ile Leu Thr Gly Thr Asp Ala Pro Lys Ala Gly Gln Leu Glu 
625                 630                 635                 640 


Ala Trp Leu Glu Met Asn Pro Gly Tyr Glu Val Ala Pro Arg Ser Asp 
                645                 650                 655     


Ser Glu Glu Ser Gly Ser Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu 
            660                 665                 670         


Gln Pro Gln Pro Ala Gln Pro Pro Thr Leu Pro Val Glu Glu Lys Lys 
        675                 680                 685             


Lys Ile Pro Asp Pro Asp Ser Asp Asp Val Ser Glu Val Asp Ala Arg 
    690                 695                 700                 


His Ile Ile Glu Asn Ala Lys Gln Asp Val Asp Asp Glu Tyr Gly Val 
705                 710                 715                 720 


Ser Gln Ala Leu Ala Arg Gly Leu Gln Ser Tyr Tyr Ala Val Ala His 
                725                 730                 735     


Ala Val Thr Glu Arg Val Asp Lys Gln Ser Ala Leu Met Val Asn Gly 
            740                 745                 750         


Val Leu Lys Gln Tyr Gln Ile Lys Gly Leu Glu Trp Leu Val Ser Leu 
        755                 760                 765             


Tyr Asn Asn Asn Leu Asn Gly Ile Leu Ala Asp Glu Met Gly Leu Gly 
    770                 775                 780                 


Lys Thr Ile Gln Thr Ile Ala Leu Ile Thr Tyr Leu Met Glu His Lys 
785                 790                 795                 800 


Arg Ile Asn Gly Pro Phe Leu Ile Ile Val Pro Leu Ser Thr Leu Ser 
                805                 810                 815     


Asn Trp Ala Tyr Glu Phe Asp Lys Trp Ala Pro Ser Val Val Lys Val 
            820                 825                 830         


Ser Tyr Lys Gly Ser Pro Ala Ala Arg Arg Ala Phe Val Pro Gln Leu 
        835                 840                 845             


Arg Ser Gly Lys Phe Asn Val Leu Leu Thr Thr Tyr Glu Tyr Ile Ile 
    850                 855                 860                 


Lys Asp Lys His Ile Leu Ala Lys Ile Arg Trp Lys Tyr Met Ile Val 
865                 870                 875                 880 


Asp Glu Gly His Arg Met Lys Asn His His Cys Lys Leu Thr Gln Val 
                885                 890                 895     


Leu Asn Thr His Tyr Val Ala Pro Arg Arg Leu Leu Leu Thr Gly Thr 
            900                 905                 910         


Pro Leu Gln Asn Lys Leu Pro Glu Leu Trp Ala Leu Leu Asn Phe Leu 
        915                 920                 925             


Leu Pro Thr Ile Phe Lys Ser Cys Ser Thr Phe Glu Gln Trp Phe Asn 
    930                 935                 940                 


Ala Pro Phe Ala Met Thr Gly Glu Lys Val Asp Leu Asn Glu Glu Glu 
945                 950                 955                 960 


Thr Ile Leu Ile Ile Arg Arg Leu His Lys Val Leu Arg Pro Phe Leu 
                965                 970                 975     


Leu Arg Arg Leu Lys Lys Glu Val Glu Ala Gln Leu Pro Glu Lys Val 
            980                 985                 990         


Glu Tyr Val Ile Lys Cys Asp Met  Ser Ala Leu Gln Arg  Val Leu Tyr 
        995                 1000                 1005             


Arg His  Met Gln Ala Lys Gly  Val Leu Leu Thr Asp  Gly Ser Glu 
    1010                 1015                 1020             


Lys Asp  Lys Lys Gly Lys Gly  Gly Thr Lys Thr Leu  Met Asn Thr 
    1025                 1030                 1035             


Ile Met  Gln Leu Arg Lys Ile  Cys Asn His Pro Tyr  Met Phe Gln 
    1040                 1045                 1050             


His Ile  Glu Glu Ser Phe Ser  Glu His Leu Gly Phe  Thr Gly Gly 
    1055                 1060                 1065             


Ile Val  Gln Gly Leu Asp Leu  Tyr Arg Ala Ser Gly  Lys Phe Glu 
    1070                 1075                 1080             


Leu Leu  Asp Arg Ile Leu Pro  Lys Leu Arg Ala Thr  Asn His Lys 
    1085                 1090                 1095             


Val Leu  Leu Phe Cys Gln Met  Thr Ser Leu Met Thr  Ile Met Glu 
    1100                 1105                 1110             


Asp Tyr  Phe Ala Tyr Arg Gly  Phe Lys Tyr Leu Arg  Leu Asp Gly 
    1115                 1120                 1125             


Thr Thr  Lys Ala Glu Asp Arg  Gly Met Leu Leu Lys  Thr Phe Asn 
    1130                 1135                 1140             


Glu Pro  Gly Ser Glu Tyr Phe  Ile Phe Leu Leu Ser  Thr Arg Ala 
    1145                 1150                 1155             


Gly Gly  Leu Gly Leu Asn Leu  Gln Ser Ala Asp Thr  Val Ile Ile 
    1160                 1165                 1170             


Phe Asp  Ser Asp Trp Asn Pro  His Gln Asp Leu Gln  Ala Gln Asp 
    1175                 1180                 1185             


Arg Ala  His Arg Ile Gly Gln  Gln Asn Glu Val Arg  Val Leu Arg 
    1190                 1195                 1200             


Leu Cys  Thr Val Asn Ser Val  Glu Glu Lys Ile Leu  Ala Ala Ala 
    1205                 1210                 1215             


Lys Tyr  Lys Leu Asn Val Asp  Gln Lys Val Ile Gln  Ala Gly Met 
    1220                 1225                 1230             


Phe Asp  Gln Lys Ser Ser Ser  His Glu Arg Arg Ala  Phe Leu Gln 
    1235                 1240                 1245             


Ala Ile  Leu Glu His Glu Glu  Gln Asp Glu Glu Glu  Asp Glu Val 
    1250                 1255                 1260             


Pro Asp  Asp Glu Thr Val Asn  Gln Met Ile Ala Arg  His Glu Glu 
    1265                 1270                 1275             


Glu Phe  Asp Leu Phe Met Arg  Met Asp Leu Asp Arg  Arg Arg Glu 
    1280                 1285                 1290             


Glu Ala  Arg Asn Pro Lys Arg  Lys Pro Arg Leu Met  Glu Glu Asp 
    1295                 1300                 1305             


Glu Leu  Pro Ser Trp Ile Ile  Lys Asp Asp Ala Glu  Val Glu Arg 
    1310                 1315                 1320             


Leu Thr  Cys Glu Glu Glu Glu  Glu Lys Met Phe Gly  Arg Gly Ser 
    1325                 1330                 1335             


Arg His  Arg Lys Glu Val Asp  Tyr Ser Asp Ser Leu  Thr Glu Lys 
    1340                 1345                 1350             


Gln Trp  Leu Lys Ala Ile Glu  Glu Gly Thr Leu Glu  Glu Ile Glu 
    1355                 1360                 1365             


Glu Glu  Val Arg Gln Lys Lys  Ser Ser Arg Lys Arg  Lys Arg Asp 
    1370                 1375                 1380             


Ser Glu  Ala Gly Ser Ser Thr  Pro Thr Thr Ser Thr  Arg Ser Arg 
    1385                 1390                 1395             


Asp Lys  Asp Glu Glu Ser Lys  Lys Gln Lys Lys Arg  Gly Arg Pro 
    1400                 1405                 1410             


Pro Ala  Glu Lys Leu Ser Pro  Asn Pro Pro Asn Leu  Thr Lys Lys 
    1415                 1420                 1425             


Met Lys  Lys Ile Val Asp Ala  Val Ile Lys Tyr Lys  Asp Ser Ser 
    1430                 1435                 1440             


Ser Gly  Arg Gln Leu Ser Glu  Val Phe Ile Gln Leu  Pro Ser Arg 
    1445                 1450                 1455             


Lys Glu  Leu Pro Glu Tyr Tyr  Glu Leu Ile Arg Lys  Pro Val Asp 
    1460                 1465                 1470             


Phe Lys  Lys Ile Lys Glu Arg  Ile Arg Asn His Lys  Tyr Arg Ser 
    1475                 1480                 1485             


Leu Asn  Asp Leu Glu Lys Asp  Val Met Leu Leu Cys  Gln Asn Ala 
    1490                 1495                 1500             


Gln Thr  Phe Asn Leu Glu Gly  Ser Leu Ile Tyr Glu  Asp Ser Ile 
    1505                 1510                 1515             


Val Leu  Gln Ser Val Phe Thr  Ser Val Arg Gln Lys  Ile Glu Lys 
    1520                 1525                 1530             


Glu Asp  Asp Ser Glu Gly Glu  Glu Ser Glu Glu Glu  Glu Glu Gly 
    1535                 1540                 1545             


Glu Glu  Glu Gly Ser Glu Ser  Glu Ser Arg Ser Val  Lys Val Lys 
    1550                 1555                 1560             


Ile Lys  Leu Gly Arg Lys Glu  Lys Ala Gln Asp Arg  Leu Lys Gly 
    1565                 1570                 1575             


Gly Arg  Arg Arg Pro Ser Arg  Gly Ser Arg Ala Lys  Pro Val Val 
    1580                 1585                 1590             


Ser Asp  Asp Asp Ser Glu Glu  Glu Gln Glu Glu Asp  Arg Ser Gly 
    1595                 1600                 1605             


Ser Gly  Ser Glu Glu Asp 
    1610                 


<210> 208
<211> 6364
<212> DNA
<213> Mus musculus

<400> 208
ggcaagtgga gcgggtagac agggaggcgg gggcgcgcgg cgggcgcgtg cggtgggggg       60

gggtggcctg gcgaagccca gcgggcgcgc gcgcgaggct ttcccactcg cttggcagcg      120

gcggagacgg cttctttgtt tcctgaggag aagcgagacg cccactctgt ccccgacccc      180

tcgtggaggg ttgggggcgg cgccaggaag gttacggcgc cgttacctcc aggagaccag      240

tgcctgtagc tccagtaaag atgtctactc cagacccacc cttgggtggg actcctcggc      300

ctggtccttc cccaggccct ggtccttcac ctggtgcaat gctgggtcct agccctggcc      360

cctcaccagg ttctgcccac agcatgatgg ggccaagccc aggacctcct tcagcaggac      420

atcccatgcc cacccagggg cctggagggt acccccagga caacatgcat cagatgcaca      480

agcctatgga gtccatgcac gagaagggca tgcctgatga cccacgatac aaccagatga      540

aagggatggg catgcggtca ggggcccaca caggcatggc acctccacct agtcccatgg      600

accagcattc tcaaggttac ccctcacccc tcggcggctc tgaacatgcc tccagtcctg      660

tcccagccag tggcccatct tcaggccccc agatgtcctc tgggccagga ggggccccac      720

tagatggttc tgatccccag gccttgggac agcaaaacag aggcccaacc ccatttaacc      780

agaaccagct gcatcaactc agagctcaga taatggccta caagatgttg gccaggggcc      840

agccattgcc cgaccacctg cagatggccg tgcaaggcaa gcggccgatg cctggaatgc      900

agcaacagat gccaacacta cctccaccct cagtgtccgc cacaggaccc ggacctggac      960

ccggccctgg ccctggccct ggcccaggac cagcccctcc aaattacagt agaccccatg     1020

gtatgggagg gcccaacatg cctcccccag gaccctcagg tgtgcccccc gggatgcctg     1080

gtcagccgcc tggagggcct cccaagccat ggcctgaagg acccatggcc aatgctgctg     1140

cccccacaag caccccacag aagctgattc ctccgcaacc aacaggccgt ccttcacctg     1200

cacctcctgc tgtcccgcct gctgcctcac ctgtaatgcc accacaaaca cagtccccag     1260

ggcagccagc ccagcctgct ccattggtgc cactgcacca gaagcagagc cgaatcaccc     1320

ccatccagaa gccccgaggc cttgaccctg tggagatcct acaagagcgg gagtacaggc     1380

ttcaggctcg aatcgcacac agaattcagg aacttgaaaa cctccctggg tccctggctg     1440

gggaccttcg aaccaaagca accatcgaac tcaaggccct taggttgctg aacttccaga     1500

ggcagctgcg ccaggaggtg gtggtgtgca tgcgaagaga cacagccctg gagacagccc     1560

tcaatgccaa ggcctacaag cgcagcaaac gtcagtcact acgggaggcc cgcatcactg     1620

agaagttgga gaagcagcag aagattgaac aggagcgcaa gcgccgccag aagcaccagg     1680

agtacctcaa cagcattctg cagcatgcca aggacttcag ggagtatcac agatcagtca     1740

caggcaaact ccagaaactc accaaggctg tggccaccta ccatgccaac actgagcggg     1800

agcagaagaa agaaaatgag cgcattgaga aggagcgaat gcggaggctt atggctgaag     1860

atgaggaggg ctaccgcaaa ctcattgacc agaagaagga caagcgcctg gcctaccttc     1920

tgcagcagac agatgagtat gtggccaacc tcacagagct ggtgcggcag cacaaagctg     1980

cccaggttgc caaggagaag aagaagaaaa agaaaaagaa gaaggcagaa aatgctgaag     2040

gacagacacc tgctattgga ccagatggtg agcctctgga tgagaccagc cagatgagtg     2100

acctccctgt gaaggtgatc cacgtggaga gtggcaagat cctcactggc acagatgccc     2160

caaaagccgg gcagctggaa gcctggcttg aaatgaaccc agggtatgaa gtagccccca     2220

ggtcagacag tgaagaaagt ggctctgaag aggaggagga ggaggaggaa gaggagcagc     2280

ctcagcccgc acagccccct acactgcctg tggaagaaaa gaagaagatt ccagacccag     2340

acagcgatga tgtctctgag gtggacgccc gacacattat tgagaacgcc aagcaagatg     2400

tggacgatga gtacggtgtg tcccaggccc ttgctcgtgg cctgcagtct tactatgctg     2460

tggcccatgc agtcacagag agagtagata agcagtccgc cctcatggtc aacggtgtcc     2520

tcaaacagta ccagatcaag ggtttggagt ggctggtgtc cctgtacaac aacaacctga     2580

atggcatcct ggctgatgag atggggctgg ggaagaccat ccagaccatc gcgctcatca     2640

catacctcat ggagcacaag cgcatcaacg ggcctttcct catcatcgtg cctctctcga     2700

cactgtcaaa ctgggcgtat gaatttgaca agtgggcccc ctctgtggtg aaggtttctt     2760

acaagggctc tccagctgca aggcgagctt ttgtcccaca gcttcgcagt gggaagttca     2820

acgtcttact gaccacctat gaatatatca tcaaagacaa gcatatccta gccaagatcc     2880

gctggaagta catgattgtg gatgaaggcc accgcatgaa aaaccaccac tgcaagttga     2940

cgcaggtcct taacacacac tacgtggccc ctcggcgcct gcttcttaca ggcacaccac     3000

tgcagaacaa gctaccggag ctctgggccc tgcttaactt cctgctcccc actatcttca     3060

agagctgcag caccttcgaa cagtggttca atgcaccctt tgccatgact ggagaaaagg     3120

tggacctgaa tgaagaggag actatcctca ttattcgtcg cctacacaaa gttctgcggc     3180

ccttcctgct gcggcggctc aagaaggaag ttgaagccca gctccctgag aaggtagagt     3240

atgtcatcaa atgcgacatg tcagccctgc agcgtgtgct gtaccgtcac atgcaggcca     3300

aaggtgtgct gctgactgac ggctccgaga aggacaagaa gggcaaaggt ggcaccaaga     3360

cactgatgaa cactattatg caactgcgta agatctgcaa ccacccctac atgttccagc     3420

acatcgagga gtccttttct gagcacttgg ggttcaccgg cggcatcgtg caaggattgg     3480

acctttaccg tgcctcaggg aaatttgaac ttcttgatag aattctaccc aaactccgtg     3540

caacgaacca taaagtgctc ctcttttgcc aaatgacctc cctcatgacc atcatggaag     3600

actactttgc ataccgtggc ttcaaatacc tcaggcttga tggaaccaca aaagcagaag     3660

accggggcat gctgttgaaa acctttaatg aacctggctc tgagtatttc attttcctgc     3720

tcagtacccg tgctgggggg ctgggcctga atctgcagtc agctgacact gtgatcatct     3780

ttgacagtga ctggaatccc caccaggacc tgcaagcaca ggatcgagcc catcgcattg     3840

gacagcagaa tgaggtgcgt gttcttcgcc tgtgcacggt caacagtgtg gaagagaaga     3900

tactggctgc tgccaaatac aaactcaatg tggatcagaa ggtgatccag gcaggcatgt     3960

tcgaccagaa gtcgtccagc catgagaggc gtgccttcct gcaggccatc ctggagcacg     4020

aggagcagga tgaggaggaa gatgaggtgc ctgatgatga gaccgtcaac cagatgattg     4080

cccggcacga agaagagttt gacctcttca tgcgcatgga cttggaccgc cggcgtgaag     4140

aagcccgcaa ccccaagcgg aagccacgcc tgatggaaga ggatgagctc ccatcctgga     4200

tcatcaagga tgatgccgag gtggagcggc tgacatgtga agaggaagag gagaagatgt     4260

tcggccgtgg ttctcgccac cgcaaggagg tagactacag cgactcactg acagagaagc     4320

agtggctcaa ggctatcgag gagggcacgc tggaggagat cgaagaggag gtccggcaga     4380

agaaatcttc acgtaagcgt aagcgagaca gcgaggccgg ctcctccacc ccgaccacca     4440

gcacccgcag ccgtgacaag gatgaggaga gcaagaagca gaagaaacgt gggcggccac     4500

ctgctgagaa gctgtcccca aacccaccta acctcaccaa gaagatgaag aagatcgtgg     4560

atgctgtgat caagtacaaa gacagcagtg gacgtcagct cagcgaggtg ttcatccagc     4620

tcccctctcg caaggagctt cctgagtact atgagctcat ccgaaagcct gtggacttca     4680

agaagatcaa ggaacgcatc cgaaaccaca agtaccgcag cctcaatgac ctggagaagg     4740

atgtgatgct gctgtgccag aacgctcaga cgttcaacct cgagggttcc ctgatctatg     4800

aggactccat cgtcctgcag tctgtcttca ccagcgtacg gcagaagatt gagaaggagg     4860

acgacagtga aggcgaggaa agcgaggagg aggaggaggg cgaggaggaa ggctccgagt     4920

ctgagtcccg ctccgtcaag gtgaagatca agctgggccg caaggagaag gcccaggacc     4980

gactcaaggg gggccgccgg cggccaagcc ggggatcccg ggccaagccg gttgtgagtg     5040

acgatgacag tgaggaggag caggaggagg accgctcagg aagtggcagt gaggaagact     5100

gaaccagaca ttcctgagtc ctgaccccga ggcgctcgtc ccagccaaga tggagtagcc     5160

cttagcagtg atgggtagca ccagatgtag tttcgaactt ggagaactgt acacatgcaa     5220

tcttccacat ttttaggcag agaagtatag gcctgtctgt cggccctggc ctggcctcga     5280

gtctctacca gcattaactg tctagagagg ggacctcctg ggagcaccat ccacctcccc     5340

aggccccagt cactgtagct cagtggatgc atgcgcgtgc cggccgctcc ttgtactgta     5400

tcttactgga cagggccagc tctccaggag gctcacaggc ccagcgggta tgtcagtgtc     5460

actggagtca gacagtaata aattaaagca atgacaagcc accactggct ccctggactc     5520

cttgctgtca gcagtggctc cggggccaca gagaagaaag aaagactttt aggaactggg     5580

tctaacttat gggcaaagta cttgccttgc caggtgtatg ggttttgcat tcccatcacc     5640

cacacaccct aaacaagcca agtcagtgag cttcaagtta gagcctccac ctcaatgtgt     5700

acgtggaaag caatcaaaga tgatgcctag catccacctc tggccctcat gtgcagatgt     5760

acacacactg aattacatac acgggacaca cacatccaca cggaggcagt ccatgacttg     5820

cactggggag atggtaccat aggcgaaagt gccacaggca cagggccagg ctaatttagt     5880

cctgcagtcc tgtgctctta agatgaaggc acaaagagga accccaggcg ctccaactag     5940

catgccaggc agtgacaaga ccctgcttca aatgaatcag agcccacatt cagtattgcc     6000

ctcttacccg atgcgatgcc catgccctca catatgaatg tgtatatata catacatacg     6060

taaaataatt cttttttaaa ttatagacat ttttgtgtga atgttttgcc tgaatgtgtg     6120

tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgta tcaagtacat tcctagagcc     6180

tacagaggtc aagggagggc attggatctg gaactggagt cacatgaggc tgtgagcaac     6240

tgtgtgggtt cctgggcctt tgcaacagca gttagtactc ttcaccactg agccatttct     6300

ccaatctcaa aaagaagcat tcttttaaat gaagactgaa ataaataagt aggacttgcc     6360

ttgg                                                                  6364


<210> 209
<211> 1613
<212> PRT
<213> Mus musculus

<400> 209
Met Ser Thr Pro Asp Pro Pro Leu Gly Gly Thr Pro Arg Pro Gly Pro 
1               5                   10                  15      


Ser Pro Gly Pro Gly Pro Ser Pro Gly Ala Met Leu Gly Pro Ser Pro 
            20                  25                  30          


Gly Pro Ser Pro Gly Ser Ala His Ser Met Met Gly Pro Ser Pro Gly 
        35                  40                  45              


Pro Pro Ser Ala Gly His Pro Met Pro Thr Gln Gly Pro Gly Gly Tyr 
    50                  55                  60                  


Pro Gln Asp Asn Met His Gln Met His Lys Pro Met Glu Ser Met His 
65                  70                  75                  80  


Glu Lys Gly Met Pro Asp Asp Pro Arg Tyr Asn Gln Met Lys Gly Met 
                85                  90                  95      


Gly Met Arg Ser Gly Ala His Thr Gly Met Ala Pro Pro Pro Ser Pro 
            100                 105                 110         


Met Asp Gln His Ser Gln Gly Tyr Pro Ser Pro Leu Gly Gly Ser Glu 
        115                 120                 125             


His Ala Ser Ser Pro Val Pro Ala Ser Gly Pro Ser Ser Gly Pro Gln 
    130                 135                 140                 


Met Ser Ser Gly Pro Gly Gly Ala Pro Leu Asp Gly Ser Asp Pro Gln 
145                 150                 155                 160 


Ala Leu Gly Gln Gln Asn Arg Gly Pro Thr Pro Phe Asn Gln Asn Gln 
                165                 170                 175     


Leu His Gln Leu Arg Ala Gln Ile Met Ala Tyr Lys Met Leu Ala Arg 
            180                 185                 190         


Gly Gln Pro Leu Pro Asp His Leu Gln Met Ala Val Gln Gly Lys Arg 
        195                 200                 205             


Pro Met Pro Gly Met Gln Gln Gln Met Pro Thr Leu Pro Pro Pro Ser 
    210                 215                 220                 


Val Ser Ala Thr Gly Pro Gly Pro Gly Pro Gly Pro Gly Pro Gly Pro 
225                 230                 235                 240 


Gly Pro Gly Pro Ala Pro Pro Asn Tyr Ser Arg Pro His Gly Met Gly 
                245                 250                 255     


Gly Pro Asn Met Pro Pro Pro Gly Pro Ser Gly Val Pro Pro Gly Met 
            260                 265                 270         


Pro Gly Gln Pro Pro Gly Gly Pro Pro Lys Pro Trp Pro Glu Gly Pro 
        275                 280                 285             


Met Ala Asn Ala Ala Ala Pro Thr Ser Thr Pro Gln Lys Leu Ile Pro 
    290                 295                 300                 


Pro Gln Pro Thr Gly Arg Pro Ser Pro Ala Pro Pro Ala Val Pro Pro 
305                 310                 315                 320 


Ala Ala Ser Pro Val Met Pro Pro Gln Thr Gln Ser Pro Gly Gln Pro 
                325                 330                 335     


Ala Gln Pro Ala Pro Leu Val Pro Leu His Gln Lys Gln Ser Arg Ile 
            340                 345                 350         


Thr Pro Ile Gln Lys Pro Arg Gly Leu Asp Pro Val Glu Ile Leu Gln 
        355                 360                 365             


Glu Arg Glu Tyr Arg Leu Gln Ala Arg Ile Ala His Arg Ile Gln Glu 
    370                 375                 380                 


Leu Glu Asn Leu Pro Gly Ser Leu Ala Gly Asp Leu Arg Thr Lys Ala 
385                 390                 395                 400 


Thr Ile Glu Leu Lys Ala Leu Arg Leu Leu Asn Phe Gln Arg Gln Leu 
                405                 410                 415     


Arg Gln Glu Val Val Val Cys Met Arg Arg Asp Thr Ala Leu Glu Thr 
            420                 425                 430         


Ala Leu Asn Ala Lys Ala Tyr Lys Arg Ser Lys Arg Gln Ser Leu Arg 
        435                 440                 445             


Glu Ala Arg Ile Thr Glu Lys Leu Glu Lys Gln Gln Lys Ile Glu Gln 
    450                 455                 460                 


Glu Arg Lys Arg Arg Gln Lys His Gln Glu Tyr Leu Asn Ser Ile Leu 
465                 470                 475                 480 


Gln His Ala Lys Asp Phe Arg Glu Tyr His Arg Ser Val Thr Gly Lys 
                485                 490                 495     


Leu Gln Lys Leu Thr Lys Ala Val Ala Thr Tyr His Ala Asn Thr Glu 
            500                 505                 510         


Arg Glu Gln Lys Lys Glu Asn Glu Arg Ile Glu Lys Glu Arg Met Arg 
        515                 520                 525             


Arg Leu Met Ala Glu Asp Glu Glu Gly Tyr Arg Lys Leu Ile Asp Gln 
    530                 535                 540                 


Lys Lys Asp Lys Arg Leu Ala Tyr Leu Leu Gln Gln Thr Asp Glu Tyr 
545                 550                 555                 560 


Val Ala Asn Leu Thr Glu Leu Val Arg Gln His Lys Ala Ala Gln Val 
                565                 570                 575     


Ala Lys Glu Lys Lys Lys Lys Lys Lys Lys Lys Lys Ala Glu Asn Ala 
            580                 585                 590         


Glu Gly Gln Thr Pro Ala Ile Gly Pro Asp Gly Glu Pro Leu Asp Glu 
        595                 600                 605             


Thr Ser Gln Met Ser Asp Leu Pro Val Lys Val Ile His Val Glu Ser 
    610                 615                 620                 


Gly Lys Ile Leu Thr Gly Thr Asp Ala Pro Lys Ala Gly Gln Leu Glu 
625                 630                 635                 640 


Ala Trp Leu Glu Met Asn Pro Gly Tyr Glu Val Ala Pro Arg Ser Asp 
                645                 650                 655     


Ser Glu Glu Ser Gly Ser Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu 
            660                 665                 670         


Gln Pro Gln Pro Ala Gln Pro Pro Thr Leu Pro Val Glu Glu Lys Lys 
        675                 680                 685             


Lys Ile Pro Asp Pro Asp Ser Asp Asp Val Ser Glu Val Asp Ala Arg 
    690                 695                 700                 


His Ile Ile Glu Asn Ala Lys Gln Asp Val Asp Asp Glu Tyr Gly Val 
705                 710                 715                 720 


Ser Gln Ala Leu Ala Arg Gly Leu Gln Ser Tyr Tyr Ala Val Ala His 
                725                 730                 735     


Ala Val Thr Glu Arg Val Asp Lys Gln Ser Ala Leu Met Val Asn Gly 
            740                 745                 750         


Val Leu Lys Gln Tyr Gln Ile Lys Gly Leu Glu Trp Leu Val Ser Leu 
        755                 760                 765             


Tyr Asn Asn Asn Leu Asn Gly Ile Leu Ala Asp Glu Met Gly Leu Gly 
    770                 775                 780                 


Lys Thr Ile Gln Thr Ile Ala Leu Ile Thr Tyr Leu Met Glu His Lys 
785                 790                 795                 800 


Arg Ile Asn Gly Pro Phe Leu Ile Ile Val Pro Leu Ser Thr Leu Ser 
                805                 810                 815     


Asn Trp Ala Tyr Glu Phe Asp Lys Trp Ala Pro Ser Val Val Lys Val 
            820                 825                 830         


Ser Tyr Lys Gly Ser Pro Ala Ala Arg Arg Ala Phe Val Pro Gln Leu 
        835                 840                 845             


Arg Ser Gly Lys Phe Asn Val Leu Leu Thr Thr Tyr Glu Tyr Ile Ile 
    850                 855                 860                 


Lys Asp Lys His Ile Leu Ala Lys Ile Arg Trp Lys Tyr Met Ile Val 
865                 870                 875                 880 


Asp Glu Gly His Arg Met Lys Asn His His Cys Lys Leu Thr Gln Val 
                885                 890                 895     


Leu Asn Thr His Tyr Val Ala Pro Arg Arg Leu Leu Leu Thr Gly Thr 
            900                 905                 910         


Pro Leu Gln Asn Lys Leu Pro Glu Leu Trp Ala Leu Leu Asn Phe Leu 
        915                 920                 925             


Leu Pro Thr Ile Phe Lys Ser Cys Ser Thr Phe Glu Gln Trp Phe Asn 
    930                 935                 940                 


Ala Pro Phe Ala Met Thr Gly Glu Lys Val Asp Leu Asn Glu Glu Glu 
945                 950                 955                 960 


Thr Ile Leu Ile Ile Arg Arg Leu His Lys Val Leu Arg Pro Phe Leu 
                965                 970                 975     


Leu Arg Arg Leu Lys Lys Glu Val Glu Ala Gln Leu Pro Glu Lys Val 
            980                 985                 990         


Glu Tyr Val Ile Lys Cys Asp Met  Ser Ala Leu Gln Arg  Val Leu Tyr 
        995                 1000                 1005             


Arg His  Met Gln Ala Lys Gly  Val Leu Leu Thr Asp  Gly Ser Glu 
    1010                 1015                 1020             


Lys Asp  Lys Lys Gly Lys Gly  Gly Thr Lys Thr Leu  Met Asn Thr 
    1025                 1030                 1035             


Ile Met  Gln Leu Arg Lys Ile  Cys Asn His Pro Tyr  Met Phe Gln 
    1040                 1045                 1050             


His Ile  Glu Glu Ser Phe Ser  Glu His Leu Gly Phe  Thr Gly Gly 
    1055                 1060                 1065             


Ile Val  Gln Gly Leu Asp Leu  Tyr Arg Ala Ser Gly  Lys Phe Glu 
    1070                 1075                 1080             


Leu Leu  Asp Arg Ile Leu Pro  Lys Leu Arg Ala Thr  Asn His Lys 
    1085                 1090                 1095             


Val Leu  Leu Phe Cys Gln Met  Thr Ser Leu Met Thr  Ile Met Glu 
    1100                 1105                 1110             


Asp Tyr  Phe Ala Tyr Arg Gly  Phe Lys Tyr Leu Arg  Leu Asp Gly 
    1115                 1120                 1125             


Thr Thr  Lys Ala Glu Asp Arg  Gly Met Leu Leu Lys  Thr Phe Asn 
    1130                 1135                 1140             


Glu Pro  Gly Ser Glu Tyr Phe  Ile Phe Leu Leu Ser  Thr Arg Ala 
    1145                 1150                 1155             


Gly Gly  Leu Gly Leu Asn Leu  Gln Ser Ala Asp Thr  Val Ile Ile 
    1160                 1165                 1170             


Phe Asp  Ser Asp Trp Asn Pro  His Gln Asp Leu Gln  Ala Gln Asp 
    1175                 1180                 1185             


Arg Ala  His Arg Ile Gly Gln  Gln Asn Glu Val Arg  Val Leu Arg 
    1190                 1195                 1200             


Leu Cys  Thr Val Asn Ser Val  Glu Glu Lys Ile Leu  Ala Ala Ala 
    1205                 1210                 1215             


Lys Tyr  Lys Leu Asn Val Asp  Gln Lys Val Ile Gln  Ala Gly Met 
    1220                 1225                 1230             


Phe Asp  Gln Lys Ser Ser Ser  His Glu Arg Arg Ala  Phe Leu Gln 
    1235                 1240                 1245             


Ala Ile  Leu Glu His Glu Glu  Gln Asp Glu Glu Glu  Asp Glu Val 
    1250                 1255                 1260             


Pro Asp  Asp Glu Thr Val Asn  Gln Met Ile Ala Arg  His Glu Glu 
    1265                 1270                 1275             


Glu Phe  Asp Leu Phe Met Arg  Met Asp Leu Asp Arg  Arg Arg Glu 
    1280                 1285                 1290             


Glu Ala  Arg Asn Pro Lys Arg  Lys Pro Arg Leu Met  Glu Glu Asp 
    1295                 1300                 1305             


Glu Leu  Pro Ser Trp Ile Ile  Lys Asp Asp Ala Glu  Val Glu Arg 
    1310                 1315                 1320             


Leu Thr  Cys Glu Glu Glu Glu  Glu Lys Met Phe Gly  Arg Gly Ser 
    1325                 1330                 1335             


Arg His  Arg Lys Glu Val Asp  Tyr Ser Asp Ser Leu  Thr Glu Lys 
    1340                 1345                 1350             


Gln Trp  Leu Lys Ala Ile Glu  Glu Gly Thr Leu Glu  Glu Ile Glu 
    1355                 1360                 1365             


Glu Glu  Val Arg Gln Lys Lys  Ser Ser Arg Lys Arg  Lys Arg Asp 
    1370                 1375                 1380             


Ser Glu  Ala Gly Ser Ser Thr  Pro Thr Thr Ser Thr  Arg Ser Arg 
    1385                 1390                 1395             


Asp Lys  Asp Glu Glu Ser Lys  Lys Gln Lys Lys Arg  Gly Arg Pro 
    1400                 1405                 1410             


Pro Ala  Glu Lys Leu Ser Pro  Asn Pro Pro Asn Leu  Thr Lys Lys 
    1415                 1420                 1425             


Met Lys  Lys Ile Val Asp Ala  Val Ile Lys Tyr Lys  Asp Ser Ser 
    1430                 1435                 1440             


Gly Arg  Gln Leu Ser Glu Val  Phe Ile Gln Leu Pro  Ser Arg Lys 
    1445                 1450                 1455             


Glu Leu  Pro Glu Tyr Tyr Glu  Leu Ile Arg Lys Pro  Val Asp Phe 
    1460                 1465                 1470             


Lys Lys  Ile Lys Glu Arg Ile  Arg Asn His Lys Tyr  Arg Ser Leu 
    1475                 1480                 1485             


Asn Asp  Leu Glu Lys Asp Val  Met Leu Leu Cys Gln  Asn Ala Gln 
    1490                 1495                 1500             


Thr Phe  Asn Leu Glu Gly Ser  Leu Ile Tyr Glu Asp  Ser Ile Val 
    1505                 1510                 1515             


Leu Gln  Ser Val Phe Thr Ser  Val Arg Gln Lys Ile  Glu Lys Glu 
    1520                 1525                 1530             


Asp Asp  Ser Glu Gly Glu Glu  Ser Glu Glu Glu Glu  Glu Gly Glu 
    1535                 1540                 1545             


Glu Glu  Gly Ser Glu Ser Glu  Ser Arg Ser Val Lys  Val Lys Ile 
    1550                 1555                 1560             


Lys Leu  Gly Arg Lys Glu Lys  Ala Gln Asp Arg Leu  Lys Gly Gly 
    1565                 1570                 1575             


Arg Arg  Arg Pro Ser Arg Gly  Ser Arg Ala Lys Pro  Val Val Ser 
    1580                 1585                 1590             


Asp Asp  Asp Ser Glu Glu Glu  Gln Glu Glu Asp Arg  Ser Gly Ser 
    1595                 1600                 1605             


Gly Ser  Glu Glu Asp 
    1610             


<210> 210
<211> 6466
<212> DNA
<213> Mus musculus

<400> 210
ggcaagtgga gcgggtagac agggaggcgg gggcgcgcgg cgggcgcgtg cggtgggggg       60

gggtggcctg gcgaagccca gcgggcgcgc gcgcgaggct ttcccactcg cttggcagcg      120

gcggagacgg cttctttgtt tcctgaggag aagcgagacg cccactctgt ccccgacccc      180

tcgtggaggg ttgggggcgg cgccaggaag gttacggcgc cgttacctcc aggagaccag      240

tgcctgtagc tccagtaaag atgtctactc cagacccacc cttgggtggg actcctcggc      300

ctggtccttc cccaggccct ggtccttcac ctggtgcaat gctgggtcct agccctggcc      360

cctcaccagg ttctgcccac agcatgatgg ggccaagccc aggacctcct tcagcaggac      420

atcccatgcc cacccagggg cctggagggt acccccagga caacatgcat cagatgcaca      480

agcctatgga gtccatgcac gagaagggca tgcctgatga cccacgatac aaccagatga      540

aagggatggg catgcggtca ggggcccaca caggcatggc acctccacct agtcccatgg      600

accagcattc tcaaggttac ccctcacccc tcggcggctc tgaacatgcc tccagtcctg      660

tcccagccag tggcccatct tcaggccccc agatgtcctc tgggccagga ggggccccac      720

tagatggttc tgatccccag gccttgggac agcaaaacag aggcccaacc ccatttaacc      780

agaaccagct gcatcaactc agagctcaga taatggccta caagatgttg gccaggggcc      840

agccattgcc cgaccacctg cagatggccg tgcaaggcaa gcggccgatg cctggaatgc      900

agcaacagat gccaacacta cctccaccct cagtgtccgc cacaggaccc ggacctggac      960

ccggccctgg ccctggccct ggcccaggac cagcccctcc aaattacagt agaccccatg     1020

gtatgggagg gcccaacatg cctcccccag gaccctcagg tgtgcccccc gggatgcctg     1080

gtcagccgcc tggagggcct cccaagccat ggcctgaagg acccatggcc aatgctgctg     1140

cccccacaag caccccacag aagctgattc ctccgcaacc aacaggccgt ccttcacctg     1200

cacctcctgc tgtcccgcct gctgcctcac ctgtaatgcc accacaaaca cagtccccag     1260

ggcagccagc ccagcctgct ccattggtgc cactgcacca gaagcagagc cgaatcaccc     1320

ccatccagaa gccccgaggc cttgaccctg tggagatcct acaagagcgg gagtacaggc     1380

ttcaggctcg aatcgcacac agaattcagg aacttgaaaa cctccctggg tccctggctg     1440

gggaccttcg aaccaaagca accatcgaac tcaaggccct taggttgctg aacttccaga     1500

ggcagctgcg ccaggaggtg gtggtgtgca tgcgaagaga cacagccctg gagacagccc     1560

tcaatgccaa ggcctacaag cgcagcaaac gtcagtcact acgggaggcc cgcatcactg     1620

agaagttgga gaagcagcag aagattgaac aggagcgcaa gcgccgccag aagcaccagg     1680

agtacctcaa cagcattctg cagcatgcca aggacttcag ggagtatcac agatcagtca     1740

caggcaaact ccagaaactc accaaggctg tggccaccta ccatgccaac actgagcggg     1800

agcagaagaa agaaaatgag cgcattgaga aggagcgaat gcggaggctt atggctgaag     1860

atgaggaggg ctaccgcaaa ctcattgacc agaagaagga caagcgcctg gcctaccttc     1920

tgcagcagac agatgagtat gtggccaacc tcacagagct ggtgcggcag cacaaagctg     1980

cccaggttgc caaggagaag aagaagaaaa agaaaaagaa gaaggcagaa aatgctgaag     2040

gacagacacc tgctattgga ccagatggtg agcctctgga tgagaccagc cagatgagtg     2100

acctccctgt gaaggtgatc cacgtggaga gtggcaagat cctcactggc acagatgccc     2160

caaaagccgg gcagctggaa gcctggcttg aaatgaaccc agggtatgaa gtagccccca     2220

ggtcagacag tgaagaaagt ggctctgaag aggaggagga ggaggaggaa gaggagcagc     2280

ctcagcccgc acagccccct acactgcctg tggaagaaaa gaagaagatt ccagacccag     2340

acagcgatga tgtctctgag gtggacgccc gacacattat tgagaacgcc aagcaagatg     2400

tggacgatga gtacggtgtg tcccaggccc ttgctcgtgg cctgcagtct tactatgctg     2460

tggcccatgc agtcacagag agagtagata agcagtccgc cctcatggtc aacggtgtcc     2520

tcaaacagta ccagatcaag ggtttggagt ggctggtgtc cctgtacaac aacaacctga     2580

atggcatcct ggctgatgag atggggctgg ggaagaccat ccagaccatc gcgctcatca     2640

catacctcat ggagcacaag cgcatcaacg ggcctttcct catcatcgtg cctctctcga     2700

cactgtcaaa ctgggcgtat gaatttgaca agtgggcccc ctctgtggtg aaggtttctt     2760

acaagggctc tccagctgca aggcgagctt ttgtcccaca gcttcgcagt gggaagttca     2820

acgtcttact gaccacctat gaatatatca tcaaagacaa gcatatccta gccaagatcc     2880

gctggaagta catgattgtg gatgaaggcc accgcatgaa aaaccaccac tgcaagttga     2940

cgcaggtcct taacacacac tacgtggccc ctcggcgcct gcttcttaca ggcacaccac     3000

tgcagaacaa gctaccggag ctctgggccc tgcttaactt cctgctcccc actatcttca     3060

agagctgcag caccttcgaa cagtggttca atgcaccctt tgccatgact ggagaaaagg     3120

tggacctgaa tgaagaggag actatcctca ttattcgtcg cctacacaaa gttctgcggc     3180

ccttcctgct gcggcggctc aagaaggaag ttgaagccca gctccctgag aaggtagagt     3240

atgtcatcaa atgcgacatg tcagccctgc agcgtgtgct gtaccgtcac atgcaggcca     3300

aaggtgtgct gctgactgac ggctccgaga aggacaagaa gggcaaaggt ggcaccaaga     3360

cactgatgaa cactattatg caactgcgta agatctgcaa ccacccctac atgttccagc     3420

acatcgagga gtccttttct gagcacttgg ggttcaccgg cggcatcgtg caaggattgg     3480

acctttaccg tgcctcaggg aaatttgaac ttcttgatag aattctaccc aaactccgtg     3540

caacgaacca taaagtgctc ctcttttgcc aaatgacctc cctcatgacc atcatggaag     3600

actactttgc ataccgtggc ttcaaatacc tcaggcttga tggaaccaca aaagcagaag     3660

accggggcat gctgttgaaa acctttaatg aacctggctc tgagtatttc attttcctgc     3720

tcagtacccg tgctgggggg ctgggcctga atctgcagtc agctgacact gtgatcatct     3780

ttgacagtga ctggaatccc caccaggacc tgcaagcaca ggatcgagcc catcgcattg     3840

gacagcagaa tgaggtgcgt gttcttcgcc tgtgcacggt caacagtgtg gaagagaaga     3900

tactggctgc tgccaaatac aaactcaatg tggatcagaa ggtgatccag gcaggcatgt     3960

tcgaccagaa gtcgtccagc catgagaggc gtgccttcct gcaggccatc ctggagcacg     4020

aggagcagga tgagagcaga cactgcagca cgggcagcgg cagtgccagc ttcgcccaca     4080

ctgcccctcc gccagcgggc gtcaaccccg acttggagga gccacctcta aaggaggaag     4140

atgaggtgcc tgatgatgag accgtcaacc agatgattgc ccggcacgaa gaagagtttg     4200

acctcttcat gcgcatggac ttggaccgcc ggcgtgaaga agcccgcaac cccaagcgga     4260

agccacgcct gatggaagag gatgagctcc catcctggat catcaaggat gatgccgagg     4320

tggagcggct gacatgtgaa gaggaagagg agaagatgtt cggccgtggt tctcgccacc     4380

gcaaggaggt agactacagc gactcactga cagagaagca gtggctcaag gctatcgagg     4440

agggcacgct ggaggagatc gaagaggagg tccggcagaa gaaatcttca cgtaagcgta     4500

agcgagacag cgaggccggc tcctccaccc cgaccaccag cacccgcagc cgtgacaagg     4560

atgaggagag caagaagcag aagaaacgtg ggcggccacc tgctgagaag ctgtccccaa     4620

acccacctaa cctcaccaag aagatgaaga agatcgtgga tgctgtgatc aagtacaaag     4680

acagcagcag tggacgtcag ctcagcgagg tgttcatcca gctcccctct cgcaaggagc     4740

ttcctgagta ctatgagctc atccgaaagc ctgtggactt caagaagatc aaggaacgca     4800

tccgaaacca caagtaccgc agcctcaatg acctggagaa ggatgtgatg ctgctgtgcc     4860

agaacgctca gacgttcaac ctcgagggtt ccctgatcta tgaggactcc atcgtcctgc     4920

agtctgtctt caccagcgta cggcagaaga ttgagaagga ggacgacagt gaaggcgagg     4980

aaagcgagga ggaggaggag ggcgaggagg aaggctccga gtctgagtcc cgctccgtca     5040

aggtgaagat caagctgggc cgcaaggaga aggcccagga ccgactcaag gggggccgcc     5100

ggcggccaag ccggggatcc cgggccaagc cggttgtgag tgacgatgac agtgaggagg     5160

agcaggagga ggaccgctca ggaagtggca gtgaggaaga ctgaaccaga cattcctgag     5220

tcctgacccc gaggcgctcg tcccagccaa gatggagtag cccttagcag tgatgggtag     5280

caccagatgt agtttcgaac ttggagaact gtacacatgc aatcttccac atttttaggc     5340

agagaagtat aggcctgtct gtcggccctg gcctggcctc gagtctctac cagcattaac     5400

tgtctagaga ggggacctcc tgggagcacc atccacctcc ccaggcccca gtcactgtag     5460

ctcagtggat gcatgcgcgt gccggccgct ccttgtactg tatcttactg gacagggcca     5520

gctctccagg aggctcacag gcccagcggg tatgtcagtg tcactggagt cagacagtaa     5580

taaattaaag caatgacaag ccaccactgg ctccctggac tccttgctgt cagcagtggc     5640

tccggggcca cagagaagaa agaaagactt ttaggaactg ggtctaactt atgggcaaag     5700

tacttgcctt gccaggtgta tgggttttgc attcccatca cccacacacc ctaaacaagc     5760

caagtcagtg agcttcaagt tagagcctcc acctcaatgt gtacgtggaa agcaatcaaa     5820

gatgatgcct agcatccacc tctggccctc atgtgcagat gtacacacac tgaattacat     5880

acacgggaca cacacatcca cacggaggca gtccatgact tgcactgggg agatggtacc     5940

ataggcgaaa gtgccacagg cacagggcca ggctaattta gtcctgcagt cctgtgctct     6000

taagatgaag gcacaaagag gaaccccagg cgctccaact agcatgccag gcagtgacaa     6060

gaccctgctt caaatgaatc agagcccaca ttcagtattg ccctcttacc cgatgcgatg     6120

cccatgccct cacatatgaa tgtgtatata tacatacata cgtaaaataa ttctttttta     6180

aattatagac atttttgtgt gaatgttttg cctgaatgtg tgtgtgtgtg tgtgtgtgtg     6240

tgtgtgtgtg tgtgtgtgtg tatcaagtac attcctagag cctacagagg tcaagggagg     6300

gcattggatc tggaactgga gtcacatgag gctgtgagca actgtgtggg ttcctgggcc     6360

tttgcaacag cagttagtac tcttcaccac tgagccattt ctccaatctc aaaaagaagc     6420

attcttttaa atgaagactg aaataaataa gtaggacttg ccttgg                    6466


<210> 211
<211> 1647
<212> PRT
<213> Mus musculus

<400> 211
Met Ser Thr Pro Asp Pro Pro Leu Gly Gly Thr Pro Arg Pro Gly Pro 
1               5                   10                  15      


Ser Pro Gly Pro Gly Pro Ser Pro Gly Ala Met Leu Gly Pro Ser Pro 
            20                  25                  30          


Gly Pro Ser Pro Gly Ser Ala His Ser Met Met Gly Pro Ser Pro Gly 
        35                  40                  45              


Pro Pro Ser Ala Gly His Pro Met Pro Thr Gln Gly Pro Gly Gly Tyr 
    50                  55                  60                  


Pro Gln Asp Asn Met His Gln Met His Lys Pro Met Glu Ser Met His 
65                  70                  75                  80  


Glu Lys Gly Met Pro Asp Asp Pro Arg Tyr Asn Gln Met Lys Gly Met 
                85                  90                  95      


Gly Met Arg Ser Gly Ala His Thr Gly Met Ala Pro Pro Pro Ser Pro 
            100                 105                 110         


Met Asp Gln His Ser Gln Gly Tyr Pro Ser Pro Leu Gly Gly Ser Glu 
        115                 120                 125             


His Ala Ser Ser Pro Val Pro Ala Ser Gly Pro Ser Ser Gly Pro Gln 
    130                 135                 140                 


Met Ser Ser Gly Pro Gly Gly Ala Pro Leu Asp Gly Ser Asp Pro Gln 
145                 150                 155                 160 


Ala Leu Gly Gln Gln Asn Arg Gly Pro Thr Pro Phe Asn Gln Asn Gln 
                165                 170                 175     


Leu His Gln Leu Arg Ala Gln Ile Met Ala Tyr Lys Met Leu Ala Arg 
            180                 185                 190         


Gly Gln Pro Leu Pro Asp His Leu Gln Met Ala Val Gln Gly Lys Arg 
        195                 200                 205             


Pro Met Pro Gly Met Gln Gln Gln Met Pro Thr Leu Pro Pro Pro Ser 
    210                 215                 220                 


Val Ser Ala Thr Gly Pro Gly Pro Gly Pro Gly Pro Gly Pro Gly Pro 
225                 230                 235                 240 


Gly Pro Gly Pro Ala Pro Pro Asn Tyr Ser Arg Pro His Gly Met Gly 
                245                 250                 255     


Gly Pro Asn Met Pro Pro Pro Gly Pro Ser Gly Val Pro Pro Gly Met 
            260                 265                 270         


Pro Gly Gln Pro Pro Gly Gly Pro Pro Lys Pro Trp Pro Glu Gly Pro 
        275                 280                 285             


Met Ala Asn Ala Ala Ala Pro Thr Ser Thr Pro Gln Lys Leu Ile Pro 
    290                 295                 300                 


Pro Gln Pro Thr Gly Arg Pro Ser Pro Ala Pro Pro Ala Val Pro Pro 
305                 310                 315                 320 


Ala Ala Ser Pro Val Met Pro Pro Gln Thr Gln Ser Pro Gly Gln Pro 
                325                 330                 335     


Ala Gln Pro Ala Pro Leu Val Pro Leu His Gln Lys Gln Ser Arg Ile 
            340                 345                 350         


Thr Pro Ile Gln Lys Pro Arg Gly Leu Asp Pro Val Glu Ile Leu Gln 
        355                 360                 365             


Glu Arg Glu Tyr Arg Leu Gln Ala Arg Ile Ala His Arg Ile Gln Glu 
    370                 375                 380                 


Leu Glu Asn Leu Pro Gly Ser Leu Ala Gly Asp Leu Arg Thr Lys Ala 
385                 390                 395                 400 


Thr Ile Glu Leu Lys Ala Leu Arg Leu Leu Asn Phe Gln Arg Gln Leu 
                405                 410                 415     


Arg Gln Glu Val Val Val Cys Met Arg Arg Asp Thr Ala Leu Glu Thr 
            420                 425                 430         


Ala Leu Asn Ala Lys Ala Tyr Lys Arg Ser Lys Arg Gln Ser Leu Arg 
        435                 440                 445             


Glu Ala Arg Ile Thr Glu Lys Leu Glu Lys Gln Gln Lys Ile Glu Gln 
    450                 455                 460                 


Glu Arg Lys Arg Arg Gln Lys His Gln Glu Tyr Leu Asn Ser Ile Leu 
465                 470                 475                 480 


Gln His Ala Lys Asp Phe Arg Glu Tyr His Arg Ser Val Thr Gly Lys 
                485                 490                 495     


Leu Gln Lys Leu Thr Lys Ala Val Ala Thr Tyr His Ala Asn Thr Glu 
            500                 505                 510         


Arg Glu Gln Lys Lys Glu Asn Glu Arg Ile Glu Lys Glu Arg Met Arg 
        515                 520                 525             


Arg Leu Met Ala Glu Asp Glu Glu Gly Tyr Arg Lys Leu Ile Asp Gln 
    530                 535                 540                 


Lys Lys Asp Lys Arg Leu Ala Tyr Leu Leu Gln Gln Thr Asp Glu Tyr 
545                 550                 555                 560 


Val Ala Asn Leu Thr Glu Leu Val Arg Gln His Lys Ala Ala Gln Val 
                565                 570                 575     


Ala Lys Glu Lys Lys Lys Lys Lys Lys Lys Lys Lys Ala Glu Asn Ala 
            580                 585                 590         


Glu Gly Gln Thr Pro Ala Ile Gly Pro Asp Gly Glu Pro Leu Asp Glu 
        595                 600                 605             


Thr Ser Gln Met Ser Asp Leu Pro Val Lys Val Ile His Val Glu Ser 
    610                 615                 620                 


Gly Lys Ile Leu Thr Gly Thr Asp Ala Pro Lys Ala Gly Gln Leu Glu 
625                 630                 635                 640 


Ala Trp Leu Glu Met Asn Pro Gly Tyr Glu Val Ala Pro Arg Ser Asp 
                645                 650                 655     


Ser Glu Glu Ser Gly Ser Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu 
            660                 665                 670         


Gln Pro Gln Pro Ala Gln Pro Pro Thr Leu Pro Val Glu Glu Lys Lys 
        675                 680                 685             


Lys Ile Pro Asp Pro Asp Ser Asp Asp Val Ser Glu Val Asp Ala Arg 
    690                 695                 700                 


His Ile Ile Glu Asn Ala Lys Gln Asp Val Asp Asp Glu Tyr Gly Val 
705                 710                 715                 720 


Ser Gln Ala Leu Ala Arg Gly Leu Gln Ser Tyr Tyr Ala Val Ala His 
                725                 730                 735     


Ala Val Thr Glu Arg Val Asp Lys Gln Ser Ala Leu Met Val Asn Gly 
            740                 745                 750         


Val Leu Lys Gln Tyr Gln Ile Lys Gly Leu Glu Trp Leu Val Ser Leu 
        755                 760                 765             


Tyr Asn Asn Asn Leu Asn Gly Ile Leu Ala Asp Glu Met Gly Leu Gly 
    770                 775                 780                 


Lys Thr Ile Gln Thr Ile Ala Leu Ile Thr Tyr Leu Met Glu His Lys 
785                 790                 795                 800 


Arg Ile Asn Gly Pro Phe Leu Ile Ile Val Pro Leu Ser Thr Leu Ser 
                805                 810                 815     


Asn Trp Ala Tyr Glu Phe Asp Lys Trp Ala Pro Ser Val Val Lys Val 
            820                 825                 830         


Ser Tyr Lys Gly Ser Pro Ala Ala Arg Arg Ala Phe Val Pro Gln Leu 
        835                 840                 845             


Arg Ser Gly Lys Phe Asn Val Leu Leu Thr Thr Tyr Glu Tyr Ile Ile 
    850                 855                 860                 


Lys Asp Lys His Ile Leu Ala Lys Ile Arg Trp Lys Tyr Met Ile Val 
865                 870                 875                 880 


Asp Glu Gly His Arg Met Lys Asn His His Cys Lys Leu Thr Gln Val 
                885                 890                 895     


Leu Asn Thr His Tyr Val Ala Pro Arg Arg Leu Leu Leu Thr Gly Thr 
            900                 905                 910         


Pro Leu Gln Asn Lys Leu Pro Glu Leu Trp Ala Leu Leu Asn Phe Leu 
        915                 920                 925             


Leu Pro Thr Ile Phe Lys Ser Cys Ser Thr Phe Glu Gln Trp Phe Asn 
    930                 935                 940                 


Ala Pro Phe Ala Met Thr Gly Glu Lys Val Asp Leu Asn Glu Glu Glu 
945                 950                 955                 960 


Thr Ile Leu Ile Ile Arg Arg Leu His Lys Val Leu Arg Pro Phe Leu 
                965                 970                 975     


Leu Arg Arg Leu Lys Lys Glu Val Glu Ala Gln Leu Pro Glu Lys Val 
            980                 985                 990         


Glu Tyr Val Ile Lys Cys Asp Met  Ser Ala Leu Gln Arg  Val Leu Tyr 
        995                 1000                 1005             


Arg His  Met Gln Ala Lys Gly  Val Leu Leu Thr Asp  Gly Ser Glu 
    1010                 1015                 1020             


Lys Asp  Lys Lys Gly Lys Gly  Gly Thr Lys Thr Leu  Met Asn Thr 
    1025                 1030                 1035             


Ile Met  Gln Leu Arg Lys Ile  Cys Asn His Pro Tyr  Met Phe Gln 
    1040                 1045                 1050             


His Ile  Glu Glu Ser Phe Ser  Glu His Leu Gly Phe  Thr Gly Gly 
    1055                 1060                 1065             


Ile Val  Gln Gly Leu Asp Leu  Tyr Arg Ala Ser Gly  Lys Phe Glu 
    1070                 1075                 1080             


Leu Leu  Asp Arg Ile Leu Pro  Lys Leu Arg Ala Thr  Asn His Lys 
    1085                 1090                 1095             


Val Leu  Leu Phe Cys Gln Met  Thr Ser Leu Met Thr  Ile Met Glu 
    1100                 1105                 1110             


Asp Tyr  Phe Ala Tyr Arg Gly  Phe Lys Tyr Leu Arg  Leu Asp Gly 
    1115                 1120                 1125             


Thr Thr  Lys Ala Glu Asp Arg  Gly Met Leu Leu Lys  Thr Phe Asn 
    1130                 1135                 1140             


Glu Pro  Gly Ser Glu Tyr Phe  Ile Phe Leu Leu Ser  Thr Arg Ala 
    1145                 1150                 1155             


Gly Gly  Leu Gly Leu Asn Leu  Gln Ser Ala Asp Thr  Val Ile Ile 
    1160                 1165                 1170             


Phe Asp  Ser Asp Trp Asn Pro  His Gln Asp Leu Gln  Ala Gln Asp 
    1175                 1180                 1185             


Arg Ala  His Arg Ile Gly Gln  Gln Asn Glu Val Arg  Val Leu Arg 
    1190                 1195                 1200             


Leu Cys  Thr Val Asn Ser Val  Glu Glu Lys Ile Leu  Ala Ala Ala 
    1205                 1210                 1215             


Lys Tyr  Lys Leu Asn Val Asp  Gln Lys Val Ile Gln  Ala Gly Met 
    1220                 1225                 1230             


Phe Asp  Gln Lys Ser Ser Ser  His Glu Arg Arg Ala  Phe Leu Gln 
    1235                 1240                 1245             


Ala Ile  Leu Glu His Glu Glu  Gln Asp Glu Ser Arg  His Cys Ser 
    1250                 1255                 1260             


Thr Gly  Ser Gly Ser Ala Ser  Phe Ala His Thr Ala  Pro Pro Pro 
    1265                 1270                 1275             


Ala Gly  Val Asn Pro Asp Leu  Glu Glu Pro Pro Leu  Lys Glu Glu 
    1280                 1285                 1290             


Asp Glu  Val Pro Asp Asp Glu  Thr Val Asn Gln Met  Ile Ala Arg 
    1295                 1300                 1305             


His Glu  Glu Glu Phe Asp Leu  Phe Met Arg Met Asp  Leu Asp Arg 
    1310                 1315                 1320             


Arg Arg  Glu Glu Ala Arg Asn  Pro Lys Arg Lys Pro  Arg Leu Met 
    1325                 1330                 1335             


Glu Glu  Asp Glu Leu Pro Ser  Trp Ile Ile Lys Asp  Asp Ala Glu 
    1340                 1345                 1350             


Val Glu  Arg Leu Thr Cys Glu  Glu Glu Glu Glu Lys  Met Phe Gly 
    1355                 1360                 1365             


Arg Gly  Ser Arg His Arg Lys  Glu Val Asp Tyr Ser  Asp Ser Leu 
    1370                 1375                 1380             


Thr Glu  Lys Gln Trp Leu Lys  Ala Ile Glu Glu Gly  Thr Leu Glu 
    1385                 1390                 1395             


Glu Ile  Glu Glu Glu Val Arg  Gln Lys Lys Ser Ser  Arg Lys Arg 
    1400                 1405                 1410             


Lys Arg  Asp Ser Glu Ala Gly  Ser Ser Thr Pro Thr  Thr Ser Thr 
    1415                 1420                 1425             


Arg Ser  Arg Asp Lys Asp Glu  Glu Ser Lys Lys Gln  Lys Lys Arg 
    1430                 1435                 1440             


Gly Arg  Pro Pro Ala Glu Lys  Leu Ser Pro Asn Pro  Pro Asn Leu 
    1445                 1450                 1455             


Thr Lys  Lys Met Lys Lys Ile  Val Asp Ala Val Ile  Lys Tyr Lys 
    1460                 1465                 1470             


Asp Ser  Ser Ser Gly Arg Gln  Leu Ser Glu Val Phe  Ile Gln Leu 
    1475                 1480                 1485             


Pro Ser  Arg Lys Glu Leu Pro  Glu Tyr Tyr Glu Leu  Ile Arg Lys 
    1490                 1495                 1500             


Pro Val  Asp Phe Lys Lys Ile  Lys Glu Arg Ile Arg  Asn His Lys 
    1505                 1510                 1515             


Tyr Arg  Ser Leu Asn Asp Leu  Glu Lys Asp Val Met  Leu Leu Cys 
    1520                 1525                 1530             


Gln Asn  Ala Gln Thr Phe Asn  Leu Glu Gly Ser Leu  Ile Tyr Glu 
    1535                 1540                 1545             


Asp Ser  Ile Val Leu Gln Ser  Val Phe Thr Ser Val  Arg Gln Lys 
    1550                 1555                 1560             


Ile Glu  Lys Glu Asp Asp Ser  Glu Gly Glu Glu Ser  Glu Glu Glu 
    1565                 1570                 1575             


Glu Glu  Gly Glu Glu Glu Gly  Ser Glu Ser Glu Ser  Arg Ser Val 
    1580                 1585                 1590             


Lys Val  Lys Ile Lys Leu Gly  Arg Lys Glu Lys Ala  Gln Asp Arg 
    1595                 1600                 1605             


Leu Lys  Gly Gly Arg Arg Arg  Pro Ser Arg Gly Ser  Arg Ala Lys 
    1610                 1615                 1620             


Pro Val  Val Ser Asp Asp Asp  Ser Glu Glu Glu Gln  Glu Glu Asp 
    1625                 1630                 1635             


Arg Ser  Gly Ser Gly Ser Glu  Glu Asp 
    1640                 1645         


<210> 212
<211> 6376
<212> DNA
<213> Mus musculus

<400> 212
ggcaagtgga gcgggtagac agggaggcgg gggcgcgcgg cgggcgcgtg cggtgggggg       60

gggtggcctg gcgaagccca gcgggcgcgc gcgcgaggct ttcccactcg cttggcagcg      120

gcggagacgg cttctttgtt tcctgaggag aagcgagacg cccactctgt ccccgacccc      180

tcgtggaggg ttgggggcgg cgccaggaag gttacggcgc cgttacctcc aggagaccag      240

tgcctgtagc tccagtaaag atgtctactc cagacccacc cttgggtggg actcctcggc      300

ctggtccttc cccaggccct ggtccttcac ctggtgcaat gctgggtcct agccctggcc      360

cctcaccagg ttctgcccac agcatgatgg ggccaagccc aggacctcct tcagcaggac      420

atcccatgcc cacccagggg cctggagggt acccccagga caacatgcat cagatgcaca      480

agcctatgga gtccatgcac gagaagggca tgcctgatga cccacgatac aaccagatga      540

aagggatggg catgcggtca ggggcccaca caggcatggc acctccacct agtcccatgg      600

accagcattc tcaaggttac ccctcacccc tcggcggctc tgaacatgcc tccagtcctg      660

tcccagccag tggcccatct tcaggccccc agatgtcctc tgggccagga ggggccccac      720

tagatggttc tgatccccag gccttgggac agcaaaacag aggcccaacc ccatttaacc      780

agaaccagct gcatcaactc agagctcaga taatggccta caagatgttg gccaggggcc      840

agccattgcc cgaccacctg cagatggccg tgcaaggcaa gcggccgatg cctggaatgc      900

agcaacagat gccaacacta cctccaccct cagtgtccgc cacaggaccc ggacctggac      960

ccggccctgg ccctggccct ggcccaggac cagcccctcc aaattacagt agaccccatg     1020

gtatgggagg gcccaacatg cctcccccag gaccctcagg tgtgcccccc gggatgcctg     1080

gtcagccgcc tggagggcct cccaagccat ggcctgaagg acccatggcc aatgctgctg     1140

cccccacaag caccccacag aagctgattc ctccgcaacc aacaggccgt ccttcacctg     1200

cacctcctgc tgtcccgcct gctgcctcac ctgtaatgcc accacaaaca cagtccccag     1260

ggcagccagc ccagcctgct ccattggtgc cactgcacca gaagcagagc cgaatcaccc     1320

ccatccagaa gccccgaggc cttgaccctg tggagatcct acaagagcgg gagtacaggc     1380

ttcaggctcg aatcgcacac agaattcagg aacttgaaaa cctccctggg tccctggctg     1440

gggaccttcg aaccaaagca accatcgaac tcaaggccct taggttgctg aacttccaga     1500

ggcagctgcg ccaggaggtg gtggtgtgca tgcgaagaga cacagccctg gagacagccc     1560

tcaatgccaa ggcctacaag cgcagcaaac gtcagtcact acgggaggcc cgcatcactg     1620

agaagttgga gaagcagcag aagattgaac aggagcgcaa gcgccgccag aagcaccagg     1680

agtacctcaa cagcattctg cagcatgcca aggacttcag ggagtatcac agatcagtca     1740

caggcaaact ccagaaactc accaaggctg tggccaccta ccatgccaac actgagcggg     1800

agcagaagaa agaaaatgag cgcattgaga aggagcgaat gcggaggctt atggctgaag     1860

atgaggaggg ctaccgcaaa ctcattgacc agaagaagga caagcgcctg gcctaccttc     1920

tgcagcagac agatgagtat gtggccaacc tcacagagct ggtgcggcag cacaaagctg     1980

cccaggttgc caaggagaag aagaagaaaa agaaaaagaa gaaggcagaa aatgctgaag     2040

gacagacacc tgctattgga ccagatggtg agcctctgga tgagaccagc cagatgagtg     2100

acctccctgt gaaggtgatc cacgtggaga gtggcaagat cctcactggc acagatgccc     2160

caaaagccgg gcagctggaa gcctggcttg aaatgaaccc agggtatgaa gtagccccca     2220

ggtcagacag tgaagaaagt ggctctgaag aggaggagga ggaggaggaa gaggagcagc     2280

ctcagcccgc acagccccct acactgcctg tggaagaaaa gaagaagatt ccagacccag     2340

acagcgatga tgtctctgag gtggacgccc gacacattat tgagaacgcc aagcaagatg     2400

tggacgatga gtacggtgtg tcccaggccc ttgctcgtgg cctgcagtct tactatgctg     2460

tggcccatgc agtcacagag agagtagata agcagtccgc cctcatggtc aacggtgtcc     2520

tcaaacagta ccagatcaag ggtttggagt ggctggtgtc cctgtacaac aacaacctga     2580

atggcatcct ggctgatgag atggggctgg ggaagaccat ccagaccatc gcgctcatca     2640

catacctcat ggagcacaag cgcatcaacg ggcctttcct catcatcgtg cctctctcga     2700

cactgtcaaa ctgggcgtat gaatttgaca agtgggcccc ctctgtggtg aaggtttctt     2760

acaagggctc tccagctgca aggcgagctt ttgtcccaca gcttcgcagt gggaagttca     2820

acgtcttact gaccacctat gaatatatca tcaaagacaa gcatatccta gccaagatcc     2880

gctggaagta catgattgtg gatgaaggcc accgcatgaa aaaccaccac tgcaagttga     2940

cgcaggtcct taacacacac tacgtggccc ctcggcgcct gcttcttaca ggcacaccac     3000

tgcagaacaa gctaccggag ctctgggccc tgcttaactt cctgctcccc actatcttca     3060

agagctgcag caccttcgaa cagtggttca atgcaccctt tgccatgact ggagaaaagg     3120

tggacctgaa tgaagaggag actatcctca ttattcgtcg cctacacaaa gttctgcggc     3180

ccttcctgct gcggcggctc aagaaggaag ttgaagccca gctccctgag aaggtagagt     3240

atgtcatcaa atgcgacatg tcagccctgc agcgtgtgct gtaccgtcac atgcaggcca     3300

aaggtgtgct gctgactgac ggctccgaga aggacaagaa gggcaaaggt ggcaccaaga     3360

cactgatgaa cactattatg caactgcgta agatctgcaa ccacccctac atgttccagc     3420

acatcgagga gtccttttct gagcacttgg ggttcaccgg cggcatcgtg caaggattgg     3480

acctttaccg tgcctcaggg aaatttgaac ttcttgatag aattctaccc aaactccgtg     3540

caacgaacca taaagtgctc ctcttttgcc aaatgacctc cctcatgacc atcatggaag     3600

actactttgc ataccgtggc ttcaaatacc tcaggcttga tggaaccaca aaagcagaag     3660

accggggcat gctgttgaaa acctttaatg aacctggctc tgagtatttc attttcctgc     3720

tcagtacccg tgctgggggg ctgggcctga atctgcagtc agctgacact gtgatcatct     3780

ttgacagtga ctggaatccc caccaggacc tgcaagcaca ggatcgagcc catcgcattg     3840

gacagcagaa tgaggtgcgt gttcttcgcc tgtgcacggt caacagtgtg gaagagaaga     3900

tactggctgc tgccaaatac aaactcaatg tggatcagaa ggtgatccag gcaggcatgt     3960

tcgaccagaa gtcgtccagc catgagaggc gtgccttcct gcaggccatc ctggagcacg     4020

aggagcagga tgaggaggaa gatgaggtgc ctgatgatga gaccgtcaac cagatgattg     4080

cccggcacga agaagagttt gacctcttca tgcgcatgga cttggaccgc cggcgtgaag     4140

aagcccgcaa ccccaagcgg aagccacgcc tgatggaaga ggatgagctc ccatcctgga     4200

tcatcaagga tgatgccgag gtggagcggc tgacatgtga agaggaagag gagaagatgt     4260

tcggccgtgg ttctcgccac cgcaaggagg tagactacag cgactcactg acagagaagc     4320

agtggctcaa gaccctgaag gctatcgagg agggcacgct ggaggagatc gaagaggagg     4380

tccggcagaa gaaatcttca cgtaagcgta agcgagacag cgaggccggc tcctccaccc     4440

cgaccaccag cacccgcagc cgtgacaagg atgaggagag caagaagcag aagaaacgtg     4500

ggcggccacc tgctgagaag ctgtccccaa acccacctaa cctcaccaag aagatgaaga     4560

agatcgtgga tgctgtgatc aagtacaaag acagcagcag tggacgtcag ctcagcgagg     4620

tgttcatcca gctcccctct cgcaaggagc ttcctgagta ctatgagctc atccgaaagc     4680

ctgtggactt caagaagatc aaggaacgca tccgaaacca caagtaccgc agcctcaatg     4740

acctggagaa ggatgtgatg ctgctgtgcc agaacgctca gacgttcaac ctcgagggtt     4800

ccctgatcta tgaggactcc atcgtcctgc agtctgtctt caccagcgta cggcagaaga     4860

ttgagaagga ggacgacagt gaaggcgagg aaagcgagga ggaggaggag ggcgaggagg     4920

aaggctccga gtctgagtcc cgctccgtca aggtgaagat caagctgggc cgcaaggaga     4980

aggcccagga ccgactcaag gggggccgcc ggcggccaag ccggggatcc cgggccaagc     5040

cggttgtgag tgacgatgac agtgaggagg agcaggagga ggaccgctca ggaagtggca     5100

gtgaggaaga ctgaaccaga cattcctgag tcctgacccc gaggcgctcg tcccagccaa     5160

gatggagtag cccttagcag tgatgggtag caccagatgt agtttcgaac ttggagaact     5220

gtacacatgc aatcttccac atttttaggc agagaagtat aggcctgtct gtcggccctg     5280

gcctggcctc gagtctctac cagcattaac tgtctagaga ggggacctcc tgggagcacc     5340

atccacctcc ccaggcccca gtcactgtag ctcagtggat gcatgcgcgt gccggccgct     5400

ccttgtactg tatcttactg gacagggcca gctctccagg aggctcacag gcccagcggg     5460

tatgtcagtg tcactggagt cagacagtaa taaattaaag caatgacaag ccaccactgg     5520

ctccctggac tccttgctgt cagcagtggc tccggggcca cagagaagaa agaaagactt     5580

ttaggaactg ggtctaactt atgggcaaag tacttgcctt gccaggtgta tgggttttgc     5640

attcccatca cccacacacc ctaaacaagc caagtcagtg agcttcaagt tagagcctcc     5700

acctcaatgt gtacgtggaa agcaatcaaa gatgatgcct agcatccacc tctggccctc     5760

atgtgcagat gtacacacac tgaattacat acacgggaca cacacatcca cacggaggca     5820

gtccatgact tgcactgggg agatggtacc ataggcgaaa gtgccacagg cacagggcca     5880

ggctaattta gtcctgcagt cctgtgctct taagatgaag gcacaaagag gaaccccagg     5940

cgctccaact agcatgccag gcagtgacaa gaccctgctt caaatgaatc agagcccaca     6000

ttcagtattg ccctcttacc cgatgcgatg cccatgccct cacatatgaa tgtgtatata     6060

tacatacata cgtaaaataa ttctttttta aattatagac atttttgtgt gaatgttttg     6120

cctgaatgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tatcaagtac     6180

attcctagag cctacagagg tcaagggagg gcattggatc tggaactgga gtcacatgag     6240

gctgtgagca actgtgtggg ttcctgggcc tttgcaacag cagttagtac tcttcaccac     6300

tgagccattt ctccaatctc aaaaagaagc attcttttaa atgaagactg aaataaataa     6360

gtaggacttg ccttgg                                                     6376


<210> 213
<211> 136
<212> PRT
<213> Homo sapiens

<400> 213
Met Ala Arg Thr Lys Gln Thr Ala Arg Lys Ser Thr Gly Gly Lys Ala 
1               5                   10                  15      


Pro Arg Lys Gln Leu Ala Thr Lys Ala Ala Arg Lys Ser Ala Pro Ala 
            20                  25                  30          


Thr Gly Gly Val Lys Lys Pro His Arg Tyr Arg Pro Gly Thr Val Ala 
        35                  40                  45              


Leu Arg Glu Ile Arg Arg Tyr Gln Lys Ser Thr Glu Leu Leu Ile Arg 
    50                  55                  60                  


Lys Leu Pro Phe Gln Arg Leu Val Arg Glu Ile Ala Gln Asp Phe Lys 
65                  70                  75                  80  


Thr Asp Leu Arg Phe Gln Ser Ser Ala Val Met Ala Leu Gln Glu Ala 
                85                  90                  95      


Cys Glu Ala Tyr Leu Val Gly Leu Phe Glu Asp Thr Asn Leu Cys Ala 
            100                 105                 110         


Ile His Ala Lys Arg Val Thr Ile Met Pro Lys Asp Ile Gln Leu Ala 
        115                 120                 125             


Arg Arg Ile Arg Gly Glu Arg Ala 
    130                 135     


<210> 214
<211> 136
<212> PRT
<213> Mus musculus

<400> 214
Met Ala Arg Thr Lys Gln Thr Ala Arg Lys Ser Thr Gly Gly Lys Ala 
1               5                   10                  15      


Pro Arg Lys Gln Leu Ala Thr Lys Ala Ala Arg Lys Ser Ala Pro Ala 
            20                  25                  30          


Thr Gly Gly Val Lys Lys Pro His Arg Tyr Arg Pro Gly Thr Val Ala 
        35                  40                  45              


Leu Arg Glu Ile Arg Arg Tyr Gln Lys Ser Thr Glu Leu Leu Ile Arg 
    50                  55                  60                  


Lys Leu Pro Phe Gln Arg Leu Val Arg Glu Ile Ala Gln Asp Phe Lys 
65                  70                  75                  80  


Thr Asp Leu Arg Phe Gln Ser Ser Ala Val Met Ala Leu Gln Glu Ala 
                85                  90                  95      


Cys Glu Ala Tyr Leu Val Gly Leu Phe Glu Asp Thr Asn Leu Cys Ala 
            100                 105                 110         


Ile His Ala Lys Arg Val Thr Ile Met Pro Lys Asp Ile Gln Leu Ala 
        115                 120                 125             


Arg Arg Ile Arg Gly Glu Arg Ala 
    130                 135     


<210> 215
<211> 136
<212> PRT
<213> Homo sapiens

<400> 215
Met Ala Arg Thr Lys Gln Thr Ala Arg Lys Ser Thr Gly Gly Lys Ala 
1               5                   10                  15      


Pro Arg Lys Gln Leu Ala Thr Lys Ala Ala Arg Lys Ser Ala Pro Ala 
            20                  25                  30          


Thr Gly Gly Val Lys Lys Pro His Arg Tyr Arg Pro Gly Thr Val Ala 
        35                  40                  45              


Leu Arg Glu Ile Arg Arg Tyr Gln Lys Ser Thr Glu Leu Leu Ile Arg 
    50                  55                  60                  


Lys Leu Pro Phe Gln Arg Leu Val Arg Glu Ile Ala Gln Asp Phe Lys 
65                  70                  75                  80  


Thr Asp Leu Arg Phe Gln Ser Ser Ala Val Met Ala Leu Gln Glu Ala 
                85                  90                  95      


Ser Glu Ala Tyr Leu Val Gly Leu Phe Glu Asp Thr Asn Leu Cys Ala 
            100                 105                 110         


Ile His Ala Lys Arg Val Thr Ile Met Pro Lys Asp Ile Gln Leu Ala 
        115                 120                 125             


Arg Arg Ile Arg Gly Glu Arg Ala 
    130                 135     


<210> 216
<211> 136
<212> PRT
<213> Mus musculus

<400> 216
Met Ala Arg Thr Lys Gln Thr Ala Arg Lys Ser Thr Gly Gly Lys Ala 
1               5                   10                  15      


Pro Arg Lys Gln Leu Ala Thr Lys Ala Ala Arg Lys Ser Ala Pro Ala 
            20                  25                  30          


Thr Gly Gly Val Lys Lys Pro His Arg Tyr Arg Pro Gly Thr Val Ala 
        35                  40                  45              


Leu Arg Glu Ile Arg Arg Tyr Gln Lys Ser Thr Glu Leu Leu Ile Arg 
    50                  55                  60                  


Lys Leu Pro Phe Gln Arg Leu Val Arg Glu Ile Ala Gln Asp Phe Lys 
65                  70                  75                  80  


Thr Asp Leu Arg Phe Gln Ser Ser Ala Val Met Ala Leu Gln Glu Ala 
                85                  90                  95      


Ser Glu Ala Tyr Leu Val Gly Leu Phe Glu Asp Thr Asn Leu Cys Ala 
            100                 105                 110         


Ile His Ala Lys Arg Val Thr Ile Met Pro Lys Asp Ile Gln Leu Ala 
        115                 120                 125             


Arg Arg Ile Arg Gly Glu Arg Ala 
    130                 135     


<210> 217
<211> 136
<212> PRT
<213> Homo sapiens

<400> 217
Met Ala Arg Thr Lys Gln Thr Ala Arg Lys Ser Thr Gly Gly Lys Ala 
1               5                   10                  15      


Pro Arg Lys Gln Leu Ala Thr Lys Ala Ala Arg Lys Ser Ala Pro Ser 
            20                  25                  30          


Thr Gly Gly Val Lys Lys Pro His Arg Tyr Arg Pro Gly Thr Val Ala 
        35                  40                  45              


Leu Arg Glu Ile Arg Arg Tyr Gln Lys Ser Thr Glu Leu Leu Ile Arg 
    50                  55                  60                  


Lys Leu Pro Phe Gln Arg Leu Val Arg Glu Ile Ala Gln Asp Phe Lys 
65                  70                  75                  80  


Thr Asp Leu Arg Phe Gln Ser Ala Ala Ile Gly Ala Leu Gln Glu Ala 
                85                  90                  95      


Ser Glu Ala Tyr Leu Val Gly Leu Phe Glu Asp Thr Asn Leu Cys Ala 
            100                 105                 110         


Ile His Ala Lys Arg Val Thr Ile Met Pro Lys Asp Ile Gln Leu Ala 
        115                 120                 125             


Arg Arg Ile Arg Gly Glu Arg Ala 
    130                 135     


<210> 218
<211> 136
<212> PRT
<213> Mus musculus

<400> 218
Met Ala Arg Thr Lys Gln Thr Ala Arg Lys Ser Thr Gly Gly Lys Ala 
1               5                   10                  15      


Pro Arg Lys Gln Leu Ala Thr Lys Ala Ala Arg Lys Ser Ala Pro Ser 
            20                  25                  30          


Thr Gly Gly Val Lys Lys Pro His Arg Tyr Arg Pro Gly Thr Val Ala 
        35                  40                  45              


Leu Arg Glu Ile Arg Arg Tyr Gln Lys Ser Thr Glu Leu Leu Ile Arg 
    50                  55                  60                  


Lys Leu Pro Phe Gln Arg Leu Val Arg Glu Ile Ala Gln Asp Phe Lys 
65                  70                  75                  80  


Thr Asp Leu Arg Phe Gln Ser Ala Ala Ile Gly Ala Leu Gln Glu Ala 
                85                  90                  95      


Ser Glu Ala Tyr Leu Val Gly Leu Phe Glu Asp Thr Asn Leu Cys Ala 
            100                 105                 110         


Ile His Ala Lys Arg Val Thr Ile Met Pro Lys Asp Ile Gln Leu Ala 
        115                 120                 125             


Arg Arg Ile Arg Gly Glu Arg Ala 
    130                 135     


<210> 219
<211> 6
<212> PRT
<213> Homo sapiens

<400> 219
Arg Leu Arg Glu Arg Lys 
1               5       


<210> 220
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 220
Ala Ala Ala Ala Ala Ala 
1               5       


<210> 221
<211> 7
<212> PRT
<213> Homo sapiens

<400> 221
Asp Pro Glu Glu Asp Asp Glu 
1               5           


<210> 222
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 222
Ala Ala Ala Ala Ala Ala Ala 
1               5           


<210> 223
<211> 11
<212> PRT
<213> Homo sapiens

<400> 223
His Ala Trp Thr His Arg Leu Arg Glu Arg Lys 
1               5                   10      


<210> 224
<211> 39
<212> PRT
<213> Homo sapiens

<400> 224
Glu Leu Arg Lys Lys Glu Thr Glu Arg Lys Met Tyr Ser Leu Arg Glu 
1               5                   10                  15      


Arg Lys Gly His Ala Tyr Lys Glu Val Ser Glu Pro Gln Asp Asp Asp 
            20                  25                  30          


Tyr Leu Tyr Cys Glu Met Cys 
        35                  


<210> 225
<211> 457
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 225
Met Ser Val Ala Phe Ala Ala Pro Arg Gln Arg Gly Lys Gly Glu Ile 
1               5                   10                  15      


Thr Pro Ala Ala Ile Gln Lys Met Leu Asp Asp Asn Asn His Leu Ile 
            20                  25                  30          


Gln Cys Ile Met Asp Ser Gln Asn Lys Gly Lys Thr Ser Glu Cys Ser 
        35                  40                  45              


Gln Tyr Gln Gln Met Leu His Thr Asn Leu Val Tyr Leu Ala Thr Ile 
    50                  55                  60                  


Ala Asp Ser Asn Gln Asn Met Gln Ser Leu Leu Pro Ala Pro Pro Thr 
65                  70                  75                  80  


Gln Asn Met Pro Met Gly Pro Gly Gly Met Asn Gln Ser Gly Pro Pro 
                85                  90                  95      


Pro Pro Pro Arg Ser His Asn Met Pro Ser Asp Gly Met Val Gly Gly 
            100                 105                 110         


Gly Pro Pro Ala Pro His Met Gln Asn Gln Met Asn Gly Gln Met Pro 
        115                 120                 125             


Gly Pro Asn His Met Pro Met Gln Gly Pro Gly Pro Asn Gln Leu Asn 
    130                 135                 140                 


Met Thr Asn Ser Ser Met Asn Met Pro Ser Ser Ser His Gly Ser Met 
145                 150                 155                 160 


Gly Gly Tyr Asn His Ser Val Pro Ser Ser Gln Ser Met Pro Val Gln 
                165                 170                 175     


Asn Gln Met Thr Met Ser Gln Gly Gln Pro Met Gly Asn Tyr Gly Pro 
            180                 185                 190         


Arg Pro Asn Met Ser Met Gln Pro Asn Gln Gly Pro Met Met His Gln 
        195                 200                 205             


Gln Pro Pro Ser Gln Gln Tyr Asn Met Pro Gln Gly Gly Gly Gln His 
    210                 215                 220                 


Tyr Gln Gly Gln Gln Pro Pro Met Gly Met Met Gly Gln Val Asn Gln 
225                 230                 235                 240 


Gly Asn His Met Met Gly Gln Arg Gln Ile Pro Pro Tyr Arg Pro Pro 
                245                 250                 255     


Gln Gln Gly Pro Pro Gln Gln Tyr Ser Gly Gln Glu Asp Tyr Tyr Gly 
            260                 265                 270         


Asp Gln Tyr Ser His Gly Gly Gln Gly Pro Pro Glu Gly Met Asn Gln 
        275                 280                 285             


Gln Tyr Tyr Pro Asp Gly Asn Ser Gln Tyr Gly Gln Gln Gln Asp Ala 
    290                 295                 300                 


Tyr Gln Gly Pro Pro Pro Gln Gln Gly Tyr Pro Pro Gln Gln Gln Gln 
305                 310                 315                 320 


Tyr Pro Gly Gln Gln Gly Tyr Pro Gly Gln Gln Gln Gly Tyr Gly Pro 
                325                 330                 335     


Ser Gln Gly Gly Pro Gly Pro Gln Tyr Pro Asn Tyr Pro Gln Gly Gln 
            340                 345                 350         


Gly Gln Gln Tyr Gly Gly Tyr Arg Pro Thr Gln Pro Gly Pro Pro Gln 
        355                 360                 365             


Pro Pro Gln Gln Arg Pro Tyr Gly Tyr Asp Gln Ile Met Pro Lys Lys 
    370                 375                 380                 


Pro Ala Glu Asp Glu Asn Asp Ser Lys Gly Val Ser Glu Ala Ser Gly 
385                 390                 395                 400 


Pro Gln Asn Asp Gly Lys Gln Leu His Pro Pro Gly Lys Ala Asn Ile 
                405                 410                 415     


Ser Glu Lys Ile Asn Lys Arg Ser Gly Pro Lys Arg Gly Lys His Ala 
            420                 425                 430         


Trp Thr His Arg Leu Arg Glu Arg Lys Gln Leu Val Ile Tyr Glu Glu 
        435                 440                 445             


Ile Ser Asp Pro Glu Glu Asp Asp Glu 
    450                 455         


<210> 226
<211> 1374
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 226
atgtctgtgg ctttcgcggc cccgaggcag cgaggcaagg gggagatcac tcccgctgcg       60

attcagaaga tgttggatga caataaccat cttattcagt gtataatgga ctctcagaat      120

aaaggaaaga cctcagagtg ttctcagtat cagcagatgt tgcacacaaa cttggtatac      180

cttgctacaa tagcagattc taatcaaaat atgcagtctc ttttaccagc accacccaca      240

cagaatatgc ctatgggtcc tggagggatg aatcagagcg gccctccccc acctccacgc      300

tctcacaaca tgccttcaga tggaatggta ggtgggggtc ctcctgcacc gcacatgcag      360

aaccagatga acggccagat gcctgggcct aaccatatgc ctatgcaggg acctggaccc      420

aatcaactca atatgacaaa cagttccatg aatatgcctt caagtagcca tggatccatg      480

ggaggttaca accattctgt gccatcatca cagagcatgc cagtacagaa tcagatgaca      540

atgagtcagg gacaaccaat gggaaactat ggtcccagac caaatatgag tatgcagcca      600

aaccaaggtc caatgatgca tcagcagcct ccttctcagc aatacaatat gccacaggga      660

ggcggacagc attaccaagg acagcagcca cctatgggaa tgatgggtca agttaaccaa      720

ggcaatcata tgatgggtca gagacagatt cctccctata gacctcctca acagggccca      780

ccacagcagt actcaggcca ggaagactat tacggggacc aatacagtca tggtggacaa      840

ggtcctccag aaggcatgaa ccagcaatat taccctgatg gaaattcaca gtatggccaa      900

cagcaagatg cataccaggg accacctcca caacagggat atccacccca gcagcagcag      960

tacccagggc agcaaggtta cccaggacag cagcagggct acggtccttc acagggtggt     1020

ccaggtcctc agtatcctaa ctacccacag ggacaaggtc agcagtatgg aggatataga     1080

ccaacacagc ctggaccacc acagccaccc cagcagaggc cttatggata tgaccagatc     1140

atgcccaaga agccagcaga ggacgaaaat gattcgaagg gagtgtcaga agcatctggc     1200

ccacaaaacg atgggaaaca actgcacccc ccaggaaaag caaatatttc tgagaagatt     1260

aataagagat ctggacccaa aagggggaaa catgcctgga cccacagact gcgtgagaga     1320

aagcagctgg tgatttatga agagatcagt gaccctgagg aagatgacga gtaa           1374


<210> 227
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 227
cagtcactga cagttaataa a                                                 21


<210> 228
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 228
cctaaggtta agtcgccctc gctcgagcga gggcgactta accttagg                    48


<210> 229
<211> 22
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Ubiquitinated-Lys

<220>
<221> MOD_RES
<222> (20)..(21)
<223> Ubiquitinated-Lys

<400> 229
Lys Val Thr Ile Ala Gln Gly Gly Val Leu Pro Asn Ile Gln Ala Val 
1               5                   10                  15      


Leu Leu Pro Lys Lys Thr 
            20          


<210> 230
<211> 10
<212> PRT
<213> Homo sapiens

<400> 230
Trp Thr His Arg Leu Arg Glu Arg Lys Gln 
1               5                   10  


<210> 231
<211> 35
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 231
Ser Gly Pro Lys Arg Gly Lys His Ala Trp Thr His Arg Leu Arg Glu 
1               5                   10                  15      


Arg Lys Gln Leu Val Ile Tyr Glu Glu Ile Ser Asp Pro Glu Glu Asp 
            20                  25                  30          


Asp Glu Leu 
        35  


<210> 232
<211> 34
<212> PRT
<213> Homo sapiens

<400> 232
Ser Gly Pro Lys Arg Gly Lys His Ala Trp Thr His Arg Leu Arg Glu 
1               5                   10                  15      


Arg Lys Gln Leu Val Ile Tyr Glu Glu Ile Ser Asp Pro Glu Glu Asp 
            20                  25                  30          


Asp Glu 
        


<210> 233
<211> 34
<212> PRT
<213> Homo sapiens

<400> 233
Ser Gly Pro Lys Arg Gly Glu His Ala Trp Thr His Arg Leu Arg Glu 
1               5                   10                  15      


Arg Lys Gln Leu Val Ile Tyr Glu Glu Ile Ser Asp Pro Glu Glu Asp 
            20                  25                  30          


Asp Glu 
        


<210> 234
<211> 34
<212> PRT
<213> Homo sapiens

<400> 234
Ser Gly Pro Lys Arg Gly Lys His Ala Trp Thr His Arg Leu Arg Glu 
1               5                   10                  15      


Arg Lys Gln Leu Val Val Tyr Glu Glu Ile Ser Asp Pro Glu Glu Asp 
            20                  25                  30          


Asp Glu 
        


<210> 235
<211> 34
<212> PRT
<213> Homo sapiens

<400> 235
Ser Gly Pro Lys Arg Gly Lys His Ala Trp Thr His Arg Val Arg Glu 
1               5                   10                  15      


Arg Lys Gln Leu Val Ile Tyr Glu Glu Ile Ser Asp Pro Gln Glu Asp 
            20                  25                  30          


Asp Glu 
        


<210> 236
<211> 34
<212> PRT
<213> Homo sapiens

<400> 236
Ser Gly Pro Lys Arg Gly Lys His Ala Trp Thr His Arg Leu Arg Glu 
1               5                   10                  15      


Arg Lys Gln Leu Val Ile Tyr Glu Glu Ile Ser Asp Pro Glu Glu Asp 
            20                  25                  30          


Asp Lys 
        


<210> 237
<211> 34
<212> PRT
<213> Homo sapiens

<400> 237
Ser Gly Pro Lys Arg Gly Arg His Ala Trp Thr His Arg Leu Arg Glu 
1               5                   10                  15      


Arg Asn Gln Leu Val Ile Tyr Glu Glu Ile Arg Asp Pro Glu Glu Asp 
            20                  25                  30          


Asp Glu 
        


<210> 238
<211> 36
<212> PRT
<213> Homo sapiens

<400> 238
Lys Leu Glu Leu Arg Arg Lys Glu Thr Glu Gly Lys Met Tyr Ser Leu 
1               5                   10                  15      


Arg Glu Arg Lys Gly His Ala Tyr Lys Glu Ile Ser Glu Pro Gln Asp 
            20                  25                  30          


Asp Asp Tyr Leu 
        35      


<210> 239
<211> 36
<212> PRT
<213> Homo sapiens

<400> 239
Lys Leu Glu Leu Arg Lys Lys Glu Thr Glu Arg Lys Met Tyr Ser Leu 
1               5                   10                  15      


Arg Glu Arg Lys Gly His Ala Tyr Lys Glu Val Ser Glu Pro Gln Asp 
            20                  25                  30          


Asp Asp Tyr Leu 
        35      


<210> 240
<211> 36
<212> PRT
<213> Equus sp.

<400> 240
Lys Leu Glu Leu Arg Arg Lys Glu Val Gly Val Lys Met Tyr Ser Leu 
1               5                   10                  15      


Arg Glu Arg Lys Gly His Ala Tyr Gln Glu Val Ser Glu Pro Gln Asp 
            20                  25                  30          


Asp Asp Tyr Leu 
        35      


<210> 241
<211> 34
<212> PRT
<213> Sarcophilus harrisii

<400> 241
Glu Cys Arg Lys Lys Asp Ala Ala Val His Ile Tyr Asn Leu Arg Glu 
1               5                   10                  15      


Arg Lys Tyr Pro Ile Tyr Gln Glu Ile Trp Asp Pro Gln Asp Asp Asp 
            20                  25                  30          


Tyr Leu 
        


<210> 242
<211> 38
<212> PRT
<213> Salmo salar

<400> 242
Glu Trp Leu Glu Arg Gln Lys Ala Leu Asn Thr Tyr Lys Arg Gly Arg 
1               5                   10                  15      


Asn Leu Arg Asp Arg Pro Arg Ile Thr Tyr Thr Glu Glu Glu Val Pro 
            20                  25                  30          


Lys Asp Asp His Tyr Leu 
        35              


<210> 243
<211> 36
<212> PRT
<213> Esox lucius

<400> 243
Leu Arg Gly Gln Thr Gln Asp Leu Asn Tyr Gln His Gly Lys Asn Leu 
1               5                   10                  15      


Arg Asp Arg Thr Arg Val Ser Tyr Ile Glu Glu Glu Glu Pro Lys Asp 
            20                  25                  30          


Asp His Phe Leu 
        35      


<210> 244
<211> 39
<212> PRT
<213> Homo sapiens

<400> 244
Glu Leu Arg Arg Lys Glu Thr Glu Gly Lys Met Tyr Ser Leu Arg Glu 
1               5                   10                  15      


Arg Lys Gly His Ala Tyr Lys Glu Ile Ser Glu Pro Gln Asp Asp Asp 
            20                  25                  30          


Tyr Leu Tyr Cys Glu Met Cys 
        35                  


