﻿               SEQUENCE LISTING

<110> Hacettepe Üniversitesi

<120> BIOMARKER PANEL SPECIFIC TO MYELOID-DERIVED SUPPRESSIVE CELLS 

<130> P21-0119

<150> TR2020/03833
<151> 2020-03-12

<160> 31

<170> BiSSAP 1.3.6

<210> 1
<211> 20
<212> DNA
<213> Artificial Sequence


<220> 
<223> CD1d tv1 sense primer

<400> 1
tcgtcctcta ctggggtggg                                                20


<210> 2
<211> 24
<212> DNA
<213> Artificial Sequence


<220> 
<223> CD1d tv1 anti-sense primer

<400> 2
gccctgatag gaagtttgcc tctt                                           24


<210> 3
<211> 21
<212> DNA
<213> Artificial Sequence


<220> 
<223> CD33 tv2 sense primer

<400> 3
cctgctgtgg gcagacttga c                                              21


<210> 4
<211> 20
<212> DNA
<213> Artificial Sequence


<220> 
<223> CD33 tv2 anti-sense primer

<400> 4
ggccgtgggg tgattatgag                                                20


<210> 5
<211> 20
<212> DNA
<213> Artificial Sequence


<220> 
<223> CD16 tv1 sense primer

<400> 5
aaatccagga gatgggggca                                                20


<210> 6
<211> 23
<212> DNA
<213> Artificial Sequence


<220> 
<223> CD16 tv1 anti-sense primer

<400> 6
ctttgggaga tcttcagtcc gca                                            23


<210> 7
<211> 20
<212> DNA
<213> Artificial Sequence


<220> 
<223> CD16 tv2 sense primer

<400> 7
gtaacacgag gaagggctcc                                                20


<210> 8
<211> 19
<212> DNA
<213> Artificial Sequence


<220> 
<223> CD16 tv2 anti-sense primer

<400> 8
gcctggcttg agatgaggt                                                 19


<210> 9
<211> 20
<212> DNA
<213> Artificial Sequence


<220> 
<223> CD16 tv3 sense primer

<400> 9
catgcggact gatctcccaa                                                20


<210> 10
<211> 19
<212> DNA
<213> Artificial Sequence


<220> 
<223> CD16 tv3 anti-sense primer

<400> 10
gcctggcttg agatgaggt                                                 19


<210> 11
<211> 24
<212> DNA
<213> Artificial Sequence


<220> 
<223> CD1d tv2 sense primer

<400> 11
ctgaagaagc aaggtgggag ctac                                           24


<210> 12
<211> 24
<212> DNA
<213> Artificial Sequence


<220> 
<223> CD1d tv2 anti-sense primer

<400> 12
gccctgatag gaagtttgcc tctt                                           24


<210> 13
<211> 20
<212> DNA
<213> Artificial Sequence


<220> 
<223> CD44 tv1 sense primer

<400> 13
gaatccctgc taccactttg                                                20


<210> 14
<211> 22
<212> DNA
<213> Artificial Sequence


<220> 
<223> CD44 tv1 anti-sense primer

<400> 14
ggtatttgaa gacgtaccag cc                                             22


<210> 15
<211> 21
<212> DNA
<213> Artificial Sequence


<220> 
<223> CD44 tv2 sense primer

<400> 15
gaccaattac cataactatt g                                              21


<210> 16
<211> 21
<212> DNA
<213> Artificial Sequence


<220> 
<223> CD44 tv2 anti-sense primer

<400> 16
tatttgaaga cgtactggta g                                              21


<210> 17
<211> 3795
<212> RNA
<213> Homo sapiens


<220> 
<223> CD1d transcript variant 1 mRNA

<400> 17
gttttctacc caagaatgct acttcaggag atcagtcaaa aggttagggt gatggtgacg       60

gtggaaatat agaaaaagga atttattcaa gaggtattca aaaagaagtg aaatagagat      120

gagttggaga tagattggat aaaaagagtg agggagaggg aggtgtcagg ctgcagccca      180

ggttctgagt tgccaaagag gagtcttttc ctccaggaaa ttgagacacg ccggttgtga      240

aacctactga agtgagcggc ggcgccagga ttcctgggac cccgacctct ttgcagctcg      300

cacagctaag ggcgagggcg cccttcggca gaagcagcaa accgccggca agcccagcga      360

ggagggctgc cggggtctgg gcttgggaat tggctggcac ccagcggaaa gggacgtgag      420

ctgagcggcg ggggagaaga gtgcgcaggt cagagggcgg cgcgcagcgg cgctccgcga      480

ggtccccacg ccgggcgata tggggtgcct gctgtttctg ctgctctggg cgctcctcca      540

ggcttgggga agcgctgaag tcccgcaaag gcttttcccc ctccgctgcc tccagatctc      600

gtccttcgcc aatagcagct ggacgcgcac cgacggcttg gcgtggctgg gggagctgca      660

gacgcacagc tggagcaacg actcggacac cgtccgctct ctgaagcctt ggtcccaggg      720

cacgttcagc gaccagcagt gggagacgct gcagcatata tttcgggttt atcgaagcag      780

cttcaccagg gacgtgaagg aattcgccaa aatgctacgc ttatcctatc ccttggagct      840

ccaggtgtcc gctggctgtg aggtgcaccc tgggaacgcc tcaaataact tcttccatgt      900

agcatttcaa ggaaaagata tcctgagttt ccaaggaact tcttgggagc caacccaaga      960

ggccccactt tgggtaaact tggccattca agtgctcaac caggacaagt ggacgaggga     1020

aacagtgcag tggctcctta atggcacctg cccccaattt gtcagtggcc tccttgagtc     1080

agggaagtcg gaactgaaga agcaagtgaa gcccaaggcc tggctgtccc gtggccccag     1140

tcctggccct ggccgtctgc tgctggtgtg ccatgtctca ggattctacc caaagcctgt     1200

atgggtgaag tggatgcggg gtgagcagga gcagcagggc actcagccag gggacatcct     1260

gcccaatgct gacgagacat ggtatctccg agcaaccctg gatgtggtgg ctggggaggc     1320

agctggcctg tcctgtcggg tgaagcacag cagtctagag ggccaggaca tcgtcctcta     1380

ctggggtggg agctacacct ccatgggctt gattgccttg gcagtcctgg cgtgcttgct     1440

gttcctcctc attgtgggct ttacctcccg gtttaagagg caaacttcct atcagggcgt     1500

cctgtgactc gccttgccac atctgtgtct ctggaaccca ggacctctgg acctcaggtt     1560

cctaagactt cagtcctggt ctgctcagga attgaagatg taaggaattg aagataggag     1620

agataccttg aaaaagtaga gaacagtcat gaggcagctt tcatcacacc cttttaacat     1680

ttatctaaaa gaatttaaat tctttttcaa aaattacact acaagtttat aagcccaaat     1740

ggctctgtga aatcagaagt gcaaaggtgt gcaaacttgt atctgaagac ctaccaggga     1800

caagcaggta agagctgatg tgagtgtgtg tgatgggatc tgtaaggaac tggaacacac     1860

atgtcctatc caaaggaatc agctgcagct gcttgttgtc aagtataaag tcaggacctg     1920

gcttggcttt aaccgttttt caagaaaact ggaaatctgg attttcagcg aacatgcctg     1980

attttaaaag gttgactcaa gtttttacaa aatactatgt gggacacctc aaatacatac     2040

ctactgactg atgacaaacc caggagtttg tgtgtctttt ataaaaagtt tgccctggat     2100

gtcatattgg cagttggagg acacagtttc tattgtaaat ttggatttac gactgaagaa     2160

ggacattttc tctttaaaag aaagttaggt tataagaaac agaggcgtct cacattttta     2220

cttggtgtaa ttaataaacg aagataaatc atagtgtatg tgtattatgt tgaaaaaaac     2280

tactctgagt aaggatattt ctctcaaatg gtcatcactt tttttccttg gaggaagatt     2340

gtcatgaagg catcccttcc ttcccaaaac gacaacggca acaacaacag tctcctttac     2400

ttacagctat taaaagagac aatgtaggga aagggccaac accacttggg caagcatgag     2460

ctgcagcgat gatggtgatg gtagcccagc catgctgtgt tcttatctta gagaggacag     2520

agcaggaaac ttacaggggt agcagacctt tctgatgcca aagaaataag gaggccaaaa     2580

tcatgtttgc ctagctggga ggtaaatctc ttggcagtca gggtccctga acacccagaa     2640

aaaataagtg agacttaacg gttggagagt gtttgcttga gaaaagtaac atttcacact     2700

ctctatacta gacttgcaca tatgaattta ggatgtgcgt gaagattctg ctagcttcaa     2760

catatcccaa agcacttgga tatgcctata atccaagtgc tttgggaggc tgagatagga     2820

ggattgttta aggccaggca tttgaaatca gcctgggcaa catagtgaga ccctgtctct     2880

acaaaaaatt aaaaaactag ccacccatgg tggtgagcgc ctgtagtcct agctactctg     2940

gaggctgagg tgggaggatc ccttgagccc atgaattcca ggttagtgtg agctgtgatt     3000

gtgtcactac agtgtaagga tgacagaggg agaccctgtc ttaaaaaaaa attatgctag     3060

cttttaaatc aatggttccc aaattgtagt aacctgacca acagcctcag caggacctgg     3120

gaacttgtta taaatgcaaa ttgttttggg cctcatccta tacccgctga atgagaaact     3180

ctgagtctgg aagcaggctc aatagtcaag ccccctggtg attctgatgc ttagctaaag     3240

ttagagaacc actgttctta gacattgtgc aatgttatac aacaacttcc tcaaagtgct     3300

aagtgaaaag gacattggcc tggcgttagt cagggaaggc gtcctggagg gaggggaatt     3360

tgaagcagag ctttgaaaaa caaaggcagt gaggtgaacc agcaagtgca ctggctgagg     3420

ggactggagt tctagcctct gaaccagttt cctcctgtgc caaaggagga taataattat     3480

ctattattga ttatctccta gacttgtgga gttcaagtgt gtaatgcctt aaaagatgtg     3540

gaggctgttg ctgtgtttgg taccacattg cccaccctca cgtggcgctc ttcagcttag     3600

gttcctctag cagtgtcaag tttgtgaacc aaccccactg gccttctgca ttctgagggc     3660

acgtgtgtta aagtctctac tgatgtcctt ttggaaatgc ctctgcatga atttatggta     3720

gctctgactc atctttaaac aattttaatt tatttagaaa ataaaggctt atctctccag     3780

gaaaaaaaaa aaaaa                                                      3795


<210> 18
<211> 335
<212> PRT
<213> Homo sapiens


<220> 
<223> CD1d transcript variant 1 amino acid sequence

<400> 18
Met Gly Cys Leu Leu Phe Leu Leu Leu Trp Ala Leu Leu Gln Ala Trp 
1               5                   10                  15      
Gly Ser Ala Glu Val Pro Gln Arg Leu Phe Pro Leu Arg Cys Leu Gln 
            20                  25                  30          
Ile Ser Ser Phe Ala Asn Ser Ser Trp Thr Arg Thr Asp Gly Leu Ala 
        35                  40                  45              
Trp Leu Gly Glu Leu Gln Thr His Ser Trp Ser Asn Asp Ser Asp Thr 
    50                  55                  60                  
Val Arg Ser Leu Lys Pro Trp Ser Gln Gly Thr Phe Ser Asp Gln Gln 
65                  70                  75                  80  
Trp Glu Thr Leu Gln His Ile Phe Arg Val Tyr Arg Ser Ser Phe Thr 
                85                  90                  95      
Arg Asp Val Lys Glu Phe Ala Lys Met Leu Arg Leu Ser Tyr Pro Leu 
            100                 105                 110         
Glu Leu Gln Val Ser Ala Gly Cys Glu Val His Pro Gly Asn Ala Ser 
        115                 120                 125             
Asn Asn Phe Phe His Val Ala Phe Gln Gly Lys Asp Ile Leu Ser Phe 
    130                 135                 140                 
Gln Gly Thr Ser Trp Glu Pro Thr Gln Glu Ala Pro Leu Trp Val Asn 
145                 150                 155                 160 
Leu Ala Ile Gln Val Leu Asn Gln Asp Lys Trp Thr Arg Glu Thr Val 
                165                 170                 175     
Gln Trp Leu Leu Asn Gly Thr Cys Pro Gln Phe Val Ser Gly Leu Leu 
            180                 185                 190         
Glu Ser Gly Lys Ser Glu Leu Lys Lys Gln Val Lys Pro Lys Ala Trp 
        195                 200                 205             
Leu Ser Arg Gly Pro Ser Pro Gly Pro Gly Arg Leu Leu Leu Val Cys 
    210                 215                 220                 
His Val Ser Gly Phe Tyr Pro Lys Pro Val Trp Val Lys Trp Met Arg 
225                 230                 235                 240 
Gly Glu Gln Glu Gln Gln Gly Thr Gln Pro Gly Asp Ile Leu Pro Asn 
                245                 250                 255     
Ala Asp Glu Thr Trp Tyr Leu Arg Ala Thr Leu Asp Val Val Ala Gly 
            260                 265                 270         
Glu Ala Ala Gly Leu Ser Cys Arg Val Lys His Ser Ser Leu Glu Gly 
        275                 280                 285             
Gln Asp Ile Val Leu Tyr Trp Gly Gly Ser Tyr Thr Ser Met Gly Leu 
    290                 295                 300                 
Ile Ala Leu Ala Val Leu Ala Cys Leu Leu Phe Leu Leu Ile Val Gly 
305                 310                 315                 320 
Phe Thr Ser Arg Phe Lys Arg Gln Thr Ser Tyr Gln Gly Val Leu 
                325                 330                 335 

<210> 19
<211> 1081
<212> RNA
<213> Homo sapiens


<220> 
<223> CD33 transcript variant 2 mRNA

<400> 19
ctgctcacac aggaagccct ggaagctgct tcctcagaca tgccgctgct gctactgctg      60

cccctgctgt gggcagactt gacccacagg cccaaaatcc tcatccctgg cactctagaa     120

cccggccact ccaaaaacct gacctgctct gtgtcctggg cctgtgagca gggaacaccc     180

ccgatcttct cctggttgtc agctgccccc acctccctgg gccccaggac tactcactcc     240

tcggtgctca taatcacccc acggccccag gaccacggca ccaacctgac ctgtcaggtg     300

aagttcgctg gagctggtgt gactacggag agaaccatcc agctcaacgt cacctatgtt     360

ccacagaacc caacaactgg tatctttcca ggagatggct cagggaaaca agagaccaga     420

gcaggagtgg ttcatggggc cattggagga gctggtgtta cagccctgct cgctctttgt     480

ctctgcctca tcttcttcat agtgaagacc cacaggagga aagcagccag gacagcagtg     540

ggcaggaatg acacccaccc taccacaggg tcagcctccc cgaaacacca gaagaagtcc     600

aagttacatg gccccactga aacctcaagc tgttcaggtg ccgcccctac tgtggagatg     660

gatgaggagc tgcattatgc ttccctcaac tttcatggga tgaatccttc caaggacacc     720

tccaccgaat actcagaggt caggacccag tgaggaaccc acaagagcat caggctcagc     780

tagaagatcc acatcctcta caggtcgggg accaaaggct gattcttgga gatttaacac     840

cccacaggca atgggtttat agacattatg tgagtttcct gctatattaa catcatctta     900

gactttgcaa gcagagagtc gtggaatcaa atctgtgctc tttcatttgc taagtgtatg     960

atgtcacaca agctccttaa ccttccatgt ctccattttc ttctctgtga agtaggtata    1020

agaagtccta tctcataggg atgctgtgag cattaaataa aggtacacat ggaaaacacc    1080

a                                                                    1081


<210> 20
<211> 237
<212> PRT
<213> Homo sapiens


<220> 
<223> CD33 transcript variant 2 amino acid sequence

<400> 20
Met Pro Leu Leu Leu Leu Leu Pro Leu Leu Trp Ala Asp Leu Thr His 
1               5                   10                  15      
Arg Pro Lys Ile Leu Ile Pro Gly Thr Leu Glu Pro Gly His Ser Lys 
            20                  25                  30          
Asn Leu Thr Cys Ser Val Ser Trp Ala Cys Glu Gln Gly Thr Pro Pro 
        35                  40                  45              
Ile Phe Ser Trp Leu Ser Ala Ala Pro Thr Ser Leu Gly Pro Arg Thr 
    50                  55                  60                  
Thr His Ser Ser Val Leu Ile Ile Thr Pro Arg Pro Gln Asp His Gly 
65                  70                  75                  80  
Thr Asn Leu Thr Cys Gln Val Lys Phe Ala Gly Ala Gly Val Thr Thr 
                85                  90                  95      
Glu Arg Thr Ile Gln Leu Asn Val Thr Tyr Val Pro Gln Asn Pro Thr 
            100                 105                 110         
Thr Gly Ile Phe Pro Gly Asp Gly Ser Gly Lys Gln Glu Thr Arg Ala 
        115                 120                 125             
Gly Val Val His Gly Ala Ile Gly Gly Ala Gly Val Thr Ala Leu Leu 
    130                 135                 140                 
Ala Leu Cys Leu Cys Leu Ile Phe Phe Ile Val Lys Thr His Arg Arg 
145                 150                 155                 160 
Lys Ala Ala Arg Thr Ala Val Gly Arg Asn Asp Thr His Pro Thr Thr 
                165                 170                 175     
Gly Ser Ala Ser Pro Lys His Gln Lys Lys Ser Lys Leu His Gly Pro 
            180                 185                 190         
Thr Glu Thr Ser Ser Cys Ser Gly Ala Ala Pro Thr Val Glu Met Asp 
        195                 200                 205             
Glu Glu Leu His Tyr Ala Ser Leu Asn Phe His Gly Met Asn Pro Ser 
    210                 215                 220                 
Lys Asp Thr Ser Thr Glu Tyr Ser Glu Val Arg Thr Gln 
225                 230                 235         

<210> 21
<211> 2103
<212> RNA
<213> Homo sapiens


<220> 
<223> CD16 transcript variant 1 mRNA

<400> 21
gtttactccc tcctgtctag tcggcttggt ccctttaggg ctccggatat ctttggtgac      60

ttgtccactc cagtgtggca tcatgtggca gctgctcctc ccaactgctc tgctacttct     120

agtttcagct ggcatgcgga ctgaagatct cccaaaggct gtggtgttcc tggagcctca     180

atggtacagc gtgcttgaga aggacagtgt gactctgaag tgccagggag cctactcccc     240

tgaggacaat tccacacagt ggtttcacaa tgagaacctc atctcaagcc aggcctcgag     300

ctacttcatt gacgctgcca cagtcaacga cagtggagag tacaggtgcc agacaaacct     360

ctccaccctc agtgacccgg tgcagctaga agtccatatc ggctggctgt tgctccaggc     420

ccctcggtgg gtgttcaagg aggaagaccc tattcacctg aggtgtcaca gctggaagaa     480

cactgctctg cataaggtca catatttaca gaatggcaaa gacaggaagt attttcatca     540

taattctgac ttccacattc caaaagccac actcaaagat agcggctcct acttctgcag     600

ggggcttgtt gggagtaaaa atgtgtcttc agagactgtg aacatcacca tcactcaagg     660

tttggcagtg tcaaccatct catcattctc tccacctggg taccaagtct ctttctgctt     720

ggtgatggta ctcctttttg cagtggacac aggactatat ttctctgtga agacaaacat     780

ttgaagctca acaagagact ggaaggacca taaacttaaa tggagaaagg accctcaaga     840

cacatgaccc ccatcccatg ggggtaataa gagcagtggc agcagcatct ctgaacattt     900

ctctggattt gcaaccccat catcctcagg cctctctaca agcagcagga aacatagaac     960

tcagagccag atcctttatc caactctcga tttttccttg gtctccagtg gaagggaaaa    1020

gcccatgatc ttcaagcagg gaagccccag tgagtagctg cattcctaga aattgaagtt    1080

tcagagctac acaaacactt tttctgtccc aaccattccc tcacagcaaa gcaacaatac    1140

aggctaggga tggtaatcct ttaaacatac aaaaattgct cgtattataa attacccagt    1200

ttagagggaa aaaaagaaaa taattattcc taaacaaatg gataagtaga attaatggtt    1260

gaggcaggac cctacagagt gtgggaactg ctggggatct agagaattca gtgggaccaa    1320

tgaaagcatg gctgagaaat agcagggtag tccaggatag tctaagggag gtgttcccat    1380

ctgagcccag agataagggt gtcttcctag aacattagcc gtagtggaat taacaggaaa    1440

tcatgagggt gacgtagaat tgagtcttcc aggggactct atcagaactg gaccatttcc    1500

aagtatataa cgatgagtcc tctaatgcta ggagtagaaa atggtcctag gaaggggact    1560

gaggattggg gtgggggtgg ggtggaaaag aaagtacaga acaaaccctg tgtcactgtc    1620

tcaagttaag ctaagtgaac agaactatct cagcatcaga atgagaaagc ctgagaagaa    1680

agaaccaacc agaagcacac aggaaggaaa gcgcaggagg tgaaaatgct ttcttggccg    1740

gggtagtaag aattagaggt taatgcaggg actgtaaaac caccttttct gcttcaatgt    1800

ctagttcctg tatagctttg ttcattgcat ttattaaaca aatgttgtat aaccaatact    1860

aaatgtacta ctgagcttca ctgagttacg ctgtgaaact ttcaaatcct tcttcatgtc    1920

agttccaatg aggtggggat ggagaagaca attgttgctt atgaaagaaa gctttagctg    1980

tctctgtttt gtaagctttc agtgcaacat ttcttggttc caataaagca ttttacaaga    2040

tcttgcatgc tactcttaga tagaagatgg caaaaccatg gtaataaaat atgaatgata    2100

aaa                                                                  2103


<210> 22
<211> 233
<212> PRT
<213> Homo sapiens


<220> 
<223> CD16 transcript variant 2 amino acid sequence

<400> 22
Met Trp Gln Leu Leu Leu Pro Thr Ala Leu Leu Leu Leu Val Ser Ala 
1               5                   10                  15      
Gly Met Arg Thr Glu Asp Leu Pro Lys Ala Val Val Phe Leu Glu Pro 
            20                  25                  30          
Gln Trp Tyr Ser Val Leu Glu Lys Asp Ser Val Thr Leu Lys Cys Gln 
        35                  40                  45              
Gly Ala Tyr Ser Pro Glu Asp Asn Ser Thr Gln Trp Phe His Asn Glu 
    50                  55                  60                  
Asn Leu Ile Ser Ser Gln Ala Ser Ser Tyr Phe Ile Asp Ala Ala Thr 
65                  70                  75                  80  
Val Asn Asp Ser Gly Glu Tyr Arg Cys Gln Thr Asn Leu Ser Thr Leu 
                85                  90                  95      
Ser Asp Pro Val Gln Leu Glu Val His Ile Gly Trp Leu Leu Leu Gln 
            100                 105                 110         
Ala Pro Arg Trp Val Phe Lys Glu Glu Asp Pro Ile His Leu Arg Cys 
        115                 120                 125             
His Ser Trp Lys Asn Thr Ala Leu His Lys Val Thr Tyr Leu Gln Asn 
    130                 135                 140                 
Gly Lys Asp Arg Lys Tyr Phe His His Asn Ser Asp Phe His Ile Pro 
145                 150                 155                 160 
Lys Ala Thr Leu Lys Asp Ser Gly Ser Tyr Phe Cys Arg Gly Leu Val 
                165                 170                 175     
Gly Ser Lys Asn Val Ser Ser Glu Thr Val Asn Ile Thr Ile Thr Gln 
            180                 185                 190         
Gly Leu Ala Val Ser Thr Ile Ser Ser Phe Ser Pro Pro Gly Tyr Gln 
        195                 200                 205             
Val Ser Phe Cys Leu Val Met Val Leu Leu Phe Ala Val Asp Thr Gly 
    210                 215                 220                 
Leu Tyr Phe Ser Val Lys Thr Asn Ile 
225                 230             

<210> 23
<211> 2148
<212> RNA
<213> Homo sapiens


<220> 
<223> CD16 transcript variant 2 mRNA

<400> 23
aggctgacag accagcccag atccagtggc ccggaggggc ctgagctaaa tccgcaggac      60

ctgggtaaca cgaggaaggg ctccggatat ctttggtgac ttgtccactc cagtgtggca     120

tcatgtggca gctgctcctc ccaactgctc tgctacttct agtttcagct ggcatgcgga     180

ctgaagatct cccaaaggct gtggtgttcc tggagcctca atggtacagc gtgcttgaga     240

aggacagtgt gactctgaag tgccagggag cctactcccc tgaggacaat tccacacagt     300

ggtttcacaa tgagaacctc atctcaagcc aggcctcgag ctacttcatt gacgctgcca     360

cagtcaacga cagtggagag tacaggtgcc agacaaacct ctccaccctc agtgacccgg     420

tgcagctaga agtccatatc ggctggctgt tgctccaggc ccctcggtgg gtgttcaagg     480

aggaagaccc tattcacctg aggtgtcaca gctggaagaa cactgctctg cataaggtca     540

catatttaca gaatggcaaa gacaggaagt attttcatca taattctgac ttccacattc     600

caaaagccac actcaaagat agcggctcct acttctgcag ggggcttgtt gggagtaaaa     660

atgtgtcttc agagactgtg aacatcacca tcactcaagg tttggcagtg tcaaccatct     720

catcattctc tccacctggg taccaagtct ctttctgctt ggtgatggta ctcctttttg     780

cagtggacac aggactatat ttctctgtga agacaaacat ttgaagctca acaagagact     840

ggaaggacca taaacttaaa tggagaaagg accctcaaga caaatgaccc ccatcccatg     900

ggggtaataa gagcagtggc agcagcatct ctgaacattt ctctggattt gcaaccccat     960

catcctcagg cctctctaca agcagcagga aacatagaac tcagagccag atcctttatc    1020

caactctcga tttttccttg gtctccagtg gaagggaaaa gcccatgatc ttcaagcagg    1080

gaagccccag tgagtagctg cattcctaga aattgaagtt tcagagctac acaaacactt    1140

tttctgtccc aaccattccc tcacagcaaa gcaacaatac aggctaggga tggtaatcct    1200

ttaaacatac aaaaattgct cgtattataa attacccagt ttagagggaa aaaaagaaaa    1260

taattattcc taaacaaatg gataagtaga attaatggtt gaggcaggac cctacagagt    1320

gtgggaactg ctggggatct agagaattca gtgggaccaa tgaaagcatg gctgagaaat    1380

agcagggtag tccaggatag tctaagggag gtgttcccat ctgagcccag agataagggt    1440

gtcttcctag aacattagcc gtagtggaat taacaggaaa tcatgagggt gacgtagaat    1500

tgagtcttcc aggggactct atcagaactg gaccatttcc aagtatataa cgatgagtcc    1560

tctaatgcta ggagtagaaa atggtcctag gaaggggact gaggattggg gtgggggtgg    1620

ggtggaaaag aaagtacaga acaaaccctg tgtcactgtc tcaagttaag ctaagtgaac    1680

agaactatct cagcatcaga atgagaaagc ctgagaagaa agaaccaacc agaagcacac    1740

aggaaggaaa gcgcaggagg tgaaaatgct ttcttggccg gggtagtaag aattagaggt    1800

taatgcaggg actgtaaaac caccttttct gcttcaatgt ctagttcctg tatagctttg    1860

ttcattgcat ttattaaaca aatgttgtat aaccaatact aaatgtacta ctgagcttca    1920

ctgagttacg ctgtgaaact ttcaaatcct tcttcatgtc agttccaatg aggtggggat    1980

ggagaagaca attgttgctt atgaaagaaa gctttagctg tctctgtttt gtaagctttc    2040

agtgcaacat ttcttggttc caataaagca ttttacaaga tcttgcatgc tactcttaga    2100

tagaagatgg caaaaccatg gtaataaaat atgaatgata aaaaaaaa                 2148


<210> 24
<211> 2100
<212> RNA
<213> Homo sapiens


<220> 
<223> CD16 transcript variant 3 mRNA

<400> 24
gtttactccc tcctgtctag tcggcttggt ccctttaggg ctccggatat ctttggtgac      60

ttgtccactc cagtgtggca tcatgtggca gctgctcctc ccaactgctc tgctacttct     120

agtttcagct ggcatgcgga ctgatctccc aaaggctgtg gtgttcctgg agcctcaatg     180

gtacagcgtg cttgagaagg acagtgtgac tctgaagtgc cagggagcct actcccctga     240

ggacaattcc acacagtggt ttcacaatga gaacctcatc tcaagccagg cctcgagcta     300

cttcattgac gctgccacag tcaacgacag tggagagtac aggtgccaga caaacctctc     360

caccctcagt gacccggtgc agctagaagt ccatatcggc tggctgttgc tccaggcccc     420

tcggtgggtg ttcaaggagg aagaccctat tcacctgagg tgtcacagct ggaagaacac     480

tgctctgcat aaggtcacat atttacagaa tggcaaagac aggaagtatt ttcatcataa     540

ttctgacttc cacattccaa aagccacact caaagatagc ggctcctact tctgcagggg     600

gcttgttggg agtaaaaatg tgtcttcaga gactgtgaac atcaccatca ctcaaggttt     660

ggcagtgtca accatctcat cattctctcc acctgggtac caagtctctt tctgcttggt     720

gatggtactc ctttttgcag tggacacagg actatatttc tctgtgaaga caaacatttg     780

aagctcaaca agagactgga aggaccataa acttaaatgg agaaaggacc ctcaagacac     840

atgaccccca tcccatgggg gtaataagag cagtggcagc agcatctctg aacatttctc     900

tggatttgca accccatcat cctcaggcct ctctacaagc agcaggaaac atagaactca     960

gagccagatc ctttatccaa ctctcgattt ttccttggtc tccagtggaa gggaaaagcc    1020

catgatcttc aagcagggaa gccccagtga gtagctgcat tcctagaaat tgaagtttca    1080

gagctacaca aacacttttt ctgtcccaac cattccctca cagcaaagca acaatacagg    1140

ctagggatgg taatccttta aacatacaaa aattgctcgt attataaatt acccagttta    1200

gagggaaaaa aagaaaataa ttattcctaa acaaatggat aagtagaatt aatggttgag    1260

gcaggaccct acagagtgtg ggaactgctg gggatctaga gaattcagtg ggaccaatga    1320

aagcatggct gagaaatagc agggtagtcc aggatagtct aagggaggtg ttcccatctg    1380

agcccagaga taagggtgtc ttcctagaac attagccgta gtggaattaa caggaaatca    1440

tgagggtgac gtagaattga gtcttccagg ggactctatc agaactggac catttccaag    1500

tatataacga tgagtcctct aatgctagga gtagaaaatg gtcctaggaa ggggactgag    1560

gattggggtg ggggtggggt ggaaaagaaa gtacagaaca aaccctgtgt cactgtctca    1620

agttaagcta agtgaacaga actatctcag catcagaatg agaaagcctg agaagaaaga    1680

accaaccaga agcacacagg aaggaaagcg caggaggtga aaatgctttc ttggccgggg    1740

tagtaagaat tagaggttaa tgcagggact gtaaaaccac cttttctgct tcaatgtcta    1800

gttcctgtat agctttgttc attgcattta ttaaacaaat gttgtataac caatactaaa    1860

tgtactactg agcttcactg agttacgctg tgaaactttc aaatccttct tcatgtcagt    1920

tccaatgagg tggggatgga gaagacaatt gttgcttatg aaagaaagct ttagctgtct    1980

ctgttttgta agctttcagt gcaacatttc ttggttccaa taaagcattt tacaagatct    2040

tgcatgctac tcttagatag aagatggcaa aaccatggta ataaaatatg aatgataaaa    2100


<210> 25
<211> 232
<212> PRT
<213> Homo sapiens


<220> 
<223> CD16 transcript variant 3 amino acid sequence

<400> 25
Met Trp Gln Leu Leu Leu Pro Thr Ala Leu Leu Leu Leu Val Ser Ala 
1               5                   10                  15      
Gly Met Arg Thr Asp Leu Pro Lys Ala Val Val Phe Leu Glu Pro Gln 
            20                  25                  30          
Trp Tyr Ser Val Leu Glu Lys Asp Ser Val Thr Leu Lys Cys Gln Gly 
        35                  40                  45              
Ala Tyr Ser Pro Glu Asp Asn Ser Thr Gln Trp Phe His Asn Glu Asn 
    50                  55                  60                  
Leu Ile Ser Ser Gln Ala Ser Ser Tyr Phe Ile Asp Ala Ala Thr Val 
65                  70                  75                  80  
Asn Asp Ser Gly Glu Tyr Arg Cys Gln Thr Asn Leu Ser Thr Leu Ser 
                85                  90                  95      
Asp Pro Val Gln Leu Glu Val His Ile Gly Trp Leu Leu Leu Gln Ala 
            100                 105                 110         
Pro Arg Trp Val Phe Lys Glu Glu Asp Pro Ile His Leu Arg Cys His 
        115                 120                 125             
Ser Trp Lys Asn Thr Ala Leu His Lys Val Thr Tyr Leu Gln Asn Gly 
    130                 135                 140                 
Lys Asp Arg Lys Tyr Phe His His Asn Ser Asp Phe His Ile Pro Lys 
145                 150                 155                 160 
Ala Thr Leu Lys Asp Ser Gly Ser Tyr Phe Cys Arg Gly Leu Val Gly 
                165                 170                 175     
Ser Lys Asn Val Ser Ser Glu Thr Val Asn Ile Thr Ile Thr Gln Gly 
            180                 185                 190         
Leu Ala Val Ser Thr Ile Ser Ser Phe Ser Pro Pro Gly Tyr Gln Val 
        195                 200                 205             
Ser Phe Cys Leu Val Met Val Leu Leu Phe Ala Val Asp Thr Gly Leu 
    210                 215                 220                 
Tyr Phe Ser Val Lys Thr Asn Ile 
225                 230         

<210> 26
<211> 3213
<212> DNA
<213> Homo sapiens


<220> 
<223> CD1d transcript variant 2 mRNA

<400> 26
gcagctcgca cagctaaggg cgagggcgcc cttcggcaga agcagcaaac cgccggcaag       60

cccagcgagg agggctgccg gggtctgggc ttgggaattg gctggcaccc agcggaaagg      120

gacgtgagct gagcggcggg ggagaagagt gcgcaggtca gagggcggcg cgcagcggcg      180

ctccgcgagg tccccacgcc gggcgatatg gggtgcctgc tgtttctgct gctctgggcg      240

ctcctccagg cttggggaag cgctgaagtc ccgcaaaggc ttttccccct ccgctgcctc      300

cagatctcgt ccttcgccaa tagcagctgg acgcgcaccg acggcttggc gtggctgggg      360

gagctgcaga cgcacagctg gagcaacgac tcggacaccg tccgctctct gaagccttgg      420

tcccagggca cgttcagcga ccagcagtgg gagacgctgc agcatatatt tcgggtttat      480

cgaagcagct tcaccaggga cgtgaaggaa ttcgccaaaa tgctacgctt atcctatccc      540

ttggagctcc aggtgtccgc tggctgtgag gtgcaccctg ggaacgcctc aaataacttc      600

ttccatgtag catttcaagg aaaagatatc ctgagtttcc aaggaacttc ttgggagcca      660

acccaagagg ccccactttg ggtaaacttg gccattcaag tgctcaacca ggacaagtgg      720

acgagggaaa cagtgcagtg gctccttaat ggcacctgcc cccaatttgt cagtggcctc      780

cttgagtcag ggaagtcgga actgaagaag caaggtggga gctacacctc catgggcttg      840

attgccttgg cagtcctggc gtgcttgctg ttcctcctca ttgtgggctt tacctcccgg      900

tttaagaggc aaacttccta tcagggcgtc ctgtgactcg ccttgccaca tctgtgtctc      960

tggaacccag gacctctgga cctcaggttc ctaagacttc agtcctggtc tgctcaggaa     1020

ttgaagatgt aaggaattga agataggaga gataccttga aaaagtagag aacagtcatg     1080

aggcagcttt catcacaccc ttttaacatt tatctaaaag aatttaaatt ctttttcaaa     1140

aattacacta caagtttata agcccaaatg gctctgtgaa atcagaagtg caaaggtgtg     1200

caaacttgta tctgaagacc taccagggac aagcaggtaa gagctgatgt gagtgtgtgt     1260

gatgggatct gtaaggaact ggaacacaca tgtcctatcc aaaggaatca gctgcagctg     1320

cttgttgtca agtataaagt caggacctgg cttggcttta accgtttttc aagaaaactg     1380

gaaatctgga ttttcagcga acatgcctga ttttaaaagg ttgactcaag tttttacaaa     1440

atactatgtg ggacacctca aatacatacc tactgactga tgacaaaccc aggagtttgt     1500

gtgtctttta taaaaagttt gccctggatg tcatattggc agttggagga cacagtttct     1560

attgtaaatt tggatttacg actgaagaag gacattttct ctttaaaaga aagttaggtt     1620

ataagaaaca gaggcgtctc acatttttac ttggtgtaat taataaacga agataaatca     1680

tagtgtatgt gtattatgtt gaaaaaaact actctgagta aggatatttc tctcaaatgg     1740

tcatcacttt ttttccttgg aggaagattg tcatgaaggc atcccttcct tcccaaaacg     1800

acaacggcaa caacaacagt ctcctttact tacagctatt aaaagagaca atgtagggaa     1860

agggccaaca ccacttgggc aagcatgagc tgcagcgatg atggtgatgg tagcccagcc     1920

atgctgtgtt cttatcttag agaggacaga gcaggaaact tacaggggta gcagaccttt     1980

ctgatgccaa agaaataagg aggccaaaat catgtttgcc tagctgggag gtaaatctct     2040

tggcagtcag ggtccctgaa cacccagaaa aaataagtga gacttaacgg ttggagagtg     2100

tttgcttgag aaaagtaaca tttcacactc tctatactag acttgcacat atgaatttag     2160

gatgtgcgtg aagattctgc tagcttcaac atatcccaaa gcacttggat atgcctataa     2220

tccaagtgct ttgggaggct gagataggag gattgtttaa ggccaggcat ttgaaatcag     2280

cctgggcaac atagtgagac cctgtctcta caaaaaatta aaaaactagc cacccatggt     2340

ggtgagcgcc tgtagtccta gctactctgg aggctgaggt gggaggatcc cttgagccca     2400

tgaattccag gttagtgtga gctgtgattg tgtcactaca gtgtaaggat gacagaggga     2460

gaccctgtct taaaaaaaaa ttatgctagc ttttaaatca atggttccca aattgtagta     2520

acctgaccaa cagcctcagc aggacctggg aacttgttat aaatgcaaat tgttttgggc     2580

ctcatcctat acccgctgaa tgagaaactc tgagtctgga agcaggctca atagtcaagc     2640

cccctggtga ttctgatgct tagctaaagt tagagaacca ctgttcttag acattgtgca     2700

atgttataca acaacttcct caaagtgcta agtgaaaagg acattggcct ggcgttagtc     2760

agggaaggcg tcctggaggg aggggaattt gaagcagagc tttgaaaaac aaaggcagtg     2820

aggtgaacca gcaagtgcac tggctgaggg gactggagtt ctagcctctg aaccagtttc     2880

ctcctgtgcc aaaggaggat aataattatc tattattgat tatctcctag acttgtggag     2940

ttcaagtgtg taatgcctta aaagatgtgg aggctgttgc tgtgtttggt accacattgc     3000

ccaccctcac gtggcgctct tcagcttagg ttcctctagc agtgtcaagt ttgtgaacca     3060

accccactgg ccttctgcat tctgagggca cgtgtgttaa agtctctact gatgtccttt     3120

tggaaatgcc tctgcatgaa tttatggtag ctctgactca tctttaaaca attttaattt     3180

atttagaaaa taaaggctta tctctccagg aaa                                  3213


<210> 27
<211> 242
<212> PRT
<213> Homo sapiens


<220> 
<223> CD1d transcript variant 2 amino acid sequence

<400> 27
Met Gly Cys Leu Leu Phe Leu Leu Leu Trp Ala Leu Leu Gln Ala Trp 
1               5                   10                  15      
Gly Ser Ala Glu Val Pro Gln Arg Leu Phe Pro Leu Arg Cys Leu Gln 
            20                  25                  30          
Ile Ser Ser Phe Ala Asn Ser Ser Trp Thr Arg Thr Asp Gly Leu Ala 
        35                  40                  45              
Trp Leu Gly Glu Leu Gln Thr His Ser Trp Ser Asn Asp Ser Asp Thr 
    50                  55                  60                  
Val Arg Ser Leu Lys Pro Trp Ser Gln Gly Thr Phe Ser Asp Gln Gln 
65                  70                  75                  80  
Trp Glu Thr Leu Gln His Ile Phe Arg Val Tyr Arg Ser Ser Phe Thr 
                85                  90                  95      
Arg Asp Val Lys Glu Phe Ala Lys Met Leu Arg Leu Ser Tyr Pro Leu 
            100                 105                 110         
Glu Leu Gln Val Ser Ala Gly Cys Glu Val His Pro Gly Asn Ala Ser 
        115                 120                 125             
Asn Asn Phe Phe His Val Ala Phe Gln Gly Lys Asp Ile Leu Ser Phe 
    130                 135                 140                 
Gln Gly Thr Ser Trp Glu Pro Thr Gln Glu Ala Pro Leu Trp Val Asn 
145                 150                 155                 160 
Leu Ala Ile Gln Val Leu Asn Gln Asp Lys Trp Thr Arg Glu Thr Val 
                165                 170                 175     
Gln Trp Leu Leu Asn Gly Thr Cys Pro Gln Phe Val Ser Gly Leu Leu 
            180                 185                 190         
Glu Ser Gly Lys Ser Glu Leu Lys Lys Gln Gly Gly Ser Tyr Thr Ser 
        195                 200                 205             
Met Gly Leu Ile Ala Leu Ala Val Leu Ala Cys Leu Leu Phe Leu Leu 
    210                 215                 220                 
Ile Val Gly Phe Thr Ser Arg Phe Lys Arg Gln Thr Ser Tyr Gln Gly 
225                 230                 235                 240 
Val Leu 
        

<210> 28
<211> 5431
<212> RNA
<213> Homo sapiens


<220> 
<223> CD44 transcript variant 1 mRNA

<400> 28
ctcattgccc agcggacccc agcctctgcc aggttcggtc cgccatcctc gtcccgtcct       60

ccgccggccc ctgccccgcg cccagggatc ctccagctcc tttcgcccgc gccctccgtt      120

cgctccggac accatggaca agttttggtg gcacgcagcc tggggactct gcctcgtgcc      180

gctgagcctg gcgcagatcg atttgaatat aacctgccgc tttgcaggtg tattccacgt      240

ggagaaaaat ggtcgctaca gcatctctcg gacggaggcc gctgacctct gcaaggcttt      300

caatagcacc ttgcccacaa tggcccagat ggagaaagct ctgagcatcg gatttgagac      360

ctgcaggtat gggttcatag aagggcacgt ggtgattccc cggatccacc ccaactccat      420

ctgtgcagca aacaacacag gggtgtacat cctcacatcc aacacctccc agtatgacac      480

atattgcttc aatgcttcag ctccacctga agaagattgt acatcagtca cagacctgcc      540

caatgccttt gatggaccaa ttaccataac tattgttaac cgtgatggca cccgctatgt      600

ccagaaagga gaatacagaa cgaatcctga agacatctac cccagcaacc ctactgatga      660

tgacgtgagc agcggctcct ccagtgaaag gagcagcact tcaggaggtt acatctttta      720

caccttttct actgtacacc ccatcccaga cgaagacagt ccctggatca ccgacagcac      780

agacagaatc cctgctacca ctttgatgag cactagtgct acagcaactg agacagcaac      840

caagaggcaa gaaacctggg attggttttc atggttgttt ctaccatcag agtcaaagaa      900

tcatcttcac acaacaacac aaatggctgg tacgtcttca aataccatct cagcaggctg      960

ggagccaaat gaagaaaatg aagatgaaag agacagacac ctcagttttt ctggatcagg     1020

cattgatgat gatgaagatt ttatctccag caccatttca accacaccac gggcttttga     1080

ccacacaaaa cagaaccagg actggaccca gtggaaccca agccattcaa atccggaagt     1140

gctacttcag acaaccacaa ggatgactga tgtagacaga aatggcacca ctgcttatga     1200

aggaaactgg aacccagaag cacaccctcc cctcattcac catgagcatc atgaggaaga     1260

agagacccca cattctacaa gcacaatcca ggcaactcct agtagtacaa cggaagaaac     1320

agctacccag aaggaacagt ggtttggcaa cagatggcat gagggatatc gccaaacacc     1380

caaagaagac tcccattcga caacagggac agctgcagcc tcagctcata ccagccatcc     1440

aatgcaagga aggacaacac caagcccaga ggacagttcc tggactgatt tcttcaaccc     1500

aatctcacac cccatgggac gaggtcatca agcaggaaga aggatggata tggactccag     1560

tcatagtata acgcttcagc ctactgcaaa tccaaacaca ggtttggtgg aagatttgga     1620

caggacagga cctctttcaa tgacaacgca gcagagtaat tctcagagct tctctacatc     1680

acatgaaggc ttggaagaag ataaagacca tccaacaact tctactctga catcaagcaa     1740

taggaatgat gtcacaggtg gaagaagaga cccaaatcat tctgaaggct caactacttt     1800

actggaaggt tatacctctc attacccaca cacgaaggaa agcaggacct tcatcccagt     1860

gacctcagct aagactgggt cctttggagt tactgcagtt actgttggag attccaactc     1920

taatgtcaat cgttccttat caggagacca agacacattc caccccagtg gggggtccca     1980

taccactcat ggatctgaat cagatggaca ctcacatggg agtcaagaag gtggagcaaa     2040

cacaacctct ggtcctataa ggacacccca aattccagaa tggctgatca tcttggcatc     2100

cctcttggcc ttggctttga ttcttgcagt ttgcattgca gtcaacagtc gaagaaggtg     2160

tgggcagaag aaaaagctag tgatcaacag tggcaatgga gctgtggagg acagaaagcc     2220

aagtggactc aacggagagg ccagcaagtc tcaggaaatg gtgcatttgg tgaacaagga     2280

gtcgtcagaa actccagacc agtttatgac agctgatgag acaaggaacc tgcagaatgt     2340

ggacatgaag attggggtgt aacacctaca ccattatctt ggaaagaaac aaccgttgga     2400

aacataacca ttacagggag ctgggacact taacagatgc aatgtgctac tgattgtttc     2460

attgcgaatc ttttttagca taaaattttc tactcttttt gttttttgtg ttttgttctt     2520

taaagtcagg tccaatttgt aaaaacagca ttgctttctg aaattagggc ccaattaata     2580

atcagcaaga atttgatcgt tccagttccc acttggaggc ctttcatccc tcgggtgtgc     2640

tatggatggc ttctaacaaa aactacacat atgtattcct gatcgccaac ctttccccca     2700

ccagctaagg acatttccca gggttaatag ggcctggtcc ctgggaggaa atttgaatgg     2760

gtccattttg cccttccata gcctaatccc tgggcattgc tttccactga ggttgggggt     2820

tggggtgtac tagttacaca tcttcaacag accccctcta gaaatttttc agatgcttct     2880

gggagacacc caaagggtga agctatttat ctgtagtaaa ctatttatct gtgtttttga     2940

aatattaaac cctggatcag tcctttgatc agtataattt tttaaagtta ctttgtcaga     3000

ggcacaaaag ggtttaaact gattcataat aaatatctgt acttcttcga tcttcacctt     3060

ttgtgctgtg attcttcagt ttctaaacca gcactgtctg ggtccctaca atgtatcagg     3120

aagagctgag aatggtaagg agactcttct aagtcttcat ctcagagacc ctgagttccc     3180

actcagaccc actcagccaa atctcatgga agaccaagga gggcagcact gtttttgttt     3240

tttgtttttt gttttttttt tttgacactg tccaaaggtt ttccatcctg tcctggaatc     3300

agagttggaa gctgaggagc ttcagcctct tttatggttt aatggccacc tgttctctcc     3360

tgtgaaaggc tttgcaaagt cacattaagt ttgcatgacc tgttatccct ggggccctat     3420

ttcatagagg ctggccctat tagtgatttc caaaaacaat atggaagtgc cttttgatgt     3480

cttacaataa gagaagaagc caatggaaat gaaagagatt ggcaaagggg aaggatgatg     3540

ccatgtagat cctgtttgac atttttatgg ctgtatttgt aaacttaaac acaccagtgt     3600

ctgttcttga tgcagttgct atttaggatg agttaagtgc ctggggagtc cctcaaaagg     3660

ttaaagggat tcccatcatt ggaatcttat caccagatag gcaagtttat gaccaaacaa     3720

gagagtactg gctttatcct ctaacctcat attttctccc acttggcaag tcctttgtgg     3780

catttattca tcagtcaggg tgtccgattg gtcctagaac ttccaaaggc tgcttgtcat     3840

agaagccatt gcatctataa agcaacggct cctgttaaat ggtatctcct ttctgaggct     3900

cctactaaaa gtcatttgtt acctaaactt atgtgcttaa caggcaatgc ttctcagacc     3960

acaaagcaga aagaagaaga aaagctcctg actaaatcag ggctgggctt agacagagtt     4020

gatctgtaga atatctttaa aggagagatg tcaactttct gcactattcc cagcctctgc     4080

tcctccctgt ctaccctctc ccctccctct ctccctccac ttcaccccac aatcttgaaa     4140

aacttccttt ctcttctgtg aacatcattg gccagatcca ttttcagtgg tctggatttc     4200

tttttatttt cttttcaact tgaaagaaac tggacattag gccactatgt gttgttactg     4260

ccactagtgt tcaagtgcct cttgttttcc cagagatttc ctgggtctgc cagaggccca     4320

gacaggctca ctcaagctct ttaactgaaa agcaacaagc cactccagga caaggttcaa     4380

aatggttaca acagcctcta cctgtcgccc cagggagaaa ggggtagtga tacaagtctc     4440

atagccagag atggttttcc actccttcta gatattccca aaaagaggct gagacaggag     4500

gttattttca attttatttt ggaattaaat acttttttcc ctttattact gttgtagtcc     4560

ctcacttgga tatacctctg ttttcacgat agaaataagg gaggtctaga gcttctattc     4620

cttggccatt gtcaacggag agctggccaa gtcttcacaa acccttgcaa cattgcctga     4680

agtttatgga ataagatgta ttctcactcc cttgatctca agggcgtaac tctggaagca     4740

cagcttgact acacgtcatt tttaccaatg attttcaggt gacctgggct aagtcattta     4800

aactgggtct ttataaaagt aaaaggccaa catttaatta ttttgcaaag caacctaaga     4860

gctaaagatg taatttttct tgcaattgta aatcttttgt gtctcctgaa gacttccctt     4920

aaaattagct ctgagtgaaa aatcaaaaga gacaaaagac atcttcgaat ccatatttca     4980

agcctggtag aattggcttt tctagcagaa cctttccaaa agttttatat tgagattcat     5040

aacaacacca agaattgatt ttgtagccaa cattcattca atactgttat atcagaggag     5100

taggagagag gaaacatttg acttatctgg aaaagcaaaa tgtacttaag aataagaata     5160

acatggtcca ttcaccttta tgttatagat atgtctttgt gtaaatcatt tgttttgagt     5220

tttcaaagaa tagcccattg ttcattcttg tgctgtacaa tgaccactgt tattgttact     5280

ttgacttttc agagcacacc cttcctctgg tttttgtata tttattgatg gatcaataat     5340

aatgaggaaa gcatgatatg tatattgctg agttgaaagc acttattgga aaatattaaa     5400

aggctaacat taaaagacta aaggaaacag a                                    5431


<210> 29
<211> 742
<212> PRT
<213> Homo sapiens


<220> 
<223> CD44 transcript variant 1 amino acid sequence

<400> 29
Met Asp Lys Phe Trp Trp His Ala Ala Trp Gly Leu Cys Leu Val Pro 
1               5                   10                  15      
Leu Ser Leu Ala Gln Ile Asp Leu Asn Ile Thr Cys Arg Phe Ala Gly 
            20                  25                  30          
Val Phe His Val Glu Lys Asn Gly Arg Tyr Ser Ile Ser Arg Thr Glu 
        35                  40                  45              
Ala Ala Asp Leu Cys Lys Ala Phe Asn Ser Thr Leu Pro Thr Met Ala 
    50                  55                  60                  
Gln Met Glu Lys Ala Leu Ser Ile Gly Phe Glu Thr Cys Arg Tyr Gly 
65                  70                  75                  80  
Phe Ile Glu Gly His Val Val Ile Pro Arg Ile His Pro Asn Ser Ile 
                85                  90                  95      
Cys Ala Ala Asn Asn Thr Gly Val Tyr Ile Leu Thr Ser Asn Thr Ser 
            100                 105                 110         
Gln Tyr Asp Thr Tyr Cys Phe Asn Ala Ser Ala Pro Pro Glu Glu Asp 
        115                 120                 125             
Cys Thr Ser Val Thr Asp Leu Pro Asn Ala Phe Asp Gly Pro Ile Thr 
    130                 135                 140                 
Ile Thr Ile Val Asn Arg Asp Gly Thr Arg Tyr Val Gln Lys Gly Glu 
145                 150                 155                 160 
Tyr Arg Thr Asn Pro Glu Asp Ile Tyr Pro Ser Asn Pro Thr Asp Asp 
                165                 170                 175     
Asp Val Ser Ser Gly Ser Ser Ser Glu Arg Ser Ser Thr Ser Gly Gly 
            180                 185                 190         
Tyr Ile Phe Tyr Thr Phe Ser Thr Val His Pro Ile Pro Asp Glu Asp 
        195                 200                 205             
Ser Pro Trp Ile Thr Asp Ser Thr Asp Arg Ile Pro Ala Thr Thr Leu 
    210                 215                 220                 
Met Ser Thr Ser Ala Thr Ala Thr Glu Thr Ala Thr Lys Arg Gln Glu 
225                 230                 235                 240 
Thr Trp Asp Trp Phe Ser Trp Leu Phe Leu Pro Ser Glu Ser Lys Asn 
                245                 250                 255     
His Leu His Thr Thr Thr Gln Met Ala Gly Thr Ser Ser Asn Thr Ile 
            260                 265                 270         
Ser Ala Gly Trp Glu Pro Asn Glu Glu Asn Glu Asp Glu Arg Asp Arg 
        275                 280                 285             
His Leu Ser Phe Ser Gly Ser Gly Ile Asp Asp Asp Glu Asp Phe Ile 
    290                 295                 300                 
Ser Ser Thr Ile Ser Thr Thr Pro Arg Ala Phe Asp His Thr Lys Gln 
305                 310                 315                 320 
Asn Gln Asp Trp Thr Gln Trp Asn Pro Ser His Ser Asn Pro Glu Val 
                325                 330                 335     
Leu Leu Gln Thr Thr Thr Arg Met Thr Asp Val Asp Arg Asn Gly Thr 
            340                 345                 350         
Thr Ala Tyr Glu Gly Asn Trp Asn Pro Glu Ala His Pro Pro Leu Ile 
        355                 360                 365             
His His Glu His His Glu Glu Glu Glu Thr Pro His Ser Thr Ser Thr 
    370                 375                 380                 
Ile Gln Ala Thr Pro Ser Ser Thr Thr Glu Glu Thr Ala Thr Gln Lys 
385                 390                 395                 400 
Glu Gln Trp Phe Gly Asn Arg Trp His Glu Gly Tyr Arg Gln Thr Pro 
                405                 410                 415     
Lys Glu Asp Ser His Ser Thr Thr Gly Thr Ala Ala Ala Ser Ala His 
            420                 425                 430         
Thr Ser His Pro Met Gln Gly Arg Thr Thr Pro Ser Pro Glu Asp Ser 
        435                 440                 445             
Ser Trp Thr Asp Phe Phe Asn Pro Ile Ser His Pro Met Gly Arg Gly 
    450                 455                 460                 
His Gln Ala Gly Arg Arg Met Asp Met Asp Ser Ser His Ser Ile Thr 
465                 470                 475                 480 
Leu Gln Pro Thr Ala Asn Pro Asn Thr Gly Leu Val Glu Asp Leu Asp 
                485                 490                 495     
Arg Thr Gly Pro Leu Ser Met Thr Thr Gln Gln Ser Asn Ser Gln Ser 
            500                 505                 510         
Phe Ser Thr Ser His Glu Gly Leu Glu Glu Asp Lys Asp His Pro Thr 
        515                 520                 525             
Thr Ser Thr Leu Thr Ser Ser Asn Arg Asn Asp Val Thr Gly Gly Arg 
    530                 535                 540                 
Arg Asp Pro Asn His Ser Glu Gly Ser Thr Thr Leu Leu Glu Gly Tyr 
545                 550                 555                 560 
Thr Ser His Tyr Pro His Thr Lys Glu Ser Arg Thr Phe Ile Pro Val 
                565                 570                 575     
Thr Ser Ala Lys Thr Gly Ser Phe Gly Val Thr Ala Val Thr Val Gly 
            580                 585                 590         
Asp Ser Asn Ser Asn Val Asn Arg Ser Leu Ser Gly Asp Gln Asp Thr 
        595                 600                 605             
Phe His Pro Ser Gly Gly Ser His Thr Thr His Gly Ser Glu Ser Asp 
    610                 615                 620                 
Gly His Ser His Gly Ser Gln Glu Gly Gly Ala Asn Thr Thr Ser Gly 
625                 630                 635                 640 
Pro Ile Arg Thr Pro Gln Ile Pro Glu Trp Leu Ile Ile Leu Ala Ser 
                645                 650                 655     
Leu Leu Ala Leu Ala Leu Ile Leu Ala Val Cys Ile Ala Val Asn Ser 
            660                 665                 670         
Arg Arg Arg Cys Gly Gln Lys Lys Lys Leu Val Ile Asn Ser Gly Asn 
        675                 680                 685             
Gly Ala Val Glu Asp Arg Lys Pro Ser Gly Leu Asn Gly Glu Ala Ser 
    690                 695                 700                 
Lys Ser Gln Glu Met Val His Leu Val Asn Lys Glu Ser Ser Glu Thr 
705                 710                 715                 720 
Pro Asp Gln Phe Met Thr Ala Asp Glu Thr Arg Asn Leu Gln Asn Val 
                725                 730                 735     
Asp Met Lys Ile Gly Val 
            740         

<210> 30
<211> 5302
<212> RNA
<213> Homo sapiens


<220> 
<223> CD44 transcript variant 2 mRNA

<400> 30
ctcattgccc agcggacccc agcctctgcc aggttcggtc cgccatcctc gtcccgtcct       60

ccgccggccc ctgccccgcg cccagggatc ctccagctcc tttcgcccgc gccctccgtt      120

cgctccggac accatggaca agttttggtg gcacgcagcc tggggactct gcctcgtgcc      180

gctgagcctg gcgcagatcg atttgaatat aacctgccgc tttgcaggtg tattccacgt      240

ggagaaaaat ggtcgctaca gcatctctcg gacggaggcc gctgacctct gcaaggcttt      300

caatagcacc ttgcccacaa tggcccagat ggagaaagct ctgagcatcg gatttgagac      360

ctgcaggtat gggttcatag aagggcacgt ggtgattccc cggatccacc ccaactccat      420

ctgtgcagca aacaacacag gggtgtacat cctcacatcc aacacctccc agtatgacac      480

atattgcttc aatgcttcag ctccacctga agaagattgt acatcagtca cagacctgcc      540

caatgccttt gatggaccaa ttaccataac tattgttaac cgtgatggca cccgctatgt      600

ccagaaagga gaatacagaa cgaatcctga agacatctac cccagcaacc ctactgatga      660

tgacgtgagc agcggctcct ccagtgaaag gagcagcact tcaggaggtt acatctttta      720

caccttttct actgtacacc ccatcccaga cgaagacagt ccctggatca ccgacagcac      780

agacagaatc cctgctacca gtacgtcttc aaataccatc tcagcaggct gggagccaaa      840

tgaagaaaat gaagatgaaa gagacagaca cctcagtttt tctggatcag gcattgatga      900

tgatgaagat tttatctcca gcaccatttc aaccacacca cgggcttttg accacacaaa      960

acagaaccag gactggaccc agtggaaccc aagccattca aatccggaag tgctacttca     1020

gacaaccaca aggatgactg atgtagacag aaatggcacc actgcttatg aaggaaactg     1080

gaacccagaa gcacaccctc ccctcattca ccatgagcat catgaggaag aagagacccc     1140

acattctaca agcacaatcc aggcaactcc tagtagtaca acggaagaaa cagctaccca     1200

gaaggaacag tggtttggca acagatggca tgagggatat cgccaaacac ccaaagaaga     1260

ctcccattcg acaacaggga cagctgcagc ctcagctcat accagccatc caatgcaagg     1320

aaggacaaca ccaagcccag aggacagttc ctggactgat ttcttcaacc caatctcaca     1380

ccccatggga cgaggtcatc aagcaggaag aaggatggat atggactcca gtcatagtat     1440

aacgcttcag cctactgcaa atccaaacac aggtttggtg gaagatttgg acaggacagg     1500

acctctttca atgacaacgc agcagagtaa ttctcagagc ttctctacat cacatgaagg     1560

cttggaagaa gataaagacc atccaacaac ttctactctg acatcaagca ataggaatga     1620

tgtcacaggt ggaagaagag acccaaatca ttctgaaggc tcaactactt tactggaagg     1680

ttatacctct cattacccac acacgaagga aagcaggacc ttcatcccag tgacctcagc     1740

taagactggg tcctttggag ttactgcagt tactgttgga gattccaact ctaatgtcaa     1800

tcgttcctta tcaggagacc aagacacatt ccaccccagt ggggggtccc ataccactca     1860

tggatctgaa tcagatggac actcacatgg gagtcaagaa ggtggagcaa acacaacctc     1920

tggtcctata aggacacccc aaattccaga atggctgatc atcttggcat ccctcttggc     1980

cttggctttg attcttgcag tttgcattgc agtcaacagt cgaagaaggt gtgggcagaa     2040

gaaaaagcta gtgatcaaca gtggcaatgg agctgtggag gacagaaagc caagtggact     2100

caacggagag gccagcaagt ctcaggaaat ggtgcatttg gtgaacaagg agtcgtcaga     2160

aactccagac cagtttatga cagctgatga gacaaggaac ctgcagaatg tggacatgaa     2220

gattggggtg taacacctac accattatct tggaaagaaa caaccgttgg aaacataacc     2280

attacaggga gctgggacac ttaacagatg caatgtgcta ctgattgttt cattgcgaat     2340

cttttttagc ataaaatttt ctactctttt tgttttttgt gttttgttct ttaaagtcag     2400

gtccaatttg taaaaacagc attgctttct gaaattaggg cccaattaat aatcagcaag     2460

aatttgatcg ttccagttcc cacttggagg cctttcatcc ctcgggtgtg ctatggatgg     2520

cttctaacaa aaactacaca tatgtattcc tgatcgccaa cctttccccc accagctaag     2580

gacatttccc agggttaata gggcctggtc cctgggagga aatttgaatg ggtccatttt     2640

gcccttccat agcctaatcc ctgggcattg ctttccactg aggttggggg ttggggtgta     2700

ctagttacac atcttcaaca gaccccctct agaaattttt cagatgcttc tgggagacac     2760

ccaaagggtg aagctattta tctgtagtaa actatttatc tgtgtttttg aaatattaaa     2820

ccctggatca gtcctttgat cagtataatt ttttaaagtt actttgtcag aggcacaaaa     2880

gggtttaaac tgattcataa taaatatctg tacttcttcg atcttcacct tttgtgctgt     2940

gattcttcag tttctaaacc agcactgtct gggtccctac aatgtatcag gaagagctga     3000

gaatggtaag gagactcttc taagtcttca tctcagagac cctgagttcc cactcagacc     3060

cactcagcca aatctcatgg aagaccaagg agggcagcac tgtttttgtt ttttgttttt     3120

tgtttttttt ttttgacact gtccaaaggt tttccatcct gtcctggaat cagagttgga     3180

agctgaggag cttcagcctc ttttatggtt taatggccac ctgttctctc ctgtgaaagg     3240

ctttgcaaag tcacattaag tttgcatgac ctgttatccc tggggcccta tttcatagag     3300

gctggcccta ttagtgattt ccaaaaacaa tatggaagtg ccttttgatg tcttacaata     3360

agagaagaag ccaatggaaa tgaaagagat tggcaaaggg gaaggatgat gccatgtaga     3420

tcctgtttga catttttatg gctgtatttg taaacttaaa cacaccagtg tctgttcttg     3480

atgcagttgc tatttaggat gagttaagtg cctggggagt ccctcaaaag gttaaaggga     3540

ttcccatcat tggaatctta tcaccagata ggcaagttta tgaccaaaca agagagtact     3600

ggctttatcc tctaacctca tattttctcc cacttggcaa gtcctttgtg gcatttattc     3660

atcagtcagg gtgtccgatt ggtcctagaa cttccaaagg ctgcttgtca tagaagccat     3720

tgcatctata aagcaacggc tcctgttaaa tggtatctcc tttctgaggc tcctactaaa     3780

agtcatttgt tacctaaact tatgtgctta acaggcaatg cttctcagac cacaaagcag     3840

aaagaagaag aaaagctcct gactaaatca gggctgggct tagacagagt tgatctgtag     3900

aatatcttta aaggagagat gtcaactttc tgcactattc ccagcctctg ctcctccctg     3960

tctaccctct cccctccctc tctccctcca cttcacccca caatcttgaa aaacttcctt     4020

tctcttctgt gaacatcatt ggccagatcc attttcagtg gtctggattt ctttttattt     4080

tcttttcaac ttgaaagaaa ctggacatta ggccactatg tgttgttact gccactagtg     4140

ttcaagtgcc tcttgttttc ccagagattt cctgggtctg ccagaggccc agacaggctc     4200

actcaagctc tttaactgaa aagcaacaag ccactccagg acaaggttca aaatggttac     4260

aacagcctct acctgtcgcc ccagggagaa aggggtagtg atacaagtct catagccaga     4320

gatggttttc cactccttct agatattccc aaaaagaggc tgagacagga ggttattttc     4380

aattttattt tggaattaaa tacttttttc cctttattac tgttgtagtc cctcacttgg     4440

atatacctct gttttcacga tagaaataag ggaggtctag agcttctatt ccttggccat     4500

tgtcaacgga gagctggcca agtcttcaca aacccttgca acattgcctg aagtttatgg     4560

aataagatgt attctcactc ccttgatctc aagggcgtaa ctctggaagc acagcttgac     4620

tacacgtcat ttttaccaat gattttcagg tgacctgggc taagtcattt aaactgggtc     4680

tttataaaag taaaaggcca acatttaatt attttgcaaa gcaacctaag agctaaagat     4740

gtaatttttc ttgcaattgt aaatcttttg tgtctcctga agacttccct taaaattagc     4800

tctgagtgaa aaatcaaaag agacaaaaga catcttcgaa tccatatttc aagcctggta     4860

gaattggctt ttctagcaga acctttccaa aagttttata ttgagattca taacaacacc     4920

aagaattgat tttgtagcca acattcattc aatactgtta tatcagagga gtaggagaga     4980

ggaaacattt gacttatctg gaaaagcaaa atgtacttaa gaataagaat aacatggtcc     5040

attcaccttt atgttataga tatgtctttg tgtaaatcat ttgttttgag ttttcaaaga     5100

atagcccatt gttcattctt gtgctgtaca atgaccactg ttattgttac tttgactttt     5160

cagagcacac ccttcctctg gtttttgtat atttattgat ggatcaataa taatgaggaa     5220

agcatgatat gtatattgct gagttgaaag cacttattgg aaaatattaa aaggctaaca     5280

ttaaaagact aaaggaaaca ga                                              5302


<210> 31
<211> 699
<212> PRT
<213> Homo sapiens


<220> 
<223> CD44 transcript variant 2 amino acid sequence

<400> 31
Met Asp Lys Phe Trp Trp His Ala Ala Trp Gly Leu Cys Leu Val Pro 
1               5                   10                  15      
Leu Ser Leu Ala Gln Ile Asp Leu Asn Ile Thr Cys Arg Phe Ala Gly 
            20                  25                  30          
Val Phe His Val Glu Lys Asn Gly Arg Tyr Ser Ile Ser Arg Thr Glu 
        35                  40                  45              
Ala Ala Asp Leu Cys Lys Ala Phe Asn Ser Thr Leu Pro Thr Met Ala 
    50                  55                  60                  
Gln Met Glu Lys Ala Leu Ser Ile Gly Phe Glu Thr Cys Arg Tyr Gly 
65                  70                  75                  80  
Phe Ile Glu Gly His Val Val Ile Pro Arg Ile His Pro Asn Ser Ile 
                85                  90                  95      
Cys Ala Ala Asn Asn Thr Gly Val Tyr Ile Leu Thr Ser Asn Thr Ser 
            100                 105                 110         
Gln Tyr Asp Thr Tyr Cys Phe Asn Ala Ser Ala Pro Pro Glu Glu Asp 
        115                 120                 125             
Cys Thr Ser Val Thr Asp Leu Pro Asn Ala Phe Asp Gly Pro Ile Thr 
    130                 135                 140                 
Ile Thr Ile Val Asn Arg Asp Gly Thr Arg Tyr Val Gln Lys Gly Glu 
145                 150                 155                 160 
Tyr Arg Thr Asn Pro Glu Asp Ile Tyr Pro Ser Asn Pro Thr Asp Asp 
                165                 170                 175     
Asp Val Ser Ser Gly Ser Ser Ser Glu Arg Ser Ser Thr Ser Gly Gly 
            180                 185                 190         
Tyr Ile Phe Tyr Thr Phe Ser Thr Val His Pro Ile Pro Asp Glu Asp 
        195                 200                 205             
Ser Pro Trp Ile Thr Asp Ser Thr Asp Arg Ile Pro Ala Thr Ser Thr 
    210                 215                 220                 
Ser Ser Asn Thr Ile Ser Ala Gly Trp Glu Pro Asn Glu Glu Asn Glu 
225                 230                 235                 240 
Asp Glu Arg Asp Arg His Leu Ser Phe Ser Gly Ser Gly Ile Asp Asp 
                245                 250                 255     
Asp Glu Asp Phe Ile Ser Ser Thr Ile Ser Thr Thr Pro Arg Ala Phe 
            260                 265                 270         
Asp His Thr Lys Gln Asn Gln Asp Trp Thr Gln Trp Asn Pro Ser His 
        275                 280                 285             
Ser Asn Pro Glu Val Leu Leu Gln Thr Thr Thr Arg Met Thr Asp Val 
    290                 295                 300                 
Asp Arg Asn Gly Thr Thr Ala Tyr Glu Gly Asn Trp Asn Pro Glu Ala 
305                 310                 315                 320 
His Pro Pro Leu Ile His His Glu His His Glu Glu Glu Glu Thr Pro 
                325                 330                 335     
His Ser Thr Ser Thr Ile Gln Ala Thr Pro Ser Ser Thr Thr Glu Glu 
            340                 345                 350         
Thr Ala Thr Gln Lys Glu Gln Trp Phe Gly Asn Arg Trp His Glu Gly 
        355                 360                 365             
Tyr Arg Gln Thr Pro Lys Glu Asp Ser His Ser Thr Thr Gly Thr Ala 
    370                 375                 380                 
Ala Ala Ser Ala His Thr Ser His Pro Met Gln Gly Arg Thr Thr Pro 
385                 390                 395                 400 
Ser Pro Glu Asp Ser Ser Trp Thr Asp Phe Phe Asn Pro Ile Ser His 
                405                 410                 415     
Pro Met Gly Arg Gly His Gln Ala Gly Arg Arg Met Asp Met Asp Ser 
            420                 425                 430         
Ser His Ser Ile Thr Leu Gln Pro Thr Ala Asn Pro Asn Thr Gly Leu 
        435                 440                 445             
Val Glu Asp Leu Asp Arg Thr Gly Pro Leu Ser Met Thr Thr Gln Gln 
    450                 455                 460                 
Ser Asn Ser Gln Ser Phe Ser Thr Ser His Glu Gly Leu Glu Glu Asp 
465                 470                 475                 480 
Lys Asp His Pro Thr Thr Ser Thr Leu Thr Ser Ser Asn Arg Asn Asp 
                485                 490                 495     
Val Thr Gly Gly Arg Arg Asp Pro Asn His Ser Glu Gly Ser Thr Thr 
            500                 505                 510         
Leu Leu Glu Gly Tyr Thr Ser His Tyr Pro His Thr Lys Glu Ser Arg 
        515                 520                 525             
Thr Phe Ile Pro Val Thr Ser Ala Lys Thr Gly Ser Phe Gly Val Thr 
    530                 535                 540                 
Ala Val Thr Val Gly Asp Ser Asn Ser Asn Val Asn Arg Ser Leu Ser 
545                 550                 555                 560 
Gly Asp Gln Asp Thr Phe His Pro Ser Gly Gly Ser His Thr Thr His 
                565                 570                 575     
Gly Ser Glu Ser Asp Gly His Ser His Gly Ser Gln Glu Gly Gly Ala 
            580                 585                 590         
Asn Thr Thr Ser Gly Pro Ile Arg Thr Pro Gln Ile Pro Glu Trp Leu 
        595                 600                 605             
Ile Ile Leu Ala Ser Leu Leu Ala Leu Ala Leu Ile Leu Ala Val Cys 
    610                 615                 620                 
Ile Ala Val Asn Ser Arg Arg Arg Cys Gly Gln Lys Lys Lys Leu Val 
625                 630                 635                 640 
Ile Asn Ser Gly Asn Gly Ala Val Glu Asp Arg Lys Pro Ser Gly Leu 
                645                 650                 655     
Asn Gly Glu Ala Ser Lys Ser Gln Glu Met Val His Leu Val Asn Lys 
            660                 665                 670         
Glu Ser Ser Glu Thr Pro Asp Gln Phe Met Thr Ala Asp Glu Thr Arg 
        675                 680                 685             
Asn Leu Gln Asn Val Asp Met Lys Ile Gly Val 
    690                 695                 

