                         SEQUENCE LISTING

<110>  Ramot at Tel-Aviv University Ltd.
 
<120>  COMPOSITIONS AND METHODS FOR TREATING OSTEOLYSIS

<130>  RAMOT-097 PCT

<150>  62/986,702
<151>  2020-03-08

<150>  63/105,370
<151>  2020-10-26

<160>  26    

<170>  PatentIn version 3.5

<210>  1
<211>  26
<212>  PRT
<213>  Artificial

<220>
<223>  Amino acids


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Z = a permeability enhancing moiety, any amino acid, or absent

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  X= A or G

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  X= Hydrophobic amino acid

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  X= N or S

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  X= T or S

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  X= L or Y

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  X= hydrophobic amino acid

<220>
<221>  MISC_FEATURE
<222>  (25)..(25)
<223>  X= a stretch of 3 amino acid residues selected from NSI and AAV

<400>  1

Glx His Ser Asp Xaa Xaa Phe Thr Asp Xaa Tyr Xaa Arg Xaa Arg Lys 
1               5                   10                  15      


Gln Xaa Ala Val Lys Lys Tyr Leu Xaa Leu 
            20                  25      


<210>  2
<211>  28
<212>  PRT
<213>  Artificail sequence

<400>  2

His Ser Asp Ala Val Phe Thr Asp Asn Tyr Thr Arg Leu Arg Lys Gln 
1               5                   10                  15      


Met Ala Val Lys Lys Tyr Leu Asn Ser Ile Leu Asn 
            20                  25              


<210>  3
<211>  29
<212>  PRT
<213>  Artificial sequence

<220>
<223>  peptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X=Stearyl

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  X=Norleucine

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  X=Amidated asparagine

<400>  3

Xaa His Ser Asp Ala Val Phe Thr Asp Asn Tyr Thr Arg Leu Arg Lys 
1               5                   10                  15      


Gln Xaa Ala Val Lys Lys Tyr Leu Asn Ser Ile Leu Xaa 
            20                  25                  


<210>  4
<211>  27
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Peptide


<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  X=Norleucine (Nle)

<400>  4

His Ser Asp Gly Ile Phe Thr Asp Ser Tyr Ser Arg Tyr Arg Lys Gln 
1               5                   10                  15      


Xaa Ala Val Lys Lys Tyr Leu Ala Ala Val Leu 
            20                  25          


<210>  5
<211>  38
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Peptide


<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  X=Norleucine  (Nle)

<400>  5

His Ser Asp Gly Ile Phe Thr Asp Ser Tyr Ser Arg Tyr Arg Lys Gln 
1               5                   10                  15      


Xaa Ala Val Lys Lys Tyr Leu Ala Ala Val Leu Gly Lys Arg Tyr Lys 
            20                  25                  30          


Gln Arg Val Lys Asn Lys 
        35              


<210>  6
<211>  38
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Peptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  H is N-acetylated

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  X= Norleucine (Nle)

<220>
<221>  MISC_FEATURE
<222>  (38)..(38)
<223>  K is amidated

<400>  6

His Ser Asp Gly Ile Phe Thr Asp Ser Tyr Ser Arg Tyr Arg Lys Gln 
1               5                   10                  15      


Xaa Ala Val Lys Lys Tyr Leu Ala Ala Val Leu Gly Lys Arg Tyr Lys 
            20                  25                  30          


Gln Arg Val Lys Asn Lys 
        35              


<210>  7
<211>  39
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Peptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  H is acetylated

<220>
<221>  MISC_FEATURE
<222>  (39)..(39)
<223>  X=propyl amide

<400>  7

His Ser Asp Gly Ile Phe Thr Asp Ser Tyr Ser Arg Tyr Arg Ala Gln 
1               5                   10                  15      


Met Ala Val Ala Lys Tyr Leu Ala Ala Val Leu Gly Lys Arg Tyr Lys 
            20                  25                  30          


Gln Arg Val Lys Asn Lys Xaa 
        35                  


<210>  8
<211>  38
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Peptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  H is acetylated

<400>  8

His Ser Asp Gly Ile Phe Thr Asp Ser Tyr Ser Arg Tyr Arg Ala Gln 
1               5                   10                  15      


Met Ala Val Ala Lys Tyr Leu Ala Ala Val Leu Gly Lys Arg Tyr Lys 
            20                  25                  30          


Gln Arg Val Lys Asn Lys 
        35              


<210>  9
<211>  38
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Peptide

<400>  9

His Ser Asp Gly Ile Phe Thr Asp Ser Tyr Ser Arg Tyr Arg Lys Gln 
1               5                   10                  15      


Met Ala Val Lys Lys Tyr Leu Ala Ala Val Leu Gly Lys Arg Tyr Lys 
            20                  25                  30          


Gln Arg Val Lys Asn Lys 
        35              


<210>  10
<211>  5
<212>  PRT
<213>  Artificial sequencee

<220>
<223>  Peptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X=Stearyl

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  L is amidated

<400>  10

Xaa Lys Lys Tyr Leu 
1               5   


<210>  11
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Peptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X=Stearyl

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  N is amidated

<400>  11

Xaa Ala Val Lys Lys Tyr Leu Asn Ser Ile Leu Asn 
1               5                   10          


<210>  12
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Peptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X=Stearyl

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  R is amidated

<400>  12

Xaa His Ser Asp Ala Val Phe Thr Asp Asn Tyr Thr Arg Leu Arg 
1               5                   10                  15  


<210>  13
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Peptide

<400>  13

Gly Lys Arg Tyr Lys Gln Arg Val Lys Asn Lys 
1               5                   10      


<210>  14
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Primer

<400>  14
gaaatgccac cttttgacag tg                                                22


<210>  15
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Primer

<400>  15
tggatgctct catcaggaca g                                                 21


<210>  16
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Primer

<400>  16
tagtccttcc taccccaatt tcc                                               23


<210>  17
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Primer

<400>  17
ttggtcctta gccactcctt c                                                 21


<210>  18
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Primer

<400>  18
tcttctcatt cctgcttgtg g                                                 21


<210>  19
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Primer

<400>  19
ggtctgggcc atagaactga                                                   20


<210>  20
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Primer

<400>  20
ccgtaactgc actgaagaag                                                   20


<210>  21
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Primer

<400>  21
ctgttgctgc tcatccatac                                                   20


<210>  22
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Primer

<400>  22
cagcagacca ggaaacataa                                                   20


<210>  23
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Primer

<400>  23
gccacacgca tctatgaa                                                     18


<210>  24
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Primer

<400>  24
acccagaaga ctgtggatgg                                                   20


<210>  25
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Primer

<400>  25
cacattgggg gtaggaacac                                                   20


<210>  26
<211>  28
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Peptide


<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  X-Norleucine

<400>  26

His Ser Asp Ala Val Phe Thr Asp Asn Tyr Thr Arg Leu Arg Lys Gln 
1               5                   10                  15      


Xaa Ala Val Lys Lys Tyr Leu Asn Ser Ile Leu Asn 
            20                  25              


