                         SEQUENCE LISTING

<110>  UCL Business Ltd
 
<120>  GENE THERAPY

<130>  N417890WO

<150>  GB 2003536.6
<151>  2020-03-11

<160>  5     

<170>  PatentIn version 3.5

<210>  1
<211>  307
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  307 bp optimised NPC1 promoter sequence

<400>  1
cgagccagac tccataagtc ccgcgcctgg cccccgggga ttgcaggggc tgaggagaag       60

ggcaacacgg ggaccttgaa gcggggtcgc ggcggcgccc cagcccgggc cagggagtcc      120

cggcagcggc acctcccaga aagggcggag ccgacgacgc cttcttcctt cctgaccggc      180

gcgcgcagcc tgctgccgcg gtcagcgcct gctcctgctc ctccgctcct cctgcgcggg      240

gtgctgaaac agcccgggga agtagagccg cctccgggga gcccaaccag ccgaacgccg      300

ccggcgt                                                                307


<210>  2
<211>  4760
<212>  DNA
<213>  Homo sapiens

<400>  2
cttcctgacc ggcgcgcgca gcctgctgcc gcggtcagcg cctgctcctg ctcctccgct       60

cctcctgcgc ggggtgctga aacagcccgg ggaagtagag ccgcctccgg ggagcccaac      120

cagccgaacg ccgccggcgt cagcagcctt gcgcggccac agcatgaccg ctcgcggcct      180

ggcccttggc ctcctcctgc tgctactgtg tccagcgcag gtgttttcac agtcctgtgt      240

ttggtatgga gagtgtggaa ttgcatatgg ggacaagagg tacaattgcg aatattctgg      300

cccaccaaaa ccattgccaa aggatggata tgacttagtg caggaactct gtccaggatt      360

cttctttggc aatgtcagtc tctgttgtga tgttcggcag cttcagacac taaaagacaa      420

cctgcagctg cctctacagt ttctgtccag atgtccatcc tgtttttata acctactgaa      480

cctgttttgt gagctgacat gtagccctcg acagagtcag tttttgaatg ttacagctac      540

tgaagattat gttgatcctg ttacaaacca gacgaaaaca aatgtgaaag agttacaata      600

ctacgtcgga cagagttttg ccaatgcaat gtacaatgcc tgccgggatg tggaggcccc      660

ctcaagtaat gacaaggccc tgggactcct gtgtgggaag gacgctgacg cctgtaatgc      720

caccaactgg attgaataca tgttcaataa ggacaatgga caggcacctt ttaccatcac      780

tcctgtgttt tcagattttc cagtccatgg gatggagccc atgaacaatg ccaccaaagg      840

ctgtgacgag tctgtggatg aggtcacagc accatgtagc tgccaagact gctctattgt      900

ctgtggcccc aagccccagc ccccacctcc tcctgctccc tggacgatcc ttggcttgga      960

cgccatgtat gtcatcatgt ggatcaccta catggcgttt ttgcttgtgt tttttggagc     1020

attttttgca gtgtggtgct acagaaaacg gtattttgtc tccgagtaca ctcccatcga     1080

tagcaatata gctttttctg ttaatgcaag tgacaaagga gaggcgtcct gctgtgaccc     1140

tgtcagcgca gcatttgagg gctgcttgag gcggctgttc acacgctggg ggtctttctg     1200

cgtccgaaac cctggctgtg tcattttctt ctcgctggtc ttcattactg cgtgttcgtc     1260

aggcctggtg tttgtccggg tcacaaccaa tccagttgac ctctggtcag cccccagcag     1320

ccaggctcgc ctggaaaaag agtactttga ccagcacttt gggcctttct tccggacgga     1380

gcagctcatc atccgggccc ctctcactga caaacacatt taccagccat acccttcggg     1440

agctgatgta ccctttggac ctccgcttga catacagata ctgcaccagg ttcttgactt     1500

acaaatagcc atcgaaaaca ttactgcctc ttatgacaat gagactgtga cacttcaaga     1560

catctgcttg gcccctcttt caccgtataa cacgaactgc accattttga gtgtgttaaa     1620

ttacttccag aacagccatt ccgtgctgga ccacaagaaa ggggacgact tctttgtgta     1680

tgccgattac cacacgcact ttctgtactg cgtacgggct cctgcctctc tgaatgatac     1740

aagtttgctc catgaccctt gtctgggtac gtttggtgga ccagtgttcc cgtggcttgt     1800

gttgggaggc tatgatgatc aaaactacaa taacgccact gcccttgtga ttaccttccc     1860

tgtcaataat tactataatg atacagagaa gctccagagg gcccaggcct gggaaaaaga     1920

gtttattaat tttgtgaaaa actacaagaa tcccaatctg accatttcct tcactgctga     1980

acgaagtatt gaagatgaac taaatcgtga aagtgacagt gatgtcttca ccgttgtaat     2040

tagctatgcc atcatgtttc tatatatttc cctagccttg gggcacatga aaagctgtcg     2100

caggcttctg gtggattcga aggtctcact aggcatcgcg ggcatcttga tcgtgctgag     2160

ctcggtggct tgctccttgg gtgtcttcag ctacattggg ttgcccttga ccctcattgt     2220

gattgaagtc atcccgttcc tggtgctggc tgttggagtg gacaacatct tcattctggt     2280

gcaggcctac cagagagatg aacgtcttca aggggaaacc ctggatcagc agctgggcag     2340

ggtcctagga gaagtggctc ccagtatgtt cctgtcatcc ttttctgaga ctgtagcatt     2400

tttcttagga gcattgtccg tgatgccagc cgtgcacacc ttctctctct ttgcgggatt     2460

ggcagtcttc attgactttc ttctgcagat tacctgtttc gtgagtctct tggggttaga     2520

cattaaacgt caagagaaaa atcggctaga catcttttgc tgtgtcagag gtgctgaaga     2580

tggaacaagc gtccaggcct cagagagctg tttgtttcgc ttcttcaaaa actcctattc     2640

tccacttctg ctaaaggact ggatgagacc aattgtgata gcaatatttg tgggtgttct     2700

gtcattcagc atcgcagtcc tgaacaaagt agatattgga ttggatcagt ctctttcgat     2760

gccagatgac tcctacatgg tggattattt caaatccatc agtcagtacc tgcatgcggg     2820

tccgcctgtg tactttgtcc tggaggaagg gcacgactac acttcttcca aggggcagaa     2880

catggtgtgc ggcggcatgg gctgcaacaa tgattccctg gtgcagcaga tatttaacgc     2940

ggcgcagctg gacaactata cccgaatagg cttcgccccc tcgtcctgga tcgacgatta     3000

tttcgactgg gtgaagccac agtcgtcttg ctgtcgagtg gacaatatca ctgaccagtt     3060

ctgcaatgct tcagtggttg accctgcctg cgttcgctgc aggcctctga ctccggaagg     3120

caaacagagg cctcaggggg gagacttcat gagattcctg cccatgttcc tttcggataa     3180

ccctaacccc aagtgtggca aagggggaca tgctgcctat agttctgcag ttaacatcct     3240

ccttggccat ggcaccaggg tcggagccac gtacttcatg acctaccaca ccgtgctgca     3300

gacctctgct gactttattg acgctctgaa gaaagcccga cttatagcca gtaatgtcac     3360

cgaaaccatg ggcattaacg gcagtgccta ccgagtattt ccttacagtg tgttttatgt     3420

cttctacgaa cagtacctga ccatcattga cgacactatc ttcaacctcg gtgtgtccct     3480

gggcgcgata tttctggtga ccatggtcct cctgggctgt gagctctggt ctgcagtcat     3540

catgtgtgcc accatcgcca tggtcttggt caacatgttt ggagttatgt ggctctgggg     3600

catcagtctg aacgctgtat ccttggtcaa cctggtgatg agctgtggca tctccgtgga     3660

gttctgcagc cacataacca gagcgttcac ggtgagcatg aaaggcagcc gcgtggagcg     3720

cgcggaagag gcacttgccc acatgggcag ctccgtgttc agtggaatca cacttacaaa     3780

atttggaggg attgtggtgt tggcttttgc caaatctcaa attttccaga tattctactt     3840

caggatgtat ttggccatgg tcttactggg agccactcac ggattaatat ttctccctgt     3900

cttactcagt tacatagggc catcagtaaa taaagccaaa agttgtgcca ctgaagagcg     3960

atacaaagga acagagcgcg aacggcttct aaatttctag ccctctcgca gggcatcctg     4020

actgaactgt gtctaagggt cggtcggttt accactggac gggtgctgca tcggcaaggc     4080

caagttgaac accggatggt gccaaccatc ggttgtttgg cagcagcttt gaacgtagcg     4140

cctgtgaact caggaatgca cagttgactt gggaagcagt attactagat ctggaggcaa     4200

ccacaggaca ctaaacttct cccagcctct tcaggaaaga aacctcattc tttggcaagc     4260

aggaggtgac actagatggc tgtgaatgtg atccgctcac tgacactctg taaaggccaa     4320

tcaatgcact gtctgtctct ccttttagga gtaagccatc ccacaagttc tataccatat     4380

ttttagtgac agttgaggtt gtagatacac tttataacat tttatagttt aaagagcttt     4440

attaatgcaa taaattaact ttgtacacat ttttatataa aaaaacagca agtgatttca     4500

gaatgttgta ggcctcatta gagcttggtc tccaaaaatc tgtttgaaaa aagcaacatg     4560

ttcttcacag tgttccccta gaaaggaaga gatttaattg ccagttagat gtggcatgaa     4620

atgagggaca aagaaagcat ctcgtaggtg tgtctactgg gttttaactt atttttcttt     4680

aataaaatac attgttttcc taagttttgg ggttacccta tctgctttga gagacaaata     4740

caaaagctaa atggaagaga                                                 4760


<210>  3
<211>  1278
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Thr Ala Arg Gly Leu Ala Leu Gly Leu Leu Leu Leu Leu Leu Cys 
1               5                   10                  15      


Pro Ala Gln Val Phe Ser Gln Ser Cys Val Trp Tyr Gly Glu Cys Gly 
            20                  25                  30          


Ile Ala Tyr Gly Asp Lys Arg Tyr Asn Cys Glu Tyr Ser Gly Pro Pro 
        35                  40                  45              


Lys Pro Leu Pro Lys Asp Gly Tyr Asp Leu Val Gln Glu Leu Cys Pro 
    50                  55                  60                  


Gly Phe Phe Phe Gly Asn Val Ser Leu Cys Cys Asp Val Arg Gln Leu 
65                  70                  75                  80  


Gln Thr Leu Lys Asp Asn Leu Gln Leu Pro Leu Gln Phe Leu Ser Arg 
                85                  90                  95      


Cys Pro Ser Cys Phe Tyr Asn Leu Leu Asn Leu Phe Cys Glu Leu Thr 
            100                 105                 110         


Cys Ser Pro Arg Gln Ser Gln Phe Leu Asn Val Thr Ala Thr Glu Asp 
        115                 120                 125             


Tyr Val Asp Pro Val Thr Asn Gln Thr Lys Thr Asn Val Lys Glu Leu 
    130                 135                 140                 


Gln Tyr Tyr Val Gly Gln Ser Phe Ala Asn Ala Met Tyr Asn Ala Cys 
145                 150                 155                 160 


Arg Asp Val Glu Ala Pro Ser Ser Asn Asp Lys Ala Leu Gly Leu Leu 
                165                 170                 175     


Cys Gly Lys Asp Ala Asp Ala Cys Asn Ala Thr Asn Trp Ile Glu Tyr 
            180                 185                 190         


Met Phe Asn Lys Asp Asn Gly Gln Ala Pro Phe Thr Ile Thr Pro Val 
        195                 200                 205             


Phe Ser Asp Phe Pro Val His Gly Met Glu Pro Met Asn Asn Ala Thr 
    210                 215                 220                 


Lys Gly Cys Asp Glu Ser Val Asp Glu Val Thr Ala Pro Cys Ser Cys 
225                 230                 235                 240 


Gln Asp Cys Ser Ile Val Cys Gly Pro Lys Pro Gln Pro Pro Pro Pro 
                245                 250                 255     


Pro Ala Pro Trp Thr Ile Leu Gly Leu Asp Ala Met Tyr Val Ile Met 
            260                 265                 270         


Trp Ile Thr Tyr Met Ala Phe Leu Leu Val Phe Phe Gly Ala Phe Phe 
        275                 280                 285             


Ala Val Trp Cys Tyr Arg Lys Arg Tyr Phe Val Ser Glu Tyr Thr Pro 
    290                 295                 300                 


Ile Asp Ser Asn Ile Ala Phe Ser Val Asn Ala Ser Asp Lys Gly Glu 
305                 310                 315                 320 


Ala Ser Cys Cys Asp Pro Val Ser Ala Ala Phe Glu Gly Cys Leu Arg 
                325                 330                 335     


Arg Leu Phe Thr Arg Trp Gly Ser Phe Cys Val Arg Asn Pro Gly Cys 
            340                 345                 350         


Val Ile Phe Phe Ser Leu Val Phe Ile Thr Ala Cys Ser Ser Gly Leu 
        355                 360                 365             


Val Phe Val Arg Val Thr Thr Asn Pro Val Asp Leu Trp Ser Ala Pro 
    370                 375                 380                 


Ser Ser Gln Ala Arg Leu Glu Lys Glu Tyr Phe Asp Gln His Phe Gly 
385                 390                 395                 400 


Pro Phe Phe Arg Thr Glu Gln Leu Ile Ile Arg Ala Pro Leu Thr Asp 
                405                 410                 415     


Lys His Ile Tyr Gln Pro Tyr Pro Ser Gly Ala Asp Val Pro Phe Gly 
            420                 425                 430         


Pro Pro Leu Asp Ile Gln Ile Leu His Gln Val Leu Asp Leu Gln Ile 
        435                 440                 445             


Ala Ile Glu Asn Ile Thr Ala Ser Tyr Asp Asn Glu Thr Val Thr Leu 
    450                 455                 460                 


Gln Asp Ile Cys Leu Ala Pro Leu Ser Pro Tyr Asn Thr Asn Cys Thr 
465                 470                 475                 480 


Ile Leu Ser Val Leu Asn Tyr Phe Gln Asn Ser His Ser Val Leu Asp 
                485                 490                 495     


His Lys Lys Gly Asp Asp Phe Phe Val Tyr Ala Asp Tyr His Thr His 
            500                 505                 510         


Phe Leu Tyr Cys Val Arg Ala Pro Ala Ser Leu Asn Asp Thr Ser Leu 
        515                 520                 525             


Leu His Asp Pro Cys Leu Gly Thr Phe Gly Gly Pro Val Phe Pro Trp 
    530                 535                 540                 


Leu Val Leu Gly Gly Tyr Asp Asp Gln Asn Tyr Asn Asn Ala Thr Ala 
545                 550                 555                 560 


Leu Val Ile Thr Phe Pro Val Asn Asn Tyr Tyr Asn Asp Thr Glu Lys 
                565                 570                 575     


Leu Gln Arg Ala Gln Ala Trp Glu Lys Glu Phe Ile Asn Phe Val Lys 
            580                 585                 590         


Asn Tyr Lys Asn Pro Asn Leu Thr Ile Ser Phe Thr Ala Glu Arg Ser 
        595                 600                 605             


Ile Glu Asp Glu Leu Asn Arg Glu Ser Asp Ser Asp Val Phe Thr Val 
    610                 615                 620                 


Val Ile Ser Tyr Ala Ile Met Phe Leu Tyr Ile Ser Leu Ala Leu Gly 
625                 630                 635                 640 


His Met Lys Ser Cys Arg Arg Leu Leu Val Asp Ser Lys Val Ser Leu 
                645                 650                 655     


Gly Ile Ala Gly Ile Leu Ile Val Leu Ser Ser Val Ala Cys Ser Leu 
            660                 665                 670         


Gly Val Phe Ser Tyr Ile Gly Leu Pro Leu Thr Leu Ile Val Ile Glu 
        675                 680                 685             


Val Ile Pro Phe Leu Val Leu Ala Val Gly Val Asp Asn Ile Phe Ile 
    690                 695                 700                 


Leu Val Gln Ala Tyr Gln Arg Asp Glu Arg Leu Gln Gly Glu Thr Leu 
705                 710                 715                 720 


Asp Gln Gln Leu Gly Arg Val Leu Gly Glu Val Ala Pro Ser Met Phe 
                725                 730                 735     


Leu Ser Ser Phe Ser Glu Thr Val Ala Phe Phe Leu Gly Ala Leu Ser 
            740                 745                 750         


Val Met Pro Ala Val His Thr Phe Ser Leu Phe Ala Gly Leu Ala Val 
        755                 760                 765             


Phe Ile Asp Phe Leu Leu Gln Ile Thr Cys Phe Val Ser Leu Leu Gly 
    770                 775                 780                 


Leu Asp Ile Lys Arg Gln Glu Lys Asn Arg Leu Asp Ile Phe Cys Cys 
785                 790                 795                 800 


Val Arg Gly Ala Glu Asp Gly Thr Ser Val Gln Ala Ser Glu Ser Cys 
                805                 810                 815     


Leu Phe Arg Phe Phe Lys Asn Ser Tyr Ser Pro Leu Leu Leu Lys Asp 
            820                 825                 830         


Trp Met Arg Pro Ile Val Ile Ala Ile Phe Val Gly Val Leu Ser Phe 
        835                 840                 845             


Ser Ile Ala Val Leu Asn Lys Val Asp Ile Gly Leu Asp Gln Ser Leu 
    850                 855                 860                 


Ser Met Pro Asp Asp Ser Tyr Met Val Asp Tyr Phe Lys Ser Ile Ser 
865                 870                 875                 880 


Gln Tyr Leu His Ala Gly Pro Pro Val Tyr Phe Val Leu Glu Glu Gly 
                885                 890                 895     


His Asp Tyr Thr Ser Ser Lys Gly Gln Asn Met Val Cys Gly Gly Met 
            900                 905                 910         


Gly Cys Asn Asn Asp Ser Leu Val Gln Gln Ile Phe Asn Ala Ala Gln 
        915                 920                 925             


Leu Asp Asn Tyr Thr Arg Ile Gly Phe Ala Pro Ser Ser Trp Ile Asp 
    930                 935                 940                 


Asp Tyr Phe Asp Trp Val Lys Pro Gln Ser Ser Cys Cys Arg Val Asp 
945                 950                 955                 960 


Asn Ile Thr Asp Gln Phe Cys Asn Ala Ser Val Val Asp Pro Ala Cys 
                965                 970                 975     


Val Arg Cys Arg Pro Leu Thr Pro Glu Gly Lys Gln Arg Pro Gln Gly 
            980                 985                 990         


Gly Asp Phe Met Arg Phe Leu Pro  Met Phe Leu Ser Asp  Asn Pro Asn 
        995                 1000                 1005             


Pro Lys  Cys Gly Lys Gly Gly  His Ala Ala Tyr Ser  Ser Ala Val 
    1010                 1015                 1020             


Asn Ile  Leu Leu Gly His Gly  Thr Arg Val Gly Ala  Thr Tyr Phe 
    1025                 1030                 1035             


Met Thr  Tyr His Thr Val Leu  Gln Thr Ser Ala Asp  Phe Ile Asp 
    1040                 1045                 1050             


Ala Leu  Lys Lys Ala Arg Leu  Ile Ala Ser Asn Val  Thr Glu Thr 
    1055                 1060                 1065             


Met Gly  Ile Asn Gly Ser Ala  Tyr Arg Val Phe Pro  Tyr Ser Val 
    1070                 1075                 1080             


Phe Tyr  Val Phe Tyr Glu Gln  Tyr Leu Thr Ile Ile  Asp Asp Thr 
    1085                 1090                 1095             


Ile Phe  Asn Leu Gly Val Ser  Leu Gly Ala Ile Phe  Leu Val Thr 
    1100                 1105                 1110             


Met Val  Leu Leu Gly Cys Glu  Leu Trp Ser Ala Val  Ile Met Cys 
    1115                 1120                 1125             


Ala Thr  Ile Ala Met Val Leu  Val Asn Met Phe Gly  Val Met Trp 
    1130                 1135                 1140             


Leu Trp  Gly Ile Ser Leu Asn  Ala Val Ser Leu Val  Asn Leu Val 
    1145                 1150                 1155             


Met Ser  Cys Gly Ile Ser Val  Glu Phe Cys Ser His  Ile Thr Arg 
    1160                 1165                 1170             


Ala Phe  Thr Val Ser Met Lys  Gly Ser Arg Val Glu  Arg Ala Glu 
    1175                 1180                 1185             


Glu Ala  Leu Ala His Met Gly  Ser Ser Val Phe Ser  Gly Ile Thr 
    1190                 1195                 1200             


Leu Thr  Lys Phe Gly Gly Ile  Val Val Leu Ala Phe  Ala Lys Ser 
    1205                 1210                 1215             


Gln Ile  Phe Gln Ile Phe Tyr  Phe Arg Met Tyr Leu  Ala Met Val 
    1220                 1225                 1230             


Leu Leu  Gly Ala Thr His Gly  Leu Ile Phe Leu Pro  Val Leu Leu 
    1235                 1240                 1245             


Ser Tyr  Ile Gly Pro Ser Val  Asn Lys Ala Lys Ser  Cys Ala Thr 
    1250                 1255                 1260             


Glu Glu  Arg Tyr Lys Gly Thr  Glu Arg Glu Arg Leu  Leu Asn Phe 
    1265                 1270                 1275             


<210>  4
<211>  4673
<212>  DNA
<213>  Homo sapiens

<400>  4
tttgctcctg ctcctccgct cctcctgcgc ggggtgctga aacagcccgg ggaagtagag       60

ccgcctccgg ggagcccaac cagccgaacg ccgccggcgt cagcagcctt gcgcggccac      120

agcatgaccg ctcgcggcct ggcccttggc ctcctcctgc tgctactgtg tccagcgcag      180

gtgttttcac agtcctgtgt ttggtatgga gagtgtggaa ttgcatatgg ggacaagagg      240

tacaattgcg aatattctgg cccaccaaaa ccattgccaa aggatggata tgacttagtg      300

caggaactct gtccaggatt cttctttggc aatgtcagtc tctgttgtga tgttcggcag      360

cttcagacac taaaagacaa cctgcagctg cctctacagt ttctgtccag atgtccatcc      420

tgtttttata acctactgaa cctgttttgt gagctgacat gtagccctcg acagagtcag      480

tttttgaatg ttacagctac tgaagattat gttgatcctg ttacaaacca gacgaaaaca      540

aatgtgaaag agttacaata ctacgtcgga cagagttttg ccaatgcaat gtacaatgcc      600

tgccgggatg tggaggcccc ctcaagtaat gacaaggccc tgggactcct gtgtgggaag      660

gacgctgacg cctgtaatgc caccaactgg attgaataca tgttcaataa ggacaatgga      720

caggcacctt ttaccatcac tcctgtgttt tcagattttc cagtccatgg gatggagccc      780

atgaacaatg ccaccaaagg ctgtgacgag tctgtggatg aggtcacagc accatgtagc      840

tgccaagact gctctattgt ctgtggcccc aagccccagc ccccacctcc tcctgctccc      900

tggacgatcc ttggcttgga cgccatgtat gtcatcatgt ggatcaccta catggcgttt      960

ttgcttgtgt tttttggagc attttttgca gtgtggtgct acagaaaacg gtattttgtc     1020

tccgagtaca ctcccatcga tagcaatata gctttttctg ttaatgcaag tgacaaagga     1080

gaggcgtcct gctgtgaccc tgtcagcgca gcatttgagg gctgcttgag gcggctgttc     1140

acacgctggg ggtctttctg cgtccgaaac cctggctgtg tcattttctt ctcgctggtc     1200

ttcattactg cgtgttcgtc aggcctggtg tttgtccggg tcacaaccaa tccagttgac     1260

ctctggtcag cccccagcag ccaggctcgc ctggaaaaag agtactttga ccagcacttt     1320

gggcctttct tccggacgga gcagctcatc atccgggccc ctctcactga caaacacatt     1380

taccagccat acccttcggg agctgatgta ccctttggac ctccgcttga catacagata     1440

ctgcaccagg ttcttgactt acaaatagcc atcgaaaaca ttactgcctc ttatgacaat     1500

gagactgtga cacttcaaga catctgcttg gcccctcttt caccgtataa cacgaactgc     1560

accattttga gtgtgttaaa ttacttccag aacagccatt ccgtgctgga ccacaagaaa     1620

ggggacgact tctttgtgta tgccgattac cacacgcact ttctgtactg cgtacgggct     1680

cctgcctctc tgaatgatac aagtttgctc catgaccctt gtctgggtac gtttggtgga     1740

ccagtgttcc cgtggcttgt gttgggaggc tatgatgatc aaaactacaa taacgccact     1800

gcccttgtga ttaccttccc tgtcaataat tactataatg atacagagaa gctccagagg     1860

gcccaggcct gggaaaaaga gtttattaat tttgtgaaaa actacaagaa tcccaatctg     1920

accatttcct tcactgctga acgaagtatt gaagatgaac taaatcgtga aagtgacagt     1980

gatgtcttca ccgttgtaat tagctatgcc atcatgtttc tatatatttc cctagccttg     2040

gggcacatca aaagctgtcg caggcttctg gtggattcga aggtctcact aggcatcgcg     2100

ggcatcttga tcgtgctgag ctcggtggct tgctccttgg gtgtcttcag ctacattggg     2160

ttgcccttga ccctcattgt gattgaagtc atcccgttcc tggtgctggc tgttggagtg     2220

gacaacatct tcattctggt gcaggcctac cagagagatg aacgtcttca aggggaaacc     2280

ctggatcagc agctgggcag ggtcctagga gaagtggctc ccagtatgtt cctgtcatcc     2340

ttttctgaga ctgtagcatt tttcttagga gcattgtccg tgatgccagc cgtgcacacc     2400

ttctctctct ttgcgggatt ggcagtcttc attgactttc ttctgcagat tacctgtttc     2460

gtgagtctct tggggttaga cattaaacgt caagagaaaa atcggctaga catcttttgc     2520

tgtgtcagag gtgctgaaga tggaacaagc gtccaggcct cagagagctg tttgtttcgc     2580

ttcttcaaaa actcctattc tccacttctg ctaaaggact ggatgagacc aattgtgata     2640

gcaatatttg tgggtgttct gtcattcagc atcgcagtcc tgaacaaagt agatattgga     2700

ttggatcagt ctctttcgat gccagatgac tcctacatgg tggattattt caaatccatc     2760

agtcagtacc tgcatgcggg tccgcctgtg tactttgtcc tggaggaagg gcacgactac     2820

acttcttcca aggggcagaa catggtgtgc ggcggcatgg gctgcaacaa tgattccctg     2880

gtgcagcaga tatttaacgc ggcgcagctg gacaactata cccgaatagg cttcgccccc     2940

tcgtcctgga tcgacgatta tttcgactgg gtgaagccac agtcgtcttg ctgtcgagtg     3000

gacaatatca ctgaccagtt ctgcaatgct tcagtggttg accctgcctg cgttcgctgc     3060

aggcctctga ctccggaagg caaacagagg cctcaggggg gagacttcat gagattcctg     3120

cccatgttcc tttcggataa ccctaacccc aagtgtggca aagggggaca tgctgcctat     3180

agttctgcag ttaacatcct ccttggccat ggcaccaggg tcggagccac gtacttcatg     3240

acctaccaca ccgtgctgca gacctctgct gactttattg acgctctgaa gaaagcccga     3300

cttatagcca gtaatgtcac cgaaaccatg ggcattaacg gcagtgccta ccgagtattt     3360

ccttacagtg tgttttatgt cttctacgaa cagtacctga ccatcattga cgacactatc     3420

ttcaacctcg gtgtgtccct gggcgcgata tttctggtga ccatggtcct cctgggctgt     3480

gagctctggt ctgcagtcat catgtgtgcc accatcgcca tggtcttggt caacatgttt     3540

ggagttatgt ggctctgggg catcagtctg aacgctgtat ccttggtcaa cctggtgatg     3600

agctgtggca tctccgtgga gttctgcagc cacataacca gagcgttcac ggtgagcatg     3660

aaaggcagcc gcgtggagcg cgcggaagag gcacttgccc acatgggcag ctccgtgttc     3720

agtggaatca cacttacaaa atttggaggg attgtggtgt tggcttttgc caaatctcaa     3780

attttccaga tattctactt caggatgtat ttggccatgg tcttactggg agccactcac     3840

ggattaatat ttctccctgt cttactcagt tacatagggc catcagtaaa taaagccaaa     3900

agttgtgcca ctgaagagcg atacaaagga acagagcgcg aacggcttct aaatttctag     3960

ccctctcgca gggcatcctg actgaactgt gtctaagggt cggtcggttt accactggac     4020

gggtgctgca tcggcaaggc caagttgaac accggatggt gccaaccatc ggttgtttgg     4080

cagcagcttt gaacgtagcg cctgtgaact caggaatgca cagttgactt gggaagcagt     4140

attactagat ctggaggcaa ccacaggaca ctaaacttct cccagcctct tcaggaaaga     4200

aacctcattc tttggcaagc aggaggtgac actagatggc tgtgaatgtg atccgctcac     4260

tgacactctg taaaggccaa tcaatgcact gtctgtcctc tcctttttag gagtaagcca     4320

tcccacaagt tctataccat atttttagtg acagttgagg ttgtagatac actttataac     4380

attttatagt ttaaagagct ttattaatgc aataaattaa ctttgtacac atttttatat     4440

aaaaaaacag caagtgattt cagaatgttg taggcctcat tagagcttgg tctccaaaaa     4500

tctgtttgaa aaaagcaaca tgttcttcac agtgttcccc tagaaaggaa gagatttaat     4560

tgccagttag atgtggcatg aaatgaggga caaagaaagc atctcgtagg tgtgtctact     4620

gggttttaac ttatttttct ttaataaaat acattgtttt cctaaaaaaa aaa            4673


<210>  5
<211>  1278
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Thr Ala Arg Gly Leu Ala Leu Gly Leu Leu Leu Leu Leu Leu Cys 
1               5                   10                  15      


Pro Ala Gln Val Phe Ser Gln Ser Cys Val Trp Tyr Gly Glu Cys Gly 
            20                  25                  30          


Ile Ala Tyr Gly Asp Lys Arg Tyr Asn Cys Glu Tyr Ser Gly Pro Pro 
        35                  40                  45              


Lys Pro Leu Pro Lys Asp Gly Tyr Asp Leu Val Gln Glu Leu Cys Pro 
    50                  55                  60                  


Gly Phe Phe Phe Gly Asn Val Ser Leu Cys Cys Asp Val Arg Gln Leu 
65                  70                  75                  80  


Gln Thr Leu Lys Asp Asn Leu Gln Leu Pro Leu Gln Phe Leu Ser Arg 
                85                  90                  95      


Cys Pro Ser Cys Phe Tyr Asn Leu Leu Asn Leu Phe Cys Glu Leu Thr 
            100                 105                 110         


Cys Ser Pro Arg Gln Ser Gln Phe Leu Asn Val Thr Ala Thr Glu Asp 
        115                 120                 125             


Tyr Val Asp Pro Val Thr Asn Gln Thr Lys Thr Asn Val Lys Glu Leu 
    130                 135                 140                 


Gln Tyr Tyr Val Gly Gln Ser Phe Ala Asn Ala Met Tyr Asn Ala Cys 
145                 150                 155                 160 


Arg Asp Val Glu Ala Pro Ser Ser Asn Asp Lys Ala Leu Gly Leu Leu 
                165                 170                 175     


Cys Gly Lys Asp Ala Asp Ala Cys Asn Ala Thr Asn Trp Ile Glu Tyr 
            180                 185                 190         


Met Phe Asn Lys Asp Asn Gly Gln Ala Pro Phe Thr Ile Thr Pro Val 
        195                 200                 205             


Phe Ser Asp Phe Pro Val His Gly Met Glu Pro Met Asn Asn Ala Thr 
    210                 215                 220                 


Lys Gly Cys Asp Glu Ser Val Asp Glu Val Thr Ala Pro Cys Ser Cys 
225                 230                 235                 240 


Gln Asp Cys Ser Ile Val Cys Gly Pro Lys Pro Gln Pro Pro Pro Pro 
                245                 250                 255     


Pro Ala Pro Trp Thr Ile Leu Gly Leu Asp Ala Met Tyr Val Ile Met 
            260                 265                 270         


Trp Ile Thr Tyr Met Ala Phe Leu Leu Val Phe Phe Gly Ala Phe Phe 
        275                 280                 285             


Ala Val Trp Cys Tyr Arg Lys Arg Tyr Phe Val Ser Glu Tyr Thr Pro 
    290                 295                 300                 


Ile Asp Ser Asn Ile Ala Phe Ser Val Asn Ala Ser Asp Lys Gly Glu 
305                 310                 315                 320 


Ala Ser Cys Cys Asp Pro Val Ser Ala Ala Phe Glu Gly Cys Leu Arg 
                325                 330                 335     


Arg Leu Phe Thr Arg Trp Gly Ser Phe Cys Val Arg Asn Pro Gly Cys 
            340                 345                 350         


Val Ile Phe Phe Ser Leu Val Phe Ile Thr Ala Cys Ser Ser Gly Leu 
        355                 360                 365             


Val Phe Val Arg Val Thr Thr Asn Pro Val Asp Leu Trp Ser Ala Pro 
    370                 375                 380                 


Ser Ser Gln Ala Arg Leu Glu Lys Glu Tyr Phe Asp Gln His Phe Gly 
385                 390                 395                 400 


Pro Phe Phe Arg Thr Glu Gln Leu Ile Ile Arg Ala Pro Leu Thr Asp 
                405                 410                 415     


Lys His Ile Tyr Gln Pro Tyr Pro Ser Gly Ala Asp Val Pro Phe Gly 
            420                 425                 430         


Pro Pro Leu Asp Ile Gln Ile Leu His Gln Val Leu Asp Leu Gln Ile 
        435                 440                 445             


Ala Ile Glu Asn Ile Thr Ala Ser Tyr Asp Asn Glu Thr Val Thr Leu 
    450                 455                 460                 


Gln Asp Ile Cys Leu Ala Pro Leu Ser Pro Tyr Asn Thr Asn Cys Thr 
465                 470                 475                 480 


Ile Leu Ser Val Leu Asn Tyr Phe Gln Asn Ser His Ser Val Leu Asp 
                485                 490                 495     


His Lys Lys Gly Asp Asp Phe Phe Val Tyr Ala Asp Tyr His Thr His 
            500                 505                 510         


Phe Leu Tyr Cys Val Arg Ala Pro Ala Ser Leu Asn Asp Thr Ser Leu 
        515                 520                 525             


Leu His Asp Pro Cys Leu Gly Thr Phe Gly Gly Pro Val Phe Pro Trp 
    530                 535                 540                 


Leu Val Leu Gly Gly Tyr Asp Asp Gln Asn Tyr Asn Asn Ala Thr Ala 
545                 550                 555                 560 


Leu Val Ile Thr Phe Pro Val Asn Asn Tyr Tyr Asn Asp Thr Glu Lys 
                565                 570                 575     


Leu Gln Arg Ala Gln Ala Trp Glu Lys Glu Phe Ile Asn Phe Val Lys 
            580                 585                 590         


Asn Tyr Lys Asn Pro Asn Leu Thr Ile Ser Phe Thr Ala Glu Arg Ser 
        595                 600                 605             


Ile Glu Asp Glu Leu Asn Arg Glu Ser Asp Ser Asp Val Phe Thr Val 
    610                 615                 620                 


Val Ile Ser Tyr Ala Ile Met Phe Leu Tyr Ile Ser Leu Ala Leu Gly 
625                 630                 635                 640 


His Ile Lys Ser Cys Arg Arg Leu Leu Val Asp Ser Lys Val Ser Leu 
                645                 650                 655     


Gly Ile Ala Gly Ile Leu Ile Val Leu Ser Ser Val Ala Cys Ser Leu 
            660                 665                 670         


Gly Val Phe Ser Tyr Ile Gly Leu Pro Leu Thr Leu Ile Val Ile Glu 
        675                 680                 685             


Val Ile Pro Phe Leu Val Leu Ala Val Gly Val Asp Asn Ile Phe Ile 
    690                 695                 700                 


Leu Val Gln Ala Tyr Gln Arg Asp Glu Arg Leu Gln Gly Glu Thr Leu 
705                 710                 715                 720 


Asp Gln Gln Leu Gly Arg Val Leu Gly Glu Val Ala Pro Ser Met Phe 
                725                 730                 735     


Leu Ser Ser Phe Ser Glu Thr Val Ala Phe Phe Leu Gly Ala Leu Ser 
            740                 745                 750         


Val Met Pro Ala Val His Thr Phe Ser Leu Phe Ala Gly Leu Ala Val 
        755                 760                 765             


Phe Ile Asp Phe Leu Leu Gln Ile Thr Cys Phe Val Ser Leu Leu Gly 
    770                 775                 780                 


Leu Asp Ile Lys Arg Gln Glu Lys Asn Arg Leu Asp Ile Phe Cys Cys 
785                 790                 795                 800 


Val Arg Gly Ala Glu Asp Gly Thr Ser Val Gln Ala Ser Glu Ser Cys 
                805                 810                 815     


Leu Phe Arg Phe Phe Lys Asn Ser Tyr Ser Pro Leu Leu Leu Lys Asp 
            820                 825                 830         


Trp Met Arg Pro Ile Val Ile Ala Ile Phe Val Gly Val Leu Ser Phe 
        835                 840                 845             


Ser Ile Ala Val Leu Asn Lys Val Asp Ile Gly Leu Asp Gln Ser Leu 
    850                 855                 860                 


Ser Met Pro Asp Asp Ser Tyr Met Val Asp Tyr Phe Lys Ser Ile Ser 
865                 870                 875                 880 


Gln Tyr Leu His Ala Gly Pro Pro Val Tyr Phe Val Leu Glu Glu Gly 
                885                 890                 895     


His Asp Tyr Thr Ser Ser Lys Gly Gln Asn Met Val Cys Gly Gly Met 
            900                 905                 910         


Gly Cys Asn Asn Asp Ser Leu Val Gln Gln Ile Phe Asn Ala Ala Gln 
        915                 920                 925             


Leu Asp Asn Tyr Thr Arg Ile Gly Phe Ala Pro Ser Ser Trp Ile Asp 
    930                 935                 940                 


Asp Tyr Phe Asp Trp Val Lys Pro Gln Ser Ser Cys Cys Arg Val Asp 
945                 950                 955                 960 


Asn Ile Thr Asp Gln Phe Cys Asn Ala Ser Val Val Asp Pro Ala Cys 
                965                 970                 975     


Val Arg Cys Arg Pro Leu Thr Pro Glu Gly Lys Gln Arg Pro Gln Gly 
            980                 985                 990         


Gly Asp Phe Met Arg Phe Leu Pro  Met Phe Leu Ser Asp  Asn Pro Asn 
        995                 1000                 1005             


Pro Lys  Cys Gly Lys Gly Gly  His Ala Ala Tyr Ser  Ser Ala Val 
    1010                 1015                 1020             


Asn Ile  Leu Leu Gly His Gly  Thr Arg Val Gly Ala  Thr Tyr Phe 
    1025                 1030                 1035             


Met Thr  Tyr His Thr Val Leu  Gln Thr Ser Ala Asp  Phe Ile Asp 
    1040                 1045                 1050             


Ala Leu  Lys Lys Ala Arg Leu  Ile Ala Ser Asn Val  Thr Glu Thr 
    1055                 1060                 1065             


Met Gly  Ile Asn Gly Ser Ala  Tyr Arg Val Phe Pro  Tyr Ser Val 
    1070                 1075                 1080             


Phe Tyr  Val Phe Tyr Glu Gln  Tyr Leu Thr Ile Ile  Asp Asp Thr 
    1085                 1090                 1095             


Ile Phe  Asn Leu Gly Val Ser  Leu Gly Ala Ile Phe  Leu Val Thr 
    1100                 1105                 1110             


Met Val  Leu Leu Gly Cys Glu  Leu Trp Ser Ala Val  Ile Met Cys 
    1115                 1120                 1125             


Ala Thr  Ile Ala Met Val Leu  Val Asn Met Phe Gly  Val Met Trp 
    1130                 1135                 1140             


Leu Trp  Gly Ile Ser Leu Asn  Ala Val Ser Leu Val  Asn Leu Val 
    1145                 1150                 1155             


Met Ser  Cys Gly Ile Ser Val  Glu Phe Cys Ser His  Ile Thr Arg 
    1160                 1165                 1170             


Ala Phe  Thr Val Ser Met Lys  Gly Ser Arg Val Glu  Arg Ala Glu 
    1175                 1180                 1185             


Glu Ala  Leu Ala His Met Gly  Ser Ser Val Phe Ser  Gly Ile Thr 
    1190                 1195                 1200             


Leu Thr  Lys Phe Gly Gly Ile  Val Val Leu Ala Phe  Ala Lys Ser 
    1205                 1210                 1215             


Gln Ile  Phe Gln Ile Phe Tyr  Phe Arg Met Tyr Leu  Ala Met Val 
    1220                 1225                 1230             


Leu Leu  Gly Ala Thr His Gly  Leu Ile Phe Leu Pro  Val Leu Leu 
    1235                 1240                 1245             


Ser Tyr  Ile Gly Pro Ser Val  Asn Lys Ala Lys Ser  Cys Ala Thr 
    1250                 1255                 1260             


Glu Glu  Arg Tyr Lys Gly Thr  Glu Arg Glu Arg Leu  Leu Asn Phe 
    1265                 1270                 1275             


