                               SEQUENCE LISTING

<110> THE HENRY M. JACKSON FOUNDATION FOR THE ADVANCEMENT OF 
      MILITARY MEDICINE, INC.
      THE GOVERNMENT OF THE UNITED STATES, AS REPRESENTED BY THE 
      SECRETARY OF THE ARMY
 
<120> VACCINES AGAINST SARS-COV-2 AND OTHER CORONAVIRUSES

<130> 103783-0272

<140> PCT/US2021/021405
<141> 2021-03-08

<150> 63/038,600
<151> 2020-06-12

<150> 62/986,522
<151> 2020-03-06

<160> 346   

<170> PatentIn version 3.5

<210> 1
<211> 175
<212> PRT
<213> Helicobacter pylori

<400> 1
Glu Ser Gln Val Arg Gln Gln Phe Ser Lys Asp Ile Glu Lys Leu Leu 
1               5                   10                  15      


Asn Glu Gln Val Asn Lys Glu Met Gln Ser Ser Asn Leu Tyr Met Ser 
            20                  25                  30          


Met Ser Ser Trp Cys Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe 
        35                  40                  45              


Leu Phe Asp His Ala Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile 
    50                  55                  60                  


Ile Phe Leu Asn Glu Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser 
65                  70                  75                  80  


Ala Pro Glu His Lys Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala 
                85                  90                  95      


Tyr Glu His Glu Gln His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp 
            100                 105                 110         


His Ala Ile Lys Ser Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp 
        115                 120                 125             


Tyr Val Ala Glu Gln His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu 
    130                 135                 140                 


Asp Lys Ile Glu Leu Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala 
145                 150                 155                 160 


Asp Gln Tyr Val Lys Gly Ile Ala Lys Ser Arg Lys Ser Gly Ser 
                165                 170                 175 


<210> 2
<211> 165
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2
Asp Ile Ile Lys Leu Leu Asn Glu Gln Val Asn Lys Glu Met Gln Ser 
1               5                   10                  15      


Ser Asn Leu Tyr Met Ser Met Ser Ser Trp Cys Tyr Thr His Ser Leu 
            20                  25                  30          


Asp Gly Ala Gly Leu Phe Leu Phe Asp His Ala Ala Glu Glu Tyr Glu 
        35                  40                  45              


His Ala Lys Lys Leu Ile Ile Phe Leu Asn Glu Asn Asn Val Pro Val 
    50                  55                  60                  


Gln Leu Thr Ser Ile Ser Ala Pro Glu His Lys Phe Glu Gly Leu Thr 
65                  70                  75                  80  


Gln Ile Phe Gln Lys Ala Tyr Glu His Glu Gln His Ile Ser Glu Ser 
                85                  90                  95      


Ile Asn Asn Ile Val Asp His Ala Ile Lys Ser Lys Asp His Ala Thr 
            100                 105                 110         


Phe Asn Phe Leu Gln Trp Tyr Val Ala Glu Gln His Glu Glu Glu Val 
        115                 120                 125             


Leu Phe Lys Asp Ile Leu Asp Lys Ile Glu Leu Ile Gly Asn Glu Asn 
    130                 135                 140                 


His Gly Leu Tyr Leu Ala Asp Gln Tyr Val Lys Gly Ile Ala Lys Ser 
145                 150                 155                 160 


Arg Lys Ser Gly Ser 
                165 


<210> 3
<211> 167
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3
Ser Lys Asp Ile Ile Lys Leu Leu Asn Glu Gln Val Asn Lys Glu Met 
1               5                   10                  15      


Gln Ser Ser Asn Leu Tyr Met Ser Met Ser Ser Trp Cys Tyr Thr His 
            20                  25                  30          


Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp His Ala Ala Glu Glu 
        35                  40                  45              


Tyr Glu His Ala Lys Lys Leu Ile Ile Phe Leu Asn Glu Asn Asn Val 
    50                  55                  60                  


Pro Val Gln Leu Thr Ser Ile Ser Ala Pro Glu His Lys Phe Glu Gly 
65                  70                  75                  80  


Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu His Glu Gln His Ile Ser 
                85                  90                  95      


Glu Ser Ile Asn Asn Ile Val Asp His Ala Ile Lys Ser Lys Asp His 
            100                 105                 110         


Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala Glu Gln His Glu Glu 
        115                 120                 125             


Glu Val Leu Phe Lys Asp Ile Leu Asp Lys Ile Glu Leu Ile Gly Asn 
    130                 135                 140                 


Glu Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr Val Lys Gly Ile Ala 
145                 150                 155                 160 


Lys Ser Arg Lys Ser Gly Ser 
                165         


<210> 4
<211> 154
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 4
Met Gln Ile Tyr Glu Gly Lys Leu Thr Ala Glu Gly Leu Arg Phe Gly 
1               5                   10                  15      


Ile Val Ala Ser Arg Phe Asn His Ala Leu Val Asp Arg Leu Val Glu 
            20                  25                  30          


Gly Ala Ile Asp Ala Ile Val Arg His Gly Gly Arg Glu Glu Asp Ile 
        35                  40                  45              


Thr Leu Val Arg Val Pro Gly Ser Trp Glu Ile Pro Val Ala Ala Gly 
    50                  55                  60                  


Glu Leu Ala Arg Lys Glu Asp Ile Asp Ala Val Ile Ala Ile Gly Val 
65                  70                  75                  80  


Leu Ile Arg Gly Ala Thr Pro His Phe Asp Tyr Ile Ala Ser Glu Val 
                85                  90                  95      


Ser Lys Gly Leu Ala Asp Leu Ser Leu Glu Leu Arg Lys Pro Ile Thr 
            100                 105                 110         


Phe Gly Val Ile Thr Ala Asp Thr Leu Glu Gln Ala Ile Glu Arg Ala 
        115                 120                 125             


Gly Thr Lys His Gly Asn Lys Gly Trp Glu Ala Ala Leu Ser Ala Ile 
    130                 135                 140                 


Glu Met Ala Asn Leu Phe Lys Ser Leu Arg 
145                 150                 


<210> 5
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 5
Gly Ser Gly Gly 
1               


<210> 6
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 6
Gly Ser Gly Gly Ser Gly 
1               5       


<210> 7
<211> 42
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 7
Gly Ser Gly Gly Glu Met Lys Gln Ile Glu Asp Lys Ile Glu Glu Ile 
1               5                   10                  15      


Leu Ser Lys Ile Tyr His Ile Glu Asn Glu Ile Ala Arg Ile Lys Lys 
            20                  25                  30          


Leu Ile Gly Arg Gly Ser Gly Gly Ser Gly 
        35                  40          


<210> 8
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 8
Leu Asp Ser Ile Lys Glu Glu Leu Asp Lys Ile His Lys Asn Gly Ser 
1               5                   10                  15      


Gly Gly Ser Gly 
            20  


<210> 9
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 9
Ile Asp Ser Ile Lys Glu Glu Ile Asp Lys Ile His Lys Asn Gly Ser 
1               5                   10                  15      


Gly Gly Ser Gly 
            20  


<210> 10
<211> 37
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 10
Met Lys Gln Ile Glu Asp Lys Ile Glu Glu Ile Leu Ser Lys Ile Tyr 
1               5                   10                  15      


His Ile Glu Asn Glu Ile Ala Arg Ile Lys Lys Leu Ile Gly Arg Gly 
            20                  25                  30          


Ser Gly Gly Ser Gly 
        35          


<210> 11
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 11
Gly Ser Gly Gly Gly Gly 
1               5       


<210> 12
<211> 3
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 12
Gly Ser Gly 
1           


<210> 13
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 13
Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Gly 
1               5                   10                  


<210> 14
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 14
Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly 
1               5                   10  


<210> 15
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 15
Gly Gly Gly Gly 
1               


<210> 16
<211> 3
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 16
Gly Gly Gly 
1           


<210> 17
<211> 3
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 17
Ser Gly Gly 
1           


<210> 18
<211> 1273
<212> PRT
<213> Severe acute respiratory syndrome coronavirus 2

<400> 18
Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
                245                 250                 255     


Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270         


Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285             


Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                 


Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
305                 310                 315                 320 


Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 
                325                 330                 335     


Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 
            340                 345                 350         


Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
        355                 360                 365             


Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
    370                 375                 380                 


Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
385                 390                 395                 400 


Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
                405                 410                 415     


Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
            420                 425                 430         


Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
        435                 440                 445             


Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
    450                 455                 460                 


Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
465                 470                 475                 480 


Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
                485                 490                 495     


Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
            500                 505                 510         


Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
        515                 520                 525             


Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
    530                 535                 540                 


Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
545                 550                 555                 560 


Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 
                565                 570                 575     


Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 
            580                 585                 590         


Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 
        595                 600                 605             


Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile 
    610                 615                 620                 


His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 
625                 630                 635                 640 


Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val 
                645                 650                 655     


Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 
            660                 665                 670         


Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala 
        675                 680                 685             


Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser 
    690                 695                 700                 


Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile 
705                 710                 715                 720 


Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 
                725                 730                 735     


Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu 
            740                 745                 750         


Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr 
        755                 760                 765             


Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln 
    770                 775                 780                 


Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe 
785                 790                 795                 800 


Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser 
                805                 810                 815     


Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly 
            820                 825                 830         


Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp 
        835                 840                 845             


Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu 
    850                 855                 860                 


Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly 
865                 870                 875                 880 


Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile 
                885                 890                 895     


Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr 
            900                 905                 910         


Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn 
        915                 920                 925             


Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala 
    930                 935                 940                 


Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn 
945                 950                 955                 960 


Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val 
                965                 970                 975     


Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln 
            980                 985                 990         


Ile Asp Arg Leu Ile Thr Gly Arg  Leu Gln Ser Leu Gln  Thr Tyr Val 
        995                 1000                 1005             


Thr Gln  Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
    1010                 1015                 1020             


Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1025                 1030                 1035             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1040                 1045                 1050             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1055                 1060                 1065             


Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1070                 1075                 1080             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1085                 1090                 1095             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1100                 1105                 1110             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1115                 1120                 1125             


Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro 
    1130                 1135                 1140             


Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Tyr  Phe Lys Asn 
    1145                 1150                 1155             


His Thr  Ser Pro Asp Val Asp  Leu Gly Asp Ile Ser  Gly Ile Asn 
    1160                 1165                 1170             


Ala Ser  Val Val Asn Ile Gln  Lys Glu Ile Asp Arg  Leu Asn Glu 
    1175                 1180                 1185             


Val Ala  Lys Asn Leu Asn Glu  Ser Leu Ile Asp Leu  Gln Glu Leu 
    1190                 1195                 1200             


Gly Lys  Tyr Glu Gln Tyr Ile  Lys Trp Pro Trp Tyr  Ile Trp Leu 
    1205                 1210                 1215             


Gly Phe  Ile Ala Gly Leu Ile  Ala Ile Val Met Val  Thr Ile Met 
    1220                 1225                 1230             


Leu Cys  Cys Met Thr Ser Cys  Cys Ser Cys Leu Lys  Gly Cys Cys 
    1235                 1240                 1245             


Ser Cys  Gly Ser Cys Cys Lys  Phe Asp Glu Asp Asp  Ser Glu Pro 
    1250                 1255                 1260             


Val Leu  Lys Gly Val Lys Leu  His Tyr Thr 
    1265                 1270             


<210> 19
<211> 197
<212> PRT
<213> Severe acute respiratory syndrome coronavirus 2

<400> 19
Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg 
1               5                   10                  15      


Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val 
            20                  25                  30          


Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys 
        35                  40                  45              


Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn 
    50                  55                  60                  


Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile 
65                  70                  75                  80  


Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro 
                85                  90                  95      


Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp 
            100                 105                 110         


Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys 
        115                 120                 125             


Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln 
    130                 135                 140                 


Ala Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe 
145                 150                 155                 160 


Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln 
                165                 170                 175     


Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala 
            180                 185                 190         


Thr Val Cys Gly Pro 
        195         


<210> 20
<211> 290
<212> PRT
<213> Severe acute respiratory syndrome coronavirus 2

<400> 20
Gln Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr 
1               5                   10                  15      


Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser 
            20                  25                  30          


Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn 
        35                  40                  45              


Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys 
    50                  55                  60                  


Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala 
65                  70                  75                  80  


Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr 
                85                  90                  95      


Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn 
            100                 105                 110         


Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu 
        115                 120                 125             


Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe 
    130                 135                 140                 


Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln 
145                 150                 155                 160 


Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu 
                165                 170                 175     


Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser 
            180                 185                 190         


Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser 
        195                 200                 205             


Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg 
    210                 215                 220                 


Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp 
225                 230                 235                 240 


Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr 
                245                 250                 255     


Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile 
            260                 265                 270         


Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys 
        275                 280                 285             


Thr Leu 
    290 


<210> 21
<211> 663
<212> PRT
<213> Severe acute respiratory syndrome coronavirus 2

<400> 21
Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser 
1               5                   10                  15      


Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val 
            20                  25                  30          


Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr 
        35                  40                  45              


Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe 
    50                  55                  60                  


Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr 
65                  70                  75                  80  


Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp 
                85                  90                  95      


Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val 
            100                 105                 110         


Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val 
        115                 120                 125             


Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val 
    130                 135                 140                 


Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe 
145                 150                 155                 160 


Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu 
                165                 170                 175     


Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His 
            180                 185                 190         


Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu 
        195                 200                 205             


Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln 
    210                 215                 220                 


Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser 
225                 230                 235                 240 


Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln 
                245                 250                 255     


Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp 
            260                 265                 270         


Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu 
        275                 280                 285             


Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg 
    290                 295                 300                 


Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu 
305                 310                 315                 320 


Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr 
                325                 330                 335     


Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val 
            340                 345                 350         


Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser 
        355                 360                 365             


Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser 
    370                 375                 380                 


Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr 
385                 390                 395                 400 


Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly 
                405                 410                 415     


Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly 
            420                 425                 430         


Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro 
        435                 440                 445             


Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro 
    450                 455                 460                 


Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr 
465                 470                 475                 480 


Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val 
                485                 490                 495     


Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro 
            500                 505                 510         


Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe 
        515                 520                 525             


Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe 
    530                 535                 540                 


Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala 
545                 550                 555                 560 


Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser 
                565                 570                 575     


Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln 
            580                 585                 590         


Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala 
        595                 600                 605             


Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly 
    610                 615                 620                 


Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His 
625                 630                 635                 640 


Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys 
                645                 650                 655     


Ala Ser Tyr Gln Thr Gln Thr 
            660             


<210> 22
<211> 672
<212> PRT
<213> Severe acute respiratory syndrome coronavirus 2

<400> 22
Gln Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr 
1               5                   10                  15      


Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser 
            20                  25                  30          


Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn 
        35                  40                  45              


Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys 
    50                  55                  60                  


Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala 
65                  70                  75                  80  


Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr 
                85                  90                  95      


Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn 
            100                 105                 110         


Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu 
        115                 120                 125             


Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe 
    130                 135                 140                 


Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln 
145                 150                 155                 160 


Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu 
                165                 170                 175     


Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser 
            180                 185                 190         


Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser 
        195                 200                 205             


Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg 
    210                 215                 220                 


Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp 
225                 230                 235                 240 


Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr 
                245                 250                 255     


Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile 
            260                 265                 270         


Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys 
        275                 280                 285             


Thr Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn 
    290                 295                 300                 


Phe Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr 
305                 310                 315                 320 


Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser 
                325                 330                 335     


Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr 
            340                 345                 350         


Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly 
        355                 360                 365             


Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala 
    370                 375                 380                 


Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly 
385                 390                 395                 400 


Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe 
                405                 410                 415     


Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val 
            420                 425                 430         


Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu 
        435                 440                 445             


Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser 
    450                 455                 460                 


Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln 
465                 470                 475                 480 


Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg 
                485                 490                 495     


Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys 
            500                 505                 510         


Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe 
        515                 520                 525             


Asn Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys 
    530                 535                 540                 


Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr 
545                 550                 555                 560 


Asp Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro 
                565                 570                 575     


Cys Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser 
            580                 585                 590         


Asn Gln Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro 
        595                 600                 605             


Val Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser 
    610                 615                 620                 


Thr Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala 
625                 630                 635                 640 


Glu His Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly 
                645                 650                 655     


Ile Cys Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg 
            660                 665                 670         


<210> 23
<211> 378
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 23
Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg 
1               5                   10                  15      


Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val 
            20                  25                  30          


Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys 
        35                  40                  45              


Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn 
    50                  55                  60                  


Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile 
65                  70                  75                  80  


Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro 
                85                  90                  95      


Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp 
            100                 105                 110         


Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys 
        115                 120                 125             


Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln 
    130                 135                 140                 


Ala Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe 
145                 150                 155                 160 


Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln 
                165                 170                 175     


Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala 
            180                 185                 190         


Thr Val Cys Gly Pro Gly Ser Gly Gly Gly Gly Glu Ser Gln Val Arg 
        195                 200                 205             


Gln Gln Phe Ser Lys Asp Ile Glu Lys Leu Leu Asn Glu Gln Val Asn 
    210                 215                 220                 


Lys Glu Met Gln Ser Ser Asn Leu Tyr Met Ser Met Ser Ser Trp Cys 
225                 230                 235                 240 


Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp His Ala 
                245                 250                 255     


Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe Leu Asn Glu 
            260                 265                 270         


Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro Glu His Lys 
        275                 280                 285             


Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu His Glu Gln 
    290                 295                 300                 


His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala Ile Lys Ser 
305                 310                 315                 320 


Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala Glu Gln 
                325                 330                 335     


His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys Ile Glu Leu 
            340                 345                 350         


Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr Val Lys 
        355                 360                 365             


Gly Ile Ala Lys Ser Arg Lys Ser Gly Ser 
    370                 375             


<210> 24
<211> 844
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 24
Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser 
1               5                   10                  15      


Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val 
            20                  25                  30          


Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr 
        35                  40                  45              


Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe 
    50                  55                  60                  


Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr 
65                  70                  75                  80  


Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp 
                85                  90                  95      


Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val 
            100                 105                 110         


Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val 
        115                 120                 125             


Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val 
    130                 135                 140                 


Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe 
145                 150                 155                 160 


Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu 
                165                 170                 175     


Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His 
            180                 185                 190         


Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu 
        195                 200                 205             


Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln 
    210                 215                 220                 


Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser 
225                 230                 235                 240 


Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln 
                245                 250                 255     


Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp 
            260                 265                 270         


Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu 
        275                 280                 285             


Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg 
    290                 295                 300                 


Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu 
305                 310                 315                 320 


Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr 
                325                 330                 335     


Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val 
            340                 345                 350         


Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser 
        355                 360                 365             


Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser 
    370                 375                 380                 


Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr 
385                 390                 395                 400 


Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly 
                405                 410                 415     


Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly 
            420                 425                 430         


Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro 
        435                 440                 445             


Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro 
    450                 455                 460                 


Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr 
465                 470                 475                 480 


Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val 
                485                 490                 495     


Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro 
            500                 505                 510         


Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe 
        515                 520                 525             


Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe 
    530                 535                 540                 


Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala 
545                 550                 555                 560 


Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser 
                565                 570                 575     


Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln 
            580                 585                 590         


Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala 
        595                 600                 605             


Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly 
    610                 615                 620                 


Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His 
625                 630                 635                 640 


Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys 
                645                 650                 655     


Ala Ser Tyr Gln Thr Gln Thr Gly Ser Gly Gly Gly Gly Glu Ser Gln 
            660                 665                 670         


Val Arg Gln Gln Phe Ser Lys Asp Ile Glu Lys Leu Leu Asn Glu Gln 
        675                 680                 685             


Val Asn Lys Glu Met Gln Ser Ser Asn Leu Tyr Met Ser Met Ser Ser 
    690                 695                 700                 


Trp Cys Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp 
705                 710                 715                 720 


His Ala Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe Leu 
                725                 730                 735     


Asn Glu Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro Glu 
            740                 745                 750         


His Lys Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu His 
        755                 760                 765             


Glu Gln His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala Ile 
    770                 775                 780                 


Lys Ser Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala 
785                 790                 795                 800 


Glu Gln His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys Ile 
                805                 810                 815     


Glu Leu Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr 
            820                 825                 830         


Val Lys Gly Ile Ala Lys Ser Arg Lys Ser Gly Ser 
        835                 840                 


<210> 25
<211> 396
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 25
His His His His His His His His Gly Pro Leu Glu Val Leu Phe Gln 
1               5                   10                  15      


Gly Pro Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala 
            20                  25                  30          


Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn 
        35                  40                  45              


Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr 
    50                  55                  60                  


Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe 
65                  70                  75                  80  


Thr Asn Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg 
                85                  90                  95      


Gln Ile Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys 
            100                 105                 110         


Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn 
        115                 120                 125             


Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe 
    130                 135                 140                 


Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile 
145                 150                 155                 160 


Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys 
                165                 170                 175     


Tyr Phe Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly 
            180                 185                 190         


Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala 
        195                 200                 205             


Pro Ala Thr Val Cys Gly Pro Gly Ser Gly Gly Gly Gly Glu Ser Gln 
    210                 215                 220                 


Val Arg Gln Gln Phe Ser Lys Asp Ile Glu Lys Leu Leu Asn Glu Gln 
225                 230                 235                 240 


Val Asn Lys Glu Met Gln Ser Ser Asn Leu Tyr Met Ser Met Ser Ser 
                245                 250                 255     


Trp Cys Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp 
            260                 265                 270         


His Ala Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe Leu 
        275                 280                 285             


Asn Glu Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro Glu 
    290                 295                 300                 


His Lys Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu His 
305                 310                 315                 320 


Glu Gln His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala Ile 
                325                 330                 335     


Lys Ser Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala 
            340                 345                 350         


Glu Gln His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys Ile 
        355                 360                 365             


Glu Leu Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr 
    370                 375                 380                 


Val Lys Gly Ile Ala Lys Ser Arg Lys Ser Gly Ser 
385                 390                 395     


<210> 26
<211> 862
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 26
His His His His His His His His Gly Pro Leu Glu Val Leu Phe Gln 
1               5                   10                  15      


Gly Pro Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr 
            20                  25                  30          


Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser 
        35                  40                  45              


Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn 
    50                  55                  60                  


Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys 
65                  70                  75                  80  


Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala 
                85                  90                  95      


Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr 
            100                 105                 110         


Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn 
        115                 120                 125             


Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu 
    130                 135                 140                 


Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe 
145                 150                 155                 160 


Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln 
                165                 170                 175     


Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu 
            180                 185                 190         


Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser 
        195                 200                 205             


Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser 
    210                 215                 220                 


Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg 
225                 230                 235                 240 


Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp 
                245                 250                 255     


Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr 
            260                 265                 270         


Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile 
        275                 280                 285             


Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys 
    290                 295                 300                 


Thr Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn 
305                 310                 315                 320 


Phe Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr 
                325                 330                 335     


Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser 
            340                 345                 350         


Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr 
        355                 360                 365             


Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly 
    370                 375                 380                 


Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala 
385                 390                 395                 400 


Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly 
                405                 410                 415     


Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe 
            420                 425                 430         


Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val 
        435                 440                 445             


Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu 
    450                 455                 460                 


Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser 
465                 470                 475                 480 


Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln 
                485                 490                 495     


Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg 
            500                 505                 510         


Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys 
        515                 520                 525             


Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe 
    530                 535                 540                 


Asn Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys 
545                 550                 555                 560 


Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr 
                565                 570                 575     


Asp Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro 
            580                 585                 590         


Cys Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser 
        595                 600                 605             


Asn Gln Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro 
    610                 615                 620                 


Val Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser 
625                 630                 635                 640 


Thr Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala 
                645                 650                 655     


Glu His Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly 
            660                 665                 670         


Ile Cys Ala Ser Tyr Gln Thr Gln Thr Gly Ser Gly Gly Gly Gly Glu 
        675                 680                 685             


Ser Gln Val Arg Gln Gln Phe Ser Lys Asp Ile Glu Lys Leu Leu Asn 
    690                 695                 700                 


Glu Gln Val Asn Lys Glu Met Gln Ser Ser Asn Leu Tyr Met Ser Met 
705                 710                 715                 720 


Ser Ser Trp Cys Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu 
                725                 730                 735     


Phe Asp His Ala Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile 
            740                 745                 750         


Phe Leu Asn Glu Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala 
        755                 760                 765             


Pro Glu His Lys Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr 
    770                 775                 780                 


Glu His Glu Gln His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp His 
785                 790                 795                 800 


Ala Ile Lys Ser Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp Tyr 
                805                 810                 815     


Val Ala Glu Gln His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu Asp 
            820                 825                 830         


Lys Ile Glu Leu Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala Asp 
        835                 840                 845             


Gln Tyr Val Lys Gly Ile Ala Lys Ser Arg Lys Ser Gly Ser 
    850                 855                 860         


<210> 27
<211> 375
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 27
Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser 
1               5                   10                  15      


Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr 
            20                  25                  30          


Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly 
        35                  40                  45              


Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala 
    50                  55                  60                  


Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly 
65                  70                  75                  80  


Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe 
                85                  90                  95      


Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val 
            100                 105                 110         


Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu 
        115                 120                 125             


Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser 
    130                 135                 140                 


Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln 
145                 150                 155                 160 


Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg 
                165                 170                 175     


Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys 
            180                 185                 190         


Gly Pro Gly Ser Gly Gly Gly Gly Glu Ser Gln Val Arg Gln Gln Phe 
        195                 200                 205             


Ser Lys Asp Ile Glu Lys Leu Leu Asn Glu Gln Val Asn Lys Glu Met 
    210                 215                 220                 


Gln Ser Ser Asn Leu Tyr Met Ser Met Ser Ser Trp Cys Tyr Thr His 
225                 230                 235                 240 


Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp His Ala Ala Glu Glu 
                245                 250                 255     


Tyr Glu His Ala Lys Lys Leu Ile Ile Phe Leu Asn Glu Asn Asn Val 
            260                 265                 270         


Pro Val Gln Leu Thr Ser Ile Ser Ala Pro Glu His Lys Phe Glu Gly 
        275                 280                 285             


Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu His Glu Gln His Ile Ser 
    290                 295                 300                 


Glu Ser Ile Asn Asn Ile Val Asp His Ala Ile Lys Ser Lys Asp His 
305                 310                 315                 320 


Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala Glu Gln His Glu Glu 
                325                 330                 335     


Glu Val Leu Phe Lys Asp Ile Leu Asp Lys Ile Glu Leu Ile Gly Asn 
            340                 345                 350         


Glu Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr Val Lys Gly Ile Ala 
        355                 360                 365             


Lys Ser Arg Lys Ser Gly Ser 
    370                 375 


<210> 28
<211> 393
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 28
His His His His His His His His Gly Pro Leu Glu Val Leu Phe Gln 
1               5                   10                  15      


Gly Pro Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala 
            20                  25                  30          


Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn 
        35                  40                  45              


Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr 
    50                  55                  60                  


Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe 
65                  70                  75                  80  


Thr Asn Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg 
                85                  90                  95      


Gln Ile Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys 
            100                 105                 110         


Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn 
        115                 120                 125             


Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe 
    130                 135                 140                 


Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile 
145                 150                 155                 160 


Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys 
                165                 170                 175     


Tyr Phe Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly 
            180                 185                 190         


Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala 
        195                 200                 205             


Pro Ala Thr Val Cys Gly Pro Gly Ser Gly Glu Ser Gln Val Arg Gln 
    210                 215                 220                 


Gln Phe Ser Lys Asp Ile Glu Lys Leu Leu Asn Glu Gln Val Asn Lys 
225                 230                 235                 240 


Glu Met Gln Ser Ser Asn Leu Tyr Met Ser Met Ser Ser Trp Cys Tyr 
                245                 250                 255     


Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp His Ala Ala 
            260                 265                 270         


Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe Leu Asn Glu Asn 
        275                 280                 285             


Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro Glu His Lys Phe 
    290                 295                 300                 


Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu His Glu Gln His 
305                 310                 315                 320 


Ile Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala Ile Lys Ser Lys 
                325                 330                 335     


Asp His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala Glu Gln His 
            340                 345                 350         


Glu Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys Ile Glu Leu Ile 
        355                 360                 365             


Gly Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr Val Lys Gly 
    370                 375                 380                 


Ile Ala Lys Ser Arg Lys Ser Gly Ser 
385                 390             


<210> 29
<211> 393
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 29
His His His His His His His His Gly Pro Leu Glu Val Leu Phe Gln 
1               5                   10                  15      


Gly Pro Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe 
            20                  25                  30          


Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala 
        35                  40                  45              


Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys 
    50                  55                  60                  


Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val 
65                  70                  75                  80  


Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala 
                85                  90                  95      


Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp 
            100                 105                 110         


Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser 
        115                 120                 125             


Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser 
    130                 135                 140                 


Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala 
145                 150                 155                 160 


Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro 
                165                 170                 175     


Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro 
            180                 185                 190         


Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr 
        195                 200                 205             


Val Cys Gly Pro Gly Ser Gly Gly Gly Gly Glu Ser Gln Val Arg Gln 
    210                 215                 220                 


Gln Phe Ser Lys Asp Ile Glu Lys Leu Leu Asn Glu Gln Val Asn Lys 
225                 230                 235                 240 


Glu Met Gln Ser Ser Asn Leu Tyr Met Ser Met Ser Ser Trp Cys Tyr 
                245                 250                 255     


Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp His Ala Ala 
            260                 265                 270         


Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe Leu Asn Glu Asn 
        275                 280                 285             


Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro Glu His Lys Phe 
    290                 295                 300                 


Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu His Glu Gln His 
305                 310                 315                 320 


Ile Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala Ile Lys Ser Lys 
                325                 330                 335     


Asp His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala Glu Gln His 
            340                 345                 350         


Glu Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys Ile Glu Leu Ile 
        355                 360                 365             


Gly Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr Val Lys Gly 
    370                 375                 380                 


Ile Ala Lys Ser Arg Lys Ser Gly Ser 
385                 390             


<210> 30
<211> 375
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 30
His His His His His His His His Gly Pro Leu Glu Val Leu Phe Gln 
1               5                   10                  15      


Gly Pro Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala 
            20                  25                  30          


Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn 
        35                  40                  45              


Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr 
    50                  55                  60                  


Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe 
65                  70                  75                  80  


Thr Asn Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg 
                85                  90                  95      


Gln Ile Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys 
            100                 105                 110         


Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn 
        115                 120                 125             


Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe 
    130                 135                 140                 


Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile 
145                 150                 155                 160 


Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys 
                165                 170                 175     


Tyr Phe Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly 
            180                 185                 190         


Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala 
        195                 200                 205             


Pro Ala Thr Val Cys Gly Pro Gly Ser Gly Gly Gly Gly Met Gln Ile 
    210                 215                 220                 


Tyr Glu Gly Lys Leu Thr Ala Glu Gly Leu Arg Phe Gly Ile Val Ala 
225                 230                 235                 240 


Ser Arg Phe Asn His Ala Leu Val Asp Arg Leu Val Glu Gly Ala Ile 
                245                 250                 255     


Asp Ala Ile Val Arg His Gly Gly Arg Glu Glu Asp Ile Thr Leu Val 
            260                 265                 270         


Arg Val Pro Gly Ser Trp Glu Ile Pro Val Ala Ala Gly Glu Leu Ala 
        275                 280                 285             


Arg Lys Glu Asp Ile Asp Ala Val Ile Ala Ile Gly Val Leu Ile Arg 
    290                 295                 300                 


Gly Ala Thr Pro His Phe Asp Tyr Ile Ala Ser Glu Val Ser Lys Gly 
305                 310                 315                 320 


Leu Ala Asp Leu Ser Leu Glu Leu Arg Lys Pro Ile Thr Phe Gly Val 
                325                 330                 335     


Ile Thr Ala Asp Thr Leu Glu Gln Ala Ile Glu Arg Ala Gly Thr Lys 
            340                 345                 350         


His Gly Asn Lys Gly Trp Glu Ala Ala Leu Ser Ala Ile Glu Met Ala 
        355                 360                 365             


Asn Leu Phe Lys Ser Leu Arg 
    370                 375 


<210> 31
<211> 414
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 31
Met Gln Ile Tyr Glu Gly Lys Leu Thr Ala Glu Gly Leu Arg Phe Gly 
1               5                   10                  15      


Ile Val Ala Ser Arg Phe Asn His Ala Leu Val Asp Arg Leu Val Glu 
            20                  25                  30          


Gly Ala Ile Asp Ala Ile Val Arg His Gly Gly Arg Glu Glu Asp Ile 
        35                  40                  45              


Thr Leu Val Arg Val Pro Gly Ser Trp Glu Ile Pro Val Ala Ala Gly 
    50                  55                  60                  


Glu Leu Ala Arg Lys Glu Asp Ile Asp Ala Val Ile Ala Ile Gly Val 
65                  70                  75                  80  


Leu Ile Arg Gly Ala Thr Pro His Phe Asp Tyr Ile Ala Ser Glu Val 
                85                  90                  95      


Ser Lys Gly Leu Ala Asp Leu Ser Leu Glu Leu Arg Lys Pro Ile Thr 
            100                 105                 110         


Phe Gly Val Ile Thr Ala Asp Thr Leu Glu Gln Ala Ile Glu Arg Ala 
        115                 120                 125             


Gly Thr Lys His Gly Asn Lys Gly Trp Glu Ala Ala Leu Ser Ala Ile 
    130                 135                 140                 


Glu Met Ala Asn Leu Phe Lys Ser Leu Arg Gly Gly Ser Gly Gly Ser 
145                 150                 155                 160 


Gly Gly Ser Gly Gly Ser Gly Gly Gly Asn Ile Thr Asn Leu Cys Pro 
                165                 170                 175     


Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala Trp 
            180                 185                 190         


Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr 
        195                 200                 205             


Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro Thr 
    210                 215                 220                 


Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe Val 
225                 230                 235                 240 


Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly Lys 
                245                 250                 255     


Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys Val 
            260                 265                 270         


Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn Tyr 
        275                 280                 285             


Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu 
    290                 295                 300                 


Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys Asn 
305                 310                 315                 320 


Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly Phe 
                325                 330                 335     


Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val Leu 
            340                 345                 350         


Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Leu Glu 
        355                 360                 365             


Val Leu Phe Gln Gly Pro Ser Ala Trp Ser His Pro Gln Phe Glu Lys 
    370                 375                 380                 


Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Ser Ala Trp Ser His Pro 
385                 390                 395                 400 


Gln Phe Glu Lys Gly Ser His His His His His His His His 
                405                 410                 


<210> 32
<211> 487
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 32
His His His His His His His His Gly Pro Leu Glu Val Leu Phe Gln 
1               5                   10                  15      


Gly Pro Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr 
            20                  25                  30          


Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser 
        35                  40                  45              


Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn 
    50                  55                  60                  


Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys 
65                  70                  75                  80  


Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala 
                85                  90                  95      


Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr 
            100                 105                 110         


Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn 
        115                 120                 125             


Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu 
    130                 135                 140                 


Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe 
145                 150                 155                 160 


Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln 
                165                 170                 175     


Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu 
            180                 185                 190         


Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser 
        195                 200                 205             


Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser 
    210                 215                 220                 


Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg 
225                 230                 235                 240 


Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp 
                245                 250                 255     


Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr 
            260                 265                 270         


Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile 
        275                 280                 285             


Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys 
    290                 295                 300                 


Thr Leu Gly Ser Gly Gly Gly Gly Glu Ser Gln Val Arg Gln Gln Phe 
305                 310                 315                 320 


Ser Lys Asp Ile Glu Lys Leu Leu Asn Glu Gln Val Asn Lys Glu Met 
                325                 330                 335     


Gln Ser Ser Asn Leu Tyr Met Ser Met Ser Ser Trp Cys Tyr Thr His 
            340                 345                 350         


Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp His Ala Ala Glu Glu 
        355                 360                 365             


Tyr Glu His Ala Lys Lys Leu Ile Ile Phe Leu Asn Glu Asn Asn Val 
    370                 375                 380                 


Pro Val Gln Leu Thr Ser Ile Ser Ala Pro Glu His Lys Phe Glu Gly 
385                 390                 395                 400 


Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu His Glu Gln His Ile Ser 
                405                 410                 415     


Glu Ser Ile Asn Asn Ile Val Asp His Ala Ile Lys Ser Lys Asp His 
            420                 425                 430         


Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala Glu Gln His Glu Glu 
        435                 440                 445             


Glu Val Leu Phe Lys Asp Ile Leu Asp Lys Ile Glu Leu Ile Gly Asn 
    450                 455                 460                 


Glu Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr Val Lys Gly Ile Ala 
465                 470                 475                 480 


Lys Ser Arg Lys Ser Gly Ser 
                485         


<210> 33
<211> 393
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 33
His His His His His His His His Gly Pro Leu Glu Val Leu Phe Gln 
1               5                   10                  15      


Gly Pro Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala 
            20                  25                  30          


Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn 
        35                  40                  45              


Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr 
    50                  55                  60                  


Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe 
65                  70                  75                  80  


Thr Asn Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg 
                85                  90                  95      


Gln Ile Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys 
            100                 105                 110         


Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn 
        115                 120                 125             


Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe 
    130                 135                 140                 


Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile 
145                 150                 155                 160 


Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys 
                165                 170                 175     


Tyr Phe Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly 
            180                 185                 190         


Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala 
        195                 200                 205             


Pro Ala Thr Val Cys Gly Gly Ser Gly Gly Glu Ser Gln Val Arg Gln 
    210                 215                 220                 


Gln Phe Ser Lys Asp Ile Glu Lys Leu Leu Asn Glu Gln Val Asn Lys 
225                 230                 235                 240 


Glu Met Gln Ser Ser Asn Leu Tyr Met Ser Met Ser Ser Trp Cys Tyr 
                245                 250                 255     


Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp His Ala Ala 
            260                 265                 270         


Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe Leu Asn Glu Asn 
        275                 280                 285             


Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro Glu His Lys Phe 
    290                 295                 300                 


Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu His Glu Gln His 
305                 310                 315                 320 


Ile Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala Ile Lys Ser Lys 
                325                 330                 335     


Asp His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala Glu Gln His 
            340                 345                 350         


Glu Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys Ile Glu Leu Ile 
        355                 360                 365             


Gly Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr Val Lys Gly 
    370                 375                 380                 


Ile Ala Lys Ser Arg Lys Ser Gly Ser 
385                 390             


<210> 34
<211> 383
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 34
His His His His His His His His Gly Pro Leu Glu Val Leu Phe Gln 
1               5                   10                  15      


Gly Pro Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala 
            20                  25                  30          


Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn 
        35                  40                  45              


Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr 
    50                  55                  60                  


Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe 
65                  70                  75                  80  


Thr Asn Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg 
                85                  90                  95      


Gln Ile Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys 
            100                 105                 110         


Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn 
        115                 120                 125             


Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe 
    130                 135                 140                 


Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile 
145                 150                 155                 160 


Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys 
                165                 170                 175     


Tyr Phe Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly 
            180                 185                 190         


Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala 
        195                 200                 205             


Pro Ala Thr Val Cys Gly Gly Ser Gly Gly Asp Ile Ile Lys Leu Leu 
    210                 215                 220                 


Asn Glu Gln Val Asn Lys Glu Met Gln Ser Ser Asn Leu Tyr Met Ser 
225                 230                 235                 240 


Met Ser Ser Trp Cys Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe 
                245                 250                 255     


Leu Phe Asp His Ala Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile 
            260                 265                 270         


Ile Phe Leu Asn Glu Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser 
        275                 280                 285             


Ala Pro Glu His Lys Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala 
    290                 295                 300                 


Tyr Glu His Glu Gln His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp 
305                 310                 315                 320 


His Ala Ile Lys Ser Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp 
                325                 330                 335     


Tyr Val Ala Glu Gln His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu 
            340                 345                 350         


Asp Lys Ile Glu Leu Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala 
        355                 360                 365             


Asp Gln Tyr Val Lys Gly Ile Ala Lys Ser Arg Lys Ser Gly Ser 
    370                 375                 380             


<210> 35
<211> 388
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 35
His His His His His His His His Gly Pro Leu Glu Val Leu Phe Gln 
1               5                   10                  15      


Gly Pro Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala 
            20                  25                  30          


Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn 
        35                  40                  45              


Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr 
    50                  55                  60                  


Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe 
65                  70                  75                  80  


Thr Asn Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg 
                85                  90                  95      


Gln Ile Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys 
            100                 105                 110         


Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn 
        115                 120                 125             


Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe 
    130                 135                 140                 


Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile 
145                 150                 155                 160 


Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys 
                165                 170                 175     


Tyr Phe Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly 
            180                 185                 190         


Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala 
        195                 200                 205             


Pro Ala Thr Val Cys Gly Gly Gly Ser Gly Gly Gly Gly Ser Lys Asp 
    210                 215                 220                 


Ile Ile Lys Leu Leu Asn Glu Gln Val Asn Lys Glu Met Gln Ser Ser 
225                 230                 235                 240 


Asn Leu Tyr Met Ser Met Ser Ser Trp Cys Tyr Thr His Ser Leu Asp 
                245                 250                 255     


Gly Ala Gly Leu Phe Leu Phe Asp His Ala Ala Glu Glu Tyr Glu His 
            260                 265                 270         


Ala Lys Lys Leu Ile Ile Phe Leu Asn Glu Asn Asn Val Pro Val Gln 
        275                 280                 285             


Leu Thr Ser Ile Ser Ala Pro Glu His Lys Phe Glu Gly Leu Thr Gln 
    290                 295                 300                 


Ile Phe Gln Lys Ala Tyr Glu His Glu Gln His Ile Ser Glu Ser Ile 
305                 310                 315                 320 


Asn Asn Ile Val Asp His Ala Ile Lys Ser Lys Asp His Ala Thr Phe 
                325                 330                 335     


Asn Phe Leu Gln Trp Tyr Val Ala Glu Gln His Glu Glu Glu Val Leu 
            340                 345                 350         


Phe Lys Asp Ile Leu Asp Lys Ile Glu Leu Ile Gly Asn Glu Asn His 
        355                 360                 365             


Gly Leu Tyr Leu Ala Asp Gln Tyr Val Lys Gly Ile Ala Lys Ser Arg 
    370                 375                 380                 


Lys Ser Gly Ser 
385             


<210> 36
<211> 472
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 36
His His His His His His His His Gly Pro Leu Glu Val Leu Phe Gln 
1               5                   10                  15      


Gly Pro Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile 
            20                  25                  30          


Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala 
        35                  40                  45              


Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp 
    50                  55                  60                  


Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr 
65                  70                  75                  80  


Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr 
                85                  90                  95      


Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro 
            100                 105                 110         


Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp 
        115                 120                 125             


Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys 
    130                 135                 140                 


Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn 
145                 150                 155                 160 


Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly 
                165                 170                 175     


Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu 
            180                 185                 190         


Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr 
        195                 200                 205             


Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val 
    210                 215                 220                 


Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn 
225                 230                 235                 240 


Phe Asn Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn 
                245                 250                 255     


Lys Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr 
            260                 265                 270         


Thr Asp Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr 
        275                 280                 285             


Pro Cys Ser Gly Ser Gly Gly Gly Gly Glu Ser Gln Val Arg Gln Gln 
    290                 295                 300                 


Phe Ser Lys Asp Ile Glu Lys Leu Leu Asn Glu Gln Val Asn Lys Glu 
305                 310                 315                 320 


Met Gln Ser Ser Asn Leu Tyr Met Ser Met Ser Ser Trp Cys Tyr Thr 
                325                 330                 335     


His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp His Ala Ala Glu 
            340                 345                 350         


Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe Leu Asn Glu Asn Asn 
        355                 360                 365             


Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro Glu His Lys Phe Glu 
    370                 375                 380                 


Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu His Glu Gln His Ile 
385                 390                 395                 400 


Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala Ile Lys Ser Lys Asp 
                405                 410                 415     


His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala Glu Gln His Glu 
            420                 425                 430         


Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys Ile Glu Leu Ile Gly 
        435                 440                 445             


Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr Val Lys Gly Ile 
    450                 455                 460                 


Ala Lys Ser Arg Lys Ser Gly Ser 
465                 470         


<210> 37
<211> 175
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 37
Glu Ser Gln Val Arg Gln Gln Phe Ser Lys Asp Ile Glu Lys Leu Leu 
1               5                   10                  15      


Asn Glu Gln Val Asn Lys Glu Met Gln Ser Ser Asn Leu Tyr Met Ser 
            20                  25                  30          


Met Ser Ser Trp Cys Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe 
        35                  40                  45              


Leu Phe Asp His Ala Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile 
    50                  55                  60                  


Ile Phe Leu Asn Glu Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser 
65                  70                  75                  80  


Ala Pro Glu His Lys Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala 
                85                  90                  95      


Tyr Glu His Glu Gln His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp 
            100                 105                 110         


His Ala Ile Lys Ser Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp 
        115                 120                 125             


Tyr Val Ala Glu Gln His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu 
    130                 135                 140                 


Asp Lys Ile Glu Leu Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala 
145                 150                 155                 160 


Asp Gln Tyr Val Lys Gly Ile Ala Lys Ser Arg Lys Ser Gly Ser 
                165                 170                 175 


<210> 38
<211> 466
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 38
His His His His His His His His Gly Pro Leu Glu Val Leu Phe Gln 
1               5                   10                  15      


Gly Pro Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr 
            20                  25                  30          


Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser 
        35                  40                  45              


Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn 
    50                  55                  60                  


Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys 
65                  70                  75                  80  


Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala 
                85                  90                  95      


Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr 
            100                 105                 110         


Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn 
        115                 120                 125             


Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu 
    130                 135                 140                 


Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe 
145                 150                 155                 160 


Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln 
                165                 170                 175     


Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu 
            180                 185                 190         


Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser 
        195                 200                 205             


Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser 
    210                 215                 220                 


Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg 
225                 230                 235                 240 


Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp 
                245                 250                 255     


Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr 
            260                 265                 270         


Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile 
        275                 280                 285             


Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys 
    290                 295                 300                 


Thr Leu Gly Ser Gly Gly Gly Gly Met Gln Ile Tyr Glu Gly Lys Leu 
305                 310                 315                 320 


Thr Ala Glu Gly Leu Arg Phe Gly Ile Val Ala Ser Arg Phe Asn His 
                325                 330                 335     


Ala Leu Val Asp Arg Leu Val Glu Gly Ala Ile Asp Ala Ile Val Arg 
            340                 345                 350         


His Gly Gly Arg Glu Glu Asp Ile Thr Leu Val Arg Val Pro Gly Ser 
        355                 360                 365             


Trp Glu Ile Pro Val Ala Ala Gly Glu Leu Ala Arg Lys Glu Asp Ile 
    370                 375                 380                 


Asp Ala Val Ile Ala Ile Gly Val Leu Ile Arg Gly Ala Thr Pro His 
385                 390                 395                 400 


Phe Asp Tyr Ile Ala Ser Glu Val Ser Lys Gly Leu Ala Asp Leu Ser 
                405                 410                 415     


Leu Glu Leu Arg Lys Pro Ile Thr Phe Gly Val Ile Thr Ala Asp Thr 
            420                 425                 430         


Leu Glu Gln Ala Ile Glu Arg Ala Gly Thr Lys His Gly Asn Lys Gly 
        435                 440                 445             


Trp Glu Ala Ala Leu Ser Ala Ile Glu Met Ala Asn Leu Phe Lys Ser 
    450                 455                 460                 


Leu Arg 
465     


<210> 39
<211> 475
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 39
Met Gln Ile Tyr Glu Gly Lys Leu Thr Ala Glu Gly Leu Arg Phe Gly 
1               5                   10                  15      


Ile Val Ala Ser Arg Phe Asn His Ala Leu Val Asp Arg Leu Val Glu 
            20                  25                  30          


Gly Ala Ile Asp Ala Ile Val Arg His Gly Gly Arg Glu Glu Asp Ile 
        35                  40                  45              


Thr Leu Val Arg Val Pro Gly Ser Trp Glu Ile Pro Val Ala Ala Gly 
    50                  55                  60                  


Glu Leu Ala Arg Lys Glu Asp Ile Asp Ala Val Ile Ala Ile Gly Val 
65                  70                  75                  80  


Leu Ile Arg Gly Ala Thr Pro His Phe Asp Tyr Ile Ala Ser Glu Val 
                85                  90                  95      


Ser Lys Gly Leu Ala Asp Leu Ser Leu Glu Leu Arg Lys Pro Ile Thr 
            100                 105                 110         


Phe Gly Val Ile Thr Ala Asp Thr Leu Glu Gln Ala Ile Glu Arg Ala 
        115                 120                 125             


Gly Thr Lys His Gly Asn Lys Gly Trp Glu Ala Ala Leu Ser Ala Ile 
    130                 135                 140                 


Glu Met Ala Asn Leu Phe Lys Ser Leu Arg Gly Gly Ser Gly Gly Ser 
145                 150                 155                 160 


Gly Gly Ser Gly Gly Ser Gly Gly Gly Val Asn Leu Thr Thr Arg Thr 
                165                 170                 175     


Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr 
            180                 185                 190         


Pro Asp Lys Val Phe Arg Ser Ser Val Leu His Ser Thr Gln Asp Leu 
        195                 200                 205             


Phe Leu Pro Phe Phe Ser Asn Val Thr Trp Phe His Ala Ile His Val 
    210                 215                 220                 


Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp Asn Pro Val Leu Pro Phe 
225                 230                 235                 240 


Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg 
                245                 250                 255     


Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu 
            260                 265                 270         


Ile Val Asn Asn Ala Thr Asn Val Val Ile Lys Val Cys Glu Phe Gln 
        275                 280                 285             


Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr Tyr His Lys Asn Asn Lys 
    290                 295                 300                 


Ser Trp Met Glu Ser Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys 
305                 310                 315                 320 


Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu Met Asp Leu Glu Gly Lys 
                325                 330                 335     


Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe Val Phe Lys Asn Ile Asp 
            340                 345                 350         


Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr Pro Ile Asn Leu Val Arg 
        355                 360                 365             


Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu Pro Leu Val Asp Leu Pro 
    370                 375                 380                 


Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr Leu Leu Ala Leu His Arg 
385                 390                 395                 400 


Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser Gly Trp Thr Ala Gly Ala 
                405                 410                 415     


Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro Arg Thr Phe Leu Leu Lys 
            420                 425                 430         


Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala Val Asp Cys Ala Leu Asp 
        435                 440                 445             


Pro Leu Ser Glu Thr Lys Cys Thr Leu Gly Ser Leu Glu Val Leu Phe 
    450                 455                 460                 


Gln Gly Pro His His His His His His His His 
465                 470                 475 


<210> 40
<211> 375
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 40
Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg 
1               5                   10                  15      


Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val 
            20                  25                  30          


Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys 
        35                  40                  45              


Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn 
    50                  55                  60                  


Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile 
65                  70                  75                  80  


Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro 
                85                  90                  95      


Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp 
            100                 105                 110         


Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys 
        115                 120                 125             


Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln 
    130                 135                 140                 


Ala Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe 
145                 150                 155                 160 


Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln 
                165                 170                 175     


Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala 
            180                 185                 190         


Thr Val Cys Gly Gly Ser Gly Gly Glu Ser Gln Val Arg Gln Gln Phe 
        195                 200                 205             


Ser Lys Asp Ile Glu Lys Leu Leu Asn Glu Gln Val Asn Lys Glu Met 
    210                 215                 220                 


Gln Ser Ser Asn Leu Tyr Met Ser Met Ser Ser Trp Cys Tyr Thr His 
225                 230                 235                 240 


Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp His Ala Ala Glu Glu 
                245                 250                 255     


Tyr Glu His Ala Lys Lys Leu Ile Ile Phe Leu Asn Glu Asn Asn Val 
            260                 265                 270         


Pro Val Gln Leu Thr Ser Ile Ser Ala Pro Glu His Lys Phe Glu Gly 
        275                 280                 285             


Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu His Glu Gln His Ile Ser 
    290                 295                 300                 


Glu Ser Ile Asn Asn Ile Val Asp His Ala Ile Lys Ser Lys Asp His 
305                 310                 315                 320 


Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala Glu Gln His Glu Glu 
                325                 330                 335     


Glu Val Leu Phe Lys Asp Ile Leu Asp Lys Ile Glu Leu Ile Gly Asn 
            340                 345                 350         


Glu Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr Val Lys Gly Ile Ala 
        355                 360                 365             


Lys Ser Arg Lys Ser Gly Ser 
    370                 375 


<210> 41
<211> 365
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 41
Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg 
1               5                   10                  15      


Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val 
            20                  25                  30          


Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys 
        35                  40                  45              


Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn 
    50                  55                  60                  


Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile 
65                  70                  75                  80  


Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro 
                85                  90                  95      


Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp 
            100                 105                 110         


Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys 
        115                 120                 125             


Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln 
    130                 135                 140                 


Ala Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe 
145                 150                 155                 160 


Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln 
                165                 170                 175     


Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala 
            180                 185                 190         


Thr Val Cys Gly Gly Ser Gly Gly Asp Ile Ile Lys Leu Leu Asn Glu 
        195                 200                 205             


Gln Val Asn Lys Glu Met Gln Ser Ser Asn Leu Tyr Met Ser Met Ser 
    210                 215                 220                 


Ser Trp Cys Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe 
225                 230                 235                 240 


Asp His Ala Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe 
                245                 250                 255     


Leu Asn Glu Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro 
            260                 265                 270         


Glu His Lys Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu 
        275                 280                 285             


His Glu Gln His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala 
    290                 295                 300                 


Ile Lys Ser Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val 
305                 310                 315                 320 


Ala Glu Gln His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys 
                325                 330                 335     


Ile Glu Leu Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln 
            340                 345                 350         


Tyr Val Lys Gly Ile Ala Lys Ser Arg Lys Ser Gly Ser 
        355                 360                 365 


<210> 42
<211> 464
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 42
His His His His His His His His Gly Pro Leu Glu Val Leu Phe Gln 
1               5                   10                  15      


Gly Pro Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile 
            20                  25                  30          


Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala 
        35                  40                  45              


Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp 
    50                  55                  60                  


Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr 
65                  70                  75                  80  


Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr 
                85                  90                  95      


Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro 
            100                 105                 110         


Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp 
        115                 120                 125             


Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys 
    130                 135                 140                 


Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn 
145                 150                 155                 160 


Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly 
                165                 170                 175     


Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu 
            180                 185                 190         


Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr 
        195                 200                 205             


Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val 
    210                 215                 220                 


Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn 
225                 230                 235                 240 


Phe Asn Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn 
                245                 250                 255     


Lys Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr 
            260                 265                 270         


Thr Asp Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr 
        275                 280                 285             


Pro Cys Ser Gly Ser Gly Gly Gly Gly Ser Lys Asp Ile Ile Lys Leu 
    290                 295                 300                 


Leu Asn Glu Gln Val Asn Lys Glu Met Gln Ser Ser Asn Leu Tyr Met 
305                 310                 315                 320 


Ser Met Ser Ser Trp Cys Tyr Thr His Ser Leu Asp Gly Ala Gly Leu 
                325                 330                 335     


Phe Leu Phe Asp His Ala Ala Glu Glu Tyr Glu His Ala Lys Lys Leu 
            340                 345                 350         


Ile Ile Phe Leu Asn Glu Asn Asn Val Pro Val Gln Leu Thr Ser Ile 
        355                 360                 365             


Ser Ala Pro Glu His Lys Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys 
    370                 375                 380                 


Ala Tyr Glu His Glu Gln His Ile Ser Glu Ser Ile Asn Asn Ile Val 
385                 390                 395                 400 


Asp His Ala Ile Lys Ser Lys Asp His Ala Thr Phe Asn Phe Leu Gln 
                405                 410                 415     


Trp Tyr Val Ala Glu Gln His Glu Glu Glu Val Leu Phe Lys Asp Ile 
            420                 425                 430         


Leu Asp Lys Ile Glu Leu Ile Gly Asn Glu Asn His Gly Leu Tyr Leu 
        435                 440                 445             


Ala Asp Gln Tyr Val Lys Gly Ile Ala Lys Ser Arg Lys Ser Gly Ser 
    450                 455                 460                 


<210> 43
<211> 409
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 43
His His His His His His His His Gly Pro Leu Glu Val Leu Phe Gln 
1               5                   10                  15      


Gly Pro Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala 
            20                  25                  30          


Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn 
        35                  40                  45              


Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr 
    50                  55                  60                  


Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe 
65                  70                  75                  80  


Thr Asn Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg 
                85                  90                  95      


Gln Ile Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys 
            100                 105                 110         


Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn 
        115                 120                 125             


Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe 
    130                 135                 140                 


Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile 
145                 150                 155                 160 


Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys 
                165                 170                 175     


Tyr Phe Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly 
            180                 185                 190         


Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala 
        195                 200                 205             


Pro Ala Thr Val Cys Gly Gly Ser Gly Gly Pro Pro Pro Pro Pro Pro 
    210                 215                 220                 


Pro Pro Pro Pro Gly Ser Gly Gly Gly Gly Glu Ser Gln Val Arg Gln 
225                 230                 235                 240 


Gln Phe Ser Lys Asp Ile Glu Lys Leu Leu Asn Glu Gln Val Asn Lys 
                245                 250                 255     


Glu Met Gln Ser Ser Asn Leu Tyr Met Ser Met Ser Ser Trp Cys Tyr 
            260                 265                 270         


Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp His Ala Ala 
        275                 280                 285             


Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe Leu Asn Glu Asn 
    290                 295                 300                 


Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro Glu His Lys Phe 
305                 310                 315                 320 


Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu His Glu Gln His 
                325                 330                 335     


Ile Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala Ile Lys Ser Lys 
            340                 345                 350         


Asp His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala Glu Gln His 
        355                 360                 365             


Glu Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys Ile Glu Leu Ile 
    370                 375                 380                 


Gly Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr Val Lys Gly 
385                 390                 395                 400 


Ile Ala Lys Ser Arg Lys Ser Gly Ser 
                405                 


<210> 44
<211> 410
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 44
His His His His His His His His Gly Pro Leu Glu Val Leu Phe Gln 
1               5                   10                  15      


Gly Pro Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala 
            20                  25                  30          


Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn 
        35                  40                  45              


Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr 
    50                  55                  60                  


Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe 
65                  70                  75                  80  


Thr Asn Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg 
                85                  90                  95      


Gln Ile Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys 
            100                 105                 110         


Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn 
        115                 120                 125             


Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe 
    130                 135                 140                 


Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile 
145                 150                 155                 160 


Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys 
                165                 170                 175     


Tyr Phe Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly 
            180                 185                 190         


Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala 
        195                 200                 205             


Pro Ala Thr Val Cys Gly Gly Ser Gly Gly Glu Lys Asp Ser His Lys 
    210                 215                 220                 


Glu Glu Lys Asp Ser His Lys Gly Ser Gly Gly Glu Ser Gln Val Arg 
225                 230                 235                 240 


Gln Gln Phe Ser Lys Asp Ile Glu Lys Leu Leu Asn Glu Gln Val Asn 
                245                 250                 255     


Lys Glu Met Gln Ser Ser Asn Leu Tyr Met Ser Met Ser Ser Trp Cys 
            260                 265                 270         


Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp His Ala 
        275                 280                 285             


Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe Leu Asn Glu 
    290                 295                 300                 


Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro Glu His Lys 
305                 310                 315                 320 


Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu His Glu Gln 
                325                 330                 335     


His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala Ile Lys Ser 
            340                 345                 350         


Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala Glu Gln 
        355                 360                 365             


His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys Ile Glu Leu 
    370                 375                 380                 


Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr Val Lys 
385                 390                 395                 400 


Gly Ile Ala Lys Ser Arg Lys Ser Gly Ser 
                405                 410 


<210> 45
<211> 412
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 45
His His His His His His His His Gly Pro Leu Glu Val Leu Phe Gln 
1               5                   10                  15      


Gly Pro Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala 
            20                  25                  30          


Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn 
        35                  40                  45              


Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr 
    50                  55                  60                  


Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe 
65                  70                  75                  80  


Thr Asn Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg 
                85                  90                  95      


Gln Ile Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys 
            100                 105                 110         


Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn 
        115                 120                 125             


Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe 
    130                 135                 140                 


Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile 
145                 150                 155                 160 


Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys 
                165                 170                 175     


Tyr Phe Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly 
            180                 185                 190         


Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala 
        195                 200                 205             


Pro Ala Thr Val Cys Gly Gly Ser Gly Gly Glu Asp Asn Ala Gln His 
    210                 215                 220                 


Thr Ser Ala Asp Asn Glu Ala Thr Lys Gly Ser Gly Gly Glu Ser Gln 
225                 230                 235                 240 


Val Arg Gln Gln Phe Ser Lys Asp Ile Glu Lys Leu Leu Asn Glu Gln 
                245                 250                 255     


Val Asn Lys Glu Met Gln Ser Ser Asn Leu Tyr Met Ser Met Ser Ser 
            260                 265                 270         


Trp Cys Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp 
        275                 280                 285             


His Ala Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe Leu 
    290                 295                 300                 


Asn Glu Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro Glu 
305                 310                 315                 320 


His Lys Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu His 
                325                 330                 335     


Glu Gln His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala Ile 
            340                 345                 350         


Lys Ser Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala 
        355                 360                 365             


Glu Gln His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys Ile 
    370                 375                 380                 


Glu Leu Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr 
385                 390                 395                 400 


Val Lys Gly Ile Ala Lys Ser Arg Lys Ser Gly Ser 
                405                 410         


<210> 46
<211> 423
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 46
His His His His His His His His Gly Pro Leu Glu Val Leu Phe Gln 
1               5                   10                  15      


Gly Pro Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala 
            20                  25                  30          


Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn 
        35                  40                  45              


Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr 
    50                  55                  60                  


Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe 
65                  70                  75                  80  


Thr Asn Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg 
                85                  90                  95      


Gln Ile Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys 
            100                 105                 110         


Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn 
        115                 120                 125             


Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe 
    130                 135                 140                 


Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile 
145                 150                 155                 160 


Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys 
                165                 170                 175     


Tyr Phe Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly 
            180                 185                 190         


Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala 
        195                 200                 205             


Pro Ala Thr Val Cys Gly Gly Ser Gly Ser Gly Gly Glu Met Lys Gln 
    210                 215                 220                 


Ile Glu Asp Lys Ile Glu Glu Ile Leu Ser Lys Ile Tyr His Ile Glu 
225                 230                 235                 240 


Asn Glu Ile Ala Arg Ile Lys Lys Leu Ile Gly Arg Gly Ser Gly Gly 
                245                 250                 255     


Ser Gly Asp Ile Ile Lys Leu Leu Asn Glu Gln Val Asn Lys Glu Met 
            260                 265                 270         


Gln Ser Ser Asn Leu Tyr Met Ser Met Ser Ser Trp Cys Tyr Thr His 
        275                 280                 285             


Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp His Ala Ala Glu Glu 
    290                 295                 300                 


Tyr Glu His Ala Lys Lys Leu Ile Ile Phe Leu Asn Glu Asn Asn Val 
305                 310                 315                 320 


Pro Val Gln Leu Thr Ser Ile Ser Ala Pro Glu His Lys Phe Glu Gly 
                325                 330                 335     


Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu His Glu Gln His Ile Ser 
            340                 345                 350         


Glu Ser Ile Asn Asn Ile Val Asp His Ala Ile Lys Ser Lys Asp His 
        355                 360                 365             


Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala Glu Gln His Glu Glu 
    370                 375                 380                 


Glu Val Leu Phe Lys Asp Ile Leu Asp Lys Ile Glu Leu Ile Gly Asn 
385                 390                 395                 400 


Glu Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr Val Lys Gly Ile Ala 
                405                 410                 415     


Lys Ser Arg Lys Ser Gly Ser 
            420             


<210> 47
<211> 406
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 47
His His His His His His His His Gly Pro Leu Glu Val Leu Phe Gln 
1               5                   10                  15      


Gly Pro Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala 
            20                  25                  30          


Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn 
        35                  40                  45              


Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr 
    50                  55                  60                  


Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe 
65                  70                  75                  80  


Thr Asn Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg 
                85                  90                  95      


Gln Ile Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys 
            100                 105                 110         


Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn 
        115                 120                 125             


Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe 
    130                 135                 140                 


Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile 
145                 150                 155                 160 


Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys 
                165                 170                 175     


Tyr Phe Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly 
            180                 185                 190         


Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala 
        195                 200                 205             


Pro Ala Thr Val Cys Gly Gly Ser Gly Ser Gly Gly Glu Leu Gln Ser 
    210                 215                 220                 


Glu Leu Asp Ser Ile Lys Glu Glu Leu Asp Lys Gly Ser Gly Gly Ser 
225                 230                 235                 240 


Gly Asp Ile Ile Lys Leu Leu Asn Glu Gln Val Asn Lys Glu Met Gln 
                245                 250                 255     


Ser Ser Asn Leu Tyr Met Ser Met Ser Ser Trp Cys Tyr Thr His Ser 
            260                 265                 270         


Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp His Ala Ala Glu Glu Tyr 
        275                 280                 285             


Glu His Ala Lys Lys Leu Ile Ile Phe Leu Asn Glu Asn Asn Val Pro 
    290                 295                 300                 


Val Gln Leu Thr Ser Ile Ser Ala Pro Glu His Lys Phe Glu Gly Leu 
305                 310                 315                 320 


Thr Gln Ile Phe Gln Lys Ala Tyr Glu His Glu Gln His Ile Ser Glu 
                325                 330                 335     


Ser Ile Asn Asn Ile Val Asp His Ala Ile Lys Ser Lys Asp His Ala 
            340                 345                 350         


Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala Glu Gln His Glu Glu Glu 
        355                 360                 365             


Val Leu Phe Lys Asp Ile Leu Asp Lys Ile Glu Leu Ile Gly Asn Glu 
    370                 375                 380                 


Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr Val Lys Gly Ile Ala Lys 
385                 390                 395                 400 


Ser Arg Lys Ser Gly Ser 
                405     


<210> 48
<211> 424
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 48
His His His His His His His His Gly Pro Leu Glu Val Leu Phe Gln 
1               5                   10                  15      


Gly Pro Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala 
            20                  25                  30          


Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn 
        35                  40                  45              


Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr 
    50                  55                  60                  


Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe 
65                  70                  75                  80  


Thr Asn Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg 
                85                  90                  95      


Gln Ile Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys 
            100                 105                 110         


Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn 
        115                 120                 125             


Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe 
    130                 135                 140                 


Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile 
145                 150                 155                 160 


Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys 
                165                 170                 175     


Tyr Phe Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly 
            180                 185                 190         


Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala 
        195                 200                 205             


Pro Ala Thr Val Cys Gly Gly Ser Gly Ser Gly Gly Glu Leu Gln Ser 
    210                 215                 220                 


Glu Leu Asp Ser Ile Lys Glu Glu Leu Asp Lys Ile His Lys Asn Leu 
225                 230                 235                 240 


Asp Ser Ile Lys Glu Glu Leu Asp Lys Ile His Lys Asn Gly Ser Gly 
                245                 250                 255     


Gly Ser Gly Asp Ile Ile Lys Leu Leu Asn Glu Gln Val Asn Lys Glu 
            260                 265                 270         


Met Gln Ser Ser Asn Leu Tyr Met Ser Met Ser Ser Trp Cys Tyr Thr 
        275                 280                 285             


His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp His Ala Ala Glu 
    290                 295                 300                 


Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe Leu Asn Glu Asn Asn 
305                 310                 315                 320 


Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro Glu His Lys Phe Glu 
                325                 330                 335     


Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu His Glu Gln His Ile 
            340                 345                 350         


Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala Ile Lys Ser Lys Asp 
        355                 360                 365             


His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala Glu Gln His Glu 
    370                 375                 380                 


Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys Ile Glu Leu Ile Gly 
385                 390                 395                 400 


Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr Val Lys Gly Ile 
                405                 410                 415     


Ala Lys Ser Arg Lys Ser Gly Ser 
            420                 


<210> 49
<211> 396
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 49
His His His His His His His His Gly Pro Leu Glu Val Leu Phe Gln 
1               5                   10                  15      


Gly Pro Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala 
            20                  25                  30          


Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn 
        35                  40                  45              


Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr 
    50                  55                  60                  


Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe 
65                  70                  75                  80  


Thr Asn Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg 
                85                  90                  95      


Gln Ile Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys 
            100                 105                 110         


Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn 
        115                 120                 125             


Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Asn 
    130                 135                 140                 


Arg Thr Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile 
145                 150                 155                 160 


Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys 
                165                 170                 175     


Tyr Phe Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly 
            180                 185                 190         


Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala 
        195                 200                 205             


Pro Ala Thr Val Cys Gly Pro Gly Ser Gly Gly Gly Gly Glu Ser Gln 
    210                 215                 220                 


Val Arg Gln Gln Phe Ser Lys Asp Ile Glu Lys Leu Leu Asn Glu Gln 
225                 230                 235                 240 


Val Asn Lys Glu Met Gln Ser Ser Asn Leu Tyr Met Ser Met Ser Ser 
                245                 250                 255     


Trp Cys Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp 
            260                 265                 270         


His Ala Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe Leu 
        275                 280                 285             


Asn Glu Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro Glu 
    290                 295                 300                 


His Lys Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu His 
305                 310                 315                 320 


Glu Gln His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala Ile 
                325                 330                 335     


Lys Ser Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala 
            340                 345                 350         


Glu Gln His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys Ile 
        355                 360                 365             


Glu Leu Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr 
    370                 375                 380                 


Val Lys Gly Ile Ala Lys Ser Arg Lys Ser Gly Ser 
385                 390                 395     


<210> 50
<211> 396
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 50
His His His His His His His His Gly Pro Leu Glu Val Leu Phe Gln 
1               5                   10                  15      


Gly Pro Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala 
            20                  25                  30          


Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn 
        35                  40                  45              


Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr 
    50                  55                  60                  


Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe 
65                  70                  75                  80  


Thr Asn Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg 
                85                  90                  95      


Gln Ile Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys 
            100                 105                 110         


Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn 
        115                 120                 125             


Leu Asp Ser Lys Val Gly Gly Asn Lys Asn Tyr Leu Tyr Arg Arg Phe 
    130                 135                 140                 


Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile 
145                 150                 155                 160 


Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys 
                165                 170                 175     


Tyr Arg Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly 
            180                 185                 190         


Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala 
        195                 200                 205             


Pro Ala Thr Val Cys Gly Pro Gly Ser Gly Gly Gly Gly Glu Ser Gln 
    210                 215                 220                 


Val Arg Gln Gln Phe Ser Lys Asp Ile Glu Lys Leu Leu Asn Glu Gln 
225                 230                 235                 240 


Val Asn Lys Glu Met Gln Ser Ser Asn Leu Tyr Met Ser Met Ser Ser 
                245                 250                 255     


Trp Cys Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp 
            260                 265                 270         


His Ala Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe Leu 
        275                 280                 285             


Asn Glu Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro Glu 
    290                 295                 300                 


His Lys Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu His 
305                 310                 315                 320 


Glu Gln His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala Ile 
                325                 330                 335     


Lys Ser Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala 
            340                 345                 350         


Glu Gln His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys Ile 
        355                 360                 365             


Glu Leu Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr 
    370                 375                 380                 


Val Lys Gly Ile Ala Lys Ser Arg Lys Ser Gly Ser 
385                 390                 395     


<210> 51
<211> 396
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 51
His His His His His His His His Gly Pro Leu Glu Val Leu Phe Gln 
1               5                   10                  15      


Gly Pro Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala 
            20                  25                  30          


Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn 
        35                  40                  45              


Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr 
    50                  55                  60                  


Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe 
65                  70                  75                  80  


Thr Asn Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg 
                85                  90                  95      


Gln Ile Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys 
            100                 105                 110         


Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn 
        115                 120                 125             


Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Arg Phe 
    130                 135                 140                 


Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile 
145                 150                 155                 160 


Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys 
                165                 170                 175     


Tyr Phe Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly 
            180                 185                 190         


Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala 
        195                 200                 205             


Pro Ala Thr Val Cys Gly Pro Gly Ser Gly Gly Gly Gly Glu Ser Gln 
    210                 215                 220                 


Val Arg Gln Gln Phe Ser Lys Asp Ile Glu Lys Leu Leu Asn Glu Gln 
225                 230                 235                 240 


Val Asn Lys Glu Met Gln Ser Ser Asn Leu Tyr Met Ser Met Ser Ser 
                245                 250                 255     


Trp Cys Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp 
            260                 265                 270         


His Ala Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe Leu 
        275                 280                 285             


Asn Glu Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro Glu 
    290                 295                 300                 


His Lys Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu His 
305                 310                 315                 320 


Glu Gln His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala Ile 
                325                 330                 335     


Lys Ser Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala 
            340                 345                 350         


Glu Gln His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys Ile 
        355                 360                 365             


Glu Leu Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr 
    370                 375                 380                 


Val Lys Gly Ile Ala Lys Ser Arg Lys Ser Gly Ser 
385                 390                 395     


<210> 52
<211> 396
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 52
His His His His His His His His Gly Pro Leu Glu Val Leu Phe Gln 
1               5                   10                  15      


Gly Pro Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala 
            20                  25                  30          


Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn 
        35                  40                  45              


Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr 
    50                  55                  60                  


Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe 
65                  70                  75                  80  


Thr Asn Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg 
                85                  90                  95      


Gln Ile Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys 
            100                 105                 110         


Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn 
        115                 120                 125             


Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe 
    130                 135                 140                 


Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp Arg Ser Thr Glu Ile 
145                 150                 155                 160 


Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys 
                165                 170                 175     


Tyr Phe Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly 
            180                 185                 190         


Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala 
        195                 200                 205             


Pro Ala Thr Val Cys Gly Pro Gly Ser Gly Gly Gly Gly Glu Ser Gln 
    210                 215                 220                 


Val Arg Gln Gln Phe Ser Lys Asp Ile Glu Lys Leu Leu Asn Glu Gln 
225                 230                 235                 240 


Val Asn Lys Glu Met Gln Ser Ser Asn Leu Tyr Met Ser Met Ser Ser 
                245                 250                 255     


Trp Cys Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp 
            260                 265                 270         


His Ala Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe Leu 
        275                 280                 285             


Asn Glu Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro Glu 
    290                 295                 300                 


His Lys Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu His 
305                 310                 315                 320 


Glu Gln His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala Ile 
                325                 330                 335     


Lys Ser Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala 
            340                 345                 350         


Glu Gln His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys Ile 
        355                 360                 365             


Glu Leu Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr 
    370                 375                 380                 


Val Lys Gly Ile Ala Lys Ser Arg Lys Ser Gly Ser 
385                 390                 395     


<210> 53
<211> 396
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 53
His His His His His His His His Gly Pro Leu Glu Val Leu Phe Gln 
1               5                   10                  15      


Gly Pro Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala 
            20                  25                  30          


Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn 
        35                  40                  45              


Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr 
    50                  55                  60                  


Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe 
65                  70                  75                  80  


Thr Asn Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg 
                85                  90                  95      


Gln Ile Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys 
            100                 105                 110         


Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn 
        115                 120                 125             


Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Arg Arg Leu Phe 
    130                 135                 140                 


Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile 
145                 150                 155                 160 


Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys 
                165                 170                 175     


Tyr Phe Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly 
            180                 185                 190         


Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala 
        195                 200                 205             


Pro Ala Thr Val Cys Gly Pro Gly Ser Gly Gly Gly Gly Glu Ser Gln 
    210                 215                 220                 


Val Arg Gln Gln Phe Ser Lys Asp Ile Glu Lys Leu Leu Asn Glu Gln 
225                 230                 235                 240 


Val Asn Lys Glu Met Gln Ser Ser Asn Leu Tyr Met Ser Met Ser Ser 
                245                 250                 255     


Trp Cys Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp 
            260                 265                 270         


His Ala Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe Leu 
        275                 280                 285             


Asn Glu Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro Glu 
    290                 295                 300                 


His Lys Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu His 
305                 310                 315                 320 


Glu Gln His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala Ile 
                325                 330                 335     


Lys Ser Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala 
            340                 345                 350         


Glu Gln His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys Ile 
        355                 360                 365             


Glu Leu Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr 
    370                 375                 380                 


Val Lys Gly Ile Ala Lys Ser Arg Lys Ser Gly Ser 
385                 390                 395     


<210> 54
<211> 396
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 54
His His His His His His His His Gly Pro Leu Glu Val Leu Phe Gln 
1               5                   10                  15      


Gly Pro Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala 
            20                  25                  30          


Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn 
        35                  40                  45              


Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr 
    50                  55                  60                  


Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe 
65                  70                  75                  80  


Thr Asn Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg 
                85                  90                  95      


Gln Ile Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys 
            100                 105                 110         


Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn 
        115                 120                 125             


Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr Arg Tyr Arg Leu Phe 
    130                 135                 140                 


Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile 
145                 150                 155                 160 


Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys 
                165                 170                 175     


Tyr Phe Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly 
            180                 185                 190         


Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala 
        195                 200                 205             


Pro Ala Thr Val Cys Gly Pro Gly Ser Gly Gly Gly Gly Glu Ser Gln 
    210                 215                 220                 


Val Arg Gln Gln Phe Ser Lys Asp Ile Glu Lys Leu Leu Asn Glu Gln 
225                 230                 235                 240 


Val Asn Lys Glu Met Gln Ser Ser Asn Leu Tyr Met Ser Met Ser Ser 
                245                 250                 255     


Trp Cys Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp 
            260                 265                 270         


His Ala Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe Leu 
        275                 280                 285             


Asn Glu Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro Glu 
    290                 295                 300                 


His Lys Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu His 
305                 310                 315                 320 


Glu Gln His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala Ile 
                325                 330                 335     


Lys Ser Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala 
            340                 345                 350         


Glu Gln His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys Ile 
        355                 360                 365             


Glu Leu Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr 
    370                 375                 380                 


Val Lys Gly Ile Ala Lys Ser Arg Lys Ser Gly Ser 
385                 390                 395     


<210> 55
<211> 396
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 55
His His His His His His His His Gly Pro Leu Glu Val Leu Phe Gln 
1               5                   10                  15      


Gly Pro Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala 
            20                  25                  30          


Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn 
        35                  40                  45              


Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr 
    50                  55                  60                  


Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe 
65                  70                  75                  80  


Thr Asn Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg 
                85                  90                  95      


Gln Ile Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys 
            100                 105                 110         


Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn 
        115                 120                 125             


Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe 
    130                 135                 140                 


Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile 
145                 150                 155                 160 


Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys 
                165                 170                 175     


Tyr Phe Pro Arg Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly 
            180                 185                 190         


Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala 
        195                 200                 205             


Pro Ala Thr Val Cys Gly Pro Gly Ser Gly Gly Gly Gly Glu Ser Gln 
    210                 215                 220                 


Val Arg Gln Gln Phe Ser Lys Asp Ile Glu Lys Leu Leu Asn Glu Gln 
225                 230                 235                 240 


Val Asn Lys Glu Met Gln Ser Ser Asn Leu Tyr Met Ser Met Ser Ser 
                245                 250                 255     


Trp Cys Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp 
            260                 265                 270         


His Ala Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe Leu 
        275                 280                 285             


Asn Glu Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro Glu 
    290                 295                 300                 


His Lys Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu His 
305                 310                 315                 320 


Glu Gln His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala Ile 
                325                 330                 335     


Lys Ser Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala 
            340                 345                 350         


Glu Gln His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys Ile 
        355                 360                 365             


Glu Leu Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr 
    370                 375                 380                 


Val Lys Gly Ile Ala Lys Ser Arg Lys Ser Gly Ser 
385                 390                 395     


<210> 56
<211> 396
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 56
His His His His His His His His Gly Pro Leu Glu Val Leu Phe Gln 
1               5                   10                  15      


Gly Pro Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala 
            20                  25                  30          


Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn 
        35                  40                  45              


Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr 
    50                  55                  60                  


Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe 
65                  70                  75                  80  


Thr Asn Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg 
                85                  90                  95      


Gln Ile Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys 
            100                 105                 110         


Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn 
        115                 120                 125             


Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe 
    130                 135                 140                 


Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile 
145                 150                 155                 160 


Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys 
                165                 170                 175     


Tyr Arg Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly 
            180                 185                 190         


Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala 
        195                 200                 205             


Pro Ala Thr Val Cys Gly Pro Gly Ser Gly Gly Gly Gly Glu Ser Gln 
    210                 215                 220                 


Val Arg Gln Gln Phe Ser Lys Asp Ile Glu Lys Leu Leu Asn Glu Gln 
225                 230                 235                 240 


Val Asn Lys Glu Met Gln Ser Ser Asn Leu Tyr Met Ser Met Ser Ser 
                245                 250                 255     


Trp Cys Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp 
            260                 265                 270         


His Ala Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe Leu 
        275                 280                 285             


Asn Glu Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro Glu 
    290                 295                 300                 


His Lys Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu His 
305                 310                 315                 320 


Glu Gln His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala Ile 
                325                 330                 335     


Lys Ser Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala 
            340                 345                 350         


Glu Gln His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys Ile 
        355                 360                 365             


Glu Leu Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr 
    370                 375                 380                 


Val Lys Gly Ile Ala Lys Ser Arg Lys Ser Gly Ser 
385                 390                 395     


<210> 57
<211> 396
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 57
His His His His His His His His Gly Pro Leu Glu Val Leu Phe Gln 
1               5                   10                  15      


Gly Pro Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala 
            20                  25                  30          


Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn 
        35                  40                  45              


Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr 
    50                  55                  60                  


Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe 
65                  70                  75                  80  


Thr Asn Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg 
                85                  90                  95      


Gln Ile Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys 
            100                 105                 110         


Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn 
        115                 120                 125             


Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe 
    130                 135                 140                 


Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile 
145                 150                 155                 160 


Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys 
                165                 170                 175     


Tyr Ala Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly 
            180                 185                 190         


Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala 
        195                 200                 205             


Pro Ala Thr Val Cys Gly Pro Gly Ser Gly Gly Gly Gly Glu Ser Gln 
    210                 215                 220                 


Val Arg Gln Gln Phe Ser Lys Asp Ile Glu Lys Leu Leu Asn Glu Gln 
225                 230                 235                 240 


Val Asn Lys Glu Met Gln Ser Ser Asn Leu Tyr Met Ser Met Ser Ser 
                245                 250                 255     


Trp Cys Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp 
            260                 265                 270         


His Ala Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe Leu 
        275                 280                 285             


Asn Glu Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro Glu 
    290                 295                 300                 


His Lys Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu His 
305                 310                 315                 320 


Glu Gln His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala Ile 
                325                 330                 335     


Lys Ser Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala 
            340                 345                 350         


Glu Gln His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys Ile 
        355                 360                 365             


Glu Leu Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr 
    370                 375                 380                 


Val Lys Gly Ile Ala Lys Ser Arg Lys Ser Gly Ser 
385                 390                 395     


<210> 58
<211> 396
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 58
His His His His His His His His Gly Pro Leu Glu Val Leu Phe Gln 
1               5                   10                  15      


Gly Pro Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala 
            20                  25                  30          


Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn 
        35                  40                  45              


Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr 
    50                  55                  60                  


Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe 
65                  70                  75                  80  


Thr Asn Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg 
                85                  90                  95      


Gln Ile Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys 
            100                 105                 110         


Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn 
        115                 120                 125             


Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe 
    130                 135                 140                 


Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile 
145                 150                 155                 160 


Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys 
                165                 170                 175     


Tyr Phe Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly 
            180                 185                 190         


Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe Glu Asn Lys Ser Ala 
        195                 200                 205             


Pro Ala Thr Val Cys Gly Pro Gly Ser Gly Gly Gly Gly Glu Ser Gln 
    210                 215                 220                 


Val Arg Gln Gln Phe Ser Lys Asp Ile Glu Lys Leu Leu Asn Glu Gln 
225                 230                 235                 240 


Val Asn Lys Glu Met Gln Ser Ser Asn Leu Tyr Met Ser Met Ser Ser 
                245                 250                 255     


Trp Cys Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp 
            260                 265                 270         


His Ala Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe Leu 
        275                 280                 285             


Asn Glu Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro Glu 
    290                 295                 300                 


His Lys Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu His 
305                 310                 315                 320 


Glu Gln His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala Ile 
                325                 330                 335     


Lys Ser Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala 
            340                 345                 350         


Glu Gln His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys Ile 
        355                 360                 365             


Glu Leu Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr 
    370                 375                 380                 


Val Lys Gly Ile Ala Lys Ser Arg Lys Ser Gly Ser 
385                 390                 395     


<210> 59
<211> 396
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 59
His His His His His His His His Gly Pro Leu Glu Val Leu Phe Gln 
1               5                   10                  15      


Gly Pro Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala 
            20                  25                  30          


Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn 
        35                  40                  45              


Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr 
    50                  55                  60                  


Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe 
65                  70                  75                  80  


Thr Asn Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg 
                85                  90                  95      


Gln Ile Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys 
            100                 105                 110         


Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn 
        115                 120                 125             


Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe 
    130                 135                 140                 


Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile 
145                 150                 155                 160 


Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys 
                165                 170                 175     


Tyr Phe Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly 
            180                 185                 190         


Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Arg His Ala 
        195                 200                 205             


Pro Ala Thr Val Cys Gly Pro Gly Ser Gly Gly Gly Gly Glu Ser Gln 
    210                 215                 220                 


Val Arg Gln Gln Phe Ser Lys Asp Ile Glu Lys Leu Leu Asn Glu Gln 
225                 230                 235                 240 


Val Asn Lys Glu Met Gln Ser Ser Asn Leu Tyr Met Ser Met Ser Ser 
                245                 250                 255     


Trp Cys Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp 
            260                 265                 270         


His Ala Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe Leu 
        275                 280                 285             


Asn Glu Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro Glu 
    290                 295                 300                 


His Lys Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu His 
305                 310                 315                 320 


Glu Gln His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala Ile 
                325                 330                 335     


Lys Ser Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala 
            340                 345                 350         


Glu Gln His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys Ile 
        355                 360                 365             


Glu Leu Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr 
    370                 375                 380                 


Val Lys Gly Ile Ala Lys Ser Arg Lys Ser Gly Ser 
385                 390                 395     


<210> 60
<211> 396
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 60
His His His His His His His His Gly Pro Leu Glu Val Leu Phe Gln 
1               5                   10                  15      


Gly Pro Asn Ile Thr Asn Asn Cys Pro Phe Gly Glu Val Phe Asn Ala 
            20                  25                  30          


Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn 
        35                  40                  45              


Cys Val Ala Asp Tyr Ser Thr Leu Tyr Asn Ser Ala Ser Phe Ser Thr 
    50                  55                  60                  


Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe 
65                  70                  75                  80  


Thr Asn Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg 
                85                  90                  95      


Gln Ile Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys 
            100                 105                 110         


Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn 
        115                 120                 125             


Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe 
    130                 135                 140                 


Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile 
145                 150                 155                 160 


Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys 
                165                 170                 175     


Tyr Phe Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly 
            180                 185                 190         


Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala 
        195                 200                 205             


Pro Ala Thr Val Cys Gly Pro Gly Ser Gly Gly Gly Gly Glu Ser Gln 
    210                 215                 220                 


Val Arg Gln Gln Phe Ser Lys Asp Ile Glu Lys Leu Leu Asn Glu Gln 
225                 230                 235                 240 


Val Asn Lys Glu Met Gln Ser Ser Asn Leu Tyr Met Ser Met Ser Ser 
                245                 250                 255     


Trp Cys Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp 
            260                 265                 270         


His Ala Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe Leu 
        275                 280                 285             


Asn Glu Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro Glu 
    290                 295                 300                 


His Lys Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu His 
305                 310                 315                 320 


Glu Gln His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala Ile 
                325                 330                 335     


Lys Ser Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala 
            340                 345                 350         


Glu Gln His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys Ile 
        355                 360                 365             


Glu Leu Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr 
    370                 375                 380                 


Val Lys Gly Ile Ala Lys Ser Arg Lys Ser Gly Ser 
385                 390                 395     


<210> 61
<211> 396
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 61
His His His His His His His His Gly Pro Leu Glu Val Leu Phe Gln 
1               5                   10                  15      


Gly Pro Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala 
            20                  25                  30          


Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn 
        35                  40                  45              


Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr 
    50                  55                  60                  


Phe Lys Cys Tyr Gly Val Ser Pro Asn Lys Thr Asn Asp Leu Cys Phe 
65                  70                  75                  80  


Thr Asn Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg 
                85                  90                  95      


Gln Ile Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys 
            100                 105                 110         


Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn 
        115                 120                 125             


Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe 
    130                 135                 140                 


Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile 
145                 150                 155                 160 


Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys 
                165                 170                 175     


Tyr Phe Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly 
            180                 185                 190         


Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala 
        195                 200                 205             


Pro Ala Thr Val Cys Gly Pro Gly Ser Gly Gly Gly Gly Glu Ser Gln 
    210                 215                 220                 


Val Arg Gln Gln Phe Ser Lys Asp Ile Glu Lys Leu Leu Asn Glu Gln 
225                 230                 235                 240 


Val Asn Lys Glu Met Gln Ser Ser Asn Leu Tyr Met Ser Met Ser Ser 
                245                 250                 255     


Trp Cys Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp 
            260                 265                 270         


His Ala Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe Leu 
        275                 280                 285             


Asn Glu Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro Glu 
    290                 295                 300                 


His Lys Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu His 
305                 310                 315                 320 


Glu Gln His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala Ile 
                325                 330                 335     


Lys Ser Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala 
            340                 345                 350         


Glu Gln His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys Ile 
        355                 360                 365             


Glu Leu Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr 
    370                 375                 380                 


Val Lys Gly Ile Ala Lys Ser Arg Lys Ser Gly Ser 
385                 390                 395     


<210> 62
<211> 396
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 62
His His His His His His His His Gly Pro Leu Glu Val Leu Phe Gln 
1               5                   10                  15      


Gly Pro Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala 
            20                  25                  30          


Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn 
        35                  40                  45              


Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr 
    50                  55                  60                  


Phe Lys Cys Tyr Gly Arg Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe 
65                  70                  75                  80  


Thr Asn Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg 
                85                  90                  95      


Gln Ile Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys 
            100                 105                 110         


Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn 
        115                 120                 125             


Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe 
    130                 135                 140                 


Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile 
145                 150                 155                 160 


Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys 
                165                 170                 175     


Tyr Phe Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly 
            180                 185                 190         


Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala 
        195                 200                 205             


Pro Ala Thr Val Cys Gly Pro Gly Ser Gly Gly Gly Gly Glu Ser Gln 
    210                 215                 220                 


Val Arg Gln Gln Phe Ser Lys Asp Ile Glu Lys Leu Leu Asn Glu Gln 
225                 230                 235                 240 


Val Asn Lys Glu Met Gln Ser Ser Asn Leu Tyr Met Ser Met Ser Ser 
                245                 250                 255     


Trp Cys Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp 
            260                 265                 270         


His Ala Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe Leu 
        275                 280                 285             


Asn Glu Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro Glu 
    290                 295                 300                 


His Lys Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu His 
305                 310                 315                 320 


Glu Gln His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala Ile 
                325                 330                 335     


Lys Ser Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala 
            340                 345                 350         


Glu Gln His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys Ile 
        355                 360                 365             


Glu Leu Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr 
    370                 375                 380                 


Val Lys Gly Ile Ala Lys Ser Arg Lys Ser Gly Ser 
385                 390                 395     


<210> 63
<211> 396
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 63
His His His His His His His His Gly Pro Leu Glu Val Leu Phe Gln 
1               5                   10                  15      


Gly Pro Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala 
            20                  25                  30          


Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn 
        35                  40                  45              


Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr 
    50                  55                  60                  


Arg Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe 
65                  70                  75                  80  


Thr Asn Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg 
                85                  90                  95      


Gln Ile Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys 
            100                 105                 110         


Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn 
        115                 120                 125             


Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe 
    130                 135                 140                 


Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile 
145                 150                 155                 160 


Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys 
                165                 170                 175     


Tyr Phe Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly 
            180                 185                 190         


Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala 
        195                 200                 205             


Pro Ala Thr Val Cys Gly Pro Gly Ser Gly Gly Gly Gly Glu Ser Gln 
    210                 215                 220                 


Val Arg Gln Gln Phe Ser Lys Asp Ile Glu Lys Leu Leu Asn Glu Gln 
225                 230                 235                 240 


Val Asn Lys Glu Met Gln Ser Ser Asn Leu Tyr Met Ser Met Ser Ser 
                245                 250                 255     


Trp Cys Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp 
            260                 265                 270         


His Ala Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe Leu 
        275                 280                 285             


Asn Glu Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro Glu 
    290                 295                 300                 


His Lys Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu His 
305                 310                 315                 320 


Glu Gln His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala Ile 
                325                 330                 335     


Lys Ser Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala 
            340                 345                 350         


Glu Gln His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys Ile 
        355                 360                 365             


Glu Leu Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr 
    370                 375                 380                 


Val Lys Gly Ile Ala Lys Ser Arg Lys Ser Gly Ser 
385                 390                 395     


<210> 64
<211> 469
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 64
Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser 
1               5                   10                  15      


Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val 
            20                  25                  30          


Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr 
        35                  40                  45              


Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe 
    50                  55                  60                  


Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr 
65                  70                  75                  80  


Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp 
                85                  90                  95      


Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val 
            100                 105                 110         


Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val 
        115                 120                 125             


Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val 
    130                 135                 140                 


Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe 
145                 150                 155                 160 


Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu 
                165                 170                 175     


Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His 
            180                 185                 190         


Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu 
        195                 200                 205             


Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln 
    210                 215                 220                 


Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser 
225                 230                 235                 240 


Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln 
                245                 250                 255     


Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp 
            260                 265                 270         


Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu 
        275                 280                 285             


Gly Ser Gly Gly Gly Gly Glu Ser Gln Val Arg Gln Gln Phe Ser Lys 
    290                 295                 300                 


Asp Ile Glu Lys Leu Leu Asn Glu Gln Val Asn Lys Glu Met Gln Ser 
305                 310                 315                 320 


Ser Asn Leu Tyr Met Ser Met Ser Ser Trp Cys Tyr Thr His Ser Leu 
                325                 330                 335     


Asp Gly Ala Gly Leu Phe Leu Phe Asp His Ala Ala Glu Glu Tyr Glu 
            340                 345                 350         


His Ala Lys Lys Leu Ile Ile Phe Leu Asn Glu Asn Asn Val Pro Val 
        355                 360                 365             


Gln Leu Thr Ser Ile Ser Ala Pro Glu His Lys Phe Glu Gly Leu Thr 
    370                 375                 380                 


Gln Ile Phe Gln Lys Ala Tyr Glu His Glu Gln His Ile Ser Glu Ser 
385                 390                 395                 400 


Ile Asn Asn Ile Val Asp His Ala Ile Lys Ser Lys Asp His Ala Thr 
                405                 410                 415     


Phe Asn Phe Leu Gln Trp Tyr Val Ala Glu Gln His Glu Glu Glu Val 
            420                 425                 430         


Leu Phe Lys Asp Ile Leu Asp Lys Ile Glu Leu Ile Gly Asn Glu Asn 
        435                 440                 445             


His Gly Leu Tyr Leu Ala Asp Gln Tyr Val Lys Gly Ile Ala Lys Ser 
    450                 455                 460                 


Arg Lys Ser Gly Ser 
465                 


<210> 65
<211> 491
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 65
His His His His His His His His Gly Pro Leu Glu Val Leu Phe Gln 
1               5                   10                  15      


Gly Pro Ser Ser Gln Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro 
            20                  25                  30          


Pro Ala Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys 
        35                  40                  45              


Val Phe Arg Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro 
    50                  55                  60                  


Phe Phe Ser Asn Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr 
65                  70                  75                  80  


Asn Gly Thr Lys Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly 
                85                  90                  95      


Val Tyr Phe Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile 
            100                 105                 110         


Phe Gly Thr Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn 
        115                 120                 125             


Asn Ala Thr Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn 
    130                 135                 140                 


Asp Pro Phe Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met 
145                 150                 155                 160 


Glu Ser Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu 
                165                 170                 175     


Tyr Val Ser Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn 
            180                 185                 190         


Phe Lys Asn Leu Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe 
        195                 200                 205             


Lys Ile Tyr Ser Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro 
    210                 215                 220                 


Gln Gly Phe Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile 
225                 230                 235                 240 


Asn Ile Thr Arg Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu 
                245                 250                 255     


Thr Pro Gly Asp Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr 
            260                 265                 270         


Tyr Val Gly Tyr Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu 
        275                 280                 285             


Asn Gly Thr Ile Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser 
    290                 295                 300                 


Glu Thr Lys Cys Thr Leu Gly Ser Gly Gly Gly Gly Glu Ser Gln Val 
305                 310                 315                 320 


Arg Gln Gln Phe Ser Lys Asp Ile Glu Lys Leu Leu Asn Glu Gln Val 
                325                 330                 335     


Asn Lys Glu Met Gln Ser Ser Asn Leu Tyr Met Ser Met Ser Ser Trp 
            340                 345                 350         


Cys Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp His 
        355                 360                 365             


Ala Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe Leu Asn 
    370                 375                 380                 


Glu Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro Glu His 
385                 390                 395                 400 


Lys Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu His Glu 
                405                 410                 415     


Gln His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala Ile Lys 
            420                 425                 430         


Ser Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala Glu 
        435                 440                 445             


Gln His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys Ile Glu 
    450                 455                 460                 


Leu Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr Val 
465                 470                 475                 480 


Lys Gly Ile Ala Lys Ser Arg Lys Ser Gly Ser 
                485                 490     


<210> 66
<211> 473
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 66
Ser Ser Gln Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala 
1               5                   10                  15      


Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe 
            20                  25                  30          


Arg Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe 
        35                  40                  45              


Ser Asn Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly 
    50                  55                  60                  


Thr Lys Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr 
65                  70                  75                  80  


Phe Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly 
                85                  90                  95      


Thr Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala 
            100                 105                 110         


Thr Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro 
        115                 120                 125             


Phe Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser 
    130                 135                 140                 


Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val 
145                 150                 155                 160 


Ser Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys 
                165                 170                 175     


Asn Leu Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile 
            180                 185                 190         


Tyr Ser Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly 
        195                 200                 205             


Phe Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile 
    210                 215                 220                 


Thr Arg Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro 
225                 230                 235                 240 


Gly Asp Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val 
                245                 250                 255     


Gly Tyr Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly 
            260                 265                 270         


Thr Ile Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr 
        275                 280                 285             


Lys Cys Thr Leu Gly Ser Gly Gly Gly Gly Glu Ser Gln Val Arg Gln 
    290                 295                 300                 


Gln Phe Ser Lys Asp Ile Glu Lys Leu Leu Asn Glu Gln Val Asn Lys 
305                 310                 315                 320 


Glu Met Gln Ser Ser Asn Leu Tyr Met Ser Met Ser Ser Trp Cys Tyr 
                325                 330                 335     


Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp His Ala Ala 
            340                 345                 350         


Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe Leu Asn Glu Asn 
        355                 360                 365             


Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro Glu His Lys Phe 
    370                 375                 380                 


Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu His Glu Gln His 
385                 390                 395                 400 


Ile Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala Ile Lys Ser Lys 
                405                 410                 415     


Asp His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala Glu Gln His 
            420                 425                 430         


Glu Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys Ile Glu Leu Ile 
        435                 440                 445             


Gly Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr Val Lys Gly 
    450                 455                 460                 


Ile Ala Lys Ser Arg Lys Ser Gly Ser 
465                 470             


<210> 67
<211> 866
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 67
His His His His His His His His Gly Pro Leu Glu Val Leu Phe Gln 
1               5                   10                  15      


Gly Pro Ser Ser Gln Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro 
            20                  25                  30          


Pro Ala Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys 
        35                  40                  45              


Val Phe Arg Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro 
    50                  55                  60                  


Phe Phe Ser Asn Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr 
65                  70                  75                  80  


Asn Gly Thr Lys Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly 
                85                  90                  95      


Val Tyr Phe Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile 
            100                 105                 110         


Phe Gly Thr Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn 
        115                 120                 125             


Asn Ala Thr Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn 
    130                 135                 140                 


Asp Pro Phe Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met 
145                 150                 155                 160 


Glu Ser Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu 
                165                 170                 175     


Tyr Val Ser Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn 
            180                 185                 190         


Phe Lys Asn Leu Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe 
        195                 200                 205             


Lys Ile Tyr Ser Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro 
    210                 215                 220                 


Gln Gly Phe Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile 
225                 230                 235                 240 


Asn Ile Thr Arg Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu 
                245                 250                 255     


Thr Pro Gly Asp Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr 
            260                 265                 270         


Tyr Val Gly Tyr Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu 
        275                 280                 285             


Asn Gly Thr Ile Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser 
    290                 295                 300                 


Glu Thr Lys Cys Thr Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr 
305                 310                 315                 320 


Gln Thr Ser Asn Phe Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe 
                325                 330                 335     


Pro Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr 
            340                 345                 350         


Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys 
        355                 360                 365             


Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe 
    370                 375                 380                 


Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr 
385                 390                 395                 400 


Asn Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln 
                405                 410                 415     


Ile Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu 
            420                 425                 430         


Pro Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu 
        435                 440                 445             


Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg 
    450                 455                 460                 


Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr 
465                 470                 475                 480 


Gln Ala Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr 
                485                 490                 495     


Phe Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr 
            500                 505                 510         


Gln Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro 
        515                 520                 525             


Ala Thr Val Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys 
    530                 535                 540                 


Cys Val Asn Phe Asn Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr 
545                 550                 555                 560 


Glu Ser Asn Lys Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile 
                565                 570                 575     


Ala Asp Thr Thr Asp Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu 
            580                 585                 590         


Asp Ile Thr Pro Cys Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly 
        595                 600                 605             


Thr Asn Thr Ser Asn Gln Val Ala Val Leu Tyr Gln Asp Val Asn Cys 
    610                 615                 620                 


Thr Glu Val Pro Val Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp 
625                 630                 635                 640 


Arg Val Tyr Ser Thr Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys 
                645                 650                 655     


Leu Ile Gly Ala Glu His Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro 
            660                 665                 670         


Ile Gly Ala Gly Ile Cys Ala Ser Tyr Gln Thr Gln Thr Gly Ser Gly 
        675                 680                 685             


Gly Gly Gly Glu Ser Gln Val Arg Gln Gln Phe Ser Lys Asp Ile Glu 
    690                 695                 700                 


Lys Leu Leu Asn Glu Gln Val Asn Lys Glu Met Gln Ser Ser Asn Leu 
705                 710                 715                 720 


Tyr Met Ser Met Ser Ser Trp Cys Tyr Thr His Ser Leu Asp Gly Ala 
                725                 730                 735     


Gly Leu Phe Leu Phe Asp His Ala Ala Glu Glu Tyr Glu His Ala Lys 
            740                 745                 750         


Lys Leu Ile Ile Phe Leu Asn Glu Asn Asn Val Pro Val Gln Leu Thr 
        755                 760                 765             


Ser Ile Ser Ala Pro Glu His Lys Phe Glu Gly Leu Thr Gln Ile Phe 
    770                 775                 780                 


Gln Lys Ala Tyr Glu His Glu Gln His Ile Ser Glu Ser Ile Asn Asn 
785                 790                 795                 800 


Ile Val Asp His Ala Ile Lys Ser Lys Asp His Ala Thr Phe Asn Phe 
                805                 810                 815     


Leu Gln Trp Tyr Val Ala Glu Gln His Glu Glu Glu Val Leu Phe Lys 
            820                 825                 830         


Asp Ile Leu Asp Lys Ile Glu Leu Ile Gly Asn Glu Asn His Gly Leu 
        835                 840                 845             


Tyr Leu Ala Asp Gln Tyr Val Lys Gly Ile Ala Lys Ser Arg Lys Ser 
    850                 855                 860                 


Gly Ser 
865     


<210> 68
<211> 848
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 68
Ser Ser Gln Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala 
1               5                   10                  15      


Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe 
            20                  25                  30          


Arg Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe 
        35                  40                  45              


Ser Asn Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly 
    50                  55                  60                  


Thr Lys Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr 
65                  70                  75                  80  


Phe Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly 
                85                  90                  95      


Thr Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala 
            100                 105                 110         


Thr Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro 
        115                 120                 125             


Phe Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser 
    130                 135                 140                 


Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val 
145                 150                 155                 160 


Ser Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys 
                165                 170                 175     


Asn Leu Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile 
            180                 185                 190         


Tyr Ser Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly 
        195                 200                 205             


Phe Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile 
    210                 215                 220                 


Thr Arg Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro 
225                 230                 235                 240 


Gly Asp Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val 
                245                 250                 255     


Gly Tyr Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly 
            260                 265                 270         


Thr Ile Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr 
        275                 280                 285             


Lys Cys Thr Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr 
    290                 295                 300                 


Ser Asn Phe Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn 
305                 310                 315                 320 


Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe 
                325                 330                 335     


Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala 
            340                 345                 350         


Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys 
        355                 360                 365             


Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val 
    370                 375                 380                 


Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala 
385                 390                 395                 400 


Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp 
                405                 410                 415     


Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser 
            420                 425                 430         


Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser 
        435                 440                 445             


Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala 
    450                 455                 460                 


Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro 
465                 470                 475                 480 


Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro 
                485                 490                 495     


Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr 
            500                 505                 510         


Val Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val 
        515                 520                 525             


Asn Phe Asn Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser 
    530                 535                 540                 


Asn Lys Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp 
545                 550                 555                 560 


Thr Thr Asp Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile 
                565                 570                 575     


Thr Pro Cys Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn 
            580                 585                 590         


Thr Ser Asn Gln Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu 
        595                 600                 605             


Val Pro Val Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val 
    610                 615                 620                 


Tyr Ser Thr Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile 
625                 630                 635                 640 


Gly Ala Glu His Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly 
                645                 650                 655     


Ala Gly Ile Cys Ala Ser Tyr Gln Thr Gln Thr Gly Ser Gly Gly Gly 
            660                 665                 670         


Gly Glu Ser Gln Val Arg Gln Gln Phe Ser Lys Asp Ile Glu Lys Leu 
        675                 680                 685             


Leu Asn Glu Gln Val Asn Lys Glu Met Gln Ser Ser Asn Leu Tyr Met 
    690                 695                 700                 


Ser Met Ser Ser Trp Cys Tyr Thr His Ser Leu Asp Gly Ala Gly Leu 
705                 710                 715                 720 


Phe Leu Phe Asp His Ala Ala Glu Glu Tyr Glu His Ala Lys Lys Leu 
                725                 730                 735     


Ile Ile Phe Leu Asn Glu Asn Asn Val Pro Val Gln Leu Thr Ser Ile 
            740                 745                 750         


Ser Ala Pro Glu His Lys Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys 
        755                 760                 765             


Ala Tyr Glu His Glu Gln His Ile Ser Glu Ser Ile Asn Asn Ile Val 
    770                 775                 780                 


Asp His Ala Ile Lys Ser Lys Asp His Ala Thr Phe Asn Phe Leu Gln 
785                 790                 795                 800 


Trp Tyr Val Ala Glu Gln His Glu Glu Glu Val Leu Phe Lys Asp Ile 
                805                 810                 815     


Leu Asp Lys Ile Glu Leu Ile Gly Asn Glu Asn His Gly Leu Tyr Leu 
            820                 825                 830         


Ala Asp Gln Tyr Val Lys Gly Ile Ala Lys Ser Arg Lys Ser Gly Ser 
        835                 840                 845             


<210> 69
<211> 1275
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 69
Ser Ser Gln Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala 
1               5                   10                  15      


Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe 
            20                  25                  30          


Arg Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe 
        35                  40                  45              


Ser Asn Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly 
    50                  55                  60                  


Thr Lys Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr 
65                  70                  75                  80  


Phe Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly 
                85                  90                  95      


Thr Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala 
            100                 105                 110         


Thr Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro 
        115                 120                 125             


Phe Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser 
    130                 135                 140                 


Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val 
145                 150                 155                 160 


Ser Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys 
                165                 170                 175     


Asn Leu Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile 
            180                 185                 190         


Tyr Ser Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly 
        195                 200                 205             


Phe Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile 
    210                 215                 220                 


Thr Arg Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro 
225                 230                 235                 240 


Gly Asp Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val 
                245                 250                 255     


Gly Tyr Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly 
            260                 265                 270         


Thr Ile Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr 
        275                 280                 285             


Lys Cys Thr Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr 
    290                 295                 300                 


Ser Asn Phe Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn 
305                 310                 315                 320 


Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe 
                325                 330                 335     


Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala 
            340                 345                 350         


Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys 
        355                 360                 365             


Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val 
    370                 375                 380                 


Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala 
385                 390                 395                 400 


Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp 
                405                 410                 415     


Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser 
            420                 425                 430         


Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser 
        435                 440                 445             


Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala 
    450                 455                 460                 


Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro 
465                 470                 475                 480 


Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro 
                485                 490                 495     


Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr 
            500                 505                 510         


Val Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val 
        515                 520                 525             


Asn Phe Asn Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser 
    530                 535                 540                 


Asn Lys Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp 
545                 550                 555                 560 


Thr Thr Asp Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile 
                565                 570                 575     


Thr Pro Cys Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn 
            580                 585                 590         


Thr Ser Asn Gln Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu 
        595                 600                 605             


Val Pro Val Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val 
    610                 615                 620                 


Tyr Ser Thr Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile 
625                 630                 635                 640 


Gly Ala Glu His Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly 
                645                 650                 655     


Ala Gly Ile Cys Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro Gly Ser 
            660                 665                 670         


Ala Ser Ser Val Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu 
        675                 680                 685             


Gly Ala Glu Asn Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro 
    690                 695                 700                 


Thr Asn Phe Thr Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met 
705                 710                 715                 720 


Thr Lys Thr Ser Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr 
                725                 730                 735     


Glu Cys Ser Asn Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu 
            740                 745                 750         


Asn Arg Ala Leu Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln 
        755                 760                 765             


Glu Val Phe Ala Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys 
    770                 775                 780                 


Asp Phe Gly Gly Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys 
785                 790                 795                 800 


Pro Ser Lys Arg Ser Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr 
                805                 810                 815     


Leu Ala Asp Ala Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp 
            820                 825                 830         


Ile Ala Ala Arg Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr 
        835                 840                 845             


Val Leu Pro Pro Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser 
    850                 855                 860                 


Ala Leu Leu Ala Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly 
865                 870                 875                 880 


Ala Ala Leu Gln Ile Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn 
                885                 890                 895     


Gly Ile Gly Val Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile 
            900                 905                 910         


Ala Asn Gln Phe Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser 
        915                 920                 925             


Ser Thr Ala Ser Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn 
    930                 935                 940                 


Ala Gln Ala Leu Asn Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly 
945                 950                 955                 960 


Ala Ile Ser Ser Val Leu Asn Asp Ile Leu Ser Arg Leu Asp Pro Pro 
                965                 970                 975     


Glu Ala Glu Val Gln Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser 
            980                 985                 990         


Leu Gln Thr Tyr Val Thr Gln Gln  Leu Ile Arg Ala Ala  Glu Ile Arg 
        995                 1000                 1005             


Ala Ser  Ala Asn Leu Ala Ala  Thr Lys Met Ser Glu  Cys Val Leu 
    1010                 1015                 1020             


Gly Gln  Ser Lys Arg Val Asp  Phe Cys Gly Lys Gly  Tyr His Leu 
    1025                 1030                 1035             


Met Ser  Phe Pro Gln Ser Ala  Pro His Gly Val Val  Phe Leu His 
    1040                 1045                 1050             


Val Thr  Tyr Val Pro Ala Gln  Glu Lys Asn Phe Thr  Thr Ala Pro 
    1055                 1060                 1065             


Ala Ile  Cys His Asp Gly Lys  Ala His Phe Pro Arg  Glu Gly Val 
    1070                 1075                 1080             


Phe Val  Ser Asn Gly Thr His  Trp Phe Val Thr Gln  Arg Asn Phe 
    1085                 1090                 1095             


Tyr Glu  Pro Gln Ile Ile Thr  Thr Asp Asn Thr Phe  Val Ser Gly 
    1100                 1105                 1110             


Asn Cys  Asp Val Val Ile Gly  Ile Val Asn Asn Thr  Val Tyr Asp 
    1115                 1120                 1125             


Pro Leu  Gln Pro Glu Leu Asp  Ser Phe Lys Glu Glu  Leu Asp Lys 
    1130                 1135                 1140             


Tyr Phe  Lys Asn His Thr Ser  Pro Asp Val Asp Leu  Gly Asp Ile 
    1145                 1150                 1155             


Ser Gly  Ile Asn Ala Ser Val  Val Asn Ile Gln Lys  Glu Ile Asp 
    1160                 1165                 1170             


Arg Leu  Asn Glu Val Ala Lys  Asn Leu Asn Glu Ser  Leu Ile Asp 
    1175                 1180                 1185             


Leu Gln  Glu Leu Gly Lys Tyr  Glu Gln Gly Ser Gly  Tyr Ile Pro 
    1190                 1195                 1200             


Glu Ala  Pro Arg Asp Gly Gln  Ala Tyr Val Arg Lys  Asp Gly Glu 
    1205                 1210                 1215             


Trp Val  Leu Leu Ser Thr Phe  Leu Gly Leu Glu Val  Leu Phe Gln 
    1220                 1225                 1230             


Gly Pro  Ser Ala Trp Ser His  Pro Gln Phe Glu Lys  Gly Gly Gly 
    1235                 1240                 1245             


Ser Gly  Gly Gly Ser Gly Gly  Ser Ala Trp Ser His  Pro Gln Phe 
    1250                 1255                 1260             


Glu Lys  Gly Ser His His His  His His His His His  
    1265                 1270                 1275 


<210> 70
<211> 1291
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 70
Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser 
1               5                   10                  15      


Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val 
            20                  25                  30          


Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr 
        35                  40                  45              


Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe 
    50                  55                  60                  


Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr 
65                  70                  75                  80  


Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp 
                85                  90                  95      


Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val 
            100                 105                 110         


Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val 
        115                 120                 125             


Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val 
    130                 135                 140                 


Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe 
145                 150                 155                 160 


Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu 
                165                 170                 175     


Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His 
            180                 185                 190         


Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu 
        195                 200                 205             


Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln 
    210                 215                 220                 


Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser 
225                 230                 235                 240 


Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln 
                245                 250                 255     


Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp 
            260                 265                 270         


Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu 
        275                 280                 285             


Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg 
    290                 295                 300                 


Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu 
305                 310                 315                 320 


Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr 
                325                 330                 335     


Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val 
            340                 345                 350         


Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser 
        355                 360                 365             


Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser 
    370                 375                 380                 


Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr 
385                 390                 395                 400 


Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly 
                405                 410                 415     


Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly 
            420                 425                 430         


Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro 
        435                 440                 445             


Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro 
    450                 455                 460                 


Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr 
465                 470                 475                 480 


Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val 
                485                 490                 495     


Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro 
            500                 505                 510         


Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe 
        515                 520                 525             


Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe 
    530                 535                 540                 


Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala 
545                 550                 555                 560 


Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser 
                565                 570                 575     


Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln 
            580                 585                 590         


Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala 
        595                 600                 605             


Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly 
    610                 615                 620                 


Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His 
625                 630                 635                 640 


Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys 
                645                 650                 655     


Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro Gly Ser Ala Ser Ser Val 
            660                 665                 670         


Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn 
        675                 680                 685             


Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr 
    690                 695                 700                 


Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser 
705                 710                 715                 720 


Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn 
                725                 730                 735     


Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu 
            740                 745                 750         


Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala 
        755                 760                 765             


Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly 
    770                 775                 780                 


Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg 
785                 790                 795                 800 


Ser Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala 
                805                 810                 815     


Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg 
            820                 825                 830         


Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro 
        835                 840                 845             


Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala 
    850                 855                 860                 


Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln 
865                 870                 875                 880 


Ile Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val 
                885                 890                 895     


Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe 
            900                 905                 910         


Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser 
        915                 920                 925             


Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu 
    930                 935                 940                 


Asn Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser 
945                 950                 955                 960 


Val Leu Asn Asp Ile Leu Ser Arg Leu Asp Pro Pro Glu Ala Glu Val 
                965                 970                 975     


Gln Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser Leu Gln Thr Tyr 
            980                 985                 990         


Val Thr Gln Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
        995                 1000                 1005             


Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1010                 1015                 1020             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1025                 1030                 1035             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1040                 1045                 1050             


Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1055                 1060                 1065             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1070                 1075                 1080             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1085                 1090                 1095             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1100                 1105                 1110             


Val Ile  Gly Ile Val Asn Asn  Thr Val Gly Ser Gly  Gly Asp Ile 
    1115                 1120                 1125             


Ile Lys  Leu Leu Asn Glu Gln  Val Asn Lys Glu Met  Gln Ser Ser 
    1130                 1135                 1140             


Asn Leu  Tyr Met Ser Met Ser  Ser Trp Cys Tyr Thr  His Ser Leu 
    1145                 1150                 1155             


Asp Gly  Ala Gly Leu Phe Leu  Phe Asp His Ala Ala  Glu Glu Tyr 
    1160                 1165                 1170             


Glu His  Ala Lys Lys Leu Ile  Ile Phe Leu Asn Glu  Asn Asn Val 
    1175                 1180                 1185             


Pro Val  Gln Leu Thr Ser Ile  Ser Ala Pro Glu His  Lys Phe Glu 
    1190                 1195                 1200             


Gly Leu  Thr Gln Ile Phe Gln  Lys Ala Tyr Glu His  Glu Gln His 
    1205                 1210                 1215             


Ile Ser  Glu Ser Ile Asn Asn  Ile Val Asp His Ala  Ile Lys Ser 
    1220                 1225                 1230             


Lys Asp  His Ala Thr Phe Asn  Phe Leu Gln Trp Tyr  Val Ala Glu 
    1235                 1240                 1245             


Gln His  Glu Glu Glu Val Leu  Phe Lys Asp Ile Leu  Asp Lys Ile 
    1250                 1255                 1260             


Glu Leu  Ile Gly Asn Glu Asn  His Gly Leu Tyr Leu  Ala Asp Gln 
    1265                 1270                 1275             


Tyr Val  Lys Gly Ile Ala Lys  Ser Arg Lys Ser Gly  Ser 
    1280                 1285                 1290     


<210> 71
<211> 1293
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 71
Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser 
1               5                   10                  15      


Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val 
            20                  25                  30          


Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr 
        35                  40                  45              


Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe 
    50                  55                  60                  


Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr 
65                  70                  75                  80  


Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp 
                85                  90                  95      


Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val 
            100                 105                 110         


Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val 
        115                 120                 125             


Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val 
    130                 135                 140                 


Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe 
145                 150                 155                 160 


Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu 
                165                 170                 175     


Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His 
            180                 185                 190         


Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu 
        195                 200                 205             


Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln 
    210                 215                 220                 


Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser 
225                 230                 235                 240 


Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln 
                245                 250                 255     


Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp 
            260                 265                 270         


Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu 
        275                 280                 285             


Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg 
    290                 295                 300                 


Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu 
305                 310                 315                 320 


Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr 
                325                 330                 335     


Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val 
            340                 345                 350         


Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser 
        355                 360                 365             


Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser 
    370                 375                 380                 


Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr 
385                 390                 395                 400 


Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly 
                405                 410                 415     


Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly 
            420                 425                 430         


Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro 
        435                 440                 445             


Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro 
    450                 455                 460                 


Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr 
465                 470                 475                 480 


Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val 
                485                 490                 495     


Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro 
            500                 505                 510         


Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe 
        515                 520                 525             


Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe 
    530                 535                 540                 


Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala 
545                 550                 555                 560 


Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser 
                565                 570                 575     


Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln 
            580                 585                 590         


Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala 
        595                 600                 605             


Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly 
    610                 615                 620                 


Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His 
625                 630                 635                 640 


Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys 
                645                 650                 655     


Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro Gly Ser Ala Ser Ser Val 
            660                 665                 670         


Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn 
        675                 680                 685             


Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr 
    690                 695                 700                 


Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser 
705                 710                 715                 720 


Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn 
                725                 730                 735     


Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu 
            740                 745                 750         


Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala 
        755                 760                 765             


Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly 
    770                 775                 780                 


Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg 
785                 790                 795                 800 


Ser Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala 
                805                 810                 815     


Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg 
            820                 825                 830         


Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro 
        835                 840                 845             


Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala 
    850                 855                 860                 


Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln 
865                 870                 875                 880 


Ile Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val 
                885                 890                 895     


Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe 
            900                 905                 910         


Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser 
        915                 920                 925             


Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu 
    930                 935                 940                 


Asn Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser 
945                 950                 955                 960 


Val Leu Asn Asp Ile Leu Ser Arg Leu Asp Pro Pro Glu Ala Glu Val 
                965                 970                 975     


Gln Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser Leu Gln Thr Tyr 
            980                 985                 990         


Val Thr Gln Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
        995                 1000                 1005             


Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1010                 1015                 1020             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1025                 1030                 1035             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1040                 1045                 1050             


Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1055                 1060                 1065             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1070                 1075                 1080             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1085                 1090                 1095             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1100                 1105                 1110             


Val Ile  Gly Ile Val Asn Asn  Thr Val Gly Ser Gly  Gly Ser Gly 
    1115                 1120                 1125             


Asp Ile  Ile Lys Leu Leu Asn  Glu Gln Val Asn Lys  Glu Met Gln 
    1130                 1135                 1140             


Ser Ser  Asn Leu Tyr Met Ser  Met Ser Ser Trp Cys  Tyr Thr His 
    1145                 1150                 1155             


Ser Leu  Asp Gly Ala Gly Leu  Phe Leu Phe Asp His  Ala Ala Glu 
    1160                 1165                 1170             


Glu Tyr  Glu His Ala Lys Lys  Leu Ile Ile Phe Leu  Asn Glu Asn 
    1175                 1180                 1185             


Asn Val  Pro Val Gln Leu Thr  Ser Ile Ser Ala Pro  Glu His Lys 
    1190                 1195                 1200             


Phe Glu  Gly Leu Thr Gln Ile  Phe Gln Lys Ala Tyr  Glu His Glu 
    1205                 1210                 1215             


Gln His  Ile Ser Glu Ser Ile  Asn Asn Ile Val Asp  His Ala Ile 
    1220                 1225                 1230             


Lys Ser  Lys Asp His Ala Thr  Phe Asn Phe Leu Gln  Trp Tyr Val 
    1235                 1240                 1245             


Ala Glu  Gln His Glu Glu Glu  Val Leu Phe Lys Asp  Ile Leu Asp 
    1250                 1255                 1260             


Lys Ile  Glu Leu Ile Gly Asn  Glu Asn His Gly Leu  Tyr Leu Ala 
    1265                 1270                 1275             


Asp Gln  Tyr Val Lys Gly Ile  Ala Lys Ser Arg Lys  Ser Gly Ser 
    1280                 1285                 1290             


<210> 72
<211> 1364
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 72
Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser 
1               5                   10                  15      


Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val 
            20                  25                  30          


Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr 
        35                  40                  45              


Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe 
    50                  55                  60                  


Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr 
65                  70                  75                  80  


Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp 
                85                  90                  95      


Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val 
            100                 105                 110         


Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val 
        115                 120                 125             


Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val 
    130                 135                 140                 


Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe 
145                 150                 155                 160 


Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu 
                165                 170                 175     


Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His 
            180                 185                 190         


Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu 
        195                 200                 205             


Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln 
    210                 215                 220                 


Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser 
225                 230                 235                 240 


Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln 
                245                 250                 255     


Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp 
            260                 265                 270         


Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu 
        275                 280                 285             


Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg 
    290                 295                 300                 


Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu 
305                 310                 315                 320 


Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr 
                325                 330                 335     


Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val 
            340                 345                 350         


Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser 
        355                 360                 365             


Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser 
    370                 375                 380                 


Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr 
385                 390                 395                 400 


Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly 
                405                 410                 415     


Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly 
            420                 425                 430         


Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro 
        435                 440                 445             


Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro 
    450                 455                 460                 


Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr 
465                 470                 475                 480 


Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val 
                485                 490                 495     


Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro 
            500                 505                 510         


Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe 
        515                 520                 525             


Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe 
    530                 535                 540                 


Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala 
545                 550                 555                 560 


Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser 
                565                 570                 575     


Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln 
            580                 585                 590         


Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala 
        595                 600                 605             


Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly 
    610                 615                 620                 


Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His 
625                 630                 635                 640 


Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys 
                645                 650                 655     


Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro Gly Ser Ala Ser Ser Val 
            660                 665                 670         


Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn 
        675                 680                 685             


Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr 
    690                 695                 700                 


Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser 
705                 710                 715                 720 


Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn 
                725                 730                 735     


Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu 
            740                 745                 750         


Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala 
        755                 760                 765             


Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly 
    770                 775                 780                 


Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg 
785                 790                 795                 800 


Ser Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala 
                805                 810                 815     


Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg 
            820                 825                 830         


Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro 
        835                 840                 845             


Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala 
    850                 855                 860                 


Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln 
865                 870                 875                 880 


Ile Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val 
                885                 890                 895     


Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe 
            900                 905                 910         


Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser 
        915                 920                 925             


Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu 
    930                 935                 940                 


Asn Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser 
945                 950                 955                 960 


Val Leu Asn Asp Ile Leu Ser Arg Leu Asp Pro Pro Glu Ala Glu Val 
                965                 970                 975     


Gln Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser Leu Gln Thr Tyr 
            980                 985                 990         


Val Thr Gln Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
        995                 1000                 1005             


Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1010                 1015                 1020             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1025                 1030                 1035             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1040                 1045                 1050             


Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1055                 1060                 1065             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1070                 1075                 1080             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1085                 1090                 1095             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1100                 1105                 1110             


Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro 
    1115                 1120                 1125             


Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Tyr  Phe Lys Asn 
    1130                 1135                 1140             


His Thr  Ser Pro Asp Val Asp  Leu Gly Asp Ile Ser  Gly Ile Asn 
    1145                 1150                 1155             


Ala Ser  Val Val Asn Ile Gln  Lys Glu Ile Asp Arg  Leu Asn Glu 
    1160                 1165                 1170             


Val Ala  Lys Asn Leu Asn Glu  Ser Leu Ile Asp Leu  Gln Glu Leu 
    1175                 1180                 1185             


Gly Lys  Tyr Glu Gln Gly Ser  Gly Gly Ser Gly Asp  Ile Ile Lys 
    1190                 1195                 1200             


Leu Leu  Asn Glu Gln Val Asn  Lys Glu Met Gln Ser  Ser Asn Leu 
    1205                 1210                 1215             


Tyr Met  Ser Met Ser Ser Trp  Cys Tyr Thr His Ser  Leu Asp Gly 
    1220                 1225                 1230             


Ala Gly  Leu Phe Leu Phe Asp  His Ala Ala Glu Glu  Tyr Glu His 
    1235                 1240                 1245             


Ala Lys  Lys Leu Ile Ile Phe  Leu Asn Glu Asn Asn  Val Pro Val 
    1250                 1255                 1260             


Gln Leu  Thr Ser Ile Ser Ala  Pro Glu His Lys Phe  Glu Gly Leu 
    1265                 1270                 1275             


Thr Gln  Ile Phe Gln Lys Ala  Tyr Glu His Glu Gln  His Ile Ser 
    1280                 1285                 1290             


Glu Ser  Ile Asn Asn Ile Val  Asp His Ala Ile Lys  Ser Lys Asp 
    1295                 1300                 1305             


His Ala  Thr Phe Asn Phe Leu  Gln Trp Tyr Val Ala  Glu Gln His 
    1310                 1315                 1320             


Glu Glu  Glu Val Leu Phe Lys  Asp Ile Leu Asp Lys  Ile Glu Leu 
    1325                 1330                 1335             


Ile Gly  Asn Glu Asn His Gly  Leu Tyr Leu Ala Asp  Gln Tyr Val 
    1340                 1345                 1350             


Lys Gly  Ile Ala Lys Ser Arg  Lys Ser Gly Ser 
    1355                 1360                 


<210> 73
<211> 1400
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 73
Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser 
1               5                   10                  15      


Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val 
            20                  25                  30          


Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr 
        35                  40                  45              


Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe 
    50                  55                  60                  


Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr 
65                  70                  75                  80  


Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp 
                85                  90                  95      


Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val 
            100                 105                 110         


Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val 
        115                 120                 125             


Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val 
    130                 135                 140                 


Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe 
145                 150                 155                 160 


Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu 
                165                 170                 175     


Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His 
            180                 185                 190         


Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu 
        195                 200                 205             


Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln 
    210                 215                 220                 


Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser 
225                 230                 235                 240 


Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln 
                245                 250                 255     


Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp 
            260                 265                 270         


Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu 
        275                 280                 285             


Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg 
    290                 295                 300                 


Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu 
305                 310                 315                 320 


Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr 
                325                 330                 335     


Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val 
            340                 345                 350         


Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser 
        355                 360                 365             


Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser 
    370                 375                 380                 


Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr 
385                 390                 395                 400 


Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly 
                405                 410                 415     


Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly 
            420                 425                 430         


Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro 
        435                 440                 445             


Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro 
    450                 455                 460                 


Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr 
465                 470                 475                 480 


Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val 
                485                 490                 495     


Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro 
            500                 505                 510         


Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe 
        515                 520                 525             


Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe 
    530                 535                 540                 


Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala 
545                 550                 555                 560 


Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser 
                565                 570                 575     


Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln 
            580                 585                 590         


Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala 
        595                 600                 605             


Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly 
    610                 615                 620                 


Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His 
625                 630                 635                 640 


Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys 
                645                 650                 655     


Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro Gly Ser Ala Ser Ser Val 
            660                 665                 670         


Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn 
        675                 680                 685             


Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr 
    690                 695                 700                 


Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser 
705                 710                 715                 720 


Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn 
                725                 730                 735     


Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu 
            740                 745                 750         


Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala 
        755                 760                 765             


Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly 
    770                 775                 780                 


Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg 
785                 790                 795                 800 


Ser Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala 
                805                 810                 815     


Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg 
            820                 825                 830         


Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro 
        835                 840                 845             


Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala 
    850                 855                 860                 


Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln 
865                 870                 875                 880 


Ile Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val 
                885                 890                 895     


Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe 
            900                 905                 910         


Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser 
        915                 920                 925             


Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu 
    930                 935                 940                 


Asn Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser 
945                 950                 955                 960 


Val Leu Asn Asp Ile Leu Ser Arg Leu Asp Pro Pro Glu Ala Glu Val 
                965                 970                 975     


Gln Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser Leu Gln Thr Tyr 
            980                 985                 990         


Val Thr Gln Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
        995                 1000                 1005             


Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1010                 1015                 1020             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1025                 1030                 1035             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1040                 1045                 1050             


Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1055                 1060                 1065             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1070                 1075                 1080             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1085                 1090                 1095             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1100                 1105                 1110             


Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro 
    1115                 1120                 1125             


Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Tyr  Phe Lys Asn 
    1130                 1135                 1140             


His Thr  Ser Pro Asp Val Asp  Leu Gly Asp Ile Ser  Gly Ile Asn 
    1145                 1150                 1155             


Ala Ser  Val Val Asn Ile Gln  Lys Glu Ile Asp Arg  Leu Asn Glu 
    1160                 1165                 1170             


Val Ala  Lys Asn Leu Asn Glu  Ser Leu Ile Asp Leu  Gln Glu Leu 
    1175                 1180                 1185             


Gly Lys  Tyr Glu Gln Gly Ser  Gly Gly Glu Met Lys  Gln Ile Glu 
    1190                 1195                 1200             


Asp Lys  Ile Glu Glu Ile Leu  Ser Lys Ile Tyr His  Ile Glu Asn 
    1205                 1210                 1215             


Glu Ile  Ala Arg Ile Lys Lys  Leu Ile Gly Arg Gly  Ser Gly Gly 
    1220                 1225                 1230             


Ser Gly  Asp Ile Ile Lys Leu  Leu Asn Glu Gln Val  Asn Lys Glu 
    1235                 1240                 1245             


Met Gln  Ser Ser Asn Leu Tyr  Met Ser Met Ser Ser  Trp Cys Tyr 
    1250                 1255                 1260             


Thr His  Ser Leu Asp Gly Ala  Gly Leu Phe Leu Phe  Asp His Ala 
    1265                 1270                 1275             


Ala Glu  Glu Tyr Glu His Ala  Lys Lys Leu Ile Ile  Phe Leu Asn 
    1280                 1285                 1290             


Glu Asn  Asn Val Pro Val Gln  Leu Thr Ser Ile Ser  Ala Pro Glu 
    1295                 1300                 1305             


His Lys  Phe Glu Gly Leu Thr  Gln Ile Phe Gln Lys  Ala Tyr Glu 
    1310                 1315                 1320             


His Glu  Gln His Ile Ser Glu  Ser Ile Asn Asn Ile  Val Asp His 
    1325                 1330                 1335             


Ala Ile  Lys Ser Lys Asp His  Ala Thr Phe Asn Phe  Leu Gln Trp 
    1340                 1345                 1350             


Tyr Val  Ala Glu Gln His Glu  Glu Glu Val Leu Phe  Lys Asp Ile 
    1355                 1360                 1365             


Leu Asp  Lys Ile Glu Leu Ile  Gly Asn Glu Asn His  Gly Leu Tyr 
    1370                 1375                 1380             


Leu Ala  Asp Gln Tyr Val Lys  Gly Ile Ala Lys Ser  Arg Lys Ser 
    1385                 1390                 1395             


Gly Ser  
    1400 


<210> 74
<211> 1310
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 74
Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser 
1               5                   10                  15      


Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val 
            20                  25                  30          


Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr 
        35                  40                  45              


Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe 
    50                  55                  60                  


Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr 
65                  70                  75                  80  


Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp 
                85                  90                  95      


Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val 
            100                 105                 110         


Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val 
        115                 120                 125             


Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val 
    130                 135                 140                 


Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe 
145                 150                 155                 160 


Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu 
                165                 170                 175     


Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His 
            180                 185                 190         


Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu 
        195                 200                 205             


Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln 
    210                 215                 220                 


Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser 
225                 230                 235                 240 


Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln 
                245                 250                 255     


Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp 
            260                 265                 270         


Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu 
        275                 280                 285             


Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg 
    290                 295                 300                 


Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu 
305                 310                 315                 320 


Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr 
                325                 330                 335     


Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val 
            340                 345                 350         


Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser 
        355                 360                 365             


Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser 
    370                 375                 380                 


Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr 
385                 390                 395                 400 


Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly 
                405                 410                 415     


Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly 
            420                 425                 430         


Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro 
        435                 440                 445             


Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro 
    450                 455                 460                 


Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr 
465                 470                 475                 480 


Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val 
                485                 490                 495     


Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro 
            500                 505                 510         


Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe 
        515                 520                 525             


Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe 
    530                 535                 540                 


Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala 
545                 550                 555                 560 


Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser 
                565                 570                 575     


Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln 
            580                 585                 590         


Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala 
        595                 600                 605             


Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly 
    610                 615                 620                 


Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His 
625                 630                 635                 640 


Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys 
                645                 650                 655     


Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro Gly Ser Ala Ser Ser Val 
            660                 665                 670         


Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn 
        675                 680                 685             


Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr 
    690                 695                 700                 


Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser 
705                 710                 715                 720 


Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn 
                725                 730                 735     


Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu 
            740                 745                 750         


Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala 
        755                 760                 765             


Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly 
    770                 775                 780                 


Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg 
785                 790                 795                 800 


Ser Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala 
                805                 810                 815     


Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg 
            820                 825                 830         


Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro 
        835                 840                 845             


Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala 
    850                 855                 860                 


Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln 
865                 870                 875                 880 


Ile Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val 
                885                 890                 895     


Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe 
            900                 905                 910         


Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser 
        915                 920                 925             


Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu 
    930                 935                 940                 


Asn Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser 
945                 950                 955                 960 


Val Leu Asn Asp Ile Leu Ser Arg Leu Asp Pro Pro Glu Ala Glu Val 
                965                 970                 975     


Gln Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser Leu Gln Thr Tyr 
            980                 985                 990         


Val Thr Gln Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
        995                 1000                 1005             


Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1010                 1015                 1020             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1025                 1030                 1035             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1040                 1045                 1050             


Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1055                 1060                 1065             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1070                 1075                 1080             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1085                 1090                 1095             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1100                 1105                 1110             


Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro 
    1115                 1120                 1125             


Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Gly  Ser Gly Gly 
    1130                 1135                 1140             


Ser Gly  Asp Ile Ile Lys Leu  Leu Asn Glu Gln Val  Asn Lys Glu 
    1145                 1150                 1155             


Met Gln  Ser Ser Asn Leu Tyr  Met Ser Met Ser Ser  Trp Cys Tyr 
    1160                 1165                 1170             


Thr His  Ser Leu Asp Gly Ala  Gly Leu Phe Leu Phe  Asp His Ala 
    1175                 1180                 1185             


Ala Glu  Glu Tyr Glu His Ala  Lys Lys Leu Ile Ile  Phe Leu Asn 
    1190                 1195                 1200             


Glu Asn  Asn Val Pro Val Gln  Leu Thr Ser Ile Ser  Ala Pro Glu 
    1205                 1210                 1215             


His Lys  Phe Glu Gly Leu Thr  Gln Ile Phe Gln Lys  Ala Tyr Glu 
    1220                 1225                 1230             


His Glu  Gln His Ile Ser Glu  Ser Ile Asn Asn Ile  Val Asp His 
    1235                 1240                 1245             


Ala Ile  Lys Ser Lys Asp His  Ala Thr Phe Asn Phe  Leu Gln Trp 
    1250                 1255                 1260             


Tyr Val  Ala Glu Gln His Glu  Glu Glu Val Leu Phe  Lys Asp Ile 
    1265                 1270                 1275             


Leu Asp  Lys Ile Glu Leu Ile  Gly Asn Glu Asn His  Gly Leu Tyr 
    1280                 1285                 1290             


Leu Ala  Asp Gln Tyr Val Lys  Gly Ile Ala Lys Ser  Arg Lys Ser 
    1295                 1300                 1305             


Gly Ser  
    1310 


<210> 75
<211> 1314
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 75
Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser 
1               5                   10                  15      


Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val 
            20                  25                  30          


Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr 
        35                  40                  45              


Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe 
    50                  55                  60                  


Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr 
65                  70                  75                  80  


Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp 
                85                  90                  95      


Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val 
            100                 105                 110         


Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val 
        115                 120                 125             


Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val 
    130                 135                 140                 


Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe 
145                 150                 155                 160 


Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu 
                165                 170                 175     


Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His 
            180                 185                 190         


Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu 
        195                 200                 205             


Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln 
    210                 215                 220                 


Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser 
225                 230                 235                 240 


Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln 
                245                 250                 255     


Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp 
            260                 265                 270         


Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu 
        275                 280                 285             


Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg 
    290                 295                 300                 


Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu 
305                 310                 315                 320 


Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr 
                325                 330                 335     


Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val 
            340                 345                 350         


Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser 
        355                 360                 365             


Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser 
    370                 375                 380                 


Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr 
385                 390                 395                 400 


Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly 
                405                 410                 415     


Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly 
            420                 425                 430         


Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro 
        435                 440                 445             


Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro 
    450                 455                 460                 


Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr 
465                 470                 475                 480 


Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val 
                485                 490                 495     


Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro 
            500                 505                 510         


Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe 
        515                 520                 525             


Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe 
    530                 535                 540                 


Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala 
545                 550                 555                 560 


Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser 
                565                 570                 575     


Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln 
            580                 585                 590         


Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala 
        595                 600                 605             


Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly 
    610                 615                 620                 


Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His 
625                 630                 635                 640 


Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys 
                645                 650                 655     


Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro Gly Ser Ala Ser Ser Val 
            660                 665                 670         


Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn 
        675                 680                 685             


Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr 
    690                 695                 700                 


Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser 
705                 710                 715                 720 


Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn 
                725                 730                 735     


Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu 
            740                 745                 750         


Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala 
        755                 760                 765             


Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly 
    770                 775                 780                 


Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg 
785                 790                 795                 800 


Ser Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala 
                805                 810                 815     


Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg 
            820                 825                 830         


Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro 
        835                 840                 845             


Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala 
    850                 855                 860                 


Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln 
865                 870                 875                 880 


Ile Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val 
                885                 890                 895     


Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe 
            900                 905                 910         


Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser 
        915                 920                 925             


Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu 
    930                 935                 940                 


Asn Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser 
945                 950                 955                 960 


Val Leu Asn Asp Ile Leu Ser Arg Leu Asp Pro Pro Glu Ala Glu Val 
                965                 970                 975     


Gln Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser Leu Gln Thr Tyr 
            980                 985                 990         


Val Thr Gln Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
        995                 1000                 1005             


Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1010                 1015                 1020             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1025                 1030                 1035             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1040                 1045                 1050             


Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1055                 1060                 1065             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1070                 1075                 1080             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1085                 1090                 1095             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1100                 1105                 1110             


Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Ser 
    1115                 1120                 1125             


Glu Leu  Asp Ser Ile Lys Glu  Glu Leu Asp Lys Ile  His Lys Asn 
    1130                 1135                 1140             


Gly Ser  Gly Gly Ser Gly Asp  Ile Ile Lys Leu Leu  Asn Glu Gln 
    1145                 1150                 1155             


Val Asn  Lys Glu Met Gln Ser  Ser Asn Leu Tyr Met  Ser Met Ser 
    1160                 1165                 1170             


Ser Trp  Cys Tyr Thr His Ser  Leu Asp Gly Ala Gly  Leu Phe Leu 
    1175                 1180                 1185             


Phe Asp  His Ala Ala Glu Glu  Tyr Glu His Ala Lys  Lys Leu Ile 
    1190                 1195                 1200             


Ile Phe  Leu Asn Glu Asn Asn  Val Pro Val Gln Leu  Thr Ser Ile 
    1205                 1210                 1215             


Ser Ala  Pro Glu His Lys Phe  Glu Gly Leu Thr Gln  Ile Phe Gln 
    1220                 1225                 1230             


Lys Ala  Tyr Glu His Glu Gln  His Ile Ser Glu Ser  Ile Asn Asn 
    1235                 1240                 1245             


Ile Val  Asp His Ala Ile Lys  Ser Lys Asp His Ala  Thr Phe Asn 
    1250                 1255                 1260             


Phe Leu  Gln Trp Tyr Val Ala  Glu Gln His Glu Glu  Glu Val Leu 
    1265                 1270                 1275             


Phe Lys  Asp Ile Leu Asp Lys  Ile Glu Leu Ile Gly  Asn Glu Asn 
    1280                 1285                 1290             


His Gly  Leu Tyr Leu Ala Asp  Gln Tyr Val Lys Gly  Ile Ala Lys 
    1295                 1300                 1305             


Ser Arg  Lys Ser Gly Ser 
    1310                 


<210> 76
<211> 1314
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 76
Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser 
1               5                   10                  15      


Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val 
            20                  25                  30          


Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr 
        35                  40                  45              


Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe 
    50                  55                  60                  


Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr 
65                  70                  75                  80  


Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp 
                85                  90                  95      


Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val 
            100                 105                 110         


Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val 
        115                 120                 125             


Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val 
    130                 135                 140                 


Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe 
145                 150                 155                 160 


Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu 
                165                 170                 175     


Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His 
            180                 185                 190         


Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu 
        195                 200                 205             


Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln 
    210                 215                 220                 


Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser 
225                 230                 235                 240 


Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln 
                245                 250                 255     


Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp 
            260                 265                 270         


Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu 
        275                 280                 285             


Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg 
    290                 295                 300                 


Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu 
305                 310                 315                 320 


Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr 
                325                 330                 335     


Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val 
            340                 345                 350         


Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser 
        355                 360                 365             


Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser 
    370                 375                 380                 


Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr 
385                 390                 395                 400 


Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly 
                405                 410                 415     


Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly 
            420                 425                 430         


Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro 
        435                 440                 445             


Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro 
    450                 455                 460                 


Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr 
465                 470                 475                 480 


Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val 
                485                 490                 495     


Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro 
            500                 505                 510         


Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe 
        515                 520                 525             


Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe 
    530                 535                 540                 


Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala 
545                 550                 555                 560 


Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser 
                565                 570                 575     


Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln 
            580                 585                 590         


Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala 
        595                 600                 605             


Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly 
    610                 615                 620                 


Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His 
625                 630                 635                 640 


Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys 
                645                 650                 655     


Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro Gly Ser Ala Ser Ser Val 
            660                 665                 670         


Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn 
        675                 680                 685             


Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr 
    690                 695                 700                 


Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser 
705                 710                 715                 720 


Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn 
                725                 730                 735     


Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu 
            740                 745                 750         


Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala 
        755                 760                 765             


Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly 
    770                 775                 780                 


Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg 
785                 790                 795                 800 


Ser Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala 
                805                 810                 815     


Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg 
            820                 825                 830         


Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro 
        835                 840                 845             


Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala 
    850                 855                 860                 


Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln 
865                 870                 875                 880 


Ile Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val 
                885                 890                 895     


Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe 
            900                 905                 910         


Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser 
        915                 920                 925             


Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu 
    930                 935                 940                 


Asn Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser 
945                 950                 955                 960 


Val Leu Asn Asp Ile Leu Ser Arg Leu Asp Pro Pro Glu Ala Glu Val 
                965                 970                 975     


Gln Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser Leu Gln Thr Tyr 
            980                 985                 990         


Val Thr Gln Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
        995                 1000                 1005             


Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1010                 1015                 1020             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1025                 1030                 1035             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1040                 1045                 1050             


Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1055                 1060                 1065             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1070                 1075                 1080             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1085                 1090                 1095             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1100                 1105                 1110             


Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Ser 
    1115                 1120                 1125             


Glu Ile  Asp Ser Ile Lys Glu  Glu Ile Asp Lys Ile  His Lys Asn 
    1130                 1135                 1140             


Gly Ser  Gly Gly Ser Gly Asp  Ile Ile Lys Leu Leu  Asn Glu Gln 
    1145                 1150                 1155             


Val Asn  Lys Glu Met Gln Ser  Ser Asn Leu Tyr Met  Ser Met Ser 
    1160                 1165                 1170             


Ser Trp  Cys Tyr Thr His Ser  Leu Asp Gly Ala Gly  Leu Phe Leu 
    1175                 1180                 1185             


Phe Asp  His Ala Ala Glu Glu  Tyr Glu His Ala Lys  Lys Leu Ile 
    1190                 1195                 1200             


Ile Phe  Leu Asn Glu Asn Asn  Val Pro Val Gln Leu  Thr Ser Ile 
    1205                 1210                 1215             


Ser Ala  Pro Glu His Lys Phe  Glu Gly Leu Thr Gln  Ile Phe Gln 
    1220                 1225                 1230             


Lys Ala  Tyr Glu His Glu Gln  His Ile Ser Glu Ser  Ile Asn Asn 
    1235                 1240                 1245             


Ile Val  Asp His Ala Ile Lys  Ser Lys Asp His Ala  Thr Phe Asn 
    1250                 1255                 1260             


Phe Leu  Gln Trp Tyr Val Ala  Glu Gln His Glu Glu  Glu Val Leu 
    1265                 1270                 1275             


Phe Lys  Asp Ile Leu Asp Lys  Ile Glu Leu Ile Gly  Asn Glu Asn 
    1280                 1285                 1290             


His Gly  Leu Tyr Leu Ala Asp  Gln Tyr Val Lys Gly  Ile Ala Lys 
    1295                 1300                 1305             


Ser Arg  Lys Ser Gly Ser 
    1310                 


<210> 77
<211> 1328
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 77
Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser 
1               5                   10                  15      


Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val 
            20                  25                  30          


Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr 
        35                  40                  45              


Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe 
    50                  55                  60                  


Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr 
65                  70                  75                  80  


Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp 
                85                  90                  95      


Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val 
            100                 105                 110         


Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val 
        115                 120                 125             


Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val 
    130                 135                 140                 


Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe 
145                 150                 155                 160 


Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu 
                165                 170                 175     


Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His 
            180                 185                 190         


Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu 
        195                 200                 205             


Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln 
    210                 215                 220                 


Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser 
225                 230                 235                 240 


Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln 
                245                 250                 255     


Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp 
            260                 265                 270         


Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu 
        275                 280                 285             


Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg 
    290                 295                 300                 


Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu 
305                 310                 315                 320 


Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr 
                325                 330                 335     


Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val 
            340                 345                 350         


Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser 
        355                 360                 365             


Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser 
    370                 375                 380                 


Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr 
385                 390                 395                 400 


Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly 
                405                 410                 415     


Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly 
            420                 425                 430         


Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro 
        435                 440                 445             


Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro 
    450                 455                 460                 


Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr 
465                 470                 475                 480 


Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val 
                485                 490                 495     


Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro 
            500                 505                 510         


Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe 
        515                 520                 525             


Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe 
    530                 535                 540                 


Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala 
545                 550                 555                 560 


Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser 
                565                 570                 575     


Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln 
            580                 585                 590         


Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala 
        595                 600                 605             


Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly 
    610                 615                 620                 


Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His 
625                 630                 635                 640 


Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys 
                645                 650                 655     


Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro Gly Ser Ala Ser Ser Val 
            660                 665                 670         


Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn 
        675                 680                 685             


Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr 
    690                 695                 700                 


Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser 
705                 710                 715                 720 


Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn 
                725                 730                 735     


Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu 
            740                 745                 750         


Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala 
        755                 760                 765             


Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly 
    770                 775                 780                 


Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg 
785                 790                 795                 800 


Ser Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala 
                805                 810                 815     


Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg 
            820                 825                 830         


Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro 
        835                 840                 845             


Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala 
    850                 855                 860                 


Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln 
865                 870                 875                 880 


Ile Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val 
                885                 890                 895     


Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe 
            900                 905                 910         


Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser 
        915                 920                 925             


Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu 
    930                 935                 940                 


Asn Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser 
945                 950                 955                 960 


Val Leu Asn Asp Ile Leu Ser Arg Leu Asp Pro Pro Glu Ala Glu Val 
                965                 970                 975     


Gln Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser Leu Gln Thr Tyr 
            980                 985                 990         


Val Thr Gln Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
        995                 1000                 1005             


Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1010                 1015                 1020             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1025                 1030                 1035             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1040                 1045                 1050             


Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1055                 1060                 1065             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1070                 1075                 1080             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1085                 1090                 1095             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1100                 1105                 1110             


Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Ser 
    1115                 1120                 1125             


Glu Leu  Asp Ser Ile Lys Glu  Glu Leu Asp Lys Ile  His Lys Asn 
    1130                 1135                 1140             


Leu Asp  Ser Ile Lys Glu Glu  Leu Asp Lys Ile His  Lys Asn Gly 
    1145                 1150                 1155             


Ser Gly  Gly Ser Gly Asp Ile  Ile Lys Leu Leu Asn  Glu Gln Val 
    1160                 1165                 1170             


Asn Lys  Glu Met Gln Ser Ser  Asn Leu Tyr Met Ser  Met Ser Ser 
    1175                 1180                 1185             


Trp Cys  Tyr Thr His Ser Leu  Asp Gly Ala Gly Leu  Phe Leu Phe 
    1190                 1195                 1200             


Asp His  Ala Ala Glu Glu Tyr  Glu His Ala Lys Lys  Leu Ile Ile 
    1205                 1210                 1215             


Phe Leu  Asn Glu Asn Asn Val  Pro Val Gln Leu Thr  Ser Ile Ser 
    1220                 1225                 1230             


Ala Pro  Glu His Lys Phe Glu  Gly Leu Thr Gln Ile  Phe Gln Lys 
    1235                 1240                 1245             


Ala Tyr  Glu His Glu Gln His  Ile Ser Glu Ser Ile  Asn Asn Ile 
    1250                 1255                 1260             


Val Asp  His Ala Ile Lys Ser  Lys Asp His Ala Thr  Phe Asn Phe 
    1265                 1270                 1275             


Leu Gln  Trp Tyr Val Ala Glu  Gln His Glu Glu Glu  Val Leu Phe 
    1280                 1285                 1290             


Lys Asp  Ile Leu Asp Lys Ile  Glu Leu Ile Gly Asn  Glu Asn His 
    1295                 1300                 1305             


Gly Leu  Tyr Leu Ala Asp Gln  Tyr Val Lys Gly Ile  Ala Lys Ser 
    1310                 1315                 1320             


Arg Lys  Ser Gly Ser 
    1325             


<210> 78
<211> 1328
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 78
Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser 
1               5                   10                  15      


Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val 
            20                  25                  30          


Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr 
        35                  40                  45              


Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe 
    50                  55                  60                  


Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr 
65                  70                  75                  80  


Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp 
                85                  90                  95      


Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val 
            100                 105                 110         


Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val 
        115                 120                 125             


Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val 
    130                 135                 140                 


Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe 
145                 150                 155                 160 


Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu 
                165                 170                 175     


Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His 
            180                 185                 190         


Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu 
        195                 200                 205             


Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln 
    210                 215                 220                 


Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser 
225                 230                 235                 240 


Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln 
                245                 250                 255     


Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp 
            260                 265                 270         


Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu 
        275                 280                 285             


Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg 
    290                 295                 300                 


Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu 
305                 310                 315                 320 


Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr 
                325                 330                 335     


Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val 
            340                 345                 350         


Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser 
        355                 360                 365             


Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser 
    370                 375                 380                 


Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr 
385                 390                 395                 400 


Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly 
                405                 410                 415     


Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly 
            420                 425                 430         


Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro 
        435                 440                 445             


Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro 
    450                 455                 460                 


Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr 
465                 470                 475                 480 


Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val 
                485                 490                 495     


Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro 
            500                 505                 510         


Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe 
        515                 520                 525             


Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe 
    530                 535                 540                 


Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala 
545                 550                 555                 560 


Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser 
                565                 570                 575     


Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln 
            580                 585                 590         


Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala 
        595                 600                 605             


Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly 
    610                 615                 620                 


Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His 
625                 630                 635                 640 


Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys 
                645                 650                 655     


Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro Gly Ser Ala Ser Ser Val 
            660                 665                 670         


Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn 
        675                 680                 685             


Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr 
    690                 695                 700                 


Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser 
705                 710                 715                 720 


Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn 
                725                 730                 735     


Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu 
            740                 745                 750         


Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala 
        755                 760                 765             


Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly 
    770                 775                 780                 


Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg 
785                 790                 795                 800 


Ser Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala 
                805                 810                 815     


Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg 
            820                 825                 830         


Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro 
        835                 840                 845             


Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala 
    850                 855                 860                 


Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln 
865                 870                 875                 880 


Ile Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val 
                885                 890                 895     


Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe 
            900                 905                 910         


Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser 
        915                 920                 925             


Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu 
    930                 935                 940                 


Asn Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser 
945                 950                 955                 960 


Val Leu Asn Asp Ile Leu Ser Arg Leu Asp Pro Pro Glu Ala Glu Val 
                965                 970                 975     


Gln Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser Leu Gln Thr Tyr 
            980                 985                 990         


Val Thr Gln Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
        995                 1000                 1005             


Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1010                 1015                 1020             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1025                 1030                 1035             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1040                 1045                 1050             


Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1055                 1060                 1065             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1070                 1075                 1080             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1085                 1090                 1095             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1100                 1105                 1110             


Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Ser 
    1115                 1120                 1125             


Glu Ile  Asp Ser Ile Lys Glu  Glu Ile Asp Lys Ile  His Lys Asn 
    1130                 1135                 1140             


Ile Asp  Ser Ile Lys Glu Glu  Ile Asp Lys Ile His  Lys Asn Gly 
    1145                 1150                 1155             


Ser Gly  Gly Ser Gly Asp Ile  Ile Lys Leu Leu Asn  Glu Gln Val 
    1160                 1165                 1170             


Asn Lys  Glu Met Gln Ser Ser  Asn Leu Tyr Met Ser  Met Ser Ser 
    1175                 1180                 1185             


Trp Cys  Tyr Thr His Ser Leu  Asp Gly Ala Gly Leu  Phe Leu Phe 
    1190                 1195                 1200             


Asp His  Ala Ala Glu Glu Tyr  Glu His Ala Lys Lys  Leu Ile Ile 
    1205                 1210                 1215             


Phe Leu  Asn Glu Asn Asn Val  Pro Val Gln Leu Thr  Ser Ile Ser 
    1220                 1225                 1230             


Ala Pro  Glu His Lys Phe Glu  Gly Leu Thr Gln Ile  Phe Gln Lys 
    1235                 1240                 1245             


Ala Tyr  Glu His Glu Gln His  Ile Ser Glu Ser Ile  Asn Asn Ile 
    1250                 1255                 1260             


Val Asp  His Ala Ile Lys Ser  Lys Asp His Ala Thr  Phe Asn Phe 
    1265                 1270                 1275             


Leu Gln  Trp Tyr Val Ala Glu  Gln His Glu Glu Glu  Val Leu Phe 
    1280                 1285                 1290             


Lys Asp  Ile Leu Asp Lys Ile  Glu Leu Ile Gly Asn  Glu Asn His 
    1295                 1300                 1305             


Gly Leu  Tyr Leu Ala Asp Gln  Tyr Val Lys Gly Ile  Ala Lys Ser 
    1310                 1315                 1320             


Arg Lys  Ser Gly Ser 
    1325             


<210> 79
<211> 1345
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 79
Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser 
1               5                   10                  15      


Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val 
            20                  25                  30          


Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr 
        35                  40                  45              


Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe 
    50                  55                  60                  


Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr 
65                  70                  75                  80  


Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp 
                85                  90                  95      


Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val 
            100                 105                 110         


Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val 
        115                 120                 125             


Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val 
    130                 135                 140                 


Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe 
145                 150                 155                 160 


Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu 
                165                 170                 175     


Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His 
            180                 185                 190         


Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu 
        195                 200                 205             


Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln 
    210                 215                 220                 


Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser 
225                 230                 235                 240 


Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln 
                245                 250                 255     


Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp 
            260                 265                 270         


Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu 
        275                 280                 285             


Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg 
    290                 295                 300                 


Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu 
305                 310                 315                 320 


Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr 
                325                 330                 335     


Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val 
            340                 345                 350         


Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser 
        355                 360                 365             


Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser 
    370                 375                 380                 


Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr 
385                 390                 395                 400 


Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly 
                405                 410                 415     


Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly 
            420                 425                 430         


Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro 
        435                 440                 445             


Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro 
    450                 455                 460                 


Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr 
465                 470                 475                 480 


Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val 
                485                 490                 495     


Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro 
            500                 505                 510         


Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe 
        515                 520                 525             


Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe 
    530                 535                 540                 


Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala 
545                 550                 555                 560 


Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser 
                565                 570                 575     


Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln 
            580                 585                 590         


Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala 
        595                 600                 605             


Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly 
    610                 615                 620                 


Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His 
625                 630                 635                 640 


Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys 
                645                 650                 655     


Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro Gly Ser Ala Ser Ser Val 
            660                 665                 670         


Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn 
        675                 680                 685             


Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr 
    690                 695                 700                 


Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser 
705                 710                 715                 720 


Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn 
                725                 730                 735     


Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu 
            740                 745                 750         


Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala 
        755                 760                 765             


Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly 
    770                 775                 780                 


Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg 
785                 790                 795                 800 


Ser Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala 
                805                 810                 815     


Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg 
            820                 825                 830         


Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro 
        835                 840                 845             


Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala 
    850                 855                 860                 


Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln 
865                 870                 875                 880 


Ile Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val 
                885                 890                 895     


Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe 
            900                 905                 910         


Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser 
        915                 920                 925             


Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu 
    930                 935                 940                 


Asn Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser 
945                 950                 955                 960 


Val Leu Asn Asp Ile Leu Ser Arg Leu Asp Pro Pro Glu Ala Glu Val 
                965                 970                 975     


Gln Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser Leu Gln Thr Tyr 
            980                 985                 990         


Val Thr Gln Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
        995                 1000                 1005             


Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1010                 1015                 1020             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1025                 1030                 1035             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1040                 1045                 1050             


Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1055                 1060                 1065             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1070                 1075                 1080             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1085                 1090                 1095             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1100                 1105                 1110             


Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Ser 
    1115                 1120                 1125             


Glu Leu  Asp Ser Ile Lys Glu  Glu Leu Asp Lys Ile  His Lys Asn 
    1130                 1135                 1140             


Met Lys  Gln Ile Glu Asp Lys  Ile Glu Glu Ile Leu  Ser Lys Ile 
    1145                 1150                 1155             


Tyr His  Ile Glu Asn Glu Ile  Ala Arg Ile Lys Lys  Leu Ile Gly 
    1160                 1165                 1170             


Arg Gly  Ser Gly Gly Ser Gly  Asp Ile Ile Lys Leu  Leu Asn Glu 
    1175                 1180                 1185             


Gln Val  Asn Lys Glu Met Gln  Ser Ser Asn Leu Tyr  Met Ser Met 
    1190                 1195                 1200             


Ser Ser  Trp Cys Tyr Thr His  Ser Leu Asp Gly Ala  Gly Leu Phe 
    1205                 1210                 1215             


Leu Phe  Asp His Ala Ala Glu  Glu Tyr Glu His Ala  Lys Lys Leu 
    1220                 1225                 1230             


Ile Ile  Phe Leu Asn Glu Asn  Asn Val Pro Val Gln  Leu Thr Ser 
    1235                 1240                 1245             


Ile Ser  Ala Pro Glu His Lys  Phe Glu Gly Leu Thr  Gln Ile Phe 
    1250                 1255                 1260             


Gln Lys  Ala Tyr Glu His Glu  Gln His Ile Ser Glu  Ser Ile Asn 
    1265                 1270                 1275             


Asn Ile  Val Asp His Ala Ile  Lys Ser Lys Asp His  Ala Thr Phe 
    1280                 1285                 1290             


Asn Phe  Leu Gln Trp Tyr Val  Ala Glu Gln His Glu  Glu Glu Val 
    1295                 1300                 1305             


Leu Phe  Lys Asp Ile Leu Asp  Lys Ile Glu Leu Ile  Gly Asn Glu 
    1310                 1315                 1320             


Asn His  Gly Leu Tyr Leu Ala  Asp Gln Tyr Val Lys  Gly Ile Ala 
    1325                 1330                 1335             


Lys Ser  Arg Lys Ser Gly Ser  
    1340                 1345 


<210> 80
<211> 1295
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 80
Ser Ser Gln Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala 
1               5                   10                  15      


Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe 
            20                  25                  30          


Arg Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe 
        35                  40                  45              


Ser Asn Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly 
    50                  55                  60                  


Thr Lys Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr 
65                  70                  75                  80  


Phe Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly 
                85                  90                  95      


Thr Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala 
            100                 105                 110         


Thr Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro 
        115                 120                 125             


Phe Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser 
    130                 135                 140                 


Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val 
145                 150                 155                 160 


Ser Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys 
                165                 170                 175     


Asn Leu Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile 
            180                 185                 190         


Tyr Ser Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly 
        195                 200                 205             


Phe Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile 
    210                 215                 220                 


Thr Arg Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro 
225                 230                 235                 240 


Gly Asp Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val 
                245                 250                 255     


Gly Tyr Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly 
            260                 265                 270         


Thr Ile Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr 
        275                 280                 285             


Lys Cys Thr Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr 
    290                 295                 300                 


Ser Asn Phe Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn 
305                 310                 315                 320 


Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe 
                325                 330                 335     


Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala 
            340                 345                 350         


Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys 
        355                 360                 365             


Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val 
    370                 375                 380                 


Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala 
385                 390                 395                 400 


Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp 
                405                 410                 415     


Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser 
            420                 425                 430         


Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser 
        435                 440                 445             


Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala 
    450                 455                 460                 


Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro 
465                 470                 475                 480 


Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro 
                485                 490                 495     


Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr 
            500                 505                 510         


Val Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val 
        515                 520                 525             


Asn Phe Asn Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser 
    530                 535                 540                 


Asn Lys Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp 
545                 550                 555                 560 


Thr Thr Asp Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile 
                565                 570                 575     


Thr Pro Cys Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn 
            580                 585                 590         


Thr Ser Asn Gln Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu 
        595                 600                 605             


Val Pro Val Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val 
    610                 615                 620                 


Tyr Ser Thr Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile 
625                 630                 635                 640 


Gly Ala Glu His Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly 
                645                 650                 655     


Ala Gly Ile Cys Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro Gly Ser 
            660                 665                 670         


Ala Ser Ser Val Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu 
        675                 680                 685             


Gly Ala Glu Asn Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro 
    690                 695                 700                 


Thr Asn Phe Thr Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met 
705                 710                 715                 720 


Thr Lys Thr Ser Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr 
                725                 730                 735     


Glu Cys Ser Asn Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu 
            740                 745                 750         


Asn Arg Ala Leu Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln 
        755                 760                 765             


Glu Val Phe Ala Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys 
    770                 775                 780                 


Asp Phe Gly Gly Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys 
785                 790                 795                 800 


Pro Ser Lys Arg Ser Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr 
                805                 810                 815     


Leu Ala Asp Ala Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp 
            820                 825                 830         


Ile Ala Ala Arg Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr 
        835                 840                 845             


Val Leu Pro Pro Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser 
    850                 855                 860                 


Ala Leu Leu Ala Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly 
865                 870                 875                 880 


Ala Ala Leu Gln Ile Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn 
                885                 890                 895     


Gly Ile Gly Val Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile 
            900                 905                 910         


Ala Asn Gln Phe Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser 
        915                 920                 925             


Ser Thr Ala Ser Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn 
    930                 935                 940                 


Ala Gln Ala Leu Asn Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly 
945                 950                 955                 960 


Ala Ile Ser Ser Val Leu Asn Asp Ile Leu Ser Arg Leu Asp Pro Pro 
                965                 970                 975     


Glu Ala Glu Val Gln Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser 
            980                 985                 990         


Leu Gln Thr Tyr Val Thr Gln Gln  Leu Ile Arg Ala Ala  Glu Ile Arg 
        995                 1000                 1005             


Ala Ser  Ala Asn Leu Ala Ala  Thr Lys Met Ser Glu  Cys Val Leu 
    1010                 1015                 1020             


Gly Gln  Ser Lys Arg Val Asp  Phe Cys Gly Lys Gly  Tyr His Leu 
    1025                 1030                 1035             


Met Ser  Phe Pro Gln Ser Ala  Pro His Gly Val Val  Phe Leu His 
    1040                 1045                 1050             


Val Thr  Tyr Val Pro Ala Gln  Glu Lys Asn Phe Thr  Thr Ala Pro 
    1055                 1060                 1065             


Ala Ile  Cys His Asp Gly Lys  Ala His Phe Pro Arg  Glu Gly Val 
    1070                 1075                 1080             


Phe Val  Ser Asn Gly Thr His  Trp Phe Val Thr Gln  Arg Asn Phe 
    1085                 1090                 1095             


Tyr Glu  Pro Gln Ile Ile Thr  Thr Asp Asn Thr Phe  Val Ser Gly 
    1100                 1105                 1110             


Asn Cys  Asp Val Val Ile Gly  Ile Val Asn Asn Thr  Val Gly Ser 
    1115                 1120                 1125             


Gly Gly  Asp Ile Ile Lys Leu  Leu Asn Glu Gln Val  Asn Lys Glu 
    1130                 1135                 1140             


Met Gln  Ser Ser Asn Leu Tyr  Met Ser Met Ser Ser  Trp Cys Tyr 
    1145                 1150                 1155             


Thr His  Ser Leu Asp Gly Ala  Gly Leu Phe Leu Phe  Asp His Ala 
    1160                 1165                 1170             


Ala Glu  Glu Tyr Glu His Ala  Lys Lys Leu Ile Ile  Phe Leu Asn 
    1175                 1180                 1185             


Glu Asn  Asn Val Pro Val Gln  Leu Thr Ser Ile Ser  Ala Pro Glu 
    1190                 1195                 1200             


His Lys  Phe Glu Gly Leu Thr  Gln Ile Phe Gln Lys  Ala Tyr Glu 
    1205                 1210                 1215             


His Glu  Gln His Ile Ser Glu  Ser Ile Asn Asn Ile  Val Asp His 
    1220                 1225                 1230             


Ala Ile  Lys Ser Lys Asp His  Ala Thr Phe Asn Phe  Leu Gln Trp 
    1235                 1240                 1245             


Tyr Val  Ala Glu Gln His Glu  Glu Glu Val Leu Phe  Lys Asp Ile 
    1250                 1255                 1260             


Leu Asp  Lys Ile Glu Leu Ile  Gly Asn Glu Asn His  Gly Leu Tyr 
    1265                 1270                 1275             


Leu Ala  Asp Gln Tyr Val Lys  Gly Ile Ala Lys Ser  Arg Lys Ser 
    1280                 1285                 1290             


Gly Ser  
    1295 


<210> 81
<211> 1297
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 81
Ser Ser Gln Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala 
1               5                   10                  15      


Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe 
            20                  25                  30          


Arg Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe 
        35                  40                  45              


Ser Asn Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly 
    50                  55                  60                  


Thr Lys Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr 
65                  70                  75                  80  


Phe Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly 
                85                  90                  95      


Thr Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala 
            100                 105                 110         


Thr Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro 
        115                 120                 125             


Phe Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser 
    130                 135                 140                 


Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val 
145                 150                 155                 160 


Ser Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys 
                165                 170                 175     


Asn Leu Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile 
            180                 185                 190         


Tyr Ser Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly 
        195                 200                 205             


Phe Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile 
    210                 215                 220                 


Thr Arg Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro 
225                 230                 235                 240 


Gly Asp Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val 
                245                 250                 255     


Gly Tyr Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly 
            260                 265                 270         


Thr Ile Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr 
        275                 280                 285             


Lys Cys Thr Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr 
    290                 295                 300                 


Ser Asn Phe Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn 
305                 310                 315                 320 


Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe 
                325                 330                 335     


Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala 
            340                 345                 350         


Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys 
        355                 360                 365             


Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val 
    370                 375                 380                 


Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala 
385                 390                 395                 400 


Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp 
                405                 410                 415     


Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser 
            420                 425                 430         


Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser 
        435                 440                 445             


Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala 
    450                 455                 460                 


Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro 
465                 470                 475                 480 


Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro 
                485                 490                 495     


Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr 
            500                 505                 510         


Val Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val 
        515                 520                 525             


Asn Phe Asn Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser 
    530                 535                 540                 


Asn Lys Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp 
545                 550                 555                 560 


Thr Thr Asp Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile 
                565                 570                 575     


Thr Pro Cys Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn 
            580                 585                 590         


Thr Ser Asn Gln Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu 
        595                 600                 605             


Val Pro Val Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val 
    610                 615                 620                 


Tyr Ser Thr Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile 
625                 630                 635                 640 


Gly Ala Glu His Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly 
                645                 650                 655     


Ala Gly Ile Cys Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro Gly Ser 
            660                 665                 670         


Ala Ser Ser Val Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu 
        675                 680                 685             


Gly Ala Glu Asn Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro 
    690                 695                 700                 


Thr Asn Phe Thr Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met 
705                 710                 715                 720 


Thr Lys Thr Ser Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr 
                725                 730                 735     


Glu Cys Ser Asn Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu 
            740                 745                 750         


Asn Arg Ala Leu Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln 
        755                 760                 765             


Glu Val Phe Ala Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys 
    770                 775                 780                 


Asp Phe Gly Gly Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys 
785                 790                 795                 800 


Pro Ser Lys Arg Ser Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr 
                805                 810                 815     


Leu Ala Asp Ala Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp 
            820                 825                 830         


Ile Ala Ala Arg Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr 
        835                 840                 845             


Val Leu Pro Pro Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser 
    850                 855                 860                 


Ala Leu Leu Ala Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly 
865                 870                 875                 880 


Ala Ala Leu Gln Ile Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn 
                885                 890                 895     


Gly Ile Gly Val Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile 
            900                 905                 910         


Ala Asn Gln Phe Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser 
        915                 920                 925             


Ser Thr Ala Ser Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn 
    930                 935                 940                 


Ala Gln Ala Leu Asn Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly 
945                 950                 955                 960 


Ala Ile Ser Ser Val Leu Asn Asp Ile Leu Ser Arg Leu Asp Pro Pro 
                965                 970                 975     


Glu Ala Glu Val Gln Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser 
            980                 985                 990         


Leu Gln Thr Tyr Val Thr Gln Gln  Leu Ile Arg Ala Ala  Glu Ile Arg 
        995                 1000                 1005             


Ala Ser  Ala Asn Leu Ala Ala  Thr Lys Met Ser Glu  Cys Val Leu 
    1010                 1015                 1020             


Gly Gln  Ser Lys Arg Val Asp  Phe Cys Gly Lys Gly  Tyr His Leu 
    1025                 1030                 1035             


Met Ser  Phe Pro Gln Ser Ala  Pro His Gly Val Val  Phe Leu His 
    1040                 1045                 1050             


Val Thr  Tyr Val Pro Ala Gln  Glu Lys Asn Phe Thr  Thr Ala Pro 
    1055                 1060                 1065             


Ala Ile  Cys His Asp Gly Lys  Ala His Phe Pro Arg  Glu Gly Val 
    1070                 1075                 1080             


Phe Val  Ser Asn Gly Thr His  Trp Phe Val Thr Gln  Arg Asn Phe 
    1085                 1090                 1095             


Tyr Glu  Pro Gln Ile Ile Thr  Thr Asp Asn Thr Phe  Val Ser Gly 
    1100                 1105                 1110             


Asn Cys  Asp Val Val Ile Gly  Ile Val Asn Asn Thr  Val Gly Ser 
    1115                 1120                 1125             


Gly Gly  Ser Gly Asp Ile Ile  Lys Leu Leu Asn Glu  Gln Val Asn 
    1130                 1135                 1140             


Lys Glu  Met Gln Ser Ser Asn  Leu Tyr Met Ser Met  Ser Ser Trp 
    1145                 1150                 1155             


Cys Tyr  Thr His Ser Leu Asp  Gly Ala Gly Leu Phe  Leu Phe Asp 
    1160                 1165                 1170             


His Ala  Ala Glu Glu Tyr Glu  His Ala Lys Lys Leu  Ile Ile Phe 
    1175                 1180                 1185             


Leu Asn  Glu Asn Asn Val Pro  Val Gln Leu Thr Ser  Ile Ser Ala 
    1190                 1195                 1200             


Pro Glu  His Lys Phe Glu Gly  Leu Thr Gln Ile Phe  Gln Lys Ala 
    1205                 1210                 1215             


Tyr Glu  His Glu Gln His Ile  Ser Glu Ser Ile Asn  Asn Ile Val 
    1220                 1225                 1230             


Asp His  Ala Ile Lys Ser Lys  Asp His Ala Thr Phe  Asn Phe Leu 
    1235                 1240                 1245             


Gln Trp  Tyr Val Ala Glu Gln  His Glu Glu Glu Val  Leu Phe Lys 
    1250                 1255                 1260             


Asp Ile  Leu Asp Lys Ile Glu  Leu Ile Gly Asn Glu  Asn His Gly 
    1265                 1270                 1275             


Leu Tyr  Leu Ala Asp Gln Tyr  Val Lys Gly Ile Ala  Lys Ser Arg 
    1280                 1285                 1290             


Lys Ser  Gly Ser 
    1295         


<210> 82
<211> 1368
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 82
Ser Ser Gln Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala 
1               5                   10                  15      


Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe 
            20                  25                  30          


Arg Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe 
        35                  40                  45              


Ser Asn Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly 
    50                  55                  60                  


Thr Lys Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr 
65                  70                  75                  80  


Phe Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly 
                85                  90                  95      


Thr Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala 
            100                 105                 110         


Thr Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro 
        115                 120                 125             


Phe Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser 
    130                 135                 140                 


Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val 
145                 150                 155                 160 


Ser Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys 
                165                 170                 175     


Asn Leu Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile 
            180                 185                 190         


Tyr Ser Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly 
        195                 200                 205             


Phe Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile 
    210                 215                 220                 


Thr Arg Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro 
225                 230                 235                 240 


Gly Asp Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val 
                245                 250                 255     


Gly Tyr Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly 
            260                 265                 270         


Thr Ile Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr 
        275                 280                 285             


Lys Cys Thr Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr 
    290                 295                 300                 


Ser Asn Phe Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn 
305                 310                 315                 320 


Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe 
                325                 330                 335     


Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala 
            340                 345                 350         


Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys 
        355                 360                 365             


Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val 
    370                 375                 380                 


Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala 
385                 390                 395                 400 


Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp 
                405                 410                 415     


Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser 
            420                 425                 430         


Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser 
        435                 440                 445             


Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala 
    450                 455                 460                 


Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro 
465                 470                 475                 480 


Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro 
                485                 490                 495     


Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr 
            500                 505                 510         


Val Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val 
        515                 520                 525             


Asn Phe Asn Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser 
    530                 535                 540                 


Asn Lys Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp 
545                 550                 555                 560 


Thr Thr Asp Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile 
                565                 570                 575     


Thr Pro Cys Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn 
            580                 585                 590         


Thr Ser Asn Gln Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu 
        595                 600                 605             


Val Pro Val Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val 
    610                 615                 620                 


Tyr Ser Thr Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile 
625                 630                 635                 640 


Gly Ala Glu His Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly 
                645                 650                 655     


Ala Gly Ile Cys Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro Gly Ser 
            660                 665                 670         


Ala Ser Ser Val Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu 
        675                 680                 685             


Gly Ala Glu Asn Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro 
    690                 695                 700                 


Thr Asn Phe Thr Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met 
705                 710                 715                 720 


Thr Lys Thr Ser Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr 
                725                 730                 735     


Glu Cys Ser Asn Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu 
            740                 745                 750         


Asn Arg Ala Leu Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln 
        755                 760                 765             


Glu Val Phe Ala Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys 
    770                 775                 780                 


Asp Phe Gly Gly Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys 
785                 790                 795                 800 


Pro Ser Lys Arg Ser Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr 
                805                 810                 815     


Leu Ala Asp Ala Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp 
            820                 825                 830         


Ile Ala Ala Arg Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr 
        835                 840                 845             


Val Leu Pro Pro Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser 
    850                 855                 860                 


Ala Leu Leu Ala Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly 
865                 870                 875                 880 


Ala Ala Leu Gln Ile Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn 
                885                 890                 895     


Gly Ile Gly Val Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile 
            900                 905                 910         


Ala Asn Gln Phe Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser 
        915                 920                 925             


Ser Thr Ala Ser Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn 
    930                 935                 940                 


Ala Gln Ala Leu Asn Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly 
945                 950                 955                 960 


Ala Ile Ser Ser Val Leu Asn Asp Ile Leu Ser Arg Leu Asp Pro Pro 
                965                 970                 975     


Glu Ala Glu Val Gln Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser 
            980                 985                 990         


Leu Gln Thr Tyr Val Thr Gln Gln  Leu Ile Arg Ala Ala  Glu Ile Arg 
        995                 1000                 1005             


Ala Ser  Ala Asn Leu Ala Ala  Thr Lys Met Ser Glu  Cys Val Leu 
    1010                 1015                 1020             


Gly Gln  Ser Lys Arg Val Asp  Phe Cys Gly Lys Gly  Tyr His Leu 
    1025                 1030                 1035             


Met Ser  Phe Pro Gln Ser Ala  Pro His Gly Val Val  Phe Leu His 
    1040                 1045                 1050             


Val Thr  Tyr Val Pro Ala Gln  Glu Lys Asn Phe Thr  Thr Ala Pro 
    1055                 1060                 1065             


Ala Ile  Cys His Asp Gly Lys  Ala His Phe Pro Arg  Glu Gly Val 
    1070                 1075                 1080             


Phe Val  Ser Asn Gly Thr His  Trp Phe Val Thr Gln  Arg Asn Phe 
    1085                 1090                 1095             


Tyr Glu  Pro Gln Ile Ile Thr  Thr Asp Asn Thr Phe  Val Ser Gly 
    1100                 1105                 1110             


Asn Cys  Asp Val Val Ile Gly  Ile Val Asn Asn Thr  Val Tyr Asp 
    1115                 1120                 1125             


Pro Leu  Gln Pro Glu Leu Asp  Ser Phe Lys Glu Glu  Leu Asp Lys 
    1130                 1135                 1140             


Tyr Phe  Lys Asn His Thr Ser  Pro Asp Val Asp Leu  Gly Asp Ile 
    1145                 1150                 1155             


Ser Gly  Ile Asn Ala Ser Val  Val Asn Ile Gln Lys  Glu Ile Asp 
    1160                 1165                 1170             


Arg Leu  Asn Glu Val Ala Lys  Asn Leu Asn Glu Ser  Leu Ile Asp 
    1175                 1180                 1185             


Leu Gln  Glu Leu Gly Lys Tyr  Glu Gln Gly Ser Gly  Gly Ser Gly 
    1190                 1195                 1200             


Asp Ile  Ile Lys Leu Leu Asn  Glu Gln Val Asn Lys  Glu Met Gln 
    1205                 1210                 1215             


Ser Ser  Asn Leu Tyr Met Ser  Met Ser Ser Trp Cys  Tyr Thr His 
    1220                 1225                 1230             


Ser Leu  Asp Gly Ala Gly Leu  Phe Leu Phe Asp His  Ala Ala Glu 
    1235                 1240                 1245             


Glu Tyr  Glu His Ala Lys Lys  Leu Ile Ile Phe Leu  Asn Glu Asn 
    1250                 1255                 1260             


Asn Val  Pro Val Gln Leu Thr  Ser Ile Ser Ala Pro  Glu His Lys 
    1265                 1270                 1275             


Phe Glu  Gly Leu Thr Gln Ile  Phe Gln Lys Ala Tyr  Glu His Glu 
    1280                 1285                 1290             


Gln His  Ile Ser Glu Ser Ile  Asn Asn Ile Val Asp  His Ala Ile 
    1295                 1300                 1305             


Lys Ser  Lys Asp His Ala Thr  Phe Asn Phe Leu Gln  Trp Tyr Val 
    1310                 1315                 1320             


Ala Glu  Gln His Glu Glu Glu  Val Leu Phe Lys Asp  Ile Leu Asp 
    1325                 1330                 1335             


Lys Ile  Glu Leu Ile Gly Asn  Glu Asn His Gly Leu  Tyr Leu Ala 
    1340                 1345                 1350             


Asp Gln  Tyr Val Lys Gly Ile  Ala Lys Ser Arg Lys  Ser Gly Ser 
    1355                 1360                 1365             


<210> 83
<211> 1404
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 83
Ser Ser Gln Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala 
1               5                   10                  15      


Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe 
            20                  25                  30          


Arg Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe 
        35                  40                  45              


Ser Asn Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly 
    50                  55                  60                  


Thr Lys Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr 
65                  70                  75                  80  


Phe Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly 
                85                  90                  95      


Thr Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala 
            100                 105                 110         


Thr Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro 
        115                 120                 125             


Phe Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser 
    130                 135                 140                 


Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val 
145                 150                 155                 160 


Ser Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys 
                165                 170                 175     


Asn Leu Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile 
            180                 185                 190         


Tyr Ser Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly 
        195                 200                 205             


Phe Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile 
    210                 215                 220                 


Thr Arg Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro 
225                 230                 235                 240 


Gly Asp Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val 
                245                 250                 255     


Gly Tyr Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly 
            260                 265                 270         


Thr Ile Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr 
        275                 280                 285             


Lys Cys Thr Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr 
    290                 295                 300                 


Ser Asn Phe Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn 
305                 310                 315                 320 


Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe 
                325                 330                 335     


Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala 
            340                 345                 350         


Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys 
        355                 360                 365             


Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val 
    370                 375                 380                 


Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala 
385                 390                 395                 400 


Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp 
                405                 410                 415     


Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser 
            420                 425                 430         


Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser 
        435                 440                 445             


Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala 
    450                 455                 460                 


Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro 
465                 470                 475                 480 


Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro 
                485                 490                 495     


Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr 
            500                 505                 510         


Val Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val 
        515                 520                 525             


Asn Phe Asn Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser 
    530                 535                 540                 


Asn Lys Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp 
545                 550                 555                 560 


Thr Thr Asp Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile 
                565                 570                 575     


Thr Pro Cys Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn 
            580                 585                 590         


Thr Ser Asn Gln Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu 
        595                 600                 605             


Val Pro Val Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val 
    610                 615                 620                 


Tyr Ser Thr Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile 
625                 630                 635                 640 


Gly Ala Glu His Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly 
                645                 650                 655     


Ala Gly Ile Cys Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro Gly Ser 
            660                 665                 670         


Ala Ser Ser Val Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu 
        675                 680                 685             


Gly Ala Glu Asn Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro 
    690                 695                 700                 


Thr Asn Phe Thr Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met 
705                 710                 715                 720 


Thr Lys Thr Ser Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr 
                725                 730                 735     


Glu Cys Ser Asn Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu 
            740                 745                 750         


Asn Arg Ala Leu Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln 
        755                 760                 765             


Glu Val Phe Ala Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys 
    770                 775                 780                 


Asp Phe Gly Gly Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys 
785                 790                 795                 800 


Pro Ser Lys Arg Ser Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr 
                805                 810                 815     


Leu Ala Asp Ala Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp 
            820                 825                 830         


Ile Ala Ala Arg Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr 
        835                 840                 845             


Val Leu Pro Pro Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser 
    850                 855                 860                 


Ala Leu Leu Ala Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly 
865                 870                 875                 880 


Ala Ala Leu Gln Ile Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn 
                885                 890                 895     


Gly Ile Gly Val Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile 
            900                 905                 910         


Ala Asn Gln Phe Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser 
        915                 920                 925             


Ser Thr Ala Ser Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn 
    930                 935                 940                 


Ala Gln Ala Leu Asn Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly 
945                 950                 955                 960 


Ala Ile Ser Ser Val Leu Asn Asp Ile Leu Ser Arg Leu Asp Pro Pro 
                965                 970                 975     


Glu Ala Glu Val Gln Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser 
            980                 985                 990         


Leu Gln Thr Tyr Val Thr Gln Gln  Leu Ile Arg Ala Ala  Glu Ile Arg 
        995                 1000                 1005             


Ala Ser  Ala Asn Leu Ala Ala  Thr Lys Met Ser Glu  Cys Val Leu 
    1010                 1015                 1020             


Gly Gln  Ser Lys Arg Val Asp  Phe Cys Gly Lys Gly  Tyr His Leu 
    1025                 1030                 1035             


Met Ser  Phe Pro Gln Ser Ala  Pro His Gly Val Val  Phe Leu His 
    1040                 1045                 1050             


Val Thr  Tyr Val Pro Ala Gln  Glu Lys Asn Phe Thr  Thr Ala Pro 
    1055                 1060                 1065             


Ala Ile  Cys His Asp Gly Lys  Ala His Phe Pro Arg  Glu Gly Val 
    1070                 1075                 1080             


Phe Val  Ser Asn Gly Thr His  Trp Phe Val Thr Gln  Arg Asn Phe 
    1085                 1090                 1095             


Tyr Glu  Pro Gln Ile Ile Thr  Thr Asp Asn Thr Phe  Val Ser Gly 
    1100                 1105                 1110             


Asn Cys  Asp Val Val Ile Gly  Ile Val Asn Asn Thr  Val Tyr Asp 
    1115                 1120                 1125             


Pro Leu  Gln Pro Glu Leu Asp  Ser Phe Lys Glu Glu  Leu Asp Lys 
    1130                 1135                 1140             


Tyr Phe  Lys Asn His Thr Ser  Pro Asp Val Asp Leu  Gly Asp Ile 
    1145                 1150                 1155             


Ser Gly  Ile Asn Ala Ser Val  Val Asn Ile Gln Lys  Glu Ile Asp 
    1160                 1165                 1170             


Arg Leu  Asn Glu Val Ala Lys  Asn Leu Asn Glu Ser  Leu Ile Asp 
    1175                 1180                 1185             


Leu Gln  Glu Leu Gly Lys Tyr  Glu Gln Gly Ser Gly  Gly Glu Met 
    1190                 1195                 1200             


Lys Gln  Ile Glu Asp Lys Ile  Glu Glu Ile Leu Ser  Lys Ile Tyr 
    1205                 1210                 1215             


His Ile  Glu Asn Glu Ile Ala  Arg Ile Lys Lys Leu  Ile Gly Arg 
    1220                 1225                 1230             


Gly Ser  Gly Gly Ser Gly Asp  Ile Ile Lys Leu Leu  Asn Glu Gln 
    1235                 1240                 1245             


Val Asn  Lys Glu Met Gln Ser  Ser Asn Leu Tyr Met  Ser Met Ser 
    1250                 1255                 1260             


Ser Trp  Cys Tyr Thr His Ser  Leu Asp Gly Ala Gly  Leu Phe Leu 
    1265                 1270                 1275             


Phe Asp  His Ala Ala Glu Glu  Tyr Glu His Ala Lys  Lys Leu Ile 
    1280                 1285                 1290             


Ile Phe  Leu Asn Glu Asn Asn  Val Pro Val Gln Leu  Thr Ser Ile 
    1295                 1300                 1305             


Ser Ala  Pro Glu His Lys Phe  Glu Gly Leu Thr Gln  Ile Phe Gln 
    1310                 1315                 1320             


Lys Ala  Tyr Glu His Glu Gln  His Ile Ser Glu Ser  Ile Asn Asn 
    1325                 1330                 1335             


Ile Val  Asp His Ala Ile Lys  Ser Lys Asp His Ala  Thr Phe Asn 
    1340                 1345                 1350             


Phe Leu  Gln Trp Tyr Val Ala  Glu Gln His Glu Glu  Glu Val Leu 
    1355                 1360                 1365             


Phe Lys  Asp Ile Leu Asp Lys  Ile Glu Leu Ile Gly  Asn Glu Asn 
    1370                 1375                 1380             


His Gly  Leu Tyr Leu Ala Asp  Gln Tyr Val Lys Gly  Ile Ala Lys 
    1385                 1390                 1395             


Ser Arg  Lys Ser Gly Ser 
    1400                 


<210> 84
<211> 1314
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 84
Ser Ser Gln Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala 
1               5                   10                  15      


Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe 
            20                  25                  30          


Arg Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe 
        35                  40                  45              


Ser Asn Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly 
    50                  55                  60                  


Thr Lys Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr 
65                  70                  75                  80  


Phe Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly 
                85                  90                  95      


Thr Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala 
            100                 105                 110         


Thr Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro 
        115                 120                 125             


Phe Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser 
    130                 135                 140                 


Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val 
145                 150                 155                 160 


Ser Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys 
                165                 170                 175     


Asn Leu Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile 
            180                 185                 190         


Tyr Ser Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly 
        195                 200                 205             


Phe Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile 
    210                 215                 220                 


Thr Arg Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro 
225                 230                 235                 240 


Gly Asp Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val 
                245                 250                 255     


Gly Tyr Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly 
            260                 265                 270         


Thr Ile Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr 
        275                 280                 285             


Lys Cys Thr Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr 
    290                 295                 300                 


Ser Asn Phe Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn 
305                 310                 315                 320 


Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe 
                325                 330                 335     


Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala 
            340                 345                 350         


Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys 
        355                 360                 365             


Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val 
    370                 375                 380                 


Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala 
385                 390                 395                 400 


Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp 
                405                 410                 415     


Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser 
            420                 425                 430         


Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser 
        435                 440                 445             


Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala 
    450                 455                 460                 


Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro 
465                 470                 475                 480 


Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro 
                485                 490                 495     


Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr 
            500                 505                 510         


Val Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val 
        515                 520                 525             


Asn Phe Asn Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser 
    530                 535                 540                 


Asn Lys Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp 
545                 550                 555                 560 


Thr Thr Asp Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile 
                565                 570                 575     


Thr Pro Cys Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn 
            580                 585                 590         


Thr Ser Asn Gln Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu 
        595                 600                 605             


Val Pro Val Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val 
    610                 615                 620                 


Tyr Ser Thr Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile 
625                 630                 635                 640 


Gly Ala Glu His Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly 
                645                 650                 655     


Ala Gly Ile Cys Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro Gly Ser 
            660                 665                 670         


Ala Ser Ser Val Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu 
        675                 680                 685             


Gly Ala Glu Asn Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro 
    690                 695                 700                 


Thr Asn Phe Thr Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met 
705                 710                 715                 720 


Thr Lys Thr Ser Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr 
                725                 730                 735     


Glu Cys Ser Asn Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu 
            740                 745                 750         


Asn Arg Ala Leu Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln 
        755                 760                 765             


Glu Val Phe Ala Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys 
    770                 775                 780                 


Asp Phe Gly Gly Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys 
785                 790                 795                 800 


Pro Ser Lys Arg Ser Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr 
                805                 810                 815     


Leu Ala Asp Ala Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp 
            820                 825                 830         


Ile Ala Ala Arg Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr 
        835                 840                 845             


Val Leu Pro Pro Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser 
    850                 855                 860                 


Ala Leu Leu Ala Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly 
865                 870                 875                 880 


Ala Ala Leu Gln Ile Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn 
                885                 890                 895     


Gly Ile Gly Val Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile 
            900                 905                 910         


Ala Asn Gln Phe Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser 
        915                 920                 925             


Ser Thr Ala Ser Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn 
    930                 935                 940                 


Ala Gln Ala Leu Asn Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly 
945                 950                 955                 960 


Ala Ile Ser Ser Val Leu Asn Asp Ile Leu Ser Arg Leu Asp Pro Pro 
                965                 970                 975     


Glu Ala Glu Val Gln Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser 
            980                 985                 990         


Leu Gln Thr Tyr Val Thr Gln Gln  Leu Ile Arg Ala Ala  Glu Ile Arg 
        995                 1000                 1005             


Ala Ser  Ala Asn Leu Ala Ala  Thr Lys Met Ser Glu  Cys Val Leu 
    1010                 1015                 1020             


Gly Gln  Ser Lys Arg Val Asp  Phe Cys Gly Lys Gly  Tyr His Leu 
    1025                 1030                 1035             


Met Ser  Phe Pro Gln Ser Ala  Pro His Gly Val Val  Phe Leu His 
    1040                 1045                 1050             


Val Thr  Tyr Val Pro Ala Gln  Glu Lys Asn Phe Thr  Thr Ala Pro 
    1055                 1060                 1065             


Ala Ile  Cys His Asp Gly Lys  Ala His Phe Pro Arg  Glu Gly Val 
    1070                 1075                 1080             


Phe Val  Ser Asn Gly Thr His  Trp Phe Val Thr Gln  Arg Asn Phe 
    1085                 1090                 1095             


Tyr Glu  Pro Gln Ile Ile Thr  Thr Asp Asn Thr Phe  Val Ser Gly 
    1100                 1105                 1110             


Asn Cys  Asp Val Val Ile Gly  Ile Val Asn Asn Thr  Val Tyr Asp 
    1115                 1120                 1125             


Pro Leu  Gln Pro Glu Leu Asp  Ser Phe Lys Glu Glu  Leu Asp Lys 
    1130                 1135                 1140             


Gly Ser  Gly Gly Ser Gly Asp  Ile Ile Lys Leu Leu  Asn Glu Gln 
    1145                 1150                 1155             


Val Asn  Lys Glu Met Gln Ser  Ser Asn Leu Tyr Met  Ser Met Ser 
    1160                 1165                 1170             


Ser Trp  Cys Tyr Thr His Ser  Leu Asp Gly Ala Gly  Leu Phe Leu 
    1175                 1180                 1185             


Phe Asp  His Ala Ala Glu Glu  Tyr Glu His Ala Lys  Lys Leu Ile 
    1190                 1195                 1200             


Ile Phe  Leu Asn Glu Asn Asn  Val Pro Val Gln Leu  Thr Ser Ile 
    1205                 1210                 1215             


Ser Ala  Pro Glu His Lys Phe  Glu Gly Leu Thr Gln  Ile Phe Gln 
    1220                 1225                 1230             


Lys Ala  Tyr Glu His Glu Gln  His Ile Ser Glu Ser  Ile Asn Asn 
    1235                 1240                 1245             


Ile Val  Asp His Ala Ile Lys  Ser Lys Asp His Ala  Thr Phe Asn 
    1250                 1255                 1260             


Phe Leu  Gln Trp Tyr Val Ala  Glu Gln His Glu Glu  Glu Val Leu 
    1265                 1270                 1275             


Phe Lys  Asp Ile Leu Asp Lys  Ile Glu Leu Ile Gly  Asn Glu Asn 
    1280                 1285                 1290             


His Gly  Leu Tyr Leu Ala Asp  Gln Tyr Val Lys Gly  Ile Ala Lys 
    1295                 1300                 1305             


Ser Arg  Lys Ser Gly Ser 
    1310                 


<210> 85
<211> 1318
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 85
Ser Ser Gln Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala 
1               5                   10                  15      


Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe 
            20                  25                  30          


Arg Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe 
        35                  40                  45              


Ser Asn Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly 
    50                  55                  60                  


Thr Lys Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr 
65                  70                  75                  80  


Phe Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly 
                85                  90                  95      


Thr Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala 
            100                 105                 110         


Thr Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro 
        115                 120                 125             


Phe Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser 
    130                 135                 140                 


Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val 
145                 150                 155                 160 


Ser Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys 
                165                 170                 175     


Asn Leu Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile 
            180                 185                 190         


Tyr Ser Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly 
        195                 200                 205             


Phe Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile 
    210                 215                 220                 


Thr Arg Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro 
225                 230                 235                 240 


Gly Asp Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val 
                245                 250                 255     


Gly Tyr Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly 
            260                 265                 270         


Thr Ile Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr 
        275                 280                 285             


Lys Cys Thr Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr 
    290                 295                 300                 


Ser Asn Phe Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn 
305                 310                 315                 320 


Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe 
                325                 330                 335     


Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala 
            340                 345                 350         


Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys 
        355                 360                 365             


Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val 
    370                 375                 380                 


Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala 
385                 390                 395                 400 


Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp 
                405                 410                 415     


Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser 
            420                 425                 430         


Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser 
        435                 440                 445             


Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala 
    450                 455                 460                 


Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro 
465                 470                 475                 480 


Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro 
                485                 490                 495     


Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr 
            500                 505                 510         


Val Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val 
        515                 520                 525             


Asn Phe Asn Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser 
    530                 535                 540                 


Asn Lys Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp 
545                 550                 555                 560 


Thr Thr Asp Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile 
                565                 570                 575     


Thr Pro Cys Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn 
            580                 585                 590         


Thr Ser Asn Gln Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu 
        595                 600                 605             


Val Pro Val Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val 
    610                 615                 620                 


Tyr Ser Thr Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile 
625                 630                 635                 640 


Gly Ala Glu His Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly 
                645                 650                 655     


Ala Gly Ile Cys Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro Gly Ser 
            660                 665                 670         


Ala Ser Ser Val Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu 
        675                 680                 685             


Gly Ala Glu Asn Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro 
    690                 695                 700                 


Thr Asn Phe Thr Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met 
705                 710                 715                 720 


Thr Lys Thr Ser Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr 
                725                 730                 735     


Glu Cys Ser Asn Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu 
            740                 745                 750         


Asn Arg Ala Leu Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln 
        755                 760                 765             


Glu Val Phe Ala Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys 
    770                 775                 780                 


Asp Phe Gly Gly Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys 
785                 790                 795                 800 


Pro Ser Lys Arg Ser Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr 
                805                 810                 815     


Leu Ala Asp Ala Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp 
            820                 825                 830         


Ile Ala Ala Arg Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr 
        835                 840                 845             


Val Leu Pro Pro Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser 
    850                 855                 860                 


Ala Leu Leu Ala Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly 
865                 870                 875                 880 


Ala Ala Leu Gln Ile Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn 
                885                 890                 895     


Gly Ile Gly Val Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile 
            900                 905                 910         


Ala Asn Gln Phe Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser 
        915                 920                 925             


Ser Thr Ala Ser Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn 
    930                 935                 940                 


Ala Gln Ala Leu Asn Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly 
945                 950                 955                 960 


Ala Ile Ser Ser Val Leu Asn Asp Ile Leu Ser Arg Leu Asp Pro Pro 
                965                 970                 975     


Glu Ala Glu Val Gln Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser 
            980                 985                 990         


Leu Gln Thr Tyr Val Thr Gln Gln  Leu Ile Arg Ala Ala  Glu Ile Arg 
        995                 1000                 1005             


Ala Ser  Ala Asn Leu Ala Ala  Thr Lys Met Ser Glu  Cys Val Leu 
    1010                 1015                 1020             


Gly Gln  Ser Lys Arg Val Asp  Phe Cys Gly Lys Gly  Tyr His Leu 
    1025                 1030                 1035             


Met Ser  Phe Pro Gln Ser Ala  Pro His Gly Val Val  Phe Leu His 
    1040                 1045                 1050             


Val Thr  Tyr Val Pro Ala Gln  Glu Lys Asn Phe Thr  Thr Ala Pro 
    1055                 1060                 1065             


Ala Ile  Cys His Asp Gly Lys  Ala His Phe Pro Arg  Glu Gly Val 
    1070                 1075                 1080             


Phe Val  Ser Asn Gly Thr His  Trp Phe Val Thr Gln  Arg Asn Phe 
    1085                 1090                 1095             


Tyr Glu  Pro Gln Ile Ile Thr  Thr Asp Asn Thr Phe  Val Ser Gly 
    1100                 1105                 1110             


Asn Cys  Asp Val Val Ile Gly  Ile Val Asn Asn Thr  Val Tyr Asp 
    1115                 1120                 1125             


Pro Leu  Gln Ser Glu Leu Asp  Ser Ile Lys Glu Glu  Leu Asp Lys 
    1130                 1135                 1140             


Ile His  Lys Asn Gly Ser Gly  Gly Ser Gly Asp Ile  Ile Lys Leu 
    1145                 1150                 1155             


Leu Asn  Glu Gln Val Asn Lys  Glu Met Gln Ser Ser  Asn Leu Tyr 
    1160                 1165                 1170             


Met Ser  Met Ser Ser Trp Cys  Tyr Thr His Ser Leu  Asp Gly Ala 
    1175                 1180                 1185             


Gly Leu  Phe Leu Phe Asp His  Ala Ala Glu Glu Tyr  Glu His Ala 
    1190                 1195                 1200             


Lys Lys  Leu Ile Ile Phe Leu  Asn Glu Asn Asn Val  Pro Val Gln 
    1205                 1210                 1215             


Leu Thr  Ser Ile Ser Ala Pro  Glu His Lys Phe Glu  Gly Leu Thr 
    1220                 1225                 1230             


Gln Ile  Phe Gln Lys Ala Tyr  Glu His Glu Gln His  Ile Ser Glu 
    1235                 1240                 1245             


Ser Ile  Asn Asn Ile Val Asp  His Ala Ile Lys Ser  Lys Asp His 
    1250                 1255                 1260             


Ala Thr  Phe Asn Phe Leu Gln  Trp Tyr Val Ala Glu  Gln His Glu 
    1265                 1270                 1275             


Glu Glu  Val Leu Phe Lys Asp  Ile Leu Asp Lys Ile  Glu Leu Ile 
    1280                 1285                 1290             


Gly Asn  Glu Asn His Gly Leu  Tyr Leu Ala Asp Gln  Tyr Val Lys 
    1295                 1300                 1305             


Gly Ile  Ala Lys Ser Arg Lys  Ser Gly Ser 
    1310                 1315             


<210> 86
<211> 1318
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 86
Ser Ser Gln Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala 
1               5                   10                  15      


Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe 
            20                  25                  30          


Arg Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe 
        35                  40                  45              


Ser Asn Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly 
    50                  55                  60                  


Thr Lys Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr 
65                  70                  75                  80  


Phe Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly 
                85                  90                  95      


Thr Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala 
            100                 105                 110         


Thr Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro 
        115                 120                 125             


Phe Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser 
    130                 135                 140                 


Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val 
145                 150                 155                 160 


Ser Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys 
                165                 170                 175     


Asn Leu Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile 
            180                 185                 190         


Tyr Ser Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly 
        195                 200                 205             


Phe Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile 
    210                 215                 220                 


Thr Arg Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro 
225                 230                 235                 240 


Gly Asp Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val 
                245                 250                 255     


Gly Tyr Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly 
            260                 265                 270         


Thr Ile Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr 
        275                 280                 285             


Lys Cys Thr Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr 
    290                 295                 300                 


Ser Asn Phe Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn 
305                 310                 315                 320 


Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe 
                325                 330                 335     


Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala 
            340                 345                 350         


Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys 
        355                 360                 365             


Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val 
    370                 375                 380                 


Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala 
385                 390                 395                 400 


Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp 
                405                 410                 415     


Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser 
            420                 425                 430         


Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser 
        435                 440                 445             


Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala 
    450                 455                 460                 


Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro 
465                 470                 475                 480 


Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro 
                485                 490                 495     


Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr 
            500                 505                 510         


Val Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val 
        515                 520                 525             


Asn Phe Asn Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser 
    530                 535                 540                 


Asn Lys Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp 
545                 550                 555                 560 


Thr Thr Asp Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile 
                565                 570                 575     


Thr Pro Cys Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn 
            580                 585                 590         


Thr Ser Asn Gln Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu 
        595                 600                 605             


Val Pro Val Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val 
    610                 615                 620                 


Tyr Ser Thr Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile 
625                 630                 635                 640 


Gly Ala Glu His Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly 
                645                 650                 655     


Ala Gly Ile Cys Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro Gly Ser 
            660                 665                 670         


Ala Ser Ser Val Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu 
        675                 680                 685             


Gly Ala Glu Asn Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro 
    690                 695                 700                 


Thr Asn Phe Thr Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met 
705                 710                 715                 720 


Thr Lys Thr Ser Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr 
                725                 730                 735     


Glu Cys Ser Asn Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu 
            740                 745                 750         


Asn Arg Ala Leu Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln 
        755                 760                 765             


Glu Val Phe Ala Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys 
    770                 775                 780                 


Asp Phe Gly Gly Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys 
785                 790                 795                 800 


Pro Ser Lys Arg Ser Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr 
                805                 810                 815     


Leu Ala Asp Ala Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp 
            820                 825                 830         


Ile Ala Ala Arg Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr 
        835                 840                 845             


Val Leu Pro Pro Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser 
    850                 855                 860                 


Ala Leu Leu Ala Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly 
865                 870                 875                 880 


Ala Ala Leu Gln Ile Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn 
                885                 890                 895     


Gly Ile Gly Val Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile 
            900                 905                 910         


Ala Asn Gln Phe Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser 
        915                 920                 925             


Ser Thr Ala Ser Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn 
    930                 935                 940                 


Ala Gln Ala Leu Asn Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly 
945                 950                 955                 960 


Ala Ile Ser Ser Val Leu Asn Asp Ile Leu Ser Arg Leu Asp Pro Pro 
                965                 970                 975     


Glu Ala Glu Val Gln Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser 
            980                 985                 990         


Leu Gln Thr Tyr Val Thr Gln Gln  Leu Ile Arg Ala Ala  Glu Ile Arg 
        995                 1000                 1005             


Ala Ser  Ala Asn Leu Ala Ala  Thr Lys Met Ser Glu  Cys Val Leu 
    1010                 1015                 1020             


Gly Gln  Ser Lys Arg Val Asp  Phe Cys Gly Lys Gly  Tyr His Leu 
    1025                 1030                 1035             


Met Ser  Phe Pro Gln Ser Ala  Pro His Gly Val Val  Phe Leu His 
    1040                 1045                 1050             


Val Thr  Tyr Val Pro Ala Gln  Glu Lys Asn Phe Thr  Thr Ala Pro 
    1055                 1060                 1065             


Ala Ile  Cys His Asp Gly Lys  Ala His Phe Pro Arg  Glu Gly Val 
    1070                 1075                 1080             


Phe Val  Ser Asn Gly Thr His  Trp Phe Val Thr Gln  Arg Asn Phe 
    1085                 1090                 1095             


Tyr Glu  Pro Gln Ile Ile Thr  Thr Asp Asn Thr Phe  Val Ser Gly 
    1100                 1105                 1110             


Asn Cys  Asp Val Val Ile Gly  Ile Val Asn Asn Thr  Val Tyr Asp 
    1115                 1120                 1125             


Pro Leu  Gln Ser Glu Ile Asp  Ser Ile Lys Glu Glu  Ile Asp Lys 
    1130                 1135                 1140             


Ile His  Lys Asn Gly Ser Gly  Gly Ser Gly Asp Ile  Ile Lys Leu 
    1145                 1150                 1155             


Leu Asn  Glu Gln Val Asn Lys  Glu Met Gln Ser Ser  Asn Leu Tyr 
    1160                 1165                 1170             


Met Ser  Met Ser Ser Trp Cys  Tyr Thr His Ser Leu  Asp Gly Ala 
    1175                 1180                 1185             


Gly Leu  Phe Leu Phe Asp His  Ala Ala Glu Glu Tyr  Glu His Ala 
    1190                 1195                 1200             


Lys Lys  Leu Ile Ile Phe Leu  Asn Glu Asn Asn Val  Pro Val Gln 
    1205                 1210                 1215             


Leu Thr  Ser Ile Ser Ala Pro  Glu His Lys Phe Glu  Gly Leu Thr 
    1220                 1225                 1230             


Gln Ile  Phe Gln Lys Ala Tyr  Glu His Glu Gln His  Ile Ser Glu 
    1235                 1240                 1245             


Ser Ile  Asn Asn Ile Val Asp  His Ala Ile Lys Ser  Lys Asp His 
    1250                 1255                 1260             


Ala Thr  Phe Asn Phe Leu Gln  Trp Tyr Val Ala Glu  Gln His Glu 
    1265                 1270                 1275             


Glu Glu  Val Leu Phe Lys Asp  Ile Leu Asp Lys Ile  Glu Leu Ile 
    1280                 1285                 1290             


Gly Asn  Glu Asn His Gly Leu  Tyr Leu Ala Asp Gln  Tyr Val Lys 
    1295                 1300                 1305             


Gly Ile  Ala Lys Ser Arg Lys  Ser Gly Ser 
    1310                 1315             


<210> 87
<211> 1332
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 87
Ser Ser Gln Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala 
1               5                   10                  15      


Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe 
            20                  25                  30          


Arg Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe 
        35                  40                  45              


Ser Asn Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly 
    50                  55                  60                  


Thr Lys Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr 
65                  70                  75                  80  


Phe Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly 
                85                  90                  95      


Thr Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala 
            100                 105                 110         


Thr Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro 
        115                 120                 125             


Phe Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser 
    130                 135                 140                 


Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val 
145                 150                 155                 160 


Ser Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys 
                165                 170                 175     


Asn Leu Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile 
            180                 185                 190         


Tyr Ser Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly 
        195                 200                 205             


Phe Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile 
    210                 215                 220                 


Thr Arg Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro 
225                 230                 235                 240 


Gly Asp Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val 
                245                 250                 255     


Gly Tyr Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly 
            260                 265                 270         


Thr Ile Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr 
        275                 280                 285             


Lys Cys Thr Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr 
    290                 295                 300                 


Ser Asn Phe Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn 
305                 310                 315                 320 


Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe 
                325                 330                 335     


Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala 
            340                 345                 350         


Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys 
        355                 360                 365             


Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val 
    370                 375                 380                 


Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala 
385                 390                 395                 400 


Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp 
                405                 410                 415     


Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser 
            420                 425                 430         


Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser 
        435                 440                 445             


Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala 
    450                 455                 460                 


Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro 
465                 470                 475                 480 


Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro 
                485                 490                 495     


Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr 
            500                 505                 510         


Val Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val 
        515                 520                 525             


Asn Phe Asn Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser 
    530                 535                 540                 


Asn Lys Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp 
545                 550                 555                 560 


Thr Thr Asp Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile 
                565                 570                 575     


Thr Pro Cys Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn 
            580                 585                 590         


Thr Ser Asn Gln Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu 
        595                 600                 605             


Val Pro Val Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val 
    610                 615                 620                 


Tyr Ser Thr Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile 
625                 630                 635                 640 


Gly Ala Glu His Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly 
                645                 650                 655     


Ala Gly Ile Cys Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro Gly Ser 
            660                 665                 670         


Ala Ser Ser Val Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu 
        675                 680                 685             


Gly Ala Glu Asn Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro 
    690                 695                 700                 


Thr Asn Phe Thr Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met 
705                 710                 715                 720 


Thr Lys Thr Ser Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr 
                725                 730                 735     


Glu Cys Ser Asn Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu 
            740                 745                 750         


Asn Arg Ala Leu Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln 
        755                 760                 765             


Glu Val Phe Ala Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys 
    770                 775                 780                 


Asp Phe Gly Gly Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys 
785                 790                 795                 800 


Pro Ser Lys Arg Ser Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr 
                805                 810                 815     


Leu Ala Asp Ala Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp 
            820                 825                 830         


Ile Ala Ala Arg Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr 
        835                 840                 845             


Val Leu Pro Pro Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser 
    850                 855                 860                 


Ala Leu Leu Ala Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly 
865                 870                 875                 880 


Ala Ala Leu Gln Ile Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn 
                885                 890                 895     


Gly Ile Gly Val Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile 
            900                 905                 910         


Ala Asn Gln Phe Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser 
        915                 920                 925             


Ser Thr Ala Ser Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn 
    930                 935                 940                 


Ala Gln Ala Leu Asn Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly 
945                 950                 955                 960 


Ala Ile Ser Ser Val Leu Asn Asp Ile Leu Ser Arg Leu Asp Pro Pro 
                965                 970                 975     


Glu Ala Glu Val Gln Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser 
            980                 985                 990         


Leu Gln Thr Tyr Val Thr Gln Gln  Leu Ile Arg Ala Ala  Glu Ile Arg 
        995                 1000                 1005             


Ala Ser  Ala Asn Leu Ala Ala  Thr Lys Met Ser Glu  Cys Val Leu 
    1010                 1015                 1020             


Gly Gln  Ser Lys Arg Val Asp  Phe Cys Gly Lys Gly  Tyr His Leu 
    1025                 1030                 1035             


Met Ser  Phe Pro Gln Ser Ala  Pro His Gly Val Val  Phe Leu His 
    1040                 1045                 1050             


Val Thr  Tyr Val Pro Ala Gln  Glu Lys Asn Phe Thr  Thr Ala Pro 
    1055                 1060                 1065             


Ala Ile  Cys His Asp Gly Lys  Ala His Phe Pro Arg  Glu Gly Val 
    1070                 1075                 1080             


Phe Val  Ser Asn Gly Thr His  Trp Phe Val Thr Gln  Arg Asn Phe 
    1085                 1090                 1095             


Tyr Glu  Pro Gln Ile Ile Thr  Thr Asp Asn Thr Phe  Val Ser Gly 
    1100                 1105                 1110             


Asn Cys  Asp Val Val Ile Gly  Ile Val Asn Asn Thr  Val Tyr Asp 
    1115                 1120                 1125             


Pro Leu  Gln Ser Glu Leu Asp  Ser Ile Lys Glu Glu  Leu Asp Lys 
    1130                 1135                 1140             


Ile His  Lys Asn Leu Asp Ser  Ile Lys Glu Glu Leu  Asp Lys Ile 
    1145                 1150                 1155             


His Lys  Asn Gly Ser Gly Gly  Ser Gly Asp Ile Ile  Lys Leu Leu 
    1160                 1165                 1170             


Asn Glu  Gln Val Asn Lys Glu  Met Gln Ser Ser Asn  Leu Tyr Met 
    1175                 1180                 1185             


Ser Met  Ser Ser Trp Cys Tyr  Thr His Ser Leu Asp  Gly Ala Gly 
    1190                 1195                 1200             


Leu Phe  Leu Phe Asp His Ala  Ala Glu Glu Tyr Glu  His Ala Lys 
    1205                 1210                 1215             


Lys Leu  Ile Ile Phe Leu Asn  Glu Asn Asn Val Pro  Val Gln Leu 
    1220                 1225                 1230             


Thr Ser  Ile Ser Ala Pro Glu  His Lys Phe Glu Gly  Leu Thr Gln 
    1235                 1240                 1245             


Ile Phe  Gln Lys Ala Tyr Glu  His Glu Gln His Ile  Ser Glu Ser 
    1250                 1255                 1260             


Ile Asn  Asn Ile Val Asp His  Ala Ile Lys Ser Lys  Asp His Ala 
    1265                 1270                 1275             


Thr Phe  Asn Phe Leu Gln Trp  Tyr Val Ala Glu Gln  His Glu Glu 
    1280                 1285                 1290             


Glu Val  Leu Phe Lys Asp Ile  Leu Asp Lys Ile Glu  Leu Ile Gly 
    1295                 1300                 1305             


Asn Glu  Asn His Gly Leu Tyr  Leu Ala Asp Gln Tyr  Val Lys Gly 
    1310                 1315                 1320             


Ile Ala  Lys Ser Arg Lys Ser  Gly Ser 
    1325                 1330         


<210> 88
<211> 1332
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 88
Ser Ser Gln Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala 
1               5                   10                  15      


Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe 
            20                  25                  30          


Arg Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe 
        35                  40                  45              


Ser Asn Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly 
    50                  55                  60                  


Thr Lys Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr 
65                  70                  75                  80  


Phe Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly 
                85                  90                  95      


Thr Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala 
            100                 105                 110         


Thr Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro 
        115                 120                 125             


Phe Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser 
    130                 135                 140                 


Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val 
145                 150                 155                 160 


Ser Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys 
                165                 170                 175     


Asn Leu Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile 
            180                 185                 190         


Tyr Ser Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly 
        195                 200                 205             


Phe Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile 
    210                 215                 220                 


Thr Arg Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro 
225                 230                 235                 240 


Gly Asp Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val 
                245                 250                 255     


Gly Tyr Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly 
            260                 265                 270         


Thr Ile Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr 
        275                 280                 285             


Lys Cys Thr Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr 
    290                 295                 300                 


Ser Asn Phe Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn 
305                 310                 315                 320 


Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe 
                325                 330                 335     


Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala 
            340                 345                 350         


Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys 
        355                 360                 365             


Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val 
    370                 375                 380                 


Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala 
385                 390                 395                 400 


Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp 
                405                 410                 415     


Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser 
            420                 425                 430         


Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser 
        435                 440                 445             


Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala 
    450                 455                 460                 


Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro 
465                 470                 475                 480 


Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro 
                485                 490                 495     


Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr 
            500                 505                 510         


Val Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val 
        515                 520                 525             


Asn Phe Asn Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser 
    530                 535                 540                 


Asn Lys Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp 
545                 550                 555                 560 


Thr Thr Asp Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile 
                565                 570                 575     


Thr Pro Cys Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn 
            580                 585                 590         


Thr Ser Asn Gln Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu 
        595                 600                 605             


Val Pro Val Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val 
    610                 615                 620                 


Tyr Ser Thr Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile 
625                 630                 635                 640 


Gly Ala Glu His Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly 
                645                 650                 655     


Ala Gly Ile Cys Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro Gly Ser 
            660                 665                 670         


Ala Ser Ser Val Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu 
        675                 680                 685             


Gly Ala Glu Asn Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro 
    690                 695                 700                 


Thr Asn Phe Thr Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met 
705                 710                 715                 720 


Thr Lys Thr Ser Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr 
                725                 730                 735     


Glu Cys Ser Asn Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu 
            740                 745                 750         


Asn Arg Ala Leu Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln 
        755                 760                 765             


Glu Val Phe Ala Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys 
    770                 775                 780                 


Asp Phe Gly Gly Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys 
785                 790                 795                 800 


Pro Ser Lys Arg Ser Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr 
                805                 810                 815     


Leu Ala Asp Ala Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp 
            820                 825                 830         


Ile Ala Ala Arg Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr 
        835                 840                 845             


Val Leu Pro Pro Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser 
    850                 855                 860                 


Ala Leu Leu Ala Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly 
865                 870                 875                 880 


Ala Ala Leu Gln Ile Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn 
                885                 890                 895     


Gly Ile Gly Val Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile 
            900                 905                 910         


Ala Asn Gln Phe Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser 
        915                 920                 925             


Ser Thr Ala Ser Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn 
    930                 935                 940                 


Ala Gln Ala Leu Asn Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly 
945                 950                 955                 960 


Ala Ile Ser Ser Val Leu Asn Asp Ile Leu Ser Arg Leu Asp Pro Pro 
                965                 970                 975     


Glu Ala Glu Val Gln Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser 
            980                 985                 990         


Leu Gln Thr Tyr Val Thr Gln Gln  Leu Ile Arg Ala Ala  Glu Ile Arg 
        995                 1000                 1005             


Ala Ser  Ala Asn Leu Ala Ala  Thr Lys Met Ser Glu  Cys Val Leu 
    1010                 1015                 1020             


Gly Gln  Ser Lys Arg Val Asp  Phe Cys Gly Lys Gly  Tyr His Leu 
    1025                 1030                 1035             


Met Ser  Phe Pro Gln Ser Ala  Pro His Gly Val Val  Phe Leu His 
    1040                 1045                 1050             


Val Thr  Tyr Val Pro Ala Gln  Glu Lys Asn Phe Thr  Thr Ala Pro 
    1055                 1060                 1065             


Ala Ile  Cys His Asp Gly Lys  Ala His Phe Pro Arg  Glu Gly Val 
    1070                 1075                 1080             


Phe Val  Ser Asn Gly Thr His  Trp Phe Val Thr Gln  Arg Asn Phe 
    1085                 1090                 1095             


Tyr Glu  Pro Gln Ile Ile Thr  Thr Asp Asn Thr Phe  Val Ser Gly 
    1100                 1105                 1110             


Asn Cys  Asp Val Val Ile Gly  Ile Val Asn Asn Thr  Val Tyr Asp 
    1115                 1120                 1125             


Pro Leu  Gln Ser Glu Ile Asp  Ser Ile Lys Glu Glu  Ile Asp Lys 
    1130                 1135                 1140             


Ile His  Lys Asn Ile Asp Ser  Ile Lys Glu Glu Ile  Asp Lys Ile 
    1145                 1150                 1155             


His Lys  Asn Gly Ser Gly Gly  Ser Gly Asp Ile Ile  Lys Leu Leu 
    1160                 1165                 1170             


Asn Glu  Gln Val Asn Lys Glu  Met Gln Ser Ser Asn  Leu Tyr Met 
    1175                 1180                 1185             


Ser Met  Ser Ser Trp Cys Tyr  Thr His Ser Leu Asp  Gly Ala Gly 
    1190                 1195                 1200             


Leu Phe  Leu Phe Asp His Ala  Ala Glu Glu Tyr Glu  His Ala Lys 
    1205                 1210                 1215             


Lys Leu  Ile Ile Phe Leu Asn  Glu Asn Asn Val Pro  Val Gln Leu 
    1220                 1225                 1230             


Thr Ser  Ile Ser Ala Pro Glu  His Lys Phe Glu Gly  Leu Thr Gln 
    1235                 1240                 1245             


Ile Phe  Gln Lys Ala Tyr Glu  His Glu Gln His Ile  Ser Glu Ser 
    1250                 1255                 1260             


Ile Asn  Asn Ile Val Asp His  Ala Ile Lys Ser Lys  Asp His Ala 
    1265                 1270                 1275             


Thr Phe  Asn Phe Leu Gln Trp  Tyr Val Ala Glu Gln  His Glu Glu 
    1280                 1285                 1290             


Glu Val  Leu Phe Lys Asp Ile  Leu Asp Lys Ile Glu  Leu Ile Gly 
    1295                 1300                 1305             


Asn Glu  Asn His Gly Leu Tyr  Leu Ala Asp Gln Tyr  Val Lys Gly 
    1310                 1315                 1320             


Ile Ala  Lys Ser Arg Lys Ser  Gly Ser 
    1325                 1330         


<210> 89
<211> 1349
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 89
Ser Ser Gln Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala 
1               5                   10                  15      


Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe 
            20                  25                  30          


Arg Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe 
        35                  40                  45              


Ser Asn Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly 
    50                  55                  60                  


Thr Lys Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr 
65                  70                  75                  80  


Phe Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly 
                85                  90                  95      


Thr Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala 
            100                 105                 110         


Thr Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro 
        115                 120                 125             


Phe Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser 
    130                 135                 140                 


Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val 
145                 150                 155                 160 


Ser Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys 
                165                 170                 175     


Asn Leu Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile 
            180                 185                 190         


Tyr Ser Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly 
        195                 200                 205             


Phe Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile 
    210                 215                 220                 


Thr Arg Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro 
225                 230                 235                 240 


Gly Asp Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val 
                245                 250                 255     


Gly Tyr Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly 
            260                 265                 270         


Thr Ile Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr 
        275                 280                 285             


Lys Cys Thr Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr 
    290                 295                 300                 


Ser Asn Phe Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn 
305                 310                 315                 320 


Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe 
                325                 330                 335     


Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala 
            340                 345                 350         


Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys 
        355                 360                 365             


Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val 
    370                 375                 380                 


Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala 
385                 390                 395                 400 


Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp 
                405                 410                 415     


Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser 
            420                 425                 430         


Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser 
        435                 440                 445             


Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala 
    450                 455                 460                 


Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro 
465                 470                 475                 480 


Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro 
                485                 490                 495     


Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr 
            500                 505                 510         


Val Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val 
        515                 520                 525             


Asn Phe Asn Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser 
    530                 535                 540                 


Asn Lys Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp 
545                 550                 555                 560 


Thr Thr Asp Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile 
                565                 570                 575     


Thr Pro Cys Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn 
            580                 585                 590         


Thr Ser Asn Gln Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu 
        595                 600                 605             


Val Pro Val Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val 
    610                 615                 620                 


Tyr Ser Thr Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile 
625                 630                 635                 640 


Gly Ala Glu His Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly 
                645                 650                 655     


Ala Gly Ile Cys Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro Gly Ser 
            660                 665                 670         


Ala Ser Ser Val Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu 
        675                 680                 685             


Gly Ala Glu Asn Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro 
    690                 695                 700                 


Thr Asn Phe Thr Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met 
705                 710                 715                 720 


Thr Lys Thr Ser Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr 
                725                 730                 735     


Glu Cys Ser Asn Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu 
            740                 745                 750         


Asn Arg Ala Leu Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln 
        755                 760                 765             


Glu Val Phe Ala Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys 
    770                 775                 780                 


Asp Phe Gly Gly Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys 
785                 790                 795                 800 


Pro Ser Lys Arg Ser Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr 
                805                 810                 815     


Leu Ala Asp Ala Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp 
            820                 825                 830         


Ile Ala Ala Arg Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr 
        835                 840                 845             


Val Leu Pro Pro Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser 
    850                 855                 860                 


Ala Leu Leu Ala Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly 
865                 870                 875                 880 


Ala Ala Leu Gln Ile Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn 
                885                 890                 895     


Gly Ile Gly Val Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile 
            900                 905                 910         


Ala Asn Gln Phe Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser 
        915                 920                 925             


Ser Thr Ala Ser Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn 
    930                 935                 940                 


Ala Gln Ala Leu Asn Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly 
945                 950                 955                 960 


Ala Ile Ser Ser Val Leu Asn Asp Ile Leu Ser Arg Leu Asp Pro Pro 
                965                 970                 975     


Glu Ala Glu Val Gln Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser 
            980                 985                 990         


Leu Gln Thr Tyr Val Thr Gln Gln  Leu Ile Arg Ala Ala  Glu Ile Arg 
        995                 1000                 1005             


Ala Ser  Ala Asn Leu Ala Ala  Thr Lys Met Ser Glu  Cys Val Leu 
    1010                 1015                 1020             


Gly Gln  Ser Lys Arg Val Asp  Phe Cys Gly Lys Gly  Tyr His Leu 
    1025                 1030                 1035             


Met Ser  Phe Pro Gln Ser Ala  Pro His Gly Val Val  Phe Leu His 
    1040                 1045                 1050             


Val Thr  Tyr Val Pro Ala Gln  Glu Lys Asn Phe Thr  Thr Ala Pro 
    1055                 1060                 1065             


Ala Ile  Cys His Asp Gly Lys  Ala His Phe Pro Arg  Glu Gly Val 
    1070                 1075                 1080             


Phe Val  Ser Asn Gly Thr His  Trp Phe Val Thr Gln  Arg Asn Phe 
    1085                 1090                 1095             


Tyr Glu  Pro Gln Ile Ile Thr  Thr Asp Asn Thr Phe  Val Ser Gly 
    1100                 1105                 1110             


Asn Cys  Asp Val Val Ile Gly  Ile Val Asn Asn Thr  Val Tyr Asp 
    1115                 1120                 1125             


Pro Leu  Gln Ser Glu Leu Asp  Ser Ile Lys Glu Glu  Leu Asp Lys 
    1130                 1135                 1140             


Ile His  Lys Asn Met Lys Gln  Ile Glu Asp Lys Ile  Glu Glu Ile 
    1145                 1150                 1155             


Leu Ser  Lys Ile Tyr His Ile  Glu Asn Glu Ile Ala  Arg Ile Lys 
    1160                 1165                 1170             


Lys Leu  Ile Gly Arg Gly Ser  Gly Gly Ser Gly Asp  Ile Ile Lys 
    1175                 1180                 1185             


Leu Leu  Asn Glu Gln Val Asn  Lys Glu Met Gln Ser  Ser Asn Leu 
    1190                 1195                 1200             


Tyr Met  Ser Met Ser Ser Trp  Cys Tyr Thr His Ser  Leu Asp Gly 
    1205                 1210                 1215             


Ala Gly  Leu Phe Leu Phe Asp  His Ala Ala Glu Glu  Tyr Glu His 
    1220                 1225                 1230             


Ala Lys  Lys Leu Ile Ile Phe  Leu Asn Glu Asn Asn  Val Pro Val 
    1235                 1240                 1245             


Gln Leu  Thr Ser Ile Ser Ala  Pro Glu His Lys Phe  Glu Gly Leu 
    1250                 1255                 1260             


Thr Gln  Ile Phe Gln Lys Ala  Tyr Glu His Glu Gln  His Ile Ser 
    1265                 1270                 1275             


Glu Ser  Ile Asn Asn Ile Val  Asp His Ala Ile Lys  Ser Lys Asp 
    1280                 1285                 1290             


His Ala  Thr Phe Asn Phe Leu  Gln Trp Tyr Val Ala  Glu Gln His 
    1295                 1300                 1305             


Glu Glu  Glu Val Leu Phe Lys  Asp Ile Leu Asp Lys  Ile Glu Leu 
    1310                 1315                 1320             


Ile Gly  Asn Glu Asn His Gly  Leu Tyr Leu Ala Asp  Gln Tyr Val 
    1325                 1330                 1335             


Lys Gly  Ile Ala Lys Ser Arg  Lys Ser Gly Ser 
    1340                 1345                 


<210> 90
<211> 495
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 90
His His His His His His His His Gly Pro Leu Glu Val Leu Phe Gln 
1               5                   10                  15      


Gly Pro Ser Ser Gln Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro 
            20                  25                  30          


Pro Ala Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys 
        35                  40                  45              


Val Phe Arg Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro 
    50                  55                  60                  


Phe Phe Ser Asn Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr 
65                  70                  75                  80  


Asn Gly Thr Lys Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly 
                85                  90                  95      


Val Tyr Phe Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile 
            100                 105                 110         


Phe Gly Thr Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn 
        115                 120                 125             


Asn Ala Thr Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn 
    130                 135                 140                 


Asp Pro Phe Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met 
145                 150                 155                 160 


Glu Ser Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu 
                165                 170                 175     


Tyr Val Ser Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn 
            180                 185                 190         


Phe Lys Asn Leu Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe 
        195                 200                 205             


Lys Ile Tyr Ser Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro 
    210                 215                 220                 


Gln Gly Phe Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile 
225                 230                 235                 240 


Asn Ile Thr Arg Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu 
                245                 250                 255     


Thr Pro Gly Asp Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr 
            260                 265                 270         


Tyr Val Gly Tyr Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu 
        275                 280                 285             


Asn Gly Thr Ile Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser 
    290                 295                 300                 


Glu Thr Lys Cys Thr Leu Lys Ser Phe Thr Gly Ser Gly Gly Gly Gly 
305                 310                 315                 320 


Glu Ser Gln Val Arg Gln Gln Phe Ser Lys Asp Ile Glu Lys Leu Leu 
                325                 330                 335     


Asn Glu Gln Val Asn Lys Glu Met Gln Ser Ser Asn Leu Tyr Met Ser 
            340                 345                 350         


Met Ser Ser Trp Cys Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe 
        355                 360                 365             


Leu Phe Asp His Ala Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile 
    370                 375                 380                 


Ile Phe Leu Asn Glu Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser 
385                 390                 395                 400 


Ala Pro Glu His Lys Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala 
                405                 410                 415     


Tyr Glu His Glu Gln His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp 
            420                 425                 430         


His Ala Ile Lys Ser Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp 
        435                 440                 445             


Tyr Val Ala Glu Gln His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu 
    450                 455                 460                 


Asp Lys Ile Glu Leu Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala 
465                 470                 475                 480 


Asp Gln Tyr Val Lys Gly Ile Ala Lys Ser Arg Lys Ser Gly Ser 
                485                 490                 495 


<210> 91
<211> 491
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 91
His His His His His His His His Gly Pro Leu Glu Val Leu Phe Gln 
1               5                   10                  15      


Gly Pro Ser Ser Gln Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro 
            20                  25                  30          


Pro Ala Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys 
        35                  40                  45              


Val Phe Arg Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro 
    50                  55                  60                  


Phe Phe Ser Asn Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr 
65                  70                  75                  80  


Asn Gly Thr Lys Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly 
                85                  90                  95      


Val Tyr Phe Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile 
            100                 105                 110         


Phe Gly Thr Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn 
        115                 120                 125             


Asn Ala Thr Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn 
    130                 135                 140                 


Asp Pro Phe Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met 
145                 150                 155                 160 


Glu Ser Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu 
                165                 170                 175     


Tyr Val Ser Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn 
            180                 185                 190         


Phe Lys Asn Leu Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe 
        195                 200                 205             


Lys Ile Tyr Ser Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro 
    210                 215                 220                 


Gln Gly Phe Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile 
225                 230                 235                 240 


Asn Ile Thr Arg Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu 
                245                 250                 255     


Thr Pro Gly Asp Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr 
            260                 265                 270         


Tyr Val Gly Tyr Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu 
        275                 280                 285             


Asn Gly Thr Ile Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Lys Ser 
    290                 295                 300                 


Glu Thr Lys Cys Thr Asp Gly Ser Gly Gly Gly Gly Glu Ser Gln Val 
305                 310                 315                 320 


Arg Gln Gln Phe Ser Lys Asp Ile Glu Lys Leu Leu Asn Glu Gln Val 
                325                 330                 335     


Asn Lys Glu Met Gln Ser Ser Asn Leu Tyr Met Ser Met Ser Ser Trp 
            340                 345                 350         


Cys Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp His 
        355                 360                 365             


Ala Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe Leu Asn 
    370                 375                 380                 


Glu Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro Glu His 
385                 390                 395                 400 


Lys Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu His Glu 
                405                 410                 415     


Gln His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala Ile Lys 
            420                 425                 430         


Ser Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala Glu 
        435                 440                 445             


Gln His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys Ile Glu 
    450                 455                 460                 


Leu Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr Val 
465                 470                 475                 480 


Lys Gly Ile Ala Lys Ser Arg Lys Ser Gly Ser 
                485                 490     


<210> 92
<211> 495
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 92
His His His His His His His His Gly Pro Leu Glu Val Leu Phe Gln 
1               5                   10                  15      


Gly Pro Ser Ser Gln Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro 
            20                  25                  30          


Pro Ala Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys 
        35                  40                  45              


Val Phe Arg Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro 
    50                  55                  60                  


Phe Phe Ser Asn Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr 
65                  70                  75                  80  


Asn Gly Thr Lys Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly 
                85                  90                  95      


Val Tyr Phe Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile 
            100                 105                 110         


Phe Gly Thr Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn 
        115                 120                 125             


Asn Ala Thr Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn 
    130                 135                 140                 


Asp Pro Phe Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met 
145                 150                 155                 160 


Glu Ser Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu 
                165                 170                 175     


Tyr Val Ser Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn 
            180                 185                 190         


Phe Lys Asn Leu Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe 
        195                 200                 205             


Lys Ile Tyr Ser Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro 
    210                 215                 220                 


Gln Gly Phe Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile 
225                 230                 235                 240 


Asn Ile Thr Arg Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu 
                245                 250                 255     


Thr Pro Gly Asp Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr 
            260                 265                 270         


Tyr Val Gly Tyr Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu 
        275                 280                 285             


Asn Gly Thr Ile Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Lys Ser 
    290                 295                 300                 


Glu Thr Lys Cys Thr Asp Lys Ser Phe Thr Gly Ser Gly Gly Gly Gly 
305                 310                 315                 320 


Glu Ser Gln Val Arg Gln Gln Phe Ser Lys Asp Ile Glu Lys Leu Leu 
                325                 330                 335     


Asn Glu Gln Val Asn Lys Glu Met Gln Ser Ser Asn Leu Tyr Met Ser 
            340                 345                 350         


Met Ser Ser Trp Cys Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe 
        355                 360                 365             


Leu Phe Asp His Ala Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile 
    370                 375                 380                 


Ile Phe Leu Asn Glu Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser 
385                 390                 395                 400 


Ala Pro Glu His Lys Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala 
                405                 410                 415     


Tyr Glu His Glu Gln His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp 
            420                 425                 430         


His Ala Ile Lys Ser Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp 
        435                 440                 445             


Tyr Val Ala Glu Gln His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu 
    450                 455                 460                 


Asp Lys Ile Glu Leu Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala 
465                 470                 475                 480 


Asp Gln Tyr Val Lys Gly Ile Ala Lys Ser Arg Lys Ser Gly Ser 
                485                 490                 495 


<210> 93
<211> 491
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 93
His His His His His His His His Gly Pro Leu Glu Val Leu Phe Gln 
1               5                   10                  15      


Gly Pro Ser Ser Gln Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro 
            20                  25                  30          


Pro Ala Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys 
        35                  40                  45              


Val Phe Arg Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro 
    50                  55                  60                  


Phe Phe Ser Asn Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr 
65                  70                  75                  80  


Asn Gly Thr Lys Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly 
                85                  90                  95      


Val Tyr Phe Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile 
            100                 105                 110         


Phe Gly Thr Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn 
        115                 120                 125             


Asn Ala Thr Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn 
    130                 135                 140                 


Asp Pro Phe Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met 
145                 150                 155                 160 


Glu Ser Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu 
                165                 170                 175     


Tyr Val Ser Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn 
            180                 185                 190         


Phe Lys Asn Leu Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe 
        195                 200                 205             


Lys Ile Tyr Ser Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro 
    210                 215                 220                 


Gln Gly Phe Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile 
225                 230                 235                 240 


Asn Ile Thr Arg Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu 
                245                 250                 255     


Thr Pro Gly Asp Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr 
            260                 265                 270         


Tyr Val Gly Tyr Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu 
        275                 280                 285             


Asn Gly Thr Ile Thr Asp Ala Val Asp Cys Gly Asn Asp Thr Leu Ser 
    290                 295                 300                 


Glu Thr Lys Cys Thr Leu Gly Ser Gly Gly Gly Gly Glu Ser Gln Val 
305                 310                 315                 320 


Arg Gln Gln Phe Ser Lys Asp Ile Glu Lys Leu Leu Asn Glu Gln Val 
                325                 330                 335     


Asn Lys Glu Met Gln Ser Ser Asn Leu Tyr Met Ser Met Ser Ser Trp 
            340                 345                 350         


Cys Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp His 
        355                 360                 365             


Ala Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe Leu Asn 
    370                 375                 380                 


Glu Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro Glu His 
385                 390                 395                 400 


Lys Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu His Glu 
                405                 410                 415     


Gln His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala Ile Lys 
            420                 425                 430         


Ser Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala Glu 
        435                 440                 445             


Gln His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys Ile Glu 
    450                 455                 460                 


Leu Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr Val 
465                 470                 475                 480 


Lys Gly Ile Ala Lys Ser Arg Lys Ser Gly Ser 
                485                 490     


<210> 94
<211> 491
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 94
His His His His His His His His Gly Pro Leu Glu Val Leu Phe Gln 
1               5                   10                  15      


Gly Pro Ser Ser Gln Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro 
            20                  25                  30          


Pro Ala Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys 
        35                  40                  45              


Val Phe Arg Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro 
    50                  55                  60                  


Phe Thr Ser Asn Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr 
65                  70                  75                  80  


Asn Gly Thr Lys Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly 
                85                  90                  95      


Val Tyr Phe Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile 
            100                 105                 110         


Phe Gly Thr Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn 
        115                 120                 125             


Asn Ala Thr Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn 
    130                 135                 140                 


Asp Pro Phe Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met 
145                 150                 155                 160 


Glu Ser Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu 
                165                 170                 175     


Tyr Val Ser Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn 
            180                 185                 190         


Phe Lys Asn Leu Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe 
        195                 200                 205             


Lys Ile Tyr Ser Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro 
    210                 215                 220                 


Gln Gly Phe Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile 
225                 230                 235                 240 


Asn Ile Thr Arg Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu 
                245                 250                 255     


Thr Pro Gly Asp Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr 
            260                 265                 270         


Tyr Val Gly Tyr Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu 
        275                 280                 285             


Asn Gly Thr Ile Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser 
    290                 295                 300                 


Glu Thr Lys Cys Thr Leu Gly Ser Gly Gly Gly Gly Glu Ser Gln Val 
305                 310                 315                 320 


Arg Gln Gln Phe Ser Lys Asp Ile Glu Lys Leu Leu Asn Glu Gln Val 
                325                 330                 335     


Asn Lys Glu Met Gln Ser Ser Asn Leu Tyr Met Ser Met Ser Ser Trp 
            340                 345                 350         


Cys Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp His 
        355                 360                 365             


Ala Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe Leu Asn 
    370                 375                 380                 


Glu Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro Glu His 
385                 390                 395                 400 


Lys Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu His Glu 
                405                 410                 415     


Gln His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala Ile Lys 
            420                 425                 430         


Ser Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala Glu 
        435                 440                 445             


Gln His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys Ile Glu 
    450                 455                 460                 


Leu Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr Val 
465                 470                 475                 480 


Lys Gly Ile Ala Lys Ser Arg Lys Ser Gly Ser 
                485                 490     


<210> 95
<211> 491
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 95
His His His His His His His His Gly Pro Leu Glu Val Leu Phe Gln 
1               5                   10                  15      


Gly Pro Ser Ser Gln Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro 
            20                  25                  30          


Pro Ala Thr Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys 
        35                  40                  45              


Val Phe Arg Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro 
    50                  55                  60                  


Phe Phe Ser Asn Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr 
65                  70                  75                  80  


Asn Gly Thr Lys Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly 
                85                  90                  95      


Val Tyr Phe Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile 
            100                 105                 110         


Phe Gly Thr Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn 
        115                 120                 125             


Asn Ala Thr Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn 
    130                 135                 140                 


Asp Pro Phe Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met 
145                 150                 155                 160 


Glu Ser Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu 
                165                 170                 175     


Tyr Val Ser Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn 
            180                 185                 190         


Phe Lys Asn Leu Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe 
        195                 200                 205             


Lys Ile Tyr Ser Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro 
    210                 215                 220                 


Gln Gly Phe Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile 
225                 230                 235                 240 


Asn Ile Thr Arg Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu 
                245                 250                 255     


Thr Pro Gly Asp Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr 
            260                 265                 270         


Tyr Val Gly Tyr Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu 
        275                 280                 285             


Asn Gly Thr Ile Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser 
    290                 295                 300                 


Glu Thr Lys Cys Thr Leu Gly Ser Gly Gly Gly Gly Glu Ser Gln Val 
305                 310                 315                 320 


Arg Gln Gln Phe Ser Lys Asp Ile Glu Lys Leu Leu Asn Glu Gln Val 
                325                 330                 335     


Asn Lys Glu Met Gln Ser Ser Asn Leu Tyr Met Ser Met Ser Ser Trp 
            340                 345                 350         


Cys Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp His 
        355                 360                 365             


Ala Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe Leu Asn 
    370                 375                 380                 


Glu Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro Glu His 
385                 390                 395                 400 


Lys Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu His Glu 
                405                 410                 415     


Gln His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala Ile Lys 
            420                 425                 430         


Ser Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala Glu 
        435                 440                 445             


Gln His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys Ile Glu 
    450                 455                 460                 


Leu Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr Val 
465                 470                 475                 480 


Lys Gly Ile Ala Lys Ser Arg Lys Ser Gly Ser 
                485                 490     


<210> 96
<211> 491
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 96
His His His His His His His His Gly Pro Leu Glu Val Leu Phe Gln 
1               5                   10                  15      


Gly Pro Ser Ser Gln Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro 
            20                  25                  30          


Pro Ala Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys 
        35                  40                  45              


Val Phe Arg Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro 
    50                  55                  60                  


Phe Phe Ser Asn Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr 
65                  70                  75                  80  


Asn Gly Thr Lys Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly 
                85                  90                  95      


Val Tyr Phe Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile 
            100                 105                 110         


Phe Gly Thr Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn 
        115                 120                 125             


Asn Ala Thr Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn 
    130                 135                 140                 


Asp Pro Phe Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met 
145                 150                 155                 160 


Glu Ser Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu 
                165                 170                 175     


Tyr Val Ser Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn 
            180                 185                 190         


Phe Lys Asn Leu Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Ala Phe 
        195                 200                 205             


Lys Ile Tyr Ser Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro 
    210                 215                 220                 


Gln Gly Phe Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile 
225                 230                 235                 240 


Asn Ile Thr Arg Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu 
                245                 250                 255     


Thr Pro Gly Asp Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr 
            260                 265                 270         


Tyr Val Gly Tyr Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu 
        275                 280                 285             


Asn Gly Thr Ile Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser 
    290                 295                 300                 


Glu Thr Lys Cys Thr Leu Gly Ser Gly Gly Gly Gly Glu Ser Gln Val 
305                 310                 315                 320 


Arg Gln Gln Phe Ser Lys Asp Ile Glu Lys Leu Leu Asn Glu Gln Val 
                325                 330                 335     


Asn Lys Glu Met Gln Ser Ser Asn Leu Tyr Met Ser Met Ser Ser Trp 
            340                 345                 350         


Cys Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp His 
        355                 360                 365             


Ala Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe Leu Asn 
    370                 375                 380                 


Glu Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro Glu His 
385                 390                 395                 400 


Lys Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu His Glu 
                405                 410                 415     


Gln His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala Ile Lys 
            420                 425                 430         


Ser Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala Glu 
        435                 440                 445             


Gln His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys Ile Glu 
    450                 455                 460                 


Leu Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr Val 
465                 470                 475                 480 


Lys Gly Ile Ala Lys Ser Arg Lys Ser Gly Ser 
                485                 490     


<210> 97
<211> 491
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 97
His His His His His His His His Gly Pro Leu Glu Val Leu Phe Gln 
1               5                   10                  15      


Gly Pro Ser Ser Gln Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro 
            20                  25                  30          


Pro Ala Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys 
        35                  40                  45              


Val Phe Arg Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro 
    50                  55                  60                  


Phe Phe Ser Asn Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr 
65                  70                  75                  80  


Asn Gly Thr Lys Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly 
                85                  90                  95      


Val Tyr Phe Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile 
            100                 105                 110         


Phe Gly Thr Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn 
        115                 120                 125             


Asn Ala Thr Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn 
    130                 135                 140                 


Asp Pro Phe Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met 
145                 150                 155                 160 


Glu Ser Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu 
                165                 170                 175     


Tyr Val Ser Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn 
            180                 185                 190         


Phe Lys Asn Leu Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Asn Phe 
        195                 200                 205             


Thr Ile Tyr Ser Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro 
    210                 215                 220                 


Gln Gly Phe Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile 
225                 230                 235                 240 


Asn Ile Thr Arg Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu 
                245                 250                 255     


Thr Pro Gly Asp Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr 
            260                 265                 270         


Tyr Val Gly Tyr Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu 
        275                 280                 285             


Asn Gly Thr Ile Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser 
    290                 295                 300                 


Glu Thr Lys Cys Thr Leu Gly Ser Gly Gly Gly Gly Glu Ser Gln Val 
305                 310                 315                 320 


Arg Gln Gln Phe Ser Lys Asp Ile Glu Lys Leu Leu Asn Glu Gln Val 
                325                 330                 335     


Asn Lys Glu Met Gln Ser Ser Asn Leu Tyr Met Ser Met Ser Ser Trp 
            340                 345                 350         


Cys Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp His 
        355                 360                 365             


Ala Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe Leu Asn 
    370                 375                 380                 


Glu Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro Glu His 
385                 390                 395                 400 


Lys Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu His Glu 
                405                 410                 415     


Gln His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala Ile Lys 
            420                 425                 430         


Ser Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala Glu 
        435                 440                 445             


Gln His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys Ile Glu 
    450                 455                 460                 


Leu Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr Val 
465                 470                 475                 480 


Lys Gly Ile Ala Lys Ser Arg Lys Ser Gly Ser 
                485                 490     


<210> 98
<211> 491
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 98
His His His His His His His His Gly Pro Leu Glu Val Leu Phe Gln 
1               5                   10                  15      


Gly Pro Ser Ser Gln Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro 
            20                  25                  30          


Pro Ala Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr Thr Pro Asp Lys 
        35                  40                  45              


Val Phe Arg Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro 
    50                  55                  60                  


Phe Phe Ser Asn Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr 
65                  70                  75                  80  


Asn Gly Thr Lys Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly 
                85                  90                  95      


Val Tyr Phe Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile 
            100                 105                 110         


Phe Gly Thr Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn 
        115                 120                 125             


Asn Ala Thr Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn 
    130                 135                 140                 


Asp Pro Phe Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met 
145                 150                 155                 160 


Glu Ser Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu 
                165                 170                 175     


Tyr Val Ser Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn 
            180                 185                 190         


Phe Lys Asn Leu Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe 
        195                 200                 205             


Lys Ile Tyr Ser Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro 
    210                 215                 220                 


Gln Gly Phe Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile 
225                 230                 235                 240 


Asn Ile Thr Arg Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu 
                245                 250                 255     


Thr Pro Gly Asp Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr 
            260                 265                 270         


Tyr Val Gly Tyr Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu 
        275                 280                 285             


Asn Gly Thr Ile Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser 
    290                 295                 300                 


Glu Thr Lys Cys Thr Leu Gly Ser Gly Gly Gly Gly Glu Ser Gln Val 
305                 310                 315                 320 


Arg Gln Gln Phe Ser Lys Asp Ile Glu Lys Leu Leu Asn Glu Gln Val 
                325                 330                 335     


Asn Lys Glu Met Gln Ser Ser Asn Leu Tyr Met Ser Met Ser Ser Trp 
            340                 345                 350         


Cys Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp His 
        355                 360                 365             


Ala Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe Leu Asn 
    370                 375                 380                 


Glu Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro Glu His 
385                 390                 395                 400 


Lys Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu His Glu 
                405                 410                 415     


Gln His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala Ile Lys 
            420                 425                 430         


Ser Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala Glu 
        435                 440                 445             


Gln His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys Ile Glu 
    450                 455                 460                 


Leu Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr Val 
465                 470                 475                 480 


Lys Gly Ile Ala Lys Ser Arg Lys Ser Gly Ser 
                485                 490     


<210> 99
<211> 491
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 99
His His His His His His His His Gly Pro Leu Glu Val Leu Phe Gln 
1               5                   10                  15      


Gly Pro Ser Ser Gln Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro 
            20                  25                  30          


Pro Ala Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys 
        35                  40                  45              


Thr Ala Arg Ser Ser Thr Leu His Ser Thr Gln Asp Leu Phe Leu Pro 
    50                  55                  60                  


Phe Phe Ser Asn Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr 
65                  70                  75                  80  


Asn Gly Thr Lys Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly 
                85                  90                  95      


Val Tyr Phe Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile 
            100                 105                 110         


Phe Gly Thr Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn 
        115                 120                 125             


Asn Ala Thr Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn 
    130                 135                 140                 


Asp Pro Phe Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met 
145                 150                 155                 160 


Glu Ser Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu 
                165                 170                 175     


Tyr Val Ser Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn 
            180                 185                 190         


Phe Lys Asn Leu Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe 
        195                 200                 205             


Lys Ile Tyr Ser Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro 
    210                 215                 220                 


Gln Gly Phe Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile 
225                 230                 235                 240 


Asn Ile Thr Arg Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu 
                245                 250                 255     


Thr Pro Gly Asp Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr 
            260                 265                 270         


Tyr Val Gly Tyr Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu 
        275                 280                 285             


Asn Gly Thr Ile Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser 
    290                 295                 300                 


Glu Thr Lys Cys Thr Leu Gly Ser Gly Gly Gly Gly Glu Ser Gln Val 
305                 310                 315                 320 


Arg Gln Gln Phe Ser Lys Asp Ile Glu Lys Leu Leu Asn Glu Gln Val 
                325                 330                 335     


Asn Lys Glu Met Gln Ser Ser Asn Leu Tyr Met Ser Met Ser Ser Trp 
            340                 345                 350         


Cys Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp His 
        355                 360                 365             


Ala Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe Leu Asn 
    370                 375                 380                 


Glu Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro Glu His 
385                 390                 395                 400 


Lys Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu His Glu 
                405                 410                 415     


Gln His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala Ile Lys 
            420                 425                 430         


Ser Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala Glu 
        435                 440                 445             


Gln His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys Ile Glu 
    450                 455                 460                 


Leu Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr Val 
465                 470                 475                 480 


Lys Gly Ile Ala Lys Ser Arg Lys Ser Gly Ser 
                485                 490     


<210> 100
<211> 491
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 100
His His His His His His His His Gly Pro Leu Glu Val Leu Phe Gln 
1               5                   10                  15      


Gly Pro Ser Ser Gln Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro 
            20                  25                  30          


Pro Ala Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys 
        35                  40                  45              


Val Phe Arg Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro 
    50                  55                  60                  


Phe Phe Ser Asn Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr 
65                  70                  75                  80  


Asn Gly Thr Lys Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly 
                85                  90                  95      


Val Tyr Phe Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile 
            100                 105                 110         


Phe Gly Thr Thr Leu Asp Ser Lys Thr Gln Ser Leu Asn Ile Thr Asn 
        115                 120                 125             


Asn Ala Thr Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn 
    130                 135                 140                 


Asp Pro Phe Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met 
145                 150                 155                 160 


Glu Ser Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu 
                165                 170                 175     


Tyr Val Ser Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn 
            180                 185                 190         


Phe Lys Asn Leu Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe 
        195                 200                 205             


Lys Ile Tyr Ser Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro 
    210                 215                 220                 


Gln Gly Phe Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile 
225                 230                 235                 240 


Asn Ile Thr Arg Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu 
                245                 250                 255     


Thr Pro Gly Asp Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr 
            260                 265                 270         


Tyr Val Gly Tyr Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu 
        275                 280                 285             


Asn Gly Thr Ile Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser 
    290                 295                 300                 


Glu Thr Lys Cys Thr Leu Gly Ser Gly Gly Gly Gly Glu Ser Gln Val 
305                 310                 315                 320 


Arg Gln Gln Phe Ser Lys Asp Ile Glu Lys Leu Leu Asn Glu Gln Val 
                325                 330                 335     


Asn Lys Glu Met Gln Ser Ser Asn Leu Tyr Met Ser Met Ser Ser Trp 
            340                 345                 350         


Cys Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp His 
        355                 360                 365             


Ala Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe Leu Asn 
    370                 375                 380                 


Glu Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro Glu His 
385                 390                 395                 400 


Lys Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu His Glu 
                405                 410                 415     


Gln His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala Ile Lys 
            420                 425                 430         


Ser Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala Glu 
        435                 440                 445             


Gln His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys Ile Glu 
    450                 455                 460                 


Leu Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr Val 
465                 470                 475                 480 


Lys Gly Ile Ala Lys Ser Arg Lys Ser Gly Ser 
                485                 490     


<210> 101
<211> 491
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 101
His His His His His His His His Gly Pro Leu Glu Val Leu Phe Gln 
1               5                   10                  15      


Gly Pro Ser Ser Gln Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro 
            20                  25                  30          


Pro Ala Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys 
        35                  40                  45              


Val Phe Arg Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro 
    50                  55                  60                  


Phe Phe Ser Asn Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr 
65                  70                  75                  80  


Asn Gly Thr Lys Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly 
                85                  90                  95      


Val Tyr Phe Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Phe 
            100                 105                 110         


Phe Gly Thr Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn 
        115                 120                 125             


Asn Ala Thr Asn Val Val Ile Lys Val Cys Glu Asn Gln Thr Cys Asn 
    130                 135                 140                 


Asp Pro Phe Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met 
145                 150                 155                 160 


Glu Ser Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu 
                165                 170                 175     


Tyr Val Ser Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn 
            180                 185                 190         


Phe Lys Asn Leu Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe 
        195                 200                 205             


Lys Ile Tyr Ser Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro 
    210                 215                 220                 


Gln Gly Phe Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile 
225                 230                 235                 240 


Asn Ile Thr Arg Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu 
                245                 250                 255     


Thr Pro Gly Asp Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr 
            260                 265                 270         


Tyr Val Gly Tyr Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu 
        275                 280                 285             


Asn Gly Thr Ile Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser 
    290                 295                 300                 


Glu Thr Lys Cys Thr Leu Gly Ser Gly Gly Gly Gly Glu Ser Gln Val 
305                 310                 315                 320 


Arg Gln Gln Phe Ser Lys Asp Ile Glu Lys Leu Leu Asn Glu Gln Val 
                325                 330                 335     


Asn Lys Glu Met Gln Ser Ser Asn Leu Tyr Met Ser Met Ser Ser Trp 
            340                 345                 350         


Cys Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp His 
        355                 360                 365             


Ala Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe Leu Asn 
    370                 375                 380                 


Glu Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro Glu His 
385                 390                 395                 400 


Lys Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu His Glu 
                405                 410                 415     


Gln His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala Ile Lys 
            420                 425                 430         


Ser Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala Glu 
        435                 440                 445             


Gln His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys Ile Glu 
    450                 455                 460                 


Leu Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr Val 
465                 470                 475                 480 


Lys Gly Ile Ala Lys Ser Arg Lys Ser Gly Ser 
                485                 490     


<210> 102
<211> 491
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 102
His His His His His His His His Gly Pro Leu Glu Val Leu Phe Gln 
1               5                   10                  15      


Gly Pro Ser Ser Gln Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro 
            20                  25                  30          


Pro Ala Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys 
        35                  40                  45              


Val Phe Arg Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro 
    50                  55                  60                  


Phe Phe Ser Asn Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr 
65                  70                  75                  80  


Asn Gly Thr Lys Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly 
                85                  90                  95      


Val Tyr Phe Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile 
            100                 105                 110         


Phe Gly Thr Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn 
        115                 120                 125             


Asn Ala Thr Asn Asn Val Thr Lys Val Cys Glu Phe Gln Phe Cys Asn 
    130                 135                 140                 


Asp Pro Phe Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met 
145                 150                 155                 160 


Glu Ser Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu 
                165                 170                 175     


Tyr Val Ser Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn 
            180                 185                 190         


Phe Lys Asn Leu Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe 
        195                 200                 205             


Lys Ile Tyr Ser Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro 
    210                 215                 220                 


Gln Gly Phe Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile 
225                 230                 235                 240 


Asn Ile Thr Arg Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu 
                245                 250                 255     


Thr Pro Gly Asp Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr 
            260                 265                 270         


Tyr Val Gly Tyr Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu 
        275                 280                 285             


Asn Gly Thr Ile Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser 
    290                 295                 300                 


Glu Thr Lys Cys Thr Leu Gly Ser Gly Gly Gly Gly Glu Ser Gln Val 
305                 310                 315                 320 


Arg Gln Gln Phe Ser Lys Asp Ile Glu Lys Leu Leu Asn Glu Gln Val 
                325                 330                 335     


Asn Lys Glu Met Gln Ser Ser Asn Leu Tyr Met Ser Met Ser Ser Trp 
            340                 345                 350         


Cys Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp His 
        355                 360                 365             


Ala Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe Leu Asn 
    370                 375                 380                 


Glu Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro Glu His 
385                 390                 395                 400 


Lys Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu His Glu 
                405                 410                 415     


Gln His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala Ile Lys 
            420                 425                 430         


Ser Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala Glu 
        435                 440                 445             


Gln His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys Ile Glu 
    450                 455                 460                 


Leu Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr Val 
465                 470                 475                 480 


Lys Gly Ile Ala Lys Ser Arg Lys Ser Gly Ser 
                485                 490     


<210> 103
<211> 491
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 103
His His His His His His His His Gly Pro Leu Glu Val Leu Phe Gln 
1               5                   10                  15      


Gly Pro Ser Ser Gln Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro 
            20                  25                  30          


Pro Ala Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys 
        35                  40                  45              


Val Phe Arg Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro 
    50                  55                  60                  


Phe Phe Ser Asn Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr 
65                  70                  75                  80  


Asn Gly Thr Lys Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly 
                85                  90                  95      


Val Tyr Phe Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile 
            100                 105                 110         


Phe Gly Thr Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn 
        115                 120                 125             


Asn Ala Thr Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn 
    130                 135                 140                 


Asp Pro Phe Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met 
145                 150                 155                 160 


Glu Ser Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu 
                165                 170                 175     


Tyr Val Ser Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn 
            180                 185                 190         


Phe Lys Asn Leu Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe 
        195                 200                 205             


Lys Ile Tyr Ser Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro 
    210                 215                 220                 


Gln Gly Phe Ser Ala Leu Glu Pro Asn Val Thr Leu Pro Ile Gly Ile 
225                 230                 235                 240 


Asn Ile Thr Arg Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu 
                245                 250                 255     


Thr Pro Gly Asp Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr 
            260                 265                 270         


Tyr Val Gly Tyr Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu 
        275                 280                 285             


Asn Gly Thr Ile Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser 
    290                 295                 300                 


Glu Thr Lys Cys Thr Leu Gly Ser Gly Gly Gly Gly Glu Ser Gln Val 
305                 310                 315                 320 


Arg Gln Gln Phe Ser Lys Asp Ile Glu Lys Leu Leu Asn Glu Gln Val 
                325                 330                 335     


Asn Lys Glu Met Gln Ser Ser Asn Leu Tyr Met Ser Met Ser Ser Trp 
            340                 345                 350         


Cys Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp His 
        355                 360                 365             


Ala Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe Leu Asn 
    370                 375                 380                 


Glu Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro Glu His 
385                 390                 395                 400 


Lys Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu His Glu 
                405                 410                 415     


Gln His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala Ile Lys 
            420                 425                 430         


Ser Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala Glu 
        435                 440                 445             


Gln His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys Ile Glu 
    450                 455                 460                 


Leu Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr Val 
465                 470                 475                 480 


Lys Gly Ile Ala Lys Ser Arg Lys Ser Gly Ser 
                485                 490     


<210> 104
<211> 491
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 104
His His His His His His His His Gly Pro Leu Glu Val Leu Phe Gln 
1               5                   10                  15      


Gly Pro Ser Ser Gln Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro 
            20                  25                  30          


Pro Ala Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys 
        35                  40                  45              


Val Phe Arg Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro 
    50                  55                  60                  


Phe Phe Ser Asn Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr 
65                  70                  75                  80  


Asn Gly Thr Lys Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly 
                85                  90                  95      


Val Tyr Phe Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile 
            100                 105                 110         


Phe Gly Thr Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn 
        115                 120                 125             


Asn Ala Thr Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn 
    130                 135                 140                 


Asp Pro Phe Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met 
145                 150                 155                 160 


Glu Ser Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu 
                165                 170                 175     


Tyr Val Ser Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn 
            180                 185                 190         


Phe Lys Asn Leu Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe 
        195                 200                 205             


Lys Ile Tyr Ser Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro 
    210                 215                 220                 


Gln Gly Phe Ser Ala Leu Glu Pro Leu Asn Asp Thr Pro Ile Gly Ile 
225                 230                 235                 240 


Asn Ile Thr Arg Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu 
                245                 250                 255     


Thr Pro Gly Asp Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr 
            260                 265                 270         


Tyr Val Gly Tyr Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu 
        275                 280                 285             


Asn Gly Thr Ile Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser 
    290                 295                 300                 


Glu Thr Lys Cys Thr Leu Gly Ser Gly Gly Gly Gly Glu Ser Gln Val 
305                 310                 315                 320 


Arg Gln Gln Phe Ser Lys Asp Ile Glu Lys Leu Leu Asn Glu Gln Val 
                325                 330                 335     


Asn Lys Glu Met Gln Ser Ser Asn Leu Tyr Met Ser Met Ser Ser Trp 
            340                 345                 350         


Cys Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp His 
        355                 360                 365             


Ala Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe Leu Asn 
    370                 375                 380                 


Glu Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro Glu His 
385                 390                 395                 400 


Lys Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu His Glu 
                405                 410                 415     


Gln His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala Ile Lys 
            420                 425                 430         


Ser Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala Glu 
        435                 440                 445             


Gln His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys Ile Glu 
    450                 455                 460                 


Leu Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr Val 
465                 470                 475                 480 


Lys Gly Ile Ala Lys Ser Arg Lys Ser Gly Ser 
                485                 490     


<210> 105
<211> 825
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 105
Ser Ser Gln Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala 
1               5                   10                  15      


Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe 
            20                  25                  30          


Arg Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe 
        35                  40                  45              


Ser Asn Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly 
    50                  55                  60                  


Thr Lys Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr 
65                  70                  75                  80  


Phe Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly 
                85                  90                  95      


Thr Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala 
            100                 105                 110         


Thr Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro 
        115                 120                 125             


Phe Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser 
    130                 135                 140                 


Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val 
145                 150                 155                 160 


Ser Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys 
                165                 170                 175     


Asn Leu Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile 
            180                 185                 190         


Tyr Ser Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly 
        195                 200                 205             


Phe Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile 
    210                 215                 220                 


Thr Arg Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro 
225                 230                 235                 240 


Gly Asp Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val 
                245                 250                 255     


Gly Tyr Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly 
            260                 265                 270         


Thr Ile Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr 
        275                 280                 285             


Lys Cys Thr Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr 
    290                 295                 300                 


Ser Asn Phe Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn 
305                 310                 315                 320 


Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe 
                325                 330                 335     


Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala 
            340                 345                 350         


Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys 
        355                 360                 365             


Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val 
    370                 375                 380                 


Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala 
385                 390                 395                 400 


Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp 
                405                 410                 415     


Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser 
            420                 425                 430         


Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser 
        435                 440                 445             


Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala 
    450                 455                 460                 


Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro 
465                 470                 475                 480 


Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro 
                485                 490                 495     


Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr 
            500                 505                 510         


Val Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val 
        515                 520                 525             


Asn Phe Asn Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser 
    530                 535                 540                 


Asn Lys Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp 
545                 550                 555                 560 


Thr Thr Asp Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile 
                565                 570                 575     


Thr Pro Cys Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn 
            580                 585                 590         


Thr Ser Asn Gln Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu 
        595                 600                 605             


Val Pro Val Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val 
    610                 615                 620                 


Tyr Ser Thr Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile 
625                 630                 635                 640 


Gly Ala Glu His Gly Ser Gly Gly Gly Gly Glu Ser Gln Val Arg Gln 
                645                 650                 655     


Gln Phe Ser Lys Asp Ile Glu Lys Leu Leu Asn Glu Gln Val Asn Lys 
            660                 665                 670         


Glu Met Gln Ser Ser Asn Leu Tyr Met Ser Met Ser Ser Trp Cys Tyr 
        675                 680                 685             


Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp His Ala Ala 
    690                 695                 700                 


Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe Leu Asn Glu Asn 
705                 710                 715                 720 


Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro Glu His Lys Phe 
                725                 730                 735     


Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu His Glu Gln His 
            740                 745                 750         


Ile Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala Ile Lys Ser Lys 
        755                 760                 765             


Asp His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala Glu Gln His 
    770                 775                 780                 


Glu Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys Ile Glu Leu Ile 
785                 790                 795                 800 


Gly Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr Val Lys Gly 
                805                 810                 815     


Ile Ala Lys Ser Arg Lys Ser Gly Ser 
            820                 825 


<210> 106
<211> 825
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 106
Ser Ser Gln Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala 
1               5                   10                  15      


Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe 
            20                  25                  30          


Arg Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe 
        35                  40                  45              


Ser Asn Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly 
    50                  55                  60                  


Thr Lys Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr 
65                  70                  75                  80  


Phe Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly 
                85                  90                  95      


Thr Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala 
            100                 105                 110         


Thr Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro 
        115                 120                 125             


Phe Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser 
    130                 135                 140                 


Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val 
145                 150                 155                 160 


Ser Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys 
                165                 170                 175     


Asn Leu Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile 
            180                 185                 190         


Tyr Ser Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly 
        195                 200                 205             


Phe Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile 
    210                 215                 220                 


Thr Arg Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro 
225                 230                 235                 240 


Gly Asp Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val 
                245                 250                 255     


Gly Tyr Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly 
            260                 265                 270         


Thr Ile Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr 
        275                 280                 285             


Lys Cys Thr Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr 
    290                 295                 300                 


Ser Asn Phe Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn 
305                 310                 315                 320 


Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe 
                325                 330                 335     


Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala 
            340                 345                 350         


Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys 
        355                 360                 365             


Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val 
    370                 375                 380                 


Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala 
385                 390                 395                 400 


Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp 
                405                 410                 415     


Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser 
            420                 425                 430         


Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser 
        435                 440                 445             


Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala 
    450                 455                 460                 


Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro 
465                 470                 475                 480 


Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro 
                485                 490                 495     


Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr 
            500                 505                 510         


Val Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val 
        515                 520                 525             


Asn Phe Asn Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser 
    530                 535                 540                 


Asn Lys Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp 
545                 550                 555                 560 


Thr Thr Asp Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile 
                565                 570                 575     


Thr Pro Cys Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn 
            580                 585                 590         


Thr Ser Asn Gln Val Ala Val Asn Tyr Thr Asp Val Asn Cys Thr Glu 
        595                 600                 605             


Val Pro Val Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val 
    610                 615                 620                 


Tyr Ser Thr Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile 
625                 630                 635                 640 


Gly Ala Glu His Gly Ser Gly Gly Gly Gly Glu Ser Gln Val Arg Gln 
                645                 650                 655     


Gln Phe Ser Lys Asp Ile Glu Lys Leu Leu Asn Glu Gln Val Asn Lys 
            660                 665                 670         


Glu Met Gln Ser Ser Asn Leu Tyr Met Ser Met Ser Ser Trp Cys Tyr 
        675                 680                 685             


Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp His Ala Ala 
    690                 695                 700                 


Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe Leu Asn Glu Asn 
705                 710                 715                 720 


Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro Glu His Lys Phe 
                725                 730                 735     


Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu His Glu Gln His 
            740                 745                 750         


Ile Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala Ile Lys Ser Lys 
        755                 760                 765             


Asp His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala Glu Gln His 
    770                 775                 780                 


Glu Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys Ile Glu Leu Ile 
785                 790                 795                 800 


Gly Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr Val Lys Gly 
                805                 810                 815     


Ile Ala Lys Ser Arg Lys Ser Gly Ser 
            820                 825 


<210> 107
<211> 866
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 107
Ser Ser Gln Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala 
1               5                   10                  15      


Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe 
            20                  25                  30          


Arg Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe 
        35                  40                  45              


Ser Asn Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly 
    50                  55                  60                  


Thr Lys Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr 
65                  70                  75                  80  


Phe Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly 
                85                  90                  95      


Thr Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala 
            100                 105                 110         


Thr Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro 
        115                 120                 125             


Phe Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser 
    130                 135                 140                 


Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val 
145                 150                 155                 160 


Ser Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys 
                165                 170                 175     


Asn Leu Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile 
            180                 185                 190         


Tyr Ser Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly 
        195                 200                 205             


Phe Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile 
    210                 215                 220                 


Thr Arg Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro 
225                 230                 235                 240 


Gly Asp Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val 
                245                 250                 255     


Gly Tyr Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly 
            260                 265                 270         


Thr Ile Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr 
        275                 280                 285             


Lys Cys Thr Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr 
    290                 295                 300                 


Ser Asn Phe Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn 
305                 310                 315                 320 


Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe 
                325                 330                 335     


Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala 
            340                 345                 350         


Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys 
        355                 360                 365             


Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val 
    370                 375                 380                 


Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala 
385                 390                 395                 400 


Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp 
                405                 410                 415     


Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser 
            420                 425                 430         


Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser 
        435                 440                 445             


Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala 
    450                 455                 460                 


Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro 
465                 470                 475                 480 


Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro 
                485                 490                 495     


Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr 
            500                 505                 510         


Val Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val 
        515                 520                 525             


Asn Phe Asn Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser 
    530                 535                 540                 


Asn Lys Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp 
545                 550                 555                 560 


Thr Thr Asp Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile 
                565                 570                 575     


Thr Pro Cys Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn 
            580                 585                 590         


Thr Ser Asn Gln Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu 
        595                 600                 605             


Val Pro Val Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val 
    610                 615                 620                 


Tyr Ser Thr Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile 
625                 630                 635                 640 


Gly Ala Glu His Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly 
                645                 650                 655     


Ala Gly Ile Cys Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro Gly Ser 
            660                 665                 670         


Ala Ser Ser Val Ala Ser Gln Ser Ile Ile Ala Tyr Thr Gly Ser Gly 
        675                 680                 685             


Gly Gly Gly Glu Ser Gln Val Arg Gln Gln Phe Ser Lys Asp Ile Glu 
    690                 695                 700                 


Lys Leu Leu Asn Glu Gln Val Asn Lys Glu Met Gln Ser Ser Asn Leu 
705                 710                 715                 720 


Tyr Met Ser Met Ser Ser Trp Cys Tyr Thr His Ser Leu Asp Gly Ala 
                725                 730                 735     


Gly Leu Phe Leu Phe Asp His Ala Ala Glu Glu Tyr Glu His Ala Lys 
            740                 745                 750         


Lys Leu Ile Ile Phe Leu Asn Glu Asn Asn Val Pro Val Gln Leu Thr 
        755                 760                 765             


Ser Ile Ser Ala Pro Glu His Lys Phe Glu Gly Leu Thr Gln Ile Phe 
    770                 775                 780                 


Gln Lys Ala Tyr Glu His Glu Gln His Ile Ser Glu Ser Ile Asn Asn 
785                 790                 795                 800 


Ile Val Asp His Ala Ile Lys Ser Lys Asp His Ala Thr Phe Asn Phe 
                805                 810                 815     


Leu Gln Trp Tyr Val Ala Glu Gln His Glu Glu Glu Val Leu Phe Lys 
            820                 825                 830         


Asp Ile Leu Asp Lys Ile Glu Leu Ile Gly Asn Glu Asn His Gly Leu 
        835                 840                 845             


Tyr Leu Ala Asp Gln Tyr Val Lys Gly Ile Ala Lys Ser Arg Lys Ser 
    850                 855                 860                 


Gly Ser 
865     


<210> 108
<211> 855
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 108
Ser Ser Gln Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala 
1               5                   10                  15      


Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe 
            20                  25                  30          


Arg Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe 
        35                  40                  45              


Ser Asn Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly 
    50                  55                  60                  


Thr Lys Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr 
65                  70                  75                  80  


Phe Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly 
                85                  90                  95      


Thr Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala 
            100                 105                 110         


Thr Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro 
        115                 120                 125             


Phe Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser 
    130                 135                 140                 


Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val 
145                 150                 155                 160 


Ser Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys 
                165                 170                 175     


Asn Leu Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile 
            180                 185                 190         


Tyr Ser Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly 
        195                 200                 205             


Phe Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile 
    210                 215                 220                 


Thr Arg Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro 
225                 230                 235                 240 


Gly Asp Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val 
                245                 250                 255     


Gly Tyr Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly 
            260                 265                 270         


Thr Ile Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr 
        275                 280                 285             


Lys Cys Thr Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr 
    290                 295                 300                 


Ser Asn Phe Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn 
305                 310                 315                 320 


Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe 
                325                 330                 335     


Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala 
            340                 345                 350         


Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys 
        355                 360                 365             


Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val 
    370                 375                 380                 


Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala 
385                 390                 395                 400 


Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp 
                405                 410                 415     


Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser 
            420                 425                 430         


Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser 
        435                 440                 445             


Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala 
    450                 455                 460                 


Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro 
465                 470                 475                 480 


Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro 
                485                 490                 495     


Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr 
            500                 505                 510         


Val Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val 
        515                 520                 525             


Asn Phe Asn Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser 
    530                 535                 540                 


Asn Lys Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp 
545                 550                 555                 560 


Thr Thr Asp Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile 
                565                 570                 575     


Thr Pro Cys Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn 
            580                 585                 590         


Thr Ser Asn Gln Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu 
        595                 600                 605             


Val Pro Val Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val 
    610                 615                 620                 


Tyr Ser Thr Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile 
625                 630                 635                 640 


Gly Ala Glu His Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly 
                645                 650                 655     


Ala Gly Ile Cys Ala Ser Tyr Gln Thr Gly Ser Gln Ser Ile Ile Ala 
            660                 665                 670         


Tyr Thr Gly Ser Gly Gly Gly Gly Glu Ser Gln Val Arg Gln Gln Phe 
        675                 680                 685             


Ser Lys Asp Ile Glu Lys Leu Leu Asn Glu Gln Val Asn Lys Glu Met 
    690                 695                 700                 


Gln Ser Ser Asn Leu Tyr Met Ser Met Ser Ser Trp Cys Tyr Thr His 
705                 710                 715                 720 


Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp His Ala Ala Glu Glu 
                725                 730                 735     


Tyr Glu His Ala Lys Lys Leu Ile Ile Phe Leu Asn Glu Asn Asn Val 
            740                 745                 750         


Pro Val Gln Leu Thr Ser Ile Ser Ala Pro Glu His Lys Phe Glu Gly 
        755                 760                 765             


Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu His Glu Gln His Ile Ser 
    770                 775                 780                 


Glu Ser Ile Asn Asn Ile Val Asp His Ala Ile Lys Ser Lys Asp His 
785                 790                 795                 800 


Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala Glu Gln His Glu Glu 
                805                 810                 815     


Glu Val Leu Phe Lys Asp Ile Leu Asp Lys Ile Glu Leu Ile Gly Asn 
            820                 825                 830         


Glu Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr Val Lys Gly Ile Ala 
        835                 840                 845             


Lys Ser Arg Lys Ser Gly Ser 
    850                 855 


<210> 109
<211> 856
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 109
Ser Ser Gln Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala 
1               5                   10                  15      


Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe 
            20                  25                  30          


Arg Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe 
        35                  40                  45              


Ser Asn Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly 
    50                  55                  60                  


Thr Lys Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr 
65                  70                  75                  80  


Phe Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly 
                85                  90                  95      


Thr Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala 
            100                 105                 110         


Thr Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro 
        115                 120                 125             


Phe Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser 
    130                 135                 140                 


Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val 
145                 150                 155                 160 


Ser Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys 
                165                 170                 175     


Asn Leu Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile 
            180                 185                 190         


Tyr Ser Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly 
        195                 200                 205             


Phe Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile 
    210                 215                 220                 


Thr Arg Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro 
225                 230                 235                 240 


Gly Asp Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val 
                245                 250                 255     


Gly Tyr Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly 
            260                 265                 270         


Thr Ile Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr 
        275                 280                 285             


Lys Cys Thr Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr 
    290                 295                 300                 


Ser Asn Phe Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn 
305                 310                 315                 320 


Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe 
                325                 330                 335     


Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala 
            340                 345                 350         


Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys 
        355                 360                 365             


Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val 
    370                 375                 380                 


Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala 
385                 390                 395                 400 


Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp 
                405                 410                 415     


Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser 
            420                 425                 430         


Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser 
        435                 440                 445             


Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala 
    450                 455                 460                 


Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro 
465                 470                 475                 480 


Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro 
                485                 490                 495     


Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr 
            500                 505                 510         


Val Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val 
        515                 520                 525             


Asn Phe Asn Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser 
    530                 535                 540                 


Asn Lys Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp 
545                 550                 555                 560 


Thr Thr Asp Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile 
                565                 570                 575     


Thr Pro Cys Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn 
            580                 585                 590         


Thr Ser Asn Gln Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu 
        595                 600                 605             


Val Pro Val Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val 
    610                 615                 620                 


Tyr Ser Thr Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile 
625                 630                 635                 640 


Gly Ala Glu His Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly 
                645                 650                 655     


Ala Gly Ile Cys Ala Ser Tyr Gln Thr Gly Gly Ser Gln Ser Ile Ile 
            660                 665                 670         


Ala Tyr Thr Gly Ser Gly Gly Gly Gly Glu Ser Gln Val Arg Gln Gln 
        675                 680                 685             


Phe Ser Lys Asp Ile Glu Lys Leu Leu Asn Glu Gln Val Asn Lys Glu 
    690                 695                 700                 


Met Gln Ser Ser Asn Leu Tyr Met Ser Met Ser Ser Trp Cys Tyr Thr 
705                 710                 715                 720 


His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp His Ala Ala Glu 
                725                 730                 735     


Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe Leu Asn Glu Asn Asn 
            740                 745                 750         


Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro Glu His Lys Phe Glu 
        755                 760                 765             


Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu His Glu Gln His Ile 
    770                 775                 780                 


Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala Ile Lys Ser Lys Asp 
785                 790                 795                 800 


His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala Glu Gln His Glu 
                805                 810                 815     


Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys Ile Glu Leu Ile Gly 
            820                 825                 830         


Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr Val Lys Gly Ile 
        835                 840                 845             


Ala Lys Ser Arg Lys Ser Gly Ser 
    850                 855     


<210> 110
<211> 856
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 110
Ser Ser Gln Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala 
1               5                   10                  15      


Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe 
            20                  25                  30          


Arg Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe 
        35                  40                  45              


Ser Asn Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly 
    50                  55                  60                  


Thr Lys Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr 
65                  70                  75                  80  


Phe Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly 
                85                  90                  95      


Thr Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala 
            100                 105                 110         


Thr Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro 
        115                 120                 125             


Phe Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser 
    130                 135                 140                 


Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val 
145                 150                 155                 160 


Ser Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys 
                165                 170                 175     


Asn Leu Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile 
            180                 185                 190         


Tyr Ser Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly 
        195                 200                 205             


Phe Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile 
    210                 215                 220                 


Thr Arg Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro 
225                 230                 235                 240 


Gly Asp Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val 
                245                 250                 255     


Gly Tyr Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly 
            260                 265                 270         


Thr Ile Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr 
        275                 280                 285             


Lys Cys Thr Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr 
    290                 295                 300                 


Ser Asn Phe Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn 
305                 310                 315                 320 


Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe 
                325                 330                 335     


Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala 
            340                 345                 350         


Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys 
        355                 360                 365             


Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val 
    370                 375                 380                 


Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala 
385                 390                 395                 400 


Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp 
                405                 410                 415     


Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser 
            420                 425                 430         


Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser 
        435                 440                 445             


Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala 
    450                 455                 460                 


Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro 
465                 470                 475                 480 


Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro 
                485                 490                 495     


Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr 
            500                 505                 510         


Val Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val 
        515                 520                 525             


Asn Phe Asn Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser 
    530                 535                 540                 


Asn Lys Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp 
545                 550                 555                 560 


Thr Thr Asp Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile 
                565                 570                 575     


Thr Pro Cys Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn 
            580                 585                 590         


Thr Ser Asn Gln Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu 
        595                 600                 605             


Val Pro Val Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val 
    610                 615                 620                 


Tyr Ser Thr Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile 
625                 630                 635                 640 


Gly Ala Glu His Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly 
                645                 650                 655     


Ala Gly Ile Cys Ala Ser Tyr Gln Thr Pro Gly Ser Gln Ser Ile Ile 
            660                 665                 670         


Ala Tyr Thr Gly Ser Gly Gly Gly Gly Glu Ser Gln Val Arg Gln Gln 
        675                 680                 685             


Phe Ser Lys Asp Ile Glu Lys Leu Leu Asn Glu Gln Val Asn Lys Glu 
    690                 695                 700                 


Met Gln Ser Ser Asn Leu Tyr Met Ser Met Ser Ser Trp Cys Tyr Thr 
705                 710                 715                 720 


His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp His Ala Ala Glu 
                725                 730                 735     


Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe Leu Asn Glu Asn Asn 
            740                 745                 750         


Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro Glu His Lys Phe Glu 
        755                 760                 765             


Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu His Glu Gln His Ile 
    770                 775                 780                 


Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala Ile Lys Ser Lys Asp 
785                 790                 795                 800 


His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala Glu Gln His Glu 
                805                 810                 815     


Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys Ile Glu Leu Ile Gly 
            820                 825                 830         


Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr Val Lys Gly Ile 
        835                 840                 845             


Ala Lys Ser Arg Lys Ser Gly Ser 
    850                 855     


<210> 111
<211> 848
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 111
Ser Ser Gln Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala 
1               5                   10                  15      


Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe 
            20                  25                  30          


Arg Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe 
        35                  40                  45              


Ser Asn Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly 
    50                  55                  60                  


Thr Lys Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr 
65                  70                  75                  80  


Phe Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly 
                85                  90                  95      


Thr Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala 
            100                 105                 110         


Thr Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro 
        115                 120                 125             


Phe Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser 
    130                 135                 140                 


Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val 
145                 150                 155                 160 


Ser Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys 
                165                 170                 175     


Asn Leu Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile 
            180                 185                 190         


Tyr Ser Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly 
        195                 200                 205             


Phe Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile 
    210                 215                 220                 


Thr Arg Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro 
225                 230                 235                 240 


Gly Asp Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val 
                245                 250                 255     


Gly Tyr Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly 
            260                 265                 270         


Thr Ile Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr 
        275                 280                 285             


Lys Cys Thr Leu Lys Ser Phe Thr Val Glu Lys Gly Asn Tyr Thr Thr 
    290                 295                 300                 


Ser Asn Phe Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn 
305                 310                 315                 320 


Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe 
                325                 330                 335     


Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala 
            340                 345                 350         


Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys 
        355                 360                 365             


Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val 
    370                 375                 380                 


Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala 
385                 390                 395                 400 


Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp 
                405                 410                 415     


Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser 
            420                 425                 430         


Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser 
        435                 440                 445             


Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala 
    450                 455                 460                 


Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro 
465                 470                 475                 480 


Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro 
                485                 490                 495     


Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr 
            500                 505                 510         


Val Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val 
        515                 520                 525             


Asn Phe Asn Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser 
    530                 535                 540                 


Asn Lys Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp 
545                 550                 555                 560 


Thr Thr Asp Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile 
                565                 570                 575     


Thr Pro Cys Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn 
            580                 585                 590         


Thr Ser Asn Gln Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu 
        595                 600                 605             


Val Pro Val Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val 
    610                 615                 620                 


Tyr Ser Thr Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile 
625                 630                 635                 640 


Gly Ala Glu His Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly 
                645                 650                 655     


Ala Gly Ile Cys Ala Ser Tyr Gln Thr Gln Thr Gly Ser Gly Gly Gly 
            660                 665                 670         


Gly Glu Ser Gln Val Arg Gln Gln Phe Ser Lys Asp Ile Glu Lys Leu 
        675                 680                 685             


Leu Asn Glu Gln Val Asn Lys Glu Met Gln Ser Ser Asn Leu Tyr Met 
    690                 695                 700                 


Ser Met Ser Ser Trp Cys Tyr Thr His Ser Leu Asp Gly Ala Gly Leu 
705                 710                 715                 720 


Phe Leu Phe Asp His Ala Ala Glu Glu Tyr Glu His Ala Lys Lys Leu 
                725                 730                 735     


Ile Ile Phe Leu Asn Glu Asn Asn Val Pro Val Gln Leu Thr Ser Ile 
            740                 745                 750         


Ser Ala Pro Glu His Lys Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys 
        755                 760                 765             


Ala Tyr Glu His Glu Gln His Ile Ser Glu Ser Ile Asn Asn Ile Val 
    770                 775                 780                 


Asp His Ala Ile Lys Ser Lys Asp His Ala Thr Phe Asn Phe Leu Gln 
785                 790                 795                 800 


Trp Tyr Val Ala Glu Gln His Glu Glu Glu Val Leu Phe Lys Asp Ile 
                805                 810                 815     


Leu Asp Lys Ile Glu Leu Ile Gly Asn Glu Asn His Gly Leu Tyr Leu 
            820                 825                 830         


Ala Asp Gln Tyr Val Lys Gly Ile Ala Lys Ser Arg Lys Ser Gly Ser 
        835                 840                 845             


<210> 112
<211> 848
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 112
Ser Ser Gln Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala 
1               5                   10                  15      


Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe 
            20                  25                  30          


Arg Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe 
        35                  40                  45              


Ser Asn Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly 
    50                  55                  60                  


Thr Lys Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr 
65                  70                  75                  80  


Phe Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly 
                85                  90                  95      


Thr Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala 
            100                 105                 110         


Thr Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro 
        115                 120                 125             


Phe Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser 
    130                 135                 140                 


Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val 
145                 150                 155                 160 


Ser Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys 
                165                 170                 175     


Asn Leu Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile 
            180                 185                 190         


Tyr Ser Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly 
        195                 200                 205             


Phe Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile 
    210                 215                 220                 


Thr Arg Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro 
225                 230                 235                 240 


Gly Asp Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val 
                245                 250                 255     


Gly Tyr Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly 
            260                 265                 270         


Thr Ile Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr 
        275                 280                 285             


Lys Cys Thr Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr 
    290                 295                 300                 


Ser Asn Phe Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn 
305                 310                 315                 320 


Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe 
                325                 330                 335     


Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala 
            340                 345                 350         


Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys 
        355                 360                 365             


Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val 
    370                 375                 380                 


Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala 
385                 390                 395                 400 


Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp 
                405                 410                 415     


Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser 
            420                 425                 430         


Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser 
        435                 440                 445             


Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala 
    450                 455                 460                 


Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro 
465                 470                 475                 480 


Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro 
                485                 490                 495     


Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr 
            500                 505                 510         


Val Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val 
        515                 520                 525             


Asn Phe Asn Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser 
    530                 535                 540                 


Asn Lys Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp 
545                 550                 555                 560 


Thr Thr Asp Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile 
                565                 570                 575     


Thr Pro Cys Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn 
            580                 585                 590         


Thr Ser Asn Gln Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu 
        595                 600                 605             


Val Pro Val Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val 
    610                 615                 620                 


Tyr Ser Thr Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Asn 
625                 630                 635                 640 


Gly Ser Glu His Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly 
                645                 650                 655     


Ala Gly Ile Cys Ala Ser Tyr Gln Thr Gln Thr Gly Ser Gly Gly Gly 
            660                 665                 670         


Gly Glu Ser Gln Val Arg Gln Gln Phe Ser Lys Asp Ile Glu Lys Leu 
        675                 680                 685             


Leu Asn Glu Gln Val Asn Lys Glu Met Gln Ser Ser Asn Leu Tyr Met 
    690                 695                 700                 


Ser Met Ser Ser Trp Cys Tyr Thr His Ser Leu Asp Gly Ala Gly Leu 
705                 710                 715                 720 


Phe Leu Phe Asp His Ala Ala Glu Glu Tyr Glu His Ala Lys Lys Leu 
                725                 730                 735     


Ile Ile Phe Leu Asn Glu Asn Asn Val Pro Val Gln Leu Thr Ser Ile 
            740                 745                 750         


Ser Ala Pro Glu His Lys Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys 
        755                 760                 765             


Ala Tyr Glu His Glu Gln His Ile Ser Glu Ser Ile Asn Asn Ile Val 
    770                 775                 780                 


Asp His Ala Ile Lys Ser Lys Asp His Ala Thr Phe Asn Phe Leu Gln 
785                 790                 795                 800 


Trp Tyr Val Ala Glu Gln His Glu Glu Glu Val Leu Phe Lys Asp Ile 
                805                 810                 815     


Leu Asp Lys Ile Glu Leu Ile Gly Asn Glu Asn His Gly Leu Tyr Leu 
            820                 825                 830         


Ala Asp Gln Tyr Val Lys Gly Ile Ala Lys Ser Arg Lys Ser Gly Ser 
        835                 840                 845             


<210> 113
<211> 848
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 113
Ser Ser Gln Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala 
1               5                   10                  15      


Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe 
            20                  25                  30          


Arg Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe 
        35                  40                  45              


Ser Asn Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly 
    50                  55                  60                  


Thr Lys Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr 
65                  70                  75                  80  


Phe Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly 
                85                  90                  95      


Thr Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala 
            100                 105                 110         


Thr Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro 
        115                 120                 125             


Phe Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser 
    130                 135                 140                 


Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val 
145                 150                 155                 160 


Ser Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys 
                165                 170                 175     


Asn Leu Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile 
            180                 185                 190         


Tyr Ser Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly 
        195                 200                 205             


Phe Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile 
    210                 215                 220                 


Thr Arg Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro 
225                 230                 235                 240 


Gly Asp Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val 
                245                 250                 255     


Gly Tyr Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly 
            260                 265                 270         


Thr Ile Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr 
        275                 280                 285             


Lys Cys Thr Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr 
    290                 295                 300                 


Cys Asn Phe Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn 
305                 310                 315                 320 


Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe 
                325                 330                 335     


Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala 
            340                 345                 350         


Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys 
        355                 360                 365             


Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val 
    370                 375                 380                 


Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala 
385                 390                 395                 400 


Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp 
                405                 410                 415     


Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser 
            420                 425                 430         


Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser 
        435                 440                 445             


Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala 
    450                 455                 460                 


Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro 
465                 470                 475                 480 


Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro 
                485                 490                 495     


Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr 
            500                 505                 510         


Val Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val 
        515                 520                 525             


Asn Phe Asn Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser 
    530                 535                 540                 


Asn Lys Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp 
545                 550                 555                 560 


Thr Thr Asp Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile 
                565                 570                 575     


Thr Pro Cys Ser Phe Gly Gly Cys Ser Val Ile Thr Pro Gly Thr Asn 
            580                 585                 590         


Thr Ser Asn Gln Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu 
        595                 600                 605             


Val Pro Val Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val 
    610                 615                 620                 


Tyr Ser Thr Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile 
625                 630                 635                 640 


Gly Ala Glu His Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly 
                645                 650                 655     


Ala Gly Ile Cys Ala Ser Tyr Gln Thr Gln Thr Gly Ser Gly Gly Gly 
            660                 665                 670         


Gly Glu Ser Gln Val Arg Gln Gln Phe Ser Lys Asp Ile Glu Lys Leu 
        675                 680                 685             


Leu Asn Glu Gln Val Asn Lys Glu Met Gln Ser Ser Asn Leu Tyr Met 
    690                 695                 700                 


Ser Met Ser Ser Trp Cys Tyr Thr His Ser Leu Asp Gly Ala Gly Leu 
705                 710                 715                 720 


Phe Leu Phe Asp His Ala Ala Glu Glu Tyr Glu His Ala Lys Lys Leu 
                725                 730                 735     


Ile Ile Phe Leu Asn Glu Asn Asn Val Pro Val Gln Leu Thr Ser Ile 
            740                 745                 750         


Ser Ala Pro Glu His Lys Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys 
        755                 760                 765             


Ala Tyr Glu His Glu Gln His Ile Ser Glu Ser Ile Asn Asn Ile Val 
    770                 775                 780                 


Asp His Ala Ile Lys Ser Lys Asp His Ala Thr Phe Asn Phe Leu Gln 
785                 790                 795                 800 


Trp Tyr Val Ala Glu Gln His Glu Glu Glu Val Leu Phe Lys Asp Ile 
                805                 810                 815     


Leu Asp Lys Ile Glu Leu Ile Gly Asn Glu Asn His Gly Leu Tyr Leu 
            820                 825                 830         


Ala Asp Gln Tyr Val Lys Gly Ile Ala Lys Ser Arg Lys Ser Gly Ser 
        835                 840                 845             


<210> 114
<211> 848
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 114
Ser Ser Gln Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala 
1               5                   10                  15      


Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe 
            20                  25                  30          


Arg Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe 
        35                  40                  45              


Ser Asn Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly 
    50                  55                  60                  


Thr Lys Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr 
65                  70                  75                  80  


Phe Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly 
                85                  90                  95      


Thr Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala 
            100                 105                 110         


Thr Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro 
        115                 120                 125             


Phe Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser 
    130                 135                 140                 


Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val 
145                 150                 155                 160 


Ser Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys 
                165                 170                 175     


Asn Leu Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile 
            180                 185                 190         


Tyr Ser Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly 
        195                 200                 205             


Phe Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile 
    210                 215                 220                 


Thr Arg Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro 
225                 230                 235                 240 


Gly Asp Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val 
                245                 250                 255     


Gly Tyr Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly 
            260                 265                 270         


Thr Ile Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr 
        275                 280                 285             


Lys Cys Thr Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr 
    290                 295                 300                 


Ser Asn Phe Arg Cys Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn 
305                 310                 315                 320 


Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe 
                325                 330                 335     


Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala 
            340                 345                 350         


Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys 
        355                 360                 365             


Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val 
    370                 375                 380                 


Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala 
385                 390                 395                 400 


Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp 
                405                 410                 415     


Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser 
            420                 425                 430         


Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser 
        435                 440                 445             


Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala 
    450                 455                 460                 


Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro 
465                 470                 475                 480 


Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro 
                485                 490                 495     


Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr 
            500                 505                 510         


Val Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val 
        515                 520                 525             


Asn Phe Asn Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser 
    530                 535                 540                 


Asn Lys Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp 
545                 550                 555                 560 


Thr Thr Asp Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile 
                565                 570                 575     


Thr Pro Cys Cys Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn 
            580                 585                 590         


Thr Ser Asn Gln Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu 
        595                 600                 605             


Val Pro Val Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val 
    610                 615                 620                 


Tyr Ser Thr Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile 
625                 630                 635                 640 


Gly Ala Glu His Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly 
                645                 650                 655     


Ala Gly Ile Cys Ala Ser Tyr Gln Thr Gln Thr Gly Ser Gly Gly Gly 
            660                 665                 670         


Gly Glu Ser Gln Val Arg Gln Gln Phe Ser Lys Asp Ile Glu Lys Leu 
        675                 680                 685             


Leu Asn Glu Gln Val Asn Lys Glu Met Gln Ser Ser Asn Leu Tyr Met 
    690                 695                 700                 


Ser Met Ser Ser Trp Cys Tyr Thr His Ser Leu Asp Gly Ala Gly Leu 
705                 710                 715                 720 


Phe Leu Phe Asp His Ala Ala Glu Glu Tyr Glu His Ala Lys Lys Leu 
                725                 730                 735     


Ile Ile Phe Leu Asn Glu Asn Asn Val Pro Val Gln Leu Thr Ser Ile 
            740                 745                 750         


Ser Ala Pro Glu His Lys Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys 
        755                 760                 765             


Ala Tyr Glu His Glu Gln His Ile Ser Glu Ser Ile Asn Asn Ile Val 
    770                 775                 780                 


Asp His Ala Ile Lys Ser Lys Asp His Ala Thr Phe Asn Phe Leu Gln 
785                 790                 795                 800 


Trp Tyr Val Ala Glu Gln His Glu Glu Glu Val Leu Phe Lys Asp Ile 
                805                 810                 815     


Leu Asp Lys Ile Glu Leu Ile Gly Asn Glu Asn His Gly Leu Tyr Leu 
            820                 825                 830         


Ala Asp Gln Tyr Val Lys Gly Ile Ala Lys Ser Arg Lys Ser Gly Ser 
        835                 840                 845             


<210> 115
<211> 848
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 115
Ser Ser Gln Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala 
1               5                   10                  15      


Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe 
            20                  25                  30          


Arg Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe 
        35                  40                  45              


Ser Asn Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly 
    50                  55                  60                  


Thr Lys Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr 
65                  70                  75                  80  


Phe Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly 
                85                  90                  95      


Thr Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala 
            100                 105                 110         


Thr Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro 
        115                 120                 125             


Phe Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser 
    130                 135                 140                 


Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val 
145                 150                 155                 160 


Ser Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys 
                165                 170                 175     


Asn Leu Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile 
            180                 185                 190         


Tyr Ser Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly 
        195                 200                 205             


Phe Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile 
    210                 215                 220                 


Thr Arg Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro 
225                 230                 235                 240 


Gly Asp Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val 
                245                 250                 255     


Gly Tyr Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly 
            260                 265                 270         


Thr Ile Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr 
        275                 280                 285             


Lys Cys Thr Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr 
    290                 295                 300                 


Ser Asn Phe Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn 
305                 310                 315                 320 


Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe 
                325                 330                 335     


Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala 
            340                 345                 350         


Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys 
        355                 360                 365             


Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val 
    370                 375                 380                 


Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala 
385                 390                 395                 400 


Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp 
                405                 410                 415     


Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser 
            420                 425                 430         


Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser 
        435                 440                 445             


Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala 
    450                 455                 460                 


Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro 
465                 470                 475                 480 


Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro 
                485                 490                 495     


Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr 
            500                 505                 510         


Val Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val 
        515                 520                 525             


Asn Phe Asn Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser 
    530                 535                 540                 


Asn Lys Lys Phe Gln Pro His Gln Gln Phe Gly Arg Asp Ile Ala Asp 
545                 550                 555                 560 


Thr Thr Asp Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile 
                565                 570                 575     


Thr Pro Cys Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn 
            580                 585                 590         


Thr Ser Asn Gln Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu 
        595                 600                 605             


Val Pro Val Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val 
    610                 615                 620                 


Tyr Ser Thr Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile 
625                 630                 635                 640 


Gly Ala Glu His Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly 
                645                 650                 655     


Ala Gly Ile Cys Ala Ser Tyr Gln Thr Gln Thr Gly Ser Gly Gly Gly 
            660                 665                 670         


Gly Glu Ser Gln Val Arg Gln Gln Phe Ser Lys Asp Ile Glu Lys Leu 
        675                 680                 685             


Leu Asn Glu Gln Val Asn Lys Glu Met Gln Ser Ser Asn Leu Tyr Met 
    690                 695                 700                 


Ser Met Ser Ser Trp Cys Tyr Thr His Ser Leu Asp Gly Ala Gly Leu 
705                 710                 715                 720 


Phe Leu Phe Asp His Ala Ala Glu Glu Tyr Glu His Ala Lys Lys Leu 
                725                 730                 735     


Ile Ile Phe Leu Asn Glu Asn Asn Val Pro Val Gln Leu Thr Ser Ile 
            740                 745                 750         


Ser Ala Pro Glu His Lys Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys 
        755                 760                 765             


Ala Tyr Glu His Glu Gln His Ile Ser Glu Ser Ile Asn Asn Ile Val 
    770                 775                 780                 


Asp His Ala Ile Lys Ser Lys Asp His Ala Thr Phe Asn Phe Leu Gln 
785                 790                 795                 800 


Trp Tyr Val Ala Glu Gln His Glu Glu Glu Val Leu Phe Lys Asp Ile 
                805                 810                 815     


Leu Asp Lys Ile Glu Leu Ile Gly Asn Glu Asn His Gly Leu Tyr Leu 
            820                 825                 830         


Ala Asp Gln Tyr Val Lys Gly Ile Ala Lys Ser Arg Lys Ser Gly Ser 
        835                 840                 845             


<210> 116
<211> 848
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 116
Ser Ser Gln Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala 
1               5                   10                  15      


Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe 
            20                  25                  30          


Arg Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe 
        35                  40                  45              


Ser Asn Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly 
    50                  55                  60                  


Thr Lys Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr 
65                  70                  75                  80  


Phe Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly 
                85                  90                  95      


Thr Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala 
            100                 105                 110         


Thr Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro 
        115                 120                 125             


Phe Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser 
    130                 135                 140                 


Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val 
145                 150                 155                 160 


Ser Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys 
                165                 170                 175     


Asn Leu Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile 
            180                 185                 190         


Tyr Ser Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly 
        195                 200                 205             


Phe Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile 
    210                 215                 220                 


Thr Arg Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro 
225                 230                 235                 240 


Gly Asp Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val 
                245                 250                 255     


Gly Tyr Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly 
            260                 265                 270         


Thr Ile Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr 
        275                 280                 285             


Lys Cys Thr Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr 
    290                 295                 300                 


Ser Asn Phe Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn 
305                 310                 315                 320 


Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe 
                325                 330                 335     


Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala 
            340                 345                 350         


Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys 
        355                 360                 365             


Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val 
    370                 375                 380                 


Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala 
385                 390                 395                 400 


Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp 
                405                 410                 415     


Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser 
            420                 425                 430         


Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser 
        435                 440                 445             


Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala 
    450                 455                 460                 


Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro 
465                 470                 475                 480 


Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro 
                485                 490                 495     


Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr 
            500                 505                 510         


Val Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val 
        515                 520                 525             


Asn Phe Asn Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser 
    530                 535                 540                 


Asn Lys Lys Phe Leu Pro Asn Gln Thr Phe Gly Arg Asp Ile Ala Asp 
545                 550                 555                 560 


Thr Thr Asp Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile 
                565                 570                 575     


Thr Pro Cys Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn 
            580                 585                 590         


Thr Ser Asn Gln Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu 
        595                 600                 605             


Val Pro Val Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val 
    610                 615                 620                 


Tyr Ser Thr Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile 
625                 630                 635                 640 


Gly Ala Glu His Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly 
                645                 650                 655     


Ala Gly Ile Cys Ala Ser Tyr Gln Thr Gln Thr Gly Ser Gly Gly Gly 
            660                 665                 670         


Gly Glu Ser Gln Val Arg Gln Gln Phe Ser Lys Asp Ile Glu Lys Leu 
        675                 680                 685             


Leu Asn Glu Gln Val Asn Lys Glu Met Gln Ser Ser Asn Leu Tyr Met 
    690                 695                 700                 


Ser Met Ser Ser Trp Cys Tyr Thr His Ser Leu Asp Gly Ala Gly Leu 
705                 710                 715                 720 


Phe Leu Phe Asp His Ala Ala Glu Glu Tyr Glu His Ala Lys Lys Leu 
                725                 730                 735     


Ile Ile Phe Leu Asn Glu Asn Asn Val Pro Val Gln Leu Thr Ser Ile 
            740                 745                 750         


Ser Ala Pro Glu His Lys Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys 
        755                 760                 765             


Ala Tyr Glu His Glu Gln His Ile Ser Glu Ser Ile Asn Asn Ile Val 
    770                 775                 780                 


Asp His Ala Ile Lys Ser Lys Asp His Ala Thr Phe Asn Phe Leu Gln 
785                 790                 795                 800 


Trp Tyr Val Ala Glu Gln His Glu Glu Glu Val Leu Phe Lys Asp Ile 
                805                 810                 815     


Leu Asp Lys Ile Glu Leu Ile Gly Asn Glu Asn His Gly Leu Tyr Leu 
            820                 825                 830         


Ala Asp Gln Tyr Val Lys Gly Ile Ala Lys Ser Arg Lys Ser Gly Ser 
        835                 840                 845             


<210> 117
<211> 848
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 117
Ser Ser Gln Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala 
1               5                   10                  15      


Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe 
            20                  25                  30          


Arg Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe 
        35                  40                  45              


Ser Asn Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly 
    50                  55                  60                  


Thr Lys Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr 
65                  70                  75                  80  


Phe Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly 
                85                  90                  95      


Thr Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala 
            100                 105                 110         


Thr Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro 
        115                 120                 125             


Phe Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser 
    130                 135                 140                 


Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val 
145                 150                 155                 160 


Ser Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys 
                165                 170                 175     


Asn Leu Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile 
            180                 185                 190         


Tyr Ser Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly 
        195                 200                 205             


Phe Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile 
    210                 215                 220                 


Thr Arg Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro 
225                 230                 235                 240 


Gly Asp Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val 
                245                 250                 255     


Gly Tyr Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly 
            260                 265                 270         


Thr Ile Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr 
        275                 280                 285             


Lys Cys Thr Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr 
    290                 295                 300                 


Ser Asn Phe Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn 
305                 310                 315                 320 


Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe 
                325                 330                 335     


Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala 
            340                 345                 350         


Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys 
        355                 360                 365             


Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val 
    370                 375                 380                 


Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala 
385                 390                 395                 400 


Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp 
                405                 410                 415     


Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser 
            420                 425                 430         


Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser 
        435                 440                 445             


Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala 
    450                 455                 460                 


Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Arg Pro 
465                 470                 475                 480 


Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro 
                485                 490                 495     


Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr 
            500                 505                 510         


Val Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val 
        515                 520                 525             


Asn Phe Asn Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser 
    530                 535                 540                 


Asn Lys Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp 
545                 550                 555                 560 


Thr Thr Asp Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile 
                565                 570                 575     


Thr Pro Cys Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn 
            580                 585                 590         


Thr Ser Asn Gln Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu 
        595                 600                 605             


Val Pro Val Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val 
    610                 615                 620                 


Tyr Ser Thr Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile 
625                 630                 635                 640 


Gly Ala Glu His Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly 
                645                 650                 655     


Ala Gly Ile Cys Ala Ser Tyr Gln Thr Gln Thr Gly Ser Gly Gly Gly 
            660                 665                 670         


Gly Glu Ser Gln Val Arg Gln Gln Phe Ser Lys Asp Ile Glu Lys Leu 
        675                 680                 685             


Leu Asn Glu Gln Val Asn Lys Glu Met Gln Ser Ser Asn Leu Tyr Met 
    690                 695                 700                 


Ser Met Ser Ser Trp Cys Tyr Thr His Ser Leu Asp Gly Ala Gly Leu 
705                 710                 715                 720 


Phe Leu Phe Asp His Ala Ala Glu Glu Tyr Glu His Ala Lys Lys Leu 
                725                 730                 735     


Ile Ile Phe Leu Asn Glu Asn Asn Val Pro Val Gln Leu Thr Ser Ile 
            740                 745                 750         


Ser Ala Pro Glu His Lys Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys 
        755                 760                 765             


Ala Tyr Glu His Glu Gln His Ile Ser Glu Ser Ile Asn Asn Ile Val 
    770                 775                 780                 


Asp His Ala Ile Lys Ser Lys Asp His Ala Thr Phe Asn Phe Leu Gln 
785                 790                 795                 800 


Trp Tyr Val Ala Glu Gln His Glu Glu Glu Val Leu Phe Lys Asp Ile 
                805                 810                 815     


Leu Asp Lys Ile Glu Leu Ile Gly Asn Glu Asn His Gly Leu Tyr Leu 
            820                 825                 830         


Ala Asp Gln Tyr Val Lys Gly Ile Ala Lys Ser Arg Lys Ser Gly Ser 
        835                 840                 845             


<210> 118
<211> 848
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 118
Ser Ser Gln Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala 
1               5                   10                  15      


Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe 
            20                  25                  30          


Arg Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe 
        35                  40                  45              


Ser Asn Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly 
    50                  55                  60                  


Thr Lys Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr 
65                  70                  75                  80  


Phe Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly 
                85                  90                  95      


Thr Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala 
            100                 105                 110         


Thr Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro 
        115                 120                 125             


Phe Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser 
    130                 135                 140                 


Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val 
145                 150                 155                 160 


Ser Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys 
                165                 170                 175     


Asn Leu Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile 
            180                 185                 190         


Tyr Ser Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly 
        195                 200                 205             


Phe Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile 
    210                 215                 220                 


Thr Arg Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro 
225                 230                 235                 240 


Gly Asp Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val 
                245                 250                 255     


Gly Tyr Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly 
            260                 265                 270         


Thr Ile Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr 
        275                 280                 285             


Lys Cys Thr Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr 
    290                 295                 300                 


Ser Asn Phe Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn 
305                 310                 315                 320 


Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe 
                325                 330                 335     


Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala 
            340                 345                 350         


Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys 
        355                 360                 365             


Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val 
    370                 375                 380                 


Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala 
385                 390                 395                 400 


Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp 
                405                 410                 415     


Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser 
            420                 425                 430         


Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser 
        435                 440                 445             


Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala 
    450                 455                 460                 


Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Ala Pro 
465                 470                 475                 480 


Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro 
                485                 490                 495     


Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr 
            500                 505                 510         


Val Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val 
        515                 520                 525             


Asn Phe Asn Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser 
    530                 535                 540                 


Asn Lys Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp 
545                 550                 555                 560 


Thr Thr Asp Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile 
                565                 570                 575     


Thr Pro Cys Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn 
            580                 585                 590         


Thr Ser Asn Gln Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu 
        595                 600                 605             


Val Pro Val Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val 
    610                 615                 620                 


Tyr Ser Thr Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile 
625                 630                 635                 640 


Gly Ala Glu His Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly 
                645                 650                 655     


Ala Gly Ile Cys Ala Ser Tyr Gln Thr Gln Thr Gly Ser Gly Gly Gly 
            660                 665                 670         


Gly Glu Ser Gln Val Arg Gln Gln Phe Ser Lys Asp Ile Glu Lys Leu 
        675                 680                 685             


Leu Asn Glu Gln Val Asn Lys Glu Met Gln Ser Ser Asn Leu Tyr Met 
    690                 695                 700                 


Ser Met Ser Ser Trp Cys Tyr Thr His Ser Leu Asp Gly Ala Gly Leu 
705                 710                 715                 720 


Phe Leu Phe Asp His Ala Ala Glu Glu Tyr Glu His Ala Lys Lys Leu 
                725                 730                 735     


Ile Ile Phe Leu Asn Glu Asn Asn Val Pro Val Gln Leu Thr Ser Ile 
            740                 745                 750         


Ser Ala Pro Glu His Lys Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys 
        755                 760                 765             


Ala Tyr Glu His Glu Gln His Ile Ser Glu Ser Ile Asn Asn Ile Val 
    770                 775                 780                 


Asp His Ala Ile Lys Ser Lys Asp His Ala Thr Phe Asn Phe Leu Gln 
785                 790                 795                 800 


Trp Tyr Val Ala Glu Gln His Glu Glu Glu Val Leu Phe Lys Asp Ile 
                805                 810                 815     


Leu Asp Lys Ile Glu Leu Ile Gly Asn Glu Asn His Gly Leu Tyr Leu 
            820                 825                 830         


Ala Asp Gln Tyr Val Lys Gly Ile Ala Lys Ser Arg Lys Ser Gly Ser 
        835                 840                 845             


<210> 119
<211> 1314
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 119
Ser Ser Gln Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala 
1               5                   10                  15      


Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe 
            20                  25                  30          


Arg Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe 
        35                  40                  45              


Ser Asn Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly 
    50                  55                  60                  


Thr Lys Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr 
65                  70                  75                  80  


Phe Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly 
                85                  90                  95      


Thr Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala 
            100                 105                 110         


Thr Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro 
        115                 120                 125             


Phe Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser 
    130                 135                 140                 


Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val 
145                 150                 155                 160 


Ser Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys 
                165                 170                 175     


Asn Leu Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile 
            180                 185                 190         


Tyr Ser Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly 
        195                 200                 205             


Phe Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile 
    210                 215                 220                 


Thr Arg Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro 
225                 230                 235                 240 


Gly Asp Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val 
                245                 250                 255     


Gly Tyr Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly 
            260                 265                 270         


Thr Ile Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr 
        275                 280                 285             


Lys Cys Thr Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr 
    290                 295                 300                 


Ser Asn Phe Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn 
305                 310                 315                 320 


Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe 
                325                 330                 335     


Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala 
            340                 345                 350         


Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys 
        355                 360                 365             


Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val 
    370                 375                 380                 


Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala 
385                 390                 395                 400 


Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp 
                405                 410                 415     


Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser 
            420                 425                 430         


Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser 
        435                 440                 445             


Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala 
    450                 455                 460                 


Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro 
465                 470                 475                 480 


Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro 
                485                 490                 495     


Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr 
            500                 505                 510         


Val Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val 
        515                 520                 525             


Asn Phe Asn Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser 
    530                 535                 540                 


Asn Lys Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp 
545                 550                 555                 560 


Thr Thr Asp Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile 
                565                 570                 575     


Thr Pro Cys Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn 
            580                 585                 590         


Thr Ser Asn Gln Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu 
        595                 600                 605             


Val Pro Val Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val 
    610                 615                 620                 


Tyr Ser Thr Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile 
625                 630                 635                 640 


Gly Ala Glu His Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly 
                645                 650                 655     


Ala Gly Ile Cys Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro Gly Ser 
            660                 665                 670         


Ala Ser Ser Val Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu 
        675                 680                 685             


Gly Ala Glu Asn Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro 
    690                 695                 700                 


Thr Asn Phe Thr Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met 
705                 710                 715                 720 


Thr Lys Thr Ser Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr 
                725                 730                 735     


Glu Cys Ser Asn Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu 
            740                 745                 750         


Asn Arg Ala Leu Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln 
        755                 760                 765             


Glu Val Phe Ala Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys 
    770                 775                 780                 


Asp Phe Gly Gly Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys 
785                 790                 795                 800 


Pro Ser Lys Arg Ser Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr 
                805                 810                 815     


Leu Ala Asp Ala Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp 
            820                 825                 830         


Ile Ala Ala Arg Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr 
        835                 840                 845             


Val Leu Pro Pro Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser 
    850                 855                 860                 


Ala Leu Leu Ala Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly 
865                 870                 875                 880 


Ala Ala Leu Gln Ile Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn 
                885                 890                 895     


Gly Ile Gly Val Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile 
            900                 905                 910         


Ala Asn Gln Phe Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser 
        915                 920                 925             


Ser Thr Ala Ser Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn 
    930                 935                 940                 


Ala Gln Ala Leu Asn Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly 
945                 950                 955                 960 


Ala Ile Ser Ser Val Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val 
                965                 970                 975     


Glu Ala Glu Val Gln Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser 
            980                 985                 990         


Leu Gln Thr Tyr Val Thr Gln Gln  Leu Ile Arg Ala Ala  Glu Ile Arg 
        995                 1000                 1005             


Ala Ser  Ala Asn Leu Ala Ala  Thr Lys Met Ser Glu  Cys Val Leu 
    1010                 1015                 1020             


Gly Gln  Ser Lys Arg Val Asp  Phe Cys Gly Lys Gly  Tyr His Leu 
    1025                 1030                 1035             


Met Ser  Phe Pro Gln Ser Ala  Pro His Gly Val Val  Phe Leu His 
    1040                 1045                 1050             


Val Thr  Tyr Val Pro Ala Gln  Glu Lys Asn Phe Thr  Thr Ala Pro 
    1055                 1060                 1065             


Ala Ile  Cys His Asp Gly Lys  Ala His Phe Pro Arg  Glu Gly Val 
    1070                 1075                 1080             


Phe Val  Ser Asn Gly Thr His  Trp Phe Val Thr Gln  Arg Asn Phe 
    1085                 1090                 1095             


Tyr Glu  Pro Gln Ile Ile Thr  Thr Asp Asn Thr Phe  Val Ser Gly 
    1100                 1105                 1110             


Asn Cys  Asp Val Val Ile Gly  Ile Val Asn Asn Thr  Val Tyr Asp 
    1115                 1120                 1125             


Pro Leu  Gln Pro Glu Leu Asp  Ser Phe Lys Glu Glu  Leu Asp Lys 
    1130                 1135                 1140             


Gly Ser  Gly Gly Ser Gly Asp  Ile Ile Lys Leu Leu  Asn Glu Gln 
    1145                 1150                 1155             


Val Asn  Lys Glu Met Gln Ser  Ser Asn Leu Tyr Met  Ser Met Ser 
    1160                 1165                 1170             


Ser Trp  Cys Tyr Thr His Ser  Leu Asp Gly Ala Gly  Leu Phe Leu 
    1175                 1180                 1185             


Phe Asp  His Ala Ala Glu Glu  Tyr Glu His Ala Lys  Lys Leu Ile 
    1190                 1195                 1200             


Ile Phe  Leu Asn Glu Asn Asn  Val Pro Val Gln Leu  Thr Ser Ile 
    1205                 1210                 1215             


Ser Ala  Pro Glu His Lys Phe  Glu Gly Leu Thr Gln  Ile Phe Gln 
    1220                 1225                 1230             


Lys Ala  Tyr Glu His Glu Gln  His Ile Ser Glu Ser  Ile Asn Asn 
    1235                 1240                 1245             


Ile Val  Asp His Ala Ile Lys  Ser Lys Asp His Ala  Thr Phe Asn 
    1250                 1255                 1260             


Phe Leu  Gln Trp Tyr Val Ala  Glu Gln His Glu Glu  Glu Val Leu 
    1265                 1270                 1275             


Phe Lys  Asp Ile Leu Asp Lys  Ile Glu Leu Ile Gly  Asn Glu Asn 
    1280                 1285                 1290             


His Gly  Leu Tyr Leu Ala Asp  Gln Tyr Val Lys Gly  Ile Ala Lys 
    1295                 1300                 1305             


Ser Arg  Lys Ser Gly Ser 
    1310                 


<210> 120
<211> 694
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 120
His His His His His His His His Gly Pro Leu Glu Val Leu Phe Gln 
1               5                   10                  15      


Gly Pro Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala 
            20                  25                  30          


Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn 
        35                  40                  45              


Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr 
    50                  55                  60                  


Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe 
65                  70                  75                  80  


Thr Asn Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg 
                85                  90                  95      


Gln Ile Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys 
            100                 105                 110         


Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn 
        115                 120                 125             


Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe 
    130                 135                 140                 


Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile 
145                 150                 155                 160 


Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys 
                165                 170                 175     


Tyr Phe Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly 
            180                 185                 190         


Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala 
        195                 200                 205             


Pro Ala Thr Val Cys Gly Pro Gly Ser Gly Gly Ser Gly Ser Ser Gln 
    210                 215                 220                 


Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn 
225                 230                 235                 240 


Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser 
                245                 250                 255     


Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val 
            260                 265                 270         


Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg 
        275                 280                 285             


Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser 
    290                 295                 300                 


Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu 
305                 310                 315                 320 


Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val 
                325                 330                 335     


Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly 
            340                 345                 350         


Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg 
        355                 360                 365             


Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro 
    370                 375                 380                 


Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg 
385                 390                 395                 400 


Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys 
                405                 410                 415     


His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala 
            420                 425                 430         


Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe 
        435                 440                 445             


Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser 
    450                 455                 460                 


Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu 
465                 470                 475                 480 


Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr 
                485                 490                 495     


Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr 
            500                 505                 510         


Leu Gly Ser Gly Gly Gly Gly Glu Ser Gln Val Arg Gln Gln Phe Ser 
        515                 520                 525             


Lys Asp Ile Glu Lys Leu Leu Asn Glu Gln Val Asn Lys Glu Met Gln 
    530                 535                 540                 


Ser Ser Asn Leu Tyr Met Ser Met Ser Ser Trp Cys Tyr Thr His Ser 
545                 550                 555                 560 


Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp His Ala Ala Glu Glu Tyr 
                565                 570                 575     


Glu His Ala Lys Lys Leu Ile Ile Phe Leu Asn Glu Asn Asn Val Pro 
            580                 585                 590         


Val Gln Leu Thr Ser Ile Ser Ala Pro Glu His Lys Phe Glu Gly Leu 
        595                 600                 605             


Thr Gln Ile Phe Gln Lys Ala Tyr Glu His Glu Gln His Ile Ser Glu 
    610                 615                 620                 


Ser Ile Asn Asn Ile Val Asp His Ala Ile Lys Ser Lys Asp His Ala 
625                 630                 635                 640 


Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala Glu Gln His Glu Glu Glu 
                645                 650                 655     


Val Leu Phe Lys Asp Ile Leu Asp Lys Ile Glu Leu Ile Gly Asn Glu 
            660                 665                 670         


Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr Val Lys Gly Ile Ala Lys 
        675                 680                 685             


Ser Arg Lys Ser Gly Ser 
    690                 


<210> 121
<211> 694
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 121
His His His His His His His His Gly Pro Leu Glu Val Leu Phe Gln 
1               5                   10                  15      


Gly Pro Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala 
            20                  25                  30          


Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn 
        35                  40                  45              


Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr 
    50                  55                  60                  


Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe 
65                  70                  75                  80  


Thr Asn Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg 
                85                  90                  95      


Gln Ile Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys 
            100                 105                 110         


Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn 
        115                 120                 125             


Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe 
    130                 135                 140                 


Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile 
145                 150                 155                 160 


Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys 
                165                 170                 175     


Tyr Arg Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly 
            180                 185                 190         


Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala 
        195                 200                 205             


Pro Ala Thr Val Cys Gly Pro Gly Ser Gly Gly Ser Gly Ser Ser Gln 
    210                 215                 220                 


Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn 
225                 230                 235                 240 


Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser 
                245                 250                 255     


Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val 
            260                 265                 270         


Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg 
        275                 280                 285             


Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser 
    290                 295                 300                 


Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu 
305                 310                 315                 320 


Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val 
                325                 330                 335     


Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly 
            340                 345                 350         


Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg 
        355                 360                 365             


Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro 
    370                 375                 380                 


Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg 
385                 390                 395                 400 


Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys 
                405                 410                 415     


His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala 
            420                 425                 430         


Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe 
        435                 440                 445             


Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser 
    450                 455                 460                 


Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu 
465                 470                 475                 480 


Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr 
                485                 490                 495     


Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr 
            500                 505                 510         


Leu Gly Ser Gly Gly Gly Gly Glu Ser Gln Val Arg Gln Gln Phe Ser 
        515                 520                 525             


Lys Asp Ile Glu Lys Leu Leu Asn Glu Gln Val Asn Lys Glu Met Gln 
    530                 535                 540                 


Ser Ser Asn Leu Tyr Met Ser Met Ser Ser Trp Cys Tyr Thr His Ser 
545                 550                 555                 560 


Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp His Ala Ala Glu Glu Tyr 
                565                 570                 575     


Glu His Ala Lys Lys Leu Ile Ile Phe Leu Asn Glu Asn Asn Val Pro 
            580                 585                 590         


Val Gln Leu Thr Ser Ile Ser Ala Pro Glu His Lys Phe Glu Gly Leu 
        595                 600                 605             


Thr Gln Ile Phe Gln Lys Ala Tyr Glu His Glu Gln His Ile Ser Glu 
    610                 615                 620                 


Ser Ile Asn Asn Ile Val Asp His Ala Ile Lys Ser Lys Asp His Ala 
625                 630                 635                 640 


Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala Glu Gln His Glu Glu Glu 
                645                 650                 655     


Val Leu Phe Lys Asp Ile Leu Asp Lys Ile Glu Leu Ile Gly Asn Glu 
            660                 665                 670         


Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr Val Lys Gly Ile Ala Lys 
        675                 680                 685             


Ser Arg Lys Ser Gly Ser 
    690                 


<210> 122
<211> 694
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 122
His His His His His His His His Gly Pro Leu Glu Val Leu Phe Gln 
1               5                   10                  15      


Gly Pro Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala 
            20                  25                  30          


Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn 
        35                  40                  45              


Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr 
    50                  55                  60                  


Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe 
65                  70                  75                  80  


Thr Asn Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg 
                85                  90                  95      


Gln Ile Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys 
            100                 105                 110         


Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn 
        115                 120                 125             


Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe 
    130                 135                 140                 


Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile 
145                 150                 155                 160 


Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys 
                165                 170                 175     


Tyr Ala Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly 
            180                 185                 190         


Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala 
        195                 200                 205             


Pro Ala Thr Val Cys Gly Pro Gly Ser Gly Gly Ser Gly Ser Ser Gln 
    210                 215                 220                 


Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn 
225                 230                 235                 240 


Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser 
                245                 250                 255     


Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val 
            260                 265                 270         


Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg 
        275                 280                 285             


Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser 
    290                 295                 300                 


Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu 
305                 310                 315                 320 


Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val 
                325                 330                 335     


Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly 
            340                 345                 350         


Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg 
        355                 360                 365             


Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro 
    370                 375                 380                 


Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg 
385                 390                 395                 400 


Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys 
                405                 410                 415     


His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala 
            420                 425                 430         


Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe 
        435                 440                 445             


Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser 
    450                 455                 460                 


Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu 
465                 470                 475                 480 


Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr 
                485                 490                 495     


Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr 
            500                 505                 510         


Leu Gly Ser Gly Gly Gly Gly Glu Ser Gln Val Arg Gln Gln Phe Ser 
        515                 520                 525             


Lys Asp Ile Glu Lys Leu Leu Asn Glu Gln Val Asn Lys Glu Met Gln 
    530                 535                 540                 


Ser Ser Asn Leu Tyr Met Ser Met Ser Ser Trp Cys Tyr Thr His Ser 
545                 550                 555                 560 


Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp His Ala Ala Glu Glu Tyr 
                565                 570                 575     


Glu His Ala Lys Lys Leu Ile Ile Phe Leu Asn Glu Asn Asn Val Pro 
            580                 585                 590         


Val Gln Leu Thr Ser Ile Ser Ala Pro Glu His Lys Phe Glu Gly Leu 
        595                 600                 605             


Thr Gln Ile Phe Gln Lys Ala Tyr Glu His Glu Gln His Ile Ser Glu 
    610                 615                 620                 


Ser Ile Asn Asn Ile Val Asp His Ala Ile Lys Ser Lys Asp His Ala 
625                 630                 635                 640 


Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala Glu Gln His Glu Glu Glu 
                645                 650                 655     


Val Leu Phe Lys Asp Ile Leu Asp Lys Ile Glu Leu Ile Gly Asn Glu 
            660                 665                 670         


Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr Val Lys Gly Ile Ala Lys 
        675                 680                 685             


Ser Arg Lys Ser Gly Ser 
    690                 


<210> 123
<211> 694
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 123
His His His His His His His His Gly Pro Leu Glu Val Leu Phe Gln 
1               5                   10                  15      


Gly Pro Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala 
            20                  25                  30          


Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn 
        35                  40                  45              


Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr 
    50                  55                  60                  


Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe 
65                  70                  75                  80  


Thr Asn Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg 
                85                  90                  95      


Gln Ile Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys 
            100                 105                 110         


Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn 
        115                 120                 125             


Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe 
    130                 135                 140                 


Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile 
145                 150                 155                 160 


Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys 
                165                 170                 175     


Tyr Phe Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly 
            180                 185                 190         


Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe Glu Asn Lys Ser Ala 
        195                 200                 205             


Pro Ala Thr Val Cys Gly Pro Gly Ser Gly Gly Ser Gly Ser Ser Gln 
    210                 215                 220                 


Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn 
225                 230                 235                 240 


Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser 
                245                 250                 255     


Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val 
            260                 265                 270         


Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg 
        275                 280                 285             


Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser 
    290                 295                 300                 


Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu 
305                 310                 315                 320 


Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val 
                325                 330                 335     


Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly 
            340                 345                 350         


Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg 
        355                 360                 365             


Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro 
    370                 375                 380                 


Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg 
385                 390                 395                 400 


Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys 
                405                 410                 415     


His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala 
            420                 425                 430         


Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe 
        435                 440                 445             


Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser 
    450                 455                 460                 


Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu 
465                 470                 475                 480 


Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr 
                485                 490                 495     


Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr 
            500                 505                 510         


Leu Gly Ser Gly Gly Gly Gly Glu Ser Gln Val Arg Gln Gln Phe Ser 
        515                 520                 525             


Lys Asp Ile Glu Lys Leu Leu Asn Glu Gln Val Asn Lys Glu Met Gln 
    530                 535                 540                 


Ser Ser Asn Leu Tyr Met Ser Met Ser Ser Trp Cys Tyr Thr His Ser 
545                 550                 555                 560 


Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp His Ala Ala Glu Glu Tyr 
                565                 570                 575     


Glu His Ala Lys Lys Leu Ile Ile Phe Leu Asn Glu Asn Asn Val Pro 
            580                 585                 590         


Val Gln Leu Thr Ser Ile Ser Ala Pro Glu His Lys Phe Glu Gly Leu 
        595                 600                 605             


Thr Gln Ile Phe Gln Lys Ala Tyr Glu His Glu Gln His Ile Ser Glu 
    610                 615                 620                 


Ser Ile Asn Asn Ile Val Asp His Ala Ile Lys Ser Lys Asp His Ala 
625                 630                 635                 640 


Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala Glu Gln His Glu Glu Glu 
                645                 650                 655     


Val Leu Phe Lys Asp Ile Leu Asp Lys Ile Glu Leu Ile Gly Asn Glu 
            660                 665                 670         


Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr Val Lys Gly Ile Ala Lys 
        675                 680                 685             


Ser Arg Lys Ser Gly Ser 
    690                 


<210> 124
<211> 694
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 124
His His His His His His His His Gly Pro Leu Glu Val Leu Phe Gln 
1               5                   10                  15      


Gly Pro Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala 
            20                  25                  30          


Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn 
        35                  40                  45              


Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr 
    50                  55                  60                  


Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe 
65                  70                  75                  80  


Thr Asn Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg 
                85                  90                  95      


Gln Ile Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys 
            100                 105                 110         


Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn 
        115                 120                 125             


Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe 
    130                 135                 140                 


Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile 
145                 150                 155                 160 


Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys 
                165                 170                 175     


Tyr Phe Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly 
            180                 185                 190         


Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Arg His Ala 
        195                 200                 205             


Pro Ala Thr Val Cys Gly Pro Gly Ser Gly Gly Ser Gly Ser Ser Gln 
    210                 215                 220                 


Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn 
225                 230                 235                 240 


Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser 
                245                 250                 255     


Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val 
            260                 265                 270         


Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg 
        275                 280                 285             


Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser 
    290                 295                 300                 


Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu 
305                 310                 315                 320 


Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val 
                325                 330                 335     


Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly 
            340                 345                 350         


Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg 
        355                 360                 365             


Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro 
    370                 375                 380                 


Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg 
385                 390                 395                 400 


Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys 
                405                 410                 415     


His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala 
            420                 425                 430         


Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe 
        435                 440                 445             


Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser 
    450                 455                 460                 


Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu 
465                 470                 475                 480 


Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr 
                485                 490                 495     


Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr 
            500                 505                 510         


Leu Gly Ser Gly Gly Gly Gly Glu Ser Gln Val Arg Gln Gln Phe Ser 
        515                 520                 525             


Lys Asp Ile Glu Lys Leu Leu Asn Glu Gln Val Asn Lys Glu Met Gln 
    530                 535                 540                 


Ser Ser Asn Leu Tyr Met Ser Met Ser Ser Trp Cys Tyr Thr His Ser 
545                 550                 555                 560 


Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp His Ala Ala Glu Glu Tyr 
                565                 570                 575     


Glu His Ala Lys Lys Leu Ile Ile Phe Leu Asn Glu Asn Asn Val Pro 
            580                 585                 590         


Val Gln Leu Thr Ser Ile Ser Ala Pro Glu His Lys Phe Glu Gly Leu 
        595                 600                 605             


Thr Gln Ile Phe Gln Lys Ala Tyr Glu His Glu Gln His Ile Ser Glu 
    610                 615                 620                 


Ser Ile Asn Asn Ile Val Asp His Ala Ile Lys Ser Lys Asp His Ala 
625                 630                 635                 640 


Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala Glu Gln His Glu Glu Glu 
                645                 650                 655     


Val Leu Phe Lys Asp Ile Leu Asp Lys Ile Glu Leu Ile Gly Asn Glu 
            660                 665                 670         


Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr Val Lys Gly Ile Ala Lys 
        675                 680                 685             


Ser Arg Lys Ser Gly Ser 
    690                 


<210> 125
<211> 396
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 125
His His His His His His His His Gly Pro Leu Glu Val Leu Phe Gln 
1               5                   10                  15      


Gly Pro Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala 
            20                  25                  30          


Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn 
        35                  40                  45              


Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr 
    50                  55                  60                  


Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe 
65                  70                  75                  80  


Thr Asn Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg 
                85                  90                  95      


Gln Ile Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys 
            100                 105                 110         


Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn 
        115                 120                 125             


Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe 
    130                 135                 140                 


Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile 
145                 150                 155                 160 


Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys 
                165                 170                 175     


Tyr Ala Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly 
            180                 185                 190         


Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe Glu Asn Lys Ser Ala 
        195                 200                 205             


Pro Ala Thr Val Cys Gly Pro Gly Ser Gly Gly Gly Gly Glu Ser Gln 
    210                 215                 220                 


Val Arg Gln Gln Phe Ser Lys Asp Ile Glu Lys Leu Leu Asn Glu Gln 
225                 230                 235                 240 


Val Asn Lys Glu Met Gln Ser Ser Asn Leu Tyr Met Ser Met Ser Ser 
                245                 250                 255     


Trp Cys Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp 
            260                 265                 270         


His Ala Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe Leu 
        275                 280                 285             


Asn Glu Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro Glu 
    290                 295                 300                 


His Lys Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu His 
305                 310                 315                 320 


Glu Gln His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala Ile 
                325                 330                 335     


Lys Ser Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala 
            340                 345                 350         


Glu Gln His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys Ile 
        355                 360                 365             


Glu Leu Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr 
    370                 375                 380                 


Val Lys Gly Ile Ala Lys Ser Arg Lys Ser Gly Ser 
385                 390                 395     


<210> 126
<211> 396
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 126
His His His His His His His His Gly Pro Leu Glu Val Leu Phe Gln 
1               5                   10                  15      


Gly Pro Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala 
            20                  25                  30          


Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn 
        35                  40                  45              


Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr 
    50                  55                  60                  


Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe 
65                  70                  75                  80  


Thr Asn Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg 
                85                  90                  95      


Gln Ile Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys 
            100                 105                 110         


Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn 
        115                 120                 125             


Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe 
    130                 135                 140                 


Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile 
145                 150                 155                 160 


Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys 
                165                 170                 175     


Tyr Ala Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly 
            180                 185                 190         


Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Arg His Ala 
        195                 200                 205             


Pro Ala Thr Val Cys Gly Pro Gly Ser Gly Gly Gly Gly Glu Ser Gln 
    210                 215                 220                 


Val Arg Gln Gln Phe Ser Lys Asp Ile Glu Lys Leu Leu Asn Glu Gln 
225                 230                 235                 240 


Val Asn Lys Glu Met Gln Ser Ser Asn Leu Tyr Met Ser Met Ser Ser 
                245                 250                 255     


Trp Cys Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp 
            260                 265                 270         


His Ala Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe Leu 
        275                 280                 285             


Asn Glu Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro Glu 
    290                 295                 300                 


His Lys Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu His 
305                 310                 315                 320 


Glu Gln His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala Ile 
                325                 330                 335     


Lys Ser Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala 
            340                 345                 350         


Glu Gln His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys Ile 
        355                 360                 365             


Glu Leu Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr 
    370                 375                 380                 


Val Lys Gly Ile Ala Lys Ser Arg Lys Ser Gly Ser 
385                 390                 395     


<210> 127
<211> 396
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 127
His His His His His His His His Gly Pro Leu Glu Val Leu Phe Gln 
1               5                   10                  15      


Gly Pro Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala 
            20                  25                  30          


Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn 
        35                  40                  45              


Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr 
    50                  55                  60                  


Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe 
65                  70                  75                  80  


Thr Asn Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg 
                85                  90                  95      


Gln Ile Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys 
            100                 105                 110         


Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn 
        115                 120                 125             


Leu Asp Ser Lys Val Gly Gly Asn Lys Asn Tyr Leu Tyr Arg Arg Phe 
    130                 135                 140                 


Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile 
145                 150                 155                 160 


Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys 
                165                 170                 175     


Tyr Arg Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly 
            180                 185                 190         


Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe Glu Asn Lys Ser Ala 
        195                 200                 205             


Pro Ala Thr Val Cys Gly Pro Gly Ser Gly Gly Gly Gly Glu Ser Gln 
    210                 215                 220                 


Val Arg Gln Gln Phe Ser Lys Asp Ile Glu Lys Leu Leu Asn Glu Gln 
225                 230                 235                 240 


Val Asn Lys Glu Met Gln Ser Ser Asn Leu Tyr Met Ser Met Ser Ser 
                245                 250                 255     


Trp Cys Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp 
            260                 265                 270         


His Ala Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe Leu 
        275                 280                 285             


Asn Glu Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro Glu 
    290                 295                 300                 


His Lys Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu His 
305                 310                 315                 320 


Glu Gln His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala Ile 
                325                 330                 335     


Lys Ser Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala 
            340                 345                 350         


Glu Gln His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys Ile 
        355                 360                 365             


Glu Leu Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr 
    370                 375                 380                 


Val Lys Gly Ile Ala Lys Ser Arg Lys Ser Gly Ser 
385                 390                 395     


<210> 128
<211> 396
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 128
His His His His His His His His Gly Pro Leu Glu Val Leu Phe Gln 
1               5                   10                  15      


Gly Pro Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala 
            20                  25                  30          


Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn 
        35                  40                  45              


Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr 
    50                  55                  60                  


Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe 
65                  70                  75                  80  


Thr Asn Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg 
                85                  90                  95      


Gln Ile Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys 
            100                 105                 110         


Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn 
        115                 120                 125             


Leu Asp Ser Lys Val Gly Gly Asn Lys Asn Tyr Leu Tyr Arg Arg Phe 
    130                 135                 140                 


Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile 
145                 150                 155                 160 


Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys 
                165                 170                 175     


Tyr Arg Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly 
            180                 185                 190         


Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Arg His Ala 
        195                 200                 205             


Pro Ala Thr Val Cys Gly Pro Gly Ser Gly Gly Gly Gly Glu Ser Gln 
    210                 215                 220                 


Val Arg Gln Gln Phe Ser Lys Asp Ile Glu Lys Leu Leu Asn Glu Gln 
225                 230                 235                 240 


Val Asn Lys Glu Met Gln Ser Ser Asn Leu Tyr Met Ser Met Ser Ser 
                245                 250                 255     


Trp Cys Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp 
            260                 265                 270         


His Ala Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe Leu 
        275                 280                 285             


Asn Glu Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro Glu 
    290                 295                 300                 


His Lys Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu His 
305                 310                 315                 320 


Glu Gln His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala Ile 
                325                 330                 335     


Lys Ser Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala 
            340                 345                 350         


Glu Gln His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys Ile 
        355                 360                 365             


Glu Leu Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr 
    370                 375                 380                 


Val Lys Gly Ile Ala Lys Ser Arg Lys Ser Gly Ser 
385                 390                 395     


<210> 129
<211> 396
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 129
His His His His His His His His Gly Pro Leu Glu Val Leu Phe Gln 
1               5                   10                  15      


Gly Pro Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala 
            20                  25                  30          


Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn 
        35                  40                  45              


Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr 
    50                  55                  60                  


Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe 
65                  70                  75                  80  


Thr Asn Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg 
                85                  90                  95      


Gln Ile Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys 
            100                 105                 110         


Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn 
        115                 120                 125             


Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Arg Arg Leu Phe 
    130                 135                 140                 


Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile 
145                 150                 155                 160 


Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys 
                165                 170                 175     


Tyr Phe Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly 
            180                 185                 190         


Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe Glu Asn Lys Ser Ala 
        195                 200                 205             


Pro Ala Thr Val Cys Gly Pro Gly Ser Gly Gly Gly Gly Glu Ser Gln 
    210                 215                 220                 


Val Arg Gln Gln Phe Ser Lys Asp Ile Glu Lys Leu Leu Asn Glu Gln 
225                 230                 235                 240 


Val Asn Lys Glu Met Gln Ser Ser Asn Leu Tyr Met Ser Met Ser Ser 
                245                 250                 255     


Trp Cys Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp 
            260                 265                 270         


His Ala Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe Leu 
        275                 280                 285             


Asn Glu Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro Glu 
    290                 295                 300                 


His Lys Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu His 
305                 310                 315                 320 


Glu Gln His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala Ile 
                325                 330                 335     


Lys Ser Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala 
            340                 345                 350         


Glu Gln His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys Ile 
        355                 360                 365             


Glu Leu Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr 
    370                 375                 380                 


Val Lys Gly Ile Ala Lys Ser Arg Lys Ser Gly Ser 
385                 390                 395     


<210> 130
<211> 396
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 130
His His His His His His His His Gly Pro Leu Glu Val Leu Phe Gln 
1               5                   10                  15      


Gly Pro Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala 
            20                  25                  30          


Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn 
        35                  40                  45              


Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr 
    50                  55                  60                  


Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe 
65                  70                  75                  80  


Thr Asn Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg 
                85                  90                  95      


Gln Ile Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys 
            100                 105                 110         


Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn 
        115                 120                 125             


Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Arg Arg Leu Phe 
    130                 135                 140                 


Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile 
145                 150                 155                 160 


Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys 
                165                 170                 175     


Tyr Phe Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly 
            180                 185                 190         


Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Arg His Ala 
        195                 200                 205             


Pro Ala Thr Val Cys Gly Pro Gly Ser Gly Gly Gly Gly Glu Ser Gln 
    210                 215                 220                 


Val Arg Gln Gln Phe Ser Lys Asp Ile Glu Lys Leu Leu Asn Glu Gln 
225                 230                 235                 240 


Val Asn Lys Glu Met Gln Ser Ser Asn Leu Tyr Met Ser Met Ser Ser 
                245                 250                 255     


Trp Cys Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp 
            260                 265                 270         


His Ala Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe Leu 
        275                 280                 285             


Asn Glu Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro Glu 
    290                 295                 300                 


His Lys Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu His 
305                 310                 315                 320 


Glu Gln His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala Ile 
                325                 330                 335     


Lys Ser Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala 
            340                 345                 350         


Glu Gln His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys Ile 
        355                 360                 365             


Glu Leu Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr 
    370                 375                 380                 


Val Lys Gly Ile Ala Lys Ser Arg Lys Ser Gly Ser 
385                 390                 395     


<210> 131
<211> 1271
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 131
Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser 
1               5                   10                  15      


Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val 
            20                  25                  30          


Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr 
        35                  40                  45              


Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe 
    50                  55                  60                  


Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr 
65                  70                  75                  80  


Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp 
                85                  90                  95      


Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val 
            100                 105                 110         


Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val 
        115                 120                 125             


Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val 
    130                 135                 140                 


Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe 
145                 150                 155                 160 


Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu 
                165                 170                 175     


Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His 
            180                 185                 190         


Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu 
        195                 200                 205             


Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln 
    210                 215                 220                 


Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser 
225                 230                 235                 240 


Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln 
                245                 250                 255     


Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp 
            260                 265                 270         


Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu 
        275                 280                 285             


Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg 
    290                 295                 300                 


Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu 
305                 310                 315                 320 


Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr 
                325                 330                 335     


Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val 
            340                 345                 350         


Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser 
        355                 360                 365             


Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser 
    370                 375                 380                 


Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr 
385                 390                 395                 400 


Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly 
                405                 410                 415     


Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly 
            420                 425                 430         


Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro 
        435                 440                 445             


Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro 
    450                 455                 460                 


Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr 
465                 470                 475                 480 


Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val 
                485                 490                 495     


Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro 
            500                 505                 510         


Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe 
        515                 520                 525             


Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe 
    530                 535                 540                 


Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala 
545                 550                 555                 560 


Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser 
                565                 570                 575     


Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln 
            580                 585                 590         


Val Ala Val Leu Tyr Gln Gly Val Asn Cys Thr Glu Val Pro Val Ala 
        595                 600                 605             


Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly 
    610                 615                 620                 


Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His 
625                 630                 635                 640 


Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys 
                645                 650                 655     


Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro Gly Ser Ala Ser Ser Val 
            660                 665                 670         


Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn 
        675                 680                 685             


Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr 
    690                 695                 700                 


Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser 
705                 710                 715                 720 


Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn 
                725                 730                 735     


Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu 
            740                 745                 750         


Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala 
        755                 760                 765             


Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly 
    770                 775                 780                 


Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg 
785                 790                 795                 800 


Ser Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala 
                805                 810                 815     


Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg 
            820                 825                 830         


Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro 
        835                 840                 845             


Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala 
    850                 855                 860                 


Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln 
865                 870                 875                 880 


Ile Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val 
                885                 890                 895     


Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe 
            900                 905                 910         


Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser 
        915                 920                 925             


Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu 
    930                 935                 940                 


Asn Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser 
945                 950                 955                 960 


Val Leu Asn Asp Ile Leu Ser Arg Leu Asp Pro Pro Glu Ala Glu Val 
                965                 970                 975     


Gln Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser Leu Gln Thr Tyr 
            980                 985                 990         


Val Thr Gln Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
        995                 1000                 1005             


Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1010                 1015                 1020             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1025                 1030                 1035             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1040                 1045                 1050             


Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1055                 1060                 1065             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1070                 1075                 1080             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1085                 1090                 1095             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1100                 1105                 1110             


Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro 
    1115                 1120                 1125             


Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Tyr  Phe Lys Asn 
    1130                 1135                 1140             


His Thr  Ser Pro Asp Val Asp  Leu Gly Asp Ile Ser  Gly Ile Asn 
    1145                 1150                 1155             


Ala Ser  Val Val Asn Ile Gln  Lys Glu Ile Asp Arg  Leu Asn Glu 
    1160                 1165                 1170             


Val Ala  Lys Asn Leu Asn Glu  Ser Leu Ile Asp Leu  Gln Glu Leu 
    1175                 1180                 1185             


Gly Lys  Tyr Glu Gln Gly Ser  Gly Tyr Ile Pro Glu  Ala Pro Arg 
    1190                 1195                 1200             


Asp Gly  Gln Ala Tyr Val Arg  Lys Asp Gly Glu Trp  Val Leu Leu 
    1205                 1210                 1215             


Ser Thr  Phe Leu Gly Leu Glu  Val Leu Phe Gln Gly  Pro Ser Ala 
    1220                 1225                 1230             


Trp Ser  His Pro Gln Phe Glu  Lys Gly Gly Gly Ser  Gly Gly Gly 
    1235                 1240                 1245             


Ser Gly  Gly Ser Ala Trp Ser  His Pro Gln Phe Glu  Lys Gly Ser 
    1250                 1255                 1260             


His His  His His His His His  His 
    1265                 1270     


<210> 132
<211> 1271
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 132
Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser 
1               5                   10                  15      


Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val 
            20                  25                  30          


Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr 
        35                  40                  45              


Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe 
    50                  55                  60                  


Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr 
65                  70                  75                  80  


Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp 
                85                  90                  95      


Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val 
            100                 105                 110         


Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val 
        115                 120                 125             


Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val 
    130                 135                 140                 


Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe 
145                 150                 155                 160 


Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu 
                165                 170                 175     


Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His 
            180                 185                 190         


Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu 
        195                 200                 205             


Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln 
    210                 215                 220                 


Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser 
225                 230                 235                 240 


Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln 
                245                 250                 255     


Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp 
            260                 265                 270         


Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu 
        275                 280                 285             


Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg 
    290                 295                 300                 


Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu 
305                 310                 315                 320 


Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr 
                325                 330                 335     


Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val 
            340                 345                 350         


Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser 
        355                 360                 365             


Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser 
    370                 375                 380                 


Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr 
385                 390                 395                 400 


Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly 
                405                 410                 415     


Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly 
            420                 425                 430         


Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro 
        435                 440                 445             


Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro 
    450                 455                 460                 


Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr 
465                 470                 475                 480 


Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val 
                485                 490                 495     


Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro 
            500                 505                 510         


Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe 
        515                 520                 525             


Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe 
    530                 535                 540                 


Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala 
545                 550                 555                 560 


Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser 
                565                 570                 575     


Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln 
            580                 585                 590         


Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala 
        595                 600                 605             


Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly 
    610                 615                 620                 


Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His 
625                 630                 635                 640 


Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys 
                645                 650                 655     


Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro Gly Ser Ala Ser Ser Val 
            660                 665                 670         


Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn 
        675                 680                 685             


Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr 
    690                 695                 700                 


Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser 
705                 710                 715                 720 


Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn 
                725                 730                 735     


Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu 
            740                 745                 750         


Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala 
        755                 760                 765             


Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly 
    770                 775                 780                 


Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg 
785                 790                 795                 800 


Ser Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala 
                805                 810                 815     


Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg 
            820                 825                 830         


Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro 
        835                 840                 845             


Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala 
    850                 855                 860                 


Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln 
865                 870                 875                 880 


Ile Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val 
                885                 890                 895     


Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe 
            900                 905                 910         


Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser 
        915                 920                 925             


Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu 
    930                 935                 940                 


Asn Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser 
945                 950                 955                 960 


Val Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val 
                965                 970                 975     


Gln Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser Leu Gln Thr Tyr 
            980                 985                 990         


Val Thr Gln Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
        995                 1000                 1005             


Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1010                 1015                 1020             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1025                 1030                 1035             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1040                 1045                 1050             


Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1055                 1060                 1065             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1070                 1075                 1080             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1085                 1090                 1095             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1100                 1105                 1110             


Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro 
    1115                 1120                 1125             


Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Tyr  Phe Lys Asn 
    1130                 1135                 1140             


His Thr  Ser Pro Asp Val Asp  Leu Gly Asp Ile Ser  Gly Ile Asn 
    1145                 1150                 1155             


Ala Ser  Val Val Asn Ile Gln  Lys Glu Ile Asp Arg  Leu Asn Glu 
    1160                 1165                 1170             


Val Ala  Lys Asn Leu Asn Glu  Ser Leu Ile Asp Leu  Gln Glu Leu 
    1175                 1180                 1185             


Gly Lys  Tyr Glu Gln Gly Ser  Gly Tyr Ile Pro Glu  Ala Pro Arg 
    1190                 1195                 1200             


Asp Gly  Gln Ala Tyr Val Arg  Lys Asp Gly Glu Trp  Val Leu Leu 
    1205                 1210                 1215             


Ser Thr  Phe Leu Gly Leu Glu  Val Leu Phe Gln Gly  Pro Ser Ala 
    1220                 1225                 1230             


Trp Ser  His Pro Gln Phe Glu  Lys Gly Gly Gly Ser  Gly Gly Gly 
    1235                 1240                 1245             


Ser Gly  Gly Ser Ala Trp Ser  His Pro Gln Phe Glu  Lys Gly Ser 
    1250                 1255                 1260             


His His  His His His His His  His 
    1265                 1270     


<210> 133
<211> 1271
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 133
Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser 
1               5                   10                  15      


Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val 
            20                  25                  30          


Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr 
        35                  40                  45              


Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe 
    50                  55                  60                  


Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr 
65                  70                  75                  80  


Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp 
                85                  90                  95      


Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val 
            100                 105                 110         


Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val 
        115                 120                 125             


Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val 
    130                 135                 140                 


Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe 
145                 150                 155                 160 


Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu 
                165                 170                 175     


Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His 
            180                 185                 190         


Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu 
        195                 200                 205             


Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln 
    210                 215                 220                 


Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser 
225                 230                 235                 240 


Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln 
                245                 250                 255     


Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp 
            260                 265                 270         


Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu 
        275                 280                 285             


Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg 
    290                 295                 300                 


Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu 
305                 310                 315                 320 


Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr 
                325                 330                 335     


Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val 
            340                 345                 350         


Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser 
        355                 360                 365             


Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser 
    370                 375                 380                 


Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr 
385                 390                 395                 400 


Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly 
                405                 410                 415     


Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly 
            420                 425                 430         


Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro 
        435                 440                 445             


Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro 
    450                 455                 460                 


Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr 
465                 470                 475                 480 


Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val 
                485                 490                 495     


Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro 
            500                 505                 510         


Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe 
        515                 520                 525             


Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe 
    530                 535                 540                 


Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala 
545                 550                 555                 560 


Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser 
                565                 570                 575     


Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln 
            580                 585                 590         


Val Ala Val Leu Tyr Gln Gly Val Asn Cys Thr Glu Val Pro Val Ala 
        595                 600                 605             


Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly 
    610                 615                 620                 


Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His 
625                 630                 635                 640 


Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys 
                645                 650                 655     


Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro Gly Ser Ala Ser Ser Val 
            660                 665                 670         


Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn 
        675                 680                 685             


Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr 
    690                 695                 700                 


Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser 
705                 710                 715                 720 


Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn 
                725                 730                 735     


Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu 
            740                 745                 750         


Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala 
        755                 760                 765             


Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly 
    770                 775                 780                 


Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg 
785                 790                 795                 800 


Ser Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala 
                805                 810                 815     


Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg 
            820                 825                 830         


Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro 
        835                 840                 845             


Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala 
    850                 855                 860                 


Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln 
865                 870                 875                 880 


Ile Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val 
                885                 890                 895     


Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe 
            900                 905                 910         


Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser 
        915                 920                 925             


Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu 
    930                 935                 940                 


Asn Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser 
945                 950                 955                 960 


Val Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val 
                965                 970                 975     


Gln Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser Leu Gln Thr Tyr 
            980                 985                 990         


Val Thr Gln Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
        995                 1000                 1005             


Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1010                 1015                 1020             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1025                 1030                 1035             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1040                 1045                 1050             


Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1055                 1060                 1065             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1070                 1075                 1080             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1085                 1090                 1095             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1100                 1105                 1110             


Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro 
    1115                 1120                 1125             


Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Tyr  Phe Lys Asn 
    1130                 1135                 1140             


His Thr  Ser Pro Asp Val Asp  Leu Gly Asp Ile Ser  Gly Ile Asn 
    1145                 1150                 1155             


Ala Ser  Val Val Asn Ile Gln  Lys Glu Ile Asp Arg  Leu Asn Glu 
    1160                 1165                 1170             


Val Ala  Lys Asn Leu Asn Glu  Ser Leu Ile Asp Leu  Gln Glu Leu 
    1175                 1180                 1185             


Gly Lys  Tyr Glu Gln Gly Ser  Gly Tyr Ile Pro Glu  Ala Pro Arg 
    1190                 1195                 1200             


Asp Gly  Gln Ala Tyr Val Arg  Lys Asp Gly Glu Trp  Val Leu Leu 
    1205                 1210                 1215             


Ser Thr  Phe Leu Gly Leu Glu  Val Leu Phe Gln Gly  Pro Ser Ala 
    1220                 1225                 1230             


Trp Ser  His Pro Gln Phe Glu  Lys Gly Gly Gly Ser  Gly Gly Gly 
    1235                 1240                 1245             


Ser Gly  Gly Ser Ala Trp Ser  His Pro Gln Phe Glu  Lys Gly Ser 
    1250                 1255                 1260             


His His  His His His His His  His 
    1265                 1270     


<210> 134
<211> 1271
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 134
Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser 
1               5                   10                  15      


Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val 
            20                  25                  30          


Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr 
        35                  40                  45              


Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe 
    50                  55                  60                  


Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr 
65                  70                  75                  80  


Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp 
                85                  90                  95      


Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val 
            100                 105                 110         


Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val 
        115                 120                 125             


Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val 
    130                 135                 140                 


Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe 
145                 150                 155                 160 


Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu 
                165                 170                 175     


Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His 
            180                 185                 190         


Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu 
        195                 200                 205             


Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln 
    210                 215                 220                 


Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser 
225                 230                 235                 240 


Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln 
                245                 250                 255     


Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp 
            260                 265                 270         


Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu 
        275                 280                 285             


Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg 
    290                 295                 300                 


Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu 
305                 310                 315                 320 


Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr 
                325                 330                 335     


Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val 
            340                 345                 350         


Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser 
        355                 360                 365             


Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser 
    370                 375                 380                 


Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr 
385                 390                 395                 400 


Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly 
                405                 410                 415     


Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly 
            420                 425                 430         


Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro 
        435                 440                 445             


Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro 
    450                 455                 460                 


Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr 
465                 470                 475                 480 


Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val 
                485                 490                 495     


Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro 
            500                 505                 510         


Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe 
        515                 520                 525             


Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe 
    530                 535                 540                 


Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala 
545                 550                 555                 560 


Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser 
                565                 570                 575     


Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln 
            580                 585                 590         


Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala 
        595                 600                 605             


Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly 
    610                 615                 620                 


Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His 
625                 630                 635                 640 


Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys 
                645                 650                 655     


Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val 
            660                 665                 670         


Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn 
        675                 680                 685             


Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr 
    690                 695                 700                 


Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser 
705                 710                 715                 720 


Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn 
                725                 730                 735     


Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu 
            740                 745                 750         


Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala 
        755                 760                 765             


Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly 
    770                 775                 780                 


Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg 
785                 790                 795                 800 


Ser Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala 
                805                 810                 815     


Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg 
            820                 825                 830         


Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro 
        835                 840                 845             


Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala 
    850                 855                 860                 


Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln 
865                 870                 875                 880 


Ile Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val 
                885                 890                 895     


Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe 
            900                 905                 910         


Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser 
        915                 920                 925             


Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu 
    930                 935                 940                 


Asn Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser 
945                 950                 955                 960 


Val Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val 
                965                 970                 975     


Gln Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser Leu Gln Thr Tyr 
            980                 985                 990         


Val Thr Gln Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
        995                 1000                 1005             


Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1010                 1015                 1020             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1025                 1030                 1035             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1040                 1045                 1050             


Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1055                 1060                 1065             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1070                 1075                 1080             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1085                 1090                 1095             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1100                 1105                 1110             


Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro 
    1115                 1120                 1125             


Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Tyr  Phe Lys Asn 
    1130                 1135                 1140             


His Thr  Ser Pro Asp Val Asp  Leu Gly Asp Ile Ser  Gly Ile Asn 
    1145                 1150                 1155             


Ala Ser  Val Val Asn Ile Gln  Lys Glu Ile Asp Arg  Leu Asn Glu 
    1160                 1165                 1170             


Val Ala  Lys Asn Leu Asn Glu  Ser Leu Ile Asp Leu  Gln Glu Leu 
    1175                 1180                 1185             


Gly Lys  Tyr Glu Gln Gly Ser  Gly Tyr Ile Pro Glu  Ala Pro Arg 
    1190                 1195                 1200             


Asp Gly  Gln Ala Tyr Val Arg  Lys Asp Gly Glu Trp  Val Leu Leu 
    1205                 1210                 1215             


Ser Thr  Phe Leu Gly Leu Glu  Val Leu Phe Gln Gly  Pro Ser Ala 
    1220                 1225                 1230             


Trp Ser  His Pro Gln Phe Glu  Lys Gly Gly Gly Ser  Gly Gly Gly 
    1235                 1240                 1245             


Ser Gly  Gly Ser Ala Trp Ser  His Pro Gln Phe Glu  Lys Gly Ser 
    1250                 1255                 1260             


His His  His His His His His  His 
    1265                 1270     


<210> 135
<211> 1271
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 135
Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser 
1               5                   10                  15      


Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val 
            20                  25                  30          


Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr 
        35                  40                  45              


Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe 
    50                  55                  60                  


Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr 
65                  70                  75                  80  


Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp 
                85                  90                  95      


Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val 
            100                 105                 110         


Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val 
        115                 120                 125             


Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val 
    130                 135                 140                 


Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe 
145                 150                 155                 160 


Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu 
                165                 170                 175     


Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His 
            180                 185                 190         


Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu 
        195                 200                 205             


Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln 
    210                 215                 220                 


Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser 
225                 230                 235                 240 


Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln 
                245                 250                 255     


Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp 
            260                 265                 270         


Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu 
        275                 280                 285             


Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg 
    290                 295                 300                 


Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu 
305                 310                 315                 320 


Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr 
                325                 330                 335     


Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val 
            340                 345                 350         


Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser 
        355                 360                 365             


Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser 
    370                 375                 380                 


Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr 
385                 390                 395                 400 


Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly 
                405                 410                 415     


Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly 
            420                 425                 430         


Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro 
        435                 440                 445             


Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro 
    450                 455                 460                 


Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr 
465                 470                 475                 480 


Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val 
                485                 490                 495     


Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro 
            500                 505                 510         


Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe 
        515                 520                 525             


Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe 
    530                 535                 540                 


Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala 
545                 550                 555                 560 


Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser 
                565                 570                 575     


Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln 
            580                 585                 590         


Val Ala Val Leu Tyr Gln Gly Val Asn Cys Thr Glu Val Pro Val Ala 
        595                 600                 605             


Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly 
    610                 615                 620                 


Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His 
625                 630                 635                 640 


Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys 
                645                 650                 655     


Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val 
            660                 665                 670         


Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn 
        675                 680                 685             


Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr 
    690                 695                 700                 


Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser 
705                 710                 715                 720 


Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn 
                725                 730                 735     


Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu 
            740                 745                 750         


Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala 
        755                 760                 765             


Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly 
    770                 775                 780                 


Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg 
785                 790                 795                 800 


Ser Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala 
                805                 810                 815     


Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg 
            820                 825                 830         


Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro 
        835                 840                 845             


Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala 
    850                 855                 860                 


Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln 
865                 870                 875                 880 


Ile Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val 
                885                 890                 895     


Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe 
            900                 905                 910         


Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser 
        915                 920                 925             


Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu 
    930                 935                 940                 


Asn Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser 
945                 950                 955                 960 


Val Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val 
                965                 970                 975     


Gln Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser Leu Gln Thr Tyr 
            980                 985                 990         


Val Thr Gln Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
        995                 1000                 1005             


Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1010                 1015                 1020             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1025                 1030                 1035             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1040                 1045                 1050             


Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1055                 1060                 1065             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1070                 1075                 1080             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1085                 1090                 1095             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1100                 1105                 1110             


Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro 
    1115                 1120                 1125             


Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Tyr  Phe Lys Asn 
    1130                 1135                 1140             


His Thr  Ser Pro Asp Val Asp  Leu Gly Asp Ile Ser  Gly Ile Asn 
    1145                 1150                 1155             


Ala Ser  Val Val Asn Ile Gln  Lys Glu Ile Asp Arg  Leu Asn Glu 
    1160                 1165                 1170             


Val Ala  Lys Asn Leu Asn Glu  Ser Leu Ile Asp Leu  Gln Glu Leu 
    1175                 1180                 1185             


Gly Lys  Tyr Glu Gln Gly Ser  Gly Tyr Ile Pro Glu  Ala Pro Arg 
    1190                 1195                 1200             


Asp Gly  Gln Ala Tyr Val Arg  Lys Asp Gly Glu Trp  Val Leu Leu 
    1205                 1210                 1215             


Ser Thr  Phe Leu Gly Leu Glu  Val Leu Phe Gln Gly  Pro Ser Ala 
    1220                 1225                 1230             


Trp Ser  His Pro Gln Phe Glu  Lys Gly Gly Gly Ser  Gly Gly Gly 
    1235                 1240                 1245             


Ser Gly  Gly Ser Ala Trp Ser  His Pro Gln Phe Glu  Lys Gly Ser 
    1250                 1255                 1260             


His His  His His His His His  His 
    1265                 1270     


<210> 136
<211> 694
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 136
His His His His His His His His Gly Pro Leu Glu Val Leu Phe Gln 
1               5                   10                  15      


Gly Pro Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala 
            20                  25                  30          


Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn 
        35                  40                  45              


Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr 
    50                  55                  60                  


Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe 
65                  70                  75                  80  


Thr Asn Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg 
                85                  90                  95      


Gln Ile Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys 
            100                 105                 110         


Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn 
        115                 120                 125             


Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Arg Arg Leu Phe 
    130                 135                 140                 


Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile 
145                 150                 155                 160 


Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys 
                165                 170                 175     


Tyr Phe Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly 
            180                 185                 190         


Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe Glu Asn Lys Ser Ala 
        195                 200                 205             


Pro Ala Thr Val Cys Gly Pro Gly Ser Gly Gly Ser Gly Ser Ser Gln 
    210                 215                 220                 


Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn 
225                 230                 235                 240 


Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser 
                245                 250                 255     


Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val 
            260                 265                 270         


Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg 
        275                 280                 285             


Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser 
    290                 295                 300                 


Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu 
305                 310                 315                 320 


Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val 
                325                 330                 335     


Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly 
            340                 345                 350         


Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg 
        355                 360                 365             


Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro 
    370                 375                 380                 


Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg 
385                 390                 395                 400 


Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys 
                405                 410                 415     


His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala 
            420                 425                 430         


Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe 
        435                 440                 445             


Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser 
    450                 455                 460                 


Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu 
465                 470                 475                 480 


Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr 
                485                 490                 495     


Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr 
            500                 505                 510         


Leu Gly Ser Gly Gly Gly Gly Glu Ser Gln Val Arg Gln Gln Phe Ser 
        515                 520                 525             


Lys Asp Ile Glu Lys Leu Leu Asn Glu Gln Val Asn Lys Glu Met Gln 
    530                 535                 540                 


Ser Ser Asn Leu Tyr Met Ser Met Ser Ser Trp Cys Tyr Thr His Ser 
545                 550                 555                 560 


Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp His Ala Ala Glu Glu Tyr 
                565                 570                 575     


Glu His Ala Lys Lys Leu Ile Ile Phe Leu Asn Glu Asn Asn Val Pro 
            580                 585                 590         


Val Gln Leu Thr Ser Ile Ser Ala Pro Glu His Lys Phe Glu Gly Leu 
        595                 600                 605             


Thr Gln Ile Phe Gln Lys Ala Tyr Glu His Glu Gln His Ile Ser Glu 
    610                 615                 620                 


Ser Ile Asn Asn Ile Val Asp His Ala Ile Lys Ser Lys Asp His Ala 
625                 630                 635                 640 


Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala Glu Gln His Glu Glu Glu 
                645                 650                 655     


Val Leu Phe Lys Asp Ile Leu Asp Lys Ile Glu Leu Ile Gly Asn Glu 
            660                 665                 670         


Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr Val Lys Gly Ile Ala Lys 
        675                 680                 685             


Ser Arg Lys Ser Gly Ser 
    690                 


<210> 137
<211> 694
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 137
His His His His His His His His Gly Pro Leu Glu Val Leu Phe Gln 
1               5                   10                  15      


Gly Pro Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala 
            20                  25                  30          


Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn 
        35                  40                  45              


Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr 
    50                  55                  60                  


Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe 
65                  70                  75                  80  


Thr Asn Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg 
                85                  90                  95      


Gln Ile Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys 
            100                 105                 110         


Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn 
        115                 120                 125             


Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe 
    130                 135                 140                 


Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile 
145                 150                 155                 160 


Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys 
                165                 170                 175     


Tyr Ala Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly 
            180                 185                 190         


Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe Glu Asn Lys Ser Ala 
        195                 200                 205             


Pro Ala Thr Val Cys Gly Pro Gly Ser Gly Gly Ser Gly Ser Ser Gln 
    210                 215                 220                 


Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn 
225                 230                 235                 240 


Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser 
                245                 250                 255     


Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val 
            260                 265                 270         


Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg 
        275                 280                 285             


Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser 
    290                 295                 300                 


Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu 
305                 310                 315                 320 


Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val 
                325                 330                 335     


Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly 
            340                 345                 350         


Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg 
        355                 360                 365             


Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro 
    370                 375                 380                 


Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg 
385                 390                 395                 400 


Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys 
                405                 410                 415     


His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala 
            420                 425                 430         


Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe 
        435                 440                 445             


Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser 
    450                 455                 460                 


Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu 
465                 470                 475                 480 


Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr 
                485                 490                 495     


Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr 
            500                 505                 510         


Leu Gly Ser Gly Gly Gly Gly Glu Ser Gln Val Arg Gln Gln Phe Ser 
        515                 520                 525             


Lys Asp Ile Glu Lys Leu Leu Asn Glu Gln Val Asn Lys Glu Met Gln 
    530                 535                 540                 


Ser Ser Asn Leu Tyr Met Ser Met Ser Ser Trp Cys Tyr Thr His Ser 
545                 550                 555                 560 


Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp His Ala Ala Glu Glu Tyr 
                565                 570                 575     


Glu His Ala Lys Lys Leu Ile Ile Phe Leu Asn Glu Asn Asn Val Pro 
            580                 585                 590         


Val Gln Leu Thr Ser Ile Ser Ala Pro Glu His Lys Phe Glu Gly Leu 
        595                 600                 605             


Thr Gln Ile Phe Gln Lys Ala Tyr Glu His Glu Gln His Ile Ser Glu 
    610                 615                 620                 


Ser Ile Asn Asn Ile Val Asp His Ala Ile Lys Ser Lys Asp His Ala 
625                 630                 635                 640 


Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala Glu Gln His Glu Glu Glu 
                645                 650                 655     


Val Leu Phe Lys Asp Ile Leu Asp Lys Ile Glu Leu Ile Gly Asn Glu 
            660                 665                 670         


Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr Val Lys Gly Ile Ala Lys 
        675                 680                 685             


Ser Arg Lys Ser Gly Ser 
    690                 


<210> 138
<211> 856
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 138
Ser Ser Gln Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala 
1               5                   10                  15      


Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe 
            20                  25                  30          


Arg Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe 
        35                  40                  45              


Ser Asn Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly 
    50                  55                  60                  


Thr Lys Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr 
65                  70                  75                  80  


Phe Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly 
                85                  90                  95      


Thr Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala 
            100                 105                 110         


Thr Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro 
        115                 120                 125             


Phe Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser 
    130                 135                 140                 


Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val 
145                 150                 155                 160 


Ser Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys 
                165                 170                 175     


Asn Leu Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile 
            180                 185                 190         


Tyr Ser Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly 
        195                 200                 205             


Phe Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile 
    210                 215                 220                 


Thr Arg Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro 
225                 230                 235                 240 


Gly Asp Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val 
                245                 250                 255     


Gly Tyr Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly 
            260                 265                 270         


Thr Ile Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr 
        275                 280                 285             


Lys Cys Thr Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr 
    290                 295                 300                 


Ser Asn Phe Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn 
305                 310                 315                 320 


Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe 
                325                 330                 335     


Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala 
            340                 345                 350         


Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys 
        355                 360                 365             


Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val 
    370                 375                 380                 


Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala 
385                 390                 395                 400 


Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp 
                405                 410                 415     


Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser 
            420                 425                 430         


Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser 
        435                 440                 445             


Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala 
    450                 455                 460                 


Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro 
465                 470                 475                 480 


Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro 
                485                 490                 495     


Tyr Arg Val Val Val Leu Ser Phe Glu Asn Lys Ser Ala Pro Ala Thr 
            500                 505                 510         


Val Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val 
        515                 520                 525             


Asn Phe Asn Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser 
    530                 535                 540                 


Asn Lys Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp 
545                 550                 555                 560 


Thr Thr Asp Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile 
                565                 570                 575     


Thr Pro Cys Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn 
            580                 585                 590         


Thr Ser Asn Gln Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu 
        595                 600                 605             


Val Pro Val Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val 
    610                 615                 620                 


Tyr Ser Thr Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile 
625                 630                 635                 640 


Gly Ala Glu His Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly 
                645                 650                 655     


Ala Gly Ile Cys Ala Ser Tyr Gln Thr Gly Gly Ser Gln Ser Ile Ile 
            660                 665                 670         


Ala Tyr Thr Gly Ser Gly Gly Gly Gly Glu Ser Gln Val Arg Gln Gln 
        675                 680                 685             


Phe Ser Lys Asp Ile Glu Lys Leu Leu Asn Glu Gln Val Asn Lys Glu 
    690                 695                 700                 


Met Gln Ser Ser Asn Leu Tyr Met Ser Met Ser Ser Trp Cys Tyr Thr 
705                 710                 715                 720 


His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp His Ala Ala Glu 
                725                 730                 735     


Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe Leu Asn Glu Asn Asn 
            740                 745                 750         


Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro Glu His Lys Phe Glu 
        755                 760                 765             


Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu His Glu Gln His Ile 
    770                 775                 780                 


Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala Ile Lys Ser Lys Asp 
785                 790                 795                 800 


His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala Glu Gln His Glu 
                805                 810                 815     


Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys Ile Glu Leu Ile Gly 
            820                 825                 830         


Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr Val Lys Gly Ile 
        835                 840                 845             


Ala Lys Ser Arg Lys Ser Gly Ser 
    850                 855     


<210> 139
<211> 856
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 139
Ser Ser Gln Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala 
1               5                   10                  15      


Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe 
            20                  25                  30          


Arg Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe 
        35                  40                  45              


Ser Asn Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly 
    50                  55                  60                  


Thr Lys Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr 
65                  70                  75                  80  


Phe Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly 
                85                  90                  95      


Thr Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala 
            100                 105                 110         


Thr Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro 
        115                 120                 125             


Phe Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser 
    130                 135                 140                 


Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val 
145                 150                 155                 160 


Ser Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys 
                165                 170                 175     


Asn Leu Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile 
            180                 185                 190         


Tyr Ser Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly 
        195                 200                 205             


Phe Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile 
    210                 215                 220                 


Thr Arg Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro 
225                 230                 235                 240 


Gly Asp Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val 
                245                 250                 255     


Gly Tyr Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly 
            260                 265                 270         


Thr Ile Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr 
        275                 280                 285             


Lys Cys Thr Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr 
    290                 295                 300                 


Ser Asn Phe Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn 
305                 310                 315                 320 


Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe 
                325                 330                 335     


Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala 
            340                 345                 350         


Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys 
        355                 360                 365             


Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val 
    370                 375                 380                 


Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala 
385                 390                 395                 400 


Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp 
                405                 410                 415     


Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser 
            420                 425                 430         


Lys Val Gly Gly Asn Lys Asn Tyr Leu Tyr Arg Arg Phe Arg Lys Ser 
        435                 440                 445             


Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala 
    450                 455                 460                 


Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Arg Pro 
465                 470                 475                 480 


Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro 
                485                 490                 495     


Tyr Arg Val Val Val Leu Ser Phe Glu Asn Lys Ser Ala Pro Ala Thr 
            500                 505                 510         


Val Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val 
        515                 520                 525             


Asn Phe Asn Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser 
    530                 535                 540                 


Asn Lys Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp 
545                 550                 555                 560 


Thr Thr Asp Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile 
                565                 570                 575     


Thr Pro Cys Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn 
            580                 585                 590         


Thr Ser Asn Gln Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu 
        595                 600                 605             


Val Pro Val Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val 
    610                 615                 620                 


Tyr Ser Thr Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile 
625                 630                 635                 640 


Gly Ala Glu His Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly 
                645                 650                 655     


Ala Gly Ile Cys Ala Ser Tyr Gln Thr Gly Gly Ser Gln Ser Ile Ile 
            660                 665                 670         


Ala Tyr Thr Gly Ser Gly Gly Gly Gly Glu Ser Gln Val Arg Gln Gln 
        675                 680                 685             


Phe Ser Lys Asp Ile Glu Lys Leu Leu Asn Glu Gln Val Asn Lys Glu 
    690                 695                 700                 


Met Gln Ser Ser Asn Leu Tyr Met Ser Met Ser Ser Trp Cys Tyr Thr 
705                 710                 715                 720 


His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp His Ala Ala Glu 
                725                 730                 735     


Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe Leu Asn Glu Asn Asn 
            740                 745                 750         


Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro Glu His Lys Phe Glu 
        755                 760                 765             


Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu His Glu Gln His Ile 
    770                 775                 780                 


Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala Ile Lys Ser Lys Asp 
785                 790                 795                 800 


His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala Glu Gln His Glu 
                805                 810                 815     


Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys Ile Glu Leu Ile Gly 
            820                 825                 830         


Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr Val Lys Gly Ile 
        835                 840                 845             


Ala Lys Ser Arg Lys Ser Gly Ser 
    850                 855     


<210> 140
<211> 856
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 140
Ser Ser Gln Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala 
1               5                   10                  15      


Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe 
            20                  25                  30          


Arg Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe 
        35                  40                  45              


Ser Asn Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly 
    50                  55                  60                  


Thr Lys Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr 
65                  70                  75                  80  


Phe Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly 
                85                  90                  95      


Thr Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala 
            100                 105                 110         


Thr Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro 
        115                 120                 125             


Phe Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser 
    130                 135                 140                 


Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val 
145                 150                 155                 160 


Ser Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys 
                165                 170                 175     


Asn Leu Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile 
            180                 185                 190         


Tyr Ser Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly 
        195                 200                 205             


Phe Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile 
    210                 215                 220                 


Thr Arg Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro 
225                 230                 235                 240 


Gly Asp Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val 
                245                 250                 255     


Gly Tyr Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly 
            260                 265                 270         


Thr Ile Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr 
        275                 280                 285             


Lys Cys Thr Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr 
    290                 295                 300                 


Ser Asn Phe Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn 
305                 310                 315                 320 


Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe 
                325                 330                 335     


Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala 
            340                 345                 350         


Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys 
        355                 360                 365             


Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val 
    370                 375                 380                 


Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala 
385                 390                 395                 400 


Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp 
                405                 410                 415     


Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser 
            420                 425                 430         


Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser 
        435                 440                 445             


Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala 
    450                 455                 460                 


Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Ala Pro 
465                 470                 475                 480 


Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro 
                485                 490                 495     


Tyr Arg Val Val Val Leu Ser Phe Glu Asn Lys Ser Ala Pro Ala Thr 
            500                 505                 510         


Val Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val 
        515                 520                 525             


Asn Phe Asn Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser 
    530                 535                 540                 


Asn Lys Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp 
545                 550                 555                 560 


Thr Thr Asp Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile 
                565                 570                 575     


Thr Pro Cys Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn 
            580                 585                 590         


Thr Ser Asn Gln Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu 
        595                 600                 605             


Val Pro Val Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val 
    610                 615                 620                 


Tyr Ser Thr Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile 
625                 630                 635                 640 


Gly Ala Glu His Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly 
                645                 650                 655     


Ala Gly Ile Cys Ala Ser Tyr Gln Thr Gly Gly Ser Gln Ser Ile Ile 
            660                 665                 670         


Ala Tyr Thr Gly Ser Gly Gly Gly Gly Glu Ser Gln Val Arg Gln Gln 
        675                 680                 685             


Phe Ser Lys Asp Ile Glu Lys Leu Leu Asn Glu Gln Val Asn Lys Glu 
    690                 695                 700                 


Met Gln Ser Ser Asn Leu Tyr Met Ser Met Ser Ser Trp Cys Tyr Thr 
705                 710                 715                 720 


His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp His Ala Ala Glu 
                725                 730                 735     


Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe Leu Asn Glu Asn Asn 
            740                 745                 750         


Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro Glu His Lys Phe Glu 
        755                 760                 765             


Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu His Glu Gln His Ile 
    770                 775                 780                 


Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala Ile Lys Ser Lys Asp 
785                 790                 795                 800 


His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala Glu Gln His Glu 
                805                 810                 815     


Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys Ile Glu Leu Ile Gly 
            820                 825                 830         


Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr Val Lys Gly Ile 
        835                 840                 845             


Ala Lys Ser Arg Lys Ser Gly Ser 
    850                 855     


<210> 141
<211> 694
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 141
His His His His His His His His Gly Pro Leu Glu Val Leu Phe Gln 
1               5                   10                  15      


Gly Pro Ser Ser Gln Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro 
            20                  25                  30          


Pro Ala Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys 
        35                  40                  45              


Val Phe Arg Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro 
    50                  55                  60                  


Phe Phe Ser Asn Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr 
65                  70                  75                  80  


Asn Gly Thr Lys Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly 
                85                  90                  95      


Val Tyr Phe Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile 
            100                 105                 110         


Phe Gly Thr Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn 
        115                 120                 125             


Asn Ala Thr Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn 
    130                 135                 140                 


Asp Pro Phe Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met 
145                 150                 155                 160 


Glu Ser Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu 
                165                 170                 175     


Tyr Val Ser Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn 
            180                 185                 190         


Phe Lys Asn Leu Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe 
        195                 200                 205             


Lys Ile Tyr Ser Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro 
    210                 215                 220                 


Gln Gly Phe Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile 
225                 230                 235                 240 


Asn Ile Thr Arg Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu 
                245                 250                 255     


Thr Pro Gly Asp Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr 
            260                 265                 270         


Tyr Val Gly Tyr Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu 
        275                 280                 285             


Asn Gly Thr Ile Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser 
    290                 295                 300                 


Glu Thr Lys Cys Thr Leu Gly Ser Gly Gly Ser Gly Asn Ile Thr Asn 
305                 310                 315                 320 


Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val 
                325                 330                 335     


Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser 
            340                 345                 350         


Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val 
        355                 360                 365             


Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp 
    370                 375                 380                 


Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln 
385                 390                 395                 400 


Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr 
                405                 410                 415     


Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly 
            420                 425                 430         


Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys 
        435                 440                 445             


Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr 
    450                 455                 460                 


Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Ala Pro Leu Gln Ser 
465                 470                 475                 480 


Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val 
                485                 490                 495     


Val Val Leu Ser Phe Glu Asn Lys Ser Ala Pro Ala Thr Val Cys Gly 
            500                 505                 510         


Pro Gly Ser Gly Gly Gly Gly Glu Ser Gln Val Arg Gln Gln Phe Ser 
        515                 520                 525             


Lys Asp Ile Glu Lys Leu Leu Asn Glu Gln Val Asn Lys Glu Met Gln 
    530                 535                 540                 


Ser Ser Asn Leu Tyr Met Ser Met Ser Ser Trp Cys Tyr Thr His Ser 
545                 550                 555                 560 


Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp His Ala Ala Glu Glu Tyr 
                565                 570                 575     


Glu His Ala Lys Lys Leu Ile Ile Phe Leu Asn Glu Asn Asn Val Pro 
            580                 585                 590         


Val Gln Leu Thr Ser Ile Ser Ala Pro Glu His Lys Phe Glu Gly Leu 
        595                 600                 605             


Thr Gln Ile Phe Gln Lys Ala Tyr Glu His Glu Gln His Ile Ser Glu 
    610                 615                 620                 


Ser Ile Asn Asn Ile Val Asp His Ala Ile Lys Ser Lys Asp His Ala 
625                 630                 635                 640 


Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala Glu Gln His Glu Glu Glu 
                645                 650                 655     


Val Leu Phe Lys Asp Ile Leu Asp Lys Ile Glu Leu Ile Gly Asn Glu 
            660                 665                 670         


Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr Val Lys Gly Ile Ala Lys 
        675                 680                 685             


Ser Arg Lys Ser Gly Ser 
    690                 


<210> 142
<211> 694
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 142
His His His His His His His His Gly Pro Leu Glu Val Leu Phe Gln 
1               5                   10                  15      


Gly Pro Ser Ser Gln Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro 
            20                  25                  30          


Pro Ala Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys 
        35                  40                  45              


Val Phe Arg Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro 
    50                  55                  60                  


Phe Phe Ser Asn Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr 
65                  70                  75                  80  


Asn Gly Thr Lys Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly 
                85                  90                  95      


Val Tyr Phe Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile 
            100                 105                 110         


Phe Gly Thr Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn 
        115                 120                 125             


Asn Ala Thr Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn 
    130                 135                 140                 


Asp Pro Phe Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met 
145                 150                 155                 160 


Glu Ser Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu 
                165                 170                 175     


Tyr Val Ser Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn 
            180                 185                 190         


Phe Lys Asn Leu Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe 
        195                 200                 205             


Lys Ile Tyr Ser Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro 
    210                 215                 220                 


Gln Gly Phe Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile 
225                 230                 235                 240 


Asn Ile Thr Arg Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu 
                245                 250                 255     


Thr Pro Gly Asp Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr 
            260                 265                 270         


Tyr Val Gly Tyr Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu 
        275                 280                 285             


Asn Gly Thr Ile Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser 
    290                 295                 300                 


Glu Thr Lys Cys Thr Leu Gly Ser Gly Gly Ser Gly Asn Ile Thr Asn 
305                 310                 315                 320 


Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val 
                325                 330                 335     


Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser 
            340                 345                 350         


Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val 
        355                 360                 365             


Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp 
    370                 375                 380                 


Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln 
385                 390                 395                 400 


Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr 
                405                 410                 415     


Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly 
            420                 425                 430         


Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys 
        435                 440                 445             


Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr 
    450                 455                 460                 


Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser 
465                 470                 475                 480 


Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val 
                485                 490                 495     


Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly 
            500                 505                 510         


Pro Gly Ser Gly Gly Gly Gly Glu Ser Gln Val Arg Gln Gln Phe Ser 
        515                 520                 525             


Lys Asp Ile Glu Lys Leu Leu Asn Glu Gln Val Asn Lys Glu Met Gln 
    530                 535                 540                 


Ser Ser Asn Leu Tyr Met Ser Met Ser Ser Trp Cys Tyr Thr His Ser 
545                 550                 555                 560 


Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp His Ala Ala Glu Glu Tyr 
                565                 570                 575     


Glu His Ala Lys Lys Leu Ile Ile Phe Leu Asn Glu Asn Asn Val Pro 
            580                 585                 590         


Val Gln Leu Thr Ser Ile Ser Ala Pro Glu His Lys Phe Glu Gly Leu 
        595                 600                 605             


Thr Gln Ile Phe Gln Lys Ala Tyr Glu His Glu Gln His Ile Ser Glu 
    610                 615                 620                 


Ser Ile Asn Asn Ile Val Asp His Ala Ile Lys Ser Lys Asp His Ala 
625                 630                 635                 640 


Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala Glu Gln His Glu Glu Glu 
                645                 650                 655     


Val Leu Phe Lys Asp Ile Leu Asp Lys Ile Glu Leu Ile Gly Asn Glu 
            660                 665                 670         


Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr Val Lys Gly Ile Ala Lys 
        675                 680                 685             


Ser Arg Lys Ser Gly Ser 
    690                 


<210> 143
<211> 856
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 143
Ser Ser Gln Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala 
1               5                   10                  15      


Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe 
            20                  25                  30          


Arg Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe 
        35                  40                  45              


Ser Asn Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly 
    50                  55                  60                  


Thr Lys Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr 
65                  70                  75                  80  


Phe Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly 
                85                  90                  95      


Thr Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala 
            100                 105                 110         


Thr Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro 
        115                 120                 125             


Phe Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser 
    130                 135                 140                 


Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val 
145                 150                 155                 160 


Ser Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys 
                165                 170                 175     


Asn Leu Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile 
            180                 185                 190         


Tyr Ser Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly 
        195                 200                 205             


Phe Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile 
    210                 215                 220                 


Thr Arg Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro 
225                 230                 235                 240 


Gly Asp Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val 
                245                 250                 255     


Gly Tyr Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly 
            260                 265                 270         


Thr Ile Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr 
        275                 280                 285             


Lys Cys Thr Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr 
    290                 295                 300                 


Ser Asn Phe Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn 
305                 310                 315                 320 


Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe 
                325                 330                 335     


Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala 
            340                 345                 350         


Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys 
        355                 360                 365             


Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val 
    370                 375                 380                 


Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala 
385                 390                 395                 400 


Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp 
                405                 410                 415     


Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser 
            420                 425                 430         


Lys Val Gly Gly Asn Lys Asn Tyr Leu Tyr Arg Arg Phe Arg Lys Ser 
        435                 440                 445             


Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala 
    450                 455                 460                 


Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Arg Pro 
465                 470                 475                 480 


Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro 
                485                 490                 495     


Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr 
            500                 505                 510         


Val Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val 
        515                 520                 525             


Asn Phe Asn Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser 
    530                 535                 540                 


Asn Lys Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp 
545                 550                 555                 560 


Thr Thr Asp Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile 
                565                 570                 575     


Thr Pro Cys Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn 
            580                 585                 590         


Thr Ser Asn Gln Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu 
        595                 600                 605             


Val Pro Val Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val 
    610                 615                 620                 


Tyr Ser Thr Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile 
625                 630                 635                 640 


Gly Ala Glu His Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly 
                645                 650                 655     


Ala Gly Ile Cys Ala Ser Tyr Gln Thr Gly Gly Ser Gln Ser Ile Ile 
            660                 665                 670         


Ala Tyr Thr Gly Ser Gly Gly Gly Gly Glu Ser Gln Val Arg Gln Gln 
        675                 680                 685             


Phe Ser Lys Asp Ile Glu Lys Leu Leu Asn Glu Gln Val Asn Lys Glu 
    690                 695                 700                 


Met Gln Ser Ser Asn Leu Tyr Met Ser Met Ser Ser Trp Cys Tyr Thr 
705                 710                 715                 720 


His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp His Ala Ala Glu 
                725                 730                 735     


Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe Leu Asn Glu Asn Asn 
            740                 745                 750         


Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro Glu His Lys Phe Glu 
        755                 760                 765             


Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu His Glu Gln His Ile 
    770                 775                 780                 


Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala Ile Lys Ser Lys Asp 
785                 790                 795                 800 


His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala Glu Gln His Glu 
                805                 810                 815     


Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys Ile Glu Leu Ile Gly 
            820                 825                 830         


Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr Val Lys Gly Ile 
        835                 840                 845             


Ala Lys Ser Arg Lys Ser Gly Ser 
    850                 855     


<210> 144
<211> 1318
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 144
Ser Ser Gln Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala 
1               5                   10                  15      


Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe 
            20                  25                  30          


Arg Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe 
        35                  40                  45              


Ser Asn Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly 
    50                  55                  60                  


Thr Lys Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr 
65                  70                  75                  80  


Phe Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly 
                85                  90                  95      


Thr Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala 
            100                 105                 110         


Thr Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro 
        115                 120                 125             


Phe Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser 
    130                 135                 140                 


Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val 
145                 150                 155                 160 


Ser Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys 
                165                 170                 175     


Asn Leu Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile 
            180                 185                 190         


Tyr Ser Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly 
        195                 200                 205             


Phe Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile 
    210                 215                 220                 


Thr Arg Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro 
225                 230                 235                 240 


Gly Asp Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val 
                245                 250                 255     


Gly Tyr Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly 
            260                 265                 270         


Thr Ile Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr 
        275                 280                 285             


Lys Cys Thr Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr 
    290                 295                 300                 


Ser Asn Phe Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn 
305                 310                 315                 320 


Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe 
                325                 330                 335     


Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala 
            340                 345                 350         


Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys 
        355                 360                 365             


Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val 
    370                 375                 380                 


Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala 
385                 390                 395                 400 


Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp 
                405                 410                 415     


Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser 
            420                 425                 430         


Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser 
        435                 440                 445             


Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala 
    450                 455                 460                 


Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro 
465                 470                 475                 480 


Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro 
                485                 490                 495     


Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr 
            500                 505                 510         


Val Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val 
        515                 520                 525             


Asn Phe Asn Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser 
    530                 535                 540                 


Asn Lys Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp 
545                 550                 555                 560 


Thr Thr Asp Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile 
                565                 570                 575     


Thr Pro Cys Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn 
            580                 585                 590         


Thr Ser Asn Gln Val Ala Val Leu Tyr Gln Gly Val Asn Cys Thr Glu 
        595                 600                 605             


Val Pro Val Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val 
    610                 615                 620                 


Tyr Ser Thr Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile 
625                 630                 635                 640 


Gly Ala Glu His Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly 
                645                 650                 655     


Ala Gly Ile Cys Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro Gly Ser 
            660                 665                 670         


Ala Ser Ser Val Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu 
        675                 680                 685             


Gly Ala Glu Asn Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro 
    690                 695                 700                 


Thr Asn Phe Thr Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met 
705                 710                 715                 720 


Thr Lys Thr Ser Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr 
                725                 730                 735     


Glu Cys Ser Asn Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu 
            740                 745                 750         


Asn Arg Ala Leu Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln 
        755                 760                 765             


Glu Val Phe Ala Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys 
    770                 775                 780                 


Asp Phe Gly Gly Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys 
785                 790                 795                 800 


Pro Ser Lys Arg Ser Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr 
                805                 810                 815     


Leu Ala Asp Ala Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp 
            820                 825                 830         


Ile Ala Ala Arg Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr 
        835                 840                 845             


Val Leu Pro Pro Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser 
    850                 855                 860                 


Ala Leu Leu Ala Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly 
865                 870                 875                 880 


Ala Ala Leu Gln Ile Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn 
                885                 890                 895     


Gly Ile Gly Val Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile 
            900                 905                 910         


Ala Asn Gln Phe Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser 
        915                 920                 925             


Ser Thr Ala Ser Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn 
    930                 935                 940                 


Ala Gln Ala Leu Asn Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly 
945                 950                 955                 960 


Ala Ile Ser Ser Val Leu Asn Asp Ile Leu Ser Arg Leu Asp Pro Pro 
                965                 970                 975     


Glu Ala Glu Val Gln Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser 
            980                 985                 990         


Leu Gln Thr Tyr Val Thr Gln Gln  Leu Ile Arg Ala Ala  Glu Ile Arg 
        995                 1000                 1005             


Ala Ser  Ala Asn Leu Ala Ala  Thr Lys Met Ser Glu  Cys Val Leu 
    1010                 1015                 1020             


Gly Gln  Ser Lys Arg Val Asp  Phe Cys Gly Lys Gly  Tyr His Leu 
    1025                 1030                 1035             


Met Ser  Phe Pro Gln Ser Ala  Pro His Gly Val Val  Phe Leu His 
    1040                 1045                 1050             


Val Thr  Tyr Val Pro Ala Gln  Glu Lys Asn Phe Thr  Thr Ala Pro 
    1055                 1060                 1065             


Ala Ile  Cys His Asp Gly Lys  Ala His Phe Pro Arg  Glu Gly Val 
    1070                 1075                 1080             


Phe Val  Ser Asn Gly Thr His  Trp Phe Val Thr Gln  Arg Asn Phe 
    1085                 1090                 1095             


Tyr Glu  Pro Gln Ile Ile Thr  Thr Asp Asn Thr Phe  Val Ser Gly 
    1100                 1105                 1110             


Asn Cys  Asp Val Val Ile Gly  Ile Val Asn Asn Thr  Val Tyr Asp 
    1115                 1120                 1125             


Pro Leu  Gln Ser Glu Leu Asp  Ser Ile Lys Glu Glu  Leu Asp Lys 
    1130                 1135                 1140             


Ile His  Lys Asn Gly Ser Gly  Gly Ser Gly Asp Ile  Ile Lys Leu 
    1145                 1150                 1155             


Leu Asn  Glu Gln Val Asn Lys  Glu Met Gln Ser Ser  Asn Leu Tyr 
    1160                 1165                 1170             


Met Ser  Met Ser Ser Trp Cys  Tyr Thr His Ser Leu  Asp Gly Ala 
    1175                 1180                 1185             


Gly Leu  Phe Leu Phe Asp His  Ala Ala Glu Glu Tyr  Glu His Ala 
    1190                 1195                 1200             


Lys Lys  Leu Ile Ile Phe Leu  Asn Glu Asn Asn Val  Pro Val Gln 
    1205                 1210                 1215             


Leu Thr  Ser Ile Ser Ala Pro  Glu His Lys Phe Glu  Gly Leu Thr 
    1220                 1225                 1230             


Gln Ile  Phe Gln Lys Ala Tyr  Glu His Glu Gln His  Ile Ser Glu 
    1235                 1240                 1245             


Ser Ile  Asn Asn Ile Val Asp  His Ala Ile Lys Ser  Lys Asp His 
    1250                 1255                 1260             


Ala Thr  Phe Asn Phe Leu Gln  Trp Tyr Val Ala Glu  Gln His Glu 
    1265                 1270                 1275             


Glu Glu  Val Leu Phe Lys Asp  Ile Leu Asp Lys Ile  Glu Leu Ile 
    1280                 1285                 1290             


Gly Asn  Glu Asn His Gly Leu  Tyr Leu Ala Asp Gln  Tyr Val Lys 
    1295                 1300                 1305             


Gly Ile  Ala Lys Ser Arg Lys  Ser Gly Ser 
    1310                 1315             


<210> 145
<211> 1310
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 145
Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser 
1               5                   10                  15      


Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val 
            20                  25                  30          


Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr 
        35                  40                  45              


Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe 
    50                  55                  60                  


Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr 
65                  70                  75                  80  


Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp 
                85                  90                  95      


Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val 
            100                 105                 110         


Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val 
        115                 120                 125             


Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val 
    130                 135                 140                 


Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe 
145                 150                 155                 160 


Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu 
                165                 170                 175     


Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His 
            180                 185                 190         


Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu 
        195                 200                 205             


Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln 
    210                 215                 220                 


Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser 
225                 230                 235                 240 


Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln 
                245                 250                 255     


Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp 
            260                 265                 270         


Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu 
        275                 280                 285             


Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg 
    290                 295                 300                 


Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu 
305                 310                 315                 320 


Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr 
                325                 330                 335     


Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val 
            340                 345                 350         


Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Cys 
        355                 360                 365             


Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser 
    370                 375                 380                 


Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr 
385                 390                 395                 400 


Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly 
                405                 410                 415     


Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly 
            420                 425                 430         


Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro 
        435                 440                 445             


Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro 
    450                 455                 460                 


Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr 
465                 470                 475                 480 


Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val 
                485                 490                 495     


Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro 
            500                 505                 510         


Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe 
        515                 520                 525             


Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe 
    530                 535                 540                 


Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala 
545                 550                 555                 560 


Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser 
                565                 570                 575     


Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln 
            580                 585                 590         


Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala 
        595                 600                 605             


Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly 
    610                 615                 620                 


Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His 
625                 630                 635                 640 


Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys 
                645                 650                 655     


Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro Gly Ser Ala Ser Ser Val 
            660                 665                 670         


Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn 
        675                 680                 685             


Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr 
    690                 695                 700                 


Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser 
705                 710                 715                 720 


Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn 
                725                 730                 735     


Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu 
            740                 745                 750         


Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala 
        755                 760                 765             


Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly 
    770                 775                 780                 


Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg 
785                 790                 795                 800 


Ser Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala 
                805                 810                 815     


Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg 
            820                 825                 830         


Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro 
        835                 840                 845             


Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala 
    850                 855                 860                 


Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln 
865                 870                 875                 880 


Ile Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val 
                885                 890                 895     


Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe 
            900                 905                 910         


Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser 
        915                 920                 925             


Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu 
    930                 935                 940                 


Asn Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser 
945                 950                 955                 960 


Val Leu Asn Asp Ile Leu Ser Arg Leu Cys Pro Pro Glu Ala Glu Val 
                965                 970                 975     


Gln Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser Leu Gln Thr Tyr 
            980                 985                 990         


Val Thr Gln Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
        995                 1000                 1005             


Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1010                 1015                 1020             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1025                 1030                 1035             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1040                 1045                 1050             


Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1055                 1060                 1065             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1070                 1075                 1080             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1085                 1090                 1095             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1100                 1105                 1110             


Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro 
    1115                 1120                 1125             


Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Gly  Ser Gly Gly 
    1130                 1135                 1140             


Ser Gly  Asp Ile Ile Lys Leu  Leu Asn Glu Gln Val  Asn Lys Glu 
    1145                 1150                 1155             


Met Gln  Ser Ser Asn Leu Tyr  Met Ser Met Ser Ser  Trp Cys Tyr 
    1160                 1165                 1170             


Thr His  Ser Leu Asp Gly Ala  Gly Leu Phe Leu Phe  Asp His Ala 
    1175                 1180                 1185             


Ala Glu  Glu Tyr Glu His Ala  Lys Lys Leu Ile Ile  Phe Leu Asn 
    1190                 1195                 1200             


Glu Asn  Asn Val Pro Val Gln  Leu Thr Ser Ile Ser  Ala Pro Glu 
    1205                 1210                 1215             


His Lys  Phe Glu Gly Leu Thr  Gln Ile Phe Gln Lys  Ala Tyr Glu 
    1220                 1225                 1230             


His Glu  Gln His Ile Ser Glu  Ser Ile Asn Asn Ile  Val Asp His 
    1235                 1240                 1245             


Ala Ile  Lys Ser Lys Asp His  Ala Thr Phe Asn Phe  Leu Gln Trp 
    1250                 1255                 1260             


Tyr Val  Ala Glu Gln His Glu  Glu Glu Val Leu Phe  Lys Asp Ile 
    1265                 1270                 1275             


Leu Asp  Lys Ile Glu Leu Ile  Gly Asn Glu Asn His  Gly Leu Tyr 
    1280                 1285                 1290             


Leu Ala  Asp Gln Tyr Val Lys  Gly Ile Ala Lys Ser  Arg Lys Ser 
    1295                 1300                 1305             


Gly Ser  
    1310 


<210> 146
<211> 1318
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 146
Ser Ser Gln Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala 
1               5                   10                  15      


Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe 
            20                  25                  30          


Arg Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe 
        35                  40                  45              


Ser Asn Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly 
    50                  55                  60                  


Thr Lys Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr 
65                  70                  75                  80  


Phe Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly 
                85                  90                  95      


Thr Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala 
            100                 105                 110         


Thr Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro 
        115                 120                 125             


Phe Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser 
    130                 135                 140                 


Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val 
145                 150                 155                 160 


Ser Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys 
                165                 170                 175     


Asn Leu Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile 
            180                 185                 190         


Tyr Ser Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly 
        195                 200                 205             


Phe Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile 
    210                 215                 220                 


Thr Arg Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro 
225                 230                 235                 240 


Gly Asp Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val 
                245                 250                 255     


Gly Tyr Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly 
            260                 265                 270         


Thr Ile Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr 
        275                 280                 285             


Lys Cys Thr Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr 
    290                 295                 300                 


Ser Asn Phe Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn 
305                 310                 315                 320 


Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe 
                325                 330                 335     


Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala 
            340                 345                 350         


Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys 
        355                 360                 365             


Tyr Gly Val Cys Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val 
    370                 375                 380                 


Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala 
385                 390                 395                 400 


Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp 
                405                 410                 415     


Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser 
            420                 425                 430         


Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser 
        435                 440                 445             


Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala 
    450                 455                 460                 


Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro 
465                 470                 475                 480 


Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro 
                485                 490                 495     


Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr 
            500                 505                 510         


Val Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val 
        515                 520                 525             


Asn Phe Asn Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser 
    530                 535                 540                 


Asn Lys Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp 
545                 550                 555                 560 


Thr Thr Asp Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile 
                565                 570                 575     


Thr Pro Cys Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn 
            580                 585                 590         


Thr Ser Asn Gln Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu 
        595                 600                 605             


Val Pro Val Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val 
    610                 615                 620                 


Tyr Ser Thr Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile 
625                 630                 635                 640 


Gly Ala Glu His Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly 
                645                 650                 655     


Ala Gly Ile Cys Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro Gly Ser 
            660                 665                 670         


Ala Ser Ser Val Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu 
        675                 680                 685             


Gly Ala Glu Asn Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro 
    690                 695                 700                 


Thr Asn Phe Thr Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met 
705                 710                 715                 720 


Thr Lys Thr Ser Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr 
                725                 730                 735     


Glu Cys Ser Asn Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu 
            740                 745                 750         


Asn Arg Ala Leu Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln 
        755                 760                 765             


Glu Val Phe Ala Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys 
    770                 775                 780                 


Asp Phe Gly Gly Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys 
785                 790                 795                 800 


Pro Ser Lys Arg Ser Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr 
                805                 810                 815     


Leu Ala Asp Ala Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp 
            820                 825                 830         


Ile Ala Ala Arg Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr 
        835                 840                 845             


Val Leu Pro Pro Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser 
    850                 855                 860                 


Ala Leu Leu Ala Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly 
865                 870                 875                 880 


Ala Ala Leu Gln Ile Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn 
                885                 890                 895     


Gly Ile Gly Val Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile 
            900                 905                 910         


Ala Asn Gln Phe Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser 
        915                 920                 925             


Ser Thr Ala Ser Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn 
    930                 935                 940                 


Ala Gln Ala Leu Asn Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly 
945                 950                 955                 960 


Ala Ile Ser Ser Val Leu Asn Asp Ile Leu Ser Arg Leu Cys Pro Pro 
                965                 970                 975     


Glu Ala Glu Val Gln Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser 
            980                 985                 990         


Leu Gln Thr Tyr Val Thr Gln Gln  Leu Ile Arg Ala Ala  Glu Ile Arg 
        995                 1000                 1005             


Ala Ser  Ala Asn Leu Ala Ala  Thr Lys Met Ser Glu  Cys Val Leu 
    1010                 1015                 1020             


Gly Gln  Ser Lys Arg Val Asp  Phe Cys Gly Lys Gly  Tyr His Leu 
    1025                 1030                 1035             


Met Ser  Phe Pro Gln Ser Ala  Pro His Gly Val Val  Phe Leu His 
    1040                 1045                 1050             


Val Thr  Tyr Val Pro Ala Gln  Glu Lys Asn Phe Thr  Thr Ala Pro 
    1055                 1060                 1065             


Ala Ile  Cys His Asp Gly Lys  Ala His Phe Pro Arg  Glu Gly Val 
    1070                 1075                 1080             


Phe Val  Ser Asn Gly Thr His  Trp Phe Val Thr Gln  Arg Asn Phe 
    1085                 1090                 1095             


Tyr Glu  Pro Gln Ile Ile Thr  Thr Asp Asn Thr Phe  Val Ser Gly 
    1100                 1105                 1110             


Asn Cys  Asp Val Val Ile Gly  Ile Val Asn Asn Thr  Val Tyr Asp 
    1115                 1120                 1125             


Pro Leu  Gln Ser Glu Leu Asp  Ser Ile Lys Glu Glu  Leu Asp Lys 
    1130                 1135                 1140             


Ile His  Lys Asn Gly Ser Gly  Gly Ser Gly Asp Ile  Ile Lys Leu 
    1145                 1150                 1155             


Leu Asn  Glu Gln Val Asn Lys  Glu Met Gln Ser Ser  Asn Leu Tyr 
    1160                 1165                 1170             


Met Ser  Met Ser Ser Trp Cys  Tyr Thr His Ser Leu  Asp Gly Ala 
    1175                 1180                 1185             


Gly Leu  Phe Leu Phe Asp His  Ala Ala Glu Glu Tyr  Glu His Ala 
    1190                 1195                 1200             


Lys Lys  Leu Ile Ile Phe Leu  Asn Glu Asn Asn Val  Pro Val Gln 
    1205                 1210                 1215             


Leu Thr  Ser Ile Ser Ala Pro  Glu His Lys Phe Glu  Gly Leu Thr 
    1220                 1225                 1230             


Gln Ile  Phe Gln Lys Ala Tyr  Glu His Glu Gln His  Ile Ser Glu 
    1235                 1240                 1245             


Ser Ile  Asn Asn Ile Val Asp  His Ala Ile Lys Ser  Lys Asp His 
    1250                 1255                 1260             


Ala Thr  Phe Asn Phe Leu Gln  Trp Tyr Val Ala Glu  Gln His Glu 
    1265                 1270                 1275             


Glu Glu  Val Leu Phe Lys Asp  Ile Leu Asp Lys Ile  Glu Leu Ile 
    1280                 1285                 1290             


Gly Asn  Glu Asn His Gly Leu  Tyr Leu Ala Asp Gln  Tyr Val Lys 
    1295                 1300                 1305             


Gly Ile  Ala Lys Ser Arg Lys  Ser Gly Ser 
    1310                 1315             


<210> 147
<211> 1315
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 147
Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn 
1               5                   10                  15      


Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser 
            20                  25                  30          


Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val 
        35                  40                  45              


Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg 
    50                  55                  60                  


Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser 
65                  70                  75                  80  


Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu 
                85                  90                  95      


Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val 
            100                 105                 110         


Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly 
        115                 120                 125             


Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg 
    130                 135                 140                 


Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro 
145                 150                 155                 160 


Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg 
                165                 170                 175     


Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys 
            180                 185                 190         


His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala 
        195                 200                 205             


Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe 
    210                 215                 220                 


Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser 
225                 230                 235                 240 


Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu 
                245                 250                 255     


Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr 
            260                 265                 270         


Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr 
        275                 280                 285             


Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe 
    290                 295                 300                 


Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn 
305                 310                 315                 320 


Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val 
                325                 330                 335     


Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser 
            340                 345                 350         


Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val 
        355                 360                 365             


Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp 
    370                 375                 380                 


Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln 
385                 390                 395                 400 


Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr 
                405                 410                 415     


Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly 
            420                 425                 430         


Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys 
        435                 440                 445             


Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr 
    450                 455                 460                 


Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser 
465                 470                 475                 480 


Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val 
                485                 490                 495     


Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly 
            500                 505                 510         


Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn 
        515                 520                 525             


Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys 
    530                 535                 540                 


Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp 
545                 550                 555                 560 


Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys 
                565                 570                 575     


Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn 
            580                 585                 590         


Gln Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val 
        595                 600                 605             


Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr 
    610                 615                 620                 


Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu 
625                 630                 635                 640 


His Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile 
                645                 650                 655     


Cys Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro Gly Ser Ala Ser Ser 
            660                 665                 670         


Val Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu 
        675                 680                 685             


Asn Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe 
    690                 695                 700                 


Thr Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr 
705                 710                 715                 720 


Ser Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser 
                725                 730                 735     


Asn Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala 
            740                 745                 750         


Leu Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe 
        755                 760                 765             


Ala Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly 
    770                 775                 780                 


Gly Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys 
785                 790                 795                 800 


Arg Ser Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp 
                805                 810                 815     


Ala Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala 
            820                 825                 830         


Arg Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro 
        835                 840                 845             


Pro Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu 
    850                 855                 860                 


Ala Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu 
865                 870                 875                 880 


Gln Ile Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly 
                885                 890                 895     


Val Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln 
            900                 905                 910         


Phe Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala 
        915                 920                 925             


Ser Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala 
    930                 935                 940                 


Leu Asn Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser 
945                 950                 955                 960 


Ser Val Leu Asn Asp Ile Leu Ser Arg Leu Asp Pro Pro Glu Ala Glu 
                965                 970                 975     


Val Gln Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser Leu Gln Thr 
            980                 985                 990         


Tyr Val Thr Gln Gln Leu Ile Arg  Ala Ala Glu Ile Arg  Ala Ser Ala 
        995                 1000                 1005             


Asn Leu  Ala Ala Thr Lys Met  Ser Glu Cys Val Leu  Gly Gln Ser 
    1010                 1015                 1020             


Lys Arg  Val Asp Phe Cys Gly  Lys Gly Tyr His Leu  Met Ser Phe 
    1025                 1030                 1035             


Pro Gln  Ser Ala Pro His Gly  Val Val Phe Leu His  Val Thr Tyr 
    1040                 1045                 1050             


Val Pro  Ala Gln Glu Lys Asn  Phe Thr Thr Ala Pro  Ala Ile Cys 
    1055                 1060                 1065             


His Asp  Gly Lys Ala His Phe  Pro Arg Glu Gly Val  Phe Val Ser 
    1070                 1075                 1080             


Asn Gly  Thr His Trp Phe Val  Thr Gln Arg Asn Phe  Tyr Glu Pro 
    1085                 1090                 1095             


Gln Ile  Ile Thr Thr Asp Asn  Thr Phe Val Ser Gly  Asn Cys Asp 
    1100                 1105                 1110             


Val Val  Ile Gly Ile Val Asn  Asn Thr Val Tyr Asp  Pro Leu Gln 
    1115                 1120                 1125             


Ser Glu  Leu Asp Ser Ile Lys  Glu Glu Leu Asp Lys  Ile His Lys 
    1130                 1135                 1140             


Asn Gly  Ser Gly Gly Ser Gly  Asp Ile Ile Lys Leu  Leu Asn Glu 
    1145                 1150                 1155             


Gln Val  Asn Lys Glu Met Gln  Ser Ser Asn Leu Tyr  Met Ser Met 
    1160                 1165                 1170             


Ser Ser  Trp Cys Tyr Thr His  Ser Leu Asp Gly Ala  Gly Leu Phe 
    1175                 1180                 1185             


Leu Phe  Asp His Ala Ala Glu  Glu Tyr Glu His Ala  Lys Lys Leu 
    1190                 1195                 1200             


Ile Ile  Phe Leu Asn Glu Asn  Asn Val Pro Val Gln  Leu Thr Ser 
    1205                 1210                 1215             


Ile Ser  Ala Pro Glu His Lys  Phe Glu Gly Leu Thr  Gln Ile Phe 
    1220                 1225                 1230             


Gln Lys  Ala Tyr Glu His Glu  Gln His Ile Ser Glu  Ser Ile Asn 
    1235                 1240                 1245             


Asn Ile  Val Asp His Ala Ile  Lys Ser Lys Asp His  Ala Thr Phe 
    1250                 1255                 1260             


Asn Phe  Leu Gln Trp Tyr Val  Ala Glu Gln His Glu  Glu Glu Val 
    1265                 1270                 1275             


Leu Phe  Lys Asp Ile Leu Asp  Lys Ile Glu Leu Ile  Gly Asn Glu 
    1280                 1285                 1290             


Asn His  Gly Leu Tyr Leu Ala  Asp Gln Tyr Val Lys  Gly Ile Ala 
    1295                 1300                 1305             


Lys Ser  Arg Lys Ser Gly Ser  
    1310                 1315 


<210> 148
<211> 1320
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 148
Glu Thr Gly Thr Gln Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro 
1               5                   10                  15      


Pro Ala Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys 
            20                  25                  30          


Val Phe Arg Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro 
        35                  40                  45              


Phe Phe Ser Asn Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr 
    50                  55                  60                  


Asn Gly Thr Lys Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly 
65                  70                  75                  80  


Val Tyr Phe Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile 
                85                  90                  95      


Phe Gly Thr Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn 
            100                 105                 110         


Asn Ala Thr Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn 
        115                 120                 125             


Asp Pro Phe Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met 
    130                 135                 140                 


Glu Ser Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu 
145                 150                 155                 160 


Tyr Val Ser Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn 
                165                 170                 175     


Phe Lys Asn Leu Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe 
            180                 185                 190         


Lys Ile Tyr Ser Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro 
        195                 200                 205             


Gln Gly Phe Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile 
    210                 215                 220                 


Asn Ile Thr Arg Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu 
225                 230                 235                 240 


Thr Pro Gly Asp Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr 
                245                 250                 255     


Tyr Val Gly Tyr Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu 
            260                 265                 270         


Asn Gly Thr Ile Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser 
        275                 280                 285             


Glu Thr Lys Cys Thr Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr 
    290                 295                 300                 


Gln Thr Ser Asn Phe Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe 
305                 310                 315                 320 


Pro Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr 
                325                 330                 335     


Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys 
            340                 345                 350         


Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe 
        355                 360                 365             


Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr 
    370                 375                 380                 


Asn Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln 
385                 390                 395                 400 


Ile Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu 
                405                 410                 415     


Pro Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu 
            420                 425                 430         


Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg 
        435                 440                 445             


Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr 
    450                 455                 460                 


Gln Ala Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr 
465                 470                 475                 480 


Phe Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr 
                485                 490                 495     


Gln Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro 
            500                 505                 510         


Ala Thr Val Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys 
        515                 520                 525             


Cys Val Asn Phe Asn Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr 
    530                 535                 540                 


Glu Ser Asn Lys Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile 
545                 550                 555                 560 


Ala Asp Thr Thr Asp Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu 
                565                 570                 575     


Asp Ile Thr Pro Cys Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly 
            580                 585                 590         


Thr Asn Thr Ser Asn Gln Val Ala Val Leu Tyr Gln Asp Val Asn Cys 
        595                 600                 605             


Thr Glu Val Pro Val Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp 
    610                 615                 620                 


Arg Val Tyr Ser Thr Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys 
625                 630                 635                 640 


Leu Ile Gly Ala Glu His Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro 
                645                 650                 655     


Ile Gly Ala Gly Ile Cys Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro 
            660                 665                 670         


Gly Ser Ala Ser Ser Val Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met 
        675                 680                 685             


Ser Leu Gly Ala Glu Asn Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala 
    690                 695                 700                 


Ile Pro Thr Asn Phe Thr Ile Ser Val Thr Thr Glu Ile Leu Pro Val 
705                 710                 715                 720 


Ser Met Thr Lys Thr Ser Val Asp Cys Thr Met Tyr Ile Cys Gly Asp 
                725                 730                 735     


Ser Thr Glu Cys Ser Asn Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr 
            740                 745                 750         


Gln Leu Asn Arg Ala Leu Thr Gly Ile Ala Val Glu Gln Asp Lys Asn 
        755                 760                 765             


Thr Gln Glu Val Phe Ala Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro 
    770                 775                 780                 


Ile Lys Asp Phe Gly Gly Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro 
785                 790                 795                 800 


Ser Lys Pro Ser Lys Arg Ser Phe Ile Glu Asp Leu Leu Phe Asn Lys 
                805                 810                 815     


Val Thr Leu Ala Asp Ala Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu 
            820                 825                 830         


Gly Asp Ile Ala Ala Arg Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly 
        835                 840                 845             


Leu Thr Val Leu Pro Pro Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr 
    850                 855                 860                 


Thr Ser Ala Leu Leu Ala Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly 
865                 870                 875                 880 


Ala Gly Ala Ala Leu Gln Ile Pro Phe Ala Met Gln Met Ala Tyr Arg 
                885                 890                 895     


Phe Asn Gly Ile Gly Val Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys 
            900                 905                 910         


Leu Ile Ala Asn Gln Phe Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser 
        915                 920                 925             


Leu Ser Ser Thr Ala Ser Ala Leu Gly Lys Leu Gln Asp Val Val Asn 
    930                 935                 940                 


Gln Asn Ala Gln Ala Leu Asn Thr Leu Val Lys Gln Leu Ser Ser Asn 
945                 950                 955                 960 


Phe Gly Ala Ile Ser Ser Val Leu Asn Asp Ile Leu Ser Arg Leu Asp 
                965                 970                 975     


Pro Pro Glu Ala Glu Val Gln Ile Asp Arg Leu Ile Thr Gly Arg Leu 
            980                 985                 990         


Gln Ser Leu Gln Thr Tyr Val Thr  Gln Gln Leu Ile Arg  Ala Ala Glu 
        995                 1000                 1005             


Ile Arg  Ala Ser Ala Asn Leu  Ala Ala Thr Lys Met  Ser Glu Cys 
    1010                 1015                 1020             


Val Leu  Gly Gln Ser Lys Arg  Val Asp Phe Cys Gly  Lys Gly Tyr 
    1025                 1030                 1035             


His Leu  Met Ser Phe Pro Gln  Ser Ala Pro His Gly  Val Val Phe 
    1040                 1045                 1050             


Leu His  Val Thr Tyr Val Pro  Ala Gln Glu Lys Asn  Phe Thr Thr 
    1055                 1060                 1065             


Ala Pro  Ala Ile Cys His Asp  Gly Lys Ala His Phe  Pro Arg Glu 
    1070                 1075                 1080             


Gly Val  Phe Val Ser Asn Gly  Thr His Trp Phe Val  Thr Gln Arg 
    1085                 1090                 1095             


Asn Phe  Tyr Glu Pro Gln Ile  Ile Thr Thr Asp Asn  Thr Phe Val 
    1100                 1105                 1110             


Ser Gly  Asn Cys Asp Val Val  Ile Gly Ile Val Asn  Asn Thr Val 
    1115                 1120                 1125             


Tyr Asp  Pro Leu Gln Ser Glu  Leu Asp Ser Ile Lys  Glu Glu Leu 
    1130                 1135                 1140             


Asp Lys  Ile His Lys Asn Gly  Ser Gly Gly Ser Gly  Asp Ile Ile 
    1145                 1150                 1155             


Lys Leu  Leu Asn Glu Gln Val  Asn Lys Glu Met Gln  Ser Ser Asn 
    1160                 1165                 1170             


Leu Tyr  Met Ser Met Ser Ser  Trp Cys Tyr Thr His  Ser Leu Asp 
    1175                 1180                 1185             


Gly Ala  Gly Leu Phe Leu Phe  Asp His Ala Ala Glu  Glu Tyr Glu 
    1190                 1195                 1200             


His Ala  Lys Lys Leu Ile Ile  Phe Leu Asn Glu Asn  Asn Val Pro 
    1205                 1210                 1215             


Val Gln  Leu Thr Ser Ile Ser  Ala Pro Glu His Lys  Phe Glu Gly 
    1220                 1225                 1230             


Leu Thr  Gln Ile Phe Gln Lys  Ala Tyr Glu His Glu  Gln His Ile 
    1235                 1240                 1245             


Ser Glu  Ser Ile Asn Asn Ile  Val Asp His Ala Ile  Lys Ser Lys 
    1250                 1255                 1260             


Asp His  Ala Thr Phe Asn Phe  Leu Gln Trp Tyr Val  Ala Glu Gln 
    1265                 1270                 1275             


His Glu  Glu Glu Val Leu Phe  Lys Asp Ile Leu Asp  Lys Ile Glu 
    1280                 1285                 1290             


Leu Ile  Gly Asn Glu Asn His  Gly Leu Tyr Leu Ala  Asp Gln Tyr 
    1295                 1300                 1305             


Val Lys  Gly Ile Ala Lys Ser  Arg Lys Ser Gly Ser  
    1310                 1315                 1320 


<210> 149
<211> 1320
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 149
Ser Asp Leu Asp Arg Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro 
1               5                   10                  15      


Pro Ala Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys 
            20                  25                  30          


Val Phe Arg Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro 
        35                  40                  45              


Phe Phe Ser Asn Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr 
    50                  55                  60                  


Asn Gly Thr Lys Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly 
65                  70                  75                  80  


Val Tyr Phe Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile 
                85                  90                  95      


Phe Gly Thr Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn 
            100                 105                 110         


Asn Ala Thr Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn 
        115                 120                 125             


Asp Pro Phe Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met 
    130                 135                 140                 


Glu Ser Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu 
145                 150                 155                 160 


Tyr Val Ser Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn 
                165                 170                 175     


Phe Lys Asn Leu Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe 
            180                 185                 190         


Lys Ile Tyr Ser Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro 
        195                 200                 205             


Gln Gly Phe Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile 
    210                 215                 220                 


Asn Ile Thr Arg Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu 
225                 230                 235                 240 


Thr Pro Gly Asp Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr 
                245                 250                 255     


Tyr Val Gly Tyr Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu 
            260                 265                 270         


Asn Gly Thr Ile Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser 
        275                 280                 285             


Glu Thr Lys Cys Thr Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr 
    290                 295                 300                 


Gln Thr Ser Asn Phe Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe 
305                 310                 315                 320 


Pro Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr 
                325                 330                 335     


Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys 
            340                 345                 350         


Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe 
        355                 360                 365             


Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr 
    370                 375                 380                 


Asn Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln 
385                 390                 395                 400 


Ile Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu 
                405                 410                 415     


Pro Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu 
            420                 425                 430         


Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg 
        435                 440                 445             


Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr 
    450                 455                 460                 


Gln Ala Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr 
465                 470                 475                 480 


Phe Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr 
                485                 490                 495     


Gln Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro 
            500                 505                 510         


Ala Thr Val Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys 
        515                 520                 525             


Cys Val Asn Phe Asn Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr 
    530                 535                 540                 


Glu Ser Asn Lys Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile 
545                 550                 555                 560 


Ala Asp Thr Thr Asp Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu 
                565                 570                 575     


Asp Ile Thr Pro Cys Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly 
            580                 585                 590         


Thr Asn Thr Ser Asn Gln Val Ala Val Leu Tyr Gln Asp Val Asn Cys 
        595                 600                 605             


Thr Glu Val Pro Val Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp 
    610                 615                 620                 


Arg Val Tyr Ser Thr Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys 
625                 630                 635                 640 


Leu Ile Gly Ala Glu His Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro 
                645                 650                 655     


Ile Gly Ala Gly Ile Cys Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro 
            660                 665                 670         


Gly Ser Ala Ser Ser Val Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met 
        675                 680                 685             


Ser Leu Gly Ala Glu Asn Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala 
    690                 695                 700                 


Ile Pro Thr Asn Phe Thr Ile Ser Val Thr Thr Glu Ile Leu Pro Val 
705                 710                 715                 720 


Ser Met Thr Lys Thr Ser Val Asp Cys Thr Met Tyr Ile Cys Gly Asp 
                725                 730                 735     


Ser Thr Glu Cys Ser Asn Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr 
            740                 745                 750         


Gln Leu Asn Arg Ala Leu Thr Gly Ile Ala Val Glu Gln Asp Lys Asn 
        755                 760                 765             


Thr Gln Glu Val Phe Ala Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro 
    770                 775                 780                 


Ile Lys Asp Phe Gly Gly Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro 
785                 790                 795                 800 


Ser Lys Pro Ser Lys Arg Ser Phe Ile Glu Asp Leu Leu Phe Asn Lys 
                805                 810                 815     


Val Thr Leu Ala Asp Ala Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu 
            820                 825                 830         


Gly Asp Ile Ala Ala Arg Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly 
        835                 840                 845             


Leu Thr Val Leu Pro Pro Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr 
    850                 855                 860                 


Thr Ser Ala Leu Leu Ala Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly 
865                 870                 875                 880 


Ala Gly Ala Ala Leu Gln Ile Pro Phe Ala Met Gln Met Ala Tyr Arg 
                885                 890                 895     


Phe Asn Gly Ile Gly Val Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys 
            900                 905                 910         


Leu Ile Ala Asn Gln Phe Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser 
        915                 920                 925             


Leu Ser Ser Thr Ala Ser Ala Leu Gly Lys Leu Gln Asp Val Val Asn 
    930                 935                 940                 


Gln Asn Ala Gln Ala Leu Asn Thr Leu Val Lys Gln Leu Ser Ser Asn 
945                 950                 955                 960 


Phe Gly Ala Ile Ser Ser Val Leu Asn Asp Ile Leu Ser Arg Leu Asp 
                965                 970                 975     


Pro Pro Glu Ala Glu Val Gln Ile Asp Arg Leu Ile Thr Gly Arg Leu 
            980                 985                 990         


Gln Ser Leu Gln Thr Tyr Val Thr  Gln Gln Leu Ile Arg  Ala Ala Glu 
        995                 1000                 1005             


Ile Arg  Ala Ser Ala Asn Leu  Ala Ala Thr Lys Met  Ser Glu Cys 
    1010                 1015                 1020             


Val Leu  Gly Gln Ser Lys Arg  Val Asp Phe Cys Gly  Lys Gly Tyr 
    1025                 1030                 1035             


His Leu  Met Ser Phe Pro Gln  Ser Ala Pro His Gly  Val Val Phe 
    1040                 1045                 1050             


Leu His  Val Thr Tyr Val Pro  Ala Gln Glu Lys Asn  Phe Thr Thr 
    1055                 1060                 1065             


Ala Pro  Ala Ile Cys His Asp  Gly Lys Ala His Phe  Pro Arg Glu 
    1070                 1075                 1080             


Gly Val  Phe Val Ser Asn Gly  Thr His Trp Phe Val  Thr Gln Arg 
    1085                 1090                 1095             


Asn Phe  Tyr Glu Pro Gln Ile  Ile Thr Thr Asp Asn  Thr Phe Val 
    1100                 1105                 1110             


Ser Gly  Asn Cys Asp Val Val  Ile Gly Ile Val Asn  Asn Thr Val 
    1115                 1120                 1125             


Tyr Asp  Pro Leu Gln Ser Glu  Leu Asp Ser Ile Lys  Glu Glu Leu 
    1130                 1135                 1140             


Asp Lys  Ile His Lys Asn Gly  Ser Gly Gly Ser Gly  Asp Ile Ile 
    1145                 1150                 1155             


Lys Leu  Leu Asn Glu Gln Val  Asn Lys Glu Met Gln  Ser Ser Asn 
    1160                 1165                 1170             


Leu Tyr  Met Ser Met Ser Ser  Trp Cys Tyr Thr His  Ser Leu Asp 
    1175                 1180                 1185             


Gly Ala  Gly Leu Phe Leu Phe  Asp His Ala Ala Glu  Glu Tyr Glu 
    1190                 1195                 1200             


His Ala  Lys Lys Leu Ile Ile  Phe Leu Asn Glu Asn  Asn Val Pro 
    1205                 1210                 1215             


Val Gln  Leu Thr Ser Ile Ser  Ala Pro Glu His Lys  Phe Glu Gly 
    1220                 1225                 1230             


Leu Thr  Gln Ile Phe Gln Lys  Ala Tyr Glu His Glu  Gln His Ile 
    1235                 1240                 1245             


Ser Glu  Ser Ile Asn Asn Ile  Val Asp His Ala Ile  Lys Ser Lys 
    1250                 1255                 1260             


Asp His  Ala Thr Phe Asn Phe  Leu Gln Trp Tyr Val  Ala Glu Gln 
    1265                 1270                 1275             


His Glu  Glu Glu Val Leu Phe  Lys Asp Ile Leu Asp  Lys Ile Glu 
    1280                 1285                 1290             


Leu Ile  Gly Asn Glu Asn His  Gly Leu Tyr Leu Ala  Asp Gln Tyr 
    1295                 1300                 1305             


Val Lys  Gly Ile Ala Lys Ser  Arg Lys Ser Gly Ser  
    1310                 1315                 1320 


<210> 150
<211> 1318
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 150
Ser Ser Gln Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala 
1               5                   10                  15      


Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe 
            20                  25                  30          


Arg Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe 
        35                  40                  45              


Ser Asn Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly 
    50                  55                  60                  


Thr Lys Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr 
65                  70                  75                  80  


Phe Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly 
                85                  90                  95      


Thr Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala 
            100                 105                 110         


Thr Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro 
        115                 120                 125             


Phe Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser 
    130                 135                 140                 


Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val 
145                 150                 155                 160 


Ser Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys 
                165                 170                 175     


Asn Leu Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile 
            180                 185                 190         


Tyr Ser Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly 
        195                 200                 205             


Phe Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile 
    210                 215                 220                 


Thr Arg Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro 
225                 230                 235                 240 


Gly Asp Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val 
                245                 250                 255     


Gly Tyr Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly 
            260                 265                 270         


Thr Ile Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr 
        275                 280                 285             


Lys Cys Thr Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr 
    290                 295                 300                 


Ser Asn Phe Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn 
305                 310                 315                 320 


Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe 
                325                 330                 335     


Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala 
            340                 345                 350         


Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys 
        355                 360                 365             


Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val 
    370                 375                 380                 


Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala 
385                 390                 395                 400 


Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp 
                405                 410                 415     


Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser 
            420                 425                 430         


Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser 
        435                 440                 445             


Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala 
    450                 455                 460                 


Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro 
465                 470                 475                 480 


Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro 
                485                 490                 495     


Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr 
            500                 505                 510         


Val Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val 
        515                 520                 525             


Asn Phe Asn Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser 
    530                 535                 540                 


Asn Lys Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp 
545                 550                 555                 560 


Thr Thr Asp Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile 
                565                 570                 575     


Thr Pro Cys Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn 
            580                 585                 590         


Thr Ser Asn Gln Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu 
        595                 600                 605             


Val Pro Val Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val 
    610                 615                 620                 


Tyr Ser Thr Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile 
625                 630                 635                 640 


Gly Ala Glu His Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly 
                645                 650                 655     


Ala Gly Ile Cys Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro Gly Ser 
            660                 665                 670         


Ala Ser Ser Val Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu 
        675                 680                 685             


Gly Ala Glu Asn Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro 
    690                 695                 700                 


Thr Asn Phe Thr Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met 
705                 710                 715                 720 


Thr Lys Thr Ser Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr 
                725                 730                 735     


Glu Cys Ser Asn Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu 
            740                 745                 750         


Asn Arg Ala Leu Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln 
        755                 760                 765             


Glu Val Phe Ala Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys 
    770                 775                 780                 


Asp Phe Gly Gly Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys 
785                 790                 795                 800 


Pro Ser Lys Arg Ser Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr 
                805                 810                 815     


Leu Ala Asp Ala Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp 
            820                 825                 830         


Ile Ala Ala Arg Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr 
        835                 840                 845             


Val Leu Pro Pro Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser 
    850                 855                 860                 


Ala Leu Leu Ala Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly 
865                 870                 875                 880 


Ala Ala Leu Gln Ile Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn 
                885                 890                 895     


Gly Ile Gly Val Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile 
            900                 905                 910         


Ala Asn Gln Phe Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser 
        915                 920                 925             


Ser Thr Ala Ser Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn 
    930                 935                 940                 


Ala Gln Ala Leu Asn Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly 
945                 950                 955                 960 


Ala Ile Ser Ser Val Leu Asn Asp Ile Leu Ser Arg Leu Asp Pro Pro 
                965                 970                 975     


Glu Ala Glu Val Gln Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser 
            980                 985                 990         


Leu Gln Thr Tyr Val Thr Gln Gln  Leu Ile Arg Ala Ala  Glu Ile Arg 
        995                 1000                 1005             


Ala Ser  Ala Asn Leu Ala Ala  Thr Lys Met Ser Glu  Cys Val Leu 
    1010                 1015                 1020             


Gly Gln  Ser Lys Arg Val Asp  Phe Cys Gly Lys Gly  Tyr His Leu 
    1025                 1030                 1035             


Met Ser  Phe Pro Gln Ser Ala  Pro His Gly Val Val  Phe Leu His 
    1040                 1045                 1050             


Val Thr  Tyr Val Pro Ala Gln  Glu Lys Asn Phe Thr  Thr Ala Pro 
    1055                 1060                 1065             


Ala Ile  Cys His Asp Gly Lys  Ala His Phe Pro Arg  Glu Gly Val 
    1070                 1075                 1080             


Phe Val  Ser Asn Gly Thr His  Trp Phe Val Thr Gln  Arg Asn Phe 
    1085                 1090                 1095             


Tyr Glu  Pro Gln Ile Ile Thr  Thr Asp Asn Thr Phe  Val Ser Gly 
    1100                 1105                 1110             


Asn Cys  Asp Val Val Ile Gly  Ile Val Asn Asn Thr  Val Tyr Asp 
    1115                 1120                 1125             


Pro Leu  Gln Pro Glu Leu Asp  Ser Phe Lys Glu Glu  Leu Asp Lys 
    1130                 1135                 1140             


Tyr Phe  Lys Asn Gly Ser Gly  Gly Ser Gly Asp Ile  Ile Lys Leu 
    1145                 1150                 1155             


Leu Asn  Glu Gln Val Asn Lys  Glu Met Gln Ser Ser  Asn Leu Tyr 
    1160                 1165                 1170             


Met Ser  Met Ser Ser Trp Cys  Tyr Thr His Ser Leu  Asp Gly Ala 
    1175                 1180                 1185             


Gly Leu  Phe Leu Phe Asp His  Ala Ala Glu Glu Tyr  Glu His Ala 
    1190                 1195                 1200             


Lys Lys  Leu Ile Ile Phe Leu  Asn Glu Asn Asn Val  Pro Val Gln 
    1205                 1210                 1215             


Leu Thr  Ser Ile Ser Ala Pro  Glu His Lys Phe Glu  Gly Leu Thr 
    1220                 1225                 1230             


Gln Ile  Phe Gln Lys Ala Tyr  Glu His Glu Gln His  Ile Ser Glu 
    1235                 1240                 1245             


Ser Ile  Asn Asn Ile Val Asp  His Ala Ile Lys Ser  Lys Asp His 
    1250                 1255                 1260             


Ala Thr  Phe Asn Phe Leu Gln  Trp Tyr Val Ala Glu  Gln His Glu 
    1265                 1270                 1275             


Glu Glu  Val Leu Phe Lys Asp  Ile Leu Asp Lys Ile  Glu Leu Ile 
    1280                 1285                 1290             


Gly Asn  Glu Asn His Gly Leu  Tyr Leu Ala Asp Gln  Tyr Val Lys 
    1295                 1300                 1305             


Gly Ile  Ala Lys Ser Arg Lys  Ser Gly Ser 
    1310                 1315             


<210> 151
<211> 1318
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 151
Ser Ser Gln Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala 
1               5                   10                  15      


Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe 
            20                  25                  30          


Arg Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe 
        35                  40                  45              


Ser Asn Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly 
    50                  55                  60                  


Thr Lys Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr 
65                  70                  75                  80  


Phe Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly 
                85                  90                  95      


Thr Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala 
            100                 105                 110         


Thr Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro 
        115                 120                 125             


Phe Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser 
    130                 135                 140                 


Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val 
145                 150                 155                 160 


Ser Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys 
                165                 170                 175     


Asn Leu Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile 
            180                 185                 190         


Tyr Ser Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly 
        195                 200                 205             


Phe Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile 
    210                 215                 220                 


Thr Arg Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro 
225                 230                 235                 240 


Gly Asp Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val 
                245                 250                 255     


Gly Tyr Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly 
            260                 265                 270         


Thr Ile Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr 
        275                 280                 285             


Lys Cys Thr Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr 
    290                 295                 300                 


Ser Asn Phe Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn 
305                 310                 315                 320 


Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe 
                325                 330                 335     


Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala 
            340                 345                 350         


Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys 
        355                 360                 365             


Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val 
    370                 375                 380                 


Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala 
385                 390                 395                 400 


Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp 
                405                 410                 415     


Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser 
            420                 425                 430         


Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser 
        435                 440                 445             


Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala 
    450                 455                 460                 


Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro 
465                 470                 475                 480 


Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro 
                485                 490                 495     


Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr 
            500                 505                 510         


Val Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val 
        515                 520                 525             


Asn Phe Asn Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser 
    530                 535                 540                 


Asn Lys Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp 
545                 550                 555                 560 


Thr Thr Asp Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile 
                565                 570                 575     


Thr Pro Cys Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn 
            580                 585                 590         


Thr Ser Asn Gln Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu 
        595                 600                 605             


Val Pro Val Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val 
    610                 615                 620                 


Tyr Ser Thr Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile 
625                 630                 635                 640 


Gly Ala Glu His Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly 
                645                 650                 655     


Ala Gly Ile Cys Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro Gly Ser 
            660                 665                 670         


Ala Ser Ser Val Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu 
        675                 680                 685             


Gly Ala Glu Asn Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro 
    690                 695                 700                 


Thr Asn Phe Thr Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met 
705                 710                 715                 720 


Thr Lys Thr Ser Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr 
                725                 730                 735     


Glu Cys Ser Asn Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu 
            740                 745                 750         


Asn Arg Ala Leu Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln 
        755                 760                 765             


Glu Val Phe Ala Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys 
    770                 775                 780                 


Asp Phe Gly Gly Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys 
785                 790                 795                 800 


Pro Ser Lys Arg Ser Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr 
                805                 810                 815     


Leu Ala Asp Ala Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp 
            820                 825                 830         


Ile Ala Ala Arg Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr 
        835                 840                 845             


Val Leu Pro Pro Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser 
    850                 855                 860                 


Ala Leu Leu Ala Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly 
865                 870                 875                 880 


Ala Ala Leu Gln Ile Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn 
                885                 890                 895     


Gly Ile Gly Val Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile 
            900                 905                 910         


Ala Asn Gln Phe Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser 
        915                 920                 925             


Ser Thr Ala Ser Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn 
    930                 935                 940                 


Ala Gln Ala Leu Asn Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly 
945                 950                 955                 960 


Ala Ile Ser Ser Val Leu Asn Asp Ile Leu Ser Arg Leu Asp Pro Pro 
                965                 970                 975     


Glu Ala Glu Val Gln Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser 
            980                 985                 990         


Leu Gln Thr Tyr Val Thr Gln Gln  Leu Ile Arg Ala Ala  Glu Ile Arg 
        995                 1000                 1005             


Ala Ser  Ala Asn Leu Ala Ala  Thr Lys Met Ser Glu  Cys Val Leu 
    1010                 1015                 1020             


Gly Gln  Ser Lys Arg Val Asp  Phe Cys Gly Lys Gly  Tyr His Leu 
    1025                 1030                 1035             


Met Ser  Phe Pro Gln Ser Ala  Pro His Gly Val Val  Phe Leu His 
    1040                 1045                 1050             


Val Thr  Tyr Val Pro Ala Gln  Glu Lys Asn Phe Thr  Thr Ala Pro 
    1055                 1060                 1065             


Ala Ile  Cys His Asp Gly Lys  Ala His Phe Pro Arg  Glu Gly Val 
    1070                 1075                 1080             


Phe Val  Ser Asn Gly Thr His  Trp Phe Val Thr Gln  Arg Asn Phe 
    1085                 1090                 1095             


Tyr Glu  Pro Gln Ile Ile Thr  Thr Asp Asn Thr Phe  Val Ser Gly 
    1100                 1105                 1110             


Asn Cys  Asp Val Val Ile Gly  Ile Val Asn Asn Thr  Val Tyr Asp 
    1115                 1120                 1125             


Pro Leu  Gln Pro Glu Leu Asp  Ser Ile Lys Glu Glu  Leu Asp Lys 
    1130                 1135                 1140             


Tyr Phe  Lys Asn Gly Ser Gly  Gly Ser Gly Asp Ile  Ile Lys Leu 
    1145                 1150                 1155             


Leu Asn  Glu Gln Val Asn Lys  Glu Met Gln Ser Ser  Asn Leu Tyr 
    1160                 1165                 1170             


Met Ser  Met Ser Ser Trp Cys  Tyr Thr His Ser Leu  Asp Gly Ala 
    1175                 1180                 1185             


Gly Leu  Phe Leu Phe Asp His  Ala Ala Glu Glu Tyr  Glu His Ala 
    1190                 1195                 1200             


Lys Lys  Leu Ile Ile Phe Leu  Asn Glu Asn Asn Val  Pro Val Gln 
    1205                 1210                 1215             


Leu Thr  Ser Ile Ser Ala Pro  Glu His Lys Phe Glu  Gly Leu Thr 
    1220                 1225                 1230             


Gln Ile  Phe Gln Lys Ala Tyr  Glu His Glu Gln His  Ile Ser Glu 
    1235                 1240                 1245             


Ser Ile  Asn Asn Ile Val Asp  His Ala Ile Lys Ser  Lys Asp His 
    1250                 1255                 1260             


Ala Thr  Phe Asn Phe Leu Gln  Trp Tyr Val Ala Glu  Gln His Glu 
    1265                 1270                 1275             


Glu Glu  Val Leu Phe Lys Asp  Ile Leu Asp Lys Ile  Glu Leu Ile 
    1280                 1285                 1290             


Gly Asn  Glu Asn His Gly Leu  Tyr Leu Ala Asp Gln  Tyr Val Lys 
    1295                 1300                 1305             


Gly Ile  Ala Lys Ser Arg Lys  Ser Gly Ser 
    1310                 1315             


<210> 152
<211> 1318
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 152
Ser Ser Gln Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala 
1               5                   10                  15      


Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe 
            20                  25                  30          


Arg Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe 
        35                  40                  45              


Ser Asn Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly 
    50                  55                  60                  


Thr Lys Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr 
65                  70                  75                  80  


Phe Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly 
                85                  90                  95      


Thr Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala 
            100                 105                 110         


Thr Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro 
        115                 120                 125             


Phe Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser 
    130                 135                 140                 


Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val 
145                 150                 155                 160 


Ser Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys 
                165                 170                 175     


Asn Leu Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile 
            180                 185                 190         


Tyr Ser Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly 
        195                 200                 205             


Phe Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile 
    210                 215                 220                 


Thr Arg Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro 
225                 230                 235                 240 


Gly Asp Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val 
                245                 250                 255     


Gly Tyr Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly 
            260                 265                 270         


Thr Ile Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr 
        275                 280                 285             


Lys Cys Thr Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr 
    290                 295                 300                 


Ser Asn Phe Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn 
305                 310                 315                 320 


Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe 
                325                 330                 335     


Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala 
            340                 345                 350         


Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys 
        355                 360                 365             


Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val 
    370                 375                 380                 


Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala 
385                 390                 395                 400 


Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp 
                405                 410                 415     


Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser 
            420                 425                 430         


Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser 
        435                 440                 445             


Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala 
    450                 455                 460                 


Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro 
465                 470                 475                 480 


Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro 
                485                 490                 495     


Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr 
            500                 505                 510         


Val Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val 
        515                 520                 525             


Asn Phe Asn Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser 
    530                 535                 540                 


Asn Lys Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp 
545                 550                 555                 560 


Thr Thr Asp Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile 
                565                 570                 575     


Thr Pro Cys Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn 
            580                 585                 590         


Thr Ser Asn Gln Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu 
        595                 600                 605             


Val Pro Val Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val 
    610                 615                 620                 


Tyr Ser Thr Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile 
625                 630                 635                 640 


Gly Ala Glu His Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly 
                645                 650                 655     


Ala Gly Ile Cys Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro Gly Ser 
            660                 665                 670         


Ala Ser Ser Val Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu 
        675                 680                 685             


Gly Ala Glu Asn Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro 
    690                 695                 700                 


Thr Asn Phe Thr Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met 
705                 710                 715                 720 


Thr Lys Thr Ser Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr 
                725                 730                 735     


Glu Cys Ser Asn Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu 
            740                 745                 750         


Asn Arg Ala Leu Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln 
        755                 760                 765             


Glu Val Phe Ala Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys 
    770                 775                 780                 


Asp Phe Gly Gly Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys 
785                 790                 795                 800 


Pro Ser Lys Arg Ser Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr 
                805                 810                 815     


Leu Ala Asp Ala Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp 
            820                 825                 830         


Ile Ala Ala Arg Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr 
        835                 840                 845             


Val Leu Pro Pro Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser 
    850                 855                 860                 


Ala Leu Leu Ala Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly 
865                 870                 875                 880 


Ala Ala Leu Gln Ile Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn 
                885                 890                 895     


Gly Ile Gly Val Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile 
            900                 905                 910         


Ala Asn Gln Phe Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser 
        915                 920                 925             


Ser Thr Ala Ser Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn 
    930                 935                 940                 


Ala Gln Ala Leu Asn Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly 
945                 950                 955                 960 


Ala Ile Ser Ser Val Leu Asn Asp Ile Leu Ser Arg Leu Asp Pro Pro 
                965                 970                 975     


Glu Ala Glu Val Gln Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser 
            980                 985                 990         


Leu Gln Thr Tyr Val Thr Gln Gln  Leu Ile Arg Ala Ala  Glu Ile Arg 
        995                 1000                 1005             


Ala Ser  Ala Asn Leu Ala Ala  Thr Lys Met Ser Glu  Cys Val Leu 
    1010                 1015                 1020             


Gly Gln  Ser Lys Arg Val Asp  Phe Cys Gly Lys Gly  Tyr His Leu 
    1025                 1030                 1035             


Met Ser  Phe Pro Gln Ser Ala  Pro His Gly Val Val  Phe Leu His 
    1040                 1045                 1050             


Val Thr  Tyr Val Pro Ala Gln  Glu Lys Asn Phe Thr  Thr Ala Pro 
    1055                 1060                 1065             


Ala Ile  Cys His Asp Gly Lys  Ala His Phe Pro Arg  Glu Gly Val 
    1070                 1075                 1080             


Phe Val  Ser Asn Gly Thr His  Trp Phe Val Thr Gln  Arg Asn Phe 
    1085                 1090                 1095             


Tyr Glu  Pro Gln Ile Ile Thr  Thr Asp Asn Thr Phe  Val Ser Gly 
    1100                 1105                 1110             


Asn Cys  Asp Val Val Ile Gly  Ile Val Asn Asn Thr  Val Tyr Asp 
    1115                 1120                 1125             


Pro Leu  Gln Pro Glu Leu Asp  Ser Ile Lys Glu Glu  Leu Asp Lys 
    1130                 1135                 1140             


Ile His  Lys Asn Gly Ser Gly  Gly Ser Gly Asp Ile  Ile Lys Leu 
    1145                 1150                 1155             


Leu Asn  Glu Gln Val Asn Lys  Glu Met Gln Ser Ser  Asn Leu Tyr 
    1160                 1165                 1170             


Met Ser  Met Ser Ser Trp Cys  Tyr Thr His Ser Leu  Asp Gly Ala 
    1175                 1180                 1185             


Gly Leu  Phe Leu Phe Asp His  Ala Ala Glu Glu Tyr  Glu His Ala 
    1190                 1195                 1200             


Lys Lys  Leu Ile Ile Phe Leu  Asn Glu Asn Asn Val  Pro Val Gln 
    1205                 1210                 1215             


Leu Thr  Ser Ile Ser Ala Pro  Glu His Lys Phe Glu  Gly Leu Thr 
    1220                 1225                 1230             


Gln Ile  Phe Gln Lys Ala Tyr  Glu His Glu Gln His  Ile Ser Glu 
    1235                 1240                 1245             


Ser Ile  Asn Asn Ile Val Asp  His Ala Ile Lys Ser  Lys Asp His 
    1250                 1255                 1260             


Ala Thr  Phe Asn Phe Leu Gln  Trp Tyr Val Ala Glu  Gln His Glu 
    1265                 1270                 1275             


Glu Glu  Val Leu Phe Lys Asp  Ile Leu Asp Lys Ile  Glu Leu Ile 
    1280                 1285                 1290             


Gly Asn  Glu Asn His Gly Leu  Tyr Leu Ala Asp Gln  Tyr Val Lys 
    1295                 1300                 1305             


Gly Ile  Ala Lys Ser Arg Lys  Ser Gly Ser 
    1310                 1315             


<210> 153
<211> 1317
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 153
Ser Ser Gln Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala 
1               5                   10                  15      


Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe 
            20                  25                  30          


Arg Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe 
        35                  40                  45              


Ser Asn Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly 
    50                  55                  60                  


Thr Lys Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr 
65                  70                  75                  80  


Phe Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly 
                85                  90                  95      


Thr Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala 
            100                 105                 110         


Thr Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro 
        115                 120                 125             


Phe Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser 
    130                 135                 140                 


Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val 
145                 150                 155                 160 


Ser Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys 
                165                 170                 175     


Asn Leu Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile 
            180                 185                 190         


Tyr Ser Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly 
        195                 200                 205             


Phe Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile 
    210                 215                 220                 


Thr Arg Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro 
225                 230                 235                 240 


Gly Asp Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val 
                245                 250                 255     


Gly Tyr Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly 
            260                 265                 270         


Thr Ile Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr 
        275                 280                 285             


Lys Cys Thr Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr 
    290                 295                 300                 


Ser Asn Phe Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn 
305                 310                 315                 320 


Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe 
                325                 330                 335     


Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala 
            340                 345                 350         


Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys 
        355                 360                 365             


Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val 
    370                 375                 380                 


Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala 
385                 390                 395                 400 


Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp 
                405                 410                 415     


Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser 
            420                 425                 430         


Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser 
        435                 440                 445             


Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala 
    450                 455                 460                 


Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro 
465                 470                 475                 480 


Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro 
                485                 490                 495     


Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr 
            500                 505                 510         


Val Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val 
        515                 520                 525             


Asn Phe Asn Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser 
    530                 535                 540                 


Asn Lys Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp 
545                 550                 555                 560 


Thr Thr Asp Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile 
                565                 570                 575     


Thr Pro Cys Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn 
            580                 585                 590         


Thr Ser Asn Gln Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu 
        595                 600                 605             


Val Pro Val Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val 
    610                 615                 620                 


Tyr Ser Thr Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile 
625                 630                 635                 640 


Gly Ala Glu His Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly 
                645                 650                 655     


Ala Gly Ile Cys Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro Gly Ser 
            660                 665                 670         


Ala Ser Ser Val Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu 
        675                 680                 685             


Gly Ala Glu Asn Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro 
    690                 695                 700                 


Thr Asn Phe Thr Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met 
705                 710                 715                 720 


Thr Lys Thr Ser Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr 
                725                 730                 735     


Glu Cys Ser Asn Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu 
            740                 745                 750         


Asn Arg Ala Leu Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln 
        755                 760                 765             


Glu Val Phe Ala Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys 
    770                 775                 780                 


Asp Phe Gly Gly Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys 
785                 790                 795                 800 


Pro Ser Lys Arg Ser Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr 
                805                 810                 815     


Leu Ala Asp Ala Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp 
            820                 825                 830         


Ile Ala Ala Arg Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr 
        835                 840                 845             


Val Leu Pro Pro Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser 
    850                 855                 860                 


Ala Leu Leu Ala Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly 
865                 870                 875                 880 


Ala Ala Leu Gln Ile Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn 
                885                 890                 895     


Gly Ile Gly Val Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile 
            900                 905                 910         


Ala Asn Gln Phe Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser 
        915                 920                 925             


Ser Thr Ala Ser Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn 
    930                 935                 940                 


Ala Gln Ala Leu Asn Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly 
945                 950                 955                 960 


Ala Ile Ser Ser Val Leu Asn Asp Ile Leu Ser Arg Leu Asp Pro Pro 
                965                 970                 975     


Glu Ala Glu Val Gln Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser 
            980                 985                 990         


Leu Gln Thr Tyr Val Thr Gln Gln  Leu Ile Arg Ala Ala  Glu Ile Arg 
        995                 1000                 1005             


Ala Ser  Ala Asn Leu Ala Ala  Thr Lys Met Ser Glu  Cys Val Leu 
    1010                 1015                 1020             


Gly Gln  Ser Lys Arg Val Asp  Phe Cys Gly Lys Gly  Tyr His Leu 
    1025                 1030                 1035             


Met Ser  Phe Pro Gln Ser Ala  Pro His Gly Val Val  Phe Leu His 
    1040                 1045                 1050             


Val Thr  Tyr Val Pro Ala Gln  Glu Lys Asn Phe Thr  Thr Ala Pro 
    1055                 1060                 1065             


Ala Ile  Cys His Asp Gly Lys  Ala His Phe Pro Arg  Glu Gly Val 
    1070                 1075                 1080             


Phe Val  Ser Asn Gly Thr His  Trp Phe Val Thr Gln  Arg Asn Phe 
    1085                 1090                 1095             


Tyr Glu  Pro Gln Ile Ile Thr  Thr Asp Asn Thr Phe  Val Ser Gly 
    1100                 1105                 1110             


Asn Cys  Asp Val Val Ile Gly  Ile Val Asn Asn Thr  Val Tyr Asp 
    1115                 1120                 1125             


Pro Leu  Gln Pro Glu Leu Asp  Ser Phe Lys Glu Glu  Leu Asp Lys 
    1130                 1135                 1140             


Tyr Phe  Lys Gly Ser Gly Gly  Ser Gly Asp Ile Ile  Lys Leu Leu 
    1145                 1150                 1155             


Asn Glu  Gln Val Asn Lys Glu  Met Gln Ser Ser Asn  Leu Tyr Met 
    1160                 1165                 1170             


Ser Met  Ser Ser Trp Cys Tyr  Thr His Ser Leu Asp  Gly Ala Gly 
    1175                 1180                 1185             


Leu Phe  Leu Phe Asp His Ala  Ala Glu Glu Tyr Glu  His Ala Lys 
    1190                 1195                 1200             


Lys Leu  Ile Ile Phe Leu Asn  Glu Asn Asn Val Pro  Val Gln Leu 
    1205                 1210                 1215             


Thr Ser  Ile Ser Ala Pro Glu  His Lys Phe Glu Gly  Leu Thr Gln 
    1220                 1225                 1230             


Ile Phe  Gln Lys Ala Tyr Glu  His Glu Gln His Ile  Ser Glu Ser 
    1235                 1240                 1245             


Ile Asn  Asn Ile Val Asp His  Ala Ile Lys Ser Lys  Asp His Ala 
    1250                 1255                 1260             


Thr Phe  Asn Phe Leu Gln Trp  Tyr Val Ala Glu Gln  His Glu Glu 
    1265                 1270                 1275             


Glu Val  Leu Phe Lys Asp Ile  Leu Asp Lys Ile Glu  Leu Ile Gly 
    1280                 1285                 1290             


Asn Glu  Asn His Gly Leu Tyr  Leu Ala Asp Gln Tyr  Val Lys Gly 
    1295                 1300                 1305             


Ile Ala  Lys Ser Arg Lys Ser  Gly Ser 
    1310                 1315         


<210> 154
<211> 1319
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 154
Ser Ser Gln Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala 
1               5                   10                  15      


Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe 
            20                  25                  30          


Arg Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe 
        35                  40                  45              


Ser Asn Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly 
    50                  55                  60                  


Thr Lys Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr 
65                  70                  75                  80  


Phe Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly 
                85                  90                  95      


Thr Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala 
            100                 105                 110         


Thr Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro 
        115                 120                 125             


Phe Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser 
    130                 135                 140                 


Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val 
145                 150                 155                 160 


Ser Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys 
                165                 170                 175     


Asn Leu Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile 
            180                 185                 190         


Tyr Ser Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly 
        195                 200                 205             


Phe Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile 
    210                 215                 220                 


Thr Arg Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro 
225                 230                 235                 240 


Gly Asp Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val 
                245                 250                 255     


Gly Tyr Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly 
            260                 265                 270         


Thr Ile Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr 
        275                 280                 285             


Lys Cys Thr Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr 
    290                 295                 300                 


Ser Asn Phe Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn 
305                 310                 315                 320 


Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe 
                325                 330                 335     


Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala 
            340                 345                 350         


Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys 
        355                 360                 365             


Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val 
    370                 375                 380                 


Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala 
385                 390                 395                 400 


Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp 
                405                 410                 415     


Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser 
            420                 425                 430         


Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser 
        435                 440                 445             


Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala 
    450                 455                 460                 


Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro 
465                 470                 475                 480 


Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro 
                485                 490                 495     


Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr 
            500                 505                 510         


Val Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val 
        515                 520                 525             


Asn Phe Asn Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser 
    530                 535                 540                 


Asn Lys Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp 
545                 550                 555                 560 


Thr Thr Asp Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile 
                565                 570                 575     


Thr Pro Cys Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn 
            580                 585                 590         


Thr Ser Asn Gln Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu 
        595                 600                 605             


Val Pro Val Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val 
    610                 615                 620                 


Tyr Ser Thr Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile 
625                 630                 635                 640 


Gly Ala Glu His Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly 
                645                 650                 655     


Ala Gly Ile Cys Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro Gly Ser 
            660                 665                 670         


Ala Ser Ser Val Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu 
        675                 680                 685             


Gly Ala Glu Asn Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro 
    690                 695                 700                 


Thr Asn Phe Thr Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met 
705                 710                 715                 720 


Thr Lys Thr Ser Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr 
                725                 730                 735     


Glu Cys Ser Asn Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu 
            740                 745                 750         


Asn Arg Ala Leu Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln 
        755                 760                 765             


Glu Val Phe Ala Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys 
    770                 775                 780                 


Asp Phe Gly Gly Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys 
785                 790                 795                 800 


Pro Ser Lys Arg Ser Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr 
                805                 810                 815     


Leu Ala Asp Ala Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp 
            820                 825                 830         


Ile Ala Ala Arg Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr 
        835                 840                 845             


Val Leu Pro Pro Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser 
    850                 855                 860                 


Ala Leu Leu Ala Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly 
865                 870                 875                 880 


Ala Ala Leu Gln Ile Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn 
                885                 890                 895     


Gly Ile Gly Val Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile 
            900                 905                 910         


Ala Asn Gln Phe Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser 
        915                 920                 925             


Ser Thr Ala Ser Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn 
    930                 935                 940                 


Ala Gln Ala Leu Asn Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly 
945                 950                 955                 960 


Ala Ile Ser Ser Val Leu Asn Asp Ile Leu Ser Arg Leu Asp Pro Pro 
                965                 970                 975     


Glu Ala Glu Val Gln Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser 
            980                 985                 990         


Leu Gln Thr Tyr Val Thr Gln Gln  Leu Ile Arg Ala Ala  Glu Ile Arg 
        995                 1000                 1005             


Ala Ser  Ala Asn Leu Ala Ala  Thr Lys Met Ser Glu  Cys Val Leu 
    1010                 1015                 1020             


Gly Gln  Ser Lys Arg Val Asp  Phe Cys Gly Lys Gly  Tyr His Leu 
    1025                 1030                 1035             


Met Ser  Phe Pro Gln Ser Ala  Pro His Gly Val Val  Phe Leu His 
    1040                 1045                 1050             


Val Thr  Tyr Val Pro Ala Gln  Glu Lys Asn Phe Thr  Thr Ala Pro 
    1055                 1060                 1065             


Ala Ile  Cys His Asp Gly Lys  Ala His Phe Pro Arg  Glu Gly Val 
    1070                 1075                 1080             


Phe Val  Ser Asn Gly Thr His  Trp Phe Val Thr Gln  Arg Asn Phe 
    1085                 1090                 1095             


Tyr Glu  Pro Gln Ile Ile Thr  Thr Asp Asn Thr Phe  Val Ser Gly 
    1100                 1105                 1110             


Asn Cys  Asp Val Val Ile Gly  Ile Val Asn Asn Thr  Val Tyr Asp 
    1115                 1120                 1125             


Pro Leu  Gln Pro Glu Leu Asp  Ser Phe Lys Glu Glu  Leu Asp Lys 
    1130                 1135                 1140             


Tyr Phe  Lys Asn His Gly Ser  Gly Gly Ser Gly Asp  Ile Ile Lys 
    1145                 1150                 1155             


Leu Leu  Asn Glu Gln Val Asn  Lys Glu Met Gln Ser  Ser Asn Leu 
    1160                 1165                 1170             


Tyr Met  Ser Met Ser Ser Trp  Cys Tyr Thr His Ser  Leu Asp Gly 
    1175                 1180                 1185             


Ala Gly  Leu Phe Leu Phe Asp  His Ala Ala Glu Glu  Tyr Glu His 
    1190                 1195                 1200             


Ala Lys  Lys Leu Ile Ile Phe  Leu Asn Glu Asn Asn  Val Pro Val 
    1205                 1210                 1215             


Gln Leu  Thr Ser Ile Ser Ala  Pro Glu His Lys Phe  Glu Gly Leu 
    1220                 1225                 1230             


Thr Gln  Ile Phe Gln Lys Ala  Tyr Glu His Glu Gln  His Ile Ser 
    1235                 1240                 1245             


Glu Ser  Ile Asn Asn Ile Val  Asp His Ala Ile Lys  Ser Lys Asp 
    1250                 1255                 1260             


His Ala  Thr Phe Asn Phe Leu  Gln Trp Tyr Val Ala  Glu Gln His 
    1265                 1270                 1275             


Glu Glu  Glu Val Leu Phe Lys  Asp Ile Leu Asp Lys  Ile Glu Leu 
    1280                 1285                 1290             


Ile Gly  Asn Glu Asn His Gly  Leu Tyr Leu Ala Asp  Gln Tyr Val 
    1295                 1300                 1305             


Lys Gly  Ile Ala Lys Ser Arg  Lys Ser Gly Ser 
    1310                 1315                 


<210> 155
<211> 1320
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 155
Ser Ser Gln Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala 
1               5                   10                  15      


Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe 
            20                  25                  30          


Arg Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe 
        35                  40                  45              


Ser Asn Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly 
    50                  55                  60                  


Thr Lys Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr 
65                  70                  75                  80  


Phe Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly 
                85                  90                  95      


Thr Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala 
            100                 105                 110         


Thr Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro 
        115                 120                 125             


Phe Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser 
    130                 135                 140                 


Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val 
145                 150                 155                 160 


Ser Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys 
                165                 170                 175     


Asn Leu Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile 
            180                 185                 190         


Tyr Ser Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly 
        195                 200                 205             


Phe Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile 
    210                 215                 220                 


Thr Arg Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro 
225                 230                 235                 240 


Gly Asp Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val 
                245                 250                 255     


Gly Tyr Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly 
            260                 265                 270         


Thr Ile Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr 
        275                 280                 285             


Lys Cys Thr Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr 
    290                 295                 300                 


Ser Asn Phe Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn 
305                 310                 315                 320 


Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe 
                325                 330                 335     


Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala 
            340                 345                 350         


Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys 
        355                 360                 365             


Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val 
    370                 375                 380                 


Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala 
385                 390                 395                 400 


Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp 
                405                 410                 415     


Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser 
            420                 425                 430         


Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser 
        435                 440                 445             


Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala 
    450                 455                 460                 


Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro 
465                 470                 475                 480 


Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro 
                485                 490                 495     


Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr 
            500                 505                 510         


Val Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val 
        515                 520                 525             


Asn Phe Asn Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser 
    530                 535                 540                 


Asn Lys Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp 
545                 550                 555                 560 


Thr Thr Asp Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile 
                565                 570                 575     


Thr Pro Cys Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn 
            580                 585                 590         


Thr Ser Asn Gln Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu 
        595                 600                 605             


Val Pro Val Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val 
    610                 615                 620                 


Tyr Ser Thr Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile 
625                 630                 635                 640 


Gly Ala Glu His Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly 
                645                 650                 655     


Ala Gly Ile Cys Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro Gly Ser 
            660                 665                 670         


Ala Ser Ser Val Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu 
        675                 680                 685             


Gly Ala Glu Asn Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro 
    690                 695                 700                 


Thr Asn Phe Thr Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met 
705                 710                 715                 720 


Thr Lys Thr Ser Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr 
                725                 730                 735     


Glu Cys Ser Asn Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu 
            740                 745                 750         


Asn Arg Ala Leu Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln 
        755                 760                 765             


Glu Val Phe Ala Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys 
    770                 775                 780                 


Asp Phe Gly Gly Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys 
785                 790                 795                 800 


Pro Ser Lys Arg Ser Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr 
                805                 810                 815     


Leu Ala Asp Ala Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp 
            820                 825                 830         


Ile Ala Ala Arg Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr 
        835                 840                 845             


Val Leu Pro Pro Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser 
    850                 855                 860                 


Ala Leu Leu Ala Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly 
865                 870                 875                 880 


Ala Ala Leu Gln Ile Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn 
                885                 890                 895     


Gly Ile Gly Val Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile 
            900                 905                 910         


Ala Asn Gln Phe Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser 
        915                 920                 925             


Ser Thr Ala Ser Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn 
    930                 935                 940                 


Ala Gln Ala Leu Asn Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly 
945                 950                 955                 960 


Ala Ile Ser Ser Val Leu Asn Asp Ile Leu Ser Arg Leu Asp Pro Pro 
                965                 970                 975     


Glu Ala Glu Val Gln Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser 
            980                 985                 990         


Leu Gln Thr Tyr Val Thr Gln Gln  Leu Ile Arg Ala Ala  Glu Ile Arg 
        995                 1000                 1005             


Ala Ser  Ala Asn Leu Ala Ala  Thr Lys Met Ser Glu  Cys Val Leu 
    1010                 1015                 1020             


Gly Gln  Ser Lys Arg Val Asp  Phe Cys Gly Lys Gly  Tyr His Leu 
    1025                 1030                 1035             


Met Ser  Phe Pro Gln Ser Ala  Pro His Gly Val Val  Phe Leu His 
    1040                 1045                 1050             


Val Thr  Tyr Val Pro Ala Gln  Glu Lys Asn Phe Thr  Thr Ala Pro 
    1055                 1060                 1065             


Ala Ile  Cys His Asp Gly Lys  Ala His Phe Pro Arg  Glu Gly Val 
    1070                 1075                 1080             


Phe Val  Ser Asn Gly Thr His  Trp Phe Val Thr Gln  Arg Asn Phe 
    1085                 1090                 1095             


Tyr Glu  Pro Gln Ile Ile Thr  Thr Asp Asn Thr Phe  Val Ser Gly 
    1100                 1105                 1110             


Asn Cys  Asp Val Val Ile Gly  Ile Val Asn Asn Thr  Val Tyr Asp 
    1115                 1120                 1125             


Pro Leu  Gln Pro Glu Leu Asp  Ser Phe Lys Glu Glu  Leu Asp Lys 
    1130                 1135                 1140             


Tyr Phe  Lys Asn His Thr Gly  Ser Gly Gly Ser Gly  Asp Ile Ile 
    1145                 1150                 1155             


Lys Leu  Leu Asn Glu Gln Val  Asn Lys Glu Met Gln  Ser Ser Asn 
    1160                 1165                 1170             


Leu Tyr  Met Ser Met Ser Ser  Trp Cys Tyr Thr His  Ser Leu Asp 
    1175                 1180                 1185             


Gly Ala  Gly Leu Phe Leu Phe  Asp His Ala Ala Glu  Glu Tyr Glu 
    1190                 1195                 1200             


His Ala  Lys Lys Leu Ile Ile  Phe Leu Asn Glu Asn  Asn Val Pro 
    1205                 1210                 1215             


Val Gln  Leu Thr Ser Ile Ser  Ala Pro Glu His Lys  Phe Glu Gly 
    1220                 1225                 1230             


Leu Thr  Gln Ile Phe Gln Lys  Ala Tyr Glu His Glu  Gln His Ile 
    1235                 1240                 1245             


Ser Glu  Ser Ile Asn Asn Ile  Val Asp His Ala Ile  Lys Ser Lys 
    1250                 1255                 1260             


Asp His  Ala Thr Phe Asn Phe  Leu Gln Trp Tyr Val  Ala Glu Gln 
    1265                 1270                 1275             


His Glu  Glu Glu Val Leu Phe  Lys Asp Ile Leu Asp  Lys Ile Glu 
    1280                 1285                 1290             


Leu Ile  Gly Asn Glu Asn His  Gly Leu Tyr Leu Ala  Asp Gln Tyr 
    1295                 1300                 1305             


Val Lys  Gly Ile Ala Lys Ser  Arg Lys Ser Gly Ser  
    1310                 1315                 1320 


<210> 156
<211> 1317
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 156
Ser Ser Gln Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala 
1               5                   10                  15      


Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe 
            20                  25                  30          


Arg Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe 
        35                  40                  45              


Ser Asn Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly 
    50                  55                  60                  


Thr Lys Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr 
65                  70                  75                  80  


Phe Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly 
                85                  90                  95      


Thr Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala 
            100                 105                 110         


Thr Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro 
        115                 120                 125             


Phe Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser 
    130                 135                 140                 


Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val 
145                 150                 155                 160 


Ser Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys 
                165                 170                 175     


Asn Leu Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile 
            180                 185                 190         


Tyr Ser Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly 
        195                 200                 205             


Phe Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile 
    210                 215                 220                 


Thr Arg Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro 
225                 230                 235                 240 


Gly Asp Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val 
                245                 250                 255     


Gly Tyr Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly 
            260                 265                 270         


Thr Ile Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr 
        275                 280                 285             


Lys Cys Thr Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr 
    290                 295                 300                 


Ser Asn Phe Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn 
305                 310                 315                 320 


Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe 
                325                 330                 335     


Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala 
            340                 345                 350         


Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys 
        355                 360                 365             


Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val 
    370                 375                 380                 


Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala 
385                 390                 395                 400 


Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp 
                405                 410                 415     


Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser 
            420                 425                 430         


Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser 
        435                 440                 445             


Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala 
    450                 455                 460                 


Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro 
465                 470                 475                 480 


Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro 
                485                 490                 495     


Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr 
            500                 505                 510         


Val Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val 
        515                 520                 525             


Asn Phe Asn Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser 
    530                 535                 540                 


Asn Lys Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp 
545                 550                 555                 560 


Thr Thr Asp Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile 
                565                 570                 575     


Thr Pro Cys Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn 
            580                 585                 590         


Thr Ser Asn Gln Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu 
        595                 600                 605             


Val Pro Val Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val 
    610                 615                 620                 


Tyr Ser Thr Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile 
625                 630                 635                 640 


Gly Ala Glu His Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly 
                645                 650                 655     


Ala Gly Ile Cys Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro Gly Ser 
            660                 665                 670         


Ala Ser Ser Val Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu 
        675                 680                 685             


Gly Ala Glu Asn Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro 
    690                 695                 700                 


Thr Asn Phe Thr Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met 
705                 710                 715                 720 


Thr Lys Thr Ser Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr 
                725                 730                 735     


Glu Cys Ser Asn Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu 
            740                 745                 750         


Asn Arg Ala Leu Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln 
        755                 760                 765             


Glu Val Phe Ala Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys 
    770                 775                 780                 


Asp Phe Gly Gly Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys 
785                 790                 795                 800 


Pro Ser Lys Arg Ser Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr 
                805                 810                 815     


Leu Ala Asp Ala Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp 
            820                 825                 830         


Ile Ala Ala Arg Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr 
        835                 840                 845             


Val Leu Pro Pro Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser 
    850                 855                 860                 


Ala Leu Leu Ala Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly 
865                 870                 875                 880 


Ala Ala Leu Gln Ile Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn 
                885                 890                 895     


Gly Ile Gly Val Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile 
            900                 905                 910         


Ala Asn Gln Phe Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser 
        915                 920                 925             


Ser Thr Ala Ser Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn 
    930                 935                 940                 


Ala Gln Ala Leu Asn Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly 
945                 950                 955                 960 


Ala Ile Ser Ser Val Leu Asn Asp Ile Leu Ser Arg Leu Asp Pro Pro 
                965                 970                 975     


Glu Ala Glu Val Gln Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser 
            980                 985                 990         


Leu Gln Thr Tyr Val Thr Gln Gln  Leu Ile Arg Ala Ala  Glu Ile Arg 
        995                 1000                 1005             


Ala Ser  Ala Asn Leu Ala Ala  Thr Lys Met Ser Glu  Cys Val Leu 
    1010                 1015                 1020             


Gly Gln  Ser Lys Arg Val Asp  Phe Cys Gly Lys Gly  Tyr His Leu 
    1025                 1030                 1035             


Met Ser  Phe Pro Gln Ser Ala  Pro His Gly Val Val  Phe Leu His 
    1040                 1045                 1050             


Val Thr  Tyr Val Pro Ala Gln  Glu Lys Asn Phe Thr  Thr Ala Pro 
    1055                 1060                 1065             


Ala Ile  Cys His Asp Gly Lys  Ala His Phe Pro Arg  Glu Gly Val 
    1070                 1075                 1080             


Phe Val  Ser Asn Gly Thr His  Trp Phe Val Thr Gln  Arg Asn Phe 
    1085                 1090                 1095             


Tyr Glu  Pro Gln Ile Ile Thr  Thr Asp Asn Thr Phe  Val Ser Gly 
    1100                 1105                 1110             


Asn Cys  Asp Val Val Ile Gly  Ile Val Asn Asn Thr  Val Tyr Asp 
    1115                 1120                 1125             


Pro Leu  Gln Pro Glu Leu Asp  Ser Ile Lys Glu Glu  Leu Asp Lys 
    1130                 1135                 1140             


Ile His  Lys Gly Ser Gly Gly  Ser Gly Asp Ile Ile  Lys Leu Leu 
    1145                 1150                 1155             


Asn Glu  Gln Val Asn Lys Glu  Met Gln Ser Ser Asn  Leu Tyr Met 
    1160                 1165                 1170             


Ser Met  Ser Ser Trp Cys Tyr  Thr His Ser Leu Asp  Gly Ala Gly 
    1175                 1180                 1185             


Leu Phe  Leu Phe Asp His Ala  Ala Glu Glu Tyr Glu  His Ala Lys 
    1190                 1195                 1200             


Lys Leu  Ile Ile Phe Leu Asn  Glu Asn Asn Val Pro  Val Gln Leu 
    1205                 1210                 1215             


Thr Ser  Ile Ser Ala Pro Glu  His Lys Phe Glu Gly  Leu Thr Gln 
    1220                 1225                 1230             


Ile Phe  Gln Lys Ala Tyr Glu  His Glu Gln His Ile  Ser Glu Ser 
    1235                 1240                 1245             


Ile Asn  Asn Ile Val Asp His  Ala Ile Lys Ser Lys  Asp His Ala 
    1250                 1255                 1260             


Thr Phe  Asn Phe Leu Gln Trp  Tyr Val Ala Glu Gln  His Glu Glu 
    1265                 1270                 1275             


Glu Val  Leu Phe Lys Asp Ile  Leu Asp Lys Ile Glu  Leu Ile Gly 
    1280                 1285                 1290             


Asn Glu  Asn His Gly Leu Tyr  Leu Ala Asp Gln Tyr  Val Lys Gly 
    1295                 1300                 1305             


Ile Ala  Lys Ser Arg Lys Ser  Gly Ser 
    1310                 1315         


<210> 157
<211> 1319
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 157
Ser Ser Gln Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala 
1               5                   10                  15      


Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe 
            20                  25                  30          


Arg Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe 
        35                  40                  45              


Ser Asn Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly 
    50                  55                  60                  


Thr Lys Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr 
65                  70                  75                  80  


Phe Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly 
                85                  90                  95      


Thr Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala 
            100                 105                 110         


Thr Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro 
        115                 120                 125             


Phe Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser 
    130                 135                 140                 


Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val 
145                 150                 155                 160 


Ser Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys 
                165                 170                 175     


Asn Leu Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile 
            180                 185                 190         


Tyr Ser Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly 
        195                 200                 205             


Phe Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile 
    210                 215                 220                 


Thr Arg Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro 
225                 230                 235                 240 


Gly Asp Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val 
                245                 250                 255     


Gly Tyr Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly 
            260                 265                 270         


Thr Ile Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr 
        275                 280                 285             


Lys Cys Thr Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr 
    290                 295                 300                 


Ser Asn Phe Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn 
305                 310                 315                 320 


Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe 
                325                 330                 335     


Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala 
            340                 345                 350         


Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys 
        355                 360                 365             


Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val 
    370                 375                 380                 


Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala 
385                 390                 395                 400 


Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp 
                405                 410                 415     


Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser 
            420                 425                 430         


Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser 
        435                 440                 445             


Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala 
    450                 455                 460                 


Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro 
465                 470                 475                 480 


Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro 
                485                 490                 495     


Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr 
            500                 505                 510         


Val Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val 
        515                 520                 525             


Asn Phe Asn Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser 
    530                 535                 540                 


Asn Lys Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp 
545                 550                 555                 560 


Thr Thr Asp Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile 
                565                 570                 575     


Thr Pro Cys Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn 
            580                 585                 590         


Thr Ser Asn Gln Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu 
        595                 600                 605             


Val Pro Val Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val 
    610                 615                 620                 


Tyr Ser Thr Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile 
625                 630                 635                 640 


Gly Ala Glu His Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly 
                645                 650                 655     


Ala Gly Ile Cys Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro Gly Ser 
            660                 665                 670         


Ala Ser Ser Val Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu 
        675                 680                 685             


Gly Ala Glu Asn Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro 
    690                 695                 700                 


Thr Asn Phe Thr Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met 
705                 710                 715                 720 


Thr Lys Thr Ser Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr 
                725                 730                 735     


Glu Cys Ser Asn Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu 
            740                 745                 750         


Asn Arg Ala Leu Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln 
        755                 760                 765             


Glu Val Phe Ala Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys 
    770                 775                 780                 


Asp Phe Gly Gly Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys 
785                 790                 795                 800 


Pro Ser Lys Arg Ser Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr 
                805                 810                 815     


Leu Ala Asp Ala Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp 
            820                 825                 830         


Ile Ala Ala Arg Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr 
        835                 840                 845             


Val Leu Pro Pro Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser 
    850                 855                 860                 


Ala Leu Leu Ala Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly 
865                 870                 875                 880 


Ala Ala Leu Gln Ile Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn 
                885                 890                 895     


Gly Ile Gly Val Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile 
            900                 905                 910         


Ala Asn Gln Phe Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser 
        915                 920                 925             


Ser Thr Ala Ser Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn 
    930                 935                 940                 


Ala Gln Ala Leu Asn Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly 
945                 950                 955                 960 


Ala Ile Ser Ser Val Leu Asn Asp Ile Leu Ser Arg Leu Asp Pro Pro 
                965                 970                 975     


Glu Ala Glu Val Gln Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser 
            980                 985                 990         


Leu Gln Thr Tyr Val Thr Gln Gln  Leu Ile Arg Ala Ala  Glu Ile Arg 
        995                 1000                 1005             


Ala Ser  Ala Asn Leu Ala Ala  Thr Lys Met Ser Glu  Cys Val Leu 
    1010                 1015                 1020             


Gly Gln  Ser Lys Arg Val Asp  Phe Cys Gly Lys Gly  Tyr His Leu 
    1025                 1030                 1035             


Met Ser  Phe Pro Gln Ser Ala  Pro His Gly Val Val  Phe Leu His 
    1040                 1045                 1050             


Val Thr  Tyr Val Pro Ala Gln  Glu Lys Asn Phe Thr  Thr Ala Pro 
    1055                 1060                 1065             


Ala Ile  Cys His Asp Gly Lys  Ala His Phe Pro Arg  Glu Gly Val 
    1070                 1075                 1080             


Phe Val  Ser Asn Gly Thr His  Trp Phe Val Thr Gln  Arg Asn Phe 
    1085                 1090                 1095             


Tyr Glu  Pro Gln Ile Ile Thr  Thr Asp Asn Thr Phe  Val Ser Gly 
    1100                 1105                 1110             


Asn Cys  Asp Val Val Ile Gly  Ile Val Asn Asn Thr  Val Tyr Asp 
    1115                 1120                 1125             


Pro Leu  Gln Pro Glu Leu Asp  Ser Ile Lys Glu Glu  Leu Asp Lys 
    1130                 1135                 1140             


Ile His  Lys Asn His Gly Ser  Gly Gly Ser Gly Asp  Ile Ile Lys 
    1145                 1150                 1155             


Leu Leu  Asn Glu Gln Val Asn  Lys Glu Met Gln Ser  Ser Asn Leu 
    1160                 1165                 1170             


Tyr Met  Ser Met Ser Ser Trp  Cys Tyr Thr His Ser  Leu Asp Gly 
    1175                 1180                 1185             


Ala Gly  Leu Phe Leu Phe Asp  His Ala Ala Glu Glu  Tyr Glu His 
    1190                 1195                 1200             


Ala Lys  Lys Leu Ile Ile Phe  Leu Asn Glu Asn Asn  Val Pro Val 
    1205                 1210                 1215             


Gln Leu  Thr Ser Ile Ser Ala  Pro Glu His Lys Phe  Glu Gly Leu 
    1220                 1225                 1230             


Thr Gln  Ile Phe Gln Lys Ala  Tyr Glu His Glu Gln  His Ile Ser 
    1235                 1240                 1245             


Glu Ser  Ile Asn Asn Ile Val  Asp His Ala Ile Lys  Ser Lys Asp 
    1250                 1255                 1260             


His Ala  Thr Phe Asn Phe Leu  Gln Trp Tyr Val Ala  Glu Gln His 
    1265                 1270                 1275             


Glu Glu  Glu Val Leu Phe Lys  Asp Ile Leu Asp Lys  Ile Glu Leu 
    1280                 1285                 1290             


Ile Gly  Asn Glu Asn His Gly  Leu Tyr Leu Ala Asp  Gln Tyr Val 
    1295                 1300                 1305             


Lys Gly  Ile Ala Lys Ser Arg  Lys Ser Gly Ser 
    1310                 1315                 


<210> 158
<211> 1320
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 158
Ser Ser Gln Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala 
1               5                   10                  15      


Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe 
            20                  25                  30          


Arg Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe 
        35                  40                  45              


Ser Asn Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly 
    50                  55                  60                  


Thr Lys Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr 
65                  70                  75                  80  


Phe Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly 
                85                  90                  95      


Thr Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala 
            100                 105                 110         


Thr Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro 
        115                 120                 125             


Phe Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser 
    130                 135                 140                 


Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val 
145                 150                 155                 160 


Ser Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys 
                165                 170                 175     


Asn Leu Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile 
            180                 185                 190         


Tyr Ser Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly 
        195                 200                 205             


Phe Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile 
    210                 215                 220                 


Thr Arg Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro 
225                 230                 235                 240 


Gly Asp Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val 
                245                 250                 255     


Gly Tyr Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly 
            260                 265                 270         


Thr Ile Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr 
        275                 280                 285             


Lys Cys Thr Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr 
    290                 295                 300                 


Ser Asn Phe Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn 
305                 310                 315                 320 


Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe 
                325                 330                 335     


Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala 
            340                 345                 350         


Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys 
        355                 360                 365             


Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val 
    370                 375                 380                 


Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala 
385                 390                 395                 400 


Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp 
                405                 410                 415     


Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser 
            420                 425                 430         


Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser 
        435                 440                 445             


Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala 
    450                 455                 460                 


Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro 
465                 470                 475                 480 


Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro 
                485                 490                 495     


Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr 
            500                 505                 510         


Val Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val 
        515                 520                 525             


Asn Phe Asn Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser 
    530                 535                 540                 


Asn Lys Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp 
545                 550                 555                 560 


Thr Thr Asp Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile 
                565                 570                 575     


Thr Pro Cys Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn 
            580                 585                 590         


Thr Ser Asn Gln Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu 
        595                 600                 605             


Val Pro Val Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val 
    610                 615                 620                 


Tyr Ser Thr Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile 
625                 630                 635                 640 


Gly Ala Glu His Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly 
                645                 650                 655     


Ala Gly Ile Cys Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro Gly Ser 
            660                 665                 670         


Ala Ser Ser Val Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu 
        675                 680                 685             


Gly Ala Glu Asn Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro 
    690                 695                 700                 


Thr Asn Phe Thr Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met 
705                 710                 715                 720 


Thr Lys Thr Ser Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr 
                725                 730                 735     


Glu Cys Ser Asn Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu 
            740                 745                 750         


Asn Arg Ala Leu Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln 
        755                 760                 765             


Glu Val Phe Ala Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys 
    770                 775                 780                 


Asp Phe Gly Gly Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys 
785                 790                 795                 800 


Pro Ser Lys Arg Ser Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr 
                805                 810                 815     


Leu Ala Asp Ala Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp 
            820                 825                 830         


Ile Ala Ala Arg Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr 
        835                 840                 845             


Val Leu Pro Pro Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser 
    850                 855                 860                 


Ala Leu Leu Ala Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly 
865                 870                 875                 880 


Ala Ala Leu Gln Ile Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn 
                885                 890                 895     


Gly Ile Gly Val Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile 
            900                 905                 910         


Ala Asn Gln Phe Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser 
        915                 920                 925             


Ser Thr Ala Ser Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn 
    930                 935                 940                 


Ala Gln Ala Leu Asn Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly 
945                 950                 955                 960 


Ala Ile Ser Ser Val Leu Asn Asp Ile Leu Ser Arg Leu Asp Pro Pro 
                965                 970                 975     


Glu Ala Glu Val Gln Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser 
            980                 985                 990         


Leu Gln Thr Tyr Val Thr Gln Gln  Leu Ile Arg Ala Ala  Glu Ile Arg 
        995                 1000                 1005             


Ala Ser  Ala Asn Leu Ala Ala  Thr Lys Met Ser Glu  Cys Val Leu 
    1010                 1015                 1020             


Gly Gln  Ser Lys Arg Val Asp  Phe Cys Gly Lys Gly  Tyr His Leu 
    1025                 1030                 1035             


Met Ser  Phe Pro Gln Ser Ala  Pro His Gly Val Val  Phe Leu His 
    1040                 1045                 1050             


Val Thr  Tyr Val Pro Ala Gln  Glu Lys Asn Phe Thr  Thr Ala Pro 
    1055                 1060                 1065             


Ala Ile  Cys His Asp Gly Lys  Ala His Phe Pro Arg  Glu Gly Val 
    1070                 1075                 1080             


Phe Val  Ser Asn Gly Thr His  Trp Phe Val Thr Gln  Arg Asn Phe 
    1085                 1090                 1095             


Tyr Glu  Pro Gln Ile Ile Thr  Thr Asp Asn Thr Phe  Val Ser Gly 
    1100                 1105                 1110             


Asn Cys  Asp Val Val Ile Gly  Ile Val Asn Asn Thr  Val Tyr Asp 
    1115                 1120                 1125             


Pro Leu  Gln Pro Glu Leu Asp  Ser Ile Lys Glu Glu  Leu Asp Lys 
    1130                 1135                 1140             


Ile His  Lys Asn His Thr Gly  Ser Gly Gly Ser Gly  Asp Ile Ile 
    1145                 1150                 1155             


Lys Leu  Leu Asn Glu Gln Val  Asn Lys Glu Met Gln  Ser Ser Asn 
    1160                 1165                 1170             


Leu Tyr  Met Ser Met Ser Ser  Trp Cys Tyr Thr His  Ser Leu Asp 
    1175                 1180                 1185             


Gly Ala  Gly Leu Phe Leu Phe  Asp His Ala Ala Glu  Glu Tyr Glu 
    1190                 1195                 1200             


His Ala  Lys Lys Leu Ile Ile  Phe Leu Asn Glu Asn  Asn Val Pro 
    1205                 1210                 1215             


Val Gln  Leu Thr Ser Ile Ser  Ala Pro Glu His Lys  Phe Glu Gly 
    1220                 1225                 1230             


Leu Thr  Gln Ile Phe Gln Lys  Ala Tyr Glu His Glu  Gln His Ile 
    1235                 1240                 1245             


Ser Glu  Ser Ile Asn Asn Ile  Val Asp His Ala Ile  Lys Ser Lys 
    1250                 1255                 1260             


Asp His  Ala Thr Phe Asn Phe  Leu Gln Trp Tyr Val  Ala Glu Gln 
    1265                 1270                 1275             


His Glu  Glu Glu Val Leu Phe  Lys Asp Ile Leu Asp  Lys Ile Glu 
    1280                 1285                 1290             


Leu Ile  Gly Asn Glu Asn His  Gly Leu Tyr Leu Ala  Asp Gln Tyr 
    1295                 1300                 1305             


Val Lys  Gly Ile Ala Lys Ser  Arg Lys Ser Gly Ser  
    1310                 1315                 1320 


<210> 159
<211> 1310
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 159
Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser 
1               5                   10                  15      


Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val 
            20                  25                  30          


Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr 
        35                  40                  45              


Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe 
    50                  55                  60                  


Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr 
65                  70                  75                  80  


Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp 
                85                  90                  95      


Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val 
            100                 105                 110         


Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val 
        115                 120                 125             


Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val 
    130                 135                 140                 


Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe 
145                 150                 155                 160 


Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu 
                165                 170                 175     


Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His 
            180                 185                 190         


Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu 
        195                 200                 205             


Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln 
    210                 215                 220                 


Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser 
225                 230                 235                 240 


Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln 
                245                 250                 255     


Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp 
            260                 265                 270         


Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu 
        275                 280                 285             


Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg 
    290                 295                 300                 


Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu 
305                 310                 315                 320 


Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr 
                325                 330                 335     


Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val 
            340                 345                 350         


Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser 
        355                 360                 365             


Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser 
    370                 375                 380                 


Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr 
385                 390                 395                 400 


Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly 
                405                 410                 415     


Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly 
            420                 425                 430         


Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro 
        435                 440                 445             


Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro 
    450                 455                 460                 


Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr 
465                 470                 475                 480 


Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val 
                485                 490                 495     


Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro 
            500                 505                 510         


Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe 
        515                 520                 525             


Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe 
    530                 535                 540                 


Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala 
545                 550                 555                 560 


Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser 
                565                 570                 575     


Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln 
            580                 585                 590         


Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala 
        595                 600                 605             


Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly 
    610                 615                 620                 


Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His 
625                 630                 635                 640 


Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys 
                645                 650                 655     


Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro Gly Ser Ala Ser Ser Val 
            660                 665                 670         


Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn 
        675                 680                 685             


Ser Val Ala Tyr Ser Asn Asn Thr Ile Ala Ile Pro Thr Asn Phe Thr 
    690                 695                 700                 


Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser 
705                 710                 715                 720 


Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn 
                725                 730                 735     


Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu 
            740                 745                 750         


Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala 
        755                 760                 765             


Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly 
    770                 775                 780                 


Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg 
785                 790                 795                 800 


Ser Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala 
                805                 810                 815     


Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg 
            820                 825                 830         


Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro 
        835                 840                 845             


Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala 
    850                 855                 860                 


Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln 
865                 870                 875                 880 


Ile Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val 
                885                 890                 895     


Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe 
            900                 905                 910         


Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser 
        915                 920                 925             


Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu 
    930                 935                 940                 


Asn Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser 
945                 950                 955                 960 


Val Leu Asn Asp Ile Leu Ser Arg Leu Asp Pro Pro Glu Ala Glu Val 
                965                 970                 975     


Gln Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser Leu Gln Thr Tyr 
            980                 985                 990         


Val Thr Gln Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
        995                 1000                 1005             


Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1010                 1015                 1020             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1025                 1030                 1035             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1040                 1045                 1050             


Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1055                 1060                 1065             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1070                 1075                 1080             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1085                 1090                 1095             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1100                 1105                 1110             


Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro 
    1115                 1120                 1125             


Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Gly  Ser Gly Gly 
    1130                 1135                 1140             


Ser Gly  Asp Ile Ile Lys Leu  Leu Asn Glu Gln Val  Asn Lys Glu 
    1145                 1150                 1155             


Met Gln  Ser Ser Asn Leu Tyr  Met Ser Met Ser Ser  Trp Cys Tyr 
    1160                 1165                 1170             


Thr His  Ser Leu Asp Gly Ala  Gly Leu Phe Leu Phe  Asp His Ala 
    1175                 1180                 1185             


Ala Glu  Glu Tyr Glu His Ala  Lys Lys Leu Ile Ile  Phe Leu Asn 
    1190                 1195                 1200             


Glu Asn  Asn Val Pro Val Gln  Leu Thr Ser Ile Ser  Ala Pro Glu 
    1205                 1210                 1215             


His Lys  Phe Glu Gly Leu Thr  Gln Ile Phe Gln Lys  Ala Tyr Glu 
    1220                 1225                 1230             


His Glu  Gln His Ile Ser Glu  Ser Ile Asn Asn Ile  Val Asp His 
    1235                 1240                 1245             


Ala Ile  Lys Ser Lys Asp His  Ala Thr Phe Asn Phe  Leu Gln Trp 
    1250                 1255                 1260             


Tyr Val  Ala Glu Gln His Glu  Glu Glu Val Leu Phe  Lys Asp Ile 
    1265                 1270                 1275             


Leu Asp  Lys Ile Glu Leu Ile  Gly Asn Glu Asn His  Gly Leu Tyr 
    1280                 1285                 1290             


Leu Ala  Asp Gln Tyr Val Lys  Gly Ile Ala Lys Ser  Arg Lys Ser 
    1295                 1300                 1305             


Gly Ser  
    1310 


<210> 160
<211> 1318
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 160
Ser Ser Gln Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala 
1               5                   10                  15      


Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe 
            20                  25                  30          


Arg Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe 
        35                  40                  45              


Ser Asn Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly 
    50                  55                  60                  


Thr Lys Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr 
65                  70                  75                  80  


Phe Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly 
                85                  90                  95      


Thr Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala 
            100                 105                 110         


Thr Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro 
        115                 120                 125             


Phe Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser 
    130                 135                 140                 


Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val 
145                 150                 155                 160 


Ser Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys 
                165                 170                 175     


Asn Leu Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile 
            180                 185                 190         


Tyr Ser Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly 
        195                 200                 205             


Phe Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile 
    210                 215                 220                 


Thr Arg Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro 
225                 230                 235                 240 


Gly Asp Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val 
                245                 250                 255     


Gly Tyr Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly 
            260                 265                 270         


Thr Ile Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr 
        275                 280                 285             


Lys Cys Thr Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr 
    290                 295                 300                 


Ser Asn Phe Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn 
305                 310                 315                 320 


Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe 
                325                 330                 335     


Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala 
            340                 345                 350         


Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys 
        355                 360                 365             


Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val 
    370                 375                 380                 


Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala 
385                 390                 395                 400 


Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp 
                405                 410                 415     


Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser 
            420                 425                 430         


Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser 
        435                 440                 445             


Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala 
    450                 455                 460                 


Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro 
465                 470                 475                 480 


Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro 
                485                 490                 495     


Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr 
            500                 505                 510         


Val Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val 
        515                 520                 525             


Asn Phe Asn Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser 
    530                 535                 540                 


Asn Lys Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp 
545                 550                 555                 560 


Thr Thr Asp Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile 
                565                 570                 575     


Thr Pro Cys Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn 
            580                 585                 590         


Thr Ser Asn Gln Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu 
        595                 600                 605             


Val Pro Val Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val 
    610                 615                 620                 


Tyr Ser Thr Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile 
625                 630                 635                 640 


Gly Ala Glu His Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly 
                645                 650                 655     


Ala Gly Ile Cys Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro Gly Ser 
            660                 665                 670         


Ala Ser Ser Val Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu 
        675                 680                 685             


Gly Ala Glu Asn Ser Val Ala Tyr Ser Asn Asn Thr Ile Ala Ile Pro 
    690                 695                 700                 


Thr Asn Phe Thr Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met 
705                 710                 715                 720 


Thr Lys Thr Ser Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr 
                725                 730                 735     


Glu Cys Ser Asn Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu 
            740                 745                 750         


Asn Arg Ala Leu Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln 
        755                 760                 765             


Glu Val Phe Ala Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys 
    770                 775                 780                 


Asp Phe Gly Gly Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys 
785                 790                 795                 800 


Pro Ser Lys Arg Ser Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr 
                805                 810                 815     


Leu Ala Asp Ala Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp 
            820                 825                 830         


Ile Ala Ala Arg Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr 
        835                 840                 845             


Val Leu Pro Pro Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser 
    850                 855                 860                 


Ala Leu Leu Ala Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly 
865                 870                 875                 880 


Ala Ala Leu Gln Ile Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn 
                885                 890                 895     


Gly Ile Gly Val Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile 
            900                 905                 910         


Ala Asn Gln Phe Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser 
        915                 920                 925             


Ser Thr Ala Ser Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn 
    930                 935                 940                 


Ala Gln Ala Leu Asn Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly 
945                 950                 955                 960 


Ala Ile Ser Ser Val Leu Asn Asp Ile Leu Ser Arg Leu Asp Pro Pro 
                965                 970                 975     


Glu Ala Glu Val Gln Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser 
            980                 985                 990         


Leu Gln Thr Tyr Val Thr Gln Gln  Leu Ile Arg Ala Ala  Glu Ile Arg 
        995                 1000                 1005             


Ala Ser  Ala Asn Leu Ala Ala  Thr Lys Met Ser Glu  Cys Val Leu 
    1010                 1015                 1020             


Gly Gln  Ser Lys Arg Val Asp  Phe Cys Gly Lys Gly  Tyr His Leu 
    1025                 1030                 1035             


Met Ser  Phe Pro Gln Ser Ala  Pro His Gly Val Val  Phe Leu His 
    1040                 1045                 1050             


Val Thr  Tyr Val Pro Ala Gln  Glu Lys Asn Phe Thr  Thr Ala Pro 
    1055                 1060                 1065             


Ala Ile  Cys His Asp Gly Lys  Ala His Phe Pro Arg  Glu Gly Val 
    1070                 1075                 1080             


Phe Val  Ser Asn Gly Thr His  Trp Phe Val Thr Gln  Arg Asn Phe 
    1085                 1090                 1095             


Tyr Glu  Pro Gln Ile Ile Thr  Thr Asp Asn Thr Phe  Val Ser Gly 
    1100                 1105                 1110             


Asn Cys  Asp Val Val Ile Gly  Ile Val Asn Asn Thr  Val Tyr Asp 
    1115                 1120                 1125             


Pro Leu  Gln Ser Glu Leu Asp  Ser Ile Lys Glu Glu  Leu Asp Lys 
    1130                 1135                 1140             


Ile His  Lys Asn Gly Ser Gly  Gly Ser Gly Asp Ile  Ile Lys Leu 
    1145                 1150                 1155             


Leu Asn  Glu Gln Val Asn Lys  Glu Met Gln Ser Ser  Asn Leu Tyr 
    1160                 1165                 1170             


Met Ser  Met Ser Ser Trp Cys  Tyr Thr His Ser Leu  Asp Gly Ala 
    1175                 1180                 1185             


Gly Leu  Phe Leu Phe Asp His  Ala Ala Glu Glu Tyr  Glu His Ala 
    1190                 1195                 1200             


Lys Lys  Leu Ile Ile Phe Leu  Asn Glu Asn Asn Val  Pro Val Gln 
    1205                 1210                 1215             


Leu Thr  Ser Ile Ser Ala Pro  Glu His Lys Phe Glu  Gly Leu Thr 
    1220                 1225                 1230             


Gln Ile  Phe Gln Lys Ala Tyr  Glu His Glu Gln His  Ile Ser Glu 
    1235                 1240                 1245             


Ser Ile  Asn Asn Ile Val Asp  His Ala Ile Lys Ser  Lys Asp His 
    1250                 1255                 1260             


Ala Thr  Phe Asn Phe Leu Gln  Trp Tyr Val Ala Glu  Gln His Glu 
    1265                 1270                 1275             


Glu Glu  Val Leu Phe Lys Asp  Ile Leu Asp Lys Ile  Glu Leu Ile 
    1280                 1285                 1290             


Gly Asn  Glu Asn His Gly Leu  Tyr Leu Ala Asp Gln  Tyr Val Lys 
    1295                 1300                 1305             


Gly Ile  Ala Lys Ser Arg Lys  Ser Gly Ser 
    1310                 1315             


<210> 161
<211> 1310
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 161
Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser 
1               5                   10                  15      


Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val 
            20                  25                  30          


Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr 
        35                  40                  45              


Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe 
    50                  55                  60                  


Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr 
65                  70                  75                  80  


Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp 
                85                  90                  95      


Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val 
            100                 105                 110         


Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val 
        115                 120                 125             


Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val 
    130                 135                 140                 


Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe 
145                 150                 155                 160 


Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu 
                165                 170                 175     


Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His 
            180                 185                 190         


Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu 
        195                 200                 205             


Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln 
    210                 215                 220                 


Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser 
225                 230                 235                 240 


Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln 
                245                 250                 255     


Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp 
            260                 265                 270         


Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu 
        275                 280                 285             


Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg 
    290                 295                 300                 


Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu 
305                 310                 315                 320 


Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr 
                325                 330                 335     


Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val 
            340                 345                 350         


Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser 
        355                 360                 365             


Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser 
    370                 375                 380                 


Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr 
385                 390                 395                 400 


Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly 
                405                 410                 415     


Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly 
            420                 425                 430         


Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro 
        435                 440                 445             


Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro 
    450                 455                 460                 


Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr 
465                 470                 475                 480 


Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val 
                485                 490                 495     


Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro 
            500                 505                 510         


Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe 
        515                 520                 525             


Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe 
    530                 535                 540                 


Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala 
545                 550                 555                 560 


Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser 
                565                 570                 575     


Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln 
            580                 585                 590         


Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala 
        595                 600                 605             


Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly 
    610                 615                 620                 


Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His 
625                 630                 635                 640 


Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys 
                645                 650                 655     


Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro Gly Ser Ala Ser Ser Val 
            660                 665                 670         


Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn 
        675                 680                 685             


Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr 
    690                 695                 700                 


Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser 
705                 710                 715                 720 


Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn 
                725                 730                 735     


Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu 
            740                 745                 750         


Thr Gly Ile Ala Val Glu Gln Asp Lys Cys Thr Gln Glu Val Phe Ala 
        755                 760                 765             


Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly 
    770                 775                 780                 


Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg 
785                 790                 795                 800 


Ser Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala 
                805                 810                 815     


Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg 
            820                 825                 830         


Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro 
        835                 840                 845             


Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala 
    850                 855                 860                 


Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln 
865                 870                 875                 880 


Ile Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val 
                885                 890                 895     


Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe 
            900                 905                 910         


Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser 
        915                 920                 925             


Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu 
    930                 935                 940                 


Asn Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser 
945                 950                 955                 960 


Val Leu Asn Asp Ile Leu Ser Arg Leu Asp Pro Pro Glu Ala Glu Val 
                965                 970                 975     


Gln Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser Leu Gln Thr Tyr 
            980                 985                 990         


Val Thr Gln Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Cys Asn 
        995                 1000                 1005             


Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1010                 1015                 1020             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1025                 1030                 1035             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1040                 1045                 1050             


Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1055                 1060                 1065             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1070                 1075                 1080             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1085                 1090                 1095             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1100                 1105                 1110             


Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro 
    1115                 1120                 1125             


Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Gly  Ser Gly Gly 
    1130                 1135                 1140             


Ser Gly  Asp Ile Ile Lys Leu  Leu Asn Glu Gln Val  Asn Lys Glu 
    1145                 1150                 1155             


Met Gln  Ser Ser Asn Leu Tyr  Met Ser Met Ser Ser  Trp Cys Tyr 
    1160                 1165                 1170             


Thr His  Ser Leu Asp Gly Ala  Gly Leu Phe Leu Phe  Asp His Ala 
    1175                 1180                 1185             


Ala Glu  Glu Tyr Glu His Ala  Lys Lys Leu Ile Ile  Phe Leu Asn 
    1190                 1195                 1200             


Glu Asn  Asn Val Pro Val Gln  Leu Thr Ser Ile Ser  Ala Pro Glu 
    1205                 1210                 1215             


His Lys  Phe Glu Gly Leu Thr  Gln Ile Phe Gln Lys  Ala Tyr Glu 
    1220                 1225                 1230             


His Glu  Gln His Ile Ser Glu  Ser Ile Asn Asn Ile  Val Asp His 
    1235                 1240                 1245             


Ala Ile  Lys Ser Lys Asp His  Ala Thr Phe Asn Phe  Leu Gln Trp 
    1250                 1255                 1260             


Tyr Val  Ala Glu Gln His Glu  Glu Glu Val Leu Phe  Lys Asp Ile 
    1265                 1270                 1275             


Leu Asp  Lys Ile Glu Leu Ile  Gly Asn Glu Asn His  Gly Leu Tyr 
    1280                 1285                 1290             


Leu Ala  Asp Gln Tyr Val Lys  Gly Ile Ala Lys Ser  Arg Lys Ser 
    1295                 1300                 1305             


Gly Ser  
    1310 


<210> 162
<211> 1318
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 162
Ser Ser Gln Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala 
1               5                   10                  15      


Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe 
            20                  25                  30          


Arg Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe 
        35                  40                  45              


Ser Asn Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly 
    50                  55                  60                  


Thr Lys Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr 
65                  70                  75                  80  


Phe Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly 
                85                  90                  95      


Thr Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala 
            100                 105                 110         


Thr Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro 
        115                 120                 125             


Phe Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser 
    130                 135                 140                 


Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val 
145                 150                 155                 160 


Ser Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys 
                165                 170                 175     


Asn Leu Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile 
            180                 185                 190         


Tyr Ser Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly 
        195                 200                 205             


Phe Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile 
    210                 215                 220                 


Thr Arg Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro 
225                 230                 235                 240 


Gly Asp Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val 
                245                 250                 255     


Gly Tyr Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly 
            260                 265                 270         


Thr Ile Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr 
        275                 280                 285             


Lys Cys Thr Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr 
    290                 295                 300                 


Ser Asn Phe Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn 
305                 310                 315                 320 


Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe 
                325                 330                 335     


Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala 
            340                 345                 350         


Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys 
        355                 360                 365             


Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val 
    370                 375                 380                 


Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala 
385                 390                 395                 400 


Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp 
                405                 410                 415     


Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser 
            420                 425                 430         


Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser 
        435                 440                 445             


Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala 
    450                 455                 460                 


Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro 
465                 470                 475                 480 


Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro 
                485                 490                 495     


Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr 
            500                 505                 510         


Val Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val 
        515                 520                 525             


Asn Phe Asn Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser 
    530                 535                 540                 


Asn Lys Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp 
545                 550                 555                 560 


Thr Thr Asp Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile 
                565                 570                 575     


Thr Pro Cys Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn 
            580                 585                 590         


Thr Ser Asn Gln Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu 
        595                 600                 605             


Val Pro Val Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val 
    610                 615                 620                 


Tyr Ser Thr Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile 
625                 630                 635                 640 


Gly Ala Glu His Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly 
                645                 650                 655     


Ala Gly Ile Cys Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro Gly Ser 
            660                 665                 670         


Ala Ser Ser Val Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu 
        675                 680                 685             


Gly Ala Glu Asn Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro 
    690                 695                 700                 


Thr Asn Phe Thr Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met 
705                 710                 715                 720 


Thr Lys Thr Ser Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr 
                725                 730                 735     


Glu Cys Ser Asn Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu 
            740                 745                 750         


Asn Arg Ala Leu Thr Gly Ile Ala Val Glu Gln Asp Lys Cys Thr Gln 
        755                 760                 765             


Glu Val Phe Ala Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys 
    770                 775                 780                 


Asp Phe Gly Gly Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys 
785                 790                 795                 800 


Pro Ser Lys Arg Ser Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr 
                805                 810                 815     


Leu Ala Asp Ala Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp 
            820                 825                 830         


Ile Ala Ala Arg Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr 
        835                 840                 845             


Val Leu Pro Pro Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser 
    850                 855                 860                 


Ala Leu Leu Ala Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly 
865                 870                 875                 880 


Ala Ala Leu Gln Ile Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn 
                885                 890                 895     


Gly Ile Gly Val Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile 
            900                 905                 910         


Ala Asn Gln Phe Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser 
        915                 920                 925             


Ser Thr Ala Ser Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn 
    930                 935                 940                 


Ala Gln Ala Leu Asn Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly 
945                 950                 955                 960 


Ala Ile Ser Ser Val Leu Asn Asp Ile Leu Ser Arg Leu Asp Pro Pro 
                965                 970                 975     


Glu Ala Glu Val Gln Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser 
            980                 985                 990         


Leu Gln Thr Tyr Val Thr Gln Gln  Leu Ile Arg Ala Ala  Glu Ile Arg 
        995                 1000                 1005             


Ala Ser  Cys Asn Leu Ala Ala  Thr Lys Met Ser Glu  Cys Val Leu 
    1010                 1015                 1020             


Gly Gln  Ser Lys Arg Val Asp  Phe Cys Gly Lys Gly  Tyr His Leu 
    1025                 1030                 1035             


Met Ser  Phe Pro Gln Ser Ala  Pro His Gly Val Val  Phe Leu His 
    1040                 1045                 1050             


Val Thr  Tyr Val Pro Ala Gln  Glu Lys Asn Phe Thr  Thr Ala Pro 
    1055                 1060                 1065             


Ala Ile  Cys His Asp Gly Lys  Ala His Phe Pro Arg  Glu Gly Val 
    1070                 1075                 1080             


Phe Val  Ser Asn Gly Thr His  Trp Phe Val Thr Gln  Arg Asn Phe 
    1085                 1090                 1095             


Tyr Glu  Pro Gln Ile Ile Thr  Thr Asp Asn Thr Phe  Val Ser Gly 
    1100                 1105                 1110             


Asn Cys  Asp Val Val Ile Gly  Ile Val Asn Asn Thr  Val Tyr Asp 
    1115                 1120                 1125             


Pro Leu  Gln Ser Glu Leu Asp  Ser Ile Lys Glu Glu  Leu Asp Lys 
    1130                 1135                 1140             


Ile His  Lys Asn Gly Ser Gly  Gly Ser Gly Asp Ile  Ile Lys Leu 
    1145                 1150                 1155             


Leu Asn  Glu Gln Val Asn Lys  Glu Met Gln Ser Ser  Asn Leu Tyr 
    1160                 1165                 1170             


Met Ser  Met Ser Ser Trp Cys  Tyr Thr His Ser Leu  Asp Gly Ala 
    1175                 1180                 1185             


Gly Leu  Phe Leu Phe Asp His  Ala Ala Glu Glu Tyr  Glu His Ala 
    1190                 1195                 1200             


Lys Lys  Leu Ile Ile Phe Leu  Asn Glu Asn Asn Val  Pro Val Gln 
    1205                 1210                 1215             


Leu Thr  Ser Ile Ser Ala Pro  Glu His Lys Phe Glu  Gly Leu Thr 
    1220                 1225                 1230             


Gln Ile  Phe Gln Lys Ala Tyr  Glu His Glu Gln His  Ile Ser Glu 
    1235                 1240                 1245             


Ser Ile  Asn Asn Ile Val Asp  His Ala Ile Lys Ser  Lys Asp His 
    1250                 1255                 1260             


Ala Thr  Phe Asn Phe Leu Gln  Trp Tyr Val Ala Glu  Gln His Glu 
    1265                 1270                 1275             


Glu Glu  Val Leu Phe Lys Asp  Ile Leu Asp Lys Ile  Glu Leu Ile 
    1280                 1285                 1290             


Gly Asn  Glu Asn His Gly Leu  Tyr Leu Ala Asp Gln  Tyr Val Lys 
    1295                 1300                 1305             


Gly Ile  Ala Lys Ser Arg Lys  Ser Gly Ser 
    1310                 1315             


<210> 163
<211> 1310
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 163
Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser 
1               5                   10                  15      


Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val 
            20                  25                  30          


Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr 
        35                  40                  45              


Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe 
    50                  55                  60                  


Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr 
65                  70                  75                  80  


Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp 
                85                  90                  95      


Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val 
            100                 105                 110         


Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val 
        115                 120                 125             


Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val 
    130                 135                 140                 


Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe 
145                 150                 155                 160 


Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu 
                165                 170                 175     


Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His 
            180                 185                 190         


Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu 
        195                 200                 205             


Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln 
    210                 215                 220                 


Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser 
225                 230                 235                 240 


Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln 
                245                 250                 255     


Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp 
            260                 265                 270         


Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu 
        275                 280                 285             


Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg 
    290                 295                 300                 


Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu 
305                 310                 315                 320 


Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr 
                325                 330                 335     


Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val 
            340                 345                 350         


Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser 
        355                 360                 365             


Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser 
    370                 375                 380                 


Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr 
385                 390                 395                 400 


Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly 
                405                 410                 415     


Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly 
            420                 425                 430         


Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro 
        435                 440                 445             


Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro 
    450                 455                 460                 


Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr 
465                 470                 475                 480 


Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val 
                485                 490                 495     


Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro 
            500                 505                 510         


Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe 
        515                 520                 525             


Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe 
    530                 535                 540                 


Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala 
545                 550                 555                 560 


Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser 
                565                 570                 575     


Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln 
            580                 585                 590         


Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala 
        595                 600                 605             


Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly 
    610                 615                 620                 


Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His 
625                 630                 635                 640 


Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys 
                645                 650                 655     


Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro Gly Ser Ala Ser Ser Val 
            660                 665                 670         


Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn 
        675                 680                 685             


Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr 
    690                 695                 700                 


Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Cys Thr Ser 
705                 710                 715                 720 


Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn 
                725                 730                 735     


Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu 
            740                 745                 750         


Thr Gly Ile Cys Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala 
        755                 760                 765             


Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly 
    770                 775                 780                 


Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg 
785                 790                 795                 800 


Ser Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala 
                805                 810                 815     


Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg 
            820                 825                 830         


Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro 
        835                 840                 845             


Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala 
    850                 855                 860                 


Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln 
865                 870                 875                 880 


Ile Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val 
                885                 890                 895     


Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe 
            900                 905                 910         


Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser 
        915                 920                 925             


Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu 
    930                 935                 940                 


Asn Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser 
945                 950                 955                 960 


Val Leu Asn Asp Ile Leu Ser Arg Leu Asp Pro Pro Glu Ala Glu Val 
                965                 970                 975     


Gln Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser Leu Gln Thr Tyr 
            980                 985                 990         


Val Thr Gln Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
        995                 1000                 1005             


Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1010                 1015                 1020             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1025                 1030                 1035             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1040                 1045                 1050             


Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1055                 1060                 1065             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1070                 1075                 1080             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1085                 1090                 1095             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1100                 1105                 1110             


Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro 
    1115                 1120                 1125             


Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Gly  Ser Gly Gly 
    1130                 1135                 1140             


Ser Gly  Asp Ile Ile Lys Leu  Leu Asn Glu Gln Val  Asn Lys Glu 
    1145                 1150                 1155             


Met Gln  Ser Ser Asn Leu Tyr  Met Ser Met Ser Ser  Trp Cys Tyr 
    1160                 1165                 1170             


Thr His  Ser Leu Asp Gly Ala  Gly Leu Phe Leu Phe  Asp His Ala 
    1175                 1180                 1185             


Ala Glu  Glu Tyr Glu His Ala  Lys Lys Leu Ile Ile  Phe Leu Asn 
    1190                 1195                 1200             


Glu Asn  Asn Val Pro Val Gln  Leu Thr Ser Ile Ser  Ala Pro Glu 
    1205                 1210                 1215             


His Lys  Phe Glu Gly Leu Thr  Gln Ile Phe Gln Lys  Ala Tyr Glu 
    1220                 1225                 1230             


His Glu  Gln His Ile Ser Glu  Ser Ile Asn Asn Ile  Val Asp His 
    1235                 1240                 1245             


Ala Ile  Lys Ser Lys Asp His  Ala Thr Phe Asn Phe  Leu Gln Trp 
    1250                 1255                 1260             


Tyr Val  Ala Glu Gln His Glu  Glu Glu Val Leu Phe  Lys Asp Ile 
    1265                 1270                 1275             


Leu Asp  Lys Ile Glu Leu Ile  Gly Asn Glu Asn His  Gly Leu Tyr 
    1280                 1285                 1290             


Leu Ala  Asp Gln Tyr Val Lys  Gly Ile Ala Lys Ser  Arg Lys Ser 
    1295                 1300                 1305             


Gly Ser  
    1310 


<210> 164
<211> 1318
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 164
Ser Ser Gln Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala 
1               5                   10                  15      


Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe 
            20                  25                  30          


Arg Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe 
        35                  40                  45              


Ser Asn Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly 
    50                  55                  60                  


Thr Lys Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr 
65                  70                  75                  80  


Phe Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly 
                85                  90                  95      


Thr Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala 
            100                 105                 110         


Thr Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro 
        115                 120                 125             


Phe Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser 
    130                 135                 140                 


Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val 
145                 150                 155                 160 


Ser Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys 
                165                 170                 175     


Asn Leu Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile 
            180                 185                 190         


Tyr Ser Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly 
        195                 200                 205             


Phe Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile 
    210                 215                 220                 


Thr Arg Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro 
225                 230                 235                 240 


Gly Asp Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val 
                245                 250                 255     


Gly Tyr Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly 
            260                 265                 270         


Thr Ile Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr 
        275                 280                 285             


Lys Cys Thr Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr 
    290                 295                 300                 


Ser Asn Phe Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn 
305                 310                 315                 320 


Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe 
                325                 330                 335     


Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala 
            340                 345                 350         


Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys 
        355                 360                 365             


Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val 
    370                 375                 380                 


Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala 
385                 390                 395                 400 


Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp 
                405                 410                 415     


Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser 
            420                 425                 430         


Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser 
        435                 440                 445             


Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala 
    450                 455                 460                 


Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro 
465                 470                 475                 480 


Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro 
                485                 490                 495     


Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr 
            500                 505                 510         


Val Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val 
        515                 520                 525             


Asn Phe Asn Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser 
    530                 535                 540                 


Asn Lys Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp 
545                 550                 555                 560 


Thr Thr Asp Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile 
                565                 570                 575     


Thr Pro Cys Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn 
            580                 585                 590         


Thr Ser Asn Gln Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu 
        595                 600                 605             


Val Pro Val Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val 
    610                 615                 620                 


Tyr Ser Thr Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile 
625                 630                 635                 640 


Gly Ala Glu His Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly 
                645                 650                 655     


Ala Gly Ile Cys Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro Gly Ser 
            660                 665                 670         


Ala Ser Ser Val Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu 
        675                 680                 685             


Gly Ala Glu Asn Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro 
    690                 695                 700                 


Thr Asn Phe Thr Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met 
705                 710                 715                 720 


Thr Cys Thr Ser Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr 
                725                 730                 735     


Glu Cys Ser Asn Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu 
            740                 745                 750         


Asn Arg Ala Leu Thr Gly Ile Cys Val Glu Gln Asp Lys Asn Thr Gln 
        755                 760                 765             


Glu Val Phe Ala Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys 
    770                 775                 780                 


Asp Phe Gly Gly Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys 
785                 790                 795                 800 


Pro Ser Lys Arg Ser Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr 
                805                 810                 815     


Leu Ala Asp Ala Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp 
            820                 825                 830         


Ile Ala Ala Arg Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr 
        835                 840                 845             


Val Leu Pro Pro Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser 
    850                 855                 860                 


Ala Leu Leu Ala Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly 
865                 870                 875                 880 


Ala Ala Leu Gln Ile Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn 
                885                 890                 895     


Gly Ile Gly Val Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile 
            900                 905                 910         


Ala Asn Gln Phe Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser 
        915                 920                 925             


Ser Thr Ala Ser Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn 
    930                 935                 940                 


Ala Gln Ala Leu Asn Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly 
945                 950                 955                 960 


Ala Ile Ser Ser Val Leu Asn Asp Ile Leu Ser Arg Leu Asp Pro Pro 
                965                 970                 975     


Glu Ala Glu Val Gln Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser 
            980                 985                 990         


Leu Gln Thr Tyr Val Thr Gln Gln  Leu Ile Arg Ala Ala  Glu Ile Arg 
        995                 1000                 1005             


Ala Ser  Ala Asn Leu Ala Ala  Thr Lys Met Ser Glu  Cys Val Leu 
    1010                 1015                 1020             


Gly Gln  Ser Lys Arg Val Asp  Phe Cys Gly Lys Gly  Tyr His Leu 
    1025                 1030                 1035             


Met Ser  Phe Pro Gln Ser Ala  Pro His Gly Val Val  Phe Leu His 
    1040                 1045                 1050             


Val Thr  Tyr Val Pro Ala Gln  Glu Lys Asn Phe Thr  Thr Ala Pro 
    1055                 1060                 1065             


Ala Ile  Cys His Asp Gly Lys  Ala His Phe Pro Arg  Glu Gly Val 
    1070                 1075                 1080             


Phe Val  Ser Asn Gly Thr His  Trp Phe Val Thr Gln  Arg Asn Phe 
    1085                 1090                 1095             


Tyr Glu  Pro Gln Ile Ile Thr  Thr Asp Asn Thr Phe  Val Ser Gly 
    1100                 1105                 1110             


Asn Cys  Asp Val Val Ile Gly  Ile Val Asn Asn Thr  Val Tyr Asp 
    1115                 1120                 1125             


Pro Leu  Gln Ser Glu Leu Asp  Ser Ile Lys Glu Glu  Leu Asp Lys 
    1130                 1135                 1140             


Ile His  Lys Asn Gly Ser Gly  Gly Ser Gly Asp Ile  Ile Lys Leu 
    1145                 1150                 1155             


Leu Asn  Glu Gln Val Asn Lys  Glu Met Gln Ser Ser  Asn Leu Tyr 
    1160                 1165                 1170             


Met Ser  Met Ser Ser Trp Cys  Tyr Thr His Ser Leu  Asp Gly Ala 
    1175                 1180                 1185             


Gly Leu  Phe Leu Phe Asp His  Ala Ala Glu Glu Tyr  Glu His Ala 
    1190                 1195                 1200             


Lys Lys  Leu Ile Ile Phe Leu  Asn Glu Asn Asn Val  Pro Val Gln 
    1205                 1210                 1215             


Leu Thr  Ser Ile Ser Ala Pro  Glu His Lys Phe Glu  Gly Leu Thr 
    1220                 1225                 1230             


Gln Ile  Phe Gln Lys Ala Tyr  Glu His Glu Gln His  Ile Ser Glu 
    1235                 1240                 1245             


Ser Ile  Asn Asn Ile Val Asp  His Ala Ile Lys Ser  Lys Asp His 
    1250                 1255                 1260             


Ala Thr  Phe Asn Phe Leu Gln  Trp Tyr Val Ala Glu  Gln His Glu 
    1265                 1270                 1275             


Glu Glu  Val Leu Phe Lys Asp  Ile Leu Asp Lys Ile  Glu Leu Ile 
    1280                 1285                 1290             


Gly Asn  Glu Asn His Gly Leu  Tyr Leu Ala Asp Gln  Tyr Val Lys 
    1295                 1300                 1305             


Gly Ile  Ala Lys Ser Arg Lys  Ser Gly Ser 
    1310                 1315             


<210> 165
<211> 1310
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 165
Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser 
1               5                   10                  15      


Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val 
            20                  25                  30          


Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr 
        35                  40                  45              


Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe 
    50                  55                  60                  


Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr 
65                  70                  75                  80  


Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp 
                85                  90                  95      


Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val 
            100                 105                 110         


Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val 
        115                 120                 125             


Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val 
    130                 135                 140                 


Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe 
145                 150                 155                 160 


Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu 
                165                 170                 175     


Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His 
            180                 185                 190         


Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu 
        195                 200                 205             


Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln 
    210                 215                 220                 


Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser 
225                 230                 235                 240 


Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln 
                245                 250                 255     


Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp 
            260                 265                 270         


Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu 
        275                 280                 285             


Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg 
    290                 295                 300                 


Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu 
305                 310                 315                 320 


Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr 
                325                 330                 335     


Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val 
            340                 345                 350         


Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser 
        355                 360                 365             


Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser 
    370                 375                 380                 


Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr 
385                 390                 395                 400 


Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly 
                405                 410                 415     


Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly 
            420                 425                 430         


Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro 
        435                 440                 445             


Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro 
    450                 455                 460                 


Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr 
465                 470                 475                 480 


Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val 
                485                 490                 495     


Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro 
            500                 505                 510         


Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe 
        515                 520                 525             


Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe 
    530                 535                 540                 


Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Leu Asp Thr Ile Asp Ala 
545                 550                 555                 560 


Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser 
                565                 570                 575     


Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln 
            580                 585                 590         


Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala 
        595                 600                 605             


Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly 
    610                 615                 620                 


Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His 
625                 630                 635                 640 


Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys 
                645                 650                 655     


Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro Gly Ser Ala Ser Ser Val 
            660                 665                 670         


Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn 
        675                 680                 685             


Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr 
    690                 695                 700                 


Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser 
705                 710                 715                 720 


Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn 
                725                 730                 735     


Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu 
            740                 745                 750         


Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala 
        755                 760                 765             


Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly 
    770                 775                 780                 


Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg 
785                 790                 795                 800 


Ser Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala 
                805                 810                 815     


Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg 
            820                 825                 830         


Asp Leu Ile Cys Ala Gln Lys Tyr Ile Gly Leu Thr Val Leu Pro Pro 
        835                 840                 845             


Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala 
    850                 855                 860                 


Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln 
865                 870                 875                 880 


Ile Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val 
                885                 890                 895     


Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe 
            900                 905                 910         


Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser 
        915                 920                 925             


Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu 
    930                 935                 940                 


Asn Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser 
945                 950                 955                 960 


Val Leu Asn Asp Ile Leu Ser Arg Leu Asp Pro Pro Glu Ala Glu Val 
                965                 970                 975     


Gln Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser Leu Gln Thr Tyr 
            980                 985                 990         


Val Thr Gln Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
        995                 1000                 1005             


Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1010                 1015                 1020             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1025                 1030                 1035             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1040                 1045                 1050             


Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1055                 1060                 1065             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1070                 1075                 1080             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1085                 1090                 1095             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1100                 1105                 1110             


Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro 
    1115                 1120                 1125             


Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Gly  Ser Gly Gly 
    1130                 1135                 1140             


Ser Gly  Asp Ile Ile Lys Leu  Leu Asn Glu Gln Val  Asn Lys Glu 
    1145                 1150                 1155             


Met Gln  Ser Ser Asn Leu Tyr  Met Ser Met Ser Ser  Trp Cys Tyr 
    1160                 1165                 1170             


Thr His  Ser Leu Asp Gly Ala  Gly Leu Phe Leu Phe  Asp His Ala 
    1175                 1180                 1185             


Ala Glu  Glu Tyr Glu His Ala  Lys Lys Leu Ile Ile  Phe Leu Asn 
    1190                 1195                 1200             


Glu Asn  Asn Val Pro Val Gln  Leu Thr Ser Ile Ser  Ala Pro Glu 
    1205                 1210                 1215             


His Lys  Phe Glu Gly Leu Thr  Gln Ile Phe Gln Lys  Ala Tyr Glu 
    1220                 1225                 1230             


His Glu  Gln His Ile Ser Glu  Ser Ile Asn Asn Ile  Val Asp His 
    1235                 1240                 1245             


Ala Ile  Lys Ser Lys Asp His  Ala Thr Phe Asn Phe  Leu Gln Trp 
    1250                 1255                 1260             


Tyr Val  Ala Glu Gln His Glu  Glu Glu Val Leu Phe  Lys Asp Ile 
    1265                 1270                 1275             


Leu Asp  Lys Ile Glu Leu Ile  Gly Asn Glu Asn His  Gly Leu Tyr 
    1280                 1285                 1290             


Leu Ala  Asp Gln Tyr Val Lys  Gly Ile Ala Lys Ser  Arg Lys Ser 
    1295                 1300                 1305             


Gly Ser  
    1310 


<210> 166
<211> 1318
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 166
Ser Ser Gln Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala 
1               5                   10                  15      


Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe 
            20                  25                  30          


Arg Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe 
        35                  40                  45              


Ser Asn Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly 
    50                  55                  60                  


Thr Lys Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr 
65                  70                  75                  80  


Phe Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly 
                85                  90                  95      


Thr Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala 
            100                 105                 110         


Thr Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro 
        115                 120                 125             


Phe Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser 
    130                 135                 140                 


Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val 
145                 150                 155                 160 


Ser Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys 
                165                 170                 175     


Asn Leu Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile 
            180                 185                 190         


Tyr Ser Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly 
        195                 200                 205             


Phe Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile 
    210                 215                 220                 


Thr Arg Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro 
225                 230                 235                 240 


Gly Asp Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val 
                245                 250                 255     


Gly Tyr Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly 
            260                 265                 270         


Thr Ile Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr 
        275                 280                 285             


Lys Cys Thr Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr 
    290                 295                 300                 


Ser Asn Phe Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn 
305                 310                 315                 320 


Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe 
                325                 330                 335     


Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala 
            340                 345                 350         


Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys 
        355                 360                 365             


Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val 
    370                 375                 380                 


Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala 
385                 390                 395                 400 


Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp 
                405                 410                 415     


Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser 
            420                 425                 430         


Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser 
        435                 440                 445             


Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala 
    450                 455                 460                 


Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro 
465                 470                 475                 480 


Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro 
                485                 490                 495     


Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr 
            500                 505                 510         


Val Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val 
        515                 520                 525             


Asn Phe Asn Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser 
    530                 535                 540                 


Asn Lys Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Leu Asp 
545                 550                 555                 560 


Thr Ile Asp Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile 
                565                 570                 575     


Thr Pro Cys Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn 
            580                 585                 590         


Thr Ser Asn Gln Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu 
        595                 600                 605             


Val Pro Val Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val 
    610                 615                 620                 


Tyr Ser Thr Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile 
625                 630                 635                 640 


Gly Ala Glu His Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly 
                645                 650                 655     


Ala Gly Ile Cys Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro Gly Ser 
            660                 665                 670         


Ala Ser Ser Val Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu 
        675                 680                 685             


Gly Ala Glu Asn Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro 
    690                 695                 700                 


Thr Asn Phe Thr Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met 
705                 710                 715                 720 


Thr Lys Thr Ser Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr 
                725                 730                 735     


Glu Cys Ser Asn Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu 
            740                 745                 750         


Asn Arg Ala Leu Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln 
        755                 760                 765             


Glu Val Phe Ala Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys 
    770                 775                 780                 


Asp Phe Gly Gly Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys 
785                 790                 795                 800 


Pro Ser Lys Arg Ser Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr 
                805                 810                 815     


Leu Ala Asp Ala Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp 
            820                 825                 830         


Ile Ala Ala Arg Asp Leu Ile Cys Ala Gln Lys Tyr Ile Gly Leu Thr 
        835                 840                 845             


Val Leu Pro Pro Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser 
    850                 855                 860                 


Ala Leu Leu Ala Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly 
865                 870                 875                 880 


Ala Ala Leu Gln Ile Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn 
                885                 890                 895     


Gly Ile Gly Val Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile 
            900                 905                 910         


Ala Asn Gln Phe Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser 
        915                 920                 925             


Ser Thr Ala Ser Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn 
    930                 935                 940                 


Ala Gln Ala Leu Asn Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly 
945                 950                 955                 960 


Ala Ile Ser Ser Val Leu Asn Asp Ile Leu Ser Arg Leu Asp Pro Pro 
                965                 970                 975     


Glu Ala Glu Val Gln Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser 
            980                 985                 990         


Leu Gln Thr Tyr Val Thr Gln Gln  Leu Ile Arg Ala Ala  Glu Ile Arg 
        995                 1000                 1005             


Ala Ser  Ala Asn Leu Ala Ala  Thr Lys Met Ser Glu  Cys Val Leu 
    1010                 1015                 1020             


Gly Gln  Ser Lys Arg Val Asp  Phe Cys Gly Lys Gly  Tyr His Leu 
    1025                 1030                 1035             


Met Ser  Phe Pro Gln Ser Ala  Pro His Gly Val Val  Phe Leu His 
    1040                 1045                 1050             


Val Thr  Tyr Val Pro Ala Gln  Glu Lys Asn Phe Thr  Thr Ala Pro 
    1055                 1060                 1065             


Ala Ile  Cys His Asp Gly Lys  Ala His Phe Pro Arg  Glu Gly Val 
    1070                 1075                 1080             


Phe Val  Ser Asn Gly Thr His  Trp Phe Val Thr Gln  Arg Asn Phe 
    1085                 1090                 1095             


Tyr Glu  Pro Gln Ile Ile Thr  Thr Asp Asn Thr Phe  Val Ser Gly 
    1100                 1105                 1110             


Asn Cys  Asp Val Val Ile Gly  Ile Val Asn Asn Thr  Val Tyr Asp 
    1115                 1120                 1125             


Pro Leu  Gln Ser Glu Leu Asp  Ser Ile Lys Glu Glu  Leu Asp Lys 
    1130                 1135                 1140             


Ile His  Lys Asn Gly Ser Gly  Gly Ser Gly Asp Ile  Ile Lys Leu 
    1145                 1150                 1155             


Leu Asn  Glu Gln Val Asn Lys  Glu Met Gln Ser Ser  Asn Leu Tyr 
    1160                 1165                 1170             


Met Ser  Met Ser Ser Trp Cys  Tyr Thr His Ser Leu  Asp Gly Ala 
    1175                 1180                 1185             


Gly Leu  Phe Leu Phe Asp His  Ala Ala Glu Glu Tyr  Glu His Ala 
    1190                 1195                 1200             


Lys Lys  Leu Ile Ile Phe Leu  Asn Glu Asn Asn Val  Pro Val Gln 
    1205                 1210                 1215             


Leu Thr  Ser Ile Ser Ala Pro  Glu His Lys Phe Glu  Gly Leu Thr 
    1220                 1225                 1230             


Gln Ile  Phe Gln Lys Ala Tyr  Glu His Glu Gln His  Ile Ser Glu 
    1235                 1240                 1245             


Ser Ile  Asn Asn Ile Val Asp  His Ala Ile Lys Ser  Lys Asp His 
    1250                 1255                 1260             


Ala Thr  Phe Asn Phe Leu Gln  Trp Tyr Val Ala Glu  Gln His Glu 
    1265                 1270                 1275             


Glu Glu  Val Leu Phe Lys Asp  Ile Leu Asp Lys Ile  Glu Leu Ile 
    1280                 1285                 1290             


Gly Asn  Glu Asn His Gly Leu  Tyr Leu Ala Asp Gln  Tyr Val Lys 
    1295                 1300                 1305             


Gly Ile  Ala Lys Ser Arg Lys  Ser Gly Ser 
    1310                 1315             


<210> 167
<211> 1310
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 167
Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser 
1               5                   10                  15      


Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val 
            20                  25                  30          


Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr 
        35                  40                  45              


Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe 
    50                  55                  60                  


Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr 
65                  70                  75                  80  


Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp 
                85                  90                  95      


Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val 
            100                 105                 110         


Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val 
        115                 120                 125             


Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val 
    130                 135                 140                 


Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe 
145                 150                 155                 160 


Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu 
                165                 170                 175     


Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His 
            180                 185                 190         


Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu 
        195                 200                 205             


Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln 
    210                 215                 220                 


Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser 
225                 230                 235                 240 


Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln 
                245                 250                 255     


Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp 
            260                 265                 270         


Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu 
        275                 280                 285             


Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg 
    290                 295                 300                 


Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu 
305                 310                 315                 320 


Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr 
                325                 330                 335     


Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val 
            340                 345                 350         


Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser 
        355                 360                 365             


Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser 
    370                 375                 380                 


Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr 
385                 390                 395                 400 


Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly 
                405                 410                 415     


Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly 
            420                 425                 430         


Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro 
        435                 440                 445             


Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro 
    450                 455                 460                 


Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr 
465                 470                 475                 480 


Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val 
                485                 490                 495     


Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro 
            500                 505                 510         


Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe 
        515                 520                 525             


Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe 
    530                 535                 540                 


Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala 
545                 550                 555                 560 


Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser 
                565                 570                 575     


Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln 
            580                 585                 590         


Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala 
        595                 600                 605             


Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly 
    610                 615                 620                 


Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His 
625                 630                 635                 640 


Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys 
                645                 650                 655     


Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro Gly Ser Ala Ser Ser Val 
            660                 665                 670         


Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn 
        675                 680                 685             


Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr 
    690                 695                 700                 


Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser 
705                 710                 715                 720 


Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn 
                725                 730                 735     


Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu 
            740                 745                 750         


Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala 
        755                 760                 765             


Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly 
    770                 775                 780                 


Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg 
785                 790                 795                 800 


Ser Pro Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala 
                805                 810                 815     


Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg 
            820                 825                 830         


Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro 
        835                 840                 845             


Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala 
    850                 855                 860                 


Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Pro Ala Leu Gln 
865                 870                 875                 880 


Ile Pro Phe Pro Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val 
                885                 890                 895     


Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe 
            900                 905                 910         


Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Pro Ser 
        915                 920                 925             


Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu 
    930                 935                 940                 


Asn Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser 
945                 950                 955                 960 


Val Leu Asn Asp Ile Leu Ser Arg Leu Asp Pro Pro Glu Ala Glu Val 
                965                 970                 975     


Gln Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser Leu Gln Thr Tyr 
            980                 985                 990         


Val Thr Gln Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
        995                 1000                 1005             


Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1010                 1015                 1020             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1025                 1030                 1035             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1040                 1045                 1050             


Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1055                 1060                 1065             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1070                 1075                 1080             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1085                 1090                 1095             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1100                 1105                 1110             


Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro 
    1115                 1120                 1125             


Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Gly  Ser Gly Gly 
    1130                 1135                 1140             


Ser Gly  Asp Ile Ile Lys Leu  Leu Asn Glu Gln Val  Asn Lys Glu 
    1145                 1150                 1155             


Met Gln  Ser Ser Asn Leu Tyr  Met Ser Met Ser Ser  Trp Cys Tyr 
    1160                 1165                 1170             


Thr His  Ser Leu Asp Gly Ala  Gly Leu Phe Leu Phe  Asp His Ala 
    1175                 1180                 1185             


Ala Glu  Glu Tyr Glu His Ala  Lys Lys Leu Ile Ile  Phe Leu Asn 
    1190                 1195                 1200             


Glu Asn  Asn Val Pro Val Gln  Leu Thr Ser Ile Ser  Ala Pro Glu 
    1205                 1210                 1215             


His Lys  Phe Glu Gly Leu Thr  Gln Ile Phe Gln Lys  Ala Tyr Glu 
    1220                 1225                 1230             


His Glu  Gln His Ile Ser Glu  Ser Ile Asn Asn Ile  Val Asp His 
    1235                 1240                 1245             


Ala Ile  Lys Ser Lys Asp His  Ala Thr Phe Asn Phe  Leu Gln Trp 
    1250                 1255                 1260             


Tyr Val  Ala Glu Gln His Glu  Glu Glu Val Leu Phe  Lys Asp Ile 
    1265                 1270                 1275             


Leu Asp  Lys Ile Glu Leu Ile  Gly Asn Glu Asn His  Gly Leu Tyr 
    1280                 1285                 1290             


Leu Ala  Asp Gln Tyr Val Lys  Gly Ile Ala Lys Ser  Arg Lys Ser 
    1295                 1300                 1305             


Gly Ser  
    1310 


<210> 168
<211> 1318
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 168
Ser Ser Gln Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala 
1               5                   10                  15      


Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe 
            20                  25                  30          


Arg Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe 
        35                  40                  45              


Ser Asn Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly 
    50                  55                  60                  


Thr Lys Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr 
65                  70                  75                  80  


Phe Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly 
                85                  90                  95      


Thr Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala 
            100                 105                 110         


Thr Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro 
        115                 120                 125             


Phe Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser 
    130                 135                 140                 


Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val 
145                 150                 155                 160 


Ser Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys 
                165                 170                 175     


Asn Leu Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile 
            180                 185                 190         


Tyr Ser Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly 
        195                 200                 205             


Phe Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile 
    210                 215                 220                 


Thr Arg Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro 
225                 230                 235                 240 


Gly Asp Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val 
                245                 250                 255     


Gly Tyr Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly 
            260                 265                 270         


Thr Ile Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr 
        275                 280                 285             


Lys Cys Thr Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr 
    290                 295                 300                 


Ser Asn Phe Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn 
305                 310                 315                 320 


Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe 
                325                 330                 335     


Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala 
            340                 345                 350         


Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys 
        355                 360                 365             


Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val 
    370                 375                 380                 


Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala 
385                 390                 395                 400 


Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp 
                405                 410                 415     


Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser 
            420                 425                 430         


Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser 
        435                 440                 445             


Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala 
    450                 455                 460                 


Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro 
465                 470                 475                 480 


Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro 
                485                 490                 495     


Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr 
            500                 505                 510         


Val Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val 
        515                 520                 525             


Asn Phe Asn Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser 
    530                 535                 540                 


Asn Lys Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp 
545                 550                 555                 560 


Thr Thr Asp Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile 
                565                 570                 575     


Thr Pro Cys Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn 
            580                 585                 590         


Thr Ser Asn Gln Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu 
        595                 600                 605             


Val Pro Val Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val 
    610                 615                 620                 


Tyr Ser Thr Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile 
625                 630                 635                 640 


Gly Ala Glu His Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly 
                645                 650                 655     


Ala Gly Ile Cys Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro Gly Ser 
            660                 665                 670         


Ala Ser Ser Val Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu 
        675                 680                 685             


Gly Ala Glu Asn Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro 
    690                 695                 700                 


Thr Asn Phe Thr Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met 
705                 710                 715                 720 


Thr Lys Thr Ser Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr 
                725                 730                 735     


Glu Cys Ser Asn Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu 
            740                 745                 750         


Asn Arg Ala Leu Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln 
        755                 760                 765             


Glu Val Phe Ala Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys 
    770                 775                 780                 


Asp Phe Gly Gly Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys 
785                 790                 795                 800 


Pro Ser Lys Arg Ser Pro Ile Glu Asp Leu Leu Phe Asn Lys Val Thr 
                805                 810                 815     


Leu Ala Asp Ala Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp 
            820                 825                 830         


Ile Ala Ala Arg Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr 
        835                 840                 845             


Val Leu Pro Pro Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser 
    850                 855                 860                 


Ala Leu Leu Ala Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly 
865                 870                 875                 880 


Pro Ala Leu Gln Ile Pro Phe Pro Met Gln Met Ala Tyr Arg Phe Asn 
                885                 890                 895     


Gly Ile Gly Val Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile 
            900                 905                 910         


Ala Asn Gln Phe Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser 
        915                 920                 925             


Ser Thr Pro Ser Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn 
    930                 935                 940                 


Ala Gln Ala Leu Asn Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly 
945                 950                 955                 960 


Ala Ile Ser Ser Val Leu Asn Asp Ile Leu Ser Arg Leu Asp Pro Pro 
                965                 970                 975     


Glu Ala Glu Val Gln Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser 
            980                 985                 990         


Leu Gln Thr Tyr Val Thr Gln Gln  Leu Ile Arg Ala Ala  Glu Ile Arg 
        995                 1000                 1005             


Ala Ser  Ala Asn Leu Ala Ala  Thr Lys Met Ser Glu  Cys Val Leu 
    1010                 1015                 1020             


Gly Gln  Ser Lys Arg Val Asp  Phe Cys Gly Lys Gly  Tyr His Leu 
    1025                 1030                 1035             


Met Ser  Phe Pro Gln Ser Ala  Pro His Gly Val Val  Phe Leu His 
    1040                 1045                 1050             


Val Thr  Tyr Val Pro Ala Gln  Glu Lys Asn Phe Thr  Thr Ala Pro 
    1055                 1060                 1065             


Ala Ile  Cys His Asp Gly Lys  Ala His Phe Pro Arg  Glu Gly Val 
    1070                 1075                 1080             


Phe Val  Ser Asn Gly Thr His  Trp Phe Val Thr Gln  Arg Asn Phe 
    1085                 1090                 1095             


Tyr Glu  Pro Gln Ile Ile Thr  Thr Asp Asn Thr Phe  Val Ser Gly 
    1100                 1105                 1110             


Asn Cys  Asp Val Val Ile Gly  Ile Val Asn Asn Thr  Val Tyr Asp 
    1115                 1120                 1125             


Pro Leu  Gln Ser Glu Leu Asp  Ser Ile Lys Glu Glu  Leu Asp Lys 
    1130                 1135                 1140             


Ile His  Lys Asn Gly Ser Gly  Gly Ser Gly Asp Ile  Ile Lys Leu 
    1145                 1150                 1155             


Leu Asn  Glu Gln Val Asn Lys  Glu Met Gln Ser Ser  Asn Leu Tyr 
    1160                 1165                 1170             


Met Ser  Met Ser Ser Trp Cys  Tyr Thr His Ser Leu  Asp Gly Ala 
    1175                 1180                 1185             


Gly Leu  Phe Leu Phe Asp His  Ala Ala Glu Glu Tyr  Glu His Ala 
    1190                 1195                 1200             


Lys Lys  Leu Ile Ile Phe Leu  Asn Glu Asn Asn Val  Pro Val Gln 
    1205                 1210                 1215             


Leu Thr  Ser Ile Ser Ala Pro  Glu His Lys Phe Glu  Gly Leu Thr 
    1220                 1225                 1230             


Gln Ile  Phe Gln Lys Ala Tyr  Glu His Glu Gln His  Ile Ser Glu 
    1235                 1240                 1245             


Ser Ile  Asn Asn Ile Val Asp  His Ala Ile Lys Ser  Lys Asp His 
    1250                 1255                 1260             


Ala Thr  Phe Asn Phe Leu Gln  Trp Tyr Val Ala Glu  Gln His Glu 
    1265                 1270                 1275             


Glu Glu  Val Leu Phe Lys Asp  Ile Leu Asp Lys Ile  Glu Leu Ile 
    1280                 1285                 1290             


Gly Asn  Glu Asn His Gly Leu  Tyr Leu Ala Asp Gln  Tyr Val Lys 
    1295                 1300                 1305             


Gly Ile  Ala Lys Ser Arg Lys  Ser Gly Ser 
    1310                 1315             


<210> 169
<211> 1318
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 169
Ser Ser Gln Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala 
1               5                   10                  15      


Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe 
            20                  25                  30          


Arg Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe 
        35                  40                  45              


Ser Asn Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly 
    50                  55                  60                  


Thr Lys Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr 
65                  70                  75                  80  


Phe Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly 
                85                  90                  95      


Thr Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala 
            100                 105                 110         


Thr Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro 
        115                 120                 125             


Phe Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser 
    130                 135                 140                 


Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val 
145                 150                 155                 160 


Ser Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys 
                165                 170                 175     


Asn Leu Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile 
            180                 185                 190         


Tyr Ser Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly 
        195                 200                 205             


Phe Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile 
    210                 215                 220                 


Thr Arg Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro 
225                 230                 235                 240 


Gly Asp Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val 
                245                 250                 255     


Gly Tyr Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly 
            260                 265                 270         


Thr Ile Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr 
        275                 280                 285             


Lys Cys Thr Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr 
    290                 295                 300                 


Ser Asn Phe Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn 
305                 310                 315                 320 


Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe 
                325                 330                 335     


Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala 
            340                 345                 350         


Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys 
        355                 360                 365             


Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val 
    370                 375                 380                 


Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala 
385                 390                 395                 400 


Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp 
                405                 410                 415     


Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser 
            420                 425                 430         


Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser 
        435                 440                 445             


Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala 
    450                 455                 460                 


Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro 
465                 470                 475                 480 


Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro 
                485                 490                 495     


Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr 
            500                 505                 510         


Val Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val 
        515                 520                 525             


Asn Phe Asn Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser 
    530                 535                 540                 


Asn Lys Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp 
545                 550                 555                 560 


Thr Thr Asp Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile 
                565                 570                 575     


Thr Pro Cys Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn 
            580                 585                 590         


Thr Ser Asn Gln Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu 
        595                 600                 605             


Val Pro Val Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val 
    610                 615                 620                 


Tyr Ser Thr Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile 
625                 630                 635                 640 


Gly Ala Glu His Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly 
                645                 650                 655     


Ala Gly Ile Cys Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro Gly Ser 
            660                 665                 670         


Ala Ser Ser Val Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu 
        675                 680                 685             


Gly Ala Glu Asn Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro 
    690                 695                 700                 


Thr Asn Phe Thr Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met 
705                 710                 715                 720 


Thr Lys Thr Ser Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr 
                725                 730                 735     


Glu Cys Ser Asn Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu 
            740                 745                 750         


Asn Arg Ala Leu Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln 
        755                 760                 765             


Glu Val Phe Ala Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys 
    770                 775                 780                 


Asp Phe Gly Gly Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys 
785                 790                 795                 800 


Pro Ser Lys Arg Ser Pro Ile Glu Asp Leu Leu Phe Asn Lys Val Thr 
                805                 810                 815     


Leu Ala Asp Ala Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp 
            820                 825                 830         


Ile Ala Ala Arg Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr 
        835                 840                 845             


Val Leu Pro Pro Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser 
    850                 855                 860                 


Ala Leu Leu Ala Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly 
865                 870                 875                 880 


Pro Ala Leu Gln Ile Pro Phe Pro Met Gln Met Ala Tyr Arg Phe Asn 
                885                 890                 895     


Gly Ile Gly Val Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile 
            900                 905                 910         


Ala Asn Gln Phe Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser 
        915                 920                 925             


Ser Thr Pro Ser Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn 
    930                 935                 940                 


Ala Gln Ala Leu Asn Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly 
945                 950                 955                 960 


Ala Ile Ser Ser Val Leu Asn Asp Ile Leu Ser Arg Leu Asp Pro Pro 
                965                 970                 975     


Glu Ala Glu Val Gln Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser 
            980                 985                 990         


Leu Gln Thr Tyr Val Thr Gln Gln  Leu Ile Arg Ala Ala  Glu Ile Arg 
        995                 1000                 1005             


Ala Ser  Ala Asn Leu Ala Ala  Thr Lys Met Ser Glu  Cys Val Leu 
    1010                 1015                 1020             


Gly Gln  Ser Lys Arg Val Asp  Phe Cys Gly Lys Gly  Tyr His Leu 
    1025                 1030                 1035             


Met Ser  Phe Pro Gln Ser Ala  Pro His Gly Val Val  Phe Leu His 
    1040                 1045                 1050             


Val Thr  Tyr Val Pro Ala Gln  Glu Lys Asn Phe Thr  Thr Ala Pro 
    1055                 1060                 1065             


Ala Ile  Cys His Asp Gly Lys  Ala His Phe Pro Arg  Glu Gly Val 
    1070                 1075                 1080             


Phe Val  Ser Asn Gly Thr His  Trp Phe Val Thr Gln  Arg Asn Phe 
    1085                 1090                 1095             


Tyr Glu  Pro Gln Ile Ile Thr  Thr Asp Asn Thr Phe  Val Ser Gly 
    1100                 1105                 1110             


Asn Cys  Asp Val Val Ile Gly  Ile Val Asn Asn Thr  Val Tyr Asp 
    1115                 1120                 1125             


Pro Leu  Gln Pro Glu Leu Asp  Ser Ile Lys Glu Glu  Leu Asp Lys 
    1130                 1135                 1140             


Ile His  Lys Asn Gly Ser Gly  Gly Ser Gly Asp Ile  Ile Lys Leu 
    1145                 1150                 1155             


Leu Asn  Glu Gln Val Asn Lys  Glu Met Gln Ser Ser  Asn Leu Tyr 
    1160                 1165                 1170             


Met Ser  Met Ser Ser Trp Cys  Tyr Thr His Ser Leu  Asp Gly Ala 
    1175                 1180                 1185             


Gly Leu  Phe Leu Phe Asp His  Ala Ala Glu Glu Tyr  Glu His Ala 
    1190                 1195                 1200             


Lys Lys  Leu Ile Ile Phe Leu  Asn Glu Asn Asn Val  Pro Val Gln 
    1205                 1210                 1215             


Leu Thr  Ser Ile Ser Ala Pro  Glu His Lys Phe Glu  Gly Leu Thr 
    1220                 1225                 1230             


Gln Ile  Phe Gln Lys Ala Tyr  Glu His Glu Gln His  Ile Ser Glu 
    1235                 1240                 1245             


Ser Ile  Asn Asn Ile Val Asp  His Ala Ile Lys Ser  Lys Asp His 
    1250                 1255                 1260             


Ala Thr  Phe Asn Phe Leu Gln  Trp Tyr Val Ala Glu  Gln His Glu 
    1265                 1270                 1275             


Glu Glu  Val Leu Phe Lys Asp  Ile Leu Asp Lys Ile  Glu Leu Ile 
    1280                 1285                 1290             


Gly Asn  Glu Asn His Gly Leu  Tyr Leu Ala Asp Gln  Tyr Val Lys 
    1295                 1300                 1305             


Gly Ile  Ala Lys Ser Arg Lys  Ser Gly Ser 
    1310                 1315             


<210> 170
<211> 1271
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 170
Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser 
1               5                   10                  15      


Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val 
            20                  25                  30          


Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr 
        35                  40                  45              


Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe 
    50                  55                  60                  


Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr 
65                  70                  75                  80  


Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp 
                85                  90                  95      


Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val 
            100                 105                 110         


Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val 
        115                 120                 125             


Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val 
    130                 135                 140                 


Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe 
145                 150                 155                 160 


Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu 
                165                 170                 175     


Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His 
            180                 185                 190         


Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu 
        195                 200                 205             


Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln 
    210                 215                 220                 


Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser 
225                 230                 235                 240 


Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln 
                245                 250                 255     


Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp 
            260                 265                 270         


Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu 
        275                 280                 285             


Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg 
    290                 295                 300                 


Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu 
305                 310                 315                 320 


Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr 
                325                 330                 335     


Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val 
            340                 345                 350         


Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser 
        355                 360                 365             


Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser 
    370                 375                 380                 


Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr 
385                 390                 395                 400 


Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly 
                405                 410                 415     


Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly 
            420                 425                 430         


Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro 
        435                 440                 445             


Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro 
    450                 455                 460                 


Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr 
465                 470                 475                 480 


Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val 
                485                 490                 495     


Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro 
            500                 505                 510         


Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe 
        515                 520                 525             


Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe 
    530                 535                 540                 


Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala 
545                 550                 555                 560 


Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser 
                565                 570                 575     


Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln 
            580                 585                 590         


Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala 
        595                 600                 605             


Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly 
    610                 615                 620                 


Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His 
625                 630                 635                 640 


Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys 
                645                 650                 655     


Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro Gly Ser Ala Ser Ser Val 
            660                 665                 670         


Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn 
        675                 680                 685             


Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr 
    690                 695                 700                 


Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser 
705                 710                 715                 720 


Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn 
                725                 730                 735     


Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu 
            740                 745                 750         


Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala 
        755                 760                 765             


Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly 
    770                 775                 780                 


Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg 
785                 790                 795                 800 


Ser Pro Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala 
                805                 810                 815     


Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg 
            820                 825                 830         


Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro 
        835                 840                 845             


Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala 
    850                 855                 860                 


Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Pro Ala Leu Gln 
865                 870                 875                 880 


Ile Pro Phe Pro Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val 
                885                 890                 895     


Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe 
            900                 905                 910         


Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Pro Ser 
        915                 920                 925             


Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu 
    930                 935                 940                 


Asn Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser 
945                 950                 955                 960 


Val Leu Asn Asp Ile Leu Ser Arg Leu Asp Pro Pro Glu Ala Glu Val 
                965                 970                 975     


Gln Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser Leu Gln Thr Tyr 
            980                 985                 990         


Val Thr Gln Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
        995                 1000                 1005             


Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1010                 1015                 1020             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1025                 1030                 1035             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1040                 1045                 1050             


Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1055                 1060                 1065             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1070                 1075                 1080             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1085                 1090                 1095             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1100                 1105                 1110             


Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro 
    1115                 1120                 1125             


Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Tyr  Phe Lys Asn 
    1130                 1135                 1140             


His Thr  Ser Pro Asp Val Asp  Leu Gly Asp Ile Ser  Gly Ile Asn 
    1145                 1150                 1155             


Ala Ser  Val Val Asn Ile Gln  Lys Glu Ile Asp Arg  Leu Asn Glu 
    1160                 1165                 1170             


Val Ala  Lys Asn Leu Asn Glu  Ser Leu Ile Asp Leu  Gln Glu Leu 
    1175                 1180                 1185             


Gly Lys  Tyr Glu Gln Gly Ser  Gly Tyr Ile Pro Glu  Ala Pro Arg 
    1190                 1195                 1200             


Asp Gly  Gln Ala Tyr Val Arg  Lys Asp Gly Glu Trp  Val Leu Leu 
    1205                 1210                 1215             


Ser Thr  Phe Leu Gly Leu Glu  Val Leu Phe Gln Gly  Pro Ser Ala 
    1220                 1225                 1230             


Trp Ser  His Pro Gln Phe Glu  Lys Gly Gly Gly Ser  Gly Gly Gly 
    1235                 1240                 1245             


Ser Gly  Gly Ser Ala Trp Ser  His Pro Gln Phe Glu  Lys Gly Ser 
    1250                 1255                 1260             


His His  His His His His His  His 
    1265                 1270     


<210> 171
<211> 1318
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 171
Ser Ser Gln Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala 
1               5                   10                  15      


Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe 
            20                  25                  30          


Arg Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe 
        35                  40                  45              


Ser Asn Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly 
    50                  55                  60                  


Thr Lys Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr 
65                  70                  75                  80  


Phe Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly 
                85                  90                  95      


Thr Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala 
            100                 105                 110         


Thr Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro 
        115                 120                 125             


Phe Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser 
    130                 135                 140                 


Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val 
145                 150                 155                 160 


Ser Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys 
                165                 170                 175     


Asn Leu Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile 
            180                 185                 190         


Tyr Ser Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly 
        195                 200                 205             


Phe Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile 
    210                 215                 220                 


Thr Arg Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro 
225                 230                 235                 240 


Gly Asp Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val 
                245                 250                 255     


Gly Tyr Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly 
            260                 265                 270         


Thr Ile Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr 
        275                 280                 285             


Lys Cys Thr Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr 
    290                 295                 300                 


Ser Asn Phe Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn 
305                 310                 315                 320 


Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe 
                325                 330                 335     


Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala 
            340                 345                 350         


Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys 
        355                 360                 365             


Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val 
    370                 375                 380                 


Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala 
385                 390                 395                 400 


Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp 
                405                 410                 415     


Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser 
            420                 425                 430         


Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser 
        435                 440                 445             


Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala 
    450                 455                 460                 


Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro 
465                 470                 475                 480 


Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro 
                485                 490                 495     


Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr 
            500                 505                 510         


Val Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val 
        515                 520                 525             


Asn Phe Asn Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser 
    530                 535                 540                 


Asn Lys Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp 
545                 550                 555                 560 


Thr Thr Asp Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile 
                565                 570                 575     


Thr Pro Cys Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn 
            580                 585                 590         


Thr Ser Asn Gln Val Ala Val Leu Tyr Gln Gly Val Asn Cys Thr Glu 
        595                 600                 605             


Val Pro Val Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val 
    610                 615                 620                 


Tyr Ser Thr Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile 
625                 630                 635                 640 


Gly Ala Glu His Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly 
                645                 650                 655     


Ala Gly Ile Cys Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro Gly Ser 
            660                 665                 670         


Ala Ser Ser Val Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu 
        675                 680                 685             


Gly Ala Glu Asn Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro 
    690                 695                 700                 


Thr Asn Phe Thr Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met 
705                 710                 715                 720 


Thr Lys Thr Ser Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr 
                725                 730                 735     


Glu Cys Ser Asn Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu 
            740                 745                 750         


Asn Arg Ala Leu Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln 
        755                 760                 765             


Glu Val Phe Ala Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys 
    770                 775                 780                 


Asp Phe Gly Gly Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys 
785                 790                 795                 800 


Pro Ser Lys Arg Ser Pro Ile Glu Asp Leu Leu Phe Asn Lys Val Thr 
                805                 810                 815     


Leu Ala Asp Ala Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp 
            820                 825                 830         


Ile Ala Ala Arg Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr 
        835                 840                 845             


Val Leu Pro Pro Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser 
    850                 855                 860                 


Ala Leu Leu Ala Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly 
865                 870                 875                 880 


Pro Ala Leu Gln Ile Pro Phe Pro Met Gln Met Ala Tyr Arg Phe Asn 
                885                 890                 895     


Gly Ile Gly Val Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile 
            900                 905                 910         


Ala Asn Gln Phe Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser 
        915                 920                 925             


Ser Thr Pro Ser Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn 
    930                 935                 940                 


Ala Gln Ala Leu Asn Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly 
945                 950                 955                 960 


Ala Ile Ser Ser Val Leu Asn Asp Ile Leu Ser Arg Leu Asp Pro Pro 
                965                 970                 975     


Glu Ala Glu Val Gln Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser 
            980                 985                 990         


Leu Gln Thr Tyr Val Thr Gln Gln  Leu Ile Arg Ala Ala  Glu Ile Arg 
        995                 1000                 1005             


Ala Ser  Ala Asn Leu Ala Ala  Thr Lys Met Ser Glu  Cys Val Leu 
    1010                 1015                 1020             


Gly Gln  Ser Lys Arg Val Asp  Phe Cys Gly Lys Gly  Tyr His Leu 
    1025                 1030                 1035             


Met Ser  Phe Pro Gln Ser Ala  Pro His Gly Val Val  Phe Leu His 
    1040                 1045                 1050             


Val Thr  Tyr Val Pro Ala Gln  Glu Lys Asn Phe Thr  Thr Ala Pro 
    1055                 1060                 1065             


Ala Ile  Cys His Asp Gly Lys  Ala His Phe Pro Arg  Glu Gly Val 
    1070                 1075                 1080             


Phe Val  Ser Asn Gly Thr His  Trp Phe Val Thr Gln  Arg Asn Phe 
    1085                 1090                 1095             


Tyr Glu  Pro Gln Ile Ile Thr  Thr Asp Asn Thr Phe  Val Ser Gly 
    1100                 1105                 1110             


Asn Cys  Asp Val Val Ile Gly  Ile Val Asn Asn Thr  Val Tyr Asp 
    1115                 1120                 1125             


Pro Leu  Gln Ser Glu Leu Asp  Ser Ile Lys Glu Glu  Leu Asp Lys 
    1130                 1135                 1140             


Ile His  Lys Asn Gly Ser Gly  Gly Ser Gly Asp Ile  Ile Lys Leu 
    1145                 1150                 1155             


Leu Asn  Glu Gln Val Asn Lys  Glu Met Gln Ser Ser  Asn Leu Tyr 
    1160                 1165                 1170             


Met Ser  Met Ser Ser Trp Cys  Tyr Thr His Ser Leu  Asp Gly Ala 
    1175                 1180                 1185             


Gly Leu  Phe Leu Phe Asp His  Ala Ala Glu Glu Tyr  Glu His Ala 
    1190                 1195                 1200             


Lys Lys  Leu Ile Ile Phe Leu  Asn Glu Asn Asn Val  Pro Val Gln 
    1205                 1210                 1215             


Leu Thr  Ser Ile Ser Ala Pro  Glu His Lys Phe Glu  Gly Leu Thr 
    1220                 1225                 1230             


Gln Ile  Phe Gln Lys Ala Tyr  Glu His Glu Gln His  Ile Ser Glu 
    1235                 1240                 1245             


Ser Ile  Asn Asn Ile Val Asp  His Ala Ile Lys Ser  Lys Asp His 
    1250                 1255                 1260             


Ala Thr  Phe Asn Phe Leu Gln  Trp Tyr Val Ala Glu  Gln His Glu 
    1265                 1270                 1275             


Glu Glu  Val Leu Phe Lys Asp  Ile Leu Asp Lys Ile  Glu Leu Ile 
    1280                 1285                 1290             


Gly Asn  Glu Asn His Gly Leu  Tyr Leu Ala Asp Gln  Tyr Val Lys 
    1295                 1300                 1305             


Gly Ile  Ala Lys Ser Arg Lys  Ser Gly Ser 
    1310                 1315             


<210> 172
<211> 1332
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 172
Ser Ser Gln Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala 
1               5                   10                  15      


Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe 
            20                  25                  30          


Arg Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe 
        35                  40                  45              


Ser Asn Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly 
    50                  55                  60                  


Thr Lys Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr 
65                  70                  75                  80  


Phe Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly 
                85                  90                  95      


Thr Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala 
            100                 105                 110         


Thr Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro 
        115                 120                 125             


Phe Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser 
    130                 135                 140                 


Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val 
145                 150                 155                 160 


Ser Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys 
                165                 170                 175     


Asn Leu Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile 
            180                 185                 190         


Tyr Ser Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly 
        195                 200                 205             


Phe Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile 
    210                 215                 220                 


Thr Arg Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro 
225                 230                 235                 240 


Gly Asp Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val 
                245                 250                 255     


Gly Tyr Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly 
            260                 265                 270         


Thr Ile Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr 
        275                 280                 285             


Lys Cys Thr Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr 
    290                 295                 300                 


Ser Asn Phe Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn 
305                 310                 315                 320 


Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe 
                325                 330                 335     


Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala 
            340                 345                 350         


Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys 
        355                 360                 365             


Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val 
    370                 375                 380                 


Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala 
385                 390                 395                 400 


Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp 
                405                 410                 415     


Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser 
            420                 425                 430         


Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser 
        435                 440                 445             


Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala 
    450                 455                 460                 


Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro 
465                 470                 475                 480 


Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro 
                485                 490                 495     


Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr 
            500                 505                 510         


Val Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val 
        515                 520                 525             


Asn Phe Asn Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser 
    530                 535                 540                 


Asn Lys Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp 
545                 550                 555                 560 


Thr Thr Asp Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile 
                565                 570                 575     


Thr Pro Cys Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn 
            580                 585                 590         


Thr Ser Asn Gln Val Ala Val Leu Tyr Gln Gly Val Asn Cys Thr Glu 
        595                 600                 605             


Val Pro Val Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val 
    610                 615                 620                 


Tyr Ser Thr Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile 
625                 630                 635                 640 


Gly Ala Glu His Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly 
                645                 650                 655     


Ala Gly Ile Cys Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro Gly Ser 
            660                 665                 670         


Ala Ser Ser Val Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu 
        675                 680                 685             


Gly Ala Glu Asn Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro 
    690                 695                 700                 


Thr Asn Phe Thr Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met 
705                 710                 715                 720 


Thr Lys Thr Ser Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr 
                725                 730                 735     


Glu Cys Ser Asn Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu 
            740                 745                 750         


Asn Arg Ala Leu Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln 
        755                 760                 765             


Glu Val Phe Ala Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys 
    770                 775                 780                 


Asp Phe Gly Gly Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys 
785                 790                 795                 800 


Pro Ser Lys Arg Ser Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr 
                805                 810                 815     


Leu Ala Asp Ala Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp 
            820                 825                 830         


Ile Ala Ala Arg Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr 
        835                 840                 845             


Val Leu Pro Pro Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser 
    850                 855                 860                 


Ala Leu Leu Ala Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly 
865                 870                 875                 880 


Ala Ala Leu Gln Ile Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn 
                885                 890                 895     


Gly Ile Gly Val Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile 
            900                 905                 910         


Ala Asn Gln Phe Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser 
        915                 920                 925             


Ser Thr Ala Ser Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn 
    930                 935                 940                 


Ala Gln Ala Leu Asn Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly 
945                 950                 955                 960 


Ala Ile Ser Ser Val Leu Asn Asp Ile Leu Ser Arg Leu Asp Pro Pro 
                965                 970                 975     


Glu Ala Glu Val Gln Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser 
            980                 985                 990         


Leu Gln Thr Tyr Val Thr Gln Gln  Leu Ile Arg Ala Ala  Glu Ile Arg 
        995                 1000                 1005             


Ala Ser  Ala Asn Leu Ala Ala  Thr Lys Met Ser Glu  Cys Val Leu 
    1010                 1015                 1020             


Gly Gln  Ser Lys Arg Val Asp  Phe Cys Gly Lys Gly  Tyr His Leu 
    1025                 1030                 1035             


Met Ser  Phe Pro Gln Ser Ala  Pro His Gly Val Val  Phe Leu His 
    1040                 1045                 1050             


Val Thr  Tyr Val Pro Ala Gln  Glu Lys Asn Phe Thr  Thr Ala Pro 
    1055                 1060                 1065             


Ala Ile  Cys His Asp Gly Lys  Ala His Phe Pro Arg  Glu Gly Val 
    1070                 1075                 1080             


Phe Val  Ser Asn Gly Thr His  Trp Phe Val Thr Gln  Arg Asn Phe 
    1085                 1090                 1095             


Tyr Glu  Pro Gln Ile Ile Thr  Thr Asp Asn Thr Phe  Val Ser Gly 
    1100                 1105                 1110             


Asn Cys  Asp Val Val Ile Gly  Ile Val Asn Asn Thr  Val Tyr Asp 
    1115                 1120                 1125             


Pro Leu  Gln Ser Glu Leu Asp  Ser Ile Lys Glu Glu  Leu Asp Lys 
    1130                 1135                 1140             


Ile His  Lys Asn Leu Asp Ser  Ile Lys Glu Glu Leu  Asp Lys Ile 
    1145                 1150                 1155             


His Lys  Asn Gly Ser Gly Gly  Ser Gly Asp Ile Ile  Lys Leu Leu 
    1160                 1165                 1170             


Asn Glu  Gln Val Asn Lys Glu  Met Gln Ser Ser Asn  Leu Tyr Met 
    1175                 1180                 1185             


Ser Met  Ser Ser Trp Cys Tyr  Thr His Ser Leu Asp  Gly Ala Gly 
    1190                 1195                 1200             


Leu Phe  Leu Phe Asp His Ala  Ala Glu Glu Tyr Glu  His Ala Lys 
    1205                 1210                 1215             


Lys Leu  Ile Ile Phe Leu Asn  Glu Asn Asn Val Pro  Val Gln Leu 
    1220                 1225                 1230             


Thr Ser  Ile Ser Ala Pro Glu  His Lys Phe Glu Gly  Leu Thr Gln 
    1235                 1240                 1245             


Ile Phe  Gln Lys Ala Tyr Glu  His Glu Gln His Ile  Ser Glu Ser 
    1250                 1255                 1260             


Ile Asn  Asn Ile Val Asp His  Ala Ile Lys Ser Lys  Asp His Ala 
    1265                 1270                 1275             


Thr Phe  Asn Phe Leu Gln Trp  Tyr Val Ala Glu Gln  His Glu Glu 
    1280                 1285                 1290             


Glu Val  Leu Phe Lys Asp Ile  Leu Asp Lys Ile Glu  Leu Ile Gly 
    1295                 1300                 1305             


Asn Glu  Asn His Gly Leu Tyr  Leu Ala Asp Gln Tyr  Val Lys Gly 
    1310                 1315                 1320             


Ile Ala  Lys Ser Arg Lys Ser  Gly Ser 
    1325                 1330         


<210> 173
<211> 1332
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 173
Ser Ser Gln Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala 
1               5                   10                  15      


Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe 
            20                  25                  30          


Arg Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe 
        35                  40                  45              


Ser Asn Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly 
    50                  55                  60                  


Thr Lys Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr 
65                  70                  75                  80  


Phe Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly 
                85                  90                  95      


Thr Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala 
            100                 105                 110         


Thr Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro 
        115                 120                 125             


Phe Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser 
    130                 135                 140                 


Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val 
145                 150                 155                 160 


Ser Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys 
                165                 170                 175     


Asn Leu Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile 
            180                 185                 190         


Tyr Ser Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly 
        195                 200                 205             


Phe Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile 
    210                 215                 220                 


Thr Arg Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro 
225                 230                 235                 240 


Gly Asp Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val 
                245                 250                 255     


Gly Tyr Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly 
            260                 265                 270         


Thr Ile Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr 
        275                 280                 285             


Lys Cys Thr Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr 
    290                 295                 300                 


Ser Asn Phe Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn 
305                 310                 315                 320 


Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe 
                325                 330                 335     


Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala 
            340                 345                 350         


Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys 
        355                 360                 365             


Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val 
    370                 375                 380                 


Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala 
385                 390                 395                 400 


Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp 
                405                 410                 415     


Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser 
            420                 425                 430         


Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser 
        435                 440                 445             


Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala 
    450                 455                 460                 


Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro 
465                 470                 475                 480 


Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro 
                485                 490                 495     


Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr 
            500                 505                 510         


Val Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val 
        515                 520                 525             


Asn Phe Asn Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser 
    530                 535                 540                 


Asn Lys Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp 
545                 550                 555                 560 


Thr Thr Asp Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile 
                565                 570                 575     


Thr Pro Cys Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn 
            580                 585                 590         


Thr Ser Asn Gln Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu 
        595                 600                 605             


Val Pro Val Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val 
    610                 615                 620                 


Tyr Ser Thr Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile 
625                 630                 635                 640 


Gly Ala Glu His Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly 
                645                 650                 655     


Ala Gly Ile Cys Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro Gly Ser 
            660                 665                 670         


Ala Ser Ser Val Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu 
        675                 680                 685             


Gly Ala Glu Asn Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro 
    690                 695                 700                 


Thr Asn Phe Thr Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met 
705                 710                 715                 720 


Thr Lys Thr Ser Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr 
                725                 730                 735     


Glu Cys Ser Asn Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu 
            740                 745                 750         


Asn Arg Ala Leu Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln 
        755                 760                 765             


Glu Val Phe Ala Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys 
    770                 775                 780                 


Asp Phe Gly Gly Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys 
785                 790                 795                 800 


Pro Ser Lys Arg Ser Pro Ile Glu Asp Leu Leu Phe Asn Lys Val Thr 
                805                 810                 815     


Leu Ala Asp Ala Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp 
            820                 825                 830         


Ile Ala Ala Arg Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr 
        835                 840                 845             


Val Leu Pro Pro Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser 
    850                 855                 860                 


Ala Leu Leu Ala Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly 
865                 870                 875                 880 


Pro Ala Leu Gln Ile Pro Phe Pro Met Gln Met Ala Tyr Arg Phe Asn 
                885                 890                 895     


Gly Ile Gly Val Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile 
            900                 905                 910         


Ala Asn Gln Phe Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser 
        915                 920                 925             


Ser Thr Pro Ser Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn 
    930                 935                 940                 


Ala Gln Ala Leu Asn Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly 
945                 950                 955                 960 


Ala Ile Ser Ser Val Leu Asn Asp Ile Leu Ser Arg Leu Asp Pro Pro 
                965                 970                 975     


Glu Ala Glu Val Gln Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser 
            980                 985                 990         


Leu Gln Thr Tyr Val Thr Gln Gln  Leu Ile Arg Ala Ala  Glu Ile Arg 
        995                 1000                 1005             


Ala Ser  Ala Asn Leu Ala Ala  Thr Lys Met Ser Glu  Cys Val Leu 
    1010                 1015                 1020             


Gly Gln  Ser Lys Arg Val Asp  Phe Cys Gly Lys Gly  Tyr His Leu 
    1025                 1030                 1035             


Met Ser  Phe Pro Gln Ser Ala  Pro His Gly Val Val  Phe Leu His 
    1040                 1045                 1050             


Val Thr  Tyr Val Pro Ala Gln  Glu Lys Asn Phe Thr  Thr Ala Pro 
    1055                 1060                 1065             


Ala Ile  Cys His Asp Gly Lys  Ala His Phe Pro Arg  Glu Gly Val 
    1070                 1075                 1080             


Phe Val  Ser Asn Gly Thr His  Trp Phe Val Thr Gln  Arg Asn Phe 
    1085                 1090                 1095             


Tyr Glu  Pro Gln Ile Ile Thr  Thr Asp Asn Thr Phe  Val Ser Gly 
    1100                 1105                 1110             


Asn Cys  Asp Val Val Ile Gly  Ile Val Asn Asn Thr  Val Tyr Asp 
    1115                 1120                 1125             


Pro Leu  Gln Ser Glu Leu Asp  Ser Ile Lys Glu Glu  Leu Asp Lys 
    1130                 1135                 1140             


Ile His  Lys Asn Leu Asp Ser  Ile Lys Glu Glu Leu  Asp Lys Ile 
    1145                 1150                 1155             


His Lys  Asn Gly Ser Gly Gly  Ser Gly Asp Ile Ile  Lys Leu Leu 
    1160                 1165                 1170             


Asn Glu  Gln Val Asn Lys Glu  Met Gln Ser Ser Asn  Leu Tyr Met 
    1175                 1180                 1185             


Ser Met  Ser Ser Trp Cys Tyr  Thr His Ser Leu Asp  Gly Ala Gly 
    1190                 1195                 1200             


Leu Phe  Leu Phe Asp His Ala  Ala Glu Glu Tyr Glu  His Ala Lys 
    1205                 1210                 1215             


Lys Leu  Ile Ile Phe Leu Asn  Glu Asn Asn Val Pro  Val Gln Leu 
    1220                 1225                 1230             


Thr Ser  Ile Ser Ala Pro Glu  His Lys Phe Glu Gly  Leu Thr Gln 
    1235                 1240                 1245             


Ile Phe  Gln Lys Ala Tyr Glu  His Glu Gln His Ile  Ser Glu Ser 
    1250                 1255                 1260             


Ile Asn  Asn Ile Val Asp His  Ala Ile Lys Ser Lys  Asp His Ala 
    1265                 1270                 1275             


Thr Phe  Asn Phe Leu Gln Trp  Tyr Val Ala Glu Gln  His Glu Glu 
    1280                 1285                 1290             


Glu Val  Leu Phe Lys Asp Ile  Leu Asp Lys Ile Glu  Leu Ile Gly 
    1295                 1300                 1305             


Asn Glu  Asn His Gly Leu Tyr  Leu Ala Asp Gln Tyr  Val Lys Gly 
    1310                 1315                 1320             


Ile Ala  Lys Ser Arg Lys Ser  Gly Ser 
    1325                 1330         


<210> 174
<211> 1332
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 174
Ser Ser Gln Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala 
1               5                   10                  15      


Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe 
            20                  25                  30          


Arg Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe 
        35                  40                  45              


Ser Asn Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly 
    50                  55                  60                  


Thr Lys Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr 
65                  70                  75                  80  


Phe Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly 
                85                  90                  95      


Thr Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala 
            100                 105                 110         


Thr Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro 
        115                 120                 125             


Phe Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser 
    130                 135                 140                 


Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val 
145                 150                 155                 160 


Ser Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys 
                165                 170                 175     


Asn Leu Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile 
            180                 185                 190         


Tyr Ser Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly 
        195                 200                 205             


Phe Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile 
    210                 215                 220                 


Thr Arg Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro 
225                 230                 235                 240 


Gly Asp Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val 
                245                 250                 255     


Gly Tyr Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly 
            260                 265                 270         


Thr Ile Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr 
        275                 280                 285             


Lys Cys Thr Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr 
    290                 295                 300                 


Ser Asn Phe Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn 
305                 310                 315                 320 


Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe 
                325                 330                 335     


Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala 
            340                 345                 350         


Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys 
        355                 360                 365             


Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val 
    370                 375                 380                 


Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala 
385                 390                 395                 400 


Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp 
                405                 410                 415     


Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser 
            420                 425                 430         


Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser 
        435                 440                 445             


Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala 
    450                 455                 460                 


Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro 
465                 470                 475                 480 


Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro 
                485                 490                 495     


Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr 
            500                 505                 510         


Val Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val 
        515                 520                 525             


Asn Phe Asn Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser 
    530                 535                 540                 


Asn Lys Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp 
545                 550                 555                 560 


Thr Thr Asp Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile 
                565                 570                 575     


Thr Pro Cys Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn 
            580                 585                 590         


Thr Ser Asn Gln Val Ala Val Leu Tyr Gln Gly Val Asn Cys Thr Glu 
        595                 600                 605             


Val Pro Val Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val 
    610                 615                 620                 


Tyr Ser Thr Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile 
625                 630                 635                 640 


Gly Ala Glu His Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly 
                645                 650                 655     


Ala Gly Ile Cys Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro Gly Ser 
            660                 665                 670         


Ala Ser Ser Val Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu 
        675                 680                 685             


Gly Ala Glu Asn Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro 
    690                 695                 700                 


Thr Asn Phe Thr Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met 
705                 710                 715                 720 


Thr Lys Thr Ser Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr 
                725                 730                 735     


Glu Cys Ser Asn Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu 
            740                 745                 750         


Asn Arg Ala Leu Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln 
        755                 760                 765             


Glu Val Phe Ala Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys 
    770                 775                 780                 


Asp Phe Gly Gly Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys 
785                 790                 795                 800 


Pro Ser Lys Arg Ser Pro Ile Glu Asp Leu Leu Phe Asn Lys Val Thr 
                805                 810                 815     


Leu Ala Asp Ala Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp 
            820                 825                 830         


Ile Ala Ala Arg Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr 
        835                 840                 845             


Val Leu Pro Pro Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser 
    850                 855                 860                 


Ala Leu Leu Ala Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly 
865                 870                 875                 880 


Pro Ala Leu Gln Ile Pro Phe Pro Met Gln Met Ala Tyr Arg Phe Asn 
                885                 890                 895     


Gly Ile Gly Val Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile 
            900                 905                 910         


Ala Asn Gln Phe Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser 
        915                 920                 925             


Ser Thr Pro Ser Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn 
    930                 935                 940                 


Ala Gln Ala Leu Asn Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly 
945                 950                 955                 960 


Ala Ile Ser Ser Val Leu Asn Asp Ile Leu Ser Arg Leu Asp Pro Pro 
                965                 970                 975     


Glu Ala Glu Val Gln Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser 
            980                 985                 990         


Leu Gln Thr Tyr Val Thr Gln Gln  Leu Ile Arg Ala Ala  Glu Ile Arg 
        995                 1000                 1005             


Ala Ser  Ala Asn Leu Ala Ala  Thr Lys Met Ser Glu  Cys Val Leu 
    1010                 1015                 1020             


Gly Gln  Ser Lys Arg Val Asp  Phe Cys Gly Lys Gly  Tyr His Leu 
    1025                 1030                 1035             


Met Ser  Phe Pro Gln Ser Ala  Pro His Gly Val Val  Phe Leu His 
    1040                 1045                 1050             


Val Thr  Tyr Val Pro Ala Gln  Glu Lys Asn Phe Thr  Thr Ala Pro 
    1055                 1060                 1065             


Ala Ile  Cys His Asp Gly Lys  Ala His Phe Pro Arg  Glu Gly Val 
    1070                 1075                 1080             


Phe Val  Ser Asn Gly Thr His  Trp Phe Val Thr Gln  Arg Asn Phe 
    1085                 1090                 1095             


Tyr Glu  Pro Gln Ile Ile Thr  Thr Asp Asn Thr Phe  Val Ser Gly 
    1100                 1105                 1110             


Asn Cys  Asp Val Val Ile Gly  Ile Val Asn Asn Thr  Val Tyr Asp 
    1115                 1120                 1125             


Pro Leu  Gln Ser Glu Leu Asp  Ser Ile Lys Glu Glu  Leu Asp Lys 
    1130                 1135                 1140             


Ile His  Lys Asn Leu Asp Ser  Ile Lys Glu Glu Leu  Asp Lys Ile 
    1145                 1150                 1155             


His Lys  Asn Gly Ser Gly Gly  Ser Gly Asp Ile Ile  Lys Leu Leu 
    1160                 1165                 1170             


Asn Glu  Gln Val Asn Lys Glu  Met Gln Ser Ser Asn  Leu Tyr Met 
    1175                 1180                 1185             


Ser Met  Ser Ser Trp Cys Tyr  Thr His Ser Leu Asp  Gly Ala Gly 
    1190                 1195                 1200             


Leu Phe  Leu Phe Asp His Ala  Ala Glu Glu Tyr Glu  His Ala Lys 
    1205                 1210                 1215             


Lys Leu  Ile Ile Phe Leu Asn  Glu Asn Asn Val Pro  Val Gln Leu 
    1220                 1225                 1230             


Thr Ser  Ile Ser Ala Pro Glu  His Lys Phe Glu Gly  Leu Thr Gln 
    1235                 1240                 1245             


Ile Phe  Gln Lys Ala Tyr Glu  His Glu Gln His Ile  Ser Glu Ser 
    1250                 1255                 1260             


Ile Asn  Asn Ile Val Asp His  Ala Ile Lys Ser Lys  Asp His Ala 
    1265                 1270                 1275             


Thr Phe  Asn Phe Leu Gln Trp  Tyr Val Ala Glu Gln  His Glu Glu 
    1280                 1285                 1290             


Glu Val  Leu Phe Lys Asp Ile  Leu Asp Lys Ile Glu  Leu Ile Gly 
    1295                 1300                 1305             


Asn Glu  Asn His Gly Leu Tyr  Leu Ala Asp Gln Tyr  Val Lys Gly 
    1310                 1315                 1320             


Ile Ala  Lys Ser Arg Lys Ser  Gly Ser 
    1325                 1330         


<210> 175
<211> 1310
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 175
Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser 
1               5                   10                  15      


Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val 
            20                  25                  30          


Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr 
        35                  40                  45              


Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe 
    50                  55                  60                  


Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr 
65                  70                  75                  80  


Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp 
                85                  90                  95      


Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val 
            100                 105                 110         


Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val 
        115                 120                 125             


Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val 
    130                 135                 140                 


Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe 
145                 150                 155                 160 


Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu 
                165                 170                 175     


Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His 
            180                 185                 190         


Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu 
        195                 200                 205             


Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln 
    210                 215                 220                 


Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser 
225                 230                 235                 240 


Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln 
                245                 250                 255     


Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp 
            260                 265                 270         


Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu 
        275                 280                 285             


Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg 
    290                 295                 300                 


Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu 
305                 310                 315                 320 


Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr 
                325                 330                 335     


Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val 
            340                 345                 350         


Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser 
        355                 360                 365             


Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser 
    370                 375                 380                 


Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr 
385                 390                 395                 400 


Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly 
                405                 410                 415     


Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly 
            420                 425                 430         


Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro 
        435                 440                 445             


Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro 
    450                 455                 460                 


Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr 
465                 470                 475                 480 


Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val 
                485                 490                 495     


Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro 
            500                 505                 510         


Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe 
        515                 520                 525             


Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe 
    530                 535                 540                 


Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala 
545                 550                 555                 560 


Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser 
                565                 570                 575     


Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln 
            580                 585                 590         


Val Ala Val Leu Tyr Gln Gly Val Asn Cys Thr Glu Val Pro Val Ala 
        595                 600                 605             


Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly 
    610                 615                 620                 


Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His 
625                 630                 635                 640 


Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys 
                645                 650                 655     


Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro Gly Ser Ala Ser Ser Val 
            660                 665                 670         


Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn 
        675                 680                 685             


Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr 
    690                 695                 700                 


Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser 
705                 710                 715                 720 


Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn 
                725                 730                 735     


Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu 
            740                 745                 750         


Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala 
        755                 760                 765             


Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly 
    770                 775                 780                 


Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg 
785                 790                 795                 800 


Ser Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala 
                805                 810                 815     


Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg 
            820                 825                 830         


Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro 
        835                 840                 845             


Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala 
    850                 855                 860                 


Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln 
865                 870                 875                 880 


Ile Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val 
                885                 890                 895     


Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe 
            900                 905                 910         


Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser 
        915                 920                 925             


Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu 
    930                 935                 940                 


Asn Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser 
945                 950                 955                 960 


Val Leu Asn Asp Ile Leu Ser Arg Leu Asp Pro Pro Glu Ala Glu Val 
                965                 970                 975     


Gln Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser Leu Gln Thr Tyr 
            980                 985                 990         


Val Thr Gln Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
        995                 1000                 1005             


Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1010                 1015                 1020             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1025                 1030                 1035             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1040                 1045                 1050             


Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1055                 1060                 1065             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1070                 1075                 1080             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1085                 1090                 1095             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1100                 1105                 1110             


Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro 
    1115                 1120                 1125             


Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Gly  Ser Gly Gly 
    1130                 1135                 1140             


Ser Gly  Asp Ile Ile Lys Leu  Leu Asn Glu Gln Val  Asn Lys Glu 
    1145                 1150                 1155             


Met Gln  Ser Ser Asn Leu Tyr  Met Ser Met Ser Ser  Trp Cys Tyr 
    1160                 1165                 1170             


Thr His  Ser Leu Asp Gly Ala  Gly Leu Phe Leu Phe  Asp His Ala 
    1175                 1180                 1185             


Ala Glu  Glu Tyr Glu His Ala  Lys Lys Leu Ile Ile  Phe Leu Asn 
    1190                 1195                 1200             


Glu Asn  Asn Val Pro Val Gln  Leu Thr Ser Ile Ser  Ala Pro Glu 
    1205                 1210                 1215             


His Lys  Phe Glu Gly Leu Thr  Gln Ile Phe Gln Lys  Ala Tyr Glu 
    1220                 1225                 1230             


His Glu  Gln His Ile Ser Glu  Ser Ile Asn Asn Ile  Val Asp His 
    1235                 1240                 1245             


Ala Ile  Lys Ser Lys Asp His  Ala Thr Phe Asn Phe  Leu Gln Trp 
    1250                 1255                 1260             


Tyr Val  Ala Glu Gln His Glu  Glu Glu Val Leu Phe  Lys Asp Ile 
    1265                 1270                 1275             


Leu Asp  Lys Ile Glu Leu Ile  Gly Asn Glu Asn His  Gly Leu Tyr 
    1280                 1285                 1290             


Leu Ala  Asp Gln Tyr Val Lys  Gly Ile Ala Lys Ser  Arg Lys Ser 
    1295                 1300                 1305             


Gly Ser  
    1310 


<210> 176
<211> 1318
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 176
Ser Ser Gln Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala 
1               5                   10                  15      


Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe 
            20                  25                  30          


Arg Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe 
        35                  40                  45              


Ser Asn Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly 
    50                  55                  60                  


Thr Lys Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr 
65                  70                  75                  80  


Phe Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly 
                85                  90                  95      


Thr Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala 
            100                 105                 110         


Thr Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro 
        115                 120                 125             


Phe Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser 
    130                 135                 140                 


Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val 
145                 150                 155                 160 


Ser Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys 
                165                 170                 175     


Asn Leu Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile 
            180                 185                 190         


Tyr Ser Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly 
        195                 200                 205             


Phe Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile 
    210                 215                 220                 


Thr Arg Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro 
225                 230                 235                 240 


Gly Asp Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val 
                245                 250                 255     


Gly Tyr Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly 
            260                 265                 270         


Thr Ile Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr 
        275                 280                 285             


Lys Cys Thr Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr 
    290                 295                 300                 


Ser Asn Phe Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn 
305                 310                 315                 320 


Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe 
                325                 330                 335     


Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala 
            340                 345                 350         


Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys 
        355                 360                 365             


Tyr Gly Val Cys Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val 
    370                 375                 380                 


Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala 
385                 390                 395                 400 


Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp 
                405                 410                 415     


Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser 
            420                 425                 430         


Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser 
        435                 440                 445             


Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala 
    450                 455                 460                 


Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro 
465                 470                 475                 480 


Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro 
                485                 490                 495     


Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr 
            500                 505                 510         


Val Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val 
        515                 520                 525             


Asn Phe Asn Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser 
    530                 535                 540                 


Asn Lys Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp 
545                 550                 555                 560 


Thr Thr Asp Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile 
                565                 570                 575     


Thr Pro Cys Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn 
            580                 585                 590         


Thr Ser Asn Gln Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu 
        595                 600                 605             


Val Pro Val Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val 
    610                 615                 620                 


Tyr Ser Thr Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile 
625                 630                 635                 640 


Gly Ala Glu His Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly 
                645                 650                 655     


Ala Gly Ile Cys Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro Gly Ser 
            660                 665                 670         


Ala Ser Ser Val Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu 
        675                 680                 685             


Gly Ala Glu Asn Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro 
    690                 695                 700                 


Thr Asn Phe Thr Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met 
705                 710                 715                 720 


Thr Lys Thr Ser Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr 
                725                 730                 735     


Glu Cys Ser Asn Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu 
            740                 745                 750         


Asn Arg Ala Leu Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln 
        755                 760                 765             


Glu Val Phe Ala Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys 
    770                 775                 780                 


Asp Phe Gly Gly Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys 
785                 790                 795                 800 


Pro Ser Lys Arg Ser Pro Ile Glu Asp Leu Leu Phe Asn Lys Val Thr 
                805                 810                 815     


Leu Ala Asp Ala Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp 
            820                 825                 830         


Ile Ala Ala Arg Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr 
        835                 840                 845             


Val Leu Pro Pro Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser 
    850                 855                 860                 


Ala Leu Leu Ala Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly 
865                 870                 875                 880 


Pro Ala Leu Gln Ile Pro Phe Pro Met Gln Met Ala Tyr Arg Phe Asn 
                885                 890                 895     


Gly Ile Gly Val Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile 
            900                 905                 910         


Ala Asn Gln Phe Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser 
        915                 920                 925             


Ser Thr Pro Ser Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn 
    930                 935                 940                 


Ala Gln Ala Leu Asn Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly 
945                 950                 955                 960 


Ala Ile Ser Ser Val Leu Asn Asp Ile Leu Ser Arg Leu Cys Pro Pro 
                965                 970                 975     


Glu Ala Glu Val Gln Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser 
            980                 985                 990         


Leu Gln Thr Tyr Val Thr Gln Gln  Leu Ile Arg Ala Ala  Glu Ile Arg 
        995                 1000                 1005             


Ala Ser  Ala Asn Leu Ala Ala  Thr Lys Met Ser Glu  Cys Val Leu 
    1010                 1015                 1020             


Gly Gln  Ser Lys Arg Val Asp  Phe Cys Gly Lys Gly  Tyr His Leu 
    1025                 1030                 1035             


Met Ser  Phe Pro Gln Ser Ala  Pro His Gly Val Val  Phe Leu His 
    1040                 1045                 1050             


Val Thr  Tyr Val Pro Ala Gln  Glu Lys Asn Phe Thr  Thr Ala Pro 
    1055                 1060                 1065             


Ala Ile  Cys His Asp Gly Lys  Ala His Phe Pro Arg  Glu Gly Val 
    1070                 1075                 1080             


Phe Val  Ser Asn Gly Thr His  Trp Phe Val Thr Gln  Arg Asn Phe 
    1085                 1090                 1095             


Tyr Glu  Pro Gln Ile Ile Thr  Thr Asp Asn Thr Phe  Val Ser Gly 
    1100                 1105                 1110             


Asn Cys  Asp Val Val Ile Gly  Ile Val Asn Asn Thr  Val Tyr Asp 
    1115                 1120                 1125             


Pro Leu  Gln Ser Glu Leu Asp  Ser Ile Lys Glu Glu  Leu Asp Lys 
    1130                 1135                 1140             


Ile His  Lys Asn Gly Ser Gly  Gly Ser Gly Asp Ile  Ile Lys Leu 
    1145                 1150                 1155             


Leu Asn  Glu Gln Val Asn Lys  Glu Met Gln Ser Ser  Asn Leu Tyr 
    1160                 1165                 1170             


Met Ser  Met Ser Ser Trp Cys  Tyr Thr His Ser Leu  Asp Gly Ala 
    1175                 1180                 1185             


Gly Leu  Phe Leu Phe Asp His  Ala Ala Glu Glu Tyr  Glu His Ala 
    1190                 1195                 1200             


Lys Lys  Leu Ile Ile Phe Leu  Asn Glu Asn Asn Val  Pro Val Gln 
    1205                 1210                 1215             


Leu Thr  Ser Ile Ser Ala Pro  Glu His Lys Phe Glu  Gly Leu Thr 
    1220                 1225                 1230             


Gln Ile  Phe Gln Lys Ala Tyr  Glu His Glu Gln His  Ile Ser Glu 
    1235                 1240                 1245             


Ser Ile  Asn Asn Ile Val Asp  His Ala Ile Lys Ser  Lys Asp His 
    1250                 1255                 1260             


Ala Thr  Phe Asn Phe Leu Gln  Trp Tyr Val Ala Glu  Gln His Glu 
    1265                 1270                 1275             


Glu Glu  Val Leu Phe Lys Asp  Ile Leu Asp Lys Ile  Glu Leu Ile 
    1280                 1285                 1290             


Gly Asn  Glu Asn His Gly Leu  Tyr Leu Ala Asp Gln  Tyr Val Lys 
    1295                 1300                 1305             


Gly Ile  Ala Lys Ser Arg Lys  Ser Gly Ser 
    1310                 1315             


<210> 177
<211> 1318
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 177
Ser Ser Gln Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala 
1               5                   10                  15      


Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe 
            20                  25                  30          


Arg Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe 
        35                  40                  45              


Ser Asn Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly 
    50                  55                  60                  


Thr Lys Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr 
65                  70                  75                  80  


Phe Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly 
                85                  90                  95      


Thr Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala 
            100                 105                 110         


Thr Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro 
        115                 120                 125             


Phe Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser 
    130                 135                 140                 


Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val 
145                 150                 155                 160 


Ser Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys 
                165                 170                 175     


Asn Leu Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile 
            180                 185                 190         


Tyr Ser Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly 
        195                 200                 205             


Phe Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile 
    210                 215                 220                 


Thr Arg Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro 
225                 230                 235                 240 


Gly Asp Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val 
                245                 250                 255     


Gly Tyr Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly 
            260                 265                 270         


Thr Ile Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr 
        275                 280                 285             


Lys Cys Thr Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr 
    290                 295                 300                 


Ser Asn Phe Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn 
305                 310                 315                 320 


Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe 
                325                 330                 335     


Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala 
            340                 345                 350         


Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys 
        355                 360                 365             


Tyr Gly Val Cys Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val 
    370                 375                 380                 


Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala 
385                 390                 395                 400 


Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp 
                405                 410                 415     


Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser 
            420                 425                 430         


Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser 
        435                 440                 445             


Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala 
    450                 455                 460                 


Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro 
465                 470                 475                 480 


Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro 
                485                 490                 495     


Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr 
            500                 505                 510         


Val Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val 
        515                 520                 525             


Asn Phe Asn Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser 
    530                 535                 540                 


Asn Lys Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp 
545                 550                 555                 560 


Thr Thr Asp Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile 
                565                 570                 575     


Thr Pro Cys Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn 
            580                 585                 590         


Thr Ser Asn Gln Val Ala Val Leu Tyr Gln Gly Val Asn Cys Thr Glu 
        595                 600                 605             


Val Pro Val Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val 
    610                 615                 620                 


Tyr Ser Thr Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile 
625                 630                 635                 640 


Gly Ala Glu His Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly 
                645                 650                 655     


Ala Gly Ile Cys Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro Gly Ser 
            660                 665                 670         


Ala Ser Ser Val Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu 
        675                 680                 685             


Gly Ala Glu Asn Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro 
    690                 695                 700                 


Thr Asn Phe Thr Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met 
705                 710                 715                 720 


Thr Lys Thr Ser Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr 
                725                 730                 735     


Glu Cys Ser Asn Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu 
            740                 745                 750         


Asn Arg Ala Leu Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln 
        755                 760                 765             


Glu Val Phe Ala Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys 
    770                 775                 780                 


Asp Phe Gly Gly Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys 
785                 790                 795                 800 


Pro Ser Lys Arg Ser Pro Ile Glu Asp Leu Leu Phe Asn Lys Val Thr 
                805                 810                 815     


Leu Ala Asp Ala Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp 
            820                 825                 830         


Ile Ala Ala Arg Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr 
        835                 840                 845             


Val Leu Pro Pro Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser 
    850                 855                 860                 


Ala Leu Leu Ala Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly 
865                 870                 875                 880 


Pro Ala Leu Gln Ile Pro Phe Pro Met Gln Met Ala Tyr Arg Phe Asn 
                885                 890                 895     


Gly Ile Gly Val Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile 
            900                 905                 910         


Ala Asn Gln Phe Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser 
        915                 920                 925             


Ser Thr Pro Ser Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn 
    930                 935                 940                 


Ala Gln Ala Leu Asn Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly 
945                 950                 955                 960 


Ala Ile Ser Ser Val Leu Asn Asp Ile Leu Ser Arg Leu Cys Pro Pro 
                965                 970                 975     


Glu Ala Glu Val Gln Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser 
            980                 985                 990         


Leu Gln Thr Tyr Val Thr Gln Gln  Leu Ile Arg Ala Ala  Glu Ile Arg 
        995                 1000                 1005             


Ala Ser  Ala Asn Leu Ala Ala  Thr Lys Met Ser Glu  Cys Val Leu 
    1010                 1015                 1020             


Gly Gln  Ser Lys Arg Val Asp  Phe Cys Gly Lys Gly  Tyr His Leu 
    1025                 1030                 1035             


Met Ser  Phe Pro Gln Ser Ala  Pro His Gly Val Val  Phe Leu His 
    1040                 1045                 1050             


Val Thr  Tyr Val Pro Ala Gln  Glu Lys Asn Phe Thr  Thr Ala Pro 
    1055                 1060                 1065             


Ala Ile  Cys His Asp Gly Lys  Ala His Phe Pro Arg  Glu Gly Val 
    1070                 1075                 1080             


Phe Val  Ser Asn Gly Thr His  Trp Phe Val Thr Gln  Arg Asn Phe 
    1085                 1090                 1095             


Tyr Glu  Pro Gln Ile Ile Thr  Thr Asp Asn Thr Phe  Val Ser Gly 
    1100                 1105                 1110             


Asn Cys  Asp Val Val Ile Gly  Ile Val Asn Asn Thr  Val Tyr Asp 
    1115                 1120                 1125             


Pro Leu  Gln Ser Glu Leu Asp  Ser Ile Lys Glu Glu  Leu Asp Lys 
    1130                 1135                 1140             


Ile His  Lys Asn Gly Ser Gly  Gly Ser Gly Asp Ile  Ile Lys Leu 
    1145                 1150                 1155             


Leu Asn  Glu Gln Val Asn Lys  Glu Met Gln Ser Ser  Asn Leu Tyr 
    1160                 1165                 1170             


Met Ser  Met Ser Ser Trp Cys  Tyr Thr His Ser Leu  Asp Gly Ala 
    1175                 1180                 1185             


Gly Leu  Phe Leu Phe Asp His  Ala Ala Glu Glu Tyr  Glu His Ala 
    1190                 1195                 1200             


Lys Lys  Leu Ile Ile Phe Leu  Asn Glu Asn Asn Val  Pro Val Gln 
    1205                 1210                 1215             


Leu Thr  Ser Ile Ser Ala Pro  Glu His Lys Phe Glu  Gly Leu Thr 
    1220                 1225                 1230             


Gln Ile  Phe Gln Lys Ala Tyr  Glu His Glu Gln His  Ile Ser Glu 
    1235                 1240                 1245             


Ser Ile  Asn Asn Ile Val Asp  His Ala Ile Lys Ser  Lys Asp His 
    1250                 1255                 1260             


Ala Thr  Phe Asn Phe Leu Gln  Trp Tyr Val Ala Glu  Gln His Glu 
    1265                 1270                 1275             


Glu Glu  Val Leu Phe Lys Asp  Ile Leu Asp Lys Ile  Glu Leu Ile 
    1280                 1285                 1290             


Gly Asn  Glu Asn His Gly Leu  Tyr Leu Ala Asp Gln  Tyr Val Lys 
    1295                 1300                 1305             


Gly Ile  Ala Lys Ser Arg Lys  Ser Gly Ser 
    1310                 1315             


<210> 178
<211> 1332
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 178
Ser Ser Gln Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala 
1               5                   10                  15      


Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe 
            20                  25                  30          


Arg Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe 
        35                  40                  45              


Ser Asn Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly 
    50                  55                  60                  


Thr Lys Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr 
65                  70                  75                  80  


Phe Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly 
                85                  90                  95      


Thr Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala 
            100                 105                 110         


Thr Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro 
        115                 120                 125             


Phe Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser 
    130                 135                 140                 


Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val 
145                 150                 155                 160 


Ser Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys 
                165                 170                 175     


Asn Leu Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile 
            180                 185                 190         


Tyr Ser Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly 
        195                 200                 205             


Phe Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile 
    210                 215                 220                 


Thr Arg Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro 
225                 230                 235                 240 


Gly Asp Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val 
                245                 250                 255     


Gly Tyr Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly 
            260                 265                 270         


Thr Ile Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr 
        275                 280                 285             


Lys Cys Thr Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr 
    290                 295                 300                 


Ser Asn Phe Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn 
305                 310                 315                 320 


Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe 
                325                 330                 335     


Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala 
            340                 345                 350         


Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys 
        355                 360                 365             


Tyr Gly Val Cys Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val 
    370                 375                 380                 


Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala 
385                 390                 395                 400 


Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp 
                405                 410                 415     


Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser 
            420                 425                 430         


Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser 
        435                 440                 445             


Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala 
    450                 455                 460                 


Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro 
465                 470                 475                 480 


Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro 
                485                 490                 495     


Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr 
            500                 505                 510         


Val Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val 
        515                 520                 525             


Asn Phe Asn Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser 
    530                 535                 540                 


Asn Lys Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp 
545                 550                 555                 560 


Thr Thr Asp Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile 
                565                 570                 575     


Thr Pro Cys Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn 
            580                 585                 590         


Thr Ser Asn Gln Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu 
        595                 600                 605             


Val Pro Val Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val 
    610                 615                 620                 


Tyr Ser Thr Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile 
625                 630                 635                 640 


Gly Ala Glu His Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly 
                645                 650                 655     


Ala Gly Ile Cys Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro Gly Ser 
            660                 665                 670         


Ala Ser Ser Val Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu 
        675                 680                 685             


Gly Ala Glu Asn Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro 
    690                 695                 700                 


Thr Asn Phe Thr Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met 
705                 710                 715                 720 


Thr Lys Thr Ser Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr 
                725                 730                 735     


Glu Cys Ser Asn Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu 
            740                 745                 750         


Asn Arg Ala Leu Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln 
        755                 760                 765             


Glu Val Phe Ala Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys 
    770                 775                 780                 


Asp Phe Gly Gly Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys 
785                 790                 795                 800 


Pro Ser Lys Arg Ser Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr 
                805                 810                 815     


Leu Ala Asp Ala Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp 
            820                 825                 830         


Ile Ala Ala Arg Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr 
        835                 840                 845             


Val Leu Pro Pro Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser 
    850                 855                 860                 


Ala Leu Leu Ala Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly 
865                 870                 875                 880 


Ala Ala Leu Gln Ile Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn 
                885                 890                 895     


Gly Ile Gly Val Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile 
            900                 905                 910         


Ala Asn Gln Phe Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser 
        915                 920                 925             


Ser Thr Ala Ser Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn 
    930                 935                 940                 


Ala Gln Ala Leu Asn Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly 
945                 950                 955                 960 


Ala Ile Ser Ser Val Leu Asn Asp Ile Leu Ser Arg Leu Cys Pro Pro 
                965                 970                 975     


Glu Ala Glu Val Gln Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser 
            980                 985                 990         


Leu Gln Thr Tyr Val Thr Gln Gln  Leu Ile Arg Ala Ala  Glu Ile Arg 
        995                 1000                 1005             


Ala Ser  Ala Asn Leu Ala Ala  Thr Lys Met Ser Glu  Cys Val Leu 
    1010                 1015                 1020             


Gly Gln  Ser Lys Arg Val Asp  Phe Cys Gly Lys Gly  Tyr His Leu 
    1025                 1030                 1035             


Met Ser  Phe Pro Gln Ser Ala  Pro His Gly Val Val  Phe Leu His 
    1040                 1045                 1050             


Val Thr  Tyr Val Pro Ala Gln  Glu Lys Asn Phe Thr  Thr Ala Pro 
    1055                 1060                 1065             


Ala Ile  Cys His Asp Gly Lys  Ala His Phe Pro Arg  Glu Gly Val 
    1070                 1075                 1080             


Phe Val  Ser Asn Gly Thr His  Trp Phe Val Thr Gln  Arg Asn Phe 
    1085                 1090                 1095             


Tyr Glu  Pro Gln Ile Ile Thr  Thr Asp Asn Thr Phe  Val Ser Gly 
    1100                 1105                 1110             


Asn Cys  Asp Val Val Ile Gly  Ile Val Asn Asn Thr  Val Tyr Asp 
    1115                 1120                 1125             


Pro Leu  Gln Ser Glu Leu Asp  Ser Ile Lys Glu Glu  Leu Asp Lys 
    1130                 1135                 1140             


Ile His  Lys Asn Leu Asp Ser  Ile Lys Glu Glu Leu  Asp Lys Ile 
    1145                 1150                 1155             


His Lys  Asn Gly Ser Gly Gly  Ser Gly Asp Ile Ile  Lys Leu Leu 
    1160                 1165                 1170             


Asn Glu  Gln Val Asn Lys Glu  Met Gln Ser Ser Asn  Leu Tyr Met 
    1175                 1180                 1185             


Ser Met  Ser Ser Trp Cys Tyr  Thr His Ser Leu Asp  Gly Ala Gly 
    1190                 1195                 1200             


Leu Phe  Leu Phe Asp His Ala  Ala Glu Glu Tyr Glu  His Ala Lys 
    1205                 1210                 1215             


Lys Leu  Ile Ile Phe Leu Asn  Glu Asn Asn Val Pro  Val Gln Leu 
    1220                 1225                 1230             


Thr Ser  Ile Ser Ala Pro Glu  His Lys Phe Glu Gly  Leu Thr Gln 
    1235                 1240                 1245             


Ile Phe  Gln Lys Ala Tyr Glu  His Glu Gln His Ile  Ser Glu Ser 
    1250                 1255                 1260             


Ile Asn  Asn Ile Val Asp His  Ala Ile Lys Ser Lys  Asp His Ala 
    1265                 1270                 1275             


Thr Phe  Asn Phe Leu Gln Trp  Tyr Val Ala Glu Gln  His Glu Glu 
    1280                 1285                 1290             


Glu Val  Leu Phe Lys Asp Ile  Leu Asp Lys Ile Glu  Leu Ile Gly 
    1295                 1300                 1305             


Asn Glu  Asn His Gly Leu Tyr  Leu Ala Asp Gln Tyr  Val Lys Gly 
    1310                 1315                 1320             


Ile Ala  Lys Ser Arg Lys Ser  Gly Ser 
    1325                 1330         


<210> 179
<211> 1310
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 179
Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser 
1               5                   10                  15      


Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val 
            20                  25                  30          


Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr 
        35                  40                  45              


Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe 
    50                  55                  60                  


Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr 
65                  70                  75                  80  


Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp 
                85                  90                  95      


Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val 
            100                 105                 110         


Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val 
        115                 120                 125             


Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val 
    130                 135                 140                 


Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe 
145                 150                 155                 160 


Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu 
                165                 170                 175     


Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His 
            180                 185                 190         


Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu 
        195                 200                 205             


Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln 
    210                 215                 220                 


Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser 
225                 230                 235                 240 


Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln 
                245                 250                 255     


Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp 
            260                 265                 270         


Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu 
        275                 280                 285             


Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg 
    290                 295                 300                 


Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu 
305                 310                 315                 320 


Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr 
                325                 330                 335     


Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val 
            340                 345                 350         


Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser 
        355                 360                 365             


Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser 
    370                 375                 380                 


Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr 
385                 390                 395                 400 


Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly 
                405                 410                 415     


Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly 
            420                 425                 430         


Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro 
        435                 440                 445             


Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro 
    450                 455                 460                 


Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr 
465                 470                 475                 480 


Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val 
                485                 490                 495     


Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro 
            500                 505                 510         


Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe 
        515                 520                 525             


Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe 
    530                 535                 540                 


Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala 
545                 550                 555                 560 


Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser 
                565                 570                 575     


Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln 
            580                 585                 590         


Val Ala Val Leu Tyr Gln Gly Val Asn Cys Thr Glu Val Pro Val Ala 
        595                 600                 605             


Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly 
    610                 615                 620                 


Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His 
625                 630                 635                 640 


Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys 
                645                 650                 655     


Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro Gly Ser Ala Ser Ser Val 
            660                 665                 670         


Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn 
        675                 680                 685             


Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr 
    690                 695                 700                 


Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser 
705                 710                 715                 720 


Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn 
                725                 730                 735     


Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu 
            740                 745                 750         


Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala 
        755                 760                 765             


Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly 
    770                 775                 780                 


Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg 
785                 790                 795                 800 


Ser Pro Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala 
                805                 810                 815     


Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg 
            820                 825                 830         


Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro 
        835                 840                 845             


Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala 
    850                 855                 860                 


Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Pro Ala Leu Gln 
865                 870                 875                 880 


Ile Pro Phe Pro Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val 
                885                 890                 895     


Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe 
            900                 905                 910         


Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Pro Ser 
        915                 920                 925             


Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu 
    930                 935                 940                 


Asn Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser 
945                 950                 955                 960 


Val Leu Asn Asp Ile Leu Ser Arg Leu Asp Pro Pro Glu Ala Glu Val 
                965                 970                 975     


Gln Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser Leu Gln Thr Tyr 
            980                 985                 990         


Val Thr Gln Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
        995                 1000                 1005             


Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1010                 1015                 1020             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1025                 1030                 1035             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1040                 1045                 1050             


Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1055                 1060                 1065             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1070                 1075                 1080             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1085                 1090                 1095             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1100                 1105                 1110             


Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro 
    1115                 1120                 1125             


Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Gly  Ser Gly Gly 
    1130                 1135                 1140             


Ser Gly  Asp Ile Ile Lys Leu  Leu Asn Glu Gln Val  Asn Lys Glu 
    1145                 1150                 1155             


Met Gln  Ser Ser Asn Leu Tyr  Met Ser Met Ser Ser  Trp Cys Tyr 
    1160                 1165                 1170             


Thr His  Ser Leu Asp Gly Ala  Gly Leu Phe Leu Phe  Asp His Ala 
    1175                 1180                 1185             


Ala Glu  Glu Tyr Glu His Ala  Lys Lys Leu Ile Ile  Phe Leu Asn 
    1190                 1195                 1200             


Glu Asn  Asn Val Pro Val Gln  Leu Thr Ser Ile Ser  Ala Pro Glu 
    1205                 1210                 1215             


His Lys  Phe Glu Gly Leu Thr  Gln Ile Phe Gln Lys  Ala Tyr Glu 
    1220                 1225                 1230             


His Glu  Gln His Ile Ser Glu  Ser Ile Asn Asn Ile  Val Asp His 
    1235                 1240                 1245             


Ala Ile  Lys Ser Lys Asp His  Ala Thr Phe Asn Phe  Leu Gln Trp 
    1250                 1255                 1260             


Tyr Val  Ala Glu Gln His Glu  Glu Glu Val Leu Phe  Lys Asp Ile 
    1265                 1270                 1275             


Leu Asp  Lys Ile Glu Leu Ile  Gly Asn Glu Asn His  Gly Leu Tyr 
    1280                 1285                 1290             


Leu Ala  Asp Gln Tyr Val Lys  Gly Ile Ala Lys Ser  Arg Lys Ser 
    1295                 1300                 1305             


Gly Ser  
    1310 


<210> 180
<211> 1310
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 180
Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser 
1               5                   10                  15      


Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val 
            20                  25                  30          


Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr 
        35                  40                  45              


Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe 
    50                  55                  60                  


Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr 
65                  70                  75                  80  


Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp 
                85                  90                  95      


Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val 
            100                 105                 110         


Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val 
        115                 120                 125             


Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val 
    130                 135                 140                 


Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe 
145                 150                 155                 160 


Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu 
                165                 170                 175     


Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His 
            180                 185                 190         


Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu 
        195                 200                 205             


Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln 
    210                 215                 220                 


Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser 
225                 230                 235                 240 


Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln 
                245                 250                 255     


Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp 
            260                 265                 270         


Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu 
        275                 280                 285             


Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg 
    290                 295                 300                 


Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu 
305                 310                 315                 320 


Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr 
                325                 330                 335     


Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val 
            340                 345                 350         


Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Cys 
        355                 360                 365             


Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser 
    370                 375                 380                 


Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr 
385                 390                 395                 400 


Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly 
                405                 410                 415     


Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly 
            420                 425                 430         


Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro 
        435                 440                 445             


Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro 
    450                 455                 460                 


Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr 
465                 470                 475                 480 


Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val 
                485                 490                 495     


Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro 
            500                 505                 510         


Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe 
        515                 520                 525             


Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe 
    530                 535                 540                 


Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala 
545                 550                 555                 560 


Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser 
                565                 570                 575     


Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln 
            580                 585                 590         


Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala 
        595                 600                 605             


Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly 
    610                 615                 620                 


Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His 
625                 630                 635                 640 


Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys 
                645                 650                 655     


Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro Gly Ser Ala Ser Ser Val 
            660                 665                 670         


Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn 
        675                 680                 685             


Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr 
    690                 695                 700                 


Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser 
705                 710                 715                 720 


Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn 
                725                 730                 735     


Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu 
            740                 745                 750         


Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala 
        755                 760                 765             


Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly 
    770                 775                 780                 


Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg 
785                 790                 795                 800 


Ser Pro Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala 
                805                 810                 815     


Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg 
            820                 825                 830         


Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro 
        835                 840                 845             


Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala 
    850                 855                 860                 


Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Pro Ala Leu Gln 
865                 870                 875                 880 


Ile Pro Phe Pro Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val 
                885                 890                 895     


Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe 
            900                 905                 910         


Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Pro Ser 
        915                 920                 925             


Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu 
    930                 935                 940                 


Asn Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser 
945                 950                 955                 960 


Val Leu Asn Asp Ile Leu Ser Arg Leu Cys Pro Pro Glu Ala Glu Val 
                965                 970                 975     


Gln Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser Leu Gln Thr Tyr 
            980                 985                 990         


Val Thr Gln Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
        995                 1000                 1005             


Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1010                 1015                 1020             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1025                 1030                 1035             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1040                 1045                 1050             


Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1055                 1060                 1065             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1070                 1075                 1080             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1085                 1090                 1095             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1100                 1105                 1110             


Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro 
    1115                 1120                 1125             


Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Gly  Ser Gly Gly 
    1130                 1135                 1140             


Ser Gly  Asp Ile Ile Lys Leu  Leu Asn Glu Gln Val  Asn Lys Glu 
    1145                 1150                 1155             


Met Gln  Ser Ser Asn Leu Tyr  Met Ser Met Ser Ser  Trp Cys Tyr 
    1160                 1165                 1170             


Thr His  Ser Leu Asp Gly Ala  Gly Leu Phe Leu Phe  Asp His Ala 
    1175                 1180                 1185             


Ala Glu  Glu Tyr Glu His Ala  Lys Lys Leu Ile Ile  Phe Leu Asn 
    1190                 1195                 1200             


Glu Asn  Asn Val Pro Val Gln  Leu Thr Ser Ile Ser  Ala Pro Glu 
    1205                 1210                 1215             


His Lys  Phe Glu Gly Leu Thr  Gln Ile Phe Gln Lys  Ala Tyr Glu 
    1220                 1225                 1230             


His Glu  Gln His Ile Ser Glu  Ser Ile Asn Asn Ile  Val Asp His 
    1235                 1240                 1245             


Ala Ile  Lys Ser Lys Asp His  Ala Thr Phe Asn Phe  Leu Gln Trp 
    1250                 1255                 1260             


Tyr Val  Ala Glu Gln His Glu  Glu Glu Val Leu Phe  Lys Asp Ile 
    1265                 1270                 1275             


Leu Asp  Lys Ile Glu Leu Ile  Gly Asn Glu Asn His  Gly Leu Tyr 
    1280                 1285                 1290             


Leu Ala  Asp Gln Tyr Val Lys  Gly Ile Ala Lys Ser  Arg Lys Ser 
    1295                 1300                 1305             


Gly Ser  
    1310 


<210> 181
<211> 1310
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 181
Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser 
1               5                   10                  15      


Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val 
            20                  25                  30          


Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr 
        35                  40                  45              


Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe 
    50                  55                  60                  


Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr 
65                  70                  75                  80  


Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp 
                85                  90                  95      


Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val 
            100                 105                 110         


Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val 
        115                 120                 125             


Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val 
    130                 135                 140                 


Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe 
145                 150                 155                 160 


Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu 
                165                 170                 175     


Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His 
            180                 185                 190         


Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu 
        195                 200                 205             


Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln 
    210                 215                 220                 


Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser 
225                 230                 235                 240 


Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln 
                245                 250                 255     


Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp 
            260                 265                 270         


Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu 
        275                 280                 285             


Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg 
    290                 295                 300                 


Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu 
305                 310                 315                 320 


Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr 
                325                 330                 335     


Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val 
            340                 345                 350         


Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Cys 
        355                 360                 365             


Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser 
    370                 375                 380                 


Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr 
385                 390                 395                 400 


Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly 
                405                 410                 415     


Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly 
            420                 425                 430         


Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro 
        435                 440                 445             


Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro 
    450                 455                 460                 


Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr 
465                 470                 475                 480 


Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val 
                485                 490                 495     


Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro 
            500                 505                 510         


Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe 
        515                 520                 525             


Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe 
    530                 535                 540                 


Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala 
545                 550                 555                 560 


Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser 
                565                 570                 575     


Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln 
            580                 585                 590         


Val Ala Val Leu Tyr Gln Gly Val Asn Cys Thr Glu Val Pro Val Ala 
        595                 600                 605             


Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly 
    610                 615                 620                 


Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His 
625                 630                 635                 640 


Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys 
                645                 650                 655     


Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro Gly Ser Ala Ser Ser Val 
            660                 665                 670         


Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn 
        675                 680                 685             


Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr 
    690                 695                 700                 


Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser 
705                 710                 715                 720 


Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn 
                725                 730                 735     


Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu 
            740                 745                 750         


Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala 
        755                 760                 765             


Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly 
    770                 775                 780                 


Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg 
785                 790                 795                 800 


Ser Pro Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala 
                805                 810                 815     


Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg 
            820                 825                 830         


Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro 
        835                 840                 845             


Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala 
    850                 855                 860                 


Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Pro Ala Leu Gln 
865                 870                 875                 880 


Ile Pro Phe Pro Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val 
                885                 890                 895     


Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe 
            900                 905                 910         


Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Pro Ser 
        915                 920                 925             


Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu 
    930                 935                 940                 


Asn Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser 
945                 950                 955                 960 


Val Leu Asn Asp Ile Leu Ser Arg Leu Cys Pro Pro Glu Ala Glu Val 
                965                 970                 975     


Gln Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser Leu Gln Thr Tyr 
            980                 985                 990         


Val Thr Gln Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
        995                 1000                 1005             


Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1010                 1015                 1020             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1025                 1030                 1035             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1040                 1045                 1050             


Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1055                 1060                 1065             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1070                 1075                 1080             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1085                 1090                 1095             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1100                 1105                 1110             


Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro 
    1115                 1120                 1125             


Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Gly  Ser Gly Gly 
    1130                 1135                 1140             


Ser Gly  Asp Ile Ile Lys Leu  Leu Asn Glu Gln Val  Asn Lys Glu 
    1145                 1150                 1155             


Met Gln  Ser Ser Asn Leu Tyr  Met Ser Met Ser Ser  Trp Cys Tyr 
    1160                 1165                 1170             


Thr His  Ser Leu Asp Gly Ala  Gly Leu Phe Leu Phe  Asp His Ala 
    1175                 1180                 1185             


Ala Glu  Glu Tyr Glu His Ala  Lys Lys Leu Ile Ile  Phe Leu Asn 
    1190                 1195                 1200             


Glu Asn  Asn Val Pro Val Gln  Leu Thr Ser Ile Ser  Ala Pro Glu 
    1205                 1210                 1215             


His Lys  Phe Glu Gly Leu Thr  Gln Ile Phe Gln Lys  Ala Tyr Glu 
    1220                 1225                 1230             


His Glu  Gln His Ile Ser Glu  Ser Ile Asn Asn Ile  Val Asp His 
    1235                 1240                 1245             


Ala Ile  Lys Ser Lys Asp His  Ala Thr Phe Asn Phe  Leu Gln Trp 
    1250                 1255                 1260             


Tyr Val  Ala Glu Gln His Glu  Glu Glu Val Leu Phe  Lys Asp Ile 
    1265                 1270                 1275             


Leu Asp  Lys Ile Glu Leu Ile  Gly Asn Glu Asn His  Gly Leu Tyr 
    1280                 1285                 1290             


Leu Ala  Asp Gln Tyr Val Lys  Gly Ile Ala Lys Ser  Arg Lys Ser 
    1295                 1300                 1305             


Gly Ser  
    1310 


<210> 182
<211> 1332
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 182
Ser Ser Gln Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala 
1               5                   10                  15      


Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe 
            20                  25                  30          


Arg Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe 
        35                  40                  45              


Ser Asn Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly 
    50                  55                  60                  


Thr Lys Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr 
65                  70                  75                  80  


Phe Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly 
                85                  90                  95      


Thr Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala 
            100                 105                 110         


Thr Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro 
        115                 120                 125             


Phe Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser 
    130                 135                 140                 


Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val 
145                 150                 155                 160 


Ser Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys 
                165                 170                 175     


Asn Leu Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile 
            180                 185                 190         


Tyr Ser Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly 
        195                 200                 205             


Phe Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile 
    210                 215                 220                 


Thr Arg Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro 
225                 230                 235                 240 


Gly Asp Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val 
                245                 250                 255     


Gly Tyr Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly 
            260                 265                 270         


Thr Ile Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr 
        275                 280                 285             


Lys Cys Thr Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr 
    290                 295                 300                 


Ser Asn Phe Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn 
305                 310                 315                 320 


Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe 
                325                 330                 335     


Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala 
            340                 345                 350         


Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys 
        355                 360                 365             


Tyr Gly Val Cys Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val 
    370                 375                 380                 


Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala 
385                 390                 395                 400 


Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp 
                405                 410                 415     


Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser 
            420                 425                 430         


Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser 
        435                 440                 445             


Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala 
    450                 455                 460                 


Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro 
465                 470                 475                 480 


Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro 
                485                 490                 495     


Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr 
            500                 505                 510         


Val Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val 
        515                 520                 525             


Asn Phe Asn Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser 
    530                 535                 540                 


Asn Lys Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp 
545                 550                 555                 560 


Thr Thr Asp Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile 
                565                 570                 575     


Thr Pro Cys Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn 
            580                 585                 590         


Thr Ser Asn Gln Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu 
        595                 600                 605             


Val Pro Val Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val 
    610                 615                 620                 


Tyr Ser Thr Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile 
625                 630                 635                 640 


Gly Ala Glu His Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly 
                645                 650                 655     


Ala Gly Ile Cys Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro Gly Ser 
            660                 665                 670         


Ala Ser Ser Val Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu 
        675                 680                 685             


Gly Ala Glu Asn Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro 
    690                 695                 700                 


Thr Asn Phe Thr Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met 
705                 710                 715                 720 


Thr Lys Thr Ser Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr 
                725                 730                 735     


Glu Cys Ser Asn Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu 
            740                 745                 750         


Asn Arg Ala Leu Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln 
        755                 760                 765             


Glu Val Phe Ala Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys 
    770                 775                 780                 


Asp Phe Gly Gly Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys 
785                 790                 795                 800 


Pro Ser Lys Arg Ser Pro Ile Glu Asp Leu Leu Phe Asn Lys Val Thr 
                805                 810                 815     


Leu Ala Asp Ala Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp 
            820                 825                 830         


Ile Ala Ala Arg Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr 
        835                 840                 845             


Val Leu Pro Pro Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser 
    850                 855                 860                 


Ala Leu Leu Ala Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly 
865                 870                 875                 880 


Pro Ala Leu Gln Ile Pro Phe Pro Met Gln Met Ala Tyr Arg Phe Asn 
                885                 890                 895     


Gly Ile Gly Val Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile 
            900                 905                 910         


Ala Asn Gln Phe Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser 
        915                 920                 925             


Ser Thr Pro Ser Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn 
    930                 935                 940                 


Ala Gln Ala Leu Asn Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly 
945                 950                 955                 960 


Ala Ile Ser Ser Val Leu Asn Asp Ile Leu Ser Arg Leu Cys Pro Pro 
                965                 970                 975     


Glu Ala Glu Val Gln Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser 
            980                 985                 990         


Leu Gln Thr Tyr Val Thr Gln Gln  Leu Ile Arg Ala Ala  Glu Ile Arg 
        995                 1000                 1005             


Ala Ser  Ala Asn Leu Ala Ala  Thr Lys Met Ser Glu  Cys Val Leu 
    1010                 1015                 1020             


Gly Gln  Ser Lys Arg Val Asp  Phe Cys Gly Lys Gly  Tyr His Leu 
    1025                 1030                 1035             


Met Ser  Phe Pro Gln Ser Ala  Pro His Gly Val Val  Phe Leu His 
    1040                 1045                 1050             


Val Thr  Tyr Val Pro Ala Gln  Glu Lys Asn Phe Thr  Thr Ala Pro 
    1055                 1060                 1065             


Ala Ile  Cys His Asp Gly Lys  Ala His Phe Pro Arg  Glu Gly Val 
    1070                 1075                 1080             


Phe Val  Ser Asn Gly Thr His  Trp Phe Val Thr Gln  Arg Asn Phe 
    1085                 1090                 1095             


Tyr Glu  Pro Gln Ile Ile Thr  Thr Asp Asn Thr Phe  Val Ser Gly 
    1100                 1105                 1110             


Asn Cys  Asp Val Val Ile Gly  Ile Val Asn Asn Thr  Val Tyr Asp 
    1115                 1120                 1125             


Pro Leu  Gln Ser Glu Leu Asp  Ser Ile Lys Glu Glu  Leu Asp Lys 
    1130                 1135                 1140             


Ile His  Lys Asn Leu Asp Ser  Ile Lys Glu Glu Leu  Asp Lys Ile 
    1145                 1150                 1155             


His Lys  Asn Gly Ser Gly Gly  Ser Gly Asp Ile Ile  Lys Leu Leu 
    1160                 1165                 1170             


Asn Glu  Gln Val Asn Lys Glu  Met Gln Ser Ser Asn  Leu Tyr Met 
    1175                 1180                 1185             


Ser Met  Ser Ser Trp Cys Tyr  Thr His Ser Leu Asp  Gly Ala Gly 
    1190                 1195                 1200             


Leu Phe  Leu Phe Asp His Ala  Ala Glu Glu Tyr Glu  His Ala Lys 
    1205                 1210                 1215             


Lys Leu  Ile Ile Phe Leu Asn  Glu Asn Asn Val Pro  Val Gln Leu 
    1220                 1225                 1230             


Thr Ser  Ile Ser Ala Pro Glu  His Lys Phe Glu Gly  Leu Thr Gln 
    1235                 1240                 1245             


Ile Phe  Gln Lys Ala Tyr Glu  His Glu Gln His Ile  Ser Glu Ser 
    1250                 1255                 1260             


Ile Asn  Asn Ile Val Asp His  Ala Ile Lys Ser Lys  Asp His Ala 
    1265                 1270                 1275             


Thr Phe  Asn Phe Leu Gln Trp  Tyr Val Ala Glu Gln  His Glu Glu 
    1280                 1285                 1290             


Glu Val  Leu Phe Lys Asp Ile  Leu Asp Lys Ile Glu  Leu Ile Gly 
    1295                 1300                 1305             


Asn Glu  Asn His Gly Leu Tyr  Leu Ala Asp Gln Tyr  Val Lys Gly 
    1310                 1315                 1320             


Ile Ala  Lys Ser Arg Lys Ser  Gly Ser 
    1325                 1330         


<210> 183
<211> 1332
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 183
Ser Ser Gln Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala 
1               5                   10                  15      


Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe 
            20                  25                  30          


Arg Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe 
        35                  40                  45              


Ser Asn Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly 
    50                  55                  60                  


Thr Lys Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr 
65                  70                  75                  80  


Phe Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly 
                85                  90                  95      


Thr Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala 
            100                 105                 110         


Thr Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro 
        115                 120                 125             


Phe Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser 
    130                 135                 140                 


Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val 
145                 150                 155                 160 


Ser Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys 
                165                 170                 175     


Asn Leu Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile 
            180                 185                 190         


Tyr Ser Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly 
        195                 200                 205             


Phe Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile 
    210                 215                 220                 


Thr Arg Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro 
225                 230                 235                 240 


Gly Asp Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val 
                245                 250                 255     


Gly Tyr Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly 
            260                 265                 270         


Thr Ile Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr 
        275                 280                 285             


Lys Cys Thr Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr 
    290                 295                 300                 


Ser Asn Phe Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn 
305                 310                 315                 320 


Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe 
                325                 330                 335     


Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala 
            340                 345                 350         


Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys 
        355                 360                 365             


Tyr Gly Val Cys Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val 
    370                 375                 380                 


Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala 
385                 390                 395                 400 


Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp 
                405                 410                 415     


Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser 
            420                 425                 430         


Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser 
        435                 440                 445             


Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala 
    450                 455                 460                 


Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro 
465                 470                 475                 480 


Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro 
                485                 490                 495     


Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr 
            500                 505                 510         


Val Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val 
        515                 520                 525             


Asn Phe Asn Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser 
    530                 535                 540                 


Asn Lys Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp 
545                 550                 555                 560 


Thr Thr Asp Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile 
                565                 570                 575     


Thr Pro Cys Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn 
            580                 585                 590         


Thr Ser Asn Gln Val Ala Val Leu Tyr Gln Gly Val Asn Cys Thr Glu 
        595                 600                 605             


Val Pro Val Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val 
    610                 615                 620                 


Tyr Ser Thr Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile 
625                 630                 635                 640 


Gly Ala Glu His Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly 
                645                 650                 655     


Ala Gly Ile Cys Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro Gly Ser 
            660                 665                 670         


Ala Ser Ser Val Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu 
        675                 680                 685             


Gly Ala Glu Asn Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro 
    690                 695                 700                 


Thr Asn Phe Thr Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met 
705                 710                 715                 720 


Thr Lys Thr Ser Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr 
                725                 730                 735     


Glu Cys Ser Asn Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu 
            740                 745                 750         


Asn Arg Ala Leu Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln 
        755                 760                 765             


Glu Val Phe Ala Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys 
    770                 775                 780                 


Asp Phe Gly Gly Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys 
785                 790                 795                 800 


Pro Ser Lys Arg Ser Pro Ile Glu Asp Leu Leu Phe Asn Lys Val Thr 
                805                 810                 815     


Leu Ala Asp Ala Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp 
            820                 825                 830         


Ile Ala Ala Arg Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr 
        835                 840                 845             


Val Leu Pro Pro Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser 
    850                 855                 860                 


Ala Leu Leu Ala Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly 
865                 870                 875                 880 


Pro Ala Leu Gln Ile Pro Phe Pro Met Gln Met Ala Tyr Arg Phe Asn 
                885                 890                 895     


Gly Ile Gly Val Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile 
            900                 905                 910         


Ala Asn Gln Phe Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser 
        915                 920                 925             


Ser Thr Pro Ser Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn 
    930                 935                 940                 


Ala Gln Ala Leu Asn Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly 
945                 950                 955                 960 


Ala Ile Ser Ser Val Leu Asn Asp Ile Leu Ser Arg Leu Cys Pro Pro 
                965                 970                 975     


Glu Ala Glu Val Gln Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser 
            980                 985                 990         


Leu Gln Thr Tyr Val Thr Gln Gln  Leu Ile Arg Ala Ala  Glu Ile Arg 
        995                 1000                 1005             


Ala Ser  Ala Asn Leu Ala Ala  Thr Lys Met Ser Glu  Cys Val Leu 
    1010                 1015                 1020             


Gly Gln  Ser Lys Arg Val Asp  Phe Cys Gly Lys Gly  Tyr His Leu 
    1025                 1030                 1035             


Met Ser  Phe Pro Gln Ser Ala  Pro His Gly Val Val  Phe Leu His 
    1040                 1045                 1050             


Val Thr  Tyr Val Pro Ala Gln  Glu Lys Asn Phe Thr  Thr Ala Pro 
    1055                 1060                 1065             


Ala Ile  Cys His Asp Gly Lys  Ala His Phe Pro Arg  Glu Gly Val 
    1070                 1075                 1080             


Phe Val  Ser Asn Gly Thr His  Trp Phe Val Thr Gln  Arg Asn Phe 
    1085                 1090                 1095             


Tyr Glu  Pro Gln Ile Ile Thr  Thr Asp Asn Thr Phe  Val Ser Gly 
    1100                 1105                 1110             


Asn Cys  Asp Val Val Ile Gly  Ile Val Asn Asn Thr  Val Tyr Asp 
    1115                 1120                 1125             


Pro Leu  Gln Ser Glu Leu Asp  Ser Ile Lys Glu Glu  Leu Asp Lys 
    1130                 1135                 1140             


Ile His  Lys Asn Leu Asp Ser  Ile Lys Glu Glu Leu  Asp Lys Ile 
    1145                 1150                 1155             


His Lys  Asn Gly Ser Gly Gly  Ser Gly Asp Ile Ile  Lys Leu Leu 
    1160                 1165                 1170             


Asn Glu  Gln Val Asn Lys Glu  Met Gln Ser Ser Asn  Leu Tyr Met 
    1175                 1180                 1185             


Ser Met  Ser Ser Trp Cys Tyr  Thr His Ser Leu Asp  Gly Ala Gly 
    1190                 1195                 1200             


Leu Phe  Leu Phe Asp His Ala  Ala Glu Glu Tyr Glu  His Ala Lys 
    1205                 1210                 1215             


Lys Leu  Ile Ile Phe Leu Asn  Glu Asn Asn Val Pro  Val Gln Leu 
    1220                 1225                 1230             


Thr Ser  Ile Ser Ala Pro Glu  His Lys Phe Glu Gly  Leu Thr Gln 
    1235                 1240                 1245             


Ile Phe  Gln Lys Ala Tyr Glu  His Glu Gln His Ile  Ser Glu Ser 
    1250                 1255                 1260             


Ile Asn  Asn Ile Val Asp His  Ala Ile Lys Ser Lys  Asp His Ala 
    1265                 1270                 1275             


Thr Phe  Asn Phe Leu Gln Trp  Tyr Val Ala Glu Gln  His Glu Glu 
    1280                 1285                 1290             


Glu Val  Leu Phe Lys Asp Ile  Leu Asp Lys Ile Glu  Leu Ile Gly 
    1295                 1300                 1305             


Asn Glu  Asn His Gly Leu Tyr  Leu Ala Asp Gln Tyr  Val Lys Gly 
    1310                 1315                 1320             


Ile Ala  Lys Ser Arg Lys Ser  Gly Ser 
    1325                 1330         


<210> 184
<211> 396
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 184
His His His His His His His His Gly Pro Leu Glu Val Leu Phe Gln 
1               5                   10                  15      


Gly Pro Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala 
            20                  25                  30          


Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn 
        35                  40                  45              


Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr 
    50                  55                  60                  


Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe 
65                  70                  75                  80  


Thr Asn Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg 
                85                  90                  95      


Gln Ile Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys 
            100                 105                 110         


Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn 
        115                 120                 125             


Leu Asp Ser Lys Val Gly Gly Asn Lys Asn Tyr Leu Arg Arg Arg Phe 
    130                 135                 140                 


Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile 
145                 150                 155                 160 


Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys 
                165                 170                 175     


Tyr Arg Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly 
            180                 185                 190         


Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala 
        195                 200                 205             


Pro Ala Thr Val Cys Gly Pro Gly Ser Gly Gly Gly Gly Glu Ser Gln 
    210                 215                 220                 


Val Arg Gln Gln Phe Ser Lys Asp Ile Glu Lys Leu Leu Asn Glu Gln 
225                 230                 235                 240 


Val Asn Lys Glu Met Gln Ser Ser Asn Leu Tyr Met Ser Met Ser Ser 
                245                 250                 255     


Trp Cys Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp 
            260                 265                 270         


His Ala Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe Leu 
        275                 280                 285             


Asn Glu Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro Glu 
    290                 295                 300                 


His Lys Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu His 
305                 310                 315                 320 


Glu Gln His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala Ile 
                325                 330                 335     


Lys Ser Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala 
            340                 345                 350         


Glu Gln His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys Ile 
        355                 360                 365             


Glu Leu Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr 
    370                 375                 380                 


Val Lys Gly Ile Ala Lys Ser Arg Lys Ser Gly Ser 
385                 390                 395     


<210> 185
<211> 396
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 185
His His His His His His His His Gly Pro Leu Glu Val Leu Phe Gln 
1               5                   10                  15      


Gly Pro Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala 
            20                  25                  30          


Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn 
        35                  40                  45              


Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr 
    50                  55                  60                  


Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe 
65                  70                  75                  80  


Thr Asn Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg 
                85                  90                  95      


Gln Ile Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys 
            100                 105                 110         


Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn 
        115                 120                 125             


Leu Asp Ser Lys Val Gly Gly Asn Lys Asn Tyr Leu Tyr Arg Arg Phe 
    130                 135                 140                 


Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile 
145                 150                 155                 160 


Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys 
                165                 170                 175     


Tyr Ala Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly 
            180                 185                 190         


Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala 
        195                 200                 205             


Pro Ala Thr Val Cys Gly Pro Gly Ser Gly Gly Gly Gly Glu Ser Gln 
    210                 215                 220                 


Val Arg Gln Gln Phe Ser Lys Asp Ile Glu Lys Leu Leu Asn Glu Gln 
225                 230                 235                 240 


Val Asn Lys Glu Met Gln Ser Ser Asn Leu Tyr Met Ser Met Ser Ser 
                245                 250                 255     


Trp Cys Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp 
            260                 265                 270         


His Ala Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe Leu 
        275                 280                 285             


Asn Glu Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro Glu 
    290                 295                 300                 


His Lys Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu His 
305                 310                 315                 320 


Glu Gln His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala Ile 
                325                 330                 335     


Lys Ser Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala 
            340                 345                 350         


Glu Gln His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys Ile 
        355                 360                 365             


Glu Leu Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr 
    370                 375                 380                 


Val Lys Gly Ile Ala Lys Ser Arg Lys Ser Gly Ser 
385                 390                 395     


<210> 186
<211> 1310
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 186
Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser 
1               5                   10                  15      


Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val 
            20                  25                  30          


Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr 
        35                  40                  45              


Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe 
    50                  55                  60                  


Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr 
65                  70                  75                  80  


Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp 
                85                  90                  95      


Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val 
            100                 105                 110         


Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val 
        115                 120                 125             


Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val 
    130                 135                 140                 


Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe 
145                 150                 155                 160 


Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu 
                165                 170                 175     


Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His 
            180                 185                 190         


Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu 
        195                 200                 205             


Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln 
    210                 215                 220                 


Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser 
225                 230                 235                 240 


Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln 
                245                 250                 255     


Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp 
            260                 265                 270         


Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu 
        275                 280                 285             


Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg 
    290                 295                 300                 


Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu 
305                 310                 315                 320 


Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr 
                325                 330                 335     


Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val 
            340                 345                 350         


Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser 
        355                 360                 365             


Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser 
    370                 375                 380                 


Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr 
385                 390                 395                 400 


Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly 
                405                 410                 415     


Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly 
            420                 425                 430         


Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro 
        435                 440                 445             


Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro 
    450                 455                 460                 


Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr 
465                 470                 475                 480 


Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val 
                485                 490                 495     


Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro 
            500                 505                 510         


Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe 
        515                 520                 525             


Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe 
    530                 535                 540                 


Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala 
545                 550                 555                 560 


Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser 
                565                 570                 575     


Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln 
            580                 585                 590         


Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala 
        595                 600                 605             


Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly 
    610                 615                 620                 


Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His 
625                 630                 635                 640 


Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys 
                645                 650                 655     


Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro Gly Ser Ala Ser Ser Val 
            660                 665                 670         


Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn 
        675                 680                 685             


Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr 
    690                 695                 700                 


Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser 
705                 710                 715                 720 


Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn 
                725                 730                 735     


Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu 
            740                 745                 750         


Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala 
        755                 760                 765             


Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly 
    770                 775                 780                 


Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg 
785                 790                 795                 800 


Ser Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala 
                805                 810                 815     


Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg 
            820                 825                 830         


Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro 
        835                 840                 845             


Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala 
    850                 855                 860                 


Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln 
865                 870                 875                 880 


Ile Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val 
                885                 890                 895     


Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe 
            900                 905                 910         


Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser 
        915                 920                 925             


Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu 
    930                 935                 940                 


Asn Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser 
945                 950                 955                 960 


Val Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val 
                965                 970                 975     


Gln Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser Leu Gln Thr Tyr 
            980                 985                 990         


Val Thr Gln Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
        995                 1000                 1005             


Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1010                 1015                 1020             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1025                 1030                 1035             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1040                 1045                 1050             


Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1055                 1060                 1065             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1070                 1075                 1080             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1085                 1090                 1095             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1100                 1105                 1110             


Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro 
    1115                 1120                 1125             


Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Gly  Ser Gly Gly 
    1130                 1135                 1140             


Ser Gly  Asp Ile Ile Lys Leu  Leu Asn Glu Gln Val  Asn Lys Glu 
    1145                 1150                 1155             


Met Gln  Ser Ser Asn Leu Tyr  Met Ser Met Ser Ser  Trp Cys Tyr 
    1160                 1165                 1170             


Thr His  Ser Leu Asp Gly Ala  Gly Leu Phe Leu Phe  Asp His Ala 
    1175                 1180                 1185             


Ala Glu  Glu Tyr Glu His Ala  Lys Lys Leu Ile Ile  Phe Leu Asn 
    1190                 1195                 1200             


Glu Asn  Asn Val Pro Val Gln  Leu Thr Ser Ile Ser  Ala Pro Glu 
    1205                 1210                 1215             


His Lys  Phe Glu Gly Leu Thr  Gln Ile Phe Gln Lys  Ala Tyr Glu 
    1220                 1225                 1230             


His Glu  Gln His Ile Ser Glu  Ser Ile Asn Asn Ile  Val Asp His 
    1235                 1240                 1245             


Ala Ile  Lys Ser Lys Asp His  Ala Thr Phe Asn Phe  Leu Gln Trp 
    1250                 1255                 1260             


Tyr Val  Ala Glu Gln His Glu  Glu Glu Val Leu Phe  Lys Asp Ile 
    1265                 1270                 1275             


Leu Asp  Lys Ile Glu Leu Ile  Gly Asn Glu Asn His  Gly Leu Tyr 
    1280                 1285                 1290             


Leu Ala  Asp Gln Tyr Val Lys  Gly Ile Ala Lys Ser  Arg Lys Ser 
    1295                 1300                 1305             


Gly Ser  
    1310 


<210> 187
<211> 1318
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 187
Ser Ser Gln Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala 
1               5                   10                  15      


Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe 
            20                  25                  30          


Arg Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe 
        35                  40                  45              


Ser Asn Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly 
    50                  55                  60                  


Thr Lys Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr 
65                  70                  75                  80  


Phe Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly 
                85                  90                  95      


Thr Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala 
            100                 105                 110         


Thr Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro 
        115                 120                 125             


Phe Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser 
    130                 135                 140                 


Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val 
145                 150                 155                 160 


Ser Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys 
                165                 170                 175     


Asn Leu Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile 
            180                 185                 190         


Tyr Ser Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly 
        195                 200                 205             


Phe Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile 
    210                 215                 220                 


Thr Arg Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro 
225                 230                 235                 240 


Gly Asp Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val 
                245                 250                 255     


Gly Tyr Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly 
            260                 265                 270         


Thr Ile Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr 
        275                 280                 285             


Lys Cys Thr Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr 
    290                 295                 300                 


Ser Asn Phe Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn 
305                 310                 315                 320 


Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe 
                325                 330                 335     


Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala 
            340                 345                 350         


Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys 
        355                 360                 365             


Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val 
    370                 375                 380                 


Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala 
385                 390                 395                 400 


Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp 
                405                 410                 415     


Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser 
            420                 425                 430         


Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser 
        435                 440                 445             


Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala 
    450                 455                 460                 


Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro 
465                 470                 475                 480 


Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro 
                485                 490                 495     


Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr 
            500                 505                 510         


Val Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val 
        515                 520                 525             


Asn Phe Asn Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser 
    530                 535                 540                 


Asn Lys Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp 
545                 550                 555                 560 


Thr Thr Asp Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile 
                565                 570                 575     


Thr Pro Cys Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn 
            580                 585                 590         


Thr Ser Asn Gln Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu 
        595                 600                 605             


Val Pro Val Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val 
    610                 615                 620                 


Tyr Ser Thr Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile 
625                 630                 635                 640 


Gly Ala Glu His Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly 
                645                 650                 655     


Ala Gly Ile Cys Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro Gly Ser 
            660                 665                 670         


Ala Ser Ser Val Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu 
        675                 680                 685             


Gly Ala Glu Asn Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro 
    690                 695                 700                 


Thr Asn Phe Thr Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met 
705                 710                 715                 720 


Thr Lys Thr Ser Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr 
                725                 730                 735     


Glu Cys Ser Asn Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu 
            740                 745                 750         


Asn Arg Ala Leu Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln 
        755                 760                 765             


Glu Val Phe Ala Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys 
    770                 775                 780                 


Asp Phe Gly Gly Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys 
785                 790                 795                 800 


Pro Ser Lys Arg Ser Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr 
                805                 810                 815     


Leu Ala Asp Ala Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp 
            820                 825                 830         


Ile Ala Ala Arg Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr 
        835                 840                 845             


Val Leu Pro Pro Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser 
    850                 855                 860                 


Ala Leu Leu Ala Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly 
865                 870                 875                 880 


Ala Ala Leu Gln Ile Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn 
                885                 890                 895     


Gly Ile Gly Val Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile 
            900                 905                 910         


Ala Asn Gln Phe Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser 
        915                 920                 925             


Ser Thr Ala Ser Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn 
    930                 935                 940                 


Ala Gln Ala Leu Asn Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly 
945                 950                 955                 960 


Ala Ile Ser Ser Val Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val 
                965                 970                 975     


Glu Ala Glu Val Gln Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser 
            980                 985                 990         


Leu Gln Thr Tyr Val Thr Gln Gln  Leu Ile Arg Ala Ala  Glu Ile Arg 
        995                 1000                 1005             


Ala Ser  Ala Asn Leu Ala Ala  Thr Lys Met Ser Glu  Cys Val Leu 
    1010                 1015                 1020             


Gly Gln  Ser Lys Arg Val Asp  Phe Cys Gly Lys Gly  Tyr His Leu 
    1025                 1030                 1035             


Met Ser  Phe Pro Gln Ser Ala  Pro His Gly Val Val  Phe Leu His 
    1040                 1045                 1050             


Val Thr  Tyr Val Pro Ala Gln  Glu Lys Asn Phe Thr  Thr Ala Pro 
    1055                 1060                 1065             


Ala Ile  Cys His Asp Gly Lys  Ala His Phe Pro Arg  Glu Gly Val 
    1070                 1075                 1080             


Phe Val  Ser Asn Gly Thr His  Trp Phe Val Thr Gln  Arg Asn Phe 
    1085                 1090                 1095             


Tyr Glu  Pro Gln Ile Ile Thr  Thr Asp Asn Thr Phe  Val Ser Gly 
    1100                 1105                 1110             


Asn Cys  Asp Val Val Ile Gly  Ile Val Asn Asn Thr  Val Tyr Asp 
    1115                 1120                 1125             


Pro Leu  Gln Ser Glu Leu Asp  Ser Ile Lys Glu Glu  Leu Asp Lys 
    1130                 1135                 1140             


Ile His  Lys Asn Gly Ser Gly  Gly Ser Gly Asp Ile  Ile Lys Leu 
    1145                 1150                 1155             


Leu Asn  Glu Gln Val Asn Lys  Glu Met Gln Ser Ser  Asn Leu Tyr 
    1160                 1165                 1170             


Met Ser  Met Ser Ser Trp Cys  Tyr Thr His Ser Leu  Asp Gly Ala 
    1175                 1180                 1185             


Gly Leu  Phe Leu Phe Asp His  Ala Ala Glu Glu Tyr  Glu His Ala 
    1190                 1195                 1200             


Lys Lys  Leu Ile Ile Phe Leu  Asn Glu Asn Asn Val  Pro Val Gln 
    1205                 1210                 1215             


Leu Thr  Ser Ile Ser Ala Pro  Glu His Lys Phe Glu  Gly Leu Thr 
    1220                 1225                 1230             


Gln Ile  Phe Gln Lys Ala Tyr  Glu His Glu Gln His  Ile Ser Glu 
    1235                 1240                 1245             


Ser Ile  Asn Asn Ile Val Asp  His Ala Ile Lys Ser  Lys Asp His 
    1250                 1255                 1260             


Ala Thr  Phe Asn Phe Leu Gln  Trp Tyr Val Ala Glu  Gln His Glu 
    1265                 1270                 1275             


Glu Glu  Val Leu Phe Lys Asp  Ile Leu Asp Lys Ile  Glu Leu Ile 
    1280                 1285                 1290             


Gly Asn  Glu Asn His Gly Leu  Tyr Leu Ala Asp Gln  Tyr Val Lys 
    1295                 1300                 1305             


Gly Ile  Ala Lys Ser Arg Lys  Ser Gly Ser 
    1310                 1315             


<210> 188
<211> 1332
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 188
Ser Ser Gln Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala 
1               5                   10                  15      


Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe 
            20                  25                  30          


Arg Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe 
        35                  40                  45              


Ser Asn Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly 
    50                  55                  60                  


Thr Lys Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr 
65                  70                  75                  80  


Phe Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly 
                85                  90                  95      


Thr Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala 
            100                 105                 110         


Thr Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro 
        115                 120                 125             


Phe Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser 
    130                 135                 140                 


Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val 
145                 150                 155                 160 


Ser Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys 
                165                 170                 175     


Asn Leu Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile 
            180                 185                 190         


Tyr Ser Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly 
        195                 200                 205             


Phe Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile 
    210                 215                 220                 


Thr Arg Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro 
225                 230                 235                 240 


Gly Asp Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val 
                245                 250                 255     


Gly Tyr Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly 
            260                 265                 270         


Thr Ile Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr 
        275                 280                 285             


Lys Cys Thr Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr 
    290                 295                 300                 


Ser Asn Phe Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn 
305                 310                 315                 320 


Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe 
                325                 330                 335     


Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala 
            340                 345                 350         


Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys 
        355                 360                 365             


Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val 
    370                 375                 380                 


Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala 
385                 390                 395                 400 


Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp 
                405                 410                 415     


Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser 
            420                 425                 430         


Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser 
        435                 440                 445             


Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala 
    450                 455                 460                 


Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro 
465                 470                 475                 480 


Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro 
                485                 490                 495     


Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr 
            500                 505                 510         


Val Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val 
        515                 520                 525             


Asn Phe Asn Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser 
    530                 535                 540                 


Asn Lys Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp 
545                 550                 555                 560 


Thr Thr Asp Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile 
                565                 570                 575     


Thr Pro Cys Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn 
            580                 585                 590         


Thr Ser Asn Gln Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu 
        595                 600                 605             


Val Pro Val Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val 
    610                 615                 620                 


Tyr Ser Thr Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile 
625                 630                 635                 640 


Gly Ala Glu His Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly 
                645                 650                 655     


Ala Gly Ile Cys Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro Gly Ser 
            660                 665                 670         


Ala Ser Ser Val Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu 
        675                 680                 685             


Gly Ala Glu Asn Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro 
    690                 695                 700                 


Thr Asn Phe Thr Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met 
705                 710                 715                 720 


Thr Lys Thr Ser Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr 
                725                 730                 735     


Glu Cys Ser Asn Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu 
            740                 745                 750         


Asn Arg Ala Leu Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln 
        755                 760                 765             


Glu Val Phe Ala Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys 
    770                 775                 780                 


Asp Phe Gly Gly Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys 
785                 790                 795                 800 


Pro Ser Lys Arg Ser Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr 
                805                 810                 815     


Leu Ala Asp Ala Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp 
            820                 825                 830         


Ile Ala Ala Arg Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr 
        835                 840                 845             


Val Leu Pro Pro Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser 
    850                 855                 860                 


Ala Leu Leu Ala Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly 
865                 870                 875                 880 


Ala Ala Leu Gln Ile Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn 
                885                 890                 895     


Gly Ile Gly Val Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile 
            900                 905                 910         


Ala Asn Gln Phe Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser 
        915                 920                 925             


Ser Thr Ala Ser Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn 
    930                 935                 940                 


Ala Gln Ala Leu Asn Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly 
945                 950                 955                 960 


Ala Ile Ser Ser Val Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val 
                965                 970                 975     


Glu Ala Glu Val Gln Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser 
            980                 985                 990         


Leu Gln Thr Tyr Val Thr Gln Gln  Leu Ile Arg Ala Ala  Glu Ile Arg 
        995                 1000                 1005             


Ala Ser  Ala Asn Leu Ala Ala  Thr Lys Met Ser Glu  Cys Val Leu 
    1010                 1015                 1020             


Gly Gln  Ser Lys Arg Val Asp  Phe Cys Gly Lys Gly  Tyr His Leu 
    1025                 1030                 1035             


Met Ser  Phe Pro Gln Ser Ala  Pro His Gly Val Val  Phe Leu His 
    1040                 1045                 1050             


Val Thr  Tyr Val Pro Ala Gln  Glu Lys Asn Phe Thr  Thr Ala Pro 
    1055                 1060                 1065             


Ala Ile  Cys His Asp Gly Lys  Ala His Phe Pro Arg  Glu Gly Val 
    1070                 1075                 1080             


Phe Val  Ser Asn Gly Thr His  Trp Phe Val Thr Gln  Arg Asn Phe 
    1085                 1090                 1095             


Tyr Glu  Pro Gln Ile Ile Thr  Thr Asp Asn Thr Phe  Val Ser Gly 
    1100                 1105                 1110             


Asn Cys  Asp Val Val Ile Gly  Ile Val Asn Asn Thr  Val Tyr Asp 
    1115                 1120                 1125             


Pro Leu  Gln Ser Glu Leu Asp  Ser Ile Lys Glu Glu  Leu Asp Lys 
    1130                 1135                 1140             


Ile His  Lys Asn Leu Asp Ser  Ile Lys Glu Glu Leu  Asp Lys Ile 
    1145                 1150                 1155             


His Lys  Asn Gly Ser Gly Gly  Ser Gly Asp Ile Ile  Lys Leu Leu 
    1160                 1165                 1170             


Asn Glu  Gln Val Asn Lys Glu  Met Gln Ser Ser Asn  Leu Tyr Met 
    1175                 1180                 1185             


Ser Met  Ser Ser Trp Cys Tyr  Thr His Ser Leu Asp  Gly Ala Gly 
    1190                 1195                 1200             


Leu Phe  Leu Phe Asp His Ala  Ala Glu Glu Tyr Glu  His Ala Lys 
    1205                 1210                 1215             


Lys Leu  Ile Ile Phe Leu Asn  Glu Asn Asn Val Pro  Val Gln Leu 
    1220                 1225                 1230             


Thr Ser  Ile Ser Ala Pro Glu  His Lys Phe Glu Gly  Leu Thr Gln 
    1235                 1240                 1245             


Ile Phe  Gln Lys Ala Tyr Glu  His Glu Gln His Ile  Ser Glu Ser 
    1250                 1255                 1260             


Ile Asn  Asn Ile Val Asp His  Ala Ile Lys Ser Lys  Asp His Ala 
    1265                 1270                 1275             


Thr Phe  Asn Phe Leu Gln Trp  Tyr Val Ala Glu Gln  His Glu Glu 
    1280                 1285                 1290             


Glu Val  Leu Phe Lys Asp Ile  Leu Asp Lys Ile Glu  Leu Ile Gly 
    1295                 1300                 1305             


Asn Glu  Asn His Gly Leu Tyr  Leu Ala Asp Gln Tyr  Val Lys Gly 
    1310                 1315                 1320             


Ile Ala  Lys Ser Arg Lys Ser  Gly Ser 
    1325                 1330         


<210> 189
<211> 676
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 189
Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg 
1               5                   10                  15      


Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val 
            20                  25                  30          


Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys 
        35                  40                  45              


Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn 
    50                  55                  60                  


Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile 
65                  70                  75                  80  


Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro 
                85                  90                  95      


Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp 
            100                 105                 110         


Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys 
        115                 120                 125             


Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln 
    130                 135                 140                 


Ala Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe 
145                 150                 155                 160 


Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln 
                165                 170                 175     


Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala 
            180                 185                 190         


Thr Val Cys Gly Pro Gly Ser Gly Gly Ser Gly Ser Ser Gln Cys Val 
        195                 200                 205             


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
    210                 215                 220                 


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
225                 230                 235                 240 


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
                245                 250                 255     


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
            260                 265                 270         


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
        275                 280                 285             


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
    290                 295                 300                 


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
305                 310                 315                 320 


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
                325                 330                 335     


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
            340                 345                 350         


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
        355                 360                 365             


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
    370                 375                 380                 


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
385                 390                 395                 400 


Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
                405                 410                 415     


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
            420                 425                 430         


Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
        435                 440                 445             


Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
    450                 455                 460                 


Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
465                 470                 475                 480 


Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Gly 
                485                 490                 495     


Ser Gly Gly Gly Gly Glu Ser Gln Val Arg Gln Gln Phe Ser Lys Asp 
            500                 505                 510         


Ile Glu Lys Leu Leu Asn Glu Gln Val Asn Lys Glu Met Gln Ser Ser 
        515                 520                 525             


Asn Leu Tyr Met Ser Met Ser Ser Trp Cys Tyr Thr His Ser Leu Asp 
    530                 535                 540                 


Gly Ala Gly Leu Phe Leu Phe Asp His Ala Ala Glu Glu Tyr Glu His 
545                 550                 555                 560 


Ala Lys Lys Leu Ile Ile Phe Leu Asn Glu Asn Asn Val Pro Val Gln 
                565                 570                 575     


Leu Thr Ser Ile Ser Ala Pro Glu His Lys Phe Glu Gly Leu Thr Gln 
            580                 585                 590         


Ile Phe Gln Lys Ala Tyr Glu His Glu Gln His Ile Ser Glu Ser Ile 
        595                 600                 605             


Asn Asn Ile Val Asp His Ala Ile Lys Ser Lys Asp His Ala Thr Phe 
    610                 615                 620                 


Asn Phe Leu Gln Trp Tyr Val Ala Glu Gln His Glu Glu Glu Val Leu 
625                 630                 635                 640 


Phe Lys Asp Ile Leu Asp Lys Ile Glu Leu Ile Gly Asn Glu Asn His 
                645                 650                 655     


Gly Leu Tyr Leu Ala Asp Gln Tyr Val Lys Gly Ile Ala Lys Ser Arg 
            660                 665                 670         


Lys Ser Gly Ser 
        675     


<210> 190
<211> 676
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 190
Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg 
1               5                   10                  15      


Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val 
            20                  25                  30          


Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys 
        35                  40                  45              


Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn 
    50                  55                  60                  


Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile 
65                  70                  75                  80  


Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro 
                85                  90                  95      


Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp 
            100                 105                 110         


Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys 
        115                 120                 125             


Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln 
    130                 135                 140                 


Ala Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Arg 
145                 150                 155                 160 


Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln 
                165                 170                 175     


Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala 
            180                 185                 190         


Thr Val Cys Gly Pro Gly Ser Gly Gly Ser Gly Ser Ser Gln Cys Val 
        195                 200                 205             


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
    210                 215                 220                 


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
225                 230                 235                 240 


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
                245                 250                 255     


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
            260                 265                 270         


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
        275                 280                 285             


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
    290                 295                 300                 


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
305                 310                 315                 320 


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
                325                 330                 335     


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
            340                 345                 350         


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
        355                 360                 365             


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
    370                 375                 380                 


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
385                 390                 395                 400 


Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
                405                 410                 415     


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
            420                 425                 430         


Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
        435                 440                 445             


Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
    450                 455                 460                 


Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
465                 470                 475                 480 


Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Gly 
                485                 490                 495     


Ser Gly Gly Gly Gly Glu Ser Gln Val Arg Gln Gln Phe Ser Lys Asp 
            500                 505                 510         


Ile Glu Lys Leu Leu Asn Glu Gln Val Asn Lys Glu Met Gln Ser Ser 
        515                 520                 525             


Asn Leu Tyr Met Ser Met Ser Ser Trp Cys Tyr Thr His Ser Leu Asp 
    530                 535                 540                 


Gly Ala Gly Leu Phe Leu Phe Asp His Ala Ala Glu Glu Tyr Glu His 
545                 550                 555                 560 


Ala Lys Lys Leu Ile Ile Phe Leu Asn Glu Asn Asn Val Pro Val Gln 
                565                 570                 575     


Leu Thr Ser Ile Ser Ala Pro Glu His Lys Phe Glu Gly Leu Thr Gln 
            580                 585                 590         


Ile Phe Gln Lys Ala Tyr Glu His Glu Gln His Ile Ser Glu Ser Ile 
        595                 600                 605             


Asn Asn Ile Val Asp His Ala Ile Lys Ser Lys Asp His Ala Thr Phe 
    610                 615                 620                 


Asn Phe Leu Gln Trp Tyr Val Ala Glu Gln His Glu Glu Glu Val Leu 
625                 630                 635                 640 


Phe Lys Asp Ile Leu Asp Lys Ile Glu Leu Ile Gly Asn Glu Asn His 
                645                 650                 655     


Gly Leu Tyr Leu Ala Asp Gln Tyr Val Lys Gly Ile Ala Lys Ser Arg 
            660                 665                 670         


Lys Ser Gly Ser 
        675     


<210> 191
<211> 676
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 191
Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg 
1               5                   10                  15      


Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val 
            20                  25                  30          


Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys 
        35                  40                  45              


Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn 
    50                  55                  60                  


Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile 
65                  70                  75                  80  


Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro 
                85                  90                  95      


Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp 
            100                 105                 110         


Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys 
        115                 120                 125             


Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln 
    130                 135                 140                 


Ala Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Ala 
145                 150                 155                 160 


Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln 
                165                 170                 175     


Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala 
            180                 185                 190         


Thr Val Cys Gly Pro Gly Ser Gly Gly Ser Gly Ser Ser Gln Cys Val 
        195                 200                 205             


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
    210                 215                 220                 


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
225                 230                 235                 240 


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
                245                 250                 255     


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
            260                 265                 270         


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
        275                 280                 285             


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
    290                 295                 300                 


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
305                 310                 315                 320 


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
                325                 330                 335     


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
            340                 345                 350         


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
        355                 360                 365             


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
    370                 375                 380                 


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
385                 390                 395                 400 


Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
                405                 410                 415     


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
            420                 425                 430         


Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
        435                 440                 445             


Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
    450                 455                 460                 


Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
465                 470                 475                 480 


Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Gly 
                485                 490                 495     


Ser Gly Gly Gly Gly Glu Ser Gln Val Arg Gln Gln Phe Ser Lys Asp 
            500                 505                 510         


Ile Glu Lys Leu Leu Asn Glu Gln Val Asn Lys Glu Met Gln Ser Ser 
        515                 520                 525             


Asn Leu Tyr Met Ser Met Ser Ser Trp Cys Tyr Thr His Ser Leu Asp 
    530                 535                 540                 


Gly Ala Gly Leu Phe Leu Phe Asp His Ala Ala Glu Glu Tyr Glu His 
545                 550                 555                 560 


Ala Lys Lys Leu Ile Ile Phe Leu Asn Glu Asn Asn Val Pro Val Gln 
                565                 570                 575     


Leu Thr Ser Ile Ser Ala Pro Glu His Lys Phe Glu Gly Leu Thr Gln 
            580                 585                 590         


Ile Phe Gln Lys Ala Tyr Glu His Glu Gln His Ile Ser Glu Ser Ile 
        595                 600                 605             


Asn Asn Ile Val Asp His Ala Ile Lys Ser Lys Asp His Ala Thr Phe 
    610                 615                 620                 


Asn Phe Leu Gln Trp Tyr Val Ala Glu Gln His Glu Glu Glu Val Leu 
625                 630                 635                 640 


Phe Lys Asp Ile Leu Asp Lys Ile Glu Leu Ile Gly Asn Glu Asn His 
                645                 650                 655     


Gly Leu Tyr Leu Ala Asp Gln Tyr Val Lys Gly Ile Ala Lys Ser Arg 
            660                 665                 670         


Lys Ser Gly Ser 
        675     


<210> 192
<211> 676
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 192
Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg 
1               5                   10                  15      


Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val 
            20                  25                  30          


Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys 
        35                  40                  45              


Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn 
    50                  55                  60                  


Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile 
65                  70                  75                  80  


Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro 
                85                  90                  95      


Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp 
            100                 105                 110         


Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys 
        115                 120                 125             


Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln 
    130                 135                 140                 


Ala Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe 
145                 150                 155                 160 


Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln 
                165                 170                 175     


Pro Tyr Arg Val Val Val Leu Ser Phe Glu Asn Lys Ser Ala Pro Ala 
            180                 185                 190         


Thr Val Cys Gly Pro Gly Ser Gly Gly Ser Gly Ser Ser Gln Cys Val 
        195                 200                 205             


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
    210                 215                 220                 


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
225                 230                 235                 240 


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
                245                 250                 255     


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
            260                 265                 270         


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
        275                 280                 285             


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
    290                 295                 300                 


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
305                 310                 315                 320 


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
                325                 330                 335     


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
            340                 345                 350         


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
        355                 360                 365             


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
    370                 375                 380                 


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
385                 390                 395                 400 


Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
                405                 410                 415     


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
            420                 425                 430         


Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
        435                 440                 445             


Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
    450                 455                 460                 


Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
465                 470                 475                 480 


Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Gly 
                485                 490                 495     


Ser Gly Gly Gly Gly Glu Ser Gln Val Arg Gln Gln Phe Ser Lys Asp 
            500                 505                 510         


Ile Glu Lys Leu Leu Asn Glu Gln Val Asn Lys Glu Met Gln Ser Ser 
        515                 520                 525             


Asn Leu Tyr Met Ser Met Ser Ser Trp Cys Tyr Thr His Ser Leu Asp 
    530                 535                 540                 


Gly Ala Gly Leu Phe Leu Phe Asp His Ala Ala Glu Glu Tyr Glu His 
545                 550                 555                 560 


Ala Lys Lys Leu Ile Ile Phe Leu Asn Glu Asn Asn Val Pro Val Gln 
                565                 570                 575     


Leu Thr Ser Ile Ser Ala Pro Glu His Lys Phe Glu Gly Leu Thr Gln 
            580                 585                 590         


Ile Phe Gln Lys Ala Tyr Glu His Glu Gln His Ile Ser Glu Ser Ile 
        595                 600                 605             


Asn Asn Ile Val Asp His Ala Ile Lys Ser Lys Asp His Ala Thr Phe 
    610                 615                 620                 


Asn Phe Leu Gln Trp Tyr Val Ala Glu Gln His Glu Glu Glu Val Leu 
625                 630                 635                 640 


Phe Lys Asp Ile Leu Asp Lys Ile Glu Leu Ile Gly Asn Glu Asn His 
                645                 650                 655     


Gly Leu Tyr Leu Ala Asp Gln Tyr Val Lys Gly Ile Ala Lys Ser Arg 
            660                 665                 670         


Lys Ser Gly Ser 
        675     


<210> 193
<211> 676
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 193
Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg 
1               5                   10                  15      


Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val 
            20                  25                  30          


Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys 
        35                  40                  45              


Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn 
    50                  55                  60                  


Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile 
65                  70                  75                  80  


Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro 
                85                  90                  95      


Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp 
            100                 105                 110         


Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys 
        115                 120                 125             


Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln 
    130                 135                 140                 


Ala Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe 
145                 150                 155                 160 


Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln 
                165                 170                 175     


Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Arg His Ala Pro Ala 
            180                 185                 190         


Thr Val Cys Gly Pro Gly Ser Gly Gly Ser Gly Ser Ser Gln Cys Val 
        195                 200                 205             


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
    210                 215                 220                 


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
225                 230                 235                 240 


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
                245                 250                 255     


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
            260                 265                 270         


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
        275                 280                 285             


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
    290                 295                 300                 


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
305                 310                 315                 320 


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
                325                 330                 335     


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
            340                 345                 350         


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
        355                 360                 365             


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
    370                 375                 380                 


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
385                 390                 395                 400 


Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
                405                 410                 415     


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
            420                 425                 430         


Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
        435                 440                 445             


Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
    450                 455                 460                 


Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
465                 470                 475                 480 


Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Gly 
                485                 490                 495     


Ser Gly Gly Gly Gly Glu Ser Gln Val Arg Gln Gln Phe Ser Lys Asp 
            500                 505                 510         


Ile Glu Lys Leu Leu Asn Glu Gln Val Asn Lys Glu Met Gln Ser Ser 
        515                 520                 525             


Asn Leu Tyr Met Ser Met Ser Ser Trp Cys Tyr Thr His Ser Leu Asp 
    530                 535                 540                 


Gly Ala Gly Leu Phe Leu Phe Asp His Ala Ala Glu Glu Tyr Glu His 
545                 550                 555                 560 


Ala Lys Lys Leu Ile Ile Phe Leu Asn Glu Asn Asn Val Pro Val Gln 
                565                 570                 575     


Leu Thr Ser Ile Ser Ala Pro Glu His Lys Phe Glu Gly Leu Thr Gln 
            580                 585                 590         


Ile Phe Gln Lys Ala Tyr Glu His Glu Gln His Ile Ser Glu Ser Ile 
        595                 600                 605             


Asn Asn Ile Val Asp His Ala Ile Lys Ser Lys Asp His Ala Thr Phe 
    610                 615                 620                 


Asn Phe Leu Gln Trp Tyr Val Ala Glu Gln His Glu Glu Glu Val Leu 
625                 630                 635                 640 


Phe Lys Asp Ile Leu Asp Lys Ile Glu Leu Ile Gly Asn Glu Asn His 
                645                 650                 655     


Gly Leu Tyr Leu Ala Asp Gln Tyr Val Lys Gly Ile Ala Lys Ser Arg 
            660                 665                 670         


Lys Ser Gly Ser 
        675     


<210> 194
<211> 378
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 194
Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg 
1               5                   10                  15      


Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val 
            20                  25                  30          


Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys 
        35                  40                  45              


Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn 
    50                  55                  60                  


Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile 
65                  70                  75                  80  


Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro 
                85                  90                  95      


Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp 
            100                 105                 110         


Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys 
        115                 120                 125             


Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln 
    130                 135                 140                 


Ala Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Ala 
145                 150                 155                 160 


Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln 
                165                 170                 175     


Pro Tyr Arg Val Val Val Leu Ser Phe Glu Asn Lys Ser Ala Pro Ala 
            180                 185                 190         


Thr Val Cys Gly Pro Gly Ser Gly Gly Gly Gly Glu Ser Gln Val Arg 
        195                 200                 205             


Gln Gln Phe Ser Lys Asp Ile Glu Lys Leu Leu Asn Glu Gln Val Asn 
    210                 215                 220                 


Lys Glu Met Gln Ser Ser Asn Leu Tyr Met Ser Met Ser Ser Trp Cys 
225                 230                 235                 240 


Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp His Ala 
                245                 250                 255     


Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe Leu Asn Glu 
            260                 265                 270         


Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro Glu His Lys 
        275                 280                 285             


Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu His Glu Gln 
    290                 295                 300                 


His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala Ile Lys Ser 
305                 310                 315                 320 


Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala Glu Gln 
                325                 330                 335     


His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys Ile Glu Leu 
            340                 345                 350         


Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr Val Lys 
        355                 360                 365             


Gly Ile Ala Lys Ser Arg Lys Ser Gly Ser 
    370                 375             


<210> 195
<211> 378
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 195
Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg 
1               5                   10                  15      


Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val 
            20                  25                  30          


Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys 
        35                  40                  45              


Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn 
    50                  55                  60                  


Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile 
65                  70                  75                  80  


Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro 
                85                  90                  95      


Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp 
            100                 105                 110         


Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys 
        115                 120                 125             


Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln 
    130                 135                 140                 


Ala Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Ala 
145                 150                 155                 160 


Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln 
                165                 170                 175     


Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Arg His Ala Pro Ala 
            180                 185                 190         


Thr Val Cys Gly Pro Gly Ser Gly Gly Gly Gly Glu Ser Gln Val Arg 
        195                 200                 205             


Gln Gln Phe Ser Lys Asp Ile Glu Lys Leu Leu Asn Glu Gln Val Asn 
    210                 215                 220                 


Lys Glu Met Gln Ser Ser Asn Leu Tyr Met Ser Met Ser Ser Trp Cys 
225                 230                 235                 240 


Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp His Ala 
                245                 250                 255     


Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe Leu Asn Glu 
            260                 265                 270         


Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro Glu His Lys 
        275                 280                 285             


Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu His Glu Gln 
    290                 295                 300                 


His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala Ile Lys Ser 
305                 310                 315                 320 


Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala Glu Gln 
                325                 330                 335     


His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys Ile Glu Leu 
            340                 345                 350         


Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr Val Lys 
        355                 360                 365             


Gly Ile Ala Lys Ser Arg Lys Ser Gly Ser 
    370                 375             


<210> 196
<211> 378
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 196
Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg 
1               5                   10                  15      


Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val 
            20                  25                  30          


Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys 
        35                  40                  45              


Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn 
    50                  55                  60                  


Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile 
65                  70                  75                  80  


Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro 
                85                  90                  95      


Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp 
            100                 105                 110         


Ser Lys Val Gly Gly Asn Lys Asn Tyr Leu Tyr Arg Arg Phe Arg Lys 
        115                 120                 125             


Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln 
    130                 135                 140                 


Ala Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Arg 
145                 150                 155                 160 


Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln 
                165                 170                 175     


Pro Tyr Arg Val Val Val Leu Ser Phe Glu Asn Lys Ser Ala Pro Ala 
            180                 185                 190         


Thr Val Cys Gly Pro Gly Ser Gly Gly Gly Gly Glu Ser Gln Val Arg 
        195                 200                 205             


Gln Gln Phe Ser Lys Asp Ile Glu Lys Leu Leu Asn Glu Gln Val Asn 
    210                 215                 220                 


Lys Glu Met Gln Ser Ser Asn Leu Tyr Met Ser Met Ser Ser Trp Cys 
225                 230                 235                 240 


Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp His Ala 
                245                 250                 255     


Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe Leu Asn Glu 
            260                 265                 270         


Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro Glu His Lys 
        275                 280                 285             


Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu His Glu Gln 
    290                 295                 300                 


His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala Ile Lys Ser 
305                 310                 315                 320 


Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala Glu Gln 
                325                 330                 335     


His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys Ile Glu Leu 
            340                 345                 350         


Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr Val Lys 
        355                 360                 365             


Gly Ile Ala Lys Ser Arg Lys Ser Gly Ser 
    370                 375             


<210> 197
<211> 378
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 197
Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg 
1               5                   10                  15      


Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val 
            20                  25                  30          


Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys 
        35                  40                  45              


Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn 
    50                  55                  60                  


Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile 
65                  70                  75                  80  


Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro 
                85                  90                  95      


Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp 
            100                 105                 110         


Ser Lys Val Gly Gly Asn Lys Asn Tyr Leu Tyr Arg Arg Phe Arg Lys 
        115                 120                 125             


Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln 
    130                 135                 140                 


Ala Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Arg 
145                 150                 155                 160 


Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln 
                165                 170                 175     


Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Arg His Ala Pro Ala 
            180                 185                 190         


Thr Val Cys Gly Pro Gly Ser Gly Gly Gly Gly Glu Ser Gln Val Arg 
        195                 200                 205             


Gln Gln Phe Ser Lys Asp Ile Glu Lys Leu Leu Asn Glu Gln Val Asn 
    210                 215                 220                 


Lys Glu Met Gln Ser Ser Asn Leu Tyr Met Ser Met Ser Ser Trp Cys 
225                 230                 235                 240 


Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp His Ala 
                245                 250                 255     


Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe Leu Asn Glu 
            260                 265                 270         


Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro Glu His Lys 
        275                 280                 285             


Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu His Glu Gln 
    290                 295                 300                 


His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala Ile Lys Ser 
305                 310                 315                 320 


Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala Glu Gln 
                325                 330                 335     


His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys Ile Glu Leu 
            340                 345                 350         


Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr Val Lys 
        355                 360                 365             


Gly Ile Ala Lys Ser Arg Lys Ser Gly Ser 
    370                 375             


<210> 198
<211> 378
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 198
Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg 
1               5                   10                  15      


Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val 
            20                  25                  30          


Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys 
        35                  40                  45              


Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn 
    50                  55                  60                  


Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile 
65                  70                  75                  80  


Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro 
                85                  90                  95      


Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp 
            100                 105                 110         


Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Arg Arg Leu Phe Arg Lys 
        115                 120                 125             


Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln 
    130                 135                 140                 


Ala Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe 
145                 150                 155                 160 


Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln 
                165                 170                 175     


Pro Tyr Arg Val Val Val Leu Ser Phe Glu Asn Lys Ser Ala Pro Ala 
            180                 185                 190         


Thr Val Cys Gly Pro Gly Ser Gly Gly Gly Gly Glu Ser Gln Val Arg 
        195                 200                 205             


Gln Gln Phe Ser Lys Asp Ile Glu Lys Leu Leu Asn Glu Gln Val Asn 
    210                 215                 220                 


Lys Glu Met Gln Ser Ser Asn Leu Tyr Met Ser Met Ser Ser Trp Cys 
225                 230                 235                 240 


Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp His Ala 
                245                 250                 255     


Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe Leu Asn Glu 
            260                 265                 270         


Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro Glu His Lys 
        275                 280                 285             


Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu His Glu Gln 
    290                 295                 300                 


His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala Ile Lys Ser 
305                 310                 315                 320 


Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala Glu Gln 
                325                 330                 335     


His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys Ile Glu Leu 
            340                 345                 350         


Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr Val Lys 
        355                 360                 365             


Gly Ile Ala Lys Ser Arg Lys Ser Gly Ser 
    370                 375             


<210> 199
<211> 378
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 199
Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg 
1               5                   10                  15      


Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val 
            20                  25                  30          


Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys 
        35                  40                  45              


Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn 
    50                  55                  60                  


Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile 
65                  70                  75                  80  


Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro 
                85                  90                  95      


Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp 
            100                 105                 110         


Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Arg Arg Leu Phe Arg Lys 
        115                 120                 125             


Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln 
    130                 135                 140                 


Ala Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe 
145                 150                 155                 160 


Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln 
                165                 170                 175     


Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Arg His Ala Pro Ala 
            180                 185                 190         


Thr Val Cys Gly Pro Gly Ser Gly Gly Gly Gly Glu Ser Gln Val Arg 
        195                 200                 205             


Gln Gln Phe Ser Lys Asp Ile Glu Lys Leu Leu Asn Glu Gln Val Asn 
    210                 215                 220                 


Lys Glu Met Gln Ser Ser Asn Leu Tyr Met Ser Met Ser Ser Trp Cys 
225                 230                 235                 240 


Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp His Ala 
                245                 250                 255     


Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe Leu Asn Glu 
            260                 265                 270         


Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro Glu His Lys 
        275                 280                 285             


Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu His Glu Gln 
    290                 295                 300                 


His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala Ile Lys Ser 
305                 310                 315                 320 


Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala Glu Gln 
                325                 330                 335     


His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys Ile Glu Leu 
            340                 345                 350         


Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr Val Lys 
        355                 360                 365             


Gly Ile Ala Lys Ser Arg Lys Ser Gly Ser 
    370                 375             


<210> 200
<211> 378
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 200
Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg 
1               5                   10                  15      


Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val 
            20                  25                  30          


Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys 
        35                  40                  45              


Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn 
    50                  55                  60                  


Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile 
65                  70                  75                  80  


Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro 
                85                  90                  95      


Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp 
            100                 105                 110         


Ser Lys Val Gly Gly Asn Lys Asn Tyr Leu Tyr Arg Arg Phe Arg Lys 
        115                 120                 125             


Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln 
    130                 135                 140                 


Ala Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Arg 
145                 150                 155                 160 


Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln 
                165                 170                 175     


Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala 
            180                 185                 190         


Thr Val Cys Gly Pro Gly Ser Gly Gly Gly Gly Glu Ser Gln Val Arg 
        195                 200                 205             


Gln Gln Phe Ser Lys Asp Ile Glu Lys Leu Leu Asn Glu Gln Val Asn 
    210                 215                 220                 


Lys Glu Met Gln Ser Ser Asn Leu Tyr Met Ser Met Ser Ser Trp Cys 
225                 230                 235                 240 


Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp His Ala 
                245                 250                 255     


Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe Leu Asn Glu 
            260                 265                 270         


Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro Glu His Lys 
        275                 280                 285             


Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu His Glu Gln 
    290                 295                 300                 


His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala Ile Lys Ser 
305                 310                 315                 320 


Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala Glu Gln 
                325                 330                 335     


His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys Ile Glu Leu 
            340                 345                 350         


Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr Val Lys 
        355                 360                 365             


Gly Ile Ala Lys Ser Arg Lys Ser Gly Ser 
    370                 375             


<210> 201
<211> 378
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 201
Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg 
1               5                   10                  15      


Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val 
            20                  25                  30          


Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys 
        35                  40                  45              


Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn 
    50                  55                  60                  


Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile 
65                  70                  75                  80  


Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro 
                85                  90                  95      


Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp 
            100                 105                 110         


Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Arg Phe Arg Lys 
        115                 120                 125             


Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln 
    130                 135                 140                 


Ala Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe 
145                 150                 155                 160 


Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln 
                165                 170                 175     


Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala 
            180                 185                 190         


Thr Val Cys Gly Pro Gly Ser Gly Gly Gly Gly Glu Ser Gln Val Arg 
        195                 200                 205             


Gln Gln Phe Ser Lys Asp Ile Glu Lys Leu Leu Asn Glu Gln Val Asn 
    210                 215                 220                 


Lys Glu Met Gln Ser Ser Asn Leu Tyr Met Ser Met Ser Ser Trp Cys 
225                 230                 235                 240 


Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp His Ala 
                245                 250                 255     


Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe Leu Asn Glu 
            260                 265                 270         


Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro Glu His Lys 
        275                 280                 285             


Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu His Glu Gln 
    290                 295                 300                 


His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala Ile Lys Ser 
305                 310                 315                 320 


Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala Glu Gln 
                325                 330                 335     


His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys Ile Glu Leu 
            340                 345                 350         


Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr Val Lys 
        355                 360                 365             


Gly Ile Ala Lys Ser Arg Lys Ser Gly Ser 
    370                 375             


<210> 202
<211> 378
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 202
Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg 
1               5                   10                  15      


Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val 
            20                  25                  30          


Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys 
        35                  40                  45              


Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn 
    50                  55                  60                  


Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile 
65                  70                  75                  80  


Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro 
                85                  90                  95      


Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp 
            100                 105                 110         


Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys 
        115                 120                 125             


Ser Asn Leu Lys Pro Phe Glu Arg Asp Arg Ser Thr Glu Ile Tyr Gln 
    130                 135                 140                 


Ala Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe 
145                 150                 155                 160 


Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln 
                165                 170                 175     


Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala 
            180                 185                 190         


Thr Val Cys Gly Pro Gly Ser Gly Gly Gly Gly Glu Ser Gln Val Arg 
        195                 200                 205             


Gln Gln Phe Ser Lys Asp Ile Glu Lys Leu Leu Asn Glu Gln Val Asn 
    210                 215                 220                 


Lys Glu Met Gln Ser Ser Asn Leu Tyr Met Ser Met Ser Ser Trp Cys 
225                 230                 235                 240 


Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp His Ala 
                245                 250                 255     


Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe Leu Asn Glu 
            260                 265                 270         


Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro Glu His Lys 
        275                 280                 285             


Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu His Glu Gln 
    290                 295                 300                 


His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala Ile Lys Ser 
305                 310                 315                 320 


Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala Glu Gln 
                325                 330                 335     


His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys Ile Glu Leu 
            340                 345                 350         


Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr Val Lys 
        355                 360                 365             


Gly Ile Ala Lys Ser Arg Lys Ser Gly Ser 
    370                 375             


<210> 203
<211> 378
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 203
Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg 
1               5                   10                  15      


Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val 
            20                  25                  30          


Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys 
        35                  40                  45              


Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn 
    50                  55                  60                  


Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile 
65                  70                  75                  80  


Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro 
                85                  90                  95      


Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp 
            100                 105                 110         


Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Arg Arg Leu Phe Arg Lys 
        115                 120                 125             


Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln 
    130                 135                 140                 


Ala Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe 
145                 150                 155                 160 


Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln 
                165                 170                 175     


Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala 
            180                 185                 190         


Thr Val Cys Gly Pro Gly Ser Gly Gly Gly Gly Glu Ser Gln Val Arg 
        195                 200                 205             


Gln Gln Phe Ser Lys Asp Ile Glu Lys Leu Leu Asn Glu Gln Val Asn 
    210                 215                 220                 


Lys Glu Met Gln Ser Ser Asn Leu Tyr Met Ser Met Ser Ser Trp Cys 
225                 230                 235                 240 


Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp His Ala 
                245                 250                 255     


Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe Leu Asn Glu 
            260                 265                 270         


Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro Glu His Lys 
        275                 280                 285             


Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu His Glu Gln 
    290                 295                 300                 


His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala Ile Lys Ser 
305                 310                 315                 320 


Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala Glu Gln 
                325                 330                 335     


His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys Ile Glu Leu 
            340                 345                 350         


Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr Val Lys 
        355                 360                 365             


Gly Ile Ala Lys Ser Arg Lys Ser Gly Ser 
    370                 375             


<210> 204
<211> 378
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 204
Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg 
1               5                   10                  15      


Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val 
            20                  25                  30          


Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys 
        35                  40                  45              


Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn 
    50                  55                  60                  


Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile 
65                  70                  75                  80  


Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro 
                85                  90                  95      


Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp 
            100                 105                 110         


Ser Lys Val Gly Gly Asn Tyr Asn Tyr Arg Tyr Arg Leu Phe Arg Lys 
        115                 120                 125             


Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln 
    130                 135                 140                 


Ala Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe 
145                 150                 155                 160 


Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln 
                165                 170                 175     


Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala 
            180                 185                 190         


Thr Val Cys Gly Pro Gly Ser Gly Gly Gly Gly Glu Ser Gln Val Arg 
        195                 200                 205             


Gln Gln Phe Ser Lys Asp Ile Glu Lys Leu Leu Asn Glu Gln Val Asn 
    210                 215                 220                 


Lys Glu Met Gln Ser Ser Asn Leu Tyr Met Ser Met Ser Ser Trp Cys 
225                 230                 235                 240 


Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp His Ala 
                245                 250                 255     


Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe Leu Asn Glu 
            260                 265                 270         


Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro Glu His Lys 
        275                 280                 285             


Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu His Glu Gln 
    290                 295                 300                 


His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala Ile Lys Ser 
305                 310                 315                 320 


Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala Glu Gln 
                325                 330                 335     


His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys Ile Glu Leu 
            340                 345                 350         


Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr Val Lys 
        355                 360                 365             


Gly Ile Ala Lys Ser Arg Lys Ser Gly Ser 
    370                 375             


<210> 205
<211> 378
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 205
Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg 
1               5                   10                  15      


Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val 
            20                  25                  30          


Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys 
        35                  40                  45              


Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn 
    50                  55                  60                  


Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile 
65                  70                  75                  80  


Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro 
                85                  90                  95      


Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp 
            100                 105                 110         


Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys 
        115                 120                 125             


Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln 
    130                 135                 140                 


Ala Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe 
145                 150                 155                 160 


Pro Arg Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln 
                165                 170                 175     


Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala 
            180                 185                 190         


Thr Val Cys Gly Pro Gly Ser Gly Gly Gly Gly Glu Ser Gln Val Arg 
        195                 200                 205             


Gln Gln Phe Ser Lys Asp Ile Glu Lys Leu Leu Asn Glu Gln Val Asn 
    210                 215                 220                 


Lys Glu Met Gln Ser Ser Asn Leu Tyr Met Ser Met Ser Ser Trp Cys 
225                 230                 235                 240 


Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp His Ala 
                245                 250                 255     


Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe Leu Asn Glu 
            260                 265                 270         


Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro Glu His Lys 
        275                 280                 285             


Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu His Glu Gln 
    290                 295                 300                 


His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala Ile Lys Ser 
305                 310                 315                 320 


Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala Glu Gln 
                325                 330                 335     


His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys Ile Glu Leu 
            340                 345                 350         


Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr Val Lys 
        355                 360                 365             


Gly Ile Ala Lys Ser Arg Lys Ser Gly Ser 
    370                 375             


<210> 206
<211> 378
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 206
Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg 
1               5                   10                  15      


Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val 
            20                  25                  30          


Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys 
        35                  40                  45              


Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn 
    50                  55                  60                  


Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile 
65                  70                  75                  80  


Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro 
                85                  90                  95      


Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp 
            100                 105                 110         


Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys 
        115                 120                 125             


Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln 
    130                 135                 140                 


Ala Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Arg 
145                 150                 155                 160 


Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln 
                165                 170                 175     


Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala 
            180                 185                 190         


Thr Val Cys Gly Pro Gly Ser Gly Gly Gly Gly Glu Ser Gln Val Arg 
        195                 200                 205             


Gln Gln Phe Ser Lys Asp Ile Glu Lys Leu Leu Asn Glu Gln Val Asn 
    210                 215                 220                 


Lys Glu Met Gln Ser Ser Asn Leu Tyr Met Ser Met Ser Ser Trp Cys 
225                 230                 235                 240 


Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp His Ala 
                245                 250                 255     


Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe Leu Asn Glu 
            260                 265                 270         


Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro Glu His Lys 
        275                 280                 285             


Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu His Glu Gln 
    290                 295                 300                 


His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala Ile Lys Ser 
305                 310                 315                 320 


Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala Glu Gln 
                325                 330                 335     


His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys Ile Glu Leu 
            340                 345                 350         


Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr Val Lys 
        355                 360                 365             


Gly Ile Ala Lys Ser Arg Lys Ser Gly Ser 
    370                 375             


<210> 207
<211> 378
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 207
Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg 
1               5                   10                  15      


Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val 
            20                  25                  30          


Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys 
        35                  40                  45              


Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn 
    50                  55                  60                  


Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile 
65                  70                  75                  80  


Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro 
                85                  90                  95      


Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp 
            100                 105                 110         


Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys 
        115                 120                 125             


Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln 
    130                 135                 140                 


Ala Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Ala 
145                 150                 155                 160 


Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln 
                165                 170                 175     


Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala 
            180                 185                 190         


Thr Val Cys Gly Pro Gly Ser Gly Gly Gly Gly Glu Ser Gln Val Arg 
        195                 200                 205             


Gln Gln Phe Ser Lys Asp Ile Glu Lys Leu Leu Asn Glu Gln Val Asn 
    210                 215                 220                 


Lys Glu Met Gln Ser Ser Asn Leu Tyr Met Ser Met Ser Ser Trp Cys 
225                 230                 235                 240 


Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp His Ala 
                245                 250                 255     


Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe Leu Asn Glu 
            260                 265                 270         


Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro Glu His Lys 
        275                 280                 285             


Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu His Glu Gln 
    290                 295                 300                 


His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala Ile Lys Ser 
305                 310                 315                 320 


Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala Glu Gln 
                325                 330                 335     


His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys Ile Glu Leu 
            340                 345                 350         


Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr Val Lys 
        355                 360                 365             


Gly Ile Ala Lys Ser Arg Lys Ser Gly Ser 
    370                 375             


<210> 208
<211> 378
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 208
Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg 
1               5                   10                  15      


Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val 
            20                  25                  30          


Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys 
        35                  40                  45              


Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn 
    50                  55                  60                  


Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile 
65                  70                  75                  80  


Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro 
                85                  90                  95      


Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp 
            100                 105                 110         


Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys 
        115                 120                 125             


Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln 
    130                 135                 140                 


Ala Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe 
145                 150                 155                 160 


Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln 
                165                 170                 175     


Pro Tyr Arg Val Val Val Leu Ser Phe Glu Asn Lys Ser Ala Pro Ala 
            180                 185                 190         


Thr Val Cys Gly Pro Gly Ser Gly Gly Gly Gly Glu Ser Gln Val Arg 
        195                 200                 205             


Gln Gln Phe Ser Lys Asp Ile Glu Lys Leu Leu Asn Glu Gln Val Asn 
    210                 215                 220                 


Lys Glu Met Gln Ser Ser Asn Leu Tyr Met Ser Met Ser Ser Trp Cys 
225                 230                 235                 240 


Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp His Ala 
                245                 250                 255     


Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe Leu Asn Glu 
            260                 265                 270         


Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro Glu His Lys 
        275                 280                 285             


Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu His Glu Gln 
    290                 295                 300                 


His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala Ile Lys Ser 
305                 310                 315                 320 


Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala Glu Gln 
                325                 330                 335     


His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys Ile Glu Leu 
            340                 345                 350         


Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr Val Lys 
        355                 360                 365             


Gly Ile Ala Lys Ser Arg Lys Ser Gly Ser 
    370                 375             


<210> 209
<211> 378
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 209
Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg 
1               5                   10                  15      


Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val 
            20                  25                  30          


Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys 
        35                  40                  45              


Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn 
    50                  55                  60                  


Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile 
65                  70                  75                  80  


Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro 
                85                  90                  95      


Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp 
            100                 105                 110         


Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys 
        115                 120                 125             


Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln 
    130                 135                 140                 


Ala Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe 
145                 150                 155                 160 


Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln 
                165                 170                 175     


Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Arg His Ala Pro Ala 
            180                 185                 190         


Thr Val Cys Gly Pro Gly Ser Gly Gly Gly Gly Glu Ser Gln Val Arg 
        195                 200                 205             


Gln Gln Phe Ser Lys Asp Ile Glu Lys Leu Leu Asn Glu Gln Val Asn 
    210                 215                 220                 


Lys Glu Met Gln Ser Ser Asn Leu Tyr Met Ser Met Ser Ser Trp Cys 
225                 230                 235                 240 


Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp His Ala 
                245                 250                 255     


Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe Leu Asn Glu 
            260                 265                 270         


Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro Glu His Lys 
        275                 280                 285             


Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu His Glu Gln 
    290                 295                 300                 


His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala Ile Lys Ser 
305                 310                 315                 320 


Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala Glu Gln 
                325                 330                 335     


His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys Ile Glu Leu 
            340                 345                 350         


Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr Val Lys 
        355                 360                 365             


Gly Ile Ala Lys Ser Arg Lys Ser Gly Ser 
    370                 375             


<210> 210
<211> 378
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 210
Asn Ile Thr Asn Asn Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg 
1               5                   10                  15      


Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val 
            20                  25                  30          


Ala Asp Tyr Ser Thr Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys 
        35                  40                  45              


Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn 
    50                  55                  60                  


Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile 
65                  70                  75                  80  


Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro 
                85                  90                  95      


Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp 
            100                 105                 110         


Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys 
        115                 120                 125             


Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln 
    130                 135                 140                 


Ala Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe 
145                 150                 155                 160 


Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln 
                165                 170                 175     


Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala 
            180                 185                 190         


Thr Val Cys Gly Pro Gly Ser Gly Gly Gly Gly Glu Ser Gln Val Arg 
        195                 200                 205             


Gln Gln Phe Ser Lys Asp Ile Glu Lys Leu Leu Asn Glu Gln Val Asn 
    210                 215                 220                 


Lys Glu Met Gln Ser Ser Asn Leu Tyr Met Ser Met Ser Ser Trp Cys 
225                 230                 235                 240 


Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp His Ala 
                245                 250                 255     


Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe Leu Asn Glu 
            260                 265                 270         


Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro Glu His Lys 
        275                 280                 285             


Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu His Glu Gln 
    290                 295                 300                 


His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala Ile Lys Ser 
305                 310                 315                 320 


Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala Glu Gln 
                325                 330                 335     


His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys Ile Glu Leu 
            340                 345                 350         


Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr Val Lys 
        355                 360                 365             


Gly Ile Ala Lys Ser Arg Lys Ser Gly Ser 
    370                 375             


<210> 211
<211> 378
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 211
Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg 
1               5                   10                  15      


Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val 
            20                  25                  30          


Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys 
        35                  40                  45              


Cys Tyr Gly Val Ser Pro Asn Lys Thr Asn Asp Leu Cys Phe Thr Asn 
    50                  55                  60                  


Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile 
65                  70                  75                  80  


Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro 
                85                  90                  95      


Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp 
            100                 105                 110         


Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys 
        115                 120                 125             


Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln 
    130                 135                 140                 


Ala Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe 
145                 150                 155                 160 


Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln 
                165                 170                 175     


Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala 
            180                 185                 190         


Thr Val Cys Gly Pro Gly Ser Gly Gly Gly Gly Glu Ser Gln Val Arg 
        195                 200                 205             


Gln Gln Phe Ser Lys Asp Ile Glu Lys Leu Leu Asn Glu Gln Val Asn 
    210                 215                 220                 


Lys Glu Met Gln Ser Ser Asn Leu Tyr Met Ser Met Ser Ser Trp Cys 
225                 230                 235                 240 


Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp His Ala 
                245                 250                 255     


Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe Leu Asn Glu 
            260                 265                 270         


Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro Glu His Lys 
        275                 280                 285             


Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu His Glu Gln 
    290                 295                 300                 


His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala Ile Lys Ser 
305                 310                 315                 320 


Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala Glu Gln 
                325                 330                 335     


His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys Ile Glu Leu 
            340                 345                 350         


Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr Val Lys 
        355                 360                 365             


Gly Ile Ala Lys Ser Arg Lys Ser Gly Ser 
    370                 375             


<210> 212
<211> 378
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 212
Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg 
1               5                   10                  15      


Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val 
            20                  25                  30          


Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys 
        35                  40                  45              


Cys Tyr Gly Arg Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn 
    50                  55                  60                  


Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile 
65                  70                  75                  80  


Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro 
                85                  90                  95      


Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp 
            100                 105                 110         


Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys 
        115                 120                 125             


Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln 
    130                 135                 140                 


Ala Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe 
145                 150                 155                 160 


Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln 
                165                 170                 175     


Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala 
            180                 185                 190         


Thr Val Cys Gly Pro Gly Ser Gly Gly Gly Gly Glu Ser Gln Val Arg 
        195                 200                 205             


Gln Gln Phe Ser Lys Asp Ile Glu Lys Leu Leu Asn Glu Gln Val Asn 
    210                 215                 220                 


Lys Glu Met Gln Ser Ser Asn Leu Tyr Met Ser Met Ser Ser Trp Cys 
225                 230                 235                 240 


Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp His Ala 
                245                 250                 255     


Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe Leu Asn Glu 
            260                 265                 270         


Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro Glu His Lys 
        275                 280                 285             


Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu His Glu Gln 
    290                 295                 300                 


His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala Ile Lys Ser 
305                 310                 315                 320 


Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala Glu Gln 
                325                 330                 335     


His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys Ile Glu Leu 
            340                 345                 350         


Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr Val Lys 
        355                 360                 365             


Gly Ile Ala Lys Ser Arg Lys Ser Gly Ser 
    370                 375             


<210> 213
<211> 378
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 213
Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg 
1               5                   10                  15      


Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val 
            20                  25                  30          


Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Arg Lys 
        35                  40                  45              


Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn 
    50                  55                  60                  


Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile 
65                  70                  75                  80  


Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro 
                85                  90                  95      


Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp 
            100                 105                 110         


Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys 
        115                 120                 125             


Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln 
    130                 135                 140                 


Ala Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe 
145                 150                 155                 160 


Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln 
                165                 170                 175     


Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala 
            180                 185                 190         


Thr Val Cys Gly Pro Gly Ser Gly Gly Gly Gly Glu Ser Gln Val Arg 
        195                 200                 205             


Gln Gln Phe Ser Lys Asp Ile Glu Lys Leu Leu Asn Glu Gln Val Asn 
    210                 215                 220                 


Lys Glu Met Gln Ser Ser Asn Leu Tyr Met Ser Met Ser Ser Trp Cys 
225                 230                 235                 240 


Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp His Ala 
                245                 250                 255     


Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe Leu Asn Glu 
            260                 265                 270         


Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro Glu His Lys 
        275                 280                 285             


Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu His Glu Gln 
    290                 295                 300                 


His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala Ile Lys Ser 
305                 310                 315                 320 


Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala Glu Gln 
                325                 330                 335     


His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys Ile Glu Leu 
            340                 345                 350         


Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr Val Lys 
        355                 360                 365             


Gly Ile Ala Lys Ser Arg Lys Ser Gly Ser 
    370                 375             


<210> 214
<211> 482
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 214
Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe 
1               5                   10                  15      


Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala 
            20                  25                  30          


Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys 
        35                  40                  45              


Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val 
    50                  55                  60                  


Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala 
65                  70                  75                  80  


Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp 
                85                  90                  95      


Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser 
            100                 105                 110         


Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser 
        115                 120                 125             


Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala 
    130                 135                 140                 


Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro 
145                 150                 155                 160 


Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro 
                165                 170                 175     


Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr 
            180                 185                 190         


Val Cys Gly Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Pro Lys 
        195                 200                 205             


Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
    210                 215                 220                 


Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
225                 230                 235                 240 


Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 
                245                 250                 255     


Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Ala 
            260                 265                 270         


Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe 
        275                 280                 285             


Arg Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe 
    290                 295                 300                 


Ser Asn Val Thr Trp Phe His Asp Asn Pro Val Leu Pro Phe Asn Asp 
305                 310                 315                 320 


Gly Val Tyr Phe Ala Ser Thr Asn Ile Ile Arg Gly Trp Ile Phe Gly 
                325                 330                 335     


Thr Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala 
            340                 345                 350         


Thr Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro 
        355                 360                 365             


Phe Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val 
    370                 375                 380                 


Ser Gln Pro Phe Leu Lys Asn Leu Arg Glu Phe Val Phe Lys Asn Ile 
385                 390                 395                 400 


Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr Pro Ile Asn Leu Val 
                405                 410                 415     


Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu Pro Leu Val Asp Leu 
            420                 425                 430         


Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr Leu Leu Ala Leu His 
        435                 440                 445             


Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro Arg Thr Phe Leu 
    450                 455                 460                 


Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala Val Asp Cys Ala 
465                 470                 475                 480 


Leu Asp 
        


<210> 215
<211> 613
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 215
Lys Pro Ser Gly Ser Val Val Glu Gln Ala Glu Gly Val Glu Cys Asp 
1               5                   10                  15      


Phe Ser Pro Leu Leu Ser Gly Thr Pro Pro Gln Val Tyr Asn Phe Lys 
            20                  25                  30          


Arg Leu Val Phe Thr Asn Cys Asn Tyr Asn Leu Thr Lys Leu Leu Ser 
        35                  40                  45              


Leu Phe Ser Val Asn Asp Phe Thr Cys Ser Gln Ile Ser Pro Ala Ala 
    50                  55                  60                  


Ile Ala Ser Asn Cys Tyr Ser Ser Leu Ile Leu Asp Tyr Phe Ser Tyr 
65                  70                  75                  80  


Pro Leu Ser Met Lys Ser Asp Leu Ser Val Ser Ser Ala Gly Pro Ile 
                85                  90                  95      


Ser Gln Phe Asn Tyr Lys Gln Ser Phe Ser Asn Pro Thr Cys Leu Ile 
            100                 105                 110         


Leu Ala Thr Val Pro His Asn Leu Thr Thr Ile Thr Lys Pro Leu Lys 
        115                 120                 125             


Tyr Ser Tyr Ile Asn Lys Cys Ser Arg Leu Leu Ser Asp Asp Arg Thr 
    130                 135                 140                 


Glu Val Pro Gln Leu Val Asn Ala Asn Gln Tyr Ser Pro Cys Val Ser 
145                 150                 155                 160 


Ile Val Pro Ser Thr Val Trp Glu Asp Gly Asp Tyr Tyr Arg Lys Gln 
                165                 170                 175     


Leu Ser Pro Leu Glu Gly Gly Gly Trp Leu Val Ala Ser Gly Ser Thr 
            180                 185                 190         


Val Ala Met Thr Glu Gln Leu Gln Met Gly Phe Gly Ile Thr Val Gln 
        195                 200                 205             


Tyr Gly Thr Asp Thr Asn Ser Val Cys Pro Lys Leu Glu Phe Ala Asn 
    210                 215                 220                 


Asp Thr Lys Ile Ala Ser Gln Leu Gly Asn Cys Val Glu Tyr Ser Leu 
225                 230                 235                 240 


Tyr Gly Val Ser Gly Arg Gly Val Phe Gln Asn Cys Thr Ala Val Gly 
                245                 250                 255     


Val Arg Gln Gln Arg Phe Val Tyr Asp Ala Tyr Gln Asn Leu Val Gly 
            260                 265                 270         


Tyr Tyr Ser Asp Asp Gly Asn Tyr Val Asp Val Gly Pro Asp Ser Val 
        275                 280                 285             


Lys Ser Ala Cys Ile Glu Val Asp Ile Gln Gln Thr Phe Phe Asp Lys 
    290                 295                 300                 


Thr Trp Pro Arg Pro Ile Asp Val Ser Lys Ala Asp Gly Ile Ile Tyr 
305                 310                 315                 320 


Pro Gln Gly Arg Thr Tyr Ser Asn Ile Thr Ile Thr Tyr Gln Gly Leu 
                325                 330                 335     


Phe Pro Tyr Gln Gly Asp His Gly Asp Met Tyr Val Tyr Ser Ala Gly 
            340                 345                 350         


His Ala Thr Gly Thr Thr Pro Gln Lys Leu Phe Val Ala Asn Tyr Ser 
        355                 360                 365             


Gln Asp Val Lys Gln Phe Ala Asn Gly Phe Val Val Arg Ile Gly Ala 
    370                 375                 380                 


Ala Ala Asn Ser Thr Gly Thr Val Ile Ile Ser Pro Ser Thr Ser Ala 
385                 390                 395                 400 


Thr Ile Arg Lys Ile Tyr Pro Ala Phe Met Leu Gly Ser Ser Val Gly 
                405                 410                 415     


Asn Phe Ser Asp Gly Lys Met Gly Arg Phe Phe Asn His Thr Leu Val 
            420                 425                 430         


Leu Leu Pro Asp Gly Cys Gly Thr Leu Leu Arg Ala Phe Tyr Cys Ile 
        435                 440                 445             


Leu Glu Pro Arg Ser Gly Asn His Cys Pro Ala Gly Asn Ser Tyr Thr 
    450                 455                 460                 


Ser Phe Ala Thr Tyr His Thr Pro Ala Thr Asp Cys Ser Asp Gly Asn 
465                 470                 475                 480 


Tyr Asn Arg Asn Ala Ser Leu Asn Ser Phe Lys Glu Tyr Phe Asn Leu 
                485                 490                 495     


Arg Asn Cys Thr Phe Met Tyr Thr Tyr Asn Ile Thr Glu Asp Glu Ile 
            500                 505                 510         


Leu Glu Trp Phe Gly Ile Thr Gln Thr Ala Gln Gly Val His Leu Phe 
        515                 520                 525             


Ser Ser Arg Tyr Val Asp Leu Tyr Gly Gly Asn Met Phe Gln Phe Ala 
    530                 535                 540                 


Thr Leu Pro Val Tyr Asp Thr Ile Lys Tyr Tyr Ser Ile Ile Pro His 
545                 550                 555                 560 


Ser Ile Arg Ser Ile Gln Ser Asp Arg Lys Ala Trp Ala Ala Phe Tyr 
                565                 570                 575     


Val Tyr Lys Leu Gln Pro Leu Thr Phe Leu Leu Asp Phe Ser Val Asp 
            580                 585                 590         


Gly Tyr Ile Arg Arg Ala Ile Asp Cys Gly Phe Asn Asp Leu Ser Gln 
        595                 600                 605             


Leu His Cys Ser Tyr 
    610             


<210> 216
<211> 531
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 216
Arg Val Val Pro Ser Gly Asp Val Val Arg Phe Pro Asn Ile Thr Asn 
1               5                   10                  15      


Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Lys Phe Pro Ser Val 
            20                  25                  30          


Tyr Ala Trp Glu Arg Lys Lys Ile Ser Asn Cys Val Ala Asp Tyr Ser 
        35                  40                  45              


Val Leu Tyr Asn Ser Thr Phe Phe Ser Thr Phe Lys Cys Tyr Gly Val 
    50                  55                  60                  


Ser Ala Thr Lys Leu Asn Asp Leu Cys Phe Ser Asn Val Tyr Ala Asp 
65                  70                  75                  80  


Ser Phe Val Val Lys Gly Asp Asp Val Arg Gln Ile Ala Pro Gly Gln 
                85                  90                  95      


Thr Gly Val Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Met 
            100                 105                 110         


Gly Cys Val Leu Ala Trp Asn Thr Arg Asn Ile Asp Ala Thr Ser Thr 
        115                 120                 125             


Gly Asn Tyr Asn Tyr Lys Tyr Arg Tyr Leu Arg His Gly Lys Leu Arg 
    130                 135                 140                 


Pro Phe Glu Arg Asp Ile Ser Asn Val Pro Phe Ser Pro Asp Gly Lys 
145                 150                 155                 160 


Pro Cys Thr Pro Pro Ala Leu Asn Cys Tyr Trp Pro Leu Asn Asp Tyr 
                165                 170                 175     


Gly Phe Tyr Thr Thr Thr Gly Ile Gly Tyr Gln Pro Tyr Arg Val Val 
            180                 185                 190         


Val Leu Ser Phe Glu Leu Leu Asn Ala Pro Ala Thr Val Cys Gly Pro 
        195                 200                 205             


Lys Leu Ser Thr Asp Leu Ile Lys Asn Gln Cys Val Asn Phe Asn Phe 
    210                 215                 220                 


Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Pro Ser Ser Lys Arg Phe 
225                 230                 235                 240 


Gln Pro Phe Gln Gln Phe Gly Arg Asp Val Ser Asp Phe Thr Asp Ser 
                245                 250                 255     


Val Arg Asp Pro Lys Thr Ser Glu Ile Leu Asp Ile Ser Pro Cys Ser 
            260                 265                 270         


Arg Cys Thr Thr Phe Asp Asp Val Gln Ala Pro Asn Tyr Thr Gln His 
        275                 280                 285             


Thr Ser Ser Met Arg Gly Val Tyr Tyr Pro Asp Glu Ile Phe Arg Ser 
    290                 295                 300                 


Asp Thr Leu Tyr Leu Thr Gln Asp Leu Phe Leu Pro Phe Tyr Ser Asn 
305                 310                 315                 320 


Val Thr Gly Phe His Thr Ile Asn His Thr Phe Asp Asn Pro Val Ile 
                325                 330                 335     


Pro Phe Lys Asp Gly Ile Tyr Phe Ala Ala Thr Glu Lys Ser Asn Val 
            340                 345                 350         


Val Arg Gly Trp Val Phe Gly Ser Thr Met Asn Asn Lys Ser Gln Ser 
        355                 360                 365             


Val Ile Ile Ile Asn Asn Ser Thr Asn Val Val Ile Arg Ala Cys Asn 
    370                 375                 380                 


Phe Glu Leu Cys Asp Asn Pro Phe Phe Ala Val Ser Lys Pro Met Gly 
385                 390                 395                 400 


Thr Gln Thr His Thr Met Ile Phe Asp Asn Ala Phe Asn Cys Thr Phe 
                405                 410                 415     


Glu Tyr Ile Ser Asp Ala Phe Ser Leu Asp Val Ser Glu Lys Ser Gly 
            420                 425                 430         


Asn Phe Lys His Leu Arg Glu Phe Val Phe Lys Asn Lys Asp Gly Phe 
        435                 440                 445             


Leu Tyr Val Tyr Lys Gly Tyr Gln Pro Ile Asp Val Val Arg Asp Leu 
    450                 455                 460                 


Pro Ser Gly Phe Asn Thr Leu Lys Pro Ile Phe Lys Leu Pro Leu Gly 
465                 470                 475                 480 


Ile Asn Ile Thr Asn Phe Arg Ala Ile Leu Thr Ala Phe Ser Thr Trp 
                485                 490                 495     


Gly Thr Ser Ala Ala Ala Tyr Phe Val Gly Tyr Leu Lys Pro Thr Thr 
            500                 505                 510         


Phe Met Leu Lys Tyr Asp Glu Asn Gly Thr Ile Thr Asp Ala Val Asp 
        515                 520                 525             


Cys Ser Gln 
    530     


<210> 217
<211> 396
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 217
His His His His His His His His Gly Pro Leu Glu Val Leu Phe Gln 
1               5                   10                  15      


Gly Pro Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala 
            20                  25                  30          


Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn 
        35                  40                  45              


Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr 
    50                  55                  60                  


Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe 
65                  70                  75                  80  


Thr Asn Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg 
                85                  90                  95      


Gln Ile Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys 
            100                 105                 110         


Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn 
        115                 120                 125             


Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Arg Arg Leu Phe 
    130                 135                 140                 


Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile 
145                 150                 155                 160 


Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys 
                165                 170                 175     


Tyr Phe Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Tyr Gly Val Gly 
            180                 185                 190         


Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe Glu Asn Lys Ser Ala 
        195                 200                 205             


Pro Ala Thr Val Cys Gly Pro Gly Ser Gly Gly Gly Gly Glu Ser Gln 
    210                 215                 220                 


Val Arg Gln Gln Phe Ser Lys Asp Ile Glu Lys Leu Leu Asn Glu Gln 
225                 230                 235                 240 


Val Asn Lys Glu Met Gln Ser Ser Asn Leu Tyr Met Ser Met Ser Ser 
                245                 250                 255     


Trp Cys Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp 
            260                 265                 270         


His Ala Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe Leu 
        275                 280                 285             


Asn Glu Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro Glu 
    290                 295                 300                 


His Lys Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu His 
305                 310                 315                 320 


Glu Gln His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala Ile 
                325                 330                 335     


Lys Ser Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala 
            340                 345                 350         


Glu Gln His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys Ile 
        355                 360                 365             


Glu Leu Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr 
    370                 375                 380                 


Val Lys Gly Ile Ala Lys Ser Arg Lys Ser Gly Ser 
385                 390                 395     


<210> 218
<211> 396
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 218
His His His His His His His His Gly Pro Leu Glu Val Leu Phe Gln 
1               5                   10                  15      


Gly Pro Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala 
            20                  25                  30          


Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn 
        35                  40                  45              


Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr 
    50                  55                  60                  


Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe 
65                  70                  75                  80  


Thr Asn Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg 
                85                  90                  95      


Gln Ile Ala Pro Gly Gln Thr Gly Asn Ile Ala Asp Tyr Asn Tyr Lys 
            100                 105                 110         


Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn 
        115                 120                 125             


Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Arg Arg Leu Phe 
    130                 135                 140                 


Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile 
145                 150                 155                 160 


Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly Val Lys Gly Phe Asn Cys 
                165                 170                 175     


Tyr Phe Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Tyr Gly Val Gly 
            180                 185                 190         


Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe Glu Asn Lys Ser Ala 
        195                 200                 205             


Pro Ala Thr Val Cys Gly Pro Gly Ser Gly Gly Gly Gly Glu Ser Gln 
    210                 215                 220                 


Val Arg Gln Gln Phe Ser Lys Asp Ile Glu Lys Leu Leu Asn Glu Gln 
225                 230                 235                 240 


Val Asn Lys Glu Met Gln Ser Ser Asn Leu Tyr Met Ser Met Ser Ser 
                245                 250                 255     


Trp Cys Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp 
            260                 265                 270         


His Ala Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe Leu 
        275                 280                 285             


Asn Glu Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro Glu 
    290                 295                 300                 


His Lys Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu His 
305                 310                 315                 320 


Glu Gln His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala Ile 
                325                 330                 335     


Lys Ser Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala 
            340                 345                 350         


Glu Gln His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys Ile 
        355                 360                 365             


Glu Leu Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr 
    370                 375                 380                 


Val Lys Gly Ile Ala Lys Ser Arg Lys Ser Gly Ser 
385                 390                 395     


<210> 219
<211> 396
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 219
His His His His His His His His Gly Pro Leu Glu Val Leu Phe Gln 
1               5                   10                  15      


Gly Pro Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala 
            20                  25                  30          


Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn 
        35                  40                  45              


Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr 
    50                  55                  60                  


Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe 
65                  70                  75                  80  


Thr Asn Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg 
                85                  90                  95      


Gln Ile Ala Pro Gly Gln Thr Gly Thr Ile Ala Asp Tyr Asn Tyr Lys 
            100                 105                 110         


Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn 
        115                 120                 125             


Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Arg Arg Leu Phe 
    130                 135                 140                 


Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile 
145                 150                 155                 160 


Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly Val Lys Gly Phe Asn Cys 
                165                 170                 175     


Tyr Phe Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Tyr Gly Val Gly 
            180                 185                 190         


Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe Glu Asn Lys Ser Ala 
        195                 200                 205             


Pro Ala Thr Val Cys Gly Pro Gly Ser Gly Gly Gly Gly Glu Ser Gln 
    210                 215                 220                 


Val Arg Gln Gln Phe Ser Lys Asp Ile Glu Lys Leu Leu Asn Glu Gln 
225                 230                 235                 240 


Val Asn Lys Glu Met Gln Ser Ser Asn Leu Tyr Met Ser Met Ser Ser 
                245                 250                 255     


Trp Cys Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp 
            260                 265                 270         


His Ala Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe Leu 
        275                 280                 285             


Asn Glu Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro Glu 
    290                 295                 300                 


His Lys Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu His 
305                 310                 315                 320 


Glu Gln His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala Ile 
                325                 330                 335     


Lys Ser Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala 
            340                 345                 350         


Glu Gln His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys Ile 
        355                 360                 365             


Glu Leu Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr 
    370                 375                 380                 


Val Lys Gly Ile Ala Lys Ser Arg Lys Ser Gly Ser 
385                 390                 395     


<210> 220
<211> 853
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 220
Ser Ser Gln Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala 
1               5                   10                  15      


Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe 
            20                  25                  30          


Arg Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe 
        35                  40                  45              


Ser Asn Val Thr Trp Phe His Ala Ile Ser Gly Thr Asn Gly Thr Lys 
    50                  55                  60                  


Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala 
65                  70                  75                  80  


Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr 
                85                  90                  95      


Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn 
            100                 105                 110         


Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu 
        115                 120                 125             


Gly Val Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg 
    130                 135                 140                 


Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro 
145                 150                 155                 160 


Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg 
                165                 170                 175     


Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys 
            180                 185                 190         


His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala 
        195                 200                 205             


Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe 
    210                 215                 220                 


Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser 
225                 230                 235                 240 


Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu 
                245                 250                 255     


Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr 
            260                 265                 270         


Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr 
        275                 280                 285             


Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe 
    290                 295                 300                 


Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn 
305                 310                 315                 320 


Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val 
                325                 330                 335     


Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser 
            340                 345                 350         


Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val 
        355                 360                 365             


Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp 
    370                 375                 380                 


Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln 
385                 390                 395                 400 


Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr 
                405                 410                 415     


Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly 
            420                 425                 430         


Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys 
        435                 440                 445             


Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr 
    450                 455                 460                 


Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser 
465                 470                 475                 480 


Tyr Gly Phe Gln Pro Thr Tyr Gly Val Gly Tyr Gln Pro Tyr Arg Val 
                485                 490                 495     


Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly 
            500                 505                 510         


Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn 
        515                 520                 525             


Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys 
    530                 535                 540                 


Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Asp Asp Thr Thr Asp 
545                 550                 555                 560 


Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys 
                565                 570                 575     


Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn 
            580                 585                 590         


Gln Val Ala Val Leu Tyr Gln Gly Val Asn Cys Thr Glu Val Pro Val 
        595                 600                 605             


Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr 
    610                 615                 620                 


Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu 
625                 630                 635                 640 


His Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile 
                645                 650                 655     


Cys Ala Ser Tyr Gln Thr Gly Gly Ser Gln Ser Ile Ile Ala Tyr Thr 
            660                 665                 670         


Gly Ser Gly Gly Gly Gly Glu Ser Gln Val Arg Gln Gln Phe Ser Lys 
        675                 680                 685             


Asp Ile Glu Lys Leu Leu Asn Glu Gln Val Asn Lys Glu Met Gln Ser 
    690                 695                 700                 


Ser Asn Leu Tyr Met Ser Met Ser Ser Trp Cys Tyr Thr His Ser Leu 
705                 710                 715                 720 


Asp Gly Ala Gly Leu Phe Leu Phe Asp His Ala Ala Glu Glu Tyr Glu 
                725                 730                 735     


His Ala Lys Lys Leu Ile Ile Phe Leu Asn Glu Asn Asn Val Pro Val 
            740                 745                 750         


Gln Leu Thr Ser Ile Ser Ala Pro Glu His Lys Phe Glu Gly Leu Thr 
        755                 760                 765             


Gln Ile Phe Gln Lys Ala Tyr Glu His Glu Gln His Ile Ser Glu Ser 
    770                 775                 780                 


Ile Asn Asn Ile Val Asp His Ala Ile Lys Ser Lys Asp His Ala Thr 
785                 790                 795                 800 


Phe Asn Phe Leu Gln Trp Tyr Val Ala Glu Gln His Glu Glu Glu Val 
                805                 810                 815     


Leu Phe Lys Asp Ile Leu Asp Lys Ile Glu Leu Ile Gly Asn Glu Asn 
            820                 825                 830         


His Gly Leu Tyr Leu Ala Asp Gln Tyr Val Lys Gly Ile Ala Lys Ser 
        835                 840                 845             


Arg Lys Ser Gly Ser 
    850             


<210> 221
<211> 853
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 221
Ser Ser Gln Cys Val Asn Phe Thr Thr Arg Thr Gln Leu Pro Pro Ala 
1               5                   10                  15      


Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe 
            20                  25                  30          


Arg Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe 
        35                  40                  45              


Ser Asn Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly 
    50                  55                  60                  


Thr Lys Arg Phe Ala Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr 
65                  70                  75                  80  


Phe Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly 
                85                  90                  95      


Thr Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala 
            100                 105                 110         


Thr Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro 
        115                 120                 125             


Phe Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser 
    130                 135                 140                 


Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val 
145                 150                 155                 160 


Ser Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys 
                165                 170                 175     


Asn Leu Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile 
            180                 185                 190         


Tyr Ser Lys His Thr Pro Ile Asn Leu Val Arg Gly Leu Pro Gln Gly 
        195                 200                 205             


Phe Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile 
    210                 215                 220                 


Thr Arg Phe Gln Thr Leu His Ile Ser Tyr Leu Thr Pro Gly Asp Ser 
225                 230                 235                 240 


Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu 
                245                 250                 255     


Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr 
            260                 265                 270         


Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr 
        275                 280                 285             


Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe 
    290                 295                 300                 


Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn 
305                 310                 315                 320 


Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val 
                325                 330                 335     


Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser 
            340                 345                 350         


Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val 
        355                 360                 365             


Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp 
    370                 375                 380                 


Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln 
385                 390                 395                 400 


Thr Gly Asn Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr 
                405                 410                 415     


Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly 
            420                 425                 430         


Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys 
        435                 440                 445             


Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr 
    450                 455                 460                 


Pro Cys Asn Gly Val Lys Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser 
465                 470                 475                 480 


Tyr Gly Phe Gln Pro Thr Tyr Gly Val Gly Tyr Gln Pro Tyr Arg Val 
                485                 490                 495     


Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly 
            500                 505                 510         


Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn 
        515                 520                 525             


Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys 
    530                 535                 540                 


Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp 
545                 550                 555                 560 


Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys 
                565                 570                 575     


Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn 
            580                 585                 590         


Gln Val Ala Val Leu Tyr Gln Gly Val Asn Cys Thr Glu Val Pro Val 
        595                 600                 605             


Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr 
    610                 615                 620                 


Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu 
625                 630                 635                 640 


His Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile 
                645                 650                 655     


Cys Ala Ser Tyr Gln Thr Gly Gly Ser Gln Ser Ile Ile Ala Tyr Thr 
            660                 665                 670         


Gly Ser Gly Gly Gly Gly Glu Ser Gln Val Arg Gln Gln Phe Ser Lys 
        675                 680                 685             


Asp Ile Glu Lys Leu Leu Asn Glu Gln Val Asn Lys Glu Met Gln Ser 
    690                 695                 700                 


Ser Asn Leu Tyr Met Ser Met Ser Ser Trp Cys Tyr Thr His Ser Leu 
705                 710                 715                 720 


Asp Gly Ala Gly Leu Phe Leu Phe Asp His Ala Ala Glu Glu Tyr Glu 
                725                 730                 735     


His Ala Lys Lys Leu Ile Ile Phe Leu Asn Glu Asn Asn Val Pro Val 
            740                 745                 750         


Gln Leu Thr Ser Ile Ser Ala Pro Glu His Lys Phe Glu Gly Leu Thr 
        755                 760                 765             


Gln Ile Phe Gln Lys Ala Tyr Glu His Glu Gln His Ile Ser Glu Ser 
    770                 775                 780                 


Ile Asn Asn Ile Val Asp His Ala Ile Lys Ser Lys Asp His Ala Thr 
785                 790                 795                 800 


Phe Asn Phe Leu Gln Trp Tyr Val Ala Glu Gln His Glu Glu Glu Val 
                805                 810                 815     


Leu Phe Lys Asp Ile Leu Asp Lys Ile Glu Leu Ile Gly Asn Glu Asn 
            820                 825                 830         


His Gly Leu Tyr Leu Ala Asp Gln Tyr Val Lys Gly Ile Ala Lys Ser 
        835                 840                 845             


Arg Lys Ser Gly Ser 
    850             


<210> 222
<211> 853
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 222
Ser Ser Gln Cys Val Asn Phe Thr Thr Arg Thr Gln Leu Pro Pro Ala 
1               5                   10                  15      


Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe 
            20                  25                  30          


Arg Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe 
        35                  40                  45              


Ser Asn Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly 
    50                  55                  60                  


Thr Lys Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr 
65                  70                  75                  80  


Phe Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly 
                85                  90                  95      


Thr Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala 
            100                 105                 110         


Thr Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro 
        115                 120                 125             


Phe Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser 
    130                 135                 140                 


Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val 
145                 150                 155                 160 


Ser Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys 
                165                 170                 175     


Asn Leu Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile 
            180                 185                 190         


Tyr Ser Lys His Thr Pro Ile Asn Leu Val Arg Gly Leu Pro Gln Gly 
        195                 200                 205             


Phe Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile 
    210                 215                 220                 


Thr Arg Phe Gln Thr Leu His Ile Ser Tyr Leu Thr Pro Gly Asp Ser 
225                 230                 235                 240 


Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu 
                245                 250                 255     


Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr 
            260                 265                 270         


Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr 
        275                 280                 285             


Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe 
    290                 295                 300                 


Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn 
305                 310                 315                 320 


Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val 
                325                 330                 335     


Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser 
            340                 345                 350         


Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val 
        355                 360                 365             


Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp 
    370                 375                 380                 


Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln 
385                 390                 395                 400 


Thr Gly Asn Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr 
                405                 410                 415     


Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly 
            420                 425                 430         


Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys 
        435                 440                 445             


Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr 
    450                 455                 460                 


Pro Cys Asn Gly Val Lys Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser 
465                 470                 475                 480 


Tyr Gly Phe Gln Pro Thr Tyr Gly Val Gly Tyr Gln Pro Tyr Arg Val 
                485                 490                 495     


Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly 
            500                 505                 510         


Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn 
        515                 520                 525             


Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys 
    530                 535                 540                 


Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp 
545                 550                 555                 560 


Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys 
                565                 570                 575     


Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn 
            580                 585                 590         


Gln Val Ala Val Leu Tyr Gln Gly Val Asn Cys Thr Glu Val Pro Val 
        595                 600                 605             


Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr 
    610                 615                 620                 


Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu 
625                 630                 635                 640 


His Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile 
                645                 650                 655     


Cys Ala Ser Tyr Gln Thr Gly Gly Ser Gln Ser Ile Ile Ala Tyr Thr 
            660                 665                 670         


Gly Ser Gly Gly Gly Gly Glu Ser Gln Val Arg Gln Gln Phe Ser Lys 
        675                 680                 685             


Asp Ile Glu Lys Leu Leu Asn Glu Gln Val Asn Lys Glu Met Gln Ser 
    690                 695                 700                 


Ser Asn Leu Tyr Met Ser Met Ser Ser Trp Cys Tyr Thr His Ser Leu 
705                 710                 715                 720 


Asp Gly Ala Gly Leu Phe Leu Phe Asp His Ala Ala Glu Glu Tyr Glu 
                725                 730                 735     


His Ala Lys Lys Leu Ile Ile Phe Leu Asn Glu Asn Asn Val Pro Val 
            740                 745                 750         


Gln Leu Thr Ser Ile Ser Ala Pro Glu His Lys Phe Glu Gly Leu Thr 
        755                 760                 765             


Gln Ile Phe Gln Lys Ala Tyr Glu His Glu Gln His Ile Ser Glu Ser 
    770                 775                 780                 


Ile Asn Asn Ile Val Asp His Ala Ile Lys Ser Lys Asp His Ala Thr 
785                 790                 795                 800 


Phe Asn Phe Leu Gln Trp Tyr Val Ala Glu Gln His Glu Glu Glu Val 
                805                 810                 815     


Leu Phe Lys Asp Ile Leu Asp Lys Ile Glu Leu Ile Gly Asn Glu Asn 
            820                 825                 830         


His Gly Leu Tyr Leu Ala Asp Gln Tyr Val Lys Gly Ile Ala Lys Ser 
        835                 840                 845             


Arg Lys Ser Gly Ser 
    850             


<210> 223
<211> 853
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 223
Ser Ser Gln Cys Val Asn Phe Thr Thr Arg Thr Gln Leu Pro Pro Ala 
1               5                   10                  15      


Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe 
            20                  25                  30          


Arg Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe 
        35                  40                  45              


Ser Asn Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly 
    50                  55                  60                  


Thr Lys Arg Phe Ala Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr 
65                  70                  75                  80  


Phe Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly 
                85                  90                  95      


Thr Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala 
            100                 105                 110         


Thr Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro 
        115                 120                 125             


Phe Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser 
    130                 135                 140                 


Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val 
145                 150                 155                 160 


Ser Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys 
                165                 170                 175     


Asn Leu Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile 
            180                 185                 190         


Tyr Ser Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly 
        195                 200                 205             


Phe Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile 
    210                 215                 220                 


Thr Arg Phe Gln Thr Leu His Ile Ser Tyr Leu Thr Pro Gly Asp Ser 
225                 230                 235                 240 


Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu 
                245                 250                 255     


Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr 
            260                 265                 270         


Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr 
        275                 280                 285             


Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe 
    290                 295                 300                 


Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn 
305                 310                 315                 320 


Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val 
                325                 330                 335     


Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser 
            340                 345                 350         


Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val 
        355                 360                 365             


Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp 
    370                 375                 380                 


Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln 
385                 390                 395                 400 


Thr Gly Asn Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr 
                405                 410                 415     


Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly 
            420                 425                 430         


Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys 
        435                 440                 445             


Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr 
    450                 455                 460                 


Pro Cys Asn Gly Val Lys Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser 
465                 470                 475                 480 


Tyr Gly Phe Gln Pro Thr Tyr Gly Val Gly Tyr Gln Pro Tyr Arg Val 
                485                 490                 495     


Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly 
            500                 505                 510         


Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn 
        515                 520                 525             


Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys 
    530                 535                 540                 


Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp 
545                 550                 555                 560 


Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys 
                565                 570                 575     


Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn 
            580                 585                 590         


Gln Val Ala Val Leu Tyr Gln Gly Val Asn Cys Thr Glu Val Pro Val 
        595                 600                 605             


Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr 
    610                 615                 620                 


Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu 
625                 630                 635                 640 


His Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile 
                645                 650                 655     


Cys Ala Ser Tyr Gln Thr Gly Gly Ser Gln Ser Ile Ile Ala Tyr Thr 
            660                 665                 670         


Gly Ser Gly Gly Gly Gly Glu Ser Gln Val Arg Gln Gln Phe Ser Lys 
        675                 680                 685             


Asp Ile Glu Lys Leu Leu Asn Glu Gln Val Asn Lys Glu Met Gln Ser 
    690                 695                 700                 


Ser Asn Leu Tyr Met Ser Met Ser Ser Trp Cys Tyr Thr His Ser Leu 
705                 710                 715                 720 


Asp Gly Ala Gly Leu Phe Leu Phe Asp His Ala Ala Glu Glu Tyr Glu 
                725                 730                 735     


His Ala Lys Lys Leu Ile Ile Phe Leu Asn Glu Asn Asn Val Pro Val 
            740                 745                 750         


Gln Leu Thr Ser Ile Ser Ala Pro Glu His Lys Phe Glu Gly Leu Thr 
        755                 760                 765             


Gln Ile Phe Gln Lys Ala Tyr Glu His Glu Gln His Ile Ser Glu Ser 
    770                 775                 780                 


Ile Asn Asn Ile Val Asp His Ala Ile Lys Ser Lys Asp His Ala Thr 
785                 790                 795                 800 


Phe Asn Phe Leu Gln Trp Tyr Val Ala Glu Gln His Glu Glu Glu Val 
                805                 810                 815     


Leu Phe Lys Asp Ile Leu Asp Lys Ile Glu Leu Ile Gly Asn Glu Asn 
            820                 825                 830         


His Gly Leu Tyr Leu Ala Asp Gln Tyr Val Lys Gly Ile Ala Lys Ser 
        835                 840                 845             


Arg Lys Ser Gly Ser 
    850             


<210> 224
<211> 856
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 224
Ser Ser Gln Cys Val Asn Phe Thr Asn Arg Thr Gln Leu Pro Ser Ala 
1               5                   10                  15      


Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe 
            20                  25                  30          


Arg Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe 
        35                  40                  45              


Ser Asn Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly 
    50                  55                  60                  


Thr Lys Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr 
65                  70                  75                  80  


Phe Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly 
                85                  90                  95      


Thr Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala 
            100                 105                 110         


Thr Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Tyr Pro 
        115                 120                 125             


Phe Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser 
    130                 135                 140                 


Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val 
145                 150                 155                 160 


Ser Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys 
                165                 170                 175     


Asn Leu Ser Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile 
            180                 185                 190         


Tyr Ser Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly 
        195                 200                 205             


Phe Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile 
    210                 215                 220                 


Thr Arg Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro 
225                 230                 235                 240 


Gly Asp Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val 
                245                 250                 255     


Gly Tyr Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly 
            260                 265                 270         


Thr Ile Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr 
        275                 280                 285             


Lys Cys Thr Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr 
    290                 295                 300                 


Ser Asn Phe Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn 
305                 310                 315                 320 


Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe 
                325                 330                 335     


Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala 
            340                 345                 350         


Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys 
        355                 360                 365             


Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val 
    370                 375                 380                 


Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala 
385                 390                 395                 400 


Pro Gly Gln Thr Gly Thr Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp 
                405                 410                 415     


Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser 
            420                 425                 430         


Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser 
        435                 440                 445             


Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala 
    450                 455                 460                 


Gly Ser Thr Pro Cys Asn Gly Val Lys Gly Phe Asn Cys Tyr Phe Pro 
465                 470                 475                 480 


Leu Gln Ser Tyr Gly Phe Gln Pro Thr Tyr Gly Val Gly Tyr Gln Pro 
                485                 490                 495     


Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr 
            500                 505                 510         


Val Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val 
        515                 520                 525             


Asn Phe Asn Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser 
    530                 535                 540                 


Asn Lys Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp 
545                 550                 555                 560 


Thr Thr Asp Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile 
                565                 570                 575     


Thr Pro Cys Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn 
            580                 585                 590         


Thr Ser Asn Gln Val Ala Val Leu Tyr Gln Gly Val Asn Cys Thr Glu 
        595                 600                 605             


Val Pro Val Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val 
    610                 615                 620                 


Tyr Ser Thr Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile 
625                 630                 635                 640 


Gly Ala Glu Tyr Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly 
                645                 650                 655     


Ala Gly Ile Cys Ala Ser Tyr Gln Thr Gly Gly Ser Gln Ser Ile Ile 
            660                 665                 670         


Ala Tyr Thr Gly Ser Gly Gly Gly Gly Glu Ser Gln Val Arg Gln Gln 
        675                 680                 685             


Phe Ser Lys Asp Ile Glu Lys Leu Leu Asn Glu Gln Val Asn Lys Glu 
    690                 695                 700                 


Met Gln Ser Ser Asn Leu Tyr Met Ser Met Ser Ser Trp Cys Tyr Thr 
705                 710                 715                 720 


His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp His Ala Ala Glu 
                725                 730                 735     


Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe Leu Asn Glu Asn Asn 
            740                 745                 750         


Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro Glu His Lys Phe Glu 
        755                 760                 765             


Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu His Glu Gln His Ile 
    770                 775                 780                 


Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala Ile Lys Ser Lys Asp 
785                 790                 795                 800 


His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala Glu Gln His Glu 
                805                 810                 815     


Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys Ile Glu Leu Ile Gly 
            820                 825                 830         


Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr Val Lys Gly Ile 
        835                 840                 845             


Ala Lys Ser Arg Lys Ser Gly Ser 
    850                 855     


<210> 225
<211> 691
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 225
His His His His His His His His Gly Pro Leu Glu Val Leu Phe Gln 
1               5                   10                  15      


Gly Pro Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala 
            20                  25                  30          


Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn 
        35                  40                  45              


Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr 
    50                  55                  60                  


Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe 
65                  70                  75                  80  


Thr Asn Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg 
                85                  90                  95      


Gln Ile Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys 
            100                 105                 110         


Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn 
        115                 120                 125             


Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Arg Arg Leu Phe 
    130                 135                 140                 


Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile 
145                 150                 155                 160 


Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys 
                165                 170                 175     


Tyr Phe Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Tyr Gly Val Gly 
            180                 185                 190         


Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe Glu Asn Lys Ser Ala 
        195                 200                 205             


Pro Ala Thr Val Cys Gly Pro Gly Ser Gly Gly Ser Gly Ser Ser Gln 
    210                 215                 220                 


Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn 
225                 230                 235                 240 


Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser 
                245                 250                 255     


Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val 
            260                 265                 270         


Thr Trp Phe His Ala Ile Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
        275                 280                 285             


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
    290                 295                 300                 


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
305                 310                 315                 320 


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
                325                 330                 335     


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
            340                 345                 350         


His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr Ser 
        355                 360                 365             


Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu Met 
    370                 375                 380                 


Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe Val 
385                 390                 395                 400 


Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr Pro 
                405                 410                 415     


Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu Pro 
            420                 425                 430         


Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr Leu 
        435                 440                 445             


Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser Gly 
    450                 455                 460                 


Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro Arg 
465                 470                 475                 480 


Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala Val 
                485                 490                 495     


Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Gly Ser 
            500                 505                 510         


Gly Gly Gly Gly Glu Ser Gln Val Arg Gln Gln Phe Ser Lys Asp Ile 
        515                 520                 525             


Glu Lys Leu Leu Asn Glu Gln Val Asn Lys Glu Met Gln Ser Ser Asn 
    530                 535                 540                 


Leu Tyr Met Ser Met Ser Ser Trp Cys Tyr Thr His Ser Leu Asp Gly 
545                 550                 555                 560 


Ala Gly Leu Phe Leu Phe Asp His Ala Ala Glu Glu Tyr Glu His Ala 
                565                 570                 575     


Lys Lys Leu Ile Ile Phe Leu Asn Glu Asn Asn Val Pro Val Gln Leu 
            580                 585                 590         


Thr Ser Ile Ser Ala Pro Glu His Lys Phe Glu Gly Leu Thr Gln Ile 
        595                 600                 605             


Phe Gln Lys Ala Tyr Glu His Glu Gln His Ile Ser Glu Ser Ile Asn 
    610                 615                 620                 


Asn Ile Val Asp His Ala Ile Lys Ser Lys Asp His Ala Thr Phe Asn 
625                 630                 635                 640 


Phe Leu Gln Trp Tyr Val Ala Glu Gln His Glu Glu Glu Val Leu Phe 
                645                 650                 655     


Lys Asp Ile Leu Asp Lys Ile Glu Leu Ile Gly Asn Glu Asn His Gly 
            660                 665                 670         


Leu Tyr Leu Ala Asp Gln Tyr Val Lys Gly Ile Ala Lys Ser Arg Lys 
        675                 680                 685             


Ser Gly Ser 
    690     


<210> 226
<211> 691
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 226
His His His His His His His His Gly Pro Leu Glu Val Leu Phe Gln 
1               5                   10                  15      


Gly Pro Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala 
            20                  25                  30          


Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn 
        35                  40                  45              


Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr 
    50                  55                  60                  


Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe 
65                  70                  75                  80  


Thr Asn Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg 
                85                  90                  95      


Gln Ile Ala Pro Gly Gln Thr Gly Asn Ile Ala Asp Tyr Asn Tyr Lys 
            100                 105                 110         


Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn 
        115                 120                 125             


Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Arg Arg Leu Phe 
    130                 135                 140                 


Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile 
145                 150                 155                 160 


Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly Val Lys Gly Phe Asn Cys 
                165                 170                 175     


Tyr Phe Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Tyr Gly Val Gly 
            180                 185                 190         


Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe Glu Asn Lys Ser Ala 
        195                 200                 205             


Pro Ala Thr Val Cys Gly Pro Gly Ser Gly Gly Ser Gly Ser Ser Gln 
    210                 215                 220                 


Cys Val Asn Phe Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn 
225                 230                 235                 240 


Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser 
                245                 250                 255     


Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val 
            260                 265                 270         


Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg 
        275                 280                 285             


Phe Ala Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser 
    290                 295                 300                 


Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu 
305                 310                 315                 320 


Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val 
                325                 330                 335     


Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly 
            340                 345                 350         


Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg 
        355                 360                 365             


Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro 
    370                 375                 380                 


Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg 
385                 390                 395                 400 


Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys 
                405                 410                 415     


His Thr Pro Ile Asn Leu Val Arg Gly Leu Pro Gln Gly Phe Ser Ala 
            420                 425                 430         


Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe 
        435                 440                 445             


Gln Thr Leu His Ile Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser Gly 
    450                 455                 460                 


Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro Arg 
465                 470                 475                 480 


Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala Val 
                485                 490                 495     


Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Gly Ser 
            500                 505                 510         


Gly Gly Gly Gly Glu Ser Gln Val Arg Gln Gln Phe Ser Lys Asp Ile 
        515                 520                 525             


Glu Lys Leu Leu Asn Glu Gln Val Asn Lys Glu Met Gln Ser Ser Asn 
    530                 535                 540                 


Leu Tyr Met Ser Met Ser Ser Trp Cys Tyr Thr His Ser Leu Asp Gly 
545                 550                 555                 560 


Ala Gly Leu Phe Leu Phe Asp His Ala Ala Glu Glu Tyr Glu His Ala 
                565                 570                 575     


Lys Lys Leu Ile Ile Phe Leu Asn Glu Asn Asn Val Pro Val Gln Leu 
            580                 585                 590         


Thr Ser Ile Ser Ala Pro Glu His Lys Phe Glu Gly Leu Thr Gln Ile 
        595                 600                 605             


Phe Gln Lys Ala Tyr Glu His Glu Gln His Ile Ser Glu Ser Ile Asn 
    610                 615                 620                 


Asn Ile Val Asp His Ala Ile Lys Ser Lys Asp His Ala Thr Phe Asn 
625                 630                 635                 640 


Phe Leu Gln Trp Tyr Val Ala Glu Gln His Glu Glu Glu Val Leu Phe 
                645                 650                 655     


Lys Asp Ile Leu Asp Lys Ile Glu Leu Ile Gly Asn Glu Asn His Gly 
            660                 665                 670         


Leu Tyr Leu Ala Asp Gln Tyr Val Lys Gly Ile Ala Lys Ser Arg Lys 
        675                 680                 685             


Ser Gly Ser 
    690     


<210> 227
<211> 691
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 227
His His His His His His His His Gly Pro Leu Glu Val Leu Phe Gln 
1               5                   10                  15      


Gly Pro Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala 
            20                  25                  30          


Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn 
        35                  40                  45              


Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr 
    50                  55                  60                  


Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe 
65                  70                  75                  80  


Thr Asn Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg 
                85                  90                  95      


Gln Ile Ala Pro Gly Gln Thr Gly Asn Ile Ala Asp Tyr Asn Tyr Lys 
            100                 105                 110         


Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn 
        115                 120                 125             


Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Arg Arg Leu Phe 
    130                 135                 140                 


Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile 
145                 150                 155                 160 


Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly Val Lys Gly Phe Asn Cys 
                165                 170                 175     


Tyr Phe Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Tyr Gly Val Gly 
            180                 185                 190         


Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe Glu Asn Lys Ser Ala 
        195                 200                 205             


Pro Ala Thr Val Cys Gly Pro Gly Ser Gly Gly Ser Gly Ser Ser Gln 
    210                 215                 220                 


Cys Val Asn Phe Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn 
225                 230                 235                 240 


Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser 
                245                 250                 255     


Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val 
            260                 265                 270         


Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg 
        275                 280                 285             


Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser 
    290                 295                 300                 


Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu 
305                 310                 315                 320 


Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val 
                325                 330                 335     


Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly 
            340                 345                 350         


Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg 
        355                 360                 365             


Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro 
    370                 375                 380                 


Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg 
385                 390                 395                 400 


Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys 
                405                 410                 415     


His Thr Pro Ile Asn Leu Val Arg Gly Leu Pro Gln Gly Phe Ser Ala 
            420                 425                 430         


Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe 
        435                 440                 445             


Gln Thr Leu His Ile Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser Gly 
    450                 455                 460                 


Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro Arg 
465                 470                 475                 480 


Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala Val 
                485                 490                 495     


Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Gly Ser 
            500                 505                 510         


Gly Gly Gly Gly Glu Ser Gln Val Arg Gln Gln Phe Ser Lys Asp Ile 
        515                 520                 525             


Glu Lys Leu Leu Asn Glu Gln Val Asn Lys Glu Met Gln Ser Ser Asn 
    530                 535                 540                 


Leu Tyr Met Ser Met Ser Ser Trp Cys Tyr Thr His Ser Leu Asp Gly 
545                 550                 555                 560 


Ala Gly Leu Phe Leu Phe Asp His Ala Ala Glu Glu Tyr Glu His Ala 
                565                 570                 575     


Lys Lys Leu Ile Ile Phe Leu Asn Glu Asn Asn Val Pro Val Gln Leu 
            580                 585                 590         


Thr Ser Ile Ser Ala Pro Glu His Lys Phe Glu Gly Leu Thr Gln Ile 
        595                 600                 605             


Phe Gln Lys Ala Tyr Glu His Glu Gln His Ile Ser Glu Ser Ile Asn 
    610                 615                 620                 


Asn Ile Val Asp His Ala Ile Lys Ser Lys Asp His Ala Thr Phe Asn 
625                 630                 635                 640 


Phe Leu Gln Trp Tyr Val Ala Glu Gln His Glu Glu Glu Val Leu Phe 
                645                 650                 655     


Lys Asp Ile Leu Asp Lys Ile Glu Leu Ile Gly Asn Glu Asn His Gly 
            660                 665                 670         


Leu Tyr Leu Ala Asp Gln Tyr Val Lys Gly Ile Ala Lys Ser Arg Lys 
        675                 680                 685             


Ser Gly Ser 
    690     


<210> 228
<211> 691
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 228
His His His His His His His His Gly Pro Leu Glu Val Leu Phe Gln 
1               5                   10                  15      


Gly Pro Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala 
            20                  25                  30          


Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn 
        35                  40                  45              


Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr 
    50                  55                  60                  


Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe 
65                  70                  75                  80  


Thr Asn Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg 
                85                  90                  95      


Gln Ile Ala Pro Gly Gln Thr Gly Asn Ile Ala Asp Tyr Asn Tyr Lys 
            100                 105                 110         


Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn 
        115                 120                 125             


Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Arg Arg Leu Phe 
    130                 135                 140                 


Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile 
145                 150                 155                 160 


Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly Val Lys Gly Phe Asn Cys 
                165                 170                 175     


Tyr Phe Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Tyr Gly Val Gly 
            180                 185                 190         


Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe Glu Asn Lys Ser Ala 
        195                 200                 205             


Pro Ala Thr Val Cys Gly Pro Gly Ser Gly Gly Ser Gly Ser Ser Gln 
    210                 215                 220                 


Cys Val Asn Phe Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn 
225                 230                 235                 240 


Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser 
                245                 250                 255     


Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val 
            260                 265                 270         


Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg 
        275                 280                 285             


Phe Ala Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser 
    290                 295                 300                 


Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu 
305                 310                 315                 320 


Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val 
                325                 330                 335     


Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly 
            340                 345                 350         


Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg 
        355                 360                 365             


Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro 
    370                 375                 380                 


Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg 
385                 390                 395                 400 


Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys 
                405                 410                 415     


His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala 
            420                 425                 430         


Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe 
        435                 440                 445             


Gln Thr Leu His Ile Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser Gly 
    450                 455                 460                 


Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro Arg 
465                 470                 475                 480 


Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala Val 
                485                 490                 495     


Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Gly Ser 
            500                 505                 510         


Gly Gly Gly Gly Glu Ser Gln Val Arg Gln Gln Phe Ser Lys Asp Ile 
        515                 520                 525             


Glu Lys Leu Leu Asn Glu Gln Val Asn Lys Glu Met Gln Ser Ser Asn 
    530                 535                 540                 


Leu Tyr Met Ser Met Ser Ser Trp Cys Tyr Thr His Ser Leu Asp Gly 
545                 550                 555                 560 


Ala Gly Leu Phe Leu Phe Asp His Ala Ala Glu Glu Tyr Glu His Ala 
                565                 570                 575     


Lys Lys Leu Ile Ile Phe Leu Asn Glu Asn Asn Val Pro Val Gln Leu 
            580                 585                 590         


Thr Ser Ile Ser Ala Pro Glu His Lys Phe Glu Gly Leu Thr Gln Ile 
        595                 600                 605             


Phe Gln Lys Ala Tyr Glu His Glu Gln His Ile Ser Glu Ser Ile Asn 
    610                 615                 620                 


Asn Ile Val Asp His Ala Ile Lys Ser Lys Asp His Ala Thr Phe Asn 
625                 630                 635                 640 


Phe Leu Gln Trp Tyr Val Ala Glu Gln His Glu Glu Glu Val Leu Phe 
                645                 650                 655     


Lys Asp Ile Leu Asp Lys Ile Glu Leu Ile Gly Asn Glu Asn His Gly 
            660                 665                 670         


Leu Tyr Leu Ala Asp Gln Tyr Val Lys Gly Ile Ala Lys Ser Arg Lys 
        675                 680                 685             


Ser Gly Ser 
    690     


<210> 229
<211> 694
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 229
His His His His His His His His Gly Pro Leu Glu Val Leu Phe Gln 
1               5                   10                  15      


Gly Pro Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala 
            20                  25                  30          


Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn 
        35                  40                  45              


Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr 
    50                  55                  60                  


Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe 
65                  70                  75                  80  


Thr Asn Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg 
                85                  90                  95      


Gln Ile Ala Pro Gly Gln Thr Gly Thr Ile Ala Asp Tyr Asn Tyr Lys 
            100                 105                 110         


Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn 
        115                 120                 125             


Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Arg Arg Leu Phe 
    130                 135                 140                 


Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile 
145                 150                 155                 160 


Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly Val Lys Gly Phe Asn Cys 
                165                 170                 175     


Tyr Phe Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Tyr Gly Val Gly 
            180                 185                 190         


Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe Glu Asn Lys Ser Ala 
        195                 200                 205             


Pro Ala Thr Val Cys Gly Pro Gly Ser Gly Gly Ser Gly Ser Ser Gln 
    210                 215                 220                 


Cys Val Asn Phe Thr Asn Arg Thr Gln Leu Pro Ser Ala Tyr Thr Asn 
225                 230                 235                 240 


Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser 
                245                 250                 255     


Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val 
            260                 265                 270         


Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg 
        275                 280                 285             


Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser 
    290                 295                 300                 


Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu 
305                 310                 315                 320 


Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val 
                325                 330                 335     


Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Tyr Pro Phe Leu Gly 
            340                 345                 350         


Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg 
        355                 360                 365             


Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro 
    370                 375                 380                 


Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Ser 
385                 390                 395                 400 


Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys 
                405                 410                 415     


His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala 
            420                 425                 430         


Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe 
        435                 440                 445             


Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser 
    450                 455                 460                 


Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu 
465                 470                 475                 480 


Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr 
                485                 490                 495     


Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr 
            500                 505                 510         


Leu Gly Ser Gly Gly Gly Gly Glu Ser Gln Val Arg Gln Gln Phe Ser 
        515                 520                 525             


Lys Asp Ile Glu Lys Leu Leu Asn Glu Gln Val Asn Lys Glu Met Gln 
    530                 535                 540                 


Ser Ser Asn Leu Tyr Met Ser Met Ser Ser Trp Cys Tyr Thr His Ser 
545                 550                 555                 560 


Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp His Ala Ala Glu Glu Tyr 
                565                 570                 575     


Glu His Ala Lys Lys Leu Ile Ile Phe Leu Asn Glu Asn Asn Val Pro 
            580                 585                 590         


Val Gln Leu Thr Ser Ile Ser Ala Pro Glu His Lys Phe Glu Gly Leu 
        595                 600                 605             


Thr Gln Ile Phe Gln Lys Ala Tyr Glu His Glu Gln His Ile Ser Glu 
    610                 615                 620                 


Ser Ile Asn Asn Ile Val Asp His Ala Ile Lys Ser Lys Asp His Ala 
625                 630                 635                 640 


Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala Glu Gln His Glu Glu Glu 
                645                 650                 655     


Val Leu Phe Lys Asp Ile Leu Asp Lys Ile Glu Leu Ile Gly Asn Glu 
            660                 665                 670         


Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr Val Lys Gly Ile Ala Lys 
        675                 680                 685             


Ser Arg Lys Ser Gly Ser 
    690                 


<210> 230
<211> 1315
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 230
Ser Ser Gln Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala 
1               5                   10                  15      


Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe 
            20                  25                  30          


Arg Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe 
        35                  40                  45              


Ser Asn Val Thr Trp Phe His Ala Ile Ser Gly Thr Asn Gly Thr Lys 
    50                  55                  60                  


Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala 
65                  70                  75                  80  


Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr 
                85                  90                  95      


Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn 
            100                 105                 110         


Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu 
        115                 120                 125             


Gly Val Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg 
    130                 135                 140                 


Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro 
145                 150                 155                 160 


Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg 
                165                 170                 175     


Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys 
            180                 185                 190         


His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala 
        195                 200                 205             


Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe 
    210                 215                 220                 


Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser 
225                 230                 235                 240 


Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu 
                245                 250                 255     


Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr 
            260                 265                 270         


Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr 
        275                 280                 285             


Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe 
    290                 295                 300                 


Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn 
305                 310                 315                 320 


Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val 
                325                 330                 335     


Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser 
            340                 345                 350         


Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val 
        355                 360                 365             


Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp 
    370                 375                 380                 


Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln 
385                 390                 395                 400 


Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr 
                405                 410                 415     


Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly 
            420                 425                 430         


Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys 
        435                 440                 445             


Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr 
    450                 455                 460                 


Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser 
465                 470                 475                 480 


Tyr Gly Phe Gln Pro Thr Tyr Gly Val Gly Tyr Gln Pro Tyr Arg Val 
                485                 490                 495     


Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly 
            500                 505                 510         


Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn 
        515                 520                 525             


Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys 
    530                 535                 540                 


Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Asp Asp Thr Thr Asp 
545                 550                 555                 560 


Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys 
                565                 570                 575     


Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn 
            580                 585                 590         


Gln Val Ala Val Leu Tyr Gln Gly Val Asn Cys Thr Glu Val Pro Val 
        595                 600                 605             


Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr 
    610                 615                 620                 


Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu 
625                 630                 635                 640 


His Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile 
                645                 650                 655     


Cys Ala Ser Tyr Gln Thr Gln Thr Asn Ser His Gly Ser Ala Ser Ser 
            660                 665                 670         


Val Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu 
        675                 680                 685             


Asn Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Ile Asn Phe 
    690                 695                 700                 


Thr Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr 
705                 710                 715                 720 


Ser Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser 
                725                 730                 735     


Asn Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala 
            740                 745                 750         


Leu Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe 
        755                 760                 765             


Ala Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly 
    770                 775                 780                 


Gly Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys 
785                 790                 795                 800 


Arg Ser Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp 
                805                 810                 815     


Ala Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala 
            820                 825                 830         


Arg Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro 
        835                 840                 845             


Pro Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu 
    850                 855                 860                 


Ala Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu 
865                 870                 875                 880 


Gln Ile Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly 
                885                 890                 895     


Val Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln 
            900                 905                 910         


Phe Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala 
        915                 920                 925             


Ser Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala 
    930                 935                 940                 


Leu Asn Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser 
945                 950                 955                 960 


Ser Val Leu Asn Asp Ile Leu Ala Arg Leu Asp Pro Pro Glu Ala Glu 
                965                 970                 975     


Val Gln Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser Leu Gln Thr 
            980                 985                 990         


Tyr Val Thr Gln Gln Leu Ile Arg  Ala Ala Glu Ile Arg  Ala Ser Ala 
        995                 1000                 1005             


Asn Leu  Ala Ala Thr Lys Met  Ser Glu Cys Val Leu  Gly Gln Ser 
    1010                 1015                 1020             


Lys Arg  Val Asp Phe Cys Gly  Lys Gly Tyr His Leu  Met Ser Phe 
    1025                 1030                 1035             


Pro Gln  Ser Ala Pro His Gly  Val Val Phe Leu His  Val Thr Tyr 
    1040                 1045                 1050             


Val Pro  Ala Gln Glu Lys Asn  Phe Thr Thr Ala Pro  Ala Ile Cys 
    1055                 1060                 1065             


His Asp  Gly Lys Ala His Phe  Pro Arg Glu Gly Val  Phe Val Ser 
    1070                 1075                 1080             


Asn Gly  Thr His Trp Phe Val  Thr Gln Arg Asn Phe  Tyr Glu Pro 
    1085                 1090                 1095             


Gln Ile  Ile Thr Thr His Asn  Thr Phe Val Ser Gly  Asn Cys Asp 
    1100                 1105                 1110             


Val Val  Ile Gly Ile Val Asn  Asn Thr Val Tyr Asp  Pro Leu Gln 
    1115                 1120                 1125             


Ser Glu  Leu Asp Ser Ile Lys  Glu Glu Leu Asp Lys  Ile His Lys 
    1130                 1135                 1140             


Asn Gly  Ser Gly Gly Ser Gly  Asp Ile Ile Lys Leu  Leu Asn Glu 
    1145                 1150                 1155             


Gln Val  Asn Lys Glu Met Gln  Ser Ser Asn Leu Tyr  Met Ser Met 
    1160                 1165                 1170             


Ser Ser  Trp Cys Tyr Thr His  Ser Leu Asp Gly Ala  Gly Leu Phe 
    1175                 1180                 1185             


Leu Phe  Asp His Ala Ala Glu  Glu Tyr Glu His Ala  Lys Lys Leu 
    1190                 1195                 1200             


Ile Ile  Phe Leu Asn Glu Asn  Asn Val Pro Val Gln  Leu Thr Ser 
    1205                 1210                 1215             


Ile Ser  Ala Pro Glu His Lys  Phe Glu Gly Leu Thr  Gln Ile Phe 
    1220                 1225                 1230             


Gln Lys  Ala Tyr Glu His Glu  Gln His Ile Ser Glu  Ser Ile Asn 
    1235                 1240                 1245             


Asn Ile  Val Asp His Ala Ile  Lys Ser Lys Asp His  Ala Thr Phe 
    1250                 1255                 1260             


Asn Phe  Leu Gln Trp Tyr Val  Ala Glu Gln His Glu  Glu Glu Val 
    1265                 1270                 1275             


Leu Phe  Lys Asp Ile Leu Asp  Lys Ile Glu Leu Ile  Gly Asn Glu 
    1280                 1285                 1290             


Asn His  Gly Leu Tyr Leu Ala  Asp Gln Tyr Val Lys  Gly Ile Ala 
    1295                 1300                 1305             


Lys Ser  Arg Lys Ser Gly Ser  
    1310                 1315 


<210> 231
<211> 1315
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 231
Ser Ser Gln Cys Val Asn Phe Thr Thr Arg Thr Gln Leu Pro Pro Ala 
1               5                   10                  15      


Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe 
            20                  25                  30          


Arg Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe 
        35                  40                  45              


Ser Asn Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly 
    50                  55                  60                  


Thr Lys Arg Phe Ala Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr 
65                  70                  75                  80  


Phe Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly 
                85                  90                  95      


Thr Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala 
            100                 105                 110         


Thr Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro 
        115                 120                 125             


Phe Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser 
    130                 135                 140                 


Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val 
145                 150                 155                 160 


Ser Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys 
                165                 170                 175     


Asn Leu Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile 
            180                 185                 190         


Tyr Ser Lys His Thr Pro Ile Asn Leu Val Arg Gly Leu Pro Gln Gly 
        195                 200                 205             


Phe Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile 
    210                 215                 220                 


Thr Arg Phe Gln Thr Leu His Ile Ser Tyr Leu Thr Pro Gly Asp Ser 
225                 230                 235                 240 


Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu 
                245                 250                 255     


Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr 
            260                 265                 270         


Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr 
        275                 280                 285             


Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe 
    290                 295                 300                 


Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn 
305                 310                 315                 320 


Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val 
                325                 330                 335     


Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser 
            340                 345                 350         


Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val 
        355                 360                 365             


Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp 
    370                 375                 380                 


Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln 
385                 390                 395                 400 


Thr Gly Asn Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr 
                405                 410                 415     


Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly 
            420                 425                 430         


Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys 
        435                 440                 445             


Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr 
    450                 455                 460                 


Pro Cys Asn Gly Val Lys Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser 
465                 470                 475                 480 


Tyr Gly Phe Gln Pro Thr Tyr Gly Val Gly Tyr Gln Pro Tyr Arg Val 
                485                 490                 495     


Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly 
            500                 505                 510         


Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn 
        515                 520                 525             


Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys 
    530                 535                 540                 


Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp 
545                 550                 555                 560 


Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys 
                565                 570                 575     


Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn 
            580                 585                 590         


Gln Val Ala Val Leu Tyr Gln Gly Val Asn Cys Thr Glu Val Pro Val 
        595                 600                 605             


Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr 
    610                 615                 620                 


Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu 
625                 630                 635                 640 


His Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile 
                645                 650                 655     


Cys Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro Gly Ser Ala Ser Ser 
            660                 665                 670         


Val Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Val Glu 
        675                 680                 685             


Asn Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe 
    690                 695                 700                 


Thr Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr 
705                 710                 715                 720 


Ser Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser 
                725                 730                 735     


Asn Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala 
            740                 745                 750         


Leu Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe 
        755                 760                 765             


Ala Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly 
    770                 775                 780                 


Gly Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys 
785                 790                 795                 800 


Arg Ser Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp 
                805                 810                 815     


Ala Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala 
            820                 825                 830         


Arg Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro 
        835                 840                 845             


Pro Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu 
    850                 855                 860                 


Ala Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu 
865                 870                 875                 880 


Gln Ile Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly 
                885                 890                 895     


Val Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln 
            900                 905                 910         


Phe Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala 
        915                 920                 925             


Ser Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala 
    930                 935                 940                 


Leu Asn Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser 
945                 950                 955                 960 


Ser Val Leu Asn Asp Ile Leu Ser Arg Leu Asp Pro Pro Glu Ala Glu 
                965                 970                 975     


Val Gln Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser Leu Gln Thr 
            980                 985                 990         


Tyr Val Thr Gln Gln Leu Ile Arg  Ala Ala Glu Ile Arg  Ala Ser Ala 
        995                 1000                 1005             


Asn Leu  Ala Ala Thr Lys Met  Ser Glu Cys Val Leu  Gly Gln Ser 
    1010                 1015                 1020             


Lys Arg  Val Asp Phe Cys Gly  Lys Gly Tyr His Leu  Met Ser Phe 
    1025                 1030                 1035             


Pro Gln  Ser Ala Pro His Gly  Val Val Phe Leu His  Val Thr Tyr 
    1040                 1045                 1050             


Val Pro  Ala Gln Glu Lys Asn  Phe Thr Thr Ala Pro  Ala Ile Cys 
    1055                 1060                 1065             


His Asp  Gly Lys Ala His Phe  Pro Arg Glu Gly Val  Phe Val Ser 
    1070                 1075                 1080             


Asn Gly  Thr His Trp Phe Val  Thr Gln Arg Asn Phe  Tyr Glu Pro 
    1085                 1090                 1095             


Gln Ile  Ile Thr Thr Asp Asn  Thr Phe Val Ser Gly  Asn Cys Asp 
    1100                 1105                 1110             


Val Val  Ile Gly Ile Val Asn  Asn Thr Val Tyr Asp  Pro Leu Gln 
    1115                 1120                 1125             


Ser Glu  Leu Asp Ser Ile Lys  Glu Glu Leu Asp Lys  Ile His Lys 
    1130                 1135                 1140             


Asn Gly  Ser Gly Gly Ser Gly  Asp Ile Ile Lys Leu  Leu Asn Glu 
    1145                 1150                 1155             


Gln Val  Asn Lys Glu Met Gln  Ser Ser Asn Leu Tyr  Met Ser Met 
    1160                 1165                 1170             


Ser Ser  Trp Cys Tyr Thr His  Ser Leu Asp Gly Ala  Gly Leu Phe 
    1175                 1180                 1185             


Leu Phe  Asp His Ala Ala Glu  Glu Tyr Glu His Ala  Lys Lys Leu 
    1190                 1195                 1200             


Ile Ile  Phe Leu Asn Glu Asn  Asn Val Pro Val Gln  Leu Thr Ser 
    1205                 1210                 1215             


Ile Ser  Ala Pro Glu His Lys  Phe Glu Gly Leu Thr  Gln Ile Phe 
    1220                 1225                 1230             


Gln Lys  Ala Tyr Glu His Glu  Gln His Ile Ser Glu  Ser Ile Asn 
    1235                 1240                 1245             


Asn Ile  Val Asp His Ala Ile  Lys Ser Lys Asp His  Ala Thr Phe 
    1250                 1255                 1260             


Asn Phe  Leu Gln Trp Tyr Val  Ala Glu Gln His Glu  Glu Glu Val 
    1265                 1270                 1275             


Leu Phe  Lys Asp Ile Leu Asp  Lys Ile Glu Leu Ile  Gly Asn Glu 
    1280                 1285                 1290             


Asn His  Gly Leu Tyr Leu Ala  Asp Gln Tyr Val Lys  Gly Ile Ala 
    1295                 1300                 1305             


Lys Ser  Arg Lys Ser Gly Ser  
    1310                 1315 


<210> 232
<211> 1315
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 232
Ser Ser Gln Cys Val Asn Phe Thr Thr Arg Thr Gln Leu Pro Pro Ala 
1               5                   10                  15      


Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe 
            20                  25                  30          


Arg Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe 
        35                  40                  45              


Ser Asn Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly 
    50                  55                  60                  


Thr Lys Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr 
65                  70                  75                  80  


Phe Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly 
                85                  90                  95      


Thr Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala 
            100                 105                 110         


Thr Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro 
        115                 120                 125             


Phe Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser 
    130                 135                 140                 


Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val 
145                 150                 155                 160 


Ser Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys 
                165                 170                 175     


Asn Leu Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile 
            180                 185                 190         


Tyr Ser Lys His Thr Pro Ile Asn Leu Val Arg Gly Leu Pro Gln Gly 
        195                 200                 205             


Phe Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile 
    210                 215                 220                 


Thr Arg Phe Gln Thr Leu His Ile Ser Tyr Leu Thr Pro Gly Asp Ser 
225                 230                 235                 240 


Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu 
                245                 250                 255     


Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr 
            260                 265                 270         


Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr 
        275                 280                 285             


Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe 
    290                 295                 300                 


Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn 
305                 310                 315                 320 


Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val 
                325                 330                 335     


Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser 
            340                 345                 350         


Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val 
        355                 360                 365             


Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp 
    370                 375                 380                 


Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln 
385                 390                 395                 400 


Thr Gly Asn Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr 
                405                 410                 415     


Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly 
            420                 425                 430         


Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys 
        435                 440                 445             


Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr 
    450                 455                 460                 


Pro Cys Asn Gly Val Lys Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser 
465                 470                 475                 480 


Tyr Gly Phe Gln Pro Thr Tyr Gly Val Gly Tyr Gln Pro Tyr Arg Val 
                485                 490                 495     


Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly 
            500                 505                 510         


Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn 
        515                 520                 525             


Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys 
    530                 535                 540                 


Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp 
545                 550                 555                 560 


Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys 
                565                 570                 575     


Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn 
            580                 585                 590         


Gln Val Ala Val Leu Tyr Gln Gly Val Asn Cys Thr Glu Val Pro Val 
        595                 600                 605             


Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr 
    610                 615                 620                 


Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu 
625                 630                 635                 640 


His Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile 
                645                 650                 655     


Cys Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro Gly Ser Ala Ser Ser 
            660                 665                 670         


Val Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Val Glu 
        675                 680                 685             


Asn Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe 
    690                 695                 700                 


Thr Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr 
705                 710                 715                 720 


Ser Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser 
                725                 730                 735     


Asn Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala 
            740                 745                 750         


Leu Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe 
        755                 760                 765             


Ala Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly 
    770                 775                 780                 


Gly Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys 
785                 790                 795                 800 


Arg Ser Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp 
                805                 810                 815     


Ala Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala 
            820                 825                 830         


Arg Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro 
        835                 840                 845             


Pro Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu 
    850                 855                 860                 


Ala Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu 
865                 870                 875                 880 


Gln Ile Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly 
                885                 890                 895     


Val Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln 
            900                 905                 910         


Phe Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala 
        915                 920                 925             


Ser Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala 
    930                 935                 940                 


Leu Asn Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser 
945                 950                 955                 960 


Ser Val Leu Asn Asp Ile Leu Ser Arg Leu Asp Pro Pro Glu Ala Glu 
                965                 970                 975     


Val Gln Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser Leu Gln Thr 
            980                 985                 990         


Tyr Val Thr Gln Gln Leu Ile Arg  Ala Ala Glu Ile Arg  Ala Ser Ala 
        995                 1000                 1005             


Asn Leu  Ala Ala Thr Lys Met  Ser Glu Cys Val Leu  Gly Gln Ser 
    1010                 1015                 1020             


Lys Arg  Val Asp Phe Cys Gly  Lys Gly Tyr His Leu  Met Ser Phe 
    1025                 1030                 1035             


Pro Gln  Ser Ala Pro His Gly  Val Val Phe Leu His  Val Thr Tyr 
    1040                 1045                 1050             


Val Pro  Ala Gln Glu Lys Asn  Phe Thr Thr Ala Pro  Ala Ile Cys 
    1055                 1060                 1065             


His Asp  Gly Lys Ala His Phe  Pro Arg Glu Gly Val  Phe Val Ser 
    1070                 1075                 1080             


Asn Gly  Thr His Trp Phe Val  Thr Gln Arg Asn Phe  Tyr Glu Pro 
    1085                 1090                 1095             


Gln Ile  Ile Thr Thr Asp Asn  Thr Phe Val Ser Gly  Asn Cys Asp 
    1100                 1105                 1110             


Val Val  Ile Gly Ile Val Asn  Asn Thr Val Tyr Asp  Pro Leu Gln 
    1115                 1120                 1125             


Ser Glu  Leu Asp Ser Ile Lys  Glu Glu Leu Asp Lys  Ile His Lys 
    1130                 1135                 1140             


Asn Gly  Ser Gly Gly Ser Gly  Asp Ile Ile Lys Leu  Leu Asn Glu 
    1145                 1150                 1155             


Gln Val  Asn Lys Glu Met Gln  Ser Ser Asn Leu Tyr  Met Ser Met 
    1160                 1165                 1170             


Ser Ser  Trp Cys Tyr Thr His  Ser Leu Asp Gly Ala  Gly Leu Phe 
    1175                 1180                 1185             


Leu Phe  Asp His Ala Ala Glu  Glu Tyr Glu His Ala  Lys Lys Leu 
    1190                 1195                 1200             


Ile Ile  Phe Leu Asn Glu Asn  Asn Val Pro Val Gln  Leu Thr Ser 
    1205                 1210                 1215             


Ile Ser  Ala Pro Glu His Lys  Phe Glu Gly Leu Thr  Gln Ile Phe 
    1220                 1225                 1230             


Gln Lys  Ala Tyr Glu His Glu  Gln His Ile Ser Glu  Ser Ile Asn 
    1235                 1240                 1245             


Asn Ile  Val Asp His Ala Ile  Lys Ser Lys Asp His  Ala Thr Phe 
    1250                 1255                 1260             


Asn Phe  Leu Gln Trp Tyr Val  Ala Glu Gln His Glu  Glu Glu Val 
    1265                 1270                 1275             


Leu Phe  Lys Asp Ile Leu Asp  Lys Ile Glu Leu Ile  Gly Asn Glu 
    1280                 1285                 1290             


Asn His  Gly Leu Tyr Leu Ala  Asp Gln Tyr Val Lys  Gly Ile Ala 
    1295                 1300                 1305             


Lys Ser  Arg Lys Ser Gly Ser  
    1310                 1315 


<210> 233
<211> 1315
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 233
Ser Ser Gln Cys Val Asn Phe Thr Thr Arg Thr Gln Leu Pro Pro Ala 
1               5                   10                  15      


Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe 
            20                  25                  30          


Arg Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe 
        35                  40                  45              


Ser Asn Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly 
    50                  55                  60                  


Thr Lys Arg Phe Ala Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr 
65                  70                  75                  80  


Phe Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly 
                85                  90                  95      


Thr Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala 
            100                 105                 110         


Thr Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro 
        115                 120                 125             


Phe Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser 
    130                 135                 140                 


Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val 
145                 150                 155                 160 


Ser Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys 
                165                 170                 175     


Asn Leu Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile 
            180                 185                 190         


Tyr Ser Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly 
        195                 200                 205             


Phe Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile 
    210                 215                 220                 


Thr Arg Phe Gln Thr Leu His Ile Ser Tyr Leu Thr Pro Gly Asp Ser 
225                 230                 235                 240 


Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu 
                245                 250                 255     


Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr 
            260                 265                 270         


Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr 
        275                 280                 285             


Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe 
    290                 295                 300                 


Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn 
305                 310                 315                 320 


Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val 
                325                 330                 335     


Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser 
            340                 345                 350         


Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val 
        355                 360                 365             


Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp 
    370                 375                 380                 


Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln 
385                 390                 395                 400 


Thr Gly Asn Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr 
                405                 410                 415     


Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly 
            420                 425                 430         


Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys 
        435                 440                 445             


Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr 
    450                 455                 460                 


Pro Cys Asn Gly Val Lys Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser 
465                 470                 475                 480 


Tyr Gly Phe Gln Pro Thr Tyr Gly Val Gly Tyr Gln Pro Tyr Arg Val 
                485                 490                 495     


Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly 
            500                 505                 510         


Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn 
        515                 520                 525             


Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys 
    530                 535                 540                 


Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp 
545                 550                 555                 560 


Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys 
                565                 570                 575     


Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn 
            580                 585                 590         


Gln Val Ala Val Leu Tyr Gln Gly Val Asn Cys Thr Glu Val Pro Val 
        595                 600                 605             


Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr 
    610                 615                 620                 


Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu 
625                 630                 635                 640 


His Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile 
                645                 650                 655     


Cys Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro Gly Ser Ala Ser Ser 
            660                 665                 670         


Val Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Val Glu 
        675                 680                 685             


Asn Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe 
    690                 695                 700                 


Thr Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr 
705                 710                 715                 720 


Ser Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser 
                725                 730                 735     


Asn Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala 
            740                 745                 750         


Leu Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe 
        755                 760                 765             


Ala Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly 
    770                 775                 780                 


Gly Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys 
785                 790                 795                 800 


Arg Ser Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp 
                805                 810                 815     


Ala Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala 
            820                 825                 830         


Arg Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro 
        835                 840                 845             


Pro Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu 
    850                 855                 860                 


Ala Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu 
865                 870                 875                 880 


Gln Ile Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly 
                885                 890                 895     


Val Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln 
            900                 905                 910         


Phe Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala 
        915                 920                 925             


Ser Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala 
    930                 935                 940                 


Leu Asn Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser 
945                 950                 955                 960 


Ser Val Leu Asn Asp Ile Leu Ser Arg Leu Asp Pro Pro Glu Ala Glu 
                965                 970                 975     


Val Gln Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser Leu Gln Thr 
            980                 985                 990         


Tyr Val Thr Gln Gln Leu Ile Arg  Ala Ala Glu Ile Arg  Ala Ser Ala 
        995                 1000                 1005             


Asn Leu  Ala Ala Thr Lys Met  Ser Glu Cys Val Leu  Gly Gln Ser 
    1010                 1015                 1020             


Lys Arg  Val Asp Phe Cys Gly  Lys Gly Tyr His Leu  Met Ser Phe 
    1025                 1030                 1035             


Pro Gln  Ser Ala Pro His Gly  Val Val Phe Leu His  Val Thr Tyr 
    1040                 1045                 1050             


Val Pro  Ala Gln Glu Lys Asn  Phe Thr Thr Ala Pro  Ala Ile Cys 
    1055                 1060                 1065             


His Asp  Gly Lys Ala His Phe  Pro Arg Glu Gly Val  Phe Val Ser 
    1070                 1075                 1080             


Asn Gly  Thr His Trp Phe Val  Thr Gln Arg Asn Phe  Tyr Glu Pro 
    1085                 1090                 1095             


Gln Ile  Ile Thr Thr Asp Asn  Thr Phe Val Ser Gly  Asn Cys Asp 
    1100                 1105                 1110             


Val Val  Ile Gly Ile Val Asn  Asn Thr Val Tyr Asp  Pro Leu Gln 
    1115                 1120                 1125             


Ser Glu  Leu Asp Ser Ile Lys  Glu Glu Leu Asp Lys  Ile His Lys 
    1130                 1135                 1140             


Asn Gly  Ser Gly Gly Ser Gly  Asp Ile Ile Lys Leu  Leu Asn Glu 
    1145                 1150                 1155             


Gln Val  Asn Lys Glu Met Gln  Ser Ser Asn Leu Tyr  Met Ser Met 
    1160                 1165                 1170             


Ser Ser  Trp Cys Tyr Thr His  Ser Leu Asp Gly Ala  Gly Leu Phe 
    1175                 1180                 1185             


Leu Phe  Asp His Ala Ala Glu  Glu Tyr Glu His Ala  Lys Lys Leu 
    1190                 1195                 1200             


Ile Ile  Phe Leu Asn Glu Asn  Asn Val Pro Val Gln  Leu Thr Ser 
    1205                 1210                 1215             


Ile Ser  Ala Pro Glu His Lys  Phe Glu Gly Leu Thr  Gln Ile Phe 
    1220                 1225                 1230             


Gln Lys  Ala Tyr Glu His Glu  Gln His Ile Ser Glu  Ser Ile Asn 
    1235                 1240                 1245             


Asn Ile  Val Asp His Ala Ile  Lys Ser Lys Asp His  Ala Thr Phe 
    1250                 1255                 1260             


Asn Phe  Leu Gln Trp Tyr Val  Ala Glu Gln His Glu  Glu Glu Val 
    1265                 1270                 1275             


Leu Phe  Lys Asp Ile Leu Asp  Lys Ile Glu Leu Ile  Gly Asn Glu 
    1280                 1285                 1290             


Asn His  Gly Leu Tyr Leu Ala  Asp Gln Tyr Val Lys  Gly Ile Ala 
    1295                 1300                 1305             


Lys Ser  Arg Lys Ser Gly Ser  
    1310                 1315 


<210> 234
<211> 1315
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 234
Ser Ser Gln Cys Val Asn Phe Thr Thr Arg Thr Gln Leu Pro Pro Ala 
1               5                   10                  15      


Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe 
            20                  25                  30          


Arg Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe 
        35                  40                  45              


Ser Asn Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly 
    50                  55                  60                  


Thr Lys Arg Phe Ala Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr 
65                  70                  75                  80  


Phe Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly 
                85                  90                  95      


Thr Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala 
            100                 105                 110         


Thr Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro 
        115                 120                 125             


Phe Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser 
    130                 135                 140                 


Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val 
145                 150                 155                 160 


Ser Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys 
                165                 170                 175     


Asn Leu Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile 
            180                 185                 190         


Tyr Ser Lys His Thr Pro Ile Asn Leu Val Arg Gly Leu Pro Gln Gly 
        195                 200                 205             


Phe Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile 
    210                 215                 220                 


Thr Arg Phe Gln Thr Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser 
225                 230                 235                 240 


Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu 
                245                 250                 255     


Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr 
            260                 265                 270         


Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr 
        275                 280                 285             


Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe 
    290                 295                 300                 


Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn 
305                 310                 315                 320 


Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val 
                325                 330                 335     


Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser 
            340                 345                 350         


Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val 
        355                 360                 365             


Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp 
    370                 375                 380                 


Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln 
385                 390                 395                 400 


Thr Gly Asn Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr 
                405                 410                 415     


Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly 
            420                 425                 430         


Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys 
        435                 440                 445             


Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr 
    450                 455                 460                 


Pro Cys Asn Gly Val Lys Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser 
465                 470                 475                 480 


Tyr Gly Phe Gln Pro Thr Tyr Gly Val Gly Tyr Gln Pro Tyr Arg Val 
                485                 490                 495     


Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly 
            500                 505                 510         


Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn 
        515                 520                 525             


Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys 
    530                 535                 540                 


Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp 
545                 550                 555                 560 


Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys 
                565                 570                 575     


Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn 
            580                 585                 590         


Gln Val Ala Val Leu Tyr Gln Gly Val Asn Cys Thr Glu Val Pro Val 
        595                 600                 605             


Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr 
    610                 615                 620                 


Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu 
625                 630                 635                 640 


His Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile 
                645                 650                 655     


Cys Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro Gly Ser Ala Ser Ser 
            660                 665                 670         


Val Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Val Glu 
        675                 680                 685             


Asn Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe 
    690                 695                 700                 


Thr Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr 
705                 710                 715                 720 


Ser Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser 
                725                 730                 735     


Asn Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala 
            740                 745                 750         


Leu Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe 
        755                 760                 765             


Ala Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly 
    770                 775                 780                 


Gly Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys 
785                 790                 795                 800 


Arg Ser Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp 
                805                 810                 815     


Ala Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala 
            820                 825                 830         


Arg Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro 
        835                 840                 845             


Pro Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu 
    850                 855                 860                 


Ala Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu 
865                 870                 875                 880 


Gln Ile Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly 
                885                 890                 895     


Val Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln 
            900                 905                 910         


Phe Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala 
        915                 920                 925             


Ser Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala 
    930                 935                 940                 


Leu Asn Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser 
945                 950                 955                 960 


Ser Val Leu Asn Asp Ile Leu Ser Arg Leu Asp Pro Pro Glu Ala Glu 
                965                 970                 975     


Val Gln Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser Leu Gln Thr 
            980                 985                 990         


Tyr Val Thr Gln Gln Leu Ile Arg  Ala Ala Glu Ile Arg  Ala Ser Ala 
        995                 1000                 1005             


Asn Leu  Ala Ala Thr Lys Met  Ser Glu Cys Val Leu  Gly Gln Ser 
    1010                 1015                 1020             


Lys Arg  Val Asp Phe Cys Gly  Lys Gly Tyr His Leu  Met Ser Phe 
    1025                 1030                 1035             


Pro Gln  Ser Ala Pro His Gly  Val Val Phe Leu His  Val Thr Tyr 
    1040                 1045                 1050             


Val Pro  Ala Gln Glu Lys Asn  Phe Thr Thr Ala Pro  Ala Ile Cys 
    1055                 1060                 1065             


His Asp  Gly Lys Ala His Phe  Pro Arg Glu Gly Val  Phe Val Ser 
    1070                 1075                 1080             


Asn Gly  Thr His Trp Phe Val  Thr Gln Arg Asn Phe  Tyr Glu Pro 
    1085                 1090                 1095             


Gln Ile  Ile Thr Thr Asp Asn  Thr Phe Val Ser Gly  Asn Cys Asp 
    1100                 1105                 1110             


Val Val  Ile Gly Ile Val Asn  Asn Thr Val Tyr Asp  Pro Leu Gln 
    1115                 1120                 1125             


Ser Glu  Leu Asp Ser Ile Lys  Glu Glu Leu Asp Lys  Ile His Lys 
    1130                 1135                 1140             


Asn Gly  Ser Gly Gly Ser Gly  Asp Ile Ile Lys Leu  Leu Asn Glu 
    1145                 1150                 1155             


Gln Val  Asn Lys Glu Met Gln  Ser Ser Asn Leu Tyr  Met Ser Met 
    1160                 1165                 1170             


Ser Ser  Trp Cys Tyr Thr His  Ser Leu Asp Gly Ala  Gly Leu Phe 
    1175                 1180                 1185             


Leu Phe  Asp His Ala Ala Glu  Glu Tyr Glu His Ala  Lys Lys Leu 
    1190                 1195                 1200             


Ile Ile  Phe Leu Asn Glu Asn  Asn Val Pro Val Gln  Leu Thr Ser 
    1205                 1210                 1215             


Ile Ser  Ala Pro Glu His Lys  Phe Glu Gly Leu Thr  Gln Ile Phe 
    1220                 1225                 1230             


Gln Lys  Ala Tyr Glu His Glu  Gln His Ile Ser Glu  Ser Ile Asn 
    1235                 1240                 1245             


Asn Ile  Val Asp His Ala Ile  Lys Ser Lys Asp His  Ala Thr Phe 
    1250                 1255                 1260             


Asn Phe  Leu Gln Trp Tyr Val  Ala Glu Gln His Glu  Glu Glu Val 
    1265                 1270                 1275             


Leu Phe  Lys Asp Ile Leu Asp  Lys Ile Glu Leu Ile  Gly Asn Glu 
    1280                 1285                 1290             


Asn His  Gly Leu Tyr Leu Ala  Asp Gln Tyr Val Lys  Gly Ile Ala 
    1295                 1300                 1305             


Lys Ser  Arg Lys Ser Gly Ser  
    1310                 1315 


<210> 235
<211> 1315
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 235
Ser Ser Gln Cys Val Asn Phe Thr Thr Arg Thr Gln Leu Pro Pro Ala 
1               5                   10                  15      


Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe 
            20                  25                  30          


Arg Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe 
        35                  40                  45              


Ser Asn Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly 
    50                  55                  60                  


Thr Lys Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr 
65                  70                  75                  80  


Phe Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly 
                85                  90                  95      


Thr Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala 
            100                 105                 110         


Thr Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro 
        115                 120                 125             


Phe Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser 
    130                 135                 140                 


Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val 
145                 150                 155                 160 


Ser Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys 
                165                 170                 175     


Asn Leu Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile 
            180                 185                 190         


Tyr Ser Lys His Thr Pro Ile Asn Leu Val Arg Gly Leu Pro Gln Gly 
        195                 200                 205             


Phe Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile 
    210                 215                 220                 


Thr Arg Phe Gln Thr Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser 
225                 230                 235                 240 


Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu 
                245                 250                 255     


Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr 
            260                 265                 270         


Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr 
        275                 280                 285             


Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe 
    290                 295                 300                 


Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn 
305                 310                 315                 320 


Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val 
                325                 330                 335     


Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser 
            340                 345                 350         


Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val 
        355                 360                 365             


Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp 
    370                 375                 380                 


Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln 
385                 390                 395                 400 


Thr Gly Asn Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr 
                405                 410                 415     


Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly 
            420                 425                 430         


Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys 
        435                 440                 445             


Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr 
    450                 455                 460                 


Pro Cys Asn Gly Val Lys Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser 
465                 470                 475                 480 


Tyr Gly Phe Gln Pro Thr Tyr Gly Val Gly Tyr Gln Pro Tyr Arg Val 
                485                 490                 495     


Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly 
            500                 505                 510         


Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn 
        515                 520                 525             


Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys 
    530                 535                 540                 


Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp 
545                 550                 555                 560 


Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys 
                565                 570                 575     


Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn 
            580                 585                 590         


Gln Val Ala Val Leu Tyr Gln Gly Val Asn Cys Thr Glu Val Pro Val 
        595                 600                 605             


Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr 
    610                 615                 620                 


Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu 
625                 630                 635                 640 


His Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile 
                645                 650                 655     


Cys Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro Gly Ser Ala Ser Ser 
            660                 665                 670         


Val Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Val Glu 
        675                 680                 685             


Asn Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe 
    690                 695                 700                 


Thr Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr 
705                 710                 715                 720 


Ser Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser 
                725                 730                 735     


Asn Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala 
            740                 745                 750         


Leu Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe 
        755                 760                 765             


Ala Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly 
    770                 775                 780                 


Gly Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys 
785                 790                 795                 800 


Arg Ser Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp 
                805                 810                 815     


Ala Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala 
            820                 825                 830         


Arg Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro 
        835                 840                 845             


Pro Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu 
    850                 855                 860                 


Ala Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu 
865                 870                 875                 880 


Gln Ile Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly 
                885                 890                 895     


Val Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln 
            900                 905                 910         


Phe Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala 
        915                 920                 925             


Ser Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala 
    930                 935                 940                 


Leu Asn Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser 
945                 950                 955                 960 


Ser Val Leu Asn Asp Ile Leu Ser Arg Leu Asp Pro Pro Glu Ala Glu 
                965                 970                 975     


Val Gln Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser Leu Gln Thr 
            980                 985                 990         


Tyr Val Thr Gln Gln Leu Ile Arg  Ala Ala Glu Ile Arg  Ala Ser Ala 
        995                 1000                 1005             


Asn Leu  Ala Ala Thr Lys Met  Ser Glu Cys Val Leu  Gly Gln Ser 
    1010                 1015                 1020             


Lys Arg  Val Asp Phe Cys Gly  Lys Gly Tyr His Leu  Met Ser Phe 
    1025                 1030                 1035             


Pro Gln  Ser Ala Pro His Gly  Val Val Phe Leu His  Val Thr Tyr 
    1040                 1045                 1050             


Val Pro  Ala Gln Glu Lys Asn  Phe Thr Thr Ala Pro  Ala Ile Cys 
    1055                 1060                 1065             


His Asp  Gly Lys Ala His Phe  Pro Arg Glu Gly Val  Phe Val Ser 
    1070                 1075                 1080             


Asn Gly  Thr His Trp Phe Val  Thr Gln Arg Asn Phe  Tyr Glu Pro 
    1085                 1090                 1095             


Gln Ile  Ile Thr Thr Asp Asn  Thr Phe Val Ser Gly  Asn Cys Asp 
    1100                 1105                 1110             


Val Val  Ile Gly Ile Val Asn  Asn Thr Val Tyr Asp  Pro Leu Gln 
    1115                 1120                 1125             


Ser Glu  Leu Asp Ser Ile Lys  Glu Glu Leu Asp Lys  Ile His Lys 
    1130                 1135                 1140             


Asn Gly  Ser Gly Gly Ser Gly  Asp Ile Ile Lys Leu  Leu Asn Glu 
    1145                 1150                 1155             


Gln Val  Asn Lys Glu Met Gln  Ser Ser Asn Leu Tyr  Met Ser Met 
    1160                 1165                 1170             


Ser Ser  Trp Cys Tyr Thr His  Ser Leu Asp Gly Ala  Gly Leu Phe 
    1175                 1180                 1185             


Leu Phe  Asp His Ala Ala Glu  Glu Tyr Glu His Ala  Lys Lys Leu 
    1190                 1195                 1200             


Ile Ile  Phe Leu Asn Glu Asn  Asn Val Pro Val Gln  Leu Thr Ser 
    1205                 1210                 1215             


Ile Ser  Ala Pro Glu His Lys  Phe Glu Gly Leu Thr  Gln Ile Phe 
    1220                 1225                 1230             


Gln Lys  Ala Tyr Glu His Glu  Gln His Ile Ser Glu  Ser Ile Asn 
    1235                 1240                 1245             


Asn Ile  Val Asp His Ala Ile  Lys Ser Lys Asp His  Ala Thr Phe 
    1250                 1255                 1260             


Asn Phe  Leu Gln Trp Tyr Val  Ala Glu Gln His Glu  Glu Glu Val 
    1265                 1270                 1275             


Leu Phe  Lys Asp Ile Leu Asp  Lys Ile Glu Leu Ile  Gly Asn Glu 
    1280                 1285                 1290             


Asn His  Gly Leu Tyr Leu Ala  Asp Gln Tyr Val Lys  Gly Ile Ala 
    1295                 1300                 1305             


Lys Ser  Arg Lys Ser Gly Ser  
    1310                 1315 


<210> 236
<211> 1315
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 236
Ser Ser Gln Cys Val Asn Phe Thr Thr Arg Thr Gln Leu Pro Pro Ala 
1               5                   10                  15      


Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe 
            20                  25                  30          


Arg Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe 
        35                  40                  45              


Ser Asn Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly 
    50                  55                  60                  


Thr Lys Arg Phe Ala Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr 
65                  70                  75                  80  


Phe Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly 
                85                  90                  95      


Thr Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala 
            100                 105                 110         


Thr Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro 
        115                 120                 125             


Phe Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser 
    130                 135                 140                 


Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val 
145                 150                 155                 160 


Ser Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys 
                165                 170                 175     


Asn Leu Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile 
            180                 185                 190         


Tyr Ser Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly 
        195                 200                 205             


Phe Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile 
    210                 215                 220                 


Thr Arg Phe Gln Thr Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser 
225                 230                 235                 240 


Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu 
                245                 250                 255     


Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr 
            260                 265                 270         


Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr 
        275                 280                 285             


Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe 
    290                 295                 300                 


Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn 
305                 310                 315                 320 


Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val 
                325                 330                 335     


Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser 
            340                 345                 350         


Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val 
        355                 360                 365             


Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp 
    370                 375                 380                 


Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln 
385                 390                 395                 400 


Thr Gly Asn Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr 
                405                 410                 415     


Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly 
            420                 425                 430         


Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys 
        435                 440                 445             


Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr 
    450                 455                 460                 


Pro Cys Asn Gly Val Lys Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser 
465                 470                 475                 480 


Tyr Gly Phe Gln Pro Thr Tyr Gly Val Gly Tyr Gln Pro Tyr Arg Val 
                485                 490                 495     


Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly 
            500                 505                 510         


Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn 
        515                 520                 525             


Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys 
    530                 535                 540                 


Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp 
545                 550                 555                 560 


Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys 
                565                 570                 575     


Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn 
            580                 585                 590         


Gln Val Ala Val Leu Tyr Gln Gly Val Asn Cys Thr Glu Val Pro Val 
        595                 600                 605             


Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr 
    610                 615                 620                 


Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu 
625                 630                 635                 640 


His Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile 
                645                 650                 655     


Cys Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro Gly Ser Ala Ser Ser 
            660                 665                 670         


Val Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Val Glu 
        675                 680                 685             


Asn Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe 
    690                 695                 700                 


Thr Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr 
705                 710                 715                 720 


Ser Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser 
                725                 730                 735     


Asn Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala 
            740                 745                 750         


Leu Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe 
        755                 760                 765             


Ala Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly 
    770                 775                 780                 


Gly Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys 
785                 790                 795                 800 


Arg Ser Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp 
                805                 810                 815     


Ala Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala 
            820                 825                 830         


Arg Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro 
        835                 840                 845             


Pro Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu 
    850                 855                 860                 


Ala Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu 
865                 870                 875                 880 


Gln Ile Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly 
                885                 890                 895     


Val Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln 
            900                 905                 910         


Phe Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala 
        915                 920                 925             


Ser Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala 
    930                 935                 940                 


Leu Asn Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser 
945                 950                 955                 960 


Ser Val Leu Asn Asp Ile Leu Ser Arg Leu Asp Pro Pro Glu Ala Glu 
                965                 970                 975     


Val Gln Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser Leu Gln Thr 
            980                 985                 990         


Tyr Val Thr Gln Gln Leu Ile Arg  Ala Ala Glu Ile Arg  Ala Ser Ala 
        995                 1000                 1005             


Asn Leu  Ala Ala Thr Lys Met  Ser Glu Cys Val Leu  Gly Gln Ser 
    1010                 1015                 1020             


Lys Arg  Val Asp Phe Cys Gly  Lys Gly Tyr His Leu  Met Ser Phe 
    1025                 1030                 1035             


Pro Gln  Ser Ala Pro His Gly  Val Val Phe Leu His  Val Thr Tyr 
    1040                 1045                 1050             


Val Pro  Ala Gln Glu Lys Asn  Phe Thr Thr Ala Pro  Ala Ile Cys 
    1055                 1060                 1065             


His Asp  Gly Lys Ala His Phe  Pro Arg Glu Gly Val  Phe Val Ser 
    1070                 1075                 1080             


Asn Gly  Thr His Trp Phe Val  Thr Gln Arg Asn Phe  Tyr Glu Pro 
    1085                 1090                 1095             


Gln Ile  Ile Thr Thr Asp Asn  Thr Phe Val Ser Gly  Asn Cys Asp 
    1100                 1105                 1110             


Val Val  Ile Gly Ile Val Asn  Asn Thr Val Tyr Asp  Pro Leu Gln 
    1115                 1120                 1125             


Ser Glu  Leu Asp Ser Ile Lys  Glu Glu Leu Asp Lys  Ile His Lys 
    1130                 1135                 1140             


Asn Gly  Ser Gly Gly Ser Gly  Asp Ile Ile Lys Leu  Leu Asn Glu 
    1145                 1150                 1155             


Gln Val  Asn Lys Glu Met Gln  Ser Ser Asn Leu Tyr  Met Ser Met 
    1160                 1165                 1170             


Ser Ser  Trp Cys Tyr Thr His  Ser Leu Asp Gly Ala  Gly Leu Phe 
    1175                 1180                 1185             


Leu Phe  Asp His Ala Ala Glu  Glu Tyr Glu His Ala  Lys Lys Leu 
    1190                 1195                 1200             


Ile Ile  Phe Leu Asn Glu Asn  Asn Val Pro Val Gln  Leu Thr Ser 
    1205                 1210                 1215             


Ile Ser  Ala Pro Glu His Lys  Phe Glu Gly Leu Thr  Gln Ile Phe 
    1220                 1225                 1230             


Gln Lys  Ala Tyr Glu His Glu  Gln His Ile Ser Glu  Ser Ile Asn 
    1235                 1240                 1245             


Asn Ile  Val Asp His Ala Ile  Lys Ser Lys Asp His  Ala Thr Phe 
    1250                 1255                 1260             


Asn Phe  Leu Gln Trp Tyr Val  Ala Glu Gln His Glu  Glu Glu Val 
    1265                 1270                 1275             


Leu Phe  Lys Asp Ile Leu Asp  Lys Ile Glu Leu Ile  Gly Asn Glu 
    1280                 1285                 1290             


Asn His  Gly Leu Tyr Leu Ala  Asp Gln Tyr Val Lys  Gly Ile Ala 
    1295                 1300                 1305             


Lys Ser  Arg Lys Ser Gly Ser  
    1310                 1315 


<210> 237
<211> 1318
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 237
Ser Ser Gln Cys Val Asn Phe Thr Asn Arg Thr Gln Leu Pro Ser Ala 
1               5                   10                  15      


Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe 
            20                  25                  30          


Arg Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe 
        35                  40                  45              


Ser Asn Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly 
    50                  55                  60                  


Thr Lys Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr 
65                  70                  75                  80  


Phe Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly 
                85                  90                  95      


Thr Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala 
            100                 105                 110         


Thr Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Tyr Pro 
        115                 120                 125             


Phe Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser 
    130                 135                 140                 


Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val 
145                 150                 155                 160 


Ser Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys 
                165                 170                 175     


Asn Leu Ser Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile 
            180                 185                 190         


Tyr Ser Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly 
        195                 200                 205             


Phe Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile 
    210                 215                 220                 


Thr Arg Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro 
225                 230                 235                 240 


Gly Asp Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val 
                245                 250                 255     


Gly Tyr Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly 
            260                 265                 270         


Thr Ile Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr 
        275                 280                 285             


Lys Cys Thr Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr 
    290                 295                 300                 


Ser Asn Phe Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn 
305                 310                 315                 320 


Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe 
                325                 330                 335     


Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala 
            340                 345                 350         


Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys 
        355                 360                 365             


Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val 
    370                 375                 380                 


Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala 
385                 390                 395                 400 


Pro Gly Gln Thr Gly Thr Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp 
                405                 410                 415     


Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser 
            420                 425                 430         


Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser 
        435                 440                 445             


Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala 
    450                 455                 460                 


Gly Ser Thr Pro Cys Asn Gly Val Lys Gly Phe Asn Cys Tyr Phe Pro 
465                 470                 475                 480 


Leu Gln Ser Tyr Gly Phe Gln Pro Thr Tyr Gly Val Gly Tyr Gln Pro 
                485                 490                 495     


Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr 
            500                 505                 510         


Val Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val 
        515                 520                 525             


Asn Phe Asn Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser 
    530                 535                 540                 


Asn Lys Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp 
545                 550                 555                 560 


Thr Thr Asp Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile 
                565                 570                 575     


Thr Pro Cys Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn 
            580                 585                 590         


Thr Ser Asn Gln Val Ala Val Leu Tyr Gln Gly Val Asn Cys Thr Glu 
        595                 600                 605             


Val Pro Val Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val 
    610                 615                 620                 


Tyr Ser Thr Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile 
625                 630                 635                 640 


Gly Ala Glu Tyr Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly 
                645                 650                 655     


Ala Gly Ile Cys Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro Gly Ser 
            660                 665                 670         


Ala Ser Ser Val Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu 
        675                 680                 685             


Gly Ala Glu Asn Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro 
    690                 695                 700                 


Thr Asn Phe Thr Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met 
705                 710                 715                 720 


Thr Lys Thr Ser Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr 
                725                 730                 735     


Glu Cys Ser Asn Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu 
            740                 745                 750         


Asn Arg Ala Leu Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln 
        755                 760                 765             


Glu Val Phe Ala Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys 
    770                 775                 780                 


Asp Phe Gly Gly Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys 
785                 790                 795                 800 


Pro Ser Lys Arg Ser Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr 
                805                 810                 815     


Leu Ala Asp Ala Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp 
            820                 825                 830         


Ile Ala Ala Arg Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr 
        835                 840                 845             


Val Leu Pro Pro Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser 
    850                 855                 860                 


Ala Leu Leu Ala Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly 
865                 870                 875                 880 


Ala Ala Leu Gln Ile Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn 
                885                 890                 895     


Gly Ile Gly Val Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile 
            900                 905                 910         


Ala Asn Gln Phe Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser 
        915                 920                 925             


Ser Thr Ala Ser Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn 
    930                 935                 940                 


Ala Gln Ala Leu Asn Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly 
945                 950                 955                 960 


Ala Ile Ser Ser Val Leu Asn Asp Ile Leu Ser Arg Leu Asp Pro Pro 
                965                 970                 975     


Glu Ala Glu Val Gln Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser 
            980                 985                 990         


Leu Gln Thr Tyr Val Thr Gln Gln  Leu Ile Arg Ala Ala  Glu Ile Arg 
        995                 1000                 1005             


Ala Ser  Ala Asn Leu Ala Ala  Ile Lys Met Ser Glu  Cys Val Leu 
    1010                 1015                 1020             


Gly Gln  Ser Lys Arg Val Asp  Phe Cys Gly Lys Gly  Tyr His Leu 
    1025                 1030                 1035             


Met Ser  Phe Pro Gln Ser Ala  Pro His Gly Val Val  Phe Leu His 
    1040                 1045                 1050             


Val Thr  Tyr Val Pro Ala Gln  Glu Lys Asn Phe Thr  Thr Ala Pro 
    1055                 1060                 1065             


Ala Ile  Cys His Asp Gly Lys  Ala His Phe Pro Arg  Glu Gly Val 
    1070                 1075                 1080             


Phe Val  Ser Asn Gly Thr His  Trp Phe Val Thr Gln  Arg Asn Phe 
    1085                 1090                 1095             


Tyr Glu  Pro Gln Ile Ile Thr  Thr Asp Asn Thr Phe  Val Ser Gly 
    1100                 1105                 1110             


Asn Cys  Asp Val Val Ile Gly  Ile Val Asn Asn Thr  Val Tyr Asp 
    1115                 1120                 1125             


Pro Leu  Gln Ser Glu Leu Asp  Ser Ile Lys Glu Glu  Leu Asp Lys 
    1130                 1135                 1140             


Ile His  Lys Asn Gly Ser Gly  Gly Ser Gly Asp Ile  Ile Lys Leu 
    1145                 1150                 1155             


Leu Asn  Glu Gln Val Asn Lys  Glu Met Gln Ser Ser  Asn Leu Tyr 
    1160                 1165                 1170             


Met Ser  Met Ser Ser Trp Cys  Tyr Thr His Ser Leu  Asp Gly Ala 
    1175                 1180                 1185             


Gly Leu  Phe Leu Phe Asp His  Ala Ala Glu Glu Tyr  Glu His Ala 
    1190                 1195                 1200             


Lys Lys  Leu Ile Ile Phe Leu  Asn Glu Asn Asn Val  Pro Val Gln 
    1205                 1210                 1215             


Leu Thr  Ser Ile Ser Ala Pro  Glu His Lys Phe Glu  Gly Leu Thr 
    1220                 1225                 1230             


Gln Ile  Phe Gln Lys Ala Tyr  Glu His Glu Gln His  Ile Ser Glu 
    1235                 1240                 1245             


Ser Ile  Asn Asn Ile Val Asp  His Ala Ile Lys Ser  Lys Asp His 
    1250                 1255                 1260             


Ala Thr  Phe Asn Phe Leu Gln  Trp Tyr Val Ala Glu  Gln His Glu 
    1265                 1270                 1275             


Glu Glu  Val Leu Phe Lys Asp  Ile Leu Asp Lys Ile  Glu Leu Ile 
    1280                 1285                 1290             


Gly Asn  Glu Asn His Gly Leu  Tyr Leu Ala Asp Gln  Tyr Val Lys 
    1295                 1300                 1305             


Gly Ile  Ala Lys Ser Arg Lys  Ser Gly Ser 
    1310                 1315             


<210> 238
<211> 1329
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 238
Ser Ser Gln Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala 
1               5                   10                  15      


Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe 
            20                  25                  30          


Arg Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe 
        35                  40                  45              


Ser Asn Val Thr Trp Phe His Ala Ile Ser Gly Thr Asn Gly Thr Lys 
    50                  55                  60                  


Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala 
65                  70                  75                  80  


Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr 
                85                  90                  95      


Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn 
            100                 105                 110         


Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu 
        115                 120                 125             


Gly Val Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg 
    130                 135                 140                 


Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro 
145                 150                 155                 160 


Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg 
                165                 170                 175     


Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys 
            180                 185                 190         


His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala 
        195                 200                 205             


Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe 
    210                 215                 220                 


Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser 
225                 230                 235                 240 


Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu 
                245                 250                 255     


Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr 
            260                 265                 270         


Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr 
        275                 280                 285             


Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe 
    290                 295                 300                 


Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn 
305                 310                 315                 320 


Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val 
                325                 330                 335     


Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser 
            340                 345                 350         


Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val 
        355                 360                 365             


Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp 
    370                 375                 380                 


Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln 
385                 390                 395                 400 


Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr 
                405                 410                 415     


Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly 
            420                 425                 430         


Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys 
        435                 440                 445             


Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr 
    450                 455                 460                 


Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser 
465                 470                 475                 480 


Tyr Gly Phe Gln Pro Thr Tyr Gly Val Gly Tyr Gln Pro Tyr Arg Val 
                485                 490                 495     


Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly 
            500                 505                 510         


Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn 
        515                 520                 525             


Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys 
    530                 535                 540                 


Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Asp Asp Thr Thr Asp 
545                 550                 555                 560 


Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys 
                565                 570                 575     


Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn 
            580                 585                 590         


Gln Val Ala Val Leu Tyr Gln Gly Val Asn Cys Thr Glu Val Pro Val 
        595                 600                 605             


Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr 
    610                 615                 620                 


Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu 
625                 630                 635                 640 


His Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile 
                645                 650                 655     


Cys Ala Ser Tyr Gln Thr Gln Thr Asn Ser His Gly Ser Ala Ser Ser 
            660                 665                 670         


Val Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu 
        675                 680                 685             


Asn Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Ile Asn Phe 
    690                 695                 700                 


Thr Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr 
705                 710                 715                 720 


Ser Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser 
                725                 730                 735     


Asn Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala 
            740                 745                 750         


Leu Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe 
        755                 760                 765             


Ala Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly 
    770                 775                 780                 


Gly Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys 
785                 790                 795                 800 


Arg Ser Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp 
                805                 810                 815     


Ala Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala 
            820                 825                 830         


Arg Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro 
        835                 840                 845             


Pro Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu 
    850                 855                 860                 


Ala Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu 
865                 870                 875                 880 


Gln Ile Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly 
                885                 890                 895     


Val Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln 
            900                 905                 910         


Phe Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala 
        915                 920                 925             


Ser Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala 
    930                 935                 940                 


Leu Asn Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser 
945                 950                 955                 960 


Ser Val Leu Asn Asp Ile Leu Ala Arg Leu Asp Pro Pro Glu Ala Glu 
                965                 970                 975     


Val Gln Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser Leu Gln Thr 
            980                 985                 990         


Tyr Val Thr Gln Gln Leu Ile Arg  Ala Ala Glu Ile Arg  Ala Ser Ala 
        995                 1000                 1005             


Asn Leu  Ala Ala Thr Lys Met  Ser Glu Cys Val Leu  Gly Gln Ser 
    1010                 1015                 1020             


Lys Arg  Val Asp Phe Cys Gly  Lys Gly Tyr His Leu  Met Ser Phe 
    1025                 1030                 1035             


Pro Gln  Ser Ala Pro His Gly  Val Val Phe Leu His  Val Thr Tyr 
    1040                 1045                 1050             


Val Pro  Ala Gln Glu Lys Asn  Phe Thr Thr Ala Pro  Ala Ile Cys 
    1055                 1060                 1065             


His Asp  Gly Lys Ala His Phe  Pro Arg Glu Gly Val  Phe Val Ser 
    1070                 1075                 1080             


Asn Gly  Thr His Trp Phe Val  Thr Gln Arg Asn Phe  Tyr Glu Pro 
    1085                 1090                 1095             


Gln Ile  Ile Thr Thr His Asn  Thr Phe Val Ser Gly  Asn Cys Asp 
    1100                 1105                 1110             


Val Val  Ile Gly Ile Val Asn  Asn Thr Val Tyr Asp  Pro Leu Gln 
    1115                 1120                 1125             


Ser Glu  Leu Asp Ser Ile Lys  Glu Glu Leu Asp Lys  Ile His Lys 
    1130                 1135                 1140             


Asn Leu  Asp Ser Ile Lys Glu  Glu Leu Asp Lys Ile  His Lys Asn 
    1145                 1150                 1155             


Gly Ser  Gly Gly Ser Gly Asp  Ile Ile Lys Leu Leu  Asn Glu Gln 
    1160                 1165                 1170             


Val Asn  Lys Glu Met Gln Ser  Ser Asn Leu Tyr Met  Ser Met Ser 
    1175                 1180                 1185             


Ser Trp  Cys Tyr Thr His Ser  Leu Asp Gly Ala Gly  Leu Phe Leu 
    1190                 1195                 1200             


Phe Asp  His Ala Ala Glu Glu  Tyr Glu His Ala Lys  Lys Leu Ile 
    1205                 1210                 1215             


Ile Phe  Leu Asn Glu Asn Asn  Val Pro Val Gln Leu  Thr Ser Ile 
    1220                 1225                 1230             


Ser Ala  Pro Glu His Lys Phe  Glu Gly Leu Thr Gln  Ile Phe Gln 
    1235                 1240                 1245             


Lys Ala  Tyr Glu His Glu Gln  His Ile Ser Glu Ser  Ile Asn Asn 
    1250                 1255                 1260             


Ile Val  Asp His Ala Ile Lys  Ser Lys Asp His Ala  Thr Phe Asn 
    1265                 1270                 1275             


Phe Leu  Gln Trp Tyr Val Ala  Glu Gln His Glu Glu  Glu Val Leu 
    1280                 1285                 1290             


Phe Lys  Asp Ile Leu Asp Lys  Ile Glu Leu Ile Gly  Asn Glu Asn 
    1295                 1300                 1305             


His Gly  Leu Tyr Leu Ala Asp  Gln Tyr Val Lys Gly  Ile Ala Lys 
    1310                 1315                 1320             


Ser Arg  Lys Ser Gly Ser 
    1325                 


<210> 239
<211> 1329
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 239
Ser Ser Gln Cys Val Asn Phe Thr Thr Arg Thr Gln Leu Pro Pro Ala 
1               5                   10                  15      


Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe 
            20                  25                  30          


Arg Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe 
        35                  40                  45              


Ser Asn Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly 
    50                  55                  60                  


Thr Lys Arg Phe Ala Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr 
65                  70                  75                  80  


Phe Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly 
                85                  90                  95      


Thr Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala 
            100                 105                 110         


Thr Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro 
        115                 120                 125             


Phe Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser 
    130                 135                 140                 


Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val 
145                 150                 155                 160 


Ser Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys 
                165                 170                 175     


Asn Leu Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile 
            180                 185                 190         


Tyr Ser Lys His Thr Pro Ile Asn Leu Val Arg Gly Leu Pro Gln Gly 
        195                 200                 205             


Phe Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile 
    210                 215                 220                 


Thr Arg Phe Gln Thr Leu His Ile Ser Tyr Leu Thr Pro Gly Asp Ser 
225                 230                 235                 240 


Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu 
                245                 250                 255     


Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr 
            260                 265                 270         


Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr 
        275                 280                 285             


Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe 
    290                 295                 300                 


Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn 
305                 310                 315                 320 


Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val 
                325                 330                 335     


Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser 
            340                 345                 350         


Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val 
        355                 360                 365             


Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp 
    370                 375                 380                 


Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln 
385                 390                 395                 400 


Thr Gly Asn Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr 
                405                 410                 415     


Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly 
            420                 425                 430         


Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys 
        435                 440                 445             


Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr 
    450                 455                 460                 


Pro Cys Asn Gly Val Lys Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser 
465                 470                 475                 480 


Tyr Gly Phe Gln Pro Thr Tyr Gly Val Gly Tyr Gln Pro Tyr Arg Val 
                485                 490                 495     


Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly 
            500                 505                 510         


Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn 
        515                 520                 525             


Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys 
    530                 535                 540                 


Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp 
545                 550                 555                 560 


Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys 
                565                 570                 575     


Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn 
            580                 585                 590         


Gln Val Ala Val Leu Tyr Gln Gly Val Asn Cys Thr Glu Val Pro Val 
        595                 600                 605             


Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr 
    610                 615                 620                 


Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu 
625                 630                 635                 640 


His Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile 
                645                 650                 655     


Cys Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro Gly Ser Ala Ser Ser 
            660                 665                 670         


Val Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Val Glu 
        675                 680                 685             


Asn Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe 
    690                 695                 700                 


Thr Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr 
705                 710                 715                 720 


Ser Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser 
                725                 730                 735     


Asn Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala 
            740                 745                 750         


Leu Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe 
        755                 760                 765             


Ala Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly 
    770                 775                 780                 


Gly Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys 
785                 790                 795                 800 


Arg Ser Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp 
                805                 810                 815     


Ala Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala 
            820                 825                 830         


Arg Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro 
        835                 840                 845             


Pro Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu 
    850                 855                 860                 


Ala Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu 
865                 870                 875                 880 


Gln Ile Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly 
                885                 890                 895     


Val Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln 
            900                 905                 910         


Phe Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala 
        915                 920                 925             


Ser Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala 
    930                 935                 940                 


Leu Asn Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser 
945                 950                 955                 960 


Ser Val Leu Asn Asp Ile Leu Ser Arg Leu Asp Pro Pro Glu Ala Glu 
                965                 970                 975     


Val Gln Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser Leu Gln Thr 
            980                 985                 990         


Tyr Val Thr Gln Gln Leu Ile Arg  Ala Ala Glu Ile Arg  Ala Ser Ala 
        995                 1000                 1005             


Asn Leu  Ala Ala Thr Lys Met  Ser Glu Cys Val Leu  Gly Gln Ser 
    1010                 1015                 1020             


Lys Arg  Val Asp Phe Cys Gly  Lys Gly Tyr His Leu  Met Ser Phe 
    1025                 1030                 1035             


Pro Gln  Ser Ala Pro His Gly  Val Val Phe Leu His  Val Thr Tyr 
    1040                 1045                 1050             


Val Pro  Ala Gln Glu Lys Asn  Phe Thr Thr Ala Pro  Ala Ile Cys 
    1055                 1060                 1065             


His Asp  Gly Lys Ala His Phe  Pro Arg Glu Gly Val  Phe Val Ser 
    1070                 1075                 1080             


Asn Gly  Thr His Trp Phe Val  Thr Gln Arg Asn Phe  Tyr Glu Pro 
    1085                 1090                 1095             


Gln Ile  Ile Thr Thr Asp Asn  Thr Phe Val Ser Gly  Asn Cys Asp 
    1100                 1105                 1110             


Val Val  Ile Gly Ile Val Asn  Asn Thr Val Tyr Asp  Pro Leu Gln 
    1115                 1120                 1125             


Ser Glu  Leu Asp Ser Ile Lys  Glu Glu Leu Asp Lys  Ile His Lys 
    1130                 1135                 1140             


Asn Leu  Asp Ser Ile Lys Glu  Glu Leu Asp Lys Ile  His Lys Asn 
    1145                 1150                 1155             


Gly Ser  Gly Gly Ser Gly Asp  Ile Ile Lys Leu Leu  Asn Glu Gln 
    1160                 1165                 1170             


Val Asn  Lys Glu Met Gln Ser  Ser Asn Leu Tyr Met  Ser Met Ser 
    1175                 1180                 1185             


Ser Trp  Cys Tyr Thr His Ser  Leu Asp Gly Ala Gly  Leu Phe Leu 
    1190                 1195                 1200             


Phe Asp  His Ala Ala Glu Glu  Tyr Glu His Ala Lys  Lys Leu Ile 
    1205                 1210                 1215             


Ile Phe  Leu Asn Glu Asn Asn  Val Pro Val Gln Leu  Thr Ser Ile 
    1220                 1225                 1230             


Ser Ala  Pro Glu His Lys Phe  Glu Gly Leu Thr Gln  Ile Phe Gln 
    1235                 1240                 1245             


Lys Ala  Tyr Glu His Glu Gln  His Ile Ser Glu Ser  Ile Asn Asn 
    1250                 1255                 1260             


Ile Val  Asp His Ala Ile Lys  Ser Lys Asp His Ala  Thr Phe Asn 
    1265                 1270                 1275             


Phe Leu  Gln Trp Tyr Val Ala  Glu Gln His Glu Glu  Glu Val Leu 
    1280                 1285                 1290             


Phe Lys  Asp Ile Leu Asp Lys  Ile Glu Leu Ile Gly  Asn Glu Asn 
    1295                 1300                 1305             


His Gly  Leu Tyr Leu Ala Asp  Gln Tyr Val Lys Gly  Ile Ala Lys 
    1310                 1315                 1320             


Ser Arg  Lys Ser Gly Ser 
    1325                 


<210> 240
<211> 1329
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 240
Ser Ser Gln Cys Val Asn Phe Thr Thr Arg Thr Gln Leu Pro Pro Ala 
1               5                   10                  15      


Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe 
            20                  25                  30          


Arg Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe 
        35                  40                  45              


Ser Asn Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly 
    50                  55                  60                  


Thr Lys Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr 
65                  70                  75                  80  


Phe Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly 
                85                  90                  95      


Thr Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala 
            100                 105                 110         


Thr Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro 
        115                 120                 125             


Phe Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser 
    130                 135                 140                 


Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val 
145                 150                 155                 160 


Ser Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys 
                165                 170                 175     


Asn Leu Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile 
            180                 185                 190         


Tyr Ser Lys His Thr Pro Ile Asn Leu Val Arg Gly Leu Pro Gln Gly 
        195                 200                 205             


Phe Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile 
    210                 215                 220                 


Thr Arg Phe Gln Thr Leu His Ile Ser Tyr Leu Thr Pro Gly Asp Ser 
225                 230                 235                 240 


Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu 
                245                 250                 255     


Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr 
            260                 265                 270         


Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr 
        275                 280                 285             


Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe 
    290                 295                 300                 


Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn 
305                 310                 315                 320 


Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val 
                325                 330                 335     


Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser 
            340                 345                 350         


Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val 
        355                 360                 365             


Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp 
    370                 375                 380                 


Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln 
385                 390                 395                 400 


Thr Gly Asn Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr 
                405                 410                 415     


Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly 
            420                 425                 430         


Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys 
        435                 440                 445             


Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr 
    450                 455                 460                 


Pro Cys Asn Gly Val Lys Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser 
465                 470                 475                 480 


Tyr Gly Phe Gln Pro Thr Tyr Gly Val Gly Tyr Gln Pro Tyr Arg Val 
                485                 490                 495     


Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly 
            500                 505                 510         


Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn 
        515                 520                 525             


Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys 
    530                 535                 540                 


Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp 
545                 550                 555                 560 


Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys 
                565                 570                 575     


Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn 
            580                 585                 590         


Gln Val Ala Val Leu Tyr Gln Gly Val Asn Cys Thr Glu Val Pro Val 
        595                 600                 605             


Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr 
    610                 615                 620                 


Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu 
625                 630                 635                 640 


His Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile 
                645                 650                 655     


Cys Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro Gly Ser Ala Ser Ser 
            660                 665                 670         


Val Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Val Glu 
        675                 680                 685             


Asn Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe 
    690                 695                 700                 


Thr Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr 
705                 710                 715                 720 


Ser Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser 
                725                 730                 735     


Asn Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala 
            740                 745                 750         


Leu Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe 
        755                 760                 765             


Ala Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly 
    770                 775                 780                 


Gly Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys 
785                 790                 795                 800 


Arg Ser Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp 
                805                 810                 815     


Ala Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala 
            820                 825                 830         


Arg Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro 
        835                 840                 845             


Pro Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu 
    850                 855                 860                 


Ala Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu 
865                 870                 875                 880 


Gln Ile Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly 
                885                 890                 895     


Val Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln 
            900                 905                 910         


Phe Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala 
        915                 920                 925             


Ser Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala 
    930                 935                 940                 


Leu Asn Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser 
945                 950                 955                 960 


Ser Val Leu Asn Asp Ile Leu Ser Arg Leu Asp Pro Pro Glu Ala Glu 
                965                 970                 975     


Val Gln Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser Leu Gln Thr 
            980                 985                 990         


Tyr Val Thr Gln Gln Leu Ile Arg  Ala Ala Glu Ile Arg  Ala Ser Ala 
        995                 1000                 1005             


Asn Leu  Ala Ala Thr Lys Met  Ser Glu Cys Val Leu  Gly Gln Ser 
    1010                 1015                 1020             


Lys Arg  Val Asp Phe Cys Gly  Lys Gly Tyr His Leu  Met Ser Phe 
    1025                 1030                 1035             


Pro Gln  Ser Ala Pro His Gly  Val Val Phe Leu His  Val Thr Tyr 
    1040                 1045                 1050             


Val Pro  Ala Gln Glu Lys Asn  Phe Thr Thr Ala Pro  Ala Ile Cys 
    1055                 1060                 1065             


His Asp  Gly Lys Ala His Phe  Pro Arg Glu Gly Val  Phe Val Ser 
    1070                 1075                 1080             


Asn Gly  Thr His Trp Phe Val  Thr Gln Arg Asn Phe  Tyr Glu Pro 
    1085                 1090                 1095             


Gln Ile  Ile Thr Thr Asp Asn  Thr Phe Val Ser Gly  Asn Cys Asp 
    1100                 1105                 1110             


Val Val  Ile Gly Ile Val Asn  Asn Thr Val Tyr Asp  Pro Leu Gln 
    1115                 1120                 1125             


Ser Glu  Leu Asp Ser Ile Lys  Glu Glu Leu Asp Lys  Ile His Lys 
    1130                 1135                 1140             


Asn Leu  Asp Ser Ile Lys Glu  Glu Leu Asp Lys Ile  His Lys Asn 
    1145                 1150                 1155             


Gly Ser  Gly Gly Ser Gly Asp  Ile Ile Lys Leu Leu  Asn Glu Gln 
    1160                 1165                 1170             


Val Asn  Lys Glu Met Gln Ser  Ser Asn Leu Tyr Met  Ser Met Ser 
    1175                 1180                 1185             


Ser Trp  Cys Tyr Thr His Ser  Leu Asp Gly Ala Gly  Leu Phe Leu 
    1190                 1195                 1200             


Phe Asp  His Ala Ala Glu Glu  Tyr Glu His Ala Lys  Lys Leu Ile 
    1205                 1210                 1215             


Ile Phe  Leu Asn Glu Asn Asn  Val Pro Val Gln Leu  Thr Ser Ile 
    1220                 1225                 1230             


Ser Ala  Pro Glu His Lys Phe  Glu Gly Leu Thr Gln  Ile Phe Gln 
    1235                 1240                 1245             


Lys Ala  Tyr Glu His Glu Gln  His Ile Ser Glu Ser  Ile Asn Asn 
    1250                 1255                 1260             


Ile Val  Asp His Ala Ile Lys  Ser Lys Asp His Ala  Thr Phe Asn 
    1265                 1270                 1275             


Phe Leu  Gln Trp Tyr Val Ala  Glu Gln His Glu Glu  Glu Val Leu 
    1280                 1285                 1290             


Phe Lys  Asp Ile Leu Asp Lys  Ile Glu Leu Ile Gly  Asn Glu Asn 
    1295                 1300                 1305             


His Gly  Leu Tyr Leu Ala Asp  Gln Tyr Val Lys Gly  Ile Ala Lys 
    1310                 1315                 1320             


Ser Arg  Lys Ser Gly Ser 
    1325                 


<210> 241
<211> 1329
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 241
Ser Ser Gln Cys Val Asn Phe Thr Thr Arg Thr Gln Leu Pro Pro Ala 
1               5                   10                  15      


Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe 
            20                  25                  30          


Arg Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe 
        35                  40                  45              


Ser Asn Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly 
    50                  55                  60                  


Thr Lys Arg Phe Ala Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr 
65                  70                  75                  80  


Phe Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly 
                85                  90                  95      


Thr Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala 
            100                 105                 110         


Thr Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro 
        115                 120                 125             


Phe Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser 
    130                 135                 140                 


Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val 
145                 150                 155                 160 


Ser Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys 
                165                 170                 175     


Asn Leu Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile 
            180                 185                 190         


Tyr Ser Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly 
        195                 200                 205             


Phe Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile 
    210                 215                 220                 


Thr Arg Phe Gln Thr Leu His Ile Ser Tyr Leu Thr Pro Gly Asp Ser 
225                 230                 235                 240 


Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu 
                245                 250                 255     


Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr 
            260                 265                 270         


Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr 
        275                 280                 285             


Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe 
    290                 295                 300                 


Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn 
305                 310                 315                 320 


Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val 
                325                 330                 335     


Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser 
            340                 345                 350         


Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val 
        355                 360                 365             


Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp 
    370                 375                 380                 


Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln 
385                 390                 395                 400 


Thr Gly Asn Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr 
                405                 410                 415     


Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly 
            420                 425                 430         


Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys 
        435                 440                 445             


Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr 
    450                 455                 460                 


Pro Cys Asn Gly Val Lys Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser 
465                 470                 475                 480 


Tyr Gly Phe Gln Pro Thr Tyr Gly Val Gly Tyr Gln Pro Tyr Arg Val 
                485                 490                 495     


Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly 
            500                 505                 510         


Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn 
        515                 520                 525             


Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys 
    530                 535                 540                 


Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp 
545                 550                 555                 560 


Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys 
                565                 570                 575     


Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn 
            580                 585                 590         


Gln Val Ala Val Leu Tyr Gln Gly Val Asn Cys Thr Glu Val Pro Val 
        595                 600                 605             


Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr 
    610                 615                 620                 


Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu 
625                 630                 635                 640 


His Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile 
                645                 650                 655     


Cys Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro Gly Ser Ala Ser Ser 
            660                 665                 670         


Val Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Val Glu 
        675                 680                 685             


Asn Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe 
    690                 695                 700                 


Thr Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr 
705                 710                 715                 720 


Ser Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser 
                725                 730                 735     


Asn Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala 
            740                 745                 750         


Leu Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe 
        755                 760                 765             


Ala Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly 
    770                 775                 780                 


Gly Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys 
785                 790                 795                 800 


Arg Ser Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp 
                805                 810                 815     


Ala Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala 
            820                 825                 830         


Arg Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro 
        835                 840                 845             


Pro Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu 
    850                 855                 860                 


Ala Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu 
865                 870                 875                 880 


Gln Ile Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly 
                885                 890                 895     


Val Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln 
            900                 905                 910         


Phe Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala 
        915                 920                 925             


Ser Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala 
    930                 935                 940                 


Leu Asn Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser 
945                 950                 955                 960 


Ser Val Leu Asn Asp Ile Leu Ser Arg Leu Asp Pro Pro Glu Ala Glu 
                965                 970                 975     


Val Gln Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser Leu Gln Thr 
            980                 985                 990         


Tyr Val Thr Gln Gln Leu Ile Arg  Ala Ala Glu Ile Arg  Ala Ser Ala 
        995                 1000                 1005             


Asn Leu  Ala Ala Thr Lys Met  Ser Glu Cys Val Leu  Gly Gln Ser 
    1010                 1015                 1020             


Lys Arg  Val Asp Phe Cys Gly  Lys Gly Tyr His Leu  Met Ser Phe 
    1025                 1030                 1035             


Pro Gln  Ser Ala Pro His Gly  Val Val Phe Leu His  Val Thr Tyr 
    1040                 1045                 1050             


Val Pro  Ala Gln Glu Lys Asn  Phe Thr Thr Ala Pro  Ala Ile Cys 
    1055                 1060                 1065             


His Asp  Gly Lys Ala His Phe  Pro Arg Glu Gly Val  Phe Val Ser 
    1070                 1075                 1080             


Asn Gly  Thr His Trp Phe Val  Thr Gln Arg Asn Phe  Tyr Glu Pro 
    1085                 1090                 1095             


Gln Ile  Ile Thr Thr Asp Asn  Thr Phe Val Ser Gly  Asn Cys Asp 
    1100                 1105                 1110             


Val Val  Ile Gly Ile Val Asn  Asn Thr Val Tyr Asp  Pro Leu Gln 
    1115                 1120                 1125             


Ser Glu  Leu Asp Ser Ile Lys  Glu Glu Leu Asp Lys  Ile His Lys 
    1130                 1135                 1140             


Asn Leu  Asp Ser Ile Lys Glu  Glu Leu Asp Lys Ile  His Lys Asn 
    1145                 1150                 1155             


Gly Ser  Gly Gly Ser Gly Asp  Ile Ile Lys Leu Leu  Asn Glu Gln 
    1160                 1165                 1170             


Val Asn  Lys Glu Met Gln Ser  Ser Asn Leu Tyr Met  Ser Met Ser 
    1175                 1180                 1185             


Ser Trp  Cys Tyr Thr His Ser  Leu Asp Gly Ala Gly  Leu Phe Leu 
    1190                 1195                 1200             


Phe Asp  His Ala Ala Glu Glu  Tyr Glu His Ala Lys  Lys Leu Ile 
    1205                 1210                 1215             


Ile Phe  Leu Asn Glu Asn Asn  Val Pro Val Gln Leu  Thr Ser Ile 
    1220                 1225                 1230             


Ser Ala  Pro Glu His Lys Phe  Glu Gly Leu Thr Gln  Ile Phe Gln 
    1235                 1240                 1245             


Lys Ala  Tyr Glu His Glu Gln  His Ile Ser Glu Ser  Ile Asn Asn 
    1250                 1255                 1260             


Ile Val  Asp His Ala Ile Lys  Ser Lys Asp His Ala  Thr Phe Asn 
    1265                 1270                 1275             


Phe Leu  Gln Trp Tyr Val Ala  Glu Gln His Glu Glu  Glu Val Leu 
    1280                 1285                 1290             


Phe Lys  Asp Ile Leu Asp Lys  Ile Glu Leu Ile Gly  Asn Glu Asn 
    1295                 1300                 1305             


His Gly  Leu Tyr Leu Ala Asp  Gln Tyr Val Lys Gly  Ile Ala Lys 
    1310                 1315                 1320             


Ser Arg  Lys Ser Gly Ser 
    1325                 


<210> 242
<211> 1329
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 242
Ser Ser Gln Cys Val Asn Phe Thr Thr Arg Thr Gln Leu Pro Pro Ala 
1               5                   10                  15      


Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe 
            20                  25                  30          


Arg Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe 
        35                  40                  45              


Ser Asn Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly 
    50                  55                  60                  


Thr Lys Arg Phe Ala Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr 
65                  70                  75                  80  


Phe Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly 
                85                  90                  95      


Thr Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala 
            100                 105                 110         


Thr Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro 
        115                 120                 125             


Phe Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser 
    130                 135                 140                 


Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val 
145                 150                 155                 160 


Ser Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys 
                165                 170                 175     


Asn Leu Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile 
            180                 185                 190         


Tyr Ser Lys His Thr Pro Ile Asn Leu Val Arg Gly Leu Pro Gln Gly 
        195                 200                 205             


Phe Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile 
    210                 215                 220                 


Thr Arg Phe Gln Thr Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser 
225                 230                 235                 240 


Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu 
                245                 250                 255     


Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr 
            260                 265                 270         


Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr 
        275                 280                 285             


Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe 
    290                 295                 300                 


Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn 
305                 310                 315                 320 


Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val 
                325                 330                 335     


Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser 
            340                 345                 350         


Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val 
        355                 360                 365             


Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp 
    370                 375                 380                 


Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln 
385                 390                 395                 400 


Thr Gly Asn Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr 
                405                 410                 415     


Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly 
            420                 425                 430         


Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys 
        435                 440                 445             


Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr 
    450                 455                 460                 


Pro Cys Asn Gly Val Lys Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser 
465                 470                 475                 480 


Tyr Gly Phe Gln Pro Thr Tyr Gly Val Gly Tyr Gln Pro Tyr Arg Val 
                485                 490                 495     


Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly 
            500                 505                 510         


Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn 
        515                 520                 525             


Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys 
    530                 535                 540                 


Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp 
545                 550                 555                 560 


Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys 
                565                 570                 575     


Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn 
            580                 585                 590         


Gln Val Ala Val Leu Tyr Gln Gly Val Asn Cys Thr Glu Val Pro Val 
        595                 600                 605             


Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr 
    610                 615                 620                 


Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu 
625                 630                 635                 640 


His Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile 
                645                 650                 655     


Cys Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro Gly Ser Ala Ser Ser 
            660                 665                 670         


Val Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Val Glu 
        675                 680                 685             


Asn Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe 
    690                 695                 700                 


Thr Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr 
705                 710                 715                 720 


Ser Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser 
                725                 730                 735     


Asn Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala 
            740                 745                 750         


Leu Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe 
        755                 760                 765             


Ala Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly 
    770                 775                 780                 


Gly Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys 
785                 790                 795                 800 


Arg Ser Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp 
                805                 810                 815     


Ala Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala 
            820                 825                 830         


Arg Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro 
        835                 840                 845             


Pro Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu 
    850                 855                 860                 


Ala Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu 
865                 870                 875                 880 


Gln Ile Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly 
                885                 890                 895     


Val Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln 
            900                 905                 910         


Phe Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala 
        915                 920                 925             


Ser Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala 
    930                 935                 940                 


Leu Asn Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser 
945                 950                 955                 960 


Ser Val Leu Asn Asp Ile Leu Ser Arg Leu Asp Pro Pro Glu Ala Glu 
                965                 970                 975     


Val Gln Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser Leu Gln Thr 
            980                 985                 990         


Tyr Val Thr Gln Gln Leu Ile Arg  Ala Ala Glu Ile Arg  Ala Ser Ala 
        995                 1000                 1005             


Asn Leu  Ala Ala Thr Lys Met  Ser Glu Cys Val Leu  Gly Gln Ser 
    1010                 1015                 1020             


Lys Arg  Val Asp Phe Cys Gly  Lys Gly Tyr His Leu  Met Ser Phe 
    1025                 1030                 1035             


Pro Gln  Ser Ala Pro His Gly  Val Val Phe Leu His  Val Thr Tyr 
    1040                 1045                 1050             


Val Pro  Ala Gln Glu Lys Asn  Phe Thr Thr Ala Pro  Ala Ile Cys 
    1055                 1060                 1065             


His Asp  Gly Lys Ala His Phe  Pro Arg Glu Gly Val  Phe Val Ser 
    1070                 1075                 1080             


Asn Gly  Thr His Trp Phe Val  Thr Gln Arg Asn Phe  Tyr Glu Pro 
    1085                 1090                 1095             


Gln Ile  Ile Thr Thr Asp Asn  Thr Phe Val Ser Gly  Asn Cys Asp 
    1100                 1105                 1110             


Val Val  Ile Gly Ile Val Asn  Asn Thr Val Tyr Asp  Pro Leu Gln 
    1115                 1120                 1125             


Ser Glu  Leu Asp Ser Ile Lys  Glu Glu Leu Asp Lys  Ile His Lys 
    1130                 1135                 1140             


Asn Leu  Asp Ser Ile Lys Glu  Glu Leu Asp Lys Ile  His Lys Asn 
    1145                 1150                 1155             


Gly Ser  Gly Gly Ser Gly Asp  Ile Ile Lys Leu Leu  Asn Glu Gln 
    1160                 1165                 1170             


Val Asn  Lys Glu Met Gln Ser  Ser Asn Leu Tyr Met  Ser Met Ser 
    1175                 1180                 1185             


Ser Trp  Cys Tyr Thr His Ser  Leu Asp Gly Ala Gly  Leu Phe Leu 
    1190                 1195                 1200             


Phe Asp  His Ala Ala Glu Glu  Tyr Glu His Ala Lys  Lys Leu Ile 
    1205                 1210                 1215             


Ile Phe  Leu Asn Glu Asn Asn  Val Pro Val Gln Leu  Thr Ser Ile 
    1220                 1225                 1230             


Ser Ala  Pro Glu His Lys Phe  Glu Gly Leu Thr Gln  Ile Phe Gln 
    1235                 1240                 1245             


Lys Ala  Tyr Glu His Glu Gln  His Ile Ser Glu Ser  Ile Asn Asn 
    1250                 1255                 1260             


Ile Val  Asp His Ala Ile Lys  Ser Lys Asp His Ala  Thr Phe Asn 
    1265                 1270                 1275             


Phe Leu  Gln Trp Tyr Val Ala  Glu Gln His Glu Glu  Glu Val Leu 
    1280                 1285                 1290             


Phe Lys  Asp Ile Leu Asp Lys  Ile Glu Leu Ile Gly  Asn Glu Asn 
    1295                 1300                 1305             


His Gly  Leu Tyr Leu Ala Asp  Gln Tyr Val Lys Gly  Ile Ala Lys 
    1310                 1315                 1320             


Ser Arg  Lys Ser Gly Ser 
    1325                 


<210> 243
<211> 1329
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 243
Ser Ser Gln Cys Val Asn Phe Thr Thr Arg Thr Gln Leu Pro Pro Ala 
1               5                   10                  15      


Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe 
            20                  25                  30          


Arg Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe 
        35                  40                  45              


Ser Asn Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly 
    50                  55                  60                  


Thr Lys Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr 
65                  70                  75                  80  


Phe Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly 
                85                  90                  95      


Thr Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala 
            100                 105                 110         


Thr Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro 
        115                 120                 125             


Phe Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser 
    130                 135                 140                 


Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val 
145                 150                 155                 160 


Ser Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys 
                165                 170                 175     


Asn Leu Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile 
            180                 185                 190         


Tyr Ser Lys His Thr Pro Ile Asn Leu Val Arg Gly Leu Pro Gln Gly 
        195                 200                 205             


Phe Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile 
    210                 215                 220                 


Thr Arg Phe Gln Thr Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser 
225                 230                 235                 240 


Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu 
                245                 250                 255     


Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr 
            260                 265                 270         


Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr 
        275                 280                 285             


Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe 
    290                 295                 300                 


Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn 
305                 310                 315                 320 


Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val 
                325                 330                 335     


Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser 
            340                 345                 350         


Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val 
        355                 360                 365             


Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp 
    370                 375                 380                 


Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln 
385                 390                 395                 400 


Thr Gly Asn Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr 
                405                 410                 415     


Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly 
            420                 425                 430         


Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys 
        435                 440                 445             


Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr 
    450                 455                 460                 


Pro Cys Asn Gly Val Lys Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser 
465                 470                 475                 480 


Tyr Gly Phe Gln Pro Thr Tyr Gly Val Gly Tyr Gln Pro Tyr Arg Val 
                485                 490                 495     


Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly 
            500                 505                 510         


Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn 
        515                 520                 525             


Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys 
    530                 535                 540                 


Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp 
545                 550                 555                 560 


Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys 
                565                 570                 575     


Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn 
            580                 585                 590         


Gln Val Ala Val Leu Tyr Gln Gly Val Asn Cys Thr Glu Val Pro Val 
        595                 600                 605             


Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr 
    610                 615                 620                 


Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu 
625                 630                 635                 640 


His Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile 
                645                 650                 655     


Cys Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro Gly Ser Ala Ser Ser 
            660                 665                 670         


Val Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Val Glu 
        675                 680                 685             


Asn Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe 
    690                 695                 700                 


Thr Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr 
705                 710                 715                 720 


Ser Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser 
                725                 730                 735     


Asn Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala 
            740                 745                 750         


Leu Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe 
        755                 760                 765             


Ala Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly 
    770                 775                 780                 


Gly Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys 
785                 790                 795                 800 


Arg Ser Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp 
                805                 810                 815     


Ala Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala 
            820                 825                 830         


Arg Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro 
        835                 840                 845             


Pro Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu 
    850                 855                 860                 


Ala Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu 
865                 870                 875                 880 


Gln Ile Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly 
                885                 890                 895     


Val Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln 
            900                 905                 910         


Phe Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala 
        915                 920                 925             


Ser Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala 
    930                 935                 940                 


Leu Asn Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser 
945                 950                 955                 960 


Ser Val Leu Asn Asp Ile Leu Ser Arg Leu Asp Pro Pro Glu Ala Glu 
                965                 970                 975     


Val Gln Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser Leu Gln Thr 
            980                 985                 990         


Tyr Val Thr Gln Gln Leu Ile Arg  Ala Ala Glu Ile Arg  Ala Ser Ala 
        995                 1000                 1005             


Asn Leu  Ala Ala Thr Lys Met  Ser Glu Cys Val Leu  Gly Gln Ser 
    1010                 1015                 1020             


Lys Arg  Val Asp Phe Cys Gly  Lys Gly Tyr His Leu  Met Ser Phe 
    1025                 1030                 1035             


Pro Gln  Ser Ala Pro His Gly  Val Val Phe Leu His  Val Thr Tyr 
    1040                 1045                 1050             


Val Pro  Ala Gln Glu Lys Asn  Phe Thr Thr Ala Pro  Ala Ile Cys 
    1055                 1060                 1065             


His Asp  Gly Lys Ala His Phe  Pro Arg Glu Gly Val  Phe Val Ser 
    1070                 1075                 1080             


Asn Gly  Thr His Trp Phe Val  Thr Gln Arg Asn Phe  Tyr Glu Pro 
    1085                 1090                 1095             


Gln Ile  Ile Thr Thr Asp Asn  Thr Phe Val Ser Gly  Asn Cys Asp 
    1100                 1105                 1110             


Val Val  Ile Gly Ile Val Asn  Asn Thr Val Tyr Asp  Pro Leu Gln 
    1115                 1120                 1125             


Ser Glu  Leu Asp Ser Ile Lys  Glu Glu Leu Asp Lys  Ile His Lys 
    1130                 1135                 1140             


Asn Leu  Asp Ser Ile Lys Glu  Glu Leu Asp Lys Ile  His Lys Asn 
    1145                 1150                 1155             


Gly Ser  Gly Gly Ser Gly Asp  Ile Ile Lys Leu Leu  Asn Glu Gln 
    1160                 1165                 1170             


Val Asn  Lys Glu Met Gln Ser  Ser Asn Leu Tyr Met  Ser Met Ser 
    1175                 1180                 1185             


Ser Trp  Cys Tyr Thr His Ser  Leu Asp Gly Ala Gly  Leu Phe Leu 
    1190                 1195                 1200             


Phe Asp  His Ala Ala Glu Glu  Tyr Glu His Ala Lys  Lys Leu Ile 
    1205                 1210                 1215             


Ile Phe  Leu Asn Glu Asn Asn  Val Pro Val Gln Leu  Thr Ser Ile 
    1220                 1225                 1230             


Ser Ala  Pro Glu His Lys Phe  Glu Gly Leu Thr Gln  Ile Phe Gln 
    1235                 1240                 1245             


Lys Ala  Tyr Glu His Glu Gln  His Ile Ser Glu Ser  Ile Asn Asn 
    1250                 1255                 1260             


Ile Val  Asp His Ala Ile Lys  Ser Lys Asp His Ala  Thr Phe Asn 
    1265                 1270                 1275             


Phe Leu  Gln Trp Tyr Val Ala  Glu Gln His Glu Glu  Glu Val Leu 
    1280                 1285                 1290             


Phe Lys  Asp Ile Leu Asp Lys  Ile Glu Leu Ile Gly  Asn Glu Asn 
    1295                 1300                 1305             


His Gly  Leu Tyr Leu Ala Asp  Gln Tyr Val Lys Gly  Ile Ala Lys 
    1310                 1315                 1320             


Ser Arg  Lys Ser Gly Ser 
    1325                 


<210> 244
<211> 1329
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 244
Ser Ser Gln Cys Val Asn Phe Thr Thr Arg Thr Gln Leu Pro Pro Ala 
1               5                   10                  15      


Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe 
            20                  25                  30          


Arg Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe 
        35                  40                  45              


Ser Asn Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly 
    50                  55                  60                  


Thr Lys Arg Phe Ala Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr 
65                  70                  75                  80  


Phe Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly 
                85                  90                  95      


Thr Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala 
            100                 105                 110         


Thr Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro 
        115                 120                 125             


Phe Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser 
    130                 135                 140                 


Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val 
145                 150                 155                 160 


Ser Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys 
                165                 170                 175     


Asn Leu Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile 
            180                 185                 190         


Tyr Ser Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly 
        195                 200                 205             


Phe Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile 
    210                 215                 220                 


Thr Arg Phe Gln Thr Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser 
225                 230                 235                 240 


Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu 
                245                 250                 255     


Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr 
            260                 265                 270         


Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr 
        275                 280                 285             


Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe 
    290                 295                 300                 


Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn 
305                 310                 315                 320 


Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val 
                325                 330                 335     


Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser 
            340                 345                 350         


Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val 
        355                 360                 365             


Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp 
    370                 375                 380                 


Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln 
385                 390                 395                 400 


Thr Gly Asn Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr 
                405                 410                 415     


Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly 
            420                 425                 430         


Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys 
        435                 440                 445             


Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr 
    450                 455                 460                 


Pro Cys Asn Gly Val Lys Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser 
465                 470                 475                 480 


Tyr Gly Phe Gln Pro Thr Tyr Gly Val Gly Tyr Gln Pro Tyr Arg Val 
                485                 490                 495     


Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly 
            500                 505                 510         


Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn 
        515                 520                 525             


Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys 
    530                 535                 540                 


Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp 
545                 550                 555                 560 


Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys 
                565                 570                 575     


Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn 
            580                 585                 590         


Gln Val Ala Val Leu Tyr Gln Gly Val Asn Cys Thr Glu Val Pro Val 
        595                 600                 605             


Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr 
    610                 615                 620                 


Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu 
625                 630                 635                 640 


His Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile 
                645                 650                 655     


Cys Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro Gly Ser Ala Ser Ser 
            660                 665                 670         


Val Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Val Glu 
        675                 680                 685             


Asn Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe 
    690                 695                 700                 


Thr Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr 
705                 710                 715                 720 


Ser Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser 
                725                 730                 735     


Asn Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala 
            740                 745                 750         


Leu Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe 
        755                 760                 765             


Ala Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly 
    770                 775                 780                 


Gly Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys 
785                 790                 795                 800 


Arg Ser Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp 
                805                 810                 815     


Ala Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala 
            820                 825                 830         


Arg Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro 
        835                 840                 845             


Pro Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu 
    850                 855                 860                 


Ala Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu 
865                 870                 875                 880 


Gln Ile Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly 
                885                 890                 895     


Val Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln 
            900                 905                 910         


Phe Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala 
        915                 920                 925             


Ser Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala 
    930                 935                 940                 


Leu Asn Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser 
945                 950                 955                 960 


Ser Val Leu Asn Asp Ile Leu Ser Arg Leu Asp Pro Pro Glu Ala Glu 
                965                 970                 975     


Val Gln Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser Leu Gln Thr 
            980                 985                 990         


Tyr Val Thr Gln Gln Leu Ile Arg  Ala Ala Glu Ile Arg  Ala Ser Ala 
        995                 1000                 1005             


Asn Leu  Ala Ala Thr Lys Met  Ser Glu Cys Val Leu  Gly Gln Ser 
    1010                 1015                 1020             


Lys Arg  Val Asp Phe Cys Gly  Lys Gly Tyr His Leu  Met Ser Phe 
    1025                 1030                 1035             


Pro Gln  Ser Ala Pro His Gly  Val Val Phe Leu His  Val Thr Tyr 
    1040                 1045                 1050             


Val Pro  Ala Gln Glu Lys Asn  Phe Thr Thr Ala Pro  Ala Ile Cys 
    1055                 1060                 1065             


His Asp  Gly Lys Ala His Phe  Pro Arg Glu Gly Val  Phe Val Ser 
    1070                 1075                 1080             


Asn Gly  Thr His Trp Phe Val  Thr Gln Arg Asn Phe  Tyr Glu Pro 
    1085                 1090                 1095             


Gln Ile  Ile Thr Thr Asp Asn  Thr Phe Val Ser Gly  Asn Cys Asp 
    1100                 1105                 1110             


Val Val  Ile Gly Ile Val Asn  Asn Thr Val Tyr Asp  Pro Leu Gln 
    1115                 1120                 1125             


Ser Glu  Leu Asp Ser Ile Lys  Glu Glu Leu Asp Lys  Ile His Lys 
    1130                 1135                 1140             


Asn Leu  Asp Ser Ile Lys Glu  Glu Leu Asp Lys Ile  His Lys Asn 
    1145                 1150                 1155             


Gly Ser  Gly Gly Ser Gly Asp  Ile Ile Lys Leu Leu  Asn Glu Gln 
    1160                 1165                 1170             


Val Asn  Lys Glu Met Gln Ser  Ser Asn Leu Tyr Met  Ser Met Ser 
    1175                 1180                 1185             


Ser Trp  Cys Tyr Thr His Ser  Leu Asp Gly Ala Gly  Leu Phe Leu 
    1190                 1195                 1200             


Phe Asp  His Ala Ala Glu Glu  Tyr Glu His Ala Lys  Lys Leu Ile 
    1205                 1210                 1215             


Ile Phe  Leu Asn Glu Asn Asn  Val Pro Val Gln Leu  Thr Ser Ile 
    1220                 1225                 1230             


Ser Ala  Pro Glu His Lys Phe  Glu Gly Leu Thr Gln  Ile Phe Gln 
    1235                 1240                 1245             


Lys Ala  Tyr Glu His Glu Gln  His Ile Ser Glu Ser  Ile Asn Asn 
    1250                 1255                 1260             


Ile Val  Asp His Ala Ile Lys  Ser Lys Asp His Ala  Thr Phe Asn 
    1265                 1270                 1275             


Phe Leu  Gln Trp Tyr Val Ala  Glu Gln His Glu Glu  Glu Val Leu 
    1280                 1285                 1290             


Phe Lys  Asp Ile Leu Asp Lys  Ile Glu Leu Ile Gly  Asn Glu Asn 
    1295                 1300                 1305             


His Gly  Leu Tyr Leu Ala Asp  Gln Tyr Val Lys Gly  Ile Ala Lys 
    1310                 1315                 1320             


Ser Arg  Lys Ser Gly Ser 
    1325                 


<210> 245
<211> 1332
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 245
Ser Ser Gln Cys Val Asn Phe Thr Asn Arg Thr Gln Leu Pro Ser Ala 
1               5                   10                  15      


Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe 
            20                  25                  30          


Arg Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe 
        35                  40                  45              


Ser Asn Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly 
    50                  55                  60                  


Thr Lys Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr 
65                  70                  75                  80  


Phe Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly 
                85                  90                  95      


Thr Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala 
            100                 105                 110         


Thr Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Tyr Pro 
        115                 120                 125             


Phe Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser 
    130                 135                 140                 


Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val 
145                 150                 155                 160 


Ser Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys 
                165                 170                 175     


Asn Leu Ser Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile 
            180                 185                 190         


Tyr Ser Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly 
        195                 200                 205             


Phe Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile 
    210                 215                 220                 


Thr Arg Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro 
225                 230                 235                 240 


Gly Asp Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val 
                245                 250                 255     


Gly Tyr Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly 
            260                 265                 270         


Thr Ile Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr 
        275                 280                 285             


Lys Cys Thr Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr 
    290                 295                 300                 


Ser Asn Phe Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn 
305                 310                 315                 320 


Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe 
                325                 330                 335     


Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala 
            340                 345                 350         


Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys 
        355                 360                 365             


Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val 
    370                 375                 380                 


Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala 
385                 390                 395                 400 


Pro Gly Gln Thr Gly Thr Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp 
                405                 410                 415     


Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser 
            420                 425                 430         


Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser 
        435                 440                 445             


Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala 
    450                 455                 460                 


Gly Ser Thr Pro Cys Asn Gly Val Lys Gly Phe Asn Cys Tyr Phe Pro 
465                 470                 475                 480 


Leu Gln Ser Tyr Gly Phe Gln Pro Thr Tyr Gly Val Gly Tyr Gln Pro 
                485                 490                 495     


Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr 
            500                 505                 510         


Val Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val 
        515                 520                 525             


Asn Phe Asn Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser 
    530                 535                 540                 


Asn Lys Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp 
545                 550                 555                 560 


Thr Thr Asp Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile 
                565                 570                 575     


Thr Pro Cys Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn 
            580                 585                 590         


Thr Ser Asn Gln Val Ala Val Leu Tyr Gln Gly Val Asn Cys Thr Glu 
        595                 600                 605             


Val Pro Val Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val 
    610                 615                 620                 


Tyr Ser Thr Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile 
625                 630                 635                 640 


Gly Ala Glu Tyr Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly 
                645                 650                 655     


Ala Gly Ile Cys Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro Gly Ser 
            660                 665                 670         


Ala Ser Ser Val Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu 
        675                 680                 685             


Gly Ala Glu Asn Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro 
    690                 695                 700                 


Thr Asn Phe Thr Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met 
705                 710                 715                 720 


Thr Lys Thr Ser Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr 
                725                 730                 735     


Glu Cys Ser Asn Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu 
            740                 745                 750         


Asn Arg Ala Leu Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln 
        755                 760                 765             


Glu Val Phe Ala Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys 
    770                 775                 780                 


Asp Phe Gly Gly Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys 
785                 790                 795                 800 


Pro Ser Lys Arg Ser Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr 
                805                 810                 815     


Leu Ala Asp Ala Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp 
            820                 825                 830         


Ile Ala Ala Arg Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr 
        835                 840                 845             


Val Leu Pro Pro Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser 
    850                 855                 860                 


Ala Leu Leu Ala Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly 
865                 870                 875                 880 


Ala Ala Leu Gln Ile Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn 
                885                 890                 895     


Gly Ile Gly Val Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile 
            900                 905                 910         


Ala Asn Gln Phe Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser 
        915                 920                 925             


Ser Thr Ala Ser Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn 
    930                 935                 940                 


Ala Gln Ala Leu Asn Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly 
945                 950                 955                 960 


Ala Ile Ser Ser Val Leu Asn Asp Ile Leu Ser Arg Leu Asp Pro Pro 
                965                 970                 975     


Glu Ala Glu Val Gln Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser 
            980                 985                 990         


Leu Gln Thr Tyr Val Thr Gln Gln  Leu Ile Arg Ala Ala  Glu Ile Arg 
        995                 1000                 1005             


Ala Ser  Ala Asn Leu Ala Ala  Ile Lys Met Ser Glu  Cys Val Leu 
    1010                 1015                 1020             


Gly Gln  Ser Lys Arg Val Asp  Phe Cys Gly Lys Gly  Tyr His Leu 
    1025                 1030                 1035             


Met Ser  Phe Pro Gln Ser Ala  Pro His Gly Val Val  Phe Leu His 
    1040                 1045                 1050             


Val Thr  Tyr Val Pro Ala Gln  Glu Lys Asn Phe Thr  Thr Ala Pro 
    1055                 1060                 1065             


Ala Ile  Cys His Asp Gly Lys  Ala His Phe Pro Arg  Glu Gly Val 
    1070                 1075                 1080             


Phe Val  Ser Asn Gly Thr His  Trp Phe Val Thr Gln  Arg Asn Phe 
    1085                 1090                 1095             


Tyr Glu  Pro Gln Ile Ile Thr  Thr Asp Asn Thr Phe  Val Ser Gly 
    1100                 1105                 1110             


Asn Cys  Asp Val Val Ile Gly  Ile Val Asn Asn Thr  Val Tyr Asp 
    1115                 1120                 1125             


Pro Leu  Gln Ser Glu Leu Asp  Ser Ile Lys Glu Glu  Leu Asp Lys 
    1130                 1135                 1140             


Ile His  Lys Asn Leu Asp Ser  Ile Lys Glu Glu Leu  Asp Lys Ile 
    1145                 1150                 1155             


His Lys  Asn Gly Ser Gly Gly  Ser Gly Asp Ile Ile  Lys Leu Leu 
    1160                 1165                 1170             


Asn Glu  Gln Val Asn Lys Glu  Met Gln Ser Ser Asn  Leu Tyr Met 
    1175                 1180                 1185             


Ser Met  Ser Ser Trp Cys Tyr  Thr His Ser Leu Asp  Gly Ala Gly 
    1190                 1195                 1200             


Leu Phe  Leu Phe Asp His Ala  Ala Glu Glu Tyr Glu  His Ala Lys 
    1205                 1210                 1215             


Lys Leu  Ile Ile Phe Leu Asn  Glu Asn Asn Val Pro  Val Gln Leu 
    1220                 1225                 1230             


Thr Ser  Ile Ser Ala Pro Glu  His Lys Phe Glu Gly  Leu Thr Gln 
    1235                 1240                 1245             


Ile Phe  Gln Lys Ala Tyr Glu  His Glu Gln His Ile  Ser Glu Ser 
    1250                 1255                 1260             


Ile Asn  Asn Ile Val Asp His  Ala Ile Lys Ser Lys  Asp His Ala 
    1265                 1270                 1275             


Thr Phe  Asn Phe Leu Gln Trp  Tyr Val Ala Glu Gln  His Glu Glu 
    1280                 1285                 1290             


Glu Val  Leu Phe Lys Asp Ile  Leu Asp Lys Ile Glu  Leu Ile Gly 
    1295                 1300                 1305             


Asn Glu  Asn His Gly Leu Tyr  Leu Ala Asp Gln Tyr  Val Lys Gly 
    1310                 1315                 1320             


Ile Ala  Lys Ser Arg Lys Ser  Gly Ser 
    1325                 1330         


<210> 246
<211> 1315
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 246
Ser Ser Gln Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala 
1               5                   10                  15      


Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe 
            20                  25                  30          


Arg Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe 
        35                  40                  45              


Ser Asn Val Thr Trp Phe His Ala Ile Ser Gly Thr Asn Gly Thr Lys 
    50                  55                  60                  


Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala 
65                  70                  75                  80  


Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr 
                85                  90                  95      


Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn 
            100                 105                 110         


Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu 
        115                 120                 125             


Gly Val Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg 
    130                 135                 140                 


Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro 
145                 150                 155                 160 


Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg 
                165                 170                 175     


Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys 
            180                 185                 190         


His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala 
        195                 200                 205             


Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe 
    210                 215                 220                 


Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser 
225                 230                 235                 240 


Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu 
                245                 250                 255     


Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr 
            260                 265                 270         


Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr 
        275                 280                 285             


Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe 
    290                 295                 300                 


Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn 
305                 310                 315                 320 


Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val 
                325                 330                 335     


Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser 
            340                 345                 350         


Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val 
        355                 360                 365             


Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp 
    370                 375                 380                 


Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln 
385                 390                 395                 400 


Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr 
                405                 410                 415     


Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly 
            420                 425                 430         


Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys 
        435                 440                 445             


Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr 
    450                 455                 460                 


Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser 
465                 470                 475                 480 


Tyr Gly Phe Gln Pro Thr Tyr Gly Val Gly Tyr Gln Pro Tyr Arg Val 
                485                 490                 495     


Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly 
            500                 505                 510         


Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn 
        515                 520                 525             


Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys 
    530                 535                 540                 


Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Asp Asp Thr Thr Asp 
545                 550                 555                 560 


Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys 
                565                 570                 575     


Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn 
            580                 585                 590         


Gln Val Ala Val Leu Tyr Gln Gly Val Asn Cys Thr Glu Val Pro Val 
        595                 600                 605             


Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr 
    610                 615                 620                 


Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu 
625                 630                 635                 640 


His Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile 
                645                 650                 655     


Cys Ala Ser Tyr Gln Thr Gln Thr Asn Ser His Gly Ser Ala Ser Ser 
            660                 665                 670         


Val Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu 
        675                 680                 685             


Asn Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Ile Asn Phe 
    690                 695                 700                 


Thr Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr 
705                 710                 715                 720 


Ser Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser 
                725                 730                 735     


Asn Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala 
            740                 745                 750         


Leu Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe 
        755                 760                 765             


Ala Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly 
    770                 775                 780                 


Gly Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys 
785                 790                 795                 800 


Arg Ser Pro Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp 
                805                 810                 815     


Ala Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala 
            820                 825                 830         


Arg Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro 
        835                 840                 845             


Pro Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu 
    850                 855                 860                 


Ala Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Pro Ala Leu 
865                 870                 875                 880 


Gln Ile Pro Phe Pro Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly 
                885                 890                 895     


Val Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln 
            900                 905                 910         


Phe Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Pro 
        915                 920                 925             


Ser Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala 
    930                 935                 940                 


Leu Asn Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser 
945                 950                 955                 960 


Ser Val Leu Asn Asp Ile Leu Ala Arg Leu Asp Pro Pro Glu Ala Glu 
                965                 970                 975     


Val Gln Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser Leu Gln Thr 
            980                 985                 990         


Tyr Val Thr Gln Gln Leu Ile Arg  Ala Ala Glu Ile Arg  Ala Ser Ala 
        995                 1000                 1005             


Asn Leu  Ala Ala Thr Lys Met  Ser Glu Cys Val Leu  Gly Gln Ser 
    1010                 1015                 1020             


Lys Arg  Val Asp Phe Cys Gly  Lys Gly Tyr His Leu  Met Ser Phe 
    1025                 1030                 1035             


Pro Gln  Ser Ala Pro His Gly  Val Val Phe Leu His  Val Thr Tyr 
    1040                 1045                 1050             


Val Pro  Ala Gln Glu Lys Asn  Phe Thr Thr Ala Pro  Ala Ile Cys 
    1055                 1060                 1065             


His Asp  Gly Lys Ala His Phe  Pro Arg Glu Gly Val  Phe Val Ser 
    1070                 1075                 1080             


Asn Gly  Thr His Trp Phe Val  Thr Gln Arg Asn Phe  Tyr Glu Pro 
    1085                 1090                 1095             


Gln Ile  Ile Thr Thr His Asn  Thr Phe Val Ser Gly  Asn Cys Asp 
    1100                 1105                 1110             


Val Val  Ile Gly Ile Val Asn  Asn Thr Val Tyr Asp  Pro Leu Gln 
    1115                 1120                 1125             


Ser Glu  Leu Asp Ser Ile Lys  Glu Glu Leu Asp Lys  Ile His Lys 
    1130                 1135                 1140             


Asn Gly  Ser Gly Gly Ser Gly  Asp Ile Ile Lys Leu  Leu Asn Glu 
    1145                 1150                 1155             


Gln Val  Asn Lys Glu Met Gln  Ser Ser Asn Leu Tyr  Met Ser Met 
    1160                 1165                 1170             


Ser Ser  Trp Cys Tyr Thr His  Ser Leu Asp Gly Ala  Gly Leu Phe 
    1175                 1180                 1185             


Leu Phe  Asp His Ala Ala Glu  Glu Tyr Glu His Ala  Lys Lys Leu 
    1190                 1195                 1200             


Ile Ile  Phe Leu Asn Glu Asn  Asn Val Pro Val Gln  Leu Thr Ser 
    1205                 1210                 1215             


Ile Ser  Ala Pro Glu His Lys  Phe Glu Gly Leu Thr  Gln Ile Phe 
    1220                 1225                 1230             


Gln Lys  Ala Tyr Glu His Glu  Gln His Ile Ser Glu  Ser Ile Asn 
    1235                 1240                 1245             


Asn Ile  Val Asp His Ala Ile  Lys Ser Lys Asp His  Ala Thr Phe 
    1250                 1255                 1260             


Asn Phe  Leu Gln Trp Tyr Val  Ala Glu Gln His Glu  Glu Glu Val 
    1265                 1270                 1275             


Leu Phe  Lys Asp Ile Leu Asp  Lys Ile Glu Leu Ile  Gly Asn Glu 
    1280                 1285                 1290             


Asn His  Gly Leu Tyr Leu Ala  Asp Gln Tyr Val Lys  Gly Ile Ala 
    1295                 1300                 1305             


Lys Ser  Arg Lys Ser Gly Ser  
    1310                 1315 


<210> 247
<211> 1315
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 247
Ser Ser Gln Cys Val Asn Phe Thr Thr Arg Thr Gln Leu Pro Pro Ala 
1               5                   10                  15      


Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe 
            20                  25                  30          


Arg Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe 
        35                  40                  45              


Ser Asn Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly 
    50                  55                  60                  


Thr Lys Arg Phe Ala Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr 
65                  70                  75                  80  


Phe Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly 
                85                  90                  95      


Thr Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala 
            100                 105                 110         


Thr Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro 
        115                 120                 125             


Phe Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser 
    130                 135                 140                 


Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val 
145                 150                 155                 160 


Ser Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys 
                165                 170                 175     


Asn Leu Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile 
            180                 185                 190         


Tyr Ser Lys His Thr Pro Ile Asn Leu Val Arg Gly Leu Pro Gln Gly 
        195                 200                 205             


Phe Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile 
    210                 215                 220                 


Thr Arg Phe Gln Thr Leu His Ile Ser Tyr Leu Thr Pro Gly Asp Ser 
225                 230                 235                 240 


Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu 
                245                 250                 255     


Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr 
            260                 265                 270         


Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr 
        275                 280                 285             


Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe 
    290                 295                 300                 


Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn 
305                 310                 315                 320 


Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val 
                325                 330                 335     


Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser 
            340                 345                 350         


Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val 
        355                 360                 365             


Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp 
    370                 375                 380                 


Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln 
385                 390                 395                 400 


Thr Gly Asn Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr 
                405                 410                 415     


Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly 
            420                 425                 430         


Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys 
        435                 440                 445             


Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr 
    450                 455                 460                 


Pro Cys Asn Gly Val Lys Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser 
465                 470                 475                 480 


Tyr Gly Phe Gln Pro Thr Tyr Gly Val Gly Tyr Gln Pro Tyr Arg Val 
                485                 490                 495     


Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly 
            500                 505                 510         


Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn 
        515                 520                 525             


Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys 
    530                 535                 540                 


Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp 
545                 550                 555                 560 


Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys 
                565                 570                 575     


Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn 
            580                 585                 590         


Gln Val Ala Val Leu Tyr Gln Gly Val Asn Cys Thr Glu Val Pro Val 
        595                 600                 605             


Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr 
    610                 615                 620                 


Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu 
625                 630                 635                 640 


His Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile 
                645                 650                 655     


Cys Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro Gly Ser Ala Ser Ser 
            660                 665                 670         


Val Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Val Glu 
        675                 680                 685             


Asn Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe 
    690                 695                 700                 


Thr Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr 
705                 710                 715                 720 


Ser Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser 
                725                 730                 735     


Asn Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala 
            740                 745                 750         


Leu Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe 
        755                 760                 765             


Ala Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly 
    770                 775                 780                 


Gly Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys 
785                 790                 795                 800 


Arg Ser Pro Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp 
                805                 810                 815     


Ala Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala 
            820                 825                 830         


Arg Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro 
        835                 840                 845             


Pro Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu 
    850                 855                 860                 


Ala Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Pro Ala Leu 
865                 870                 875                 880 


Gln Ile Pro Phe Pro Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly 
                885                 890                 895     


Val Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln 
            900                 905                 910         


Phe Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Pro 
        915                 920                 925             


Ser Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala 
    930                 935                 940                 


Leu Asn Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser 
945                 950                 955                 960 


Ser Val Leu Asn Asp Ile Leu Ser Arg Leu Asp Pro Pro Glu Ala Glu 
                965                 970                 975     


Val Gln Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser Leu Gln Thr 
            980                 985                 990         


Tyr Val Thr Gln Gln Leu Ile Arg  Ala Ala Glu Ile Arg  Ala Ser Ala 
        995                 1000                 1005             


Asn Leu  Ala Ala Thr Lys Met  Ser Glu Cys Val Leu  Gly Gln Ser 
    1010                 1015                 1020             


Lys Arg  Val Asp Phe Cys Gly  Lys Gly Tyr His Leu  Met Ser Phe 
    1025                 1030                 1035             


Pro Gln  Ser Ala Pro His Gly  Val Val Phe Leu His  Val Thr Tyr 
    1040                 1045                 1050             


Val Pro  Ala Gln Glu Lys Asn  Phe Thr Thr Ala Pro  Ala Ile Cys 
    1055                 1060                 1065             


His Asp  Gly Lys Ala His Phe  Pro Arg Glu Gly Val  Phe Val Ser 
    1070                 1075                 1080             


Asn Gly  Thr His Trp Phe Val  Thr Gln Arg Asn Phe  Tyr Glu Pro 
    1085                 1090                 1095             


Gln Ile  Ile Thr Thr Asp Asn  Thr Phe Val Ser Gly  Asn Cys Asp 
    1100                 1105                 1110             


Val Val  Ile Gly Ile Val Asn  Asn Thr Val Tyr Asp  Pro Leu Gln 
    1115                 1120                 1125             


Ser Glu  Leu Asp Ser Ile Lys  Glu Glu Leu Asp Lys  Ile His Lys 
    1130                 1135                 1140             


Asn Gly  Ser Gly Gly Ser Gly  Asp Ile Ile Lys Leu  Leu Asn Glu 
    1145                 1150                 1155             


Gln Val  Asn Lys Glu Met Gln  Ser Ser Asn Leu Tyr  Met Ser Met 
    1160                 1165                 1170             


Ser Ser  Trp Cys Tyr Thr His  Ser Leu Asp Gly Ala  Gly Leu Phe 
    1175                 1180                 1185             


Leu Phe  Asp His Ala Ala Glu  Glu Tyr Glu His Ala  Lys Lys Leu 
    1190                 1195                 1200             


Ile Ile  Phe Leu Asn Glu Asn  Asn Val Pro Val Gln  Leu Thr Ser 
    1205                 1210                 1215             


Ile Ser  Ala Pro Glu His Lys  Phe Glu Gly Leu Thr  Gln Ile Phe 
    1220                 1225                 1230             


Gln Lys  Ala Tyr Glu His Glu  Gln His Ile Ser Glu  Ser Ile Asn 
    1235                 1240                 1245             


Asn Ile  Val Asp His Ala Ile  Lys Ser Lys Asp His  Ala Thr Phe 
    1250                 1255                 1260             


Asn Phe  Leu Gln Trp Tyr Val  Ala Glu Gln His Glu  Glu Glu Val 
    1265                 1270                 1275             


Leu Phe  Lys Asp Ile Leu Asp  Lys Ile Glu Leu Ile  Gly Asn Glu 
    1280                 1285                 1290             


Asn His  Gly Leu Tyr Leu Ala  Asp Gln Tyr Val Lys  Gly Ile Ala 
    1295                 1300                 1305             


Lys Ser  Arg Lys Ser Gly Ser  
    1310                 1315 


<210> 248
<211> 1315
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 248
Ser Ser Gln Cys Val Asn Phe Thr Thr Arg Thr Gln Leu Pro Pro Ala 
1               5                   10                  15      


Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe 
            20                  25                  30          


Arg Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe 
        35                  40                  45              


Ser Asn Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly 
    50                  55                  60                  


Thr Lys Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr 
65                  70                  75                  80  


Phe Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly 
                85                  90                  95      


Thr Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala 
            100                 105                 110         


Thr Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro 
        115                 120                 125             


Phe Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser 
    130                 135                 140                 


Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val 
145                 150                 155                 160 


Ser Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys 
                165                 170                 175     


Asn Leu Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile 
            180                 185                 190         


Tyr Ser Lys His Thr Pro Ile Asn Leu Val Arg Gly Leu Pro Gln Gly 
        195                 200                 205             


Phe Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile 
    210                 215                 220                 


Thr Arg Phe Gln Thr Leu His Ile Ser Tyr Leu Thr Pro Gly Asp Ser 
225                 230                 235                 240 


Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu 
                245                 250                 255     


Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr 
            260                 265                 270         


Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr 
        275                 280                 285             


Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe 
    290                 295                 300                 


Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn 
305                 310                 315                 320 


Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val 
                325                 330                 335     


Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser 
            340                 345                 350         


Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val 
        355                 360                 365             


Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp 
    370                 375                 380                 


Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln 
385                 390                 395                 400 


Thr Gly Asn Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr 
                405                 410                 415     


Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly 
            420                 425                 430         


Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys 
        435                 440                 445             


Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr 
    450                 455                 460                 


Pro Cys Asn Gly Val Lys Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser 
465                 470                 475                 480 


Tyr Gly Phe Gln Pro Thr Tyr Gly Val Gly Tyr Gln Pro Tyr Arg Val 
                485                 490                 495     


Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly 
            500                 505                 510         


Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn 
        515                 520                 525             


Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys 
    530                 535                 540                 


Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp 
545                 550                 555                 560 


Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys 
                565                 570                 575     


Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn 
            580                 585                 590         


Gln Val Ala Val Leu Tyr Gln Gly Val Asn Cys Thr Glu Val Pro Val 
        595                 600                 605             


Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr 
    610                 615                 620                 


Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu 
625                 630                 635                 640 


His Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile 
                645                 650                 655     


Cys Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro Gly Ser Ala Ser Ser 
            660                 665                 670         


Val Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Val Glu 
        675                 680                 685             


Asn Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe 
    690                 695                 700                 


Thr Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr 
705                 710                 715                 720 


Ser Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser 
                725                 730                 735     


Asn Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala 
            740                 745                 750         


Leu Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe 
        755                 760                 765             


Ala Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly 
    770                 775                 780                 


Gly Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys 
785                 790                 795                 800 


Arg Ser Pro Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp 
                805                 810                 815     


Ala Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala 
            820                 825                 830         


Arg Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro 
        835                 840                 845             


Pro Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu 
    850                 855                 860                 


Ala Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Pro Ala Leu 
865                 870                 875                 880 


Gln Ile Pro Phe Pro Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly 
                885                 890                 895     


Val Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln 
            900                 905                 910         


Phe Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Pro 
        915                 920                 925             


Ser Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala 
    930                 935                 940                 


Leu Asn Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser 
945                 950                 955                 960 


Ser Val Leu Asn Asp Ile Leu Ser Arg Leu Asp Pro Pro Glu Ala Glu 
                965                 970                 975     


Val Gln Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser Leu Gln Thr 
            980                 985                 990         


Tyr Val Thr Gln Gln Leu Ile Arg  Ala Ala Glu Ile Arg  Ala Ser Ala 
        995                 1000                 1005             


Asn Leu  Ala Ala Thr Lys Met  Ser Glu Cys Val Leu  Gly Gln Ser 
    1010                 1015                 1020             


Lys Arg  Val Asp Phe Cys Gly  Lys Gly Tyr His Leu  Met Ser Phe 
    1025                 1030                 1035             


Pro Gln  Ser Ala Pro His Gly  Val Val Phe Leu His  Val Thr Tyr 
    1040                 1045                 1050             


Val Pro  Ala Gln Glu Lys Asn  Phe Thr Thr Ala Pro  Ala Ile Cys 
    1055                 1060                 1065             


His Asp  Gly Lys Ala His Phe  Pro Arg Glu Gly Val  Phe Val Ser 
    1070                 1075                 1080             


Asn Gly  Thr His Trp Phe Val  Thr Gln Arg Asn Phe  Tyr Glu Pro 
    1085                 1090                 1095             


Gln Ile  Ile Thr Thr Asp Asn  Thr Phe Val Ser Gly  Asn Cys Asp 
    1100                 1105                 1110             


Val Val  Ile Gly Ile Val Asn  Asn Thr Val Tyr Asp  Pro Leu Gln 
    1115                 1120                 1125             


Ser Glu  Leu Asp Ser Ile Lys  Glu Glu Leu Asp Lys  Ile His Lys 
    1130                 1135                 1140             


Asn Gly  Ser Gly Gly Ser Gly  Asp Ile Ile Lys Leu  Leu Asn Glu 
    1145                 1150                 1155             


Gln Val  Asn Lys Glu Met Gln  Ser Ser Asn Leu Tyr  Met Ser Met 
    1160                 1165                 1170             


Ser Ser  Trp Cys Tyr Thr His  Ser Leu Asp Gly Ala  Gly Leu Phe 
    1175                 1180                 1185             


Leu Phe  Asp His Ala Ala Glu  Glu Tyr Glu His Ala  Lys Lys Leu 
    1190                 1195                 1200             


Ile Ile  Phe Leu Asn Glu Asn  Asn Val Pro Val Gln  Leu Thr Ser 
    1205                 1210                 1215             


Ile Ser  Ala Pro Glu His Lys  Phe Glu Gly Leu Thr  Gln Ile Phe 
    1220                 1225                 1230             


Gln Lys  Ala Tyr Glu His Glu  Gln His Ile Ser Glu  Ser Ile Asn 
    1235                 1240                 1245             


Asn Ile  Val Asp His Ala Ile  Lys Ser Lys Asp His  Ala Thr Phe 
    1250                 1255                 1260             


Asn Phe  Leu Gln Trp Tyr Val  Ala Glu Gln His Glu  Glu Glu Val 
    1265                 1270                 1275             


Leu Phe  Lys Asp Ile Leu Asp  Lys Ile Glu Leu Ile  Gly Asn Glu 
    1280                 1285                 1290             


Asn His  Gly Leu Tyr Leu Ala  Asp Gln Tyr Val Lys  Gly Ile Ala 
    1295                 1300                 1305             


Lys Ser  Arg Lys Ser Gly Ser  
    1310                 1315 


<210> 249
<211> 1315
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 249
Ser Ser Gln Cys Val Asn Phe Thr Thr Arg Thr Gln Leu Pro Pro Ala 
1               5                   10                  15      


Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe 
            20                  25                  30          


Arg Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe 
        35                  40                  45              


Ser Asn Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly 
    50                  55                  60                  


Thr Lys Arg Phe Ala Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr 
65                  70                  75                  80  


Phe Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly 
                85                  90                  95      


Thr Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala 
            100                 105                 110         


Thr Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro 
        115                 120                 125             


Phe Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser 
    130                 135                 140                 


Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val 
145                 150                 155                 160 


Ser Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys 
                165                 170                 175     


Asn Leu Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile 
            180                 185                 190         


Tyr Ser Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly 
        195                 200                 205             


Phe Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile 
    210                 215                 220                 


Thr Arg Phe Gln Thr Leu His Ile Ser Tyr Leu Thr Pro Gly Asp Ser 
225                 230                 235                 240 


Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu 
                245                 250                 255     


Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr 
            260                 265                 270         


Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr 
        275                 280                 285             


Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe 
    290                 295                 300                 


Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn 
305                 310                 315                 320 


Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val 
                325                 330                 335     


Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser 
            340                 345                 350         


Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val 
        355                 360                 365             


Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp 
    370                 375                 380                 


Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln 
385                 390                 395                 400 


Thr Gly Asn Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr 
                405                 410                 415     


Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly 
            420                 425                 430         


Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys 
        435                 440                 445             


Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr 
    450                 455                 460                 


Pro Cys Asn Gly Val Lys Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser 
465                 470                 475                 480 


Tyr Gly Phe Gln Pro Thr Tyr Gly Val Gly Tyr Gln Pro Tyr Arg Val 
                485                 490                 495     


Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly 
            500                 505                 510         


Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn 
        515                 520                 525             


Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys 
    530                 535                 540                 


Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp 
545                 550                 555                 560 


Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys 
                565                 570                 575     


Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn 
            580                 585                 590         


Gln Val Ala Val Leu Tyr Gln Gly Val Asn Cys Thr Glu Val Pro Val 
        595                 600                 605             


Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr 
    610                 615                 620                 


Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu 
625                 630                 635                 640 


His Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile 
                645                 650                 655     


Cys Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro Gly Ser Ala Ser Ser 
            660                 665                 670         


Val Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Val Glu 
        675                 680                 685             


Asn Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe 
    690                 695                 700                 


Thr Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr 
705                 710                 715                 720 


Ser Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser 
                725                 730                 735     


Asn Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala 
            740                 745                 750         


Leu Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe 
        755                 760                 765             


Ala Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly 
    770                 775                 780                 


Gly Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys 
785                 790                 795                 800 


Arg Ser Pro Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp 
                805                 810                 815     


Ala Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala 
            820                 825                 830         


Arg Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro 
        835                 840                 845             


Pro Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu 
    850                 855                 860                 


Ala Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Pro Ala Leu 
865                 870                 875                 880 


Gln Ile Pro Phe Pro Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly 
                885                 890                 895     


Val Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln 
            900                 905                 910         


Phe Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Pro 
        915                 920                 925             


Ser Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala 
    930                 935                 940                 


Leu Asn Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser 
945                 950                 955                 960 


Ser Val Leu Asn Asp Ile Leu Ser Arg Leu Asp Pro Pro Glu Ala Glu 
                965                 970                 975     


Val Gln Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser Leu Gln Thr 
            980                 985                 990         


Tyr Val Thr Gln Gln Leu Ile Arg  Ala Ala Glu Ile Arg  Ala Ser Ala 
        995                 1000                 1005             


Asn Leu  Ala Ala Thr Lys Met  Ser Glu Cys Val Leu  Gly Gln Ser 
    1010                 1015                 1020             


Lys Arg  Val Asp Phe Cys Gly  Lys Gly Tyr His Leu  Met Ser Phe 
    1025                 1030                 1035             


Pro Gln  Ser Ala Pro His Gly  Val Val Phe Leu His  Val Thr Tyr 
    1040                 1045                 1050             


Val Pro  Ala Gln Glu Lys Asn  Phe Thr Thr Ala Pro  Ala Ile Cys 
    1055                 1060                 1065             


His Asp  Gly Lys Ala His Phe  Pro Arg Glu Gly Val  Phe Val Ser 
    1070                 1075                 1080             


Asn Gly  Thr His Trp Phe Val  Thr Gln Arg Asn Phe  Tyr Glu Pro 
    1085                 1090                 1095             


Gln Ile  Ile Thr Thr Asp Asn  Thr Phe Val Ser Gly  Asn Cys Asp 
    1100                 1105                 1110             


Val Val  Ile Gly Ile Val Asn  Asn Thr Val Tyr Asp  Pro Leu Gln 
    1115                 1120                 1125             


Ser Glu  Leu Asp Ser Ile Lys  Glu Glu Leu Asp Lys  Ile His Lys 
    1130                 1135                 1140             


Asn Gly  Ser Gly Gly Ser Gly  Asp Ile Ile Lys Leu  Leu Asn Glu 
    1145                 1150                 1155             


Gln Val  Asn Lys Glu Met Gln  Ser Ser Asn Leu Tyr  Met Ser Met 
    1160                 1165                 1170             


Ser Ser  Trp Cys Tyr Thr His  Ser Leu Asp Gly Ala  Gly Leu Phe 
    1175                 1180                 1185             


Leu Phe  Asp His Ala Ala Glu  Glu Tyr Glu His Ala  Lys Lys Leu 
    1190                 1195                 1200             


Ile Ile  Phe Leu Asn Glu Asn  Asn Val Pro Val Gln  Leu Thr Ser 
    1205                 1210                 1215             


Ile Ser  Ala Pro Glu His Lys  Phe Glu Gly Leu Thr  Gln Ile Phe 
    1220                 1225                 1230             


Gln Lys  Ala Tyr Glu His Glu  Gln His Ile Ser Glu  Ser Ile Asn 
    1235                 1240                 1245             


Asn Ile  Val Asp His Ala Ile  Lys Ser Lys Asp His  Ala Thr Phe 
    1250                 1255                 1260             


Asn Phe  Leu Gln Trp Tyr Val  Ala Glu Gln His Glu  Glu Glu Val 
    1265                 1270                 1275             


Leu Phe  Lys Asp Ile Leu Asp  Lys Ile Glu Leu Ile  Gly Asn Glu 
    1280                 1285                 1290             


Asn His  Gly Leu Tyr Leu Ala  Asp Gln Tyr Val Lys  Gly Ile Ala 
    1295                 1300                 1305             


Lys Ser  Arg Lys Ser Gly Ser  
    1310                 1315 


<210> 250
<211> 1315
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 250
Ser Ser Gln Cys Val Asn Phe Thr Thr Arg Thr Gln Leu Pro Pro Ala 
1               5                   10                  15      


Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe 
            20                  25                  30          


Arg Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe 
        35                  40                  45              


Ser Asn Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly 
    50                  55                  60                  


Thr Lys Arg Phe Ala Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr 
65                  70                  75                  80  


Phe Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly 
                85                  90                  95      


Thr Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala 
            100                 105                 110         


Thr Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro 
        115                 120                 125             


Phe Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser 
    130                 135                 140                 


Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val 
145                 150                 155                 160 


Ser Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys 
                165                 170                 175     


Asn Leu Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile 
            180                 185                 190         


Tyr Ser Lys His Thr Pro Ile Asn Leu Val Arg Gly Leu Pro Gln Gly 
        195                 200                 205             


Phe Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile 
    210                 215                 220                 


Thr Arg Phe Gln Thr Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser 
225                 230                 235                 240 


Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu 
                245                 250                 255     


Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr 
            260                 265                 270         


Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr 
        275                 280                 285             


Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe 
    290                 295                 300                 


Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn 
305                 310                 315                 320 


Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val 
                325                 330                 335     


Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser 
            340                 345                 350         


Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val 
        355                 360                 365             


Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp 
    370                 375                 380                 


Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln 
385                 390                 395                 400 


Thr Gly Asn Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr 
                405                 410                 415     


Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly 
            420                 425                 430         


Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys 
        435                 440                 445             


Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr 
    450                 455                 460                 


Pro Cys Asn Gly Val Lys Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser 
465                 470                 475                 480 


Tyr Gly Phe Gln Pro Thr Tyr Gly Val Gly Tyr Gln Pro Tyr Arg Val 
                485                 490                 495     


Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly 
            500                 505                 510         


Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn 
        515                 520                 525             


Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys 
    530                 535                 540                 


Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp 
545                 550                 555                 560 


Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys 
                565                 570                 575     


Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn 
            580                 585                 590         


Gln Val Ala Val Leu Tyr Gln Gly Val Asn Cys Thr Glu Val Pro Val 
        595                 600                 605             


Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr 
    610                 615                 620                 


Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu 
625                 630                 635                 640 


His Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile 
                645                 650                 655     


Cys Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro Gly Ser Ala Ser Ser 
            660                 665                 670         


Val Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Val Glu 
        675                 680                 685             


Asn Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe 
    690                 695                 700                 


Thr Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr 
705                 710                 715                 720 


Ser Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser 
                725                 730                 735     


Asn Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala 
            740                 745                 750         


Leu Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe 
        755                 760                 765             


Ala Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly 
    770                 775                 780                 


Gly Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys 
785                 790                 795                 800 


Arg Ser Pro Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp 
                805                 810                 815     


Ala Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala 
            820                 825                 830         


Arg Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro 
        835                 840                 845             


Pro Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu 
    850                 855                 860                 


Ala Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Pro Ala Leu 
865                 870                 875                 880 


Gln Ile Pro Phe Pro Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly 
                885                 890                 895     


Val Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln 
            900                 905                 910         


Phe Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Pro 
        915                 920                 925             


Ser Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala 
    930                 935                 940                 


Leu Asn Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser 
945                 950                 955                 960 


Ser Val Leu Asn Asp Ile Leu Ser Arg Leu Asp Pro Pro Glu Ala Glu 
                965                 970                 975     


Val Gln Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser Leu Gln Thr 
            980                 985                 990         


Tyr Val Thr Gln Gln Leu Ile Arg  Ala Ala Glu Ile Arg  Ala Ser Ala 
        995                 1000                 1005             


Asn Leu  Ala Ala Thr Lys Met  Ser Glu Cys Val Leu  Gly Gln Ser 
    1010                 1015                 1020             


Lys Arg  Val Asp Phe Cys Gly  Lys Gly Tyr His Leu  Met Ser Phe 
    1025                 1030                 1035             


Pro Gln  Ser Ala Pro His Gly  Val Val Phe Leu His  Val Thr Tyr 
    1040                 1045                 1050             


Val Pro  Ala Gln Glu Lys Asn  Phe Thr Thr Ala Pro  Ala Ile Cys 
    1055                 1060                 1065             


His Asp  Gly Lys Ala His Phe  Pro Arg Glu Gly Val  Phe Val Ser 
    1070                 1075                 1080             


Asn Gly  Thr His Trp Phe Val  Thr Gln Arg Asn Phe  Tyr Glu Pro 
    1085                 1090                 1095             


Gln Ile  Ile Thr Thr Asp Asn  Thr Phe Val Ser Gly  Asn Cys Asp 
    1100                 1105                 1110             


Val Val  Ile Gly Ile Val Asn  Asn Thr Val Tyr Asp  Pro Leu Gln 
    1115                 1120                 1125             


Ser Glu  Leu Asp Ser Ile Lys  Glu Glu Leu Asp Lys  Ile His Lys 
    1130                 1135                 1140             


Asn Gly  Ser Gly Gly Ser Gly  Asp Ile Ile Lys Leu  Leu Asn Glu 
    1145                 1150                 1155             


Gln Val  Asn Lys Glu Met Gln  Ser Ser Asn Leu Tyr  Met Ser Met 
    1160                 1165                 1170             


Ser Ser  Trp Cys Tyr Thr His  Ser Leu Asp Gly Ala  Gly Leu Phe 
    1175                 1180                 1185             


Leu Phe  Asp His Ala Ala Glu  Glu Tyr Glu His Ala  Lys Lys Leu 
    1190                 1195                 1200             


Ile Ile  Phe Leu Asn Glu Asn  Asn Val Pro Val Gln  Leu Thr Ser 
    1205                 1210                 1215             


Ile Ser  Ala Pro Glu His Lys  Phe Glu Gly Leu Thr  Gln Ile Phe 
    1220                 1225                 1230             


Gln Lys  Ala Tyr Glu His Glu  Gln His Ile Ser Glu  Ser Ile Asn 
    1235                 1240                 1245             


Asn Ile  Val Asp His Ala Ile  Lys Ser Lys Asp His  Ala Thr Phe 
    1250                 1255                 1260             


Asn Phe  Leu Gln Trp Tyr Val  Ala Glu Gln His Glu  Glu Glu Val 
    1265                 1270                 1275             


Leu Phe  Lys Asp Ile Leu Asp  Lys Ile Glu Leu Ile  Gly Asn Glu 
    1280                 1285                 1290             


Asn His  Gly Leu Tyr Leu Ala  Asp Gln Tyr Val Lys  Gly Ile Ala 
    1295                 1300                 1305             


Lys Ser  Arg Lys Ser Gly Ser  
    1310                 1315 


<210> 251
<211> 1315
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 251
Ser Ser Gln Cys Val Asn Phe Thr Thr Arg Thr Gln Leu Pro Pro Ala 
1               5                   10                  15      


Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe 
            20                  25                  30          


Arg Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe 
        35                  40                  45              


Ser Asn Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly 
    50                  55                  60                  


Thr Lys Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr 
65                  70                  75                  80  


Phe Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly 
                85                  90                  95      


Thr Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala 
            100                 105                 110         


Thr Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro 
        115                 120                 125             


Phe Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser 
    130                 135                 140                 


Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val 
145                 150                 155                 160 


Ser Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys 
                165                 170                 175     


Asn Leu Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile 
            180                 185                 190         


Tyr Ser Lys His Thr Pro Ile Asn Leu Val Arg Gly Leu Pro Gln Gly 
        195                 200                 205             


Phe Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile 
    210                 215                 220                 


Thr Arg Phe Gln Thr Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser 
225                 230                 235                 240 


Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu 
                245                 250                 255     


Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr 
            260                 265                 270         


Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr 
        275                 280                 285             


Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe 
    290                 295                 300                 


Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn 
305                 310                 315                 320 


Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val 
                325                 330                 335     


Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser 
            340                 345                 350         


Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val 
        355                 360                 365             


Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp 
    370                 375                 380                 


Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln 
385                 390                 395                 400 


Thr Gly Asn Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr 
                405                 410                 415     


Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly 
            420                 425                 430         


Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys 
        435                 440                 445             


Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr 
    450                 455                 460                 


Pro Cys Asn Gly Val Lys Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser 
465                 470                 475                 480 


Tyr Gly Phe Gln Pro Thr Tyr Gly Val Gly Tyr Gln Pro Tyr Arg Val 
                485                 490                 495     


Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly 
            500                 505                 510         


Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn 
        515                 520                 525             


Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys 
    530                 535                 540                 


Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp 
545                 550                 555                 560 


Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys 
                565                 570                 575     


Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn 
            580                 585                 590         


Gln Val Ala Val Leu Tyr Gln Gly Val Asn Cys Thr Glu Val Pro Val 
        595                 600                 605             


Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr 
    610                 615                 620                 


Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu 
625                 630                 635                 640 


His Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile 
                645                 650                 655     


Cys Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro Gly Ser Ala Ser Ser 
            660                 665                 670         


Val Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Val Glu 
        675                 680                 685             


Asn Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe 
    690                 695                 700                 


Thr Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr 
705                 710                 715                 720 


Ser Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser 
                725                 730                 735     


Asn Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala 
            740                 745                 750         


Leu Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe 
        755                 760                 765             


Ala Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly 
    770                 775                 780                 


Gly Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys 
785                 790                 795                 800 


Arg Ser Pro Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp 
                805                 810                 815     


Ala Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala 
            820                 825                 830         


Arg Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro 
        835                 840                 845             


Pro Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu 
    850                 855                 860                 


Ala Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Pro Ala Leu 
865                 870                 875                 880 


Gln Ile Pro Phe Pro Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly 
                885                 890                 895     


Val Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln 
            900                 905                 910         


Phe Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Pro 
        915                 920                 925             


Ser Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala 
    930                 935                 940                 


Leu Asn Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser 
945                 950                 955                 960 


Ser Val Leu Asn Asp Ile Leu Ser Arg Leu Asp Pro Pro Glu Ala Glu 
                965                 970                 975     


Val Gln Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser Leu Gln Thr 
            980                 985                 990         


Tyr Val Thr Gln Gln Leu Ile Arg  Ala Ala Glu Ile Arg  Ala Ser Ala 
        995                 1000                 1005             


Asn Leu  Ala Ala Thr Lys Met  Ser Glu Cys Val Leu  Gly Gln Ser 
    1010                 1015                 1020             


Lys Arg  Val Asp Phe Cys Gly  Lys Gly Tyr His Leu  Met Ser Phe 
    1025                 1030                 1035             


Pro Gln  Ser Ala Pro His Gly  Val Val Phe Leu His  Val Thr Tyr 
    1040                 1045                 1050             


Val Pro  Ala Gln Glu Lys Asn  Phe Thr Thr Ala Pro  Ala Ile Cys 
    1055                 1060                 1065             


His Asp  Gly Lys Ala His Phe  Pro Arg Glu Gly Val  Phe Val Ser 
    1070                 1075                 1080             


Asn Gly  Thr His Trp Phe Val  Thr Gln Arg Asn Phe  Tyr Glu Pro 
    1085                 1090                 1095             


Gln Ile  Ile Thr Thr Asp Asn  Thr Phe Val Ser Gly  Asn Cys Asp 
    1100                 1105                 1110             


Val Val  Ile Gly Ile Val Asn  Asn Thr Val Tyr Asp  Pro Leu Gln 
    1115                 1120                 1125             


Ser Glu  Leu Asp Ser Ile Lys  Glu Glu Leu Asp Lys  Ile His Lys 
    1130                 1135                 1140             


Asn Gly  Ser Gly Gly Ser Gly  Asp Ile Ile Lys Leu  Leu Asn Glu 
    1145                 1150                 1155             


Gln Val  Asn Lys Glu Met Gln  Ser Ser Asn Leu Tyr  Met Ser Met 
    1160                 1165                 1170             


Ser Ser  Trp Cys Tyr Thr His  Ser Leu Asp Gly Ala  Gly Leu Phe 
    1175                 1180                 1185             


Leu Phe  Asp His Ala Ala Glu  Glu Tyr Glu His Ala  Lys Lys Leu 
    1190                 1195                 1200             


Ile Ile  Phe Leu Asn Glu Asn  Asn Val Pro Val Gln  Leu Thr Ser 
    1205                 1210                 1215             


Ile Ser  Ala Pro Glu His Lys  Phe Glu Gly Leu Thr  Gln Ile Phe 
    1220                 1225                 1230             


Gln Lys  Ala Tyr Glu His Glu  Gln His Ile Ser Glu  Ser Ile Asn 
    1235                 1240                 1245             


Asn Ile  Val Asp His Ala Ile  Lys Ser Lys Asp His  Ala Thr Phe 
    1250                 1255                 1260             


Asn Phe  Leu Gln Trp Tyr Val  Ala Glu Gln His Glu  Glu Glu Val 
    1265                 1270                 1275             


Leu Phe  Lys Asp Ile Leu Asp  Lys Ile Glu Leu Ile  Gly Asn Glu 
    1280                 1285                 1290             


Asn His  Gly Leu Tyr Leu Ala  Asp Gln Tyr Val Lys  Gly Ile Ala 
    1295                 1300                 1305             


Lys Ser  Arg Lys Ser Gly Ser  
    1310                 1315 


<210> 252
<211> 1315
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 252
Ser Ser Gln Cys Val Asn Phe Thr Thr Arg Thr Gln Leu Pro Pro Ala 
1               5                   10                  15      


Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe 
            20                  25                  30          


Arg Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe 
        35                  40                  45              


Ser Asn Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly 
    50                  55                  60                  


Thr Lys Arg Phe Ala Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr 
65                  70                  75                  80  


Phe Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly 
                85                  90                  95      


Thr Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala 
            100                 105                 110         


Thr Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro 
        115                 120                 125             


Phe Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser 
    130                 135                 140                 


Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val 
145                 150                 155                 160 


Ser Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys 
                165                 170                 175     


Asn Leu Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile 
            180                 185                 190         


Tyr Ser Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly 
        195                 200                 205             


Phe Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile 
    210                 215                 220                 


Thr Arg Phe Gln Thr Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser 
225                 230                 235                 240 


Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu 
                245                 250                 255     


Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr 
            260                 265                 270         


Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr 
        275                 280                 285             


Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe 
    290                 295                 300                 


Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn 
305                 310                 315                 320 


Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val 
                325                 330                 335     


Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser 
            340                 345                 350         


Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val 
        355                 360                 365             


Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp 
    370                 375                 380                 


Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln 
385                 390                 395                 400 


Thr Gly Asn Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr 
                405                 410                 415     


Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly 
            420                 425                 430         


Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys 
        435                 440                 445             


Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr 
    450                 455                 460                 


Pro Cys Asn Gly Val Lys Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser 
465                 470                 475                 480 


Tyr Gly Phe Gln Pro Thr Tyr Gly Val Gly Tyr Gln Pro Tyr Arg Val 
                485                 490                 495     


Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly 
            500                 505                 510         


Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn 
        515                 520                 525             


Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys 
    530                 535                 540                 


Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp 
545                 550                 555                 560 


Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys 
                565                 570                 575     


Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn 
            580                 585                 590         


Gln Val Ala Val Leu Tyr Gln Gly Val Asn Cys Thr Glu Val Pro Val 
        595                 600                 605             


Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr 
    610                 615                 620                 


Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu 
625                 630                 635                 640 


His Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile 
                645                 650                 655     


Cys Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro Gly Ser Ala Ser Ser 
            660                 665                 670         


Val Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Val Glu 
        675                 680                 685             


Asn Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe 
    690                 695                 700                 


Thr Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr 
705                 710                 715                 720 


Ser Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser 
                725                 730                 735     


Asn Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala 
            740                 745                 750         


Leu Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe 
        755                 760                 765             


Ala Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly 
    770                 775                 780                 


Gly Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys 
785                 790                 795                 800 


Arg Ser Pro Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp 
                805                 810                 815     


Ala Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala 
            820                 825                 830         


Arg Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro 
        835                 840                 845             


Pro Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu 
    850                 855                 860                 


Ala Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Pro Ala Leu 
865                 870                 875                 880 


Gln Ile Pro Phe Pro Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly 
                885                 890                 895     


Val Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln 
            900                 905                 910         


Phe Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Pro 
        915                 920                 925             


Ser Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala 
    930                 935                 940                 


Leu Asn Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser 
945                 950                 955                 960 


Ser Val Leu Asn Asp Ile Leu Ser Arg Leu Asp Pro Pro Glu Ala Glu 
                965                 970                 975     


Val Gln Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser Leu Gln Thr 
            980                 985                 990         


Tyr Val Thr Gln Gln Leu Ile Arg  Ala Ala Glu Ile Arg  Ala Ser Ala 
        995                 1000                 1005             


Asn Leu  Ala Ala Thr Lys Met  Ser Glu Cys Val Leu  Gly Gln Ser 
    1010                 1015                 1020             


Lys Arg  Val Asp Phe Cys Gly  Lys Gly Tyr His Leu  Met Ser Phe 
    1025                 1030                 1035             


Pro Gln  Ser Ala Pro His Gly  Val Val Phe Leu His  Val Thr Tyr 
    1040                 1045                 1050             


Val Pro  Ala Gln Glu Lys Asn  Phe Thr Thr Ala Pro  Ala Ile Cys 
    1055                 1060                 1065             


His Asp  Gly Lys Ala His Phe  Pro Arg Glu Gly Val  Phe Val Ser 
    1070                 1075                 1080             


Asn Gly  Thr His Trp Phe Val  Thr Gln Arg Asn Phe  Tyr Glu Pro 
    1085                 1090                 1095             


Gln Ile  Ile Thr Thr Asp Asn  Thr Phe Val Ser Gly  Asn Cys Asp 
    1100                 1105                 1110             


Val Val  Ile Gly Ile Val Asn  Asn Thr Val Tyr Asp  Pro Leu Gln 
    1115                 1120                 1125             


Ser Glu  Leu Asp Ser Ile Lys  Glu Glu Leu Asp Lys  Ile His Lys 
    1130                 1135                 1140             


Asn Gly  Ser Gly Gly Ser Gly  Asp Ile Ile Lys Leu  Leu Asn Glu 
    1145                 1150                 1155             


Gln Val  Asn Lys Glu Met Gln  Ser Ser Asn Leu Tyr  Met Ser Met 
    1160                 1165                 1170             


Ser Ser  Trp Cys Tyr Thr His  Ser Leu Asp Gly Ala  Gly Leu Phe 
    1175                 1180                 1185             


Leu Phe  Asp His Ala Ala Glu  Glu Tyr Glu His Ala  Lys Lys Leu 
    1190                 1195                 1200             


Ile Ile  Phe Leu Asn Glu Asn  Asn Val Pro Val Gln  Leu Thr Ser 
    1205                 1210                 1215             


Ile Ser  Ala Pro Glu His Lys  Phe Glu Gly Leu Thr  Gln Ile Phe 
    1220                 1225                 1230             


Gln Lys  Ala Tyr Glu His Glu  Gln His Ile Ser Glu  Ser Ile Asn 
    1235                 1240                 1245             


Asn Ile  Val Asp His Ala Ile  Lys Ser Lys Asp His  Ala Thr Phe 
    1250                 1255                 1260             


Asn Phe  Leu Gln Trp Tyr Val  Ala Glu Gln His Glu  Glu Glu Val 
    1265                 1270                 1275             


Leu Phe  Lys Asp Ile Leu Asp  Lys Ile Glu Leu Ile  Gly Asn Glu 
    1280                 1285                 1290             


Asn His  Gly Leu Tyr Leu Ala  Asp Gln Tyr Val Lys  Gly Ile Ala 
    1295                 1300                 1305             


Lys Ser  Arg Lys Ser Gly Ser  
    1310                 1315 


<210> 253
<211> 1318
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 253
Ser Ser Gln Cys Val Asn Phe Thr Asn Arg Thr Gln Leu Pro Ser Ala 
1               5                   10                  15      


Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe 
            20                  25                  30          


Arg Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe 
        35                  40                  45              


Ser Asn Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly 
    50                  55                  60                  


Thr Lys Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr 
65                  70                  75                  80  


Phe Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly 
                85                  90                  95      


Thr Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala 
            100                 105                 110         


Thr Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Tyr Pro 
        115                 120                 125             


Phe Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser 
    130                 135                 140                 


Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val 
145                 150                 155                 160 


Ser Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys 
                165                 170                 175     


Asn Leu Ser Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile 
            180                 185                 190         


Tyr Ser Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly 
        195                 200                 205             


Phe Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile 
    210                 215                 220                 


Thr Arg Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro 
225                 230                 235                 240 


Gly Asp Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val 
                245                 250                 255     


Gly Tyr Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly 
            260                 265                 270         


Thr Ile Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr 
        275                 280                 285             


Lys Cys Thr Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr 
    290                 295                 300                 


Ser Asn Phe Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn 
305                 310                 315                 320 


Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe 
                325                 330                 335     


Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala 
            340                 345                 350         


Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys 
        355                 360                 365             


Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val 
    370                 375                 380                 


Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala 
385                 390                 395                 400 


Pro Gly Gln Thr Gly Thr Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp 
                405                 410                 415     


Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser 
            420                 425                 430         


Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser 
        435                 440                 445             


Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala 
    450                 455                 460                 


Gly Ser Thr Pro Cys Asn Gly Val Lys Gly Phe Asn Cys Tyr Phe Pro 
465                 470                 475                 480 


Leu Gln Ser Tyr Gly Phe Gln Pro Thr Tyr Gly Val Gly Tyr Gln Pro 
                485                 490                 495     


Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr 
            500                 505                 510         


Val Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val 
        515                 520                 525             


Asn Phe Asn Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser 
    530                 535                 540                 


Asn Lys Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp 
545                 550                 555                 560 


Thr Thr Asp Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile 
                565                 570                 575     


Thr Pro Cys Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn 
            580                 585                 590         


Thr Ser Asn Gln Val Ala Val Leu Tyr Gln Gly Val Asn Cys Thr Glu 
        595                 600                 605             


Val Pro Val Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val 
    610                 615                 620                 


Tyr Ser Thr Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile 
625                 630                 635                 640 


Gly Ala Glu Tyr Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly 
                645                 650                 655     


Ala Gly Ile Cys Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro Gly Ser 
            660                 665                 670         


Ala Ser Ser Val Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu 
        675                 680                 685             


Gly Ala Glu Asn Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro 
    690                 695                 700                 


Thr Asn Phe Thr Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met 
705                 710                 715                 720 


Thr Lys Thr Ser Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr 
                725                 730                 735     


Glu Cys Ser Asn Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu 
            740                 745                 750         


Asn Arg Ala Leu Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln 
        755                 760                 765             


Glu Val Phe Ala Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys 
    770                 775                 780                 


Asp Phe Gly Gly Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys 
785                 790                 795                 800 


Pro Ser Lys Arg Ser Pro Ile Glu Asp Leu Leu Phe Asn Lys Val Thr 
                805                 810                 815     


Leu Ala Asp Ala Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp 
            820                 825                 830         


Ile Ala Ala Arg Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr 
        835                 840                 845             


Val Leu Pro Pro Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser 
    850                 855                 860                 


Ala Leu Leu Ala Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly 
865                 870                 875                 880 


Pro Ala Leu Gln Ile Pro Phe Pro Met Gln Met Ala Tyr Arg Phe Asn 
                885                 890                 895     


Gly Ile Gly Val Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile 
            900                 905                 910         


Ala Asn Gln Phe Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser 
        915                 920                 925             


Ser Thr Pro Ser Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn 
    930                 935                 940                 


Ala Gln Ala Leu Asn Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly 
945                 950                 955                 960 


Ala Ile Ser Ser Val Leu Asn Asp Ile Leu Ser Arg Leu Asp Pro Pro 
                965                 970                 975     


Glu Ala Glu Val Gln Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser 
            980                 985                 990         


Leu Gln Thr Tyr Val Thr Gln Gln  Leu Ile Arg Ala Ala  Glu Ile Arg 
        995                 1000                 1005             


Ala Ser  Ala Asn Leu Ala Ala  Ile Lys Met Ser Glu  Cys Val Leu 
    1010                 1015                 1020             


Gly Gln  Ser Lys Arg Val Asp  Phe Cys Gly Lys Gly  Tyr His Leu 
    1025                 1030                 1035             


Met Ser  Phe Pro Gln Ser Ala  Pro His Gly Val Val  Phe Leu His 
    1040                 1045                 1050             


Val Thr  Tyr Val Pro Ala Gln  Glu Lys Asn Phe Thr  Thr Ala Pro 
    1055                 1060                 1065             


Ala Ile  Cys His Asp Gly Lys  Ala His Phe Pro Arg  Glu Gly Val 
    1070                 1075                 1080             


Phe Val  Ser Asn Gly Thr His  Trp Phe Val Thr Gln  Arg Asn Phe 
    1085                 1090                 1095             


Tyr Glu  Pro Gln Ile Ile Thr  Thr Asp Asn Thr Phe  Val Ser Gly 
    1100                 1105                 1110             


Asn Cys  Asp Val Val Ile Gly  Ile Val Asn Asn Thr  Val Tyr Asp 
    1115                 1120                 1125             


Pro Leu  Gln Ser Glu Leu Asp  Ser Ile Lys Glu Glu  Leu Asp Lys 
    1130                 1135                 1140             


Ile His  Lys Asn Gly Ser Gly  Gly Ser Gly Asp Ile  Ile Lys Leu 
    1145                 1150                 1155             


Leu Asn  Glu Gln Val Asn Lys  Glu Met Gln Ser Ser  Asn Leu Tyr 
    1160                 1165                 1170             


Met Ser  Met Ser Ser Trp Cys  Tyr Thr His Ser Leu  Asp Gly Ala 
    1175                 1180                 1185             


Gly Leu  Phe Leu Phe Asp His  Ala Ala Glu Glu Tyr  Glu His Ala 
    1190                 1195                 1200             


Lys Lys  Leu Ile Ile Phe Leu  Asn Glu Asn Asn Val  Pro Val Gln 
    1205                 1210                 1215             


Leu Thr  Ser Ile Ser Ala Pro  Glu His Lys Phe Glu  Gly Leu Thr 
    1220                 1225                 1230             


Gln Ile  Phe Gln Lys Ala Tyr  Glu His Glu Gln His  Ile Ser Glu 
    1235                 1240                 1245             


Ser Ile  Asn Asn Ile Val Asp  His Ala Ile Lys Ser  Lys Asp His 
    1250                 1255                 1260             


Ala Thr  Phe Asn Phe Leu Gln  Trp Tyr Val Ala Glu  Gln His Glu 
    1265                 1270                 1275             


Glu Glu  Val Leu Phe Lys Asp  Ile Leu Asp Lys Ile  Glu Leu Ile 
    1280                 1285                 1290             


Gly Asn  Glu Asn His Gly Leu  Tyr Leu Ala Asp Gln  Tyr Val Lys 
    1295                 1300                 1305             


Gly Ile  Ala Lys Ser Arg Lys  Ser Gly Ser 
    1310                 1315             


<210> 254
<211> 1332
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 254
Ser Ser Gln Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala 
1               5                   10                  15      


Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe 
            20                  25                  30          


Arg Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe 
        35                  40                  45              


Ser Asn Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly 
    50                  55                  60                  


Thr Lys Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr 
65                  70                  75                  80  


Phe Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly 
                85                  90                  95      


Thr Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala 
            100                 105                 110         


Thr Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro 
        115                 120                 125             


Phe Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser 
    130                 135                 140                 


Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val 
145                 150                 155                 160 


Ser Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys 
                165                 170                 175     


Asn Leu Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile 
            180                 185                 190         


Tyr Ser Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly 
        195                 200                 205             


Phe Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile 
    210                 215                 220                 


Thr Arg Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro 
225                 230                 235                 240 


Gly Asp Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val 
                245                 250                 255     


Gly Tyr Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly 
            260                 265                 270         


Thr Ile Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr 
        275                 280                 285             


Lys Cys Thr Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr 
    290                 295                 300                 


Ser Asn Phe Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn 
305                 310                 315                 320 


Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe 
                325                 330                 335     


Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala 
            340                 345                 350         


Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys 
        355                 360                 365             


Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val 
    370                 375                 380                 


Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala 
385                 390                 395                 400 


Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp 
                405                 410                 415     


Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser 
            420                 425                 430         


Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser 
        435                 440                 445             


Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala 
    450                 455                 460                 


Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro 
465                 470                 475                 480 


Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro 
                485                 490                 495     


Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr 
            500                 505                 510         


Val Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val 
        515                 520                 525             


Asn Phe Asn Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser 
    530                 535                 540                 


Asn Lys Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp 
545                 550                 555                 560 


Thr Thr Asp Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile 
                565                 570                 575     


Thr Pro Cys Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn 
            580                 585                 590         


Thr Ser Asn Gln Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu 
        595                 600                 605             


Val Pro Val Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val 
    610                 615                 620                 


Tyr Ser Thr Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile 
625                 630                 635                 640 


Gly Ala Glu His Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly 
                645                 650                 655     


Ala Gly Ile Cys Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro Gly Ser 
            660                 665                 670         


Ala Ser Ser Val Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu 
        675                 680                 685             


Gly Ala Glu Asn Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro 
    690                 695                 700                 


Thr Asn Phe Thr Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met 
705                 710                 715                 720 


Thr Lys Thr Ser Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr 
                725                 730                 735     


Glu Cys Ser Asn Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu 
            740                 745                 750         


Asn Arg Ala Leu Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln 
        755                 760                 765             


Glu Val Phe Ala Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys 
    770                 775                 780                 


Asp Phe Gly Gly Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys 
785                 790                 795                 800 


Pro Ser Lys Arg Ser Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr 
                805                 810                 815     


Leu Ala Asp Ala Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp 
            820                 825                 830         


Ile Ala Ala Arg Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr 
        835                 840                 845             


Val Leu Pro Pro Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser 
    850                 855                 860                 


Ala Leu Leu Ala Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly 
865                 870                 875                 880 


Ala Ala Leu Gln Ile Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn 
                885                 890                 895     


Gly Ile Gly Val Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile 
            900                 905                 910         


Ala Asn Gln Phe Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser 
        915                 920                 925             


Ser Thr Ala Ser Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn 
    930                 935                 940                 


Ala Gln Ala Leu Asn Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly 
945                 950                 955                 960 


Ala Ile Ser Ser Val Leu Asn Asp Ile Leu Ser Arg Leu Asp Pro Pro 
                965                 970                 975     


Glu Ala Glu Val Gln Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser 
            980                 985                 990         


Leu Gln Thr Tyr Val Thr Gln Gln  Leu Ile Arg Ala Ala  Glu Ile Arg 
        995                 1000                 1005             


Ala Ser  Ala Asn Leu Ala Ala  Thr Lys Met Ser Glu  Cys Val Leu 
    1010                 1015                 1020             


Gly Gln  Ser Lys Arg Val Asp  Phe Cys Gly Lys Gly  Tyr His Leu 
    1025                 1030                 1035             


Met Ser  Phe Pro Gln Ser Ala  Pro His Gly Val Val  Phe Leu His 
    1040                 1045                 1050             


Val Thr  Tyr Val Pro Ala Gln  Glu Lys Asn Phe Thr  Thr Ala Pro 
    1055                 1060                 1065             


Ala Ile  Cys His Asp Gly Lys  Ala His Phe Pro Arg  Glu Gly Val 
    1070                 1075                 1080             


Phe Val  Ser Asn Gly Thr His  Trp Phe Val Thr Gln  Arg Asn Phe 
    1085                 1090                 1095             


Tyr Glu  Pro Gln Ile Ile Thr  Thr Asp Asn Thr Phe  Val Ser Gly 
    1100                 1105                 1110             


Asn Cys  Asp Val Val Ile Gly  Ile Val Asn Asn Thr  Val Tyr Asp 
    1115                 1120                 1125             


Pro Leu  Gln Ser Glu Leu Asp  Ser Ile Lys Glu Glu  Leu Asp Lys 
    1130                 1135                 1140             


Ile His  Lys Asn Leu Thr Ser  Ile Lys Glu Glu Leu  Asp Lys Ile 
    1145                 1150                 1155             


His Lys  Asn Gly Ser Gly Gly  Ser Gly Asp Ile Ile  Lys Leu Leu 
    1160                 1165                 1170             


Asn Glu  Gln Val Asn Lys Glu  Met Gln Ser Ser Asn  Leu Tyr Met 
    1175                 1180                 1185             


Ser Met  Ser Ser Trp Cys Tyr  Thr His Ser Leu Asp  Gly Ala Gly 
    1190                 1195                 1200             


Leu Phe  Leu Phe Asp His Ala  Ala Glu Glu Tyr Glu  His Ala Lys 
    1205                 1210                 1215             


Lys Leu  Ile Ile Phe Leu Asn  Glu Asn Asn Val Pro  Val Gln Leu 
    1220                 1225                 1230             


Thr Ser  Ile Ser Ala Pro Glu  His Lys Phe Glu Gly  Leu Thr Gln 
    1235                 1240                 1245             


Ile Phe  Gln Lys Ala Tyr Glu  His Glu Gln His Ile  Ser Glu Ser 
    1250                 1255                 1260             


Ile Asn  Asn Ile Val Asp His  Ala Ile Lys Ser Lys  Asp His Ala 
    1265                 1270                 1275             


Thr Phe  Asn Phe Leu Gln Trp  Tyr Val Ala Glu Gln  His Glu Glu 
    1280                 1285                 1290             


Glu Val  Leu Phe Lys Asp Ile  Leu Asp Lys Ile Glu  Leu Ile Gly 
    1295                 1300                 1305             


Asn Glu  Asn His Gly Leu Tyr  Leu Ala Asp Gln Tyr  Val Lys Gly 
    1310                 1315                 1320             


Ile Ala  Lys Ser Arg Lys Ser  Gly Ser 
    1325                 1330         


<210> 255
<211> 1298
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 255
Ser Asp Leu Asp Arg Cys Thr Thr Phe Asp Asp Val Gln Ala Pro Asn 
1               5                   10                  15      


Tyr Thr Gln His Thr Ser Ser Met Arg Gly Val Tyr Tyr Pro Asp Glu 
            20                  25                  30          


Ile Phe Arg Ser Asp Thr Leu Tyr Leu Thr Gln Asp Leu Phe Leu Pro 
        35                  40                  45              


Phe Tyr Ser Asn Val Thr Gly Phe His Thr Ile Asn His Thr Phe Gly 
    50                  55                  60                  


Asn Pro Val Ile Pro Phe Lys Asp Gly Ile Tyr Phe Ala Ala Thr Glu 
65                  70                  75                  80  


Lys Ser Asn Val Val Arg Gly Trp Val Phe Gly Ser Thr Met Asn Asn 
                85                  90                  95      


Lys Ser Gln Ser Val Ile Ile Ile Asn Asn Ser Thr Asn Val Val Ile 
            100                 105                 110         


Arg Ala Cys Asn Phe Glu Leu Cys Asp Asn Pro Phe Phe Ala Val Ser 
        115                 120                 125             


Lys Pro Met Gly Thr Gln Thr His Thr Met Ile Phe Asp Asn Ala Phe 
    130                 135                 140                 


Asn Cys Thr Phe Glu Tyr Ile Ser Asp Ala Phe Ser Leu Asp Val Ser 
145                 150                 155                 160 


Glu Lys Ser Gly Asn Phe Lys His Leu Arg Glu Phe Val Phe Lys Asn 
                165                 170                 175     


Lys Asp Gly Phe Leu Tyr Val Tyr Lys Gly Tyr Gln Pro Ile Asp Val 
            180                 185                 190         


Val Arg Asp Leu Pro Ser Gly Phe Asn Thr Leu Lys Pro Ile Phe Lys 
        195                 200                 205             


Leu Pro Leu Gly Ile Asn Ile Thr Asn Phe Arg Ala Ile Leu Thr Ala 
    210                 215                 220                 


Phe Ser Pro Ala Gln Asp Ile Trp Gly Thr Ser Ala Ala Ala Tyr Phe 
225                 230                 235                 240 


Val Gly Tyr Leu Lys Pro Thr Thr Phe Met Leu Lys Tyr Asp Glu Asn 
                245                 250                 255     


Gly Thr Ile Thr Asp Ala Val Asp Cys Ser Gln Asn Pro Leu Ala Glu 
            260                 265                 270         


Leu Lys Cys Ser Val Lys Ser Phe Glu Ile Asp Lys Gly Ile Tyr Gln 
        275                 280                 285             


Thr Ser Asn Phe Arg Val Val Pro Ser Gly Asp Val Val Arg Phe Pro 
    290                 295                 300                 


Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Lys 
305                 310                 315                 320 


Phe Pro Ser Val Tyr Ala Trp Glu Arg Lys Lys Ile Ser Asn Cys Val 
                325                 330                 335     


Ala Asp Tyr Ser Val Leu Tyr Asn Ser Thr Phe Phe Ser Thr Phe Lys 
            340                 345                 350         


Cys Tyr Gly Val Ser Ala Thr Lys Leu Asn Asp Leu Cys Phe Ser Asn 
        355                 360                 365             


Val Tyr Ala Asp Ser Phe Val Val Lys Gly Asp Asp Val Arg Gln Ile 
    370                 375                 380                 


Ala Pro Gly Gln Thr Gly Val Ile Ala Asp Tyr Asn Tyr Lys Leu Pro 
385                 390                 395                 400 


Asp Asp Phe Met Gly Cys Val Leu Ala Trp Asn Thr Arg Asn Ile Asp 
                405                 410                 415     


Ala Thr Ser Thr Gly Asn Tyr Asn Tyr Lys Tyr Arg Tyr Leu Arg His 
            420                 425                 430         


Gly Lys Leu Arg Pro Phe Glu Arg Asp Ile Ser Asn Val Pro Phe Ser 
        435                 440                 445             


Pro Asp Gly Lys Pro Cys Thr Pro Pro Ala Leu Asn Cys Tyr Trp Pro 
    450                 455                 460                 


Leu Asn Asp Tyr Gly Phe Tyr Thr Thr Thr Gly Ile Gly Tyr Gln Pro 
465                 470                 475                 480 


Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu Asn Ala Pro Ala Thr 
                485                 490                 495     


Val Cys Gly Pro Lys Leu Ser Thr Asp Leu Ile Lys Asn Gln Cys Val 
            500                 505                 510         


Asn Phe Asn Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Pro Ser 
        515                 520                 525             


Ser Lys Arg Phe Gln Pro Phe Gln Gln Phe Gly Arg Asp Val Ser Asp 
    530                 535                 540                 


Phe Thr Asp Ser Val Arg Asp Pro Lys Thr Ser Glu Ile Leu Asp Ile 
545                 550                 555                 560 


Ser Pro Cys Ala Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn 
                565                 570                 575     


Ala Ser Ser Glu Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Asp 
            580                 585                 590         


Val Ser Thr Ala Ile His Ala Asp Gln Leu Thr Pro Ala Trp Arg Ile 
        595                 600                 605             


Tyr Ser Thr Gly Asn Asn Val Phe Gln Thr Gln Ala Gly Cys Leu Ile 
    610                 615                 620                 


Gly Ala Glu His Val Asp Thr Ser Tyr Glu Cys Asp Ile Pro Ile Gly 
625                 630                 635                 640 


Ala Gly Ile Cys Ala Ser Tyr His Thr Val Ser Leu Leu Arg Ser Thr 
                645                 650                 655     


Ser Gln Lys Ser Ile Val Ala Tyr Thr Met Ser Leu Gly Ala Asp Ser 
            660                 665                 670         


Ser Ile Ala Tyr Ser Asn Asn Thr Ile Ala Ile Pro Thr Asn Phe Ser 
        675                 680                 685             


Ile Ser Ile Thr Thr Glu Val Met Pro Val Ser Met Ala Lys Thr Ser 
    690                 695                 700                 


Val Asp Cys Asn Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ala Asn 
705                 710                 715                 720 


Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu 
                725                 730                 735     


Ser Gly Ile Ala Ala Glu Gln Asp Arg Asn Thr Arg Glu Val Phe Ala 
            740                 745                 750         


Gln Val Lys Gln Met Tyr Lys Thr Pro Thr Leu Lys Tyr Phe Gly Gly 
        755                 760                 765             


Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Leu Lys Pro Thr Lys Arg 
    770                 775                 780                 


Ser Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala 
785                 790                 795                 800 


Gly Phe Met Lys Gln Tyr Gly Glu Cys Leu Gly Asp Ile Asn Ala Arg 
                805                 810                 815     


Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro 
            820                 825                 830         


Leu Leu Thr Asp Asp Met Ile Ala Ala Tyr Thr Ala Ala Leu Val Ser 
        835                 840                 845             


Gly Thr Ala Thr Ala Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln 
    850                 855                 860                 


Ile Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val 
865                 870                 875                 880 


Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Gln Ile Ala Asn Gln Phe 
                885                 890                 895     


Asn Lys Ala Ile Ser Gln Ile Gln Glu Ser Leu Thr Thr Thr Ser Thr 
            900                 905                 910         


Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu 
        915                 920                 925             


Asn Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser 
    930                 935                 940                 


Val Leu Asn Asp Ile Leu Ser Arg Leu Asp Pro Pro Glu Ala Glu Val 
945                 950                 955                 960 


Gln Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser Leu Gln Thr Tyr 
                965                 970                 975     


Val Thr Gln Gln Leu Ile Arg Ala Ala Glu Ile Arg Ala Ser Ala Asn 
            980                 985                 990         


Leu Ala Ala Thr Lys Met Ser Glu  Cys Val Leu Gly Gln  Ser Lys Arg 
        995                 1000                 1005             


Val Asp  Phe Cys Gly Lys Gly  Tyr His Leu Met Ser  Phe Pro Gln 
    1010                 1015                 1020             


Ala Ala  Pro His Gly Val Val  Phe Leu His Val Thr  Tyr Val Pro 
    1025                 1030                 1035             


Ser Gln  Glu Arg Asn Phe Thr  Thr Ala Pro Ala Ile  Cys His Glu 
    1040                 1045                 1050             


Gly Lys  Ala Tyr Phe Pro Arg  Glu Gly Val Phe Val  Phe Asn Gly 
    1055                 1060                 1065             


Thr Ser  Trp Phe Ile Thr Gln  Arg Asn Phe Phe Ser  Pro Gln Ile 
    1070                 1075                 1080             


Ile Thr  Thr Asp Asn Thr Phe  Val Ser Gly Asn Cys  Asp Val Val 
    1085                 1090                 1095             


Ile Gly  Ile Ile Asn Asn Thr  Val Tyr Asp Pro Leu  Gln Ser Glu 
    1100                 1105                 1110             


Leu Asp  Ser Ile Lys Glu Glu  Leu Asp Lys Ile His  Lys Asn Gly 
    1115                 1120                 1125             


Ser Gly  Gly Ser Gly Asp Ile  Ile Lys Leu Leu Asn  Glu Gln Val 
    1130                 1135                 1140             


Asn Lys  Glu Met Gln Ser Ser  Asn Leu Tyr Met Ser  Met Ser Ser 
    1145                 1150                 1155             


Trp Cys  Tyr Thr His Ser Leu  Asp Gly Ala Gly Leu  Phe Leu Phe 
    1160                 1165                 1170             


Asp His  Ala Ala Glu Glu Tyr  Glu His Ala Lys Lys  Leu Ile Ile 
    1175                 1180                 1185             


Phe Leu  Asn Glu Asn Asn Val  Pro Val Gln Leu Thr  Ser Ile Ser 
    1190                 1195                 1200             


Ala Pro  Glu His Lys Phe Glu  Gly Leu Thr Gln Ile  Phe Gln Lys 
    1205                 1210                 1215             


Ala Tyr  Glu His Glu Gln His  Ile Ser Glu Ser Ile  Asn Asn Ile 
    1220                 1225                 1230             


Val Asp  His Ala Ile Lys Ser  Lys Asp His Ala Thr  Phe Asn Phe 
    1235                 1240                 1245             


Leu Gln  Trp Tyr Val Ala Glu  Gln His Glu Glu Glu  Val Leu Phe 
    1250                 1255                 1260             


Lys Asp  Ile Leu Asp Lys Ile  Glu Leu Ile Gly Asn  Glu Asn His 
    1265                 1270                 1275             


Gly Leu  Tyr Leu Ala Asp Gln  Tyr Val Lys Gly Ile  Ala Lys Ser 
    1280                 1285                 1290             


Arg Lys  Ser Gly Ser 
    1295             


<210> 256
<211> 1401
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 256
Ala Val Ile Gly Asp Leu Lys Cys Thr Ser Asp Asn Ile Asn Asp Lys 
1               5                   10                  15      


Asp Thr Gly Pro Pro Pro Ile Ser Thr Asp Thr Val Asp Val Thr Asn 
            20                  25                  30          


Gly Leu Gly Thr Tyr Tyr Val Leu Asp Arg Val Tyr Leu Asn Thr Thr 
        35                  40                  45              


Leu Phe Leu Asn Gly Tyr Tyr Pro Thr Ser Gly Ser Thr Tyr Arg Asn 
    50                  55                  60                  


Met Ala Leu Lys Gly Ser Val Leu Leu Ser Arg Leu Trp Phe Lys Pro 
65                  70                  75                  80  


Pro Phe Leu Ser Asp Phe Ile Asn Gly Ile Phe Ala Lys Val Lys Asn 
                85                  90                  95      


Thr Lys Val Ile Lys Asp Arg Val Met Tyr Ser Glu Phe Pro Ala Ile 
            100                 105                 110         


Thr Ile Gly Ser Thr Phe Val Asn Thr Ser Tyr Ser Val Val Val Gln 
        115                 120                 125             


Pro Arg Thr Ile Asn Ser Thr Gln Asp Gly Asp Asn Lys Leu Gln Gly 
    130                 135                 140                 


Leu Leu Glu Val Ser Val Cys Gln Tyr Asn Met Cys Glu Tyr Pro Gln 
145                 150                 155                 160 


Thr Ile Cys His Pro Asn Leu Gly Asn His Arg Lys Glu Leu Trp His 
                165                 170                 175     


Leu Asp Thr Gly Val Val Ser Cys Leu Tyr Lys Arg Asn Phe Thr Tyr 
            180                 185                 190         


Asp Val Asn Ala Asp Tyr Leu Tyr Phe His Phe Tyr Gln Glu Gly Gly 
        195                 200                 205             


Thr Phe Tyr Ala Tyr Phe Thr Asp Thr Gly Val Val Thr Lys Phe Leu 
    210                 215                 220                 


Phe Asn Val Tyr Leu Gly Met Ala Leu Ser His Tyr Tyr Val Met Pro 
225                 230                 235                 240 


Leu Thr Cys Asn Ser Lys Leu Thr Leu Glu Tyr Trp Val Thr Pro Leu 
                245                 250                 255     


Thr Ser Arg Gln Tyr Leu Leu Ala Phe Asn Gln Asp Gly Ile Ile Phe 
            260                 265                 270         


Asn Ala Val Asp Cys Met Ser Asp Phe Met Ser Glu Ile Lys Cys Lys 
        275                 280                 285             


Thr Gln Ser Ile Ala Pro Pro Thr Gly Val Tyr Glu Leu Asn Gly Tyr 
    290                 295                 300                 


Thr Val Gln Pro Ile Ala Asp Val Tyr Arg Arg Lys Pro Asn Leu Pro 
305                 310                 315                 320 


Asn Cys Asn Ile Glu Ala Trp Leu Asn Asp Lys Ser Val Pro Ser Pro 
                325                 330                 335     


Leu Asn Trp Glu Arg Lys Thr Phe Ser Asn Cys Asn Phe Asn Met Ser 
            340                 345                 350         


Ser Leu Met Ser Phe Ile Gln Ala Asp Ser Phe Thr Cys Asn Asn Ile 
        355                 360                 365             


Asp Ala Ala Lys Ile Tyr Gly Met Cys Phe Ser Ser Ile Thr Ile Asp 
    370                 375                 380                 


Lys Phe Ala Ile Pro Asn Gly Arg Lys Val Asp Leu Gln Leu Gly Asn 
385                 390                 395                 400 


Leu Gly Tyr Leu Gln Ser Phe Asn Tyr Arg Ile Asp Thr Thr Ala Thr 
                405                 410                 415     


Ser Cys Gln Leu Tyr Tyr Asn Leu Pro Ala Ala Asn Val Ser Val Ser 
            420                 425                 430         


Arg Phe Asn Pro Ser Thr Trp Asn Lys Arg Phe Gly Phe Ile Glu Asp 
        435                 440                 445             


Ser Val Phe Lys Pro Arg Pro Ala Gly Val Leu Thr Asn His Asp Val 
    450                 455                 460                 


Val Tyr Ala Gln His Cys Phe Lys Ala Pro Lys Asn Phe Cys Pro Cys 
465                 470                 475                 480 


Lys Leu Asn Gly Ser Cys Val Gly Ser Gly Pro Gly Lys Asn Asn Gly 
                485                 490                 495     


Ile Gly Thr Cys Pro Ala Gly Thr Asn Tyr Leu Thr Cys Asp Asn Leu 
            500                 505                 510         


Cys Thr Pro Asp Pro Ile Thr Phe Thr Gly Thr Tyr Lys Cys Pro Gln 
        515                 520                 525             


Thr Lys Ser Leu Val Gly Ile Gly Glu His Cys Ser Gly Leu Ala Val 
    530                 535                 540                 


Lys Ser Asp Tyr Cys Gly Gly Asn Ser Cys Thr Cys Arg Pro Gln Ala 
545                 550                 555                 560 


Phe Leu Gly Trp Ser Ala Asp Ser Cys Leu Gln Gly Asp Lys Cys Asn 
                565                 570                 575     


Ile Phe Ala Asn Phe Ile Leu His Asp Val Asn Ser Gly Leu Thr Cys 
            580                 585                 590         


Ser Thr Asp Leu Gln Lys Ala Asn Thr Asp Ile Ile Leu Gly Val Cys 
        595                 600                 605             


Val Asn Tyr Asp Leu Tyr Gly Ile Leu Gly Gln Gly Ile Phe Val Glu 
    610                 615                 620                 


Val Asn Ala Thr Tyr Tyr Asn Ser Trp Gln Asn Leu Leu Tyr Asp Ser 
625                 630                 635                 640 


Asn Gly Asn Leu Tyr Gly Phe Arg Asp Tyr Ile Thr Asn Arg Thr Phe 
                645                 650                 655     


Met Ile Arg Ser Cys Tyr Ser Gly Arg Val Ser Ala Ala Phe His Ala 
            660                 665                 670         


Asn Ser Ser Glu Pro Ala Leu Leu Phe Arg Asn Ile Lys Cys Asn Tyr 
        675                 680                 685             


Val Phe Asn Asn Ser Leu Thr Arg Gln Leu Gln Pro Ile Asn Tyr Phe 
    690                 695                 700                 


Asp Ser Tyr Leu Gly Cys Val Val Asn Ala Tyr Asn Ser Thr Ala Ile 
705                 710                 715                 720 


Ser Val Gln Thr Cys Asp Leu Thr Val Gly Ser Gly Tyr Cys Val Asp 
                725                 730                 735     


Tyr Ser Lys Asn Gly Gly Ser Gly Gly Ala Ile Thr Thr Gly Tyr Arg 
            740                 745                 750         


Phe Thr Asn Phe Glu Pro Phe Thr Val Asn Ser Val Asn Asp Ser Leu 
        755                 760                 765             


Glu Pro Val Gly Gly Leu Tyr Glu Ile Gln Ile Pro Ser Glu Phe Thr 
    770                 775                 780                 


Ile Gly Asn Met Val Glu Phe Ile Gln Thr Ser Ser Pro Lys Val Thr 
785                 790                 795                 800 


Ile Asp Cys Ala Ala Phe Val Cys Gly Asp Tyr Ala Ala Cys Lys Ser 
                805                 810                 815     


Gln Leu Val Glu Tyr Gly Ser Phe Cys Asp Asn Ile Asn Ala Ile Leu 
            820                 825                 830         


Thr Glu Val Asn Glu Leu Leu Asp Thr Thr Gln Leu Gln Val Ala Asn 
        835                 840                 845             


Ser Leu Met Asn Gly Val Thr Leu Ser Thr Lys Leu Lys Asp Gly Val 
    850                 855                 860                 


Asn Phe Asn Val Asp Asp Ile Asn Phe Ser Pro Val Leu Gly Cys Leu 
865                 870                 875                 880 


Gly Ser Glu Cys Ser Lys Ala Ser Ser Arg Ser Ala Ile Glu Asp Leu 
                885                 890                 895     


Leu Phe Asp Lys Val Lys Leu Ser Asp Val Gly Phe Val Glu Ala Tyr 
            900                 905                 910         


Asn Asn Cys Thr Gly Gly Ala Glu Ile Arg Asp Leu Ile Cys Val Gln 
        915                 920                 925             


Ser Tyr Lys Gly Ile Lys Val Leu Pro Pro Leu Leu Ser Glu Asn Gln 
    930                 935                 940                 


Phe Ser Gly Tyr Thr Leu Ala Ala Thr Ser Ala Ser Leu Phe Pro Pro 
945                 950                 955                 960 


Trp Thr Ala Ala Ala Gly Val Pro Phe Tyr Leu Asn Val Gln Tyr Arg 
                965                 970                 975     


Ile Asn Gly Leu Gly Val Thr Met Asp Val Leu Ser Gln Asn Gln Lys 
            980                 985                 990         


Leu Ile Ala Asn Ala Phe Asn Asn  Ala Leu Tyr Ala Ile  Gln Glu Gly 
        995                 1000                 1005             


Phe Asp  Ala Thr Asn Ser Ala  Leu Val Lys Ile Gln  Ala Val Val 
    1010                 1015                 1020             


Asn Ala  Asn Ala Glu Ala Leu  Asn Asn Leu Leu Gln  Gln Leu Ser 
    1025                 1030                 1035             


Asn Arg  Phe Gly Ala Ile Ser  Ala Ser Leu Gln Glu  Ile Leu Ser 
    1040                 1045                 1050             


Arg Leu  Asp Pro Pro Glu Ala  Glu Ala Gln Ile Asp  Arg Leu Ile 
    1055                 1060                 1065             


Asn Gly  Arg Leu Thr Ala Leu  Asn Ala Tyr Val Ser  Gln Gln Leu 
    1070                 1075                 1080             


Ser Asp  Ser Thr Leu Val Lys  Phe Ser Ala Ala Gln  Ala Met Glu 
    1085                 1090                 1095             


Lys Val  Asn Glu Cys Val Lys  Ser Gln Ser Ser Arg  Ile Asn Phe 
    1100                 1105                 1110             


Cys Gly  Asn Gly Asn His Ile  Ile Ser Leu Val Gln  Asn Ala Pro 
    1115                 1120                 1125             


Tyr Gly  Leu Tyr Phe Ile His  Phe Ser Tyr Val Pro  Thr Lys Tyr 
    1130                 1135                 1140             


Val Thr  Ala Arg Val Ser Pro  Gly Leu Cys Ile Ala  Gly Asp Arg 
    1145                 1150                 1155             


Gly Ile  Ala Pro Lys Ser Gly  Tyr Phe Val Asn Val  Asn Asn Thr 
    1160                 1165                 1170             


Trp Met  Tyr Thr Gly Ser Gly  Tyr Tyr Tyr Pro Glu  Pro Ile Thr 
    1175                 1180                 1185             


Glu Asn  Asn Val Val Val Met  Ser Thr Cys Ala Val  Asn Tyr Thr 
    1190                 1195                 1200             


Lys Ala  Pro Tyr Val Met Leu  Asn Thr Ser Ile Ser  Glu Leu Gln 
    1205                 1210                 1215             


Asp Phe  Lys Glu Glu Leu Asp  Gln Trp His Lys Asn  Gly Ser Gly 
    1220                 1225                 1230             


Gly Ser  Gly Asp Ile Ile Lys  Leu Leu Asn Glu Gln  Val Asn Lys 
    1235                 1240                 1245             


Glu Met  Gln Ser Ser Asn Leu  Tyr Met Ser Met Ser  Ser Trp Cys 
    1250                 1255                 1260             


Tyr Thr  His Ser Leu Asp Gly  Ala Gly Leu Phe Leu  Phe Asp His 
    1265                 1270                 1275             


Ala Ala  Glu Glu Tyr Glu His  Ala Lys Lys Leu Ile  Ile Phe Leu 
    1280                 1285                 1290             


Asn Glu  Asn Asn Val Pro Val  Gln Leu Thr Ser Ile  Ser Ala Pro 
    1295                 1300                 1305             


Glu His  Lys Phe Glu Gly Leu  Thr Gln Ile Phe Gln  Lys Ala Tyr 
    1310                 1315                 1320             


Glu His  Glu Gln His Ile Ser  Glu Ser Ile Asn Asn  Ile Val Asp 
    1325                 1330                 1335             


His Ala  Ile Lys Ser Lys Asp  His Ala Thr Phe Asn  Phe Leu Gln 
    1340                 1345                 1350             


Trp Tyr  Val Ala Glu Gln His  Glu Glu Glu Val Leu  Phe Lys Asp 
    1355                 1360                 1365             


Ile Leu  Asp Lys Ile Glu Leu  Ile Gly Asn Glu Asn  His Gly Leu 
    1370                 1375                 1380             


Tyr Leu  Ala Asp Gln Tyr Val  Lys Gly Ile Ala Lys  Ser Arg Lys 
    1385                 1390                 1395             


Ser Gly  Ser 
    1400     


<210> 257
<211> 1401
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 257
Ala Val Ile Gly Asp Leu Lys Cys Thr Ser Asp Asn Ile Asn Asp Lys 
1               5                   10                  15      


Asp Thr Gly Pro Pro Pro Ile Ser Thr Asp Thr Val Asp Val Thr Asn 
            20                  25                  30          


Gly Leu Gly Thr Tyr Tyr Val Leu Asp Arg Val Tyr Leu Asn Thr Thr 
        35                  40                  45              


Leu Phe Leu Asn Gly Tyr Tyr Pro Thr Ser Gly Ser Thr Tyr Arg Asn 
    50                  55                  60                  


Met Ala Leu Lys Gly Ser Val Leu Leu Ser Arg Leu Trp Phe Lys Pro 
65                  70                  75                  80  


Pro Phe Leu Ser Asp Phe Ile Asn Gly Ile Phe Ala Lys Val Lys Asn 
                85                  90                  95      


Thr Lys Val Ile Lys Asp Arg Val Met Tyr Ser Glu Phe Pro Ala Ile 
            100                 105                 110         


Thr Ile Gly Ser Thr Phe Val Asn Thr Ser Tyr Ser Val Val Val Gln 
        115                 120                 125             


Pro Arg Thr Ile Asn Ser Thr Gln Asp Gly Asp Asn Lys Leu Gln Gly 
    130                 135                 140                 


Leu Leu Glu Val Ser Val Cys Gln Tyr Asn Met Cys Glu Tyr Pro Gln 
145                 150                 155                 160 


Thr Ile Cys His Pro Asn Leu Gly Asn His Arg Lys Glu Leu Trp His 
                165                 170                 175     


Leu Asp Thr Gly Val Val Ser Cys Leu Tyr Lys Arg Asn Phe Thr Tyr 
            180                 185                 190         


Asp Val Asn Ala Asp Tyr Leu Tyr Phe His Phe Tyr Gln Glu Gly Gly 
        195                 200                 205             


Thr Phe Tyr Ala Tyr Phe Thr Asp Thr Gly Val Val Thr Lys Phe Leu 
    210                 215                 220                 


Phe Asn Val Tyr Leu Gly Met Ala Leu Ser His Tyr Tyr Val Met Pro 
225                 230                 235                 240 


Leu Thr Cys Asn Ser Lys Leu Thr Leu Glu Tyr Trp Val Thr Pro Leu 
                245                 250                 255     


Thr Ser Arg Gln Tyr Leu Leu Ala Phe Asn Gln Asp Gly Ile Ile Phe 
            260                 265                 270         


Asn Ala Val Asp Cys Met Ser Asp Phe Met Ser Glu Ile Lys Cys Lys 
        275                 280                 285             


Thr Gln Ser Ile Ala Pro Pro Thr Gly Val Tyr Glu Leu Asn Gly Tyr 
    290                 295                 300                 


Thr Val Gln Pro Ile Ala Asp Val Tyr Arg Arg Lys Pro Asn Leu Pro 
305                 310                 315                 320 


Asn Cys Asn Ile Glu Ala Trp Leu Asn Asp Lys Ser Val Pro Ser Pro 
                325                 330                 335     


Leu Asn Trp Glu Arg Lys Thr Phe Ser Asn Cys Asn Phe Asn Met Ser 
            340                 345                 350         


Ser Leu Met Ser Phe Ile Gln Ala Asp Ser Phe Thr Cys Asn Asn Ile 
        355                 360                 365             


Asp Ala Ala Lys Ile Tyr Gly Met Cys Phe Ser Ser Ile Thr Ile Asp 
    370                 375                 380                 


Lys Phe Ala Ile Pro Asn Gly Arg Lys Val Asp Leu Gln Leu Gly Asn 
385                 390                 395                 400 


Leu Gly Tyr Leu Gln Ser Phe Asn Tyr Arg Ile Asp Thr Thr Ala Thr 
                405                 410                 415     


Ser Cys Gln Leu Tyr Tyr Asn Leu Pro Ala Ala Asn Val Ser Val Ser 
            420                 425                 430         


Arg Phe Asn Pro Ser Thr Trp Asn Lys Arg Phe Gly Phe Ile Glu Asp 
        435                 440                 445             


Ser Val Phe Lys Pro Arg Pro Ala Gly Val Leu Thr Asn His Asp Val 
    450                 455                 460                 


Val Tyr Ala Gln His Cys Phe Lys Ala Pro Lys Asn Phe Cys Pro Cys 
465                 470                 475                 480 


Lys Leu Asn Gly Ser Cys Val Gly Ser Gly Pro Gly Lys Asn Asn Gly 
                485                 490                 495     


Ile Gly Thr Cys Pro Ala Gly Thr Asn Tyr Leu Thr Cys Asp Asn Leu 
            500                 505                 510         


Cys Thr Pro Asp Pro Ile Thr Phe Thr Gly Thr Tyr Lys Cys Pro Gln 
        515                 520                 525             


Thr Lys Ser Leu Val Gly Ile Gly Glu His Cys Ser Gly Leu Ala Val 
    530                 535                 540                 


Lys Ser Asp Tyr Cys Gly Gly Asn Ser Cys Thr Cys Arg Pro Gln Ala 
545                 550                 555                 560 


Phe Leu Gly Trp Ser Ala Asp Ser Cys Leu Gln Gly Asp Lys Cys Asn 
                565                 570                 575     


Ile Phe Ala Asn Phe Ile Leu His Asp Val Asn Ser Gly Leu Thr Cys 
            580                 585                 590         


Ser Thr Asp Leu Gln Lys Ala Asn Thr Asp Ile Ile Leu Gly Val Cys 
        595                 600                 605             


Val Asn Tyr Asp Leu Tyr Gly Ile Leu Gly Gln Gly Ile Phe Val Glu 
    610                 615                 620                 


Val Asn Ala Thr Tyr Tyr Asn Ser Trp Gln Asn Leu Leu Tyr Asp Ser 
625                 630                 635                 640 


Asn Gly Asn Leu Tyr Gly Phe Arg Asp Tyr Ile Thr Asn Arg Thr Phe 
                645                 650                 655     


Met Ile Arg Ser Cys Tyr Ser Gly Arg Val Ser Ala Ala Phe His Ala 
            660                 665                 670         


Asn Ser Ser Glu Pro Ala Leu Leu Phe Arg Asn Ile Lys Cys Asn Tyr 
        675                 680                 685             


Val Phe Asn Asn Ser Leu Thr Arg Gln Leu Gln Pro Ile Asn Tyr Phe 
    690                 695                 700                 


Asp Ser Tyr Leu Gly Cys Val Val Asn Ala Tyr Asn Ser Thr Ala Ile 
705                 710                 715                 720 


Ser Val Gln Thr Cys Asp Leu Thr Val Gly Ser Gly Tyr Cys Val Asp 
                725                 730                 735     


Tyr Ser Lys Asn Gly Gly Ser Gly Gly Ala Ile Thr Thr Gly Tyr Arg 
            740                 745                 750         


Phe Thr Asn Phe Glu Pro Phe Thr Val Asn Ser Val Asn Asp Ser Leu 
        755                 760                 765             


Glu Pro Val Gly Gly Leu Tyr Glu Ile Gln Ile Pro Ser Glu Phe Thr 
    770                 775                 780                 


Ile Gly Asn Met Val Glu Phe Ile Gln Thr Ser Ser Pro Lys Val Thr 
785                 790                 795                 800 


Ile Asp Cys Ala Ala Phe Val Cys Gly Asp Tyr Ala Ala Cys Lys Ser 
                805                 810                 815     


Gln Leu Val Glu Tyr Gly Ser Phe Cys Asp Asn Ile Asn Ala Ile Leu 
            820                 825                 830         


Thr Glu Val Asn Glu Leu Leu Asp Thr Thr Gln Leu Gln Val Ala Asn 
        835                 840                 845             


Ser Leu Met Asn Gly Val Thr Leu Ser Thr Lys Leu Lys Asp Gly Val 
    850                 855                 860                 


Asn Phe Asn Val Asp Asp Ile Asn Phe Ser Pro Val Leu Gly Cys Leu 
865                 870                 875                 880 


Gly Ser Glu Cys Ser Lys Ala Ser Ser Arg Ser Ala Ile Glu Asp Leu 
                885                 890                 895     


Leu Phe Asp Lys Val Lys Leu Ser Asp Val Gly Phe Val Glu Ala Tyr 
            900                 905                 910         


Asn Asn Cys Thr Gly Gly Ala Glu Ile Arg Asp Leu Ile Cys Val Gln 
        915                 920                 925             


Ser Tyr Lys Gly Ile Lys Val Leu Pro Pro Leu Leu Ser Glu Asn Gln 
    930                 935                 940                 


Phe Ser Gly Tyr Thr Leu Ala Ala Thr Ser Ala Ser Leu Phe Pro Pro 
945                 950                 955                 960 


Trp Thr Ala Ala Ala Gly Val Pro Phe Tyr Leu Asn Val Gln Tyr Arg 
                965                 970                 975     


Ile Asn Gly Leu Gly Val Thr Met Asp Val Leu Ser Gln Asn Gln Lys 
            980                 985                 990         


Leu Ile Ala Asn Ala Phe Asn Asn  Ala Leu Tyr Ala Ile  Gln Glu Gly 
        995                 1000                 1005             


Phe Asp  Ala Thr Asn Ser Ala  Leu Val Lys Ile Gln  Ala Val Val 
    1010                 1015                 1020             


Asn Ala  Asn Ala Glu Ala Leu  Asn Asn Leu Leu Gln  Gln Leu Ser 
    1025                 1030                 1035             


Asn Arg  Phe Gly Ala Ile Ser  Ala Ser Leu Gln Glu  Ile Leu Ser 
    1040                 1045                 1050             


Arg Leu  Asp Pro Pro Glu Ala  Glu Ala Gln Ile Asp  Arg Leu Ile 
    1055                 1060                 1065             


Asn Gly  Arg Leu Thr Ala Leu  Asn Ala Tyr Val Ser  Gln Gln Leu 
    1070                 1075                 1080             


Ser Asp  Ser Thr Leu Val Lys  Phe Ser Ala Ala Gln  Ala Met Glu 
    1085                 1090                 1095             


Lys Val  Asn Glu Cys Val Lys  Ser Gln Ser Ser Arg  Ile Asn Phe 
    1100                 1105                 1110             


Cys Gly  Asn Gly Asn His Ile  Ile Ser Leu Val Gln  Asn Ala Pro 
    1115                 1120                 1125             


Tyr Gly  Leu Tyr Phe Ile His  Phe Ser Tyr Val Pro  Thr Lys Tyr 
    1130                 1135                 1140             


Val Thr  Ala Arg Val Ser Pro  Gly Leu Cys Ile Ala  Gly Asp Arg 
    1145                 1150                 1155             


Gly Ile  Ala Pro Lys Ser Gly  Tyr Phe Val Asn Val  Asn Asn Thr 
    1160                 1165                 1170             


Trp Met  Tyr Thr Gly Ser Gly  Tyr Tyr Tyr Pro Glu  Pro Ile Thr 
    1175                 1180                 1185             


Glu Asn  Asn Val Val Val Met  Ser Thr Cys Ala Val  Asn Tyr Thr 
    1190                 1195                 1200             


Lys Ala  Pro Tyr Val Met Leu  Asn Thr Ser Ile Ser  Glu Leu Gln 
    1205                 1210                 1215             


Asp Phe  Lys Glu Glu Leu Asp  Gln Trp His Lys Gln  Gly Ser Gly 
    1220                 1225                 1230             


Gly Ser  Gly Asp Ile Ile Lys  Leu Leu Asn Glu Gln  Val Asn Lys 
    1235                 1240                 1245             


Glu Met  Gln Ser Ser Asn Leu  Tyr Met Ser Met Ser  Ser Trp Cys 
    1250                 1255                 1260             


Tyr Thr  His Ser Leu Asp Gly  Ala Gly Leu Phe Leu  Phe Asp His 
    1265                 1270                 1275             


Ala Ala  Glu Glu Tyr Glu His  Ala Lys Lys Leu Ile  Ile Phe Leu 
    1280                 1285                 1290             


Asn Glu  Asn Asn Val Pro Val  Gln Leu Thr Ser Ile  Ser Ala Pro 
    1295                 1300                 1305             


Glu His  Lys Phe Glu Gly Leu  Thr Gln Ile Phe Gln  Lys Ala Tyr 
    1310                 1315                 1320             


Glu His  Glu Gln His Ile Ser  Glu Ser Ile Asn Asn  Ile Val Asp 
    1325                 1330                 1335             


His Ala  Ile Lys Ser Lys Asp  His Ala Thr Phe Asn  Phe Leu Gln 
    1340                 1345                 1350             


Trp Tyr  Val Ala Glu Gln His  Glu Glu Glu Val Leu  Phe Lys Asp 
    1355                 1360                 1365             


Ile Leu  Asp Lys Ile Glu Leu  Ile Gly Asn Glu Asn  His Gly Leu 
    1370                 1375                 1380             


Tyr Leu  Ala Asp Gln Tyr Val  Lys Gly Ile Ala Lys  Ser Arg Lys 
    1385                 1390                 1395             


Ser Gly  Ser 
    1400     


<210> 258
<211> 1401
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 258
Ala Val Ile Gly Asp Leu Lys Cys Thr Ser Asp Asn Ile Asn Asp Lys 
1               5                   10                  15      


Asp Thr Gly Pro Pro Pro Ile Ser Thr Asp Thr Val Asp Val Thr Asn 
            20                  25                  30          


Gly Leu Gly Thr Tyr Tyr Val Leu Asp Arg Val Tyr Leu Asn Thr Thr 
        35                  40                  45              


Leu Phe Leu Asn Gly Tyr Tyr Pro Thr Ser Gly Ser Thr Tyr Arg Asn 
    50                  55                  60                  


Met Ala Leu Lys Gly Ser Val Leu Leu Ser Arg Leu Trp Phe Lys Pro 
65                  70                  75                  80  


Pro Phe Leu Ser Asp Phe Ile Asn Gly Ile Phe Ala Lys Val Lys Asn 
                85                  90                  95      


Thr Lys Val Ile Lys Asp Arg Val Met Tyr Ser Glu Phe Pro Ala Ile 
            100                 105                 110         


Thr Ile Gly Ser Thr Phe Val Asn Thr Ser Tyr Ser Val Val Val Gln 
        115                 120                 125             


Pro Arg Thr Ile Asn Ser Thr Gln Asp Gly Asp Asn Lys Leu Gln Gly 
    130                 135                 140                 


Leu Leu Glu Val Ser Val Cys Gln Tyr Asn Met Cys Glu Tyr Pro Gln 
145                 150                 155                 160 


Thr Ile Cys His Pro Asn Leu Gly Asn His Arg Lys Glu Leu Trp His 
                165                 170                 175     


Leu Asp Thr Gly Val Val Ser Cys Leu Tyr Lys Arg Asn Phe Thr Tyr 
            180                 185                 190         


Asp Val Asn Ala Asp Tyr Leu Tyr Phe His Phe Tyr Gln Glu Gly Gly 
        195                 200                 205             


Thr Phe Tyr Ala Tyr Phe Thr Asp Thr Gly Val Val Thr Lys Phe Leu 
    210                 215                 220                 


Phe Asn Val Tyr Leu Gly Met Ala Leu Ser His Tyr Tyr Val Met Pro 
225                 230                 235                 240 


Leu Thr Cys Asn Ser Lys Leu Thr Leu Glu Tyr Trp Val Thr Pro Leu 
                245                 250                 255     


Thr Ser Arg Gln Tyr Leu Leu Ala Phe Asn Gln Asp Gly Ile Ile Phe 
            260                 265                 270         


Asn Ala Val Asp Cys Met Ser Asp Phe Met Ser Glu Ile Lys Cys Lys 
        275                 280                 285             


Thr Gln Ser Ile Ala Pro Pro Thr Gly Val Tyr Glu Leu Asn Gly Tyr 
    290                 295                 300                 


Thr Val Gln Pro Ile Ala Asp Val Tyr Arg Arg Lys Pro Asn Leu Pro 
305                 310                 315                 320 


Asn Cys Asn Ile Glu Ala Trp Leu Asn Asp Lys Ser Val Pro Ser Pro 
                325                 330                 335     


Leu Asn Trp Glu Arg Lys Thr Phe Ser Asn Cys Asn Phe Asn Met Ser 
            340                 345                 350         


Ser Leu Met Ser Phe Ile Gln Ala Asp Ser Phe Thr Cys Asn Asn Ile 
        355                 360                 365             


Asp Ala Ala Lys Ile Tyr Gly Met Cys Phe Ser Ser Ile Thr Ile Asp 
    370                 375                 380                 


Lys Phe Ala Ile Pro Asn Gly Arg Lys Val Asp Leu Gln Leu Gly Asn 
385                 390                 395                 400 


Leu Gly Tyr Leu Gln Ser Phe Asn Tyr Arg Ile Asp Thr Thr Ala Thr 
                405                 410                 415     


Ser Cys Gln Leu Tyr Tyr Asn Leu Pro Ala Ala Asn Val Ser Val Ser 
            420                 425                 430         


Arg Phe Asn Pro Ser Thr Trp Asn Lys Arg Phe Gly Phe Ile Glu Asp 
        435                 440                 445             


Ser Val Phe Lys Pro Arg Pro Ala Gly Val Leu Thr Asn His Asp Val 
    450                 455                 460                 


Val Tyr Ala Gln His Cys Phe Lys Ala Pro Lys Asn Phe Cys Pro Cys 
465                 470                 475                 480 


Lys Leu Asn Gly Ser Cys Val Gly Ser Gly Pro Gly Lys Asn Asn Gly 
                485                 490                 495     


Ile Gly Thr Cys Pro Ala Gly Thr Asn Tyr Leu Thr Cys Asp Asn Leu 
            500                 505                 510         


Cys Thr Pro Asp Pro Ile Thr Phe Thr Gly Thr Tyr Lys Cys Pro Gln 
        515                 520                 525             


Thr Lys Ser Leu Val Gly Ile Gly Glu His Cys Ser Gly Leu Ala Val 
    530                 535                 540                 


Lys Ser Asp Tyr Cys Gly Gly Asn Ser Cys Thr Cys Arg Pro Gln Ala 
545                 550                 555                 560 


Phe Leu Gly Trp Ser Ala Asp Ser Cys Leu Gln Gly Asp Lys Cys Asn 
                565                 570                 575     


Ile Phe Ala Asn Phe Ile Leu His Asp Val Asn Ser Gly Leu Thr Cys 
            580                 585                 590         


Ser Thr Asp Leu Gln Lys Ala Asn Thr Asp Ile Ile Leu Gly Val Cys 
        595                 600                 605             


Val Asn Tyr Asp Leu Tyr Gly Ile Leu Gly Gln Gly Ile Phe Val Glu 
    610                 615                 620                 


Val Asn Ala Thr Tyr Tyr Asn Ser Trp Gln Asn Leu Leu Tyr Asp Ser 
625                 630                 635                 640 


Asn Gly Asn Leu Tyr Gly Phe Arg Asp Tyr Ile Thr Asn Arg Thr Phe 
                645                 650                 655     


Met Ile Arg Ser Cys Tyr Ser Gly Arg Val Ser Ala Ala Phe His Ala 
            660                 665                 670         


Asn Ser Ser Glu Pro Ala Leu Leu Phe Arg Asn Ile Lys Cys Asn Tyr 
        675                 680                 685             


Val Phe Asn Asn Ser Leu Thr Arg Gln Leu Gln Pro Ile Asn Tyr Phe 
    690                 695                 700                 


Asp Ser Tyr Leu Gly Cys Val Val Asn Ala Tyr Asn Ser Thr Ala Ile 
705                 710                 715                 720 


Ser Val Gln Thr Cys Asp Leu Thr Val Gly Ser Gly Tyr Cys Val Asp 
                725                 730                 735     


Tyr Ser Lys Asn Gly Gly Ser Gly Gly Ala Ile Thr Thr Gly Tyr Arg 
            740                 745                 750         


Phe Thr Asn Phe Glu Pro Phe Thr Val Asn Ser Val Asn Asp Ser Leu 
        755                 760                 765             


Glu Pro Val Gly Gly Leu Tyr Glu Ile Gln Ile Pro Ser Glu Phe Thr 
    770                 775                 780                 


Ile Gly Asn Met Val Glu Phe Ile Gln Thr Ser Ser Pro Lys Val Thr 
785                 790                 795                 800 


Ile Asp Cys Ala Ala Phe Val Cys Gly Asp Tyr Ala Ala Cys Lys Ser 
                805                 810                 815     


Gln Leu Val Glu Tyr Gly Ser Phe Cys Asp Asn Ile Asn Ala Ile Leu 
            820                 825                 830         


Thr Glu Val Asn Glu Leu Leu Asp Thr Thr Gln Leu Gln Val Ala Asn 
        835                 840                 845             


Ser Leu Met Asn Gly Val Thr Leu Ser Thr Lys Leu Lys Asp Gly Val 
    850                 855                 860                 


Asn Phe Asn Val Asp Asp Ile Asn Phe Ser Pro Val Leu Gly Cys Leu 
865                 870                 875                 880 


Gly Ser Glu Cys Ser Lys Ala Ser Ser Arg Ser Ala Ile Glu Asp Leu 
                885                 890                 895     


Leu Phe Asp Lys Val Lys Leu Ser Asp Val Gly Phe Val Glu Ala Tyr 
            900                 905                 910         


Asn Asn Cys Thr Gly Gly Ala Glu Ile Arg Asp Leu Ile Cys Val Gln 
        915                 920                 925             


Ser Tyr Lys Gly Ile Lys Val Leu Pro Pro Leu Leu Ser Glu Asn Gln 
    930                 935                 940                 


Phe Ser Gly Tyr Thr Leu Ala Ala Thr Ser Ala Ser Leu Phe Pro Pro 
945                 950                 955                 960 


Trp Thr Ala Ala Ala Gly Val Pro Phe Tyr Leu Asn Val Gln Tyr Arg 
                965                 970                 975     


Ile Asn Gly Leu Gly Val Thr Met Asp Val Leu Ser Gln Asn Gln Lys 
            980                 985                 990         


Leu Ile Ala Asn Ala Phe Asn Asn  Ala Leu Tyr Ala Ile  Gln Glu Gly 
        995                 1000                 1005             


Phe Asp  Ala Thr Asn Ser Ala  Leu Val Lys Ile Gln  Ala Val Val 
    1010                 1015                 1020             


Asn Ala  Asn Ala Glu Ala Leu  Asn Asn Leu Leu Gln  Gln Leu Ser 
    1025                 1030                 1035             


Asn Arg  Phe Gly Ala Ile Ser  Ala Ser Leu Gln Glu  Ile Leu Ser 
    1040                 1045                 1050             


Arg Leu  Asp Pro Pro Glu Ala  Glu Ala Gln Ile Asp  Arg Leu Ile 
    1055                 1060                 1065             


Asn Gly  Arg Leu Thr Ala Leu  Asn Ala Tyr Val Ser  Gln Gln Leu 
    1070                 1075                 1080             


Ser Asp  Ser Thr Leu Val Lys  Phe Ser Ala Ala Gln  Ala Met Glu 
    1085                 1090                 1095             


Lys Val  Asn Glu Cys Val Lys  Ser Gln Ser Ser Arg  Ile Asn Phe 
    1100                 1105                 1110             


Cys Gly  Asn Gly Asn His Ile  Ile Ser Leu Val Gln  Asn Ala Pro 
    1115                 1120                 1125             


Tyr Gly  Leu Tyr Phe Ile His  Phe Ser Tyr Val Pro  Thr Lys Tyr 
    1130                 1135                 1140             


Val Thr  Ala Arg Val Ser Pro  Gly Leu Cys Ile Ala  Gly Asp Arg 
    1145                 1150                 1155             


Gly Ile  Ala Pro Lys Ser Gly  Tyr Phe Val Asn Val  Asn Asn Thr 
    1160                 1165                 1170             


Trp Met  Tyr Thr Gly Ser Gly  Tyr Tyr Tyr Pro Glu  Pro Ile Thr 
    1175                 1180                 1185             


Glu Asn  Asn Val Val Val Met  Ser Thr Cys Ala Val  Asn Tyr Thr 
    1190                 1195                 1200             


Lys Ala  Pro Tyr Val Met Leu  Asn Thr Leu Gln Ser  Asn Leu Gln 
    1205                 1210                 1215             


Asp Ile  Lys Glu Glu Leu Asp  Gln Ile His Lys Asn  Gly Ser Gly 
    1220                 1225                 1230             


Gly Ser  Gly Asp Ile Ile Lys  Leu Leu Asn Glu Gln  Val Asn Lys 
    1235                 1240                 1245             


Glu Met  Gln Ser Ser Asn Leu  Tyr Met Ser Met Ser  Ser Trp Cys 
    1250                 1255                 1260             


Tyr Thr  His Ser Leu Asp Gly  Ala Gly Leu Phe Leu  Phe Asp His 
    1265                 1270                 1275             


Ala Ala  Glu Glu Tyr Glu His  Ala Lys Lys Leu Ile  Ile Phe Leu 
    1280                 1285                 1290             


Asn Glu  Asn Asn Val Pro Val  Gln Leu Thr Ser Ile  Ser Ala Pro 
    1295                 1300                 1305             


Glu His  Lys Phe Glu Gly Leu  Thr Gln Ile Phe Gln  Lys Ala Tyr 
    1310                 1315                 1320             


Glu His  Glu Gln His Ile Ser  Glu Ser Ile Asn Asn  Ile Val Asp 
    1325                 1330                 1335             


His Ala  Ile Lys Ser Lys Asp  His Ala Thr Phe Asn  Phe Leu Gln 
    1340                 1345                 1350             


Trp Tyr  Val Ala Glu Gln His  Glu Glu Glu Val Leu  Phe Lys Asp 
    1355                 1360                 1365             


Ile Leu  Asp Lys Ile Glu Leu  Ile Gly Asn Glu Asn  His Gly Leu 
    1370                 1375                 1380             


Tyr Leu  Ala Asp Gln Tyr Val  Lys Gly Ile Ala Lys  Ser Arg Lys 
    1385                 1390                 1395             


Ser Gly  Ser 
    1400     


<210> 259
<211> 1401
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 259
Ala Val Ile Gly Asp Leu Lys Cys Thr Ser Asp Asn Ile Asn Asp Lys 
1               5                   10                  15      


Asp Thr Gly Pro Pro Pro Ile Ser Thr Asp Thr Val Asp Val Thr Asn 
            20                  25                  30          


Gly Leu Gly Thr Tyr Tyr Val Leu Asp Arg Val Tyr Leu Asn Thr Thr 
        35                  40                  45              


Leu Phe Leu Asn Gly Tyr Tyr Pro Thr Ser Gly Ser Thr Tyr Arg Asn 
    50                  55                  60                  


Met Ala Leu Lys Gly Ser Val Leu Leu Ser Arg Leu Trp Phe Lys Pro 
65                  70                  75                  80  


Pro Phe Leu Ser Asp Phe Ile Asn Gly Ile Phe Ala Lys Val Lys Asn 
                85                  90                  95      


Thr Lys Val Ile Lys Asp Arg Val Met Tyr Ser Glu Phe Pro Ala Ile 
            100                 105                 110         


Thr Ile Gly Ser Thr Phe Val Asn Thr Ser Tyr Ser Val Val Val Gln 
        115                 120                 125             


Pro Arg Thr Ile Asn Ser Thr Gln Asp Gly Asp Asn Lys Leu Gln Gly 
    130                 135                 140                 


Leu Leu Glu Val Ser Val Cys Gln Tyr Asn Met Cys Glu Tyr Pro Gln 
145                 150                 155                 160 


Thr Ile Cys His Pro Asn Leu Gly Asn His Arg Lys Glu Leu Trp His 
                165                 170                 175     


Leu Asp Thr Gly Val Val Ser Cys Leu Tyr Lys Arg Asn Phe Thr Tyr 
            180                 185                 190         


Asp Val Asn Ala Asp Tyr Leu Tyr Phe His Phe Tyr Gln Glu Gly Gly 
        195                 200                 205             


Thr Phe Tyr Ala Tyr Phe Thr Asp Thr Gly Val Val Thr Lys Phe Leu 
    210                 215                 220                 


Phe Asn Val Tyr Leu Gly Met Ala Leu Ser His Tyr Tyr Val Met Pro 
225                 230                 235                 240 


Leu Thr Cys Asn Ser Lys Leu Thr Leu Glu Tyr Trp Val Thr Pro Leu 
                245                 250                 255     


Thr Ser Arg Gln Tyr Leu Leu Ala Phe Asn Gln Asp Gly Ile Ile Phe 
            260                 265                 270         


Asn Ala Val Asp Cys Met Ser Asp Phe Met Ser Glu Ile Lys Cys Lys 
        275                 280                 285             


Thr Gln Ser Ile Ala Pro Pro Thr Gly Val Tyr Glu Leu Asn Gly Tyr 
    290                 295                 300                 


Thr Val Gln Pro Ile Ala Asp Val Tyr Arg Arg Lys Pro Asn Leu Pro 
305                 310                 315                 320 


Asn Cys Asn Ile Glu Ala Trp Leu Asn Asp Lys Ser Val Pro Ser Pro 
                325                 330                 335     


Leu Asn Trp Glu Arg Lys Thr Phe Ser Asn Cys Asn Phe Asn Met Ser 
            340                 345                 350         


Ser Leu Met Ser Phe Ile Gln Ala Asp Ser Phe Thr Cys Asn Asn Ile 
        355                 360                 365             


Asp Ala Ala Lys Ile Tyr Gly Met Cys Phe Ser Ser Ile Thr Ile Asp 
    370                 375                 380                 


Lys Phe Ala Ile Pro Asn Gly Arg Lys Val Asp Leu Gln Leu Gly Asn 
385                 390                 395                 400 


Leu Gly Tyr Leu Gln Ser Phe Asn Tyr Arg Ile Asp Thr Thr Ala Thr 
                405                 410                 415     


Ser Cys Gln Leu Tyr Tyr Asn Leu Pro Ala Ala Asn Val Ser Val Ser 
            420                 425                 430         


Arg Phe Asn Pro Ser Thr Trp Asn Lys Arg Phe Gly Phe Ile Glu Asp 
        435                 440                 445             


Ser Val Phe Lys Pro Arg Pro Ala Gly Val Leu Thr Asn His Asp Val 
    450                 455                 460                 


Val Tyr Ala Gln His Cys Phe Lys Ala Pro Lys Asn Phe Cys Pro Cys 
465                 470                 475                 480 


Lys Leu Asn Gly Ser Cys Val Gly Ser Gly Pro Gly Lys Asn Asn Gly 
                485                 490                 495     


Ile Gly Thr Cys Pro Ala Gly Thr Asn Tyr Leu Thr Cys Asp Asn Leu 
            500                 505                 510         


Cys Thr Pro Asp Pro Ile Thr Phe Thr Gly Thr Tyr Lys Cys Pro Gln 
        515                 520                 525             


Thr Lys Ser Leu Val Gly Ile Gly Glu His Cys Ser Gly Leu Ala Val 
    530                 535                 540                 


Lys Ser Asp Tyr Cys Gly Gly Asn Ser Cys Thr Cys Arg Pro Gln Ala 
545                 550                 555                 560 


Phe Leu Gly Trp Ser Ala Asp Ser Cys Leu Gln Gly Asp Lys Cys Asn 
                565                 570                 575     


Ile Phe Ala Asn Phe Ile Leu His Asp Val Asn Ser Gly Leu Thr Cys 
            580                 585                 590         


Ser Thr Asp Leu Gln Lys Ala Asn Thr Asp Ile Ile Leu Gly Val Cys 
        595                 600                 605             


Val Asn Tyr Asp Leu Tyr Gly Ile Leu Gly Gln Gly Ile Phe Val Glu 
    610                 615                 620                 


Val Asn Ala Thr Tyr Tyr Asn Ser Trp Gln Asn Leu Leu Tyr Asp Ser 
625                 630                 635                 640 


Asn Gly Asn Leu Tyr Gly Phe Arg Asp Tyr Ile Thr Asn Arg Thr Phe 
                645                 650                 655     


Met Ile Arg Ser Cys Tyr Ser Gly Arg Val Ser Ala Ala Phe His Ala 
            660                 665                 670         


Asn Ser Ser Glu Pro Ala Leu Leu Phe Arg Asn Ile Lys Cys Asn Tyr 
        675                 680                 685             


Val Phe Asn Asn Ser Leu Thr Arg Gln Leu Gln Pro Ile Asn Tyr Phe 
    690                 695                 700                 


Asp Ser Tyr Leu Gly Cys Val Val Asn Ala Tyr Asn Ser Thr Ala Ile 
705                 710                 715                 720 


Ser Val Gln Thr Cys Asp Leu Thr Val Gly Ser Gly Tyr Cys Val Asp 
                725                 730                 735     


Tyr Ser Lys Asn Gly Gly Ser Gly Gly Ala Ile Thr Thr Gly Tyr Arg 
            740                 745                 750         


Phe Thr Asn Phe Glu Pro Phe Thr Val Asn Ser Val Asn Asp Ser Leu 
        755                 760                 765             


Glu Pro Val Gly Gly Leu Tyr Glu Ile Gln Ile Pro Ser Glu Phe Thr 
    770                 775                 780                 


Ile Gly Asn Met Val Glu Phe Ile Gln Thr Ser Ser Pro Lys Val Thr 
785                 790                 795                 800 


Ile Asp Cys Ala Ala Phe Val Cys Gly Asp Tyr Ala Ala Cys Lys Ser 
                805                 810                 815     


Gln Leu Val Glu Tyr Gly Ser Phe Cys Asp Asn Ile Asn Ala Ile Leu 
            820                 825                 830         


Thr Glu Val Asn Glu Leu Leu Asp Thr Thr Gln Leu Gln Val Ala Asn 
        835                 840                 845             


Ser Leu Met Asn Gly Val Thr Leu Ser Thr Lys Leu Lys Asp Gly Val 
    850                 855                 860                 


Asn Phe Asn Val Asp Asp Ile Asn Phe Ser Pro Val Leu Gly Cys Leu 
865                 870                 875                 880 


Gly Ser Glu Cys Ser Lys Ala Ser Ser Arg Ser Ala Ile Glu Asp Leu 
                885                 890                 895     


Leu Phe Asp Lys Val Lys Leu Ser Asp Val Gly Phe Val Glu Ala Tyr 
            900                 905                 910         


Asn Asn Cys Thr Gly Gly Ala Glu Ile Arg Asp Leu Ile Cys Val Gln 
        915                 920                 925             


Ser Tyr Lys Gly Ile Lys Val Leu Pro Pro Leu Leu Ser Glu Asn Gln 
    930                 935                 940                 


Phe Ser Gly Tyr Thr Leu Ala Ala Thr Ser Ala Ser Leu Phe Pro Pro 
945                 950                 955                 960 


Trp Thr Ala Ala Ala Gly Val Pro Phe Tyr Leu Asn Val Gln Tyr Arg 
                965                 970                 975     


Ile Asn Gly Leu Gly Val Thr Met Asp Val Leu Ser Gln Asn Gln Lys 
            980                 985                 990         


Leu Ile Ala Asn Ala Phe Asn Asn  Ala Leu Tyr Ala Ile  Gln Glu Gly 
        995                 1000                 1005             


Phe Asp  Ala Thr Asn Ser Ala  Leu Val Lys Ile Gln  Ala Val Val 
    1010                 1015                 1020             


Asn Ala  Asn Ala Glu Ala Leu  Asn Asn Leu Leu Gln  Gln Leu Ser 
    1025                 1030                 1035             


Asn Arg  Phe Gly Ala Ile Ser  Ala Ser Leu Gln Glu  Ile Leu Ser 
    1040                 1045                 1050             


Arg Leu  Asp Pro Pro Glu Ala  Glu Ala Gln Ile Asp  Arg Leu Ile 
    1055                 1060                 1065             


Asn Gly  Arg Leu Thr Ala Leu  Asn Ala Tyr Val Ser  Gln Gln Leu 
    1070                 1075                 1080             


Ser Asp  Ser Thr Leu Val Lys  Phe Ser Ala Ala Gln  Ala Met Glu 
    1085                 1090                 1095             


Lys Val  Asn Glu Cys Val Lys  Ser Gln Ser Ser Arg  Ile Asn Phe 
    1100                 1105                 1110             


Cys Gly  Asn Gly Asn His Ile  Ile Ser Leu Val Gln  Asn Ala Pro 
    1115                 1120                 1125             


Tyr Gly  Leu Tyr Phe Ile His  Phe Ser Tyr Val Pro  Thr Lys Tyr 
    1130                 1135                 1140             


Val Thr  Ala Arg Val Ser Pro  Gly Leu Cys Ile Ala  Gly Asp Arg 
    1145                 1150                 1155             


Gly Ile  Ala Pro Lys Ser Gly  Tyr Phe Val Asn Val  Asn Asn Thr 
    1160                 1165                 1170             


Trp Met  Tyr Thr Gly Ser Gly  Tyr Tyr Tyr Pro Glu  Pro Ile Thr 
    1175                 1180                 1185             


Glu Asn  Asn Val Val Val Met  Ser Thr Cys Ala Val  Asn Tyr Thr 
    1190                 1195                 1200             


Lys Ala  Pro Tyr Val Met Leu  Asn Thr Leu Gln Ser  Asn Leu Gln 
    1205                 1210                 1215             


Asp Ile  Lys Glu Glu Leu Asp  Gln Ile His Lys Gln  Gly Ser Gly 
    1220                 1225                 1230             


Gly Ser  Gly Asp Ile Ile Lys  Leu Leu Asn Glu Gln  Val Asn Lys 
    1235                 1240                 1245             


Glu Met  Gln Ser Ser Asn Leu  Tyr Met Ser Met Ser  Ser Trp Cys 
    1250                 1255                 1260             


Tyr Thr  His Ser Leu Asp Gly  Ala Gly Leu Phe Leu  Phe Asp His 
    1265                 1270                 1275             


Ala Ala  Glu Glu Tyr Glu His  Ala Lys Lys Leu Ile  Ile Phe Leu 
    1280                 1285                 1290             


Asn Glu  Asn Asn Val Pro Val  Gln Leu Thr Ser Ile  Ser Ala Pro 
    1295                 1300                 1305             


Glu His  Lys Phe Glu Gly Leu  Thr Gln Ile Phe Gln  Lys Ala Tyr 
    1310                 1315                 1320             


Glu His  Glu Gln His Ile Ser  Glu Ser Ile Asn Asn  Ile Val Asp 
    1325                 1330                 1335             


His Ala  Ile Lys Ser Lys Asp  His Ala Thr Phe Asn  Phe Leu Gln 
    1340                 1345                 1350             


Trp Tyr  Val Ala Glu Gln His  Glu Glu Glu Val Leu  Phe Lys Asp 
    1355                 1360                 1365             


Ile Leu  Asp Lys Ile Glu Leu  Ile Gly Asn Glu Asn  His Gly Leu 
    1370                 1375                 1380             


Tyr Leu  Ala Asp Gln Tyr Val  Lys Gly Ile Ala Lys  Ser Arg Lys 
    1385                 1390                 1395             


Ser Gly  Ser 
    1400     


<210> 260
<211> 1401
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 260
Ala Val Ile Gly Asp Leu Lys Cys Thr Ser Asp Asn Ile Asn Asp Lys 
1               5                   10                  15      


Asp Thr Gly Pro Pro Pro Ile Ser Thr Asp Thr Val Asp Val Thr Asn 
            20                  25                  30          


Gly Leu Gly Thr Tyr Tyr Val Leu Asp Arg Val Tyr Leu Asn Thr Thr 
        35                  40                  45              


Leu Phe Leu Asn Gly Tyr Tyr Pro Thr Ser Gly Ser Thr Tyr Arg Asn 
    50                  55                  60                  


Met Ala Leu Lys Gly Ser Val Leu Leu Ser Arg Leu Trp Phe Lys Pro 
65                  70                  75                  80  


Pro Phe Leu Ser Asp Phe Ile Asn Gly Ile Phe Ala Lys Val Lys Asn 
                85                  90                  95      


Thr Lys Val Ile Lys Asp Arg Val Met Tyr Ser Glu Phe Pro Ala Ile 
            100                 105                 110         


Thr Ile Gly Ser Thr Phe Val Asn Thr Ser Tyr Ser Val Val Val Gln 
        115                 120                 125             


Pro Arg Thr Ile Asn Ser Thr Gln Asp Gly Asp Asn Lys Leu Gln Gly 
    130                 135                 140                 


Leu Leu Glu Val Ser Val Cys Gln Tyr Asn Met Cys Glu Tyr Pro Gln 
145                 150                 155                 160 


Thr Ile Cys His Pro Asn Leu Gly Asn His Arg Lys Glu Leu Trp His 
                165                 170                 175     


Leu Asp Thr Gly Val Val Ser Cys Leu Tyr Lys Arg Asn Phe Thr Tyr 
            180                 185                 190         


Asp Val Asn Ala Asp Tyr Leu Tyr Phe His Phe Tyr Gln Glu Gly Gly 
        195                 200                 205             


Thr Phe Tyr Ala Tyr Phe Thr Asp Thr Gly Val Val Thr Lys Phe Leu 
    210                 215                 220                 


Phe Asn Val Tyr Leu Gly Met Ala Leu Ser His Tyr Tyr Val Met Pro 
225                 230                 235                 240 


Leu Thr Cys Asn Ser Lys Leu Thr Leu Glu Tyr Trp Val Thr Pro Leu 
                245                 250                 255     


Thr Ser Arg Gln Tyr Leu Leu Ala Phe Asn Gln Asp Gly Ile Ile Phe 
            260                 265                 270         


Asn Ala Val Asp Cys Met Ser Asp Phe Met Ser Glu Ile Lys Cys Lys 
        275                 280                 285             


Thr Gln Ser Ile Ala Pro Pro Thr Gly Val Tyr Glu Leu Asn Gly Tyr 
    290                 295                 300                 


Thr Val Gln Pro Ile Ala Asp Val Tyr Arg Arg Lys Pro Asn Leu Pro 
305                 310                 315                 320 


Asn Cys Asn Ile Glu Ala Trp Leu Asn Asp Lys Ser Val Pro Ser Pro 
                325                 330                 335     


Leu Asn Trp Glu Arg Lys Thr Phe Ser Asn Cys Asn Phe Asn Met Ser 
            340                 345                 350         


Ser Leu Met Ser Phe Ile Gln Ala Asp Ser Phe Thr Cys Asn Asn Ile 
        355                 360                 365             


Asp Ala Ala Lys Ile Tyr Gly Met Cys Phe Ser Ser Ile Thr Ile Asp 
    370                 375                 380                 


Lys Phe Ala Ile Pro Asn Gly Arg Lys Val Asp Leu Gln Leu Gly Asn 
385                 390                 395                 400 


Leu Gly Tyr Leu Gln Ser Phe Asn Tyr Arg Ile Asp Thr Thr Ala Thr 
                405                 410                 415     


Ser Cys Gln Leu Tyr Tyr Asn Leu Pro Ala Ala Asn Val Ser Val Ser 
            420                 425                 430         


Arg Phe Asn Pro Ser Thr Trp Asn Lys Arg Phe Gly Phe Ile Glu Asp 
        435                 440                 445             


Ser Val Phe Lys Pro Arg Pro Ala Gly Val Leu Thr Asn His Asp Val 
    450                 455                 460                 


Val Tyr Ala Gln His Cys Phe Lys Ala Pro Lys Asn Phe Cys Pro Cys 
465                 470                 475                 480 


Lys Leu Asn Gly Ser Cys Val Gly Ser Gly Pro Gly Lys Asn Asn Gly 
                485                 490                 495     


Ile Gly Thr Cys Pro Ala Gly Thr Asn Tyr Leu Thr Cys Asp Asn Leu 
            500                 505                 510         


Cys Thr Pro Asp Pro Ile Thr Phe Thr Gly Thr Tyr Lys Cys Pro Gln 
        515                 520                 525             


Thr Lys Ser Leu Val Gly Ile Gly Glu His Cys Ser Gly Leu Ala Val 
    530                 535                 540                 


Lys Ser Asp Tyr Cys Gly Gly Asn Ser Cys Thr Cys Arg Pro Gln Ala 
545                 550                 555                 560 


Phe Leu Gly Trp Ser Ala Asp Ser Cys Leu Gln Gly Asp Lys Cys Asn 
                565                 570                 575     


Ile Phe Ala Asn Phe Ile Leu His Asp Val Asn Ser Gly Leu Thr Cys 
            580                 585                 590         


Ser Thr Asp Leu Gln Lys Ala Asn Thr Asp Ile Ile Leu Gly Val Cys 
        595                 600                 605             


Val Asn Tyr Asp Leu Tyr Gly Ile Leu Gly Gln Gly Ile Phe Val Glu 
    610                 615                 620                 


Val Asn Ala Thr Tyr Tyr Asn Ser Trp Gln Asn Leu Leu Tyr Asp Ser 
625                 630                 635                 640 


Asn Gly Asn Leu Tyr Gly Phe Arg Asp Tyr Ile Thr Asn Arg Thr Phe 
                645                 650                 655     


Met Ile Arg Ser Cys Tyr Ser Gly Arg Val Ser Ala Ala Phe His Ala 
            660                 665                 670         


Asn Ser Ser Glu Pro Ala Leu Leu Phe Arg Asn Ile Lys Cys Asn Tyr 
        675                 680                 685             


Val Phe Asn Asn Ser Leu Thr Arg Gln Leu Gln Pro Ile Asn Tyr Phe 
    690                 695                 700                 


Asp Ser Tyr Leu Gly Cys Val Val Asn Ala Tyr Asn Ser Thr Ala Ile 
705                 710                 715                 720 


Ser Val Gln Thr Cys Asp Leu Thr Val Gly Ser Gly Tyr Cys Val Asp 
                725                 730                 735     


Tyr Ser Lys Asn Gly Gly Ser Gly Gly Ala Ile Thr Thr Gly Tyr Arg 
            740                 745                 750         


Phe Thr Asn Phe Glu Pro Phe Thr Val Asn Ser Val Asn Asp Ser Leu 
        755                 760                 765             


Glu Pro Val Gly Gly Leu Tyr Glu Ile Gln Ile Pro Ser Glu Phe Thr 
    770                 775                 780                 


Ile Gly Asn Met Val Glu Phe Ile Gln Thr Ser Ser Pro Lys Val Thr 
785                 790                 795                 800 


Ile Asp Cys Ala Ala Phe Val Cys Gly Asp Tyr Ala Ala Cys Lys Ser 
                805                 810                 815     


Gln Leu Val Glu Tyr Gly Ser Phe Cys Asp Asn Ile Asn Ala Ile Leu 
            820                 825                 830         


Thr Glu Val Asn Glu Leu Leu Asp Thr Thr Gln Leu Gln Val Ala Asn 
        835                 840                 845             


Ser Leu Met Asn Gly Val Thr Leu Ser Thr Lys Leu Lys Asp Gly Val 
    850                 855                 860                 


Asn Phe Asn Val Asp Asp Ile Asn Phe Ser Pro Val Leu Gly Cys Leu 
865                 870                 875                 880 


Gly Ser Glu Cys Ser Lys Ala Ser Ser Arg Ser Ala Ile Glu Asp Leu 
                885                 890                 895     


Leu Phe Asp Lys Val Lys Leu Ser Asp Val Gly Phe Val Glu Ala Tyr 
            900                 905                 910         


Asn Asn Cys Thr Gly Gly Ala Glu Ile Arg Asp Leu Ile Cys Val Gln 
        915                 920                 925             


Ser Tyr Lys Gly Ile Lys Val Leu Pro Pro Leu Leu Ser Glu Asn Gln 
    930                 935                 940                 


Phe Ser Gly Tyr Thr Leu Ala Ala Thr Ser Ala Ser Leu Phe Pro Pro 
945                 950                 955                 960 


Trp Thr Ala Ala Ala Gly Val Pro Phe Tyr Leu Asn Val Gln Tyr Arg 
                965                 970                 975     


Ile Asn Gly Leu Gly Val Thr Met Asp Val Leu Ser Gln Asn Gln Lys 
            980                 985                 990         


Leu Ile Ala Asn Ala Phe Asn Asn  Ala Leu Tyr Ala Ile  Gln Glu Gly 
        995                 1000                 1005             


Phe Asp  Ala Thr Asn Ser Ala  Leu Val Lys Ile Gln  Ala Val Val 
    1010                 1015                 1020             


Asn Ala  Asn Ala Glu Ala Leu  Asn Asn Leu Leu Gln  Gln Leu Ser 
    1025                 1030                 1035             


Asn Arg  Phe Gly Ala Ile Ser  Ala Ser Leu Gln Glu  Ile Leu Ser 
    1040                 1045                 1050             


Arg Leu  Asp Pro Pro Glu Ala  Glu Ala Gln Ile Asp  Arg Leu Ile 
    1055                 1060                 1065             


Asn Gly  Arg Leu Thr Ala Leu  Asn Ala Tyr Val Ser  Gln Gln Leu 
    1070                 1075                 1080             


Ser Asp  Ser Thr Leu Val Lys  Phe Ser Ala Ala Gln  Ala Met Glu 
    1085                 1090                 1095             


Lys Val  Asn Glu Cys Val Lys  Ser Gln Ser Ser Arg  Ile Asn Phe 
    1100                 1105                 1110             


Cys Gly  Asn Gly Asn His Ile  Ile Ser Leu Val Gln  Asn Ala Pro 
    1115                 1120                 1125             


Tyr Gly  Leu Tyr Phe Ile His  Phe Ser Tyr Val Pro  Thr Lys Tyr 
    1130                 1135                 1140             


Val Thr  Ala Arg Val Ser Pro  Gly Leu Cys Ile Ala  Gly Asp Arg 
    1145                 1150                 1155             


Gly Ile  Ala Pro Lys Ser Gly  Tyr Phe Val Asn Val  Asn Asn Thr 
    1160                 1165                 1170             


Trp Met  Tyr Thr Gly Ser Gly  Tyr Tyr Tyr Pro Glu  Pro Ile Thr 
    1175                 1180                 1185             


Glu Asn  Asn Val Val Val Met  Ser Thr Cys Ala Val  Asn Tyr Thr 
    1190                 1195                 1200             


Lys Ala  Pro Tyr Val Met Leu  Asn Thr Leu Gln Ser  Asn Leu Gln 
    1205                 1210                 1215             


Asp Leu  Lys Glu Glu Leu Asp  Gln Leu His Lys Asn  Gly Ser Gly 
    1220                 1225                 1230             


Gly Ser  Gly Asp Ile Ile Lys  Leu Leu Asn Glu Gln  Val Asn Lys 
    1235                 1240                 1245             


Glu Met  Gln Ser Ser Asn Leu  Tyr Met Ser Met Ser  Ser Trp Cys 
    1250                 1255                 1260             


Tyr Thr  His Ser Leu Asp Gly  Ala Gly Leu Phe Leu  Phe Asp His 
    1265                 1270                 1275             


Ala Ala  Glu Glu Tyr Glu His  Ala Lys Lys Leu Ile  Ile Phe Leu 
    1280                 1285                 1290             


Asn Glu  Asn Asn Val Pro Val  Gln Leu Thr Ser Ile  Ser Ala Pro 
    1295                 1300                 1305             


Glu His  Lys Phe Glu Gly Leu  Thr Gln Ile Phe Gln  Lys Ala Tyr 
    1310                 1315                 1320             


Glu His  Glu Gln His Ile Ser  Glu Ser Ile Asn Asn  Ile Val Asp 
    1325                 1330                 1335             


His Ala  Ile Lys Ser Lys Asp  His Ala Thr Phe Asn  Phe Leu Gln 
    1340                 1345                 1350             


Trp Tyr  Val Ala Glu Gln His  Glu Glu Glu Val Leu  Phe Lys Asp 
    1355                 1360                 1365             


Ile Leu  Asp Lys Ile Glu Leu  Ile Gly Asn Glu Asn  His Gly Leu 
    1370                 1375                 1380             


Tyr Leu  Ala Asp Gln Tyr Val  Lys Gly Ile Ala Lys  Ser Arg Lys 
    1385                 1390                 1395             


Ser Gly  Ser 
    1400     


<210> 261
<211> 1401
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 261
Ala Val Ile Gly Asp Leu Lys Cys Thr Ser Asp Asn Ile Asn Asp Lys 
1               5                   10                  15      


Asp Thr Gly Pro Pro Pro Ile Ser Thr Asp Thr Val Asp Val Thr Asn 
            20                  25                  30          


Gly Leu Gly Thr Tyr Tyr Val Leu Asp Arg Val Tyr Leu Asn Thr Thr 
        35                  40                  45              


Leu Phe Leu Asn Gly Tyr Tyr Pro Thr Ser Gly Ser Thr Tyr Arg Asn 
    50                  55                  60                  


Met Ala Leu Lys Gly Ser Val Leu Leu Ser Arg Leu Trp Phe Lys Pro 
65                  70                  75                  80  


Pro Phe Leu Ser Asp Phe Ile Asn Gly Ile Phe Ala Lys Val Lys Asn 
                85                  90                  95      


Thr Lys Val Ile Lys Asp Arg Val Met Tyr Ser Glu Phe Pro Ala Ile 
            100                 105                 110         


Thr Ile Gly Ser Thr Phe Val Asn Thr Ser Tyr Ser Val Val Val Gln 
        115                 120                 125             


Pro Arg Thr Ile Asn Ser Thr Gln Asp Gly Asp Asn Lys Leu Gln Gly 
    130                 135                 140                 


Leu Leu Glu Val Ser Val Cys Gln Tyr Asn Met Cys Glu Tyr Pro Gln 
145                 150                 155                 160 


Thr Ile Cys His Pro Asn Leu Gly Asn His Arg Lys Glu Leu Trp His 
                165                 170                 175     


Leu Asp Thr Gly Val Val Ser Cys Leu Tyr Lys Arg Asn Phe Thr Tyr 
            180                 185                 190         


Asp Val Asn Ala Asp Tyr Leu Tyr Phe His Phe Tyr Gln Glu Gly Gly 
        195                 200                 205             


Thr Phe Tyr Ala Tyr Phe Thr Asp Thr Gly Val Val Thr Lys Phe Leu 
    210                 215                 220                 


Phe Asn Val Tyr Leu Gly Met Ala Leu Ser His Tyr Tyr Val Met Pro 
225                 230                 235                 240 


Leu Thr Cys Asn Ser Lys Leu Thr Leu Glu Tyr Trp Val Thr Pro Leu 
                245                 250                 255     


Thr Ser Arg Gln Tyr Leu Leu Ala Phe Asn Gln Asp Gly Ile Ile Phe 
            260                 265                 270         


Asn Ala Val Asp Cys Met Ser Asp Phe Met Ser Glu Ile Lys Cys Lys 
        275                 280                 285             


Thr Gln Ser Ile Ala Pro Pro Thr Gly Val Tyr Glu Leu Asn Gly Tyr 
    290                 295                 300                 


Thr Val Gln Pro Ile Ala Asp Val Tyr Arg Arg Lys Pro Asn Leu Pro 
305                 310                 315                 320 


Asn Cys Asn Ile Glu Ala Trp Leu Asn Asp Lys Ser Val Pro Ser Pro 
                325                 330                 335     


Leu Asn Trp Glu Arg Lys Thr Phe Ser Asn Cys Asn Phe Asn Met Ser 
            340                 345                 350         


Ser Leu Met Ser Phe Ile Gln Ala Asp Ser Phe Thr Cys Asn Asn Ile 
        355                 360                 365             


Asp Ala Ala Lys Ile Tyr Gly Met Cys Phe Ser Ser Ile Thr Ile Asp 
    370                 375                 380                 


Lys Phe Ala Ile Pro Asn Gly Arg Lys Val Asp Leu Gln Leu Gly Asn 
385                 390                 395                 400 


Leu Gly Tyr Leu Gln Ser Phe Asn Tyr Arg Ile Asp Thr Thr Ala Thr 
                405                 410                 415     


Ser Cys Gln Leu Tyr Tyr Asn Leu Pro Ala Ala Asn Val Ser Val Ser 
            420                 425                 430         


Arg Phe Asn Pro Ser Thr Trp Asn Lys Arg Phe Gly Phe Ile Glu Asp 
        435                 440                 445             


Ser Val Phe Lys Pro Arg Pro Ala Gly Val Leu Thr Asn His Asp Val 
    450                 455                 460                 


Val Tyr Ala Gln His Cys Phe Lys Ala Pro Lys Asn Phe Cys Pro Cys 
465                 470                 475                 480 


Lys Leu Asn Gly Ser Cys Val Gly Ser Gly Pro Gly Lys Asn Asn Gly 
                485                 490                 495     


Ile Gly Thr Cys Pro Ala Gly Thr Asn Tyr Leu Thr Cys Asp Asn Leu 
            500                 505                 510         


Cys Thr Pro Asp Pro Ile Thr Phe Thr Gly Thr Tyr Lys Cys Pro Gln 
        515                 520                 525             


Thr Lys Ser Leu Val Gly Ile Gly Glu His Cys Ser Gly Leu Ala Val 
    530                 535                 540                 


Lys Ser Asp Tyr Cys Gly Gly Asn Ser Cys Thr Cys Arg Pro Gln Ala 
545                 550                 555                 560 


Phe Leu Gly Trp Ser Ala Asp Ser Cys Leu Gln Gly Asp Lys Cys Asn 
                565                 570                 575     


Ile Phe Ala Asn Phe Ile Leu His Asp Val Asn Ser Gly Leu Thr Cys 
            580                 585                 590         


Ser Thr Asp Leu Gln Lys Ala Asn Thr Asp Ile Ile Leu Gly Val Cys 
        595                 600                 605             


Val Asn Tyr Asp Leu Tyr Gly Ile Leu Gly Gln Gly Ile Phe Val Glu 
    610                 615                 620                 


Val Asn Ala Thr Tyr Tyr Asn Ser Trp Gln Asn Leu Leu Tyr Asp Ser 
625                 630                 635                 640 


Asn Gly Asn Leu Tyr Gly Phe Arg Asp Tyr Ile Thr Asn Arg Thr Phe 
                645                 650                 655     


Met Ile Arg Ser Cys Tyr Ser Gly Arg Val Ser Ala Ala Phe His Ala 
            660                 665                 670         


Asn Ser Ser Glu Pro Ala Leu Leu Phe Arg Asn Ile Lys Cys Asn Tyr 
        675                 680                 685             


Val Phe Asn Asn Ser Leu Thr Arg Gln Leu Gln Pro Ile Asn Tyr Phe 
    690                 695                 700                 


Asp Ser Tyr Leu Gly Cys Val Val Asn Ala Tyr Asn Ser Thr Ala Ile 
705                 710                 715                 720 


Ser Val Gln Thr Cys Asp Leu Thr Val Gly Ser Gly Tyr Cys Val Asp 
                725                 730                 735     


Tyr Ser Lys Asn Gly Gly Ser Gly Gly Ala Ile Thr Thr Gly Tyr Arg 
            740                 745                 750         


Phe Thr Asn Phe Glu Pro Phe Thr Val Asn Ser Val Asn Asp Ser Leu 
        755                 760                 765             


Glu Pro Val Gly Gly Leu Tyr Glu Ile Gln Ile Pro Ser Glu Phe Thr 
    770                 775                 780                 


Ile Gly Asn Met Val Glu Phe Ile Gln Thr Ser Ser Pro Lys Val Thr 
785                 790                 795                 800 


Ile Asp Cys Ala Ala Phe Val Cys Gly Asp Tyr Ala Ala Cys Lys Ser 
                805                 810                 815     


Gln Leu Val Glu Tyr Gly Ser Phe Cys Asp Asn Ile Asn Ala Ile Leu 
            820                 825                 830         


Thr Glu Val Asn Glu Leu Leu Asp Thr Thr Gln Leu Gln Val Ala Asn 
        835                 840                 845             


Ser Leu Met Asn Gly Val Thr Leu Ser Thr Lys Leu Lys Asp Gly Val 
    850                 855                 860                 


Asn Phe Asn Val Asp Asp Ile Asn Phe Ser Pro Val Leu Gly Cys Leu 
865                 870                 875                 880 


Gly Ser Glu Cys Ser Lys Ala Ser Ser Arg Ser Ala Ile Glu Asp Leu 
                885                 890                 895     


Leu Phe Asp Lys Val Lys Leu Ser Asp Val Gly Phe Val Glu Ala Tyr 
            900                 905                 910         


Asn Asn Cys Thr Gly Gly Ala Glu Ile Arg Asp Leu Ile Cys Val Gln 
        915                 920                 925             


Ser Tyr Lys Gly Ile Lys Val Leu Pro Pro Leu Leu Ser Glu Asn Gln 
    930                 935                 940                 


Phe Ser Gly Tyr Thr Leu Ala Ala Thr Ser Ala Ser Leu Phe Pro Pro 
945                 950                 955                 960 


Trp Thr Ala Ala Ala Gly Val Pro Phe Tyr Leu Asn Val Gln Tyr Arg 
                965                 970                 975     


Ile Asn Gly Leu Gly Val Thr Met Asp Val Leu Ser Gln Asn Gln Lys 
            980                 985                 990         


Leu Ile Ala Asn Ala Phe Asn Asn  Ala Leu Tyr Ala Ile  Gln Glu Gly 
        995                 1000                 1005             


Phe Asp  Ala Thr Asn Ser Ala  Leu Val Lys Ile Gln  Ala Val Val 
    1010                 1015                 1020             


Asn Ala  Asn Ala Glu Ala Leu  Asn Asn Leu Leu Gln  Gln Leu Ser 
    1025                 1030                 1035             


Asn Arg  Phe Gly Ala Ile Ser  Ala Ser Leu Gln Glu  Ile Leu Ser 
    1040                 1045                 1050             


Arg Leu  Asp Pro Pro Glu Ala  Glu Ala Gln Ile Asp  Arg Leu Ile 
    1055                 1060                 1065             


Asn Gly  Arg Leu Thr Ala Leu  Asn Ala Tyr Val Ser  Gln Gln Leu 
    1070                 1075                 1080             


Ser Asp  Ser Thr Leu Val Lys  Phe Ser Ala Ala Gln  Ala Met Glu 
    1085                 1090                 1095             


Lys Val  Asn Glu Cys Val Lys  Ser Gln Ser Ser Arg  Ile Asn Phe 
    1100                 1105                 1110             


Cys Gly  Asn Gly Asn His Ile  Ile Ser Leu Val Gln  Asn Ala Pro 
    1115                 1120                 1125             


Tyr Gly  Leu Tyr Phe Ile His  Phe Ser Tyr Val Pro  Thr Lys Tyr 
    1130                 1135                 1140             


Val Thr  Ala Arg Val Ser Pro  Gly Leu Cys Ile Ala  Gly Asp Arg 
    1145                 1150                 1155             


Gly Ile  Ala Pro Lys Ser Gly  Tyr Phe Val Asn Val  Asn Asn Thr 
    1160                 1165                 1170             


Trp Met  Tyr Thr Gly Ser Gly  Tyr Tyr Tyr Pro Glu  Pro Ile Thr 
    1175                 1180                 1185             


Glu Asn  Asn Val Val Val Met  Ser Thr Cys Ala Val  Asn Tyr Thr 
    1190                 1195                 1200             


Lys Ala  Pro Tyr Val Met Leu  Asn Thr Leu Gln Ser  Asn Leu Gln 
    1205                 1210                 1215             


Asp Leu  Lys Glu Glu Leu Asp  Gln Leu His Lys Gln  Gly Ser Gly 
    1220                 1225                 1230             


Gly Ser  Gly Asp Ile Ile Lys  Leu Leu Asn Glu Gln  Val Asn Lys 
    1235                 1240                 1245             


Glu Met  Gln Ser Ser Asn Leu  Tyr Met Ser Met Ser  Ser Trp Cys 
    1250                 1255                 1260             


Tyr Thr  His Ser Leu Asp Gly  Ala Gly Leu Phe Leu  Phe Asp His 
    1265                 1270                 1275             


Ala Ala  Glu Glu Tyr Glu His  Ala Lys Lys Leu Ile  Ile Phe Leu 
    1280                 1285                 1290             


Asn Glu  Asn Asn Val Pro Val  Gln Leu Thr Ser Ile  Ser Ala Pro 
    1295                 1300                 1305             


Glu His  Lys Phe Glu Gly Leu  Thr Gln Ile Phe Gln  Lys Ala Tyr 
    1310                 1315                 1320             


Glu His  Glu Gln His Ile Ser  Glu Ser Ile Asn Asn  Ile Val Asp 
    1325                 1330                 1335             


His Ala  Ile Lys Ser Lys Asp  His Ala Thr Phe Asn  Phe Leu Gln 
    1340                 1345                 1350             


Trp Tyr  Val Ala Glu Gln His  Glu Glu Glu Val Leu  Phe Lys Asp 
    1355                 1360                 1365             


Ile Leu  Asp Lys Ile Glu Leu  Ile Gly Asn Glu Asn  His Gly Leu 
    1370                 1375                 1380             


Tyr Leu  Ala Asp Gln Tyr Val  Lys Gly Ile Ala Lys  Ser Arg Lys 
    1385                 1390                 1395             


Ser Gly  Ser 
    1400     


<210> 262
<211> 1401
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 262
Ala Val Ile Gly Asp Leu Lys Cys Thr Ser Asp Asn Ile Asn Asp Lys 
1               5                   10                  15      


Asp Thr Gly Pro Pro Pro Ile Ser Thr Asp Thr Val Asp Val Thr Asn 
            20                  25                  30          


Gly Leu Gly Thr Tyr Tyr Val Leu Asp Arg Val Tyr Leu Asn Thr Thr 
        35                  40                  45              


Leu Phe Leu Asn Gly Tyr Tyr Pro Thr Ser Gly Ser Thr Tyr Arg Asn 
    50                  55                  60                  


Met Ala Leu Lys Gly Ser Val Leu Leu Ser Arg Leu Trp Phe Lys Pro 
65                  70                  75                  80  


Pro Phe Leu Ser Asp Phe Ile Asn Gly Ile Phe Ala Lys Val Lys Asn 
                85                  90                  95      


Thr Lys Val Ile Lys Asp Arg Val Met Tyr Ser Glu Phe Pro Ala Ile 
            100                 105                 110         


Thr Ile Gly Ser Thr Phe Val Asn Thr Ser Tyr Ser Val Val Val Gln 
        115                 120                 125             


Pro Arg Thr Ile Asn Ser Thr Gln Asp Gly Asp Asn Lys Leu Gln Gly 
    130                 135                 140                 


Leu Leu Glu Val Ser Val Cys Gln Tyr Asn Met Cys Glu Tyr Pro Gln 
145                 150                 155                 160 


Thr Ile Cys His Pro Asn Leu Gly Asn His Arg Lys Glu Leu Trp His 
                165                 170                 175     


Leu Asp Thr Gly Val Val Ser Cys Leu Tyr Lys Arg Asn Phe Thr Tyr 
            180                 185                 190         


Asp Val Asn Ala Asp Tyr Leu Tyr Phe His Phe Tyr Gln Glu Gly Gly 
        195                 200                 205             


Thr Phe Tyr Ala Tyr Phe Thr Asp Thr Gly Val Val Thr Lys Phe Leu 
    210                 215                 220                 


Phe Asn Val Tyr Leu Gly Met Ala Leu Ser His Tyr Tyr Val Met Pro 
225                 230                 235                 240 


Leu Thr Cys Asn Ser Lys Leu Thr Leu Glu Tyr Trp Val Thr Pro Leu 
                245                 250                 255     


Thr Ser Arg Gln Tyr Leu Leu Ala Phe Asn Gln Asp Gly Ile Ile Phe 
            260                 265                 270         


Asn Ala Val Asp Cys Met Ser Asp Phe Met Ser Glu Ile Lys Cys Lys 
        275                 280                 285             


Thr Gln Ser Ile Ala Pro Pro Thr Gly Val Tyr Glu Leu Asn Gly Tyr 
    290                 295                 300                 


Thr Val Gln Pro Ile Ala Asp Val Tyr Arg Arg Lys Pro Asn Leu Pro 
305                 310                 315                 320 


Asn Cys Asn Ile Glu Ala Trp Leu Asn Asp Lys Ser Val Pro Ser Pro 
                325                 330                 335     


Leu Asn Trp Glu Arg Lys Thr Phe Ser Asn Cys Asn Phe Asn Met Ser 
            340                 345                 350         


Ser Leu Met Ser Phe Ile Gln Ala Asp Ser Phe Thr Cys Asn Asn Ile 
        355                 360                 365             


Asp Ala Ala Lys Ile Tyr Gly Met Cys Phe Ser Ser Ile Thr Ile Asp 
    370                 375                 380                 


Lys Phe Ala Ile Pro Asn Gly Arg Lys Val Asp Leu Gln Leu Gly Asn 
385                 390                 395                 400 


Leu Gly Tyr Leu Gln Ser Phe Asn Tyr Arg Ile Asp Thr Thr Ala Thr 
                405                 410                 415     


Ser Cys Gln Leu Tyr Tyr Asn Leu Pro Ala Ala Asn Val Ser Val Ser 
            420                 425                 430         


Arg Phe Asn Pro Ser Thr Trp Asn Lys Arg Phe Gly Phe Ile Glu Asp 
        435                 440                 445             


Ser Val Phe Lys Pro Arg Pro Ala Gly Val Leu Thr Asn His Asp Val 
    450                 455                 460                 


Val Tyr Ala Gln His Cys Phe Lys Ala Pro Lys Asn Phe Cys Pro Cys 
465                 470                 475                 480 


Lys Leu Asn Gly Ser Cys Val Gly Ser Gly Pro Gly Lys Asn Asn Gly 
                485                 490                 495     


Ile Gly Thr Cys Pro Ala Gly Thr Asn Tyr Leu Thr Cys Asp Asn Leu 
            500                 505                 510         


Cys Thr Pro Asp Pro Ile Thr Phe Thr Gly Thr Tyr Lys Cys Pro Gln 
        515                 520                 525             


Thr Lys Ser Leu Val Gly Ile Gly Glu His Cys Ser Gly Leu Ala Val 
    530                 535                 540                 


Lys Ser Asp Tyr Cys Gly Gly Asn Ser Cys Thr Cys Arg Pro Gln Ala 
545                 550                 555                 560 


Phe Leu Gly Trp Ser Ala Asp Ser Cys Leu Gln Gly Asp Lys Cys Asn 
                565                 570                 575     


Ile Phe Ala Asn Phe Ile Leu His Asp Val Asn Ser Gly Leu Thr Cys 
            580                 585                 590         


Ser Thr Asp Leu Gln Lys Ala Asn Thr Asp Ile Ile Leu Gly Val Cys 
        595                 600                 605             


Val Asn Tyr Asp Leu Tyr Gly Ile Leu Gly Gln Gly Ile Phe Val Glu 
    610                 615                 620                 


Val Asn Ala Thr Tyr Tyr Asn Ser Trp Gln Asn Leu Leu Tyr Asp Ser 
625                 630                 635                 640 


Asn Gly Asn Leu Tyr Gly Phe Arg Asp Tyr Ile Thr Asn Arg Thr Phe 
                645                 650                 655     


Met Ile Arg Ser Cys Tyr Ser Gly Arg Val Ser Ala Ala Phe His Ala 
            660                 665                 670         


Asn Ser Ser Glu Pro Ala Leu Leu Phe Arg Asn Ile Lys Cys Asn Tyr 
        675                 680                 685             


Val Phe Asn Asn Ser Leu Thr Arg Gln Leu Gln Pro Ile Asn Tyr Phe 
    690                 695                 700                 


Asp Ser Tyr Leu Gly Cys Val Val Asn Ala Tyr Asn Ser Thr Ala Ile 
705                 710                 715                 720 


Ser Val Gln Thr Cys Asp Leu Thr Val Gly Ser Gly Tyr Cys Val Asp 
                725                 730                 735     


Tyr Ser Lys Asn Gly Gly Ser Gly Gly Ala Ile Thr Thr Gly Tyr Arg 
            740                 745                 750         


Phe Thr Asn Phe Glu Pro Phe Thr Val Asn Ser Val Asn Asp Ser Leu 
        755                 760                 765             


Glu Pro Val Gly Gly Leu Tyr Glu Ile Gln Ile Pro Ser Glu Phe Thr 
    770                 775                 780                 


Ile Gly Asn Met Val Glu Phe Ile Gln Thr Ser Ser Pro Lys Val Thr 
785                 790                 795                 800 


Ile Asp Cys Ala Ala Phe Val Cys Gly Asp Tyr Ala Ala Cys Lys Ser 
                805                 810                 815     


Gln Leu Val Glu Tyr Gly Ser Phe Cys Asp Asn Ile Asn Ala Ile Leu 
            820                 825                 830         


Thr Glu Val Asn Glu Leu Leu Asp Thr Thr Gln Leu Gln Val Ala Asn 
        835                 840                 845             


Ser Leu Met Asn Gly Val Thr Leu Ser Thr Lys Leu Lys Asp Gly Val 
    850                 855                 860                 


Asn Phe Asn Val Asp Asp Ile Asn Phe Ser Pro Val Leu Gly Cys Leu 
865                 870                 875                 880 


Gly Ser Glu Cys Ser Lys Ala Ser Ser Arg Ser Ala Ile Glu Asp Leu 
                885                 890                 895     


Leu Phe Asp Lys Val Lys Leu Ser Asp Val Gly Phe Val Glu Ala Tyr 
            900                 905                 910         


Asn Asn Cys Thr Gly Gly Ala Glu Ile Arg Asp Leu Ile Cys Val Gln 
        915                 920                 925             


Ser Tyr Lys Gly Ile Lys Val Leu Pro Pro Leu Leu Ser Glu Asn Gln 
    930                 935                 940                 


Phe Ser Gly Tyr Thr Leu Ala Ala Thr Ser Ala Ser Leu Phe Pro Pro 
945                 950                 955                 960 


Trp Thr Ala Ala Ala Gly Val Pro Phe Tyr Leu Asn Val Gln Tyr Arg 
                965                 970                 975     


Ile Asn Gly Leu Gly Val Thr Met Asp Val Leu Ser Gln Asn Gln Lys 
            980                 985                 990         


Leu Ile Ala Asn Ala Phe Asn Asn  Ala Leu Tyr Ala Ile  Gln Glu Gly 
        995                 1000                 1005             


Phe Asp  Ala Thr Asn Ser Ala  Leu Val Lys Ile Gln  Ala Val Val 
    1010                 1015                 1020             


Asn Ala  Asn Ala Glu Ala Leu  Asn Asn Leu Leu Gln  Gln Leu Ser 
    1025                 1030                 1035             


Asn Arg  Phe Gly Ala Ile Ser  Ala Ser Leu Gln Glu  Ile Leu Ser 
    1040                 1045                 1050             


Arg Leu  Asp Pro Pro Glu Ala  Glu Ala Gln Ile Asp  Arg Leu Ile 
    1055                 1060                 1065             


Asn Gly  Arg Leu Thr Ala Leu  Asn Ala Tyr Val Ser  Gln Gln Leu 
    1070                 1075                 1080             


Ser Asp  Ser Thr Leu Val Lys  Phe Ser Ala Ala Gln  Ala Met Glu 
    1085                 1090                 1095             


Lys Val  Asn Glu Cys Val Lys  Ser Gln Ser Ser Arg  Ile Asn Phe 
    1100                 1105                 1110             


Cys Gly  Asn Gly Asn His Ile  Ile Ser Leu Val Gln  Asn Ala Pro 
    1115                 1120                 1125             


Tyr Gly  Leu Tyr Phe Ile His  Phe Ser Tyr Val Pro  Thr Lys Tyr 
    1130                 1135                 1140             


Val Thr  Ala Arg Val Ser Pro  Gly Leu Cys Ile Ala  Gly Asp Arg 
    1145                 1150                 1155             


Gly Ile  Ala Pro Lys Ser Gly  Tyr Phe Val Asn Val  Asn Asn Thr 
    1160                 1165                 1170             


Trp Met  Tyr Thr Gly Ser Gly  Tyr Tyr Tyr Pro Glu  Pro Ile Thr 
    1175                 1180                 1185             


Glu Asn  Asn Val Val Val Met  Ser Thr Cys Ala Val  Asn Tyr Thr 
    1190                 1195                 1200             


Lys Ala  Pro Tyr Val Met Leu  Asn Thr Ser Ile Ser  Glu Leu Gln 
    1205                 1210                 1215             


Asp Ile  Lys Glu Glu Leu Asp  Gln Ile His Lys Gln  Gly Ser Gly 
    1220                 1225                 1230             


Gly Ser  Gly Asp Ile Ile Lys  Leu Leu Asn Glu Gln  Val Asn Lys 
    1235                 1240                 1245             


Glu Met  Gln Ser Ser Asn Leu  Tyr Met Ser Met Ser  Ser Trp Cys 
    1250                 1255                 1260             


Tyr Thr  His Ser Leu Asp Gly  Ala Gly Leu Phe Leu  Phe Asp His 
    1265                 1270                 1275             


Ala Ala  Glu Glu Tyr Glu His  Ala Lys Lys Leu Ile  Ile Phe Leu 
    1280                 1285                 1290             


Asn Glu  Asn Asn Val Pro Val  Gln Leu Thr Ser Ile  Ser Ala Pro 
    1295                 1300                 1305             


Glu His  Lys Phe Glu Gly Leu  Thr Gln Ile Phe Gln  Lys Ala Tyr 
    1310                 1315                 1320             


Glu His  Glu Gln His Ile Ser  Glu Ser Ile Asn Asn  Ile Val Asp 
    1325                 1330                 1335             


His Ala  Ile Lys Ser Lys Asp  His Ala Thr Phe Asn  Phe Leu Gln 
    1340                 1345                 1350             


Trp Tyr  Val Ala Glu Gln His  Glu Glu Glu Val Leu  Phe Lys Asp 
    1355                 1360                 1365             


Ile Leu  Asp Lys Ile Glu Leu  Ile Gly Asn Glu Asn  His Gly Leu 
    1370                 1375                 1380             


Tyr Leu  Ala Asp Gln Tyr Val  Lys Gly Ile Ala Lys  Ser Arg Lys 
    1385                 1390                 1395             


Ser Gly  Ser 
    1400     


<210> 263
<211> 1401
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 263
Ala Val Ile Gly Asp Leu Lys Cys Thr Ser Asp Asn Ile Asn Asp Lys 
1               5                   10                  15      


Asp Thr Gly Pro Pro Pro Ile Ser Thr Asp Thr Val Asp Val Thr Asn 
            20                  25                  30          


Gly Leu Gly Thr Tyr Tyr Val Leu Asp Arg Val Tyr Leu Asn Thr Thr 
        35                  40                  45              


Leu Phe Leu Asn Gly Tyr Tyr Pro Thr Ser Gly Ser Thr Tyr Arg Asn 
    50                  55                  60                  


Met Ala Leu Lys Gly Ser Val Leu Leu Ser Arg Leu Trp Phe Lys Pro 
65                  70                  75                  80  


Pro Phe Leu Ser Asp Phe Ile Asn Gly Ile Phe Ala Lys Val Lys Asn 
                85                  90                  95      


Thr Lys Val Ile Lys Asp Arg Val Met Tyr Ser Glu Phe Pro Ala Ile 
            100                 105                 110         


Thr Ile Gly Ser Thr Phe Val Asn Thr Ser Tyr Ser Val Val Val Gln 
        115                 120                 125             


Pro Arg Thr Ile Asn Ser Thr Gln Asp Gly Asp Asn Lys Leu Gln Gly 
    130                 135                 140                 


Leu Leu Glu Val Ser Val Cys Gln Tyr Asn Met Cys Glu Tyr Pro Gln 
145                 150                 155                 160 


Thr Ile Cys His Pro Asn Leu Gly Asn His Arg Lys Glu Leu Trp His 
                165                 170                 175     


Leu Asp Thr Gly Val Val Ser Cys Leu Tyr Lys Arg Asn Phe Thr Tyr 
            180                 185                 190         


Asp Val Asn Ala Asp Tyr Leu Tyr Phe His Phe Tyr Gln Glu Gly Gly 
        195                 200                 205             


Thr Phe Tyr Ala Tyr Phe Thr Asp Thr Gly Val Val Thr Lys Phe Leu 
    210                 215                 220                 


Phe Asn Val Tyr Leu Gly Met Ala Leu Ser His Tyr Tyr Val Met Pro 
225                 230                 235                 240 


Leu Thr Cys Asn Ser Lys Leu Thr Leu Glu Tyr Trp Val Thr Pro Leu 
                245                 250                 255     


Thr Ser Arg Gln Tyr Leu Leu Ala Phe Asn Gln Asp Gly Ile Ile Phe 
            260                 265                 270         


Asn Ala Val Asp Cys Met Ser Asp Phe Met Ser Glu Ile Lys Cys Lys 
        275                 280                 285             


Thr Gln Ser Ile Ala Pro Pro Thr Gly Val Tyr Glu Leu Asn Gly Tyr 
    290                 295                 300                 


Thr Val Gln Pro Ile Ala Asp Val Tyr Arg Arg Lys Pro Asn Leu Pro 
305                 310                 315                 320 


Asn Cys Asn Ile Glu Ala Trp Leu Asn Asp Lys Ser Val Pro Ser Pro 
                325                 330                 335     


Leu Asn Trp Glu Arg Lys Thr Phe Ser Asn Cys Asn Phe Asn Met Ser 
            340                 345                 350         


Ser Leu Met Ser Phe Ile Gln Ala Asp Ser Phe Thr Cys Asn Asn Ile 
        355                 360                 365             


Asp Ala Ala Lys Ile Tyr Gly Met Cys Phe Ser Ser Ile Thr Ile Asp 
    370                 375                 380                 


Lys Phe Ala Ile Pro Asn Gly Arg Lys Val Asp Leu Gln Leu Gly Asn 
385                 390                 395                 400 


Leu Gly Tyr Leu Gln Ser Phe Asn Tyr Arg Ile Asp Thr Thr Ala Thr 
                405                 410                 415     


Ser Cys Gln Leu Tyr Tyr Asn Leu Pro Ala Ala Asn Val Ser Val Ser 
            420                 425                 430         


Arg Phe Asn Pro Ser Thr Trp Asn Lys Arg Phe Gly Phe Ile Glu Asp 
        435                 440                 445             


Ser Val Phe Lys Pro Arg Pro Ala Gly Val Leu Thr Asn His Asp Val 
    450                 455                 460                 


Val Tyr Ala Gln His Cys Phe Lys Ala Pro Lys Asn Phe Cys Pro Cys 
465                 470                 475                 480 


Lys Leu Asn Gly Ser Cys Val Gly Ser Gly Pro Gly Lys Asn Asn Gly 
                485                 490                 495     


Ile Gly Thr Cys Pro Ala Gly Thr Asn Tyr Leu Thr Cys Asp Asn Leu 
            500                 505                 510         


Cys Thr Pro Asp Pro Ile Thr Phe Thr Gly Thr Tyr Lys Cys Pro Gln 
        515                 520                 525             


Thr Lys Ser Leu Val Gly Ile Gly Glu His Cys Ser Gly Leu Ala Val 
    530                 535                 540                 


Lys Ser Asp Tyr Cys Gly Gly Asn Ser Cys Thr Cys Arg Pro Gln Ala 
545                 550                 555                 560 


Phe Leu Gly Trp Ser Ala Asp Ser Cys Leu Gln Gly Asp Lys Cys Asn 
                565                 570                 575     


Ile Phe Ala Asn Phe Ile Leu His Asp Val Asn Ser Gly Leu Thr Cys 
            580                 585                 590         


Ser Thr Asp Leu Gln Lys Ala Asn Thr Asp Ile Ile Leu Gly Val Cys 
        595                 600                 605             


Val Asn Tyr Asp Leu Tyr Gly Ile Leu Gly Gln Gly Ile Phe Val Glu 
    610                 615                 620                 


Val Asn Ala Thr Tyr Tyr Asn Ser Trp Gln Asn Leu Leu Tyr Asp Ser 
625                 630                 635                 640 


Asn Gly Asn Leu Tyr Gly Phe Arg Asp Tyr Ile Thr Asn Arg Thr Phe 
                645                 650                 655     


Met Ile Arg Ser Cys Tyr Ser Gly Arg Val Ser Ala Ala Phe His Ala 
            660                 665                 670         


Asn Ser Ser Glu Pro Ala Leu Leu Phe Arg Asn Ile Lys Cys Asn Tyr 
        675                 680                 685             


Val Phe Asn Asn Ser Leu Thr Arg Gln Leu Gln Pro Ile Asn Tyr Phe 
    690                 695                 700                 


Asp Ser Tyr Leu Gly Cys Val Val Asn Ala Tyr Asn Ser Thr Ala Ile 
705                 710                 715                 720 


Ser Val Gln Thr Cys Asp Leu Thr Val Gly Ser Gly Tyr Cys Val Asp 
                725                 730                 735     


Tyr Ser Lys Asn Gly Gly Ser Gly Gly Ala Ile Thr Thr Gly Tyr Arg 
            740                 745                 750         


Phe Thr Asn Phe Glu Pro Phe Thr Val Asn Ser Val Asn Asp Ser Leu 
        755                 760                 765             


Glu Pro Val Gly Gly Leu Tyr Glu Ile Gln Ile Pro Ser Glu Phe Thr 
    770                 775                 780                 


Ile Gly Asn Met Val Glu Phe Ile Gln Thr Ser Ser Pro Lys Val Thr 
785                 790                 795                 800 


Ile Asp Cys Ala Ala Phe Val Cys Gly Asp Tyr Ala Ala Cys Lys Ser 
                805                 810                 815     


Gln Leu Val Glu Tyr Gly Ser Phe Cys Asp Asn Ile Asn Ala Ile Leu 
            820                 825                 830         


Thr Glu Val Asn Glu Leu Leu Asp Thr Thr Gln Leu Gln Val Ala Asn 
        835                 840                 845             


Ser Leu Met Asn Gly Val Thr Leu Ser Thr Lys Leu Lys Asp Gly Val 
    850                 855                 860                 


Asn Phe Asn Val Asp Asp Ile Asn Phe Ser Pro Val Leu Gly Cys Leu 
865                 870                 875                 880 


Gly Ser Glu Cys Ser Lys Ala Ser Ser Arg Ser Ala Ile Glu Asp Leu 
                885                 890                 895     


Leu Phe Asp Lys Val Lys Leu Ser Asp Val Gly Phe Val Glu Ala Tyr 
            900                 905                 910         


Asn Asn Cys Thr Gly Gly Ala Glu Ile Arg Asp Leu Ile Cys Val Gln 
        915                 920                 925             


Ser Tyr Lys Gly Ile Lys Val Leu Pro Pro Leu Leu Ser Glu Asn Gln 
    930                 935                 940                 


Phe Ser Gly Tyr Thr Leu Ala Ala Thr Ser Ala Ser Leu Phe Pro Pro 
945                 950                 955                 960 


Trp Thr Ala Ala Ala Gly Val Pro Phe Tyr Leu Asn Val Gln Tyr Arg 
                965                 970                 975     


Ile Asn Gly Leu Gly Val Thr Met Asp Val Leu Ser Gln Asn Gln Lys 
            980                 985                 990         


Leu Ile Ala Asn Ala Phe Asn Asn  Ala Leu Tyr Ala Ile  Gln Glu Gly 
        995                 1000                 1005             


Phe Asp  Ala Thr Asn Ser Ala  Leu Val Lys Ile Gln  Ala Val Val 
    1010                 1015                 1020             


Asn Ala  Asn Ala Glu Ala Leu  Asn Asn Leu Leu Gln  Gln Leu Ser 
    1025                 1030                 1035             


Asn Arg  Phe Gly Ala Ile Ser  Ala Ser Leu Gln Glu  Ile Leu Ser 
    1040                 1045                 1050             


Arg Leu  Asp Pro Pro Glu Ala  Glu Ala Gln Ile Asp  Arg Leu Ile 
    1055                 1060                 1065             


Asn Gly  Arg Leu Thr Ala Leu  Asn Ala Tyr Val Ser  Gln Gln Leu 
    1070                 1075                 1080             


Ser Asp  Ser Thr Leu Val Lys  Phe Ser Ala Ala Gln  Ala Met Glu 
    1085                 1090                 1095             


Lys Val  Asn Glu Cys Val Lys  Ser Gln Ser Ser Arg  Ile Asn Phe 
    1100                 1105                 1110             


Cys Gly  Asn Gly Asn His Ile  Ile Ser Leu Val Gln  Asn Ala Pro 
    1115                 1120                 1125             


Tyr Gly  Leu Tyr Phe Ile His  Phe Ser Tyr Val Pro  Thr Lys Tyr 
    1130                 1135                 1140             


Val Thr  Ala Arg Val Ser Pro  Gly Leu Cys Ile Ala  Gly Asp Arg 
    1145                 1150                 1155             


Gly Ile  Ala Pro Lys Ser Gly  Tyr Phe Val Asn Val  Asn Asn Thr 
    1160                 1165                 1170             


Trp Met  Tyr Thr Gly Ser Gly  Tyr Tyr Tyr Pro Glu  Pro Ile Thr 
    1175                 1180                 1185             


Glu Asn  Asn Val Val Val Met  Ser Thr Cys Ala Val  Asn Tyr Thr 
    1190                 1195                 1200             


Lys Ala  Pro Tyr Val Met Leu  Asn Thr Ser Ile Ser  Glu Leu Gln 
    1205                 1210                 1215             


Asp Leu  Lys Glu Glu Leu Asp  Gln Leu His Lys Gln  Gly Ser Gly 
    1220                 1225                 1230             


Gly Ser  Gly Asp Ile Ile Lys  Leu Leu Asn Glu Gln  Val Asn Lys 
    1235                 1240                 1245             


Glu Met  Gln Ser Ser Asn Leu  Tyr Met Ser Met Ser  Ser Trp Cys 
    1250                 1255                 1260             


Tyr Thr  His Ser Leu Asp Gly  Ala Gly Leu Phe Leu  Phe Asp His 
    1265                 1270                 1275             


Ala Ala  Glu Glu Tyr Glu His  Ala Lys Lys Leu Ile  Ile Phe Leu 
    1280                 1285                 1290             


Asn Glu  Asn Asn Val Pro Val  Gln Leu Thr Ser Ile  Ser Ala Pro 
    1295                 1300                 1305             


Glu His  Lys Phe Glu Gly Leu  Thr Gln Ile Phe Gln  Lys Ala Tyr 
    1310                 1315                 1320             


Glu His  Glu Gln His Ile Ser  Glu Ser Ile Asn Asn  Ile Val Asp 
    1325                 1330                 1335             


His Ala  Ile Lys Ser Lys Asp  His Ala Thr Phe Asn  Phe Leu Gln 
    1340                 1345                 1350             


Trp Tyr  Val Ala Glu Gln His  Glu Glu Glu Val Leu  Phe Lys Asp 
    1355                 1360                 1365             


Ile Leu  Asp Lys Ile Glu Leu  Ile Gly Asn Glu Asn  His Gly Leu 
    1370                 1375                 1380             


Tyr Leu  Ala Asp Gln Tyr Val  Lys Gly Ile Ala Lys  Ser Arg Lys 
    1385                 1390                 1395             


Ser Gly  Ser 
    1400     


<210> 264
<211> 1209
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 264
Cys Gln Thr Thr Asn Gly Leu Asn Thr Ser Tyr Ser Val Cys Asn Gly 
1               5                   10                  15      


Cys Val Gly Tyr Ser Glu Asn Val Phe Ala Val Glu Ser Gly Gly Tyr 
            20                  25                  30          


Ile Pro Ser Asp Phe Ala Phe Asn Asn Trp Phe Leu Leu Thr Asn Thr 
        35                  40                  45              


Ser Ser Val Val Asp Gly Val Val Arg Ser Phe Gln Pro Leu Leu Leu 
    50                  55                  60                  


Asn Cys Leu Trp Ser Val Ser Gly Leu Arg Phe Thr Thr Gly Phe Val 
65                  70                  75                  80  


Tyr Phe Asn Gly Thr Gly Arg Gly Asp Cys Lys Gly Phe Ser Ser Asp 
                85                  90                  95      


Val Leu Ser Asp Val Ile Arg Tyr Asn Leu Asn Phe Glu Glu Asn Leu 
            100                 105                 110         


Arg Arg Gly Thr Ile Leu Phe Lys Thr Ser Tyr Gly Val Val Val Phe 
        115                 120                 125             


Tyr Cys Thr Asn Asn Thr Leu Val Ser Gly Asp Ala His Ile Pro Phe 
    130                 135                 140                 


Gly Thr Val Leu Gly Asn Phe Tyr Cys Phe Val Asn Thr Thr Ile Gly 
145                 150                 155                 160 


Asn Glu Thr Thr Ser Ala Phe Val Gly Ala Leu Pro Lys Thr Val Arg 
                165                 170                 175     


Glu Phe Val Ile Ser Arg Thr Gly His Phe Tyr Ile Asn Gly Tyr Arg 
            180                 185                 190         


Tyr Phe Thr Leu Gly Asn Val Glu Ala Val Asn Phe Asn Val Thr Thr 
        195                 200                 205             


Ala Glu Thr Thr Asp Phe Cys Thr Val Ala Leu Ala Ser Tyr Ala Asp 
    210                 215                 220                 


Val Leu Val Asn Val Ser Gln Thr Ser Ile Ala Asn Ile Ile Tyr Cys 
225                 230                 235                 240 


Asn Ser Val Ile Asn Arg Leu Arg Cys Asp Gln Leu Ser Phe Asp Val 
                245                 250                 255     


Pro Asp Gly Phe Tyr Ser Thr Ser Pro Ile Gln Ser Val Glu Leu Pro 
            260                 265                 270         


Val Ser Ile Val Ser Leu Pro Val Tyr His Lys His Thr Phe Ile Val 
        275                 280                 285             


Leu Tyr Val Asp Phe Lys Pro Gln Ser Gly Gly Gly Lys Cys Phe Asn 
    290                 295                 300                 


Cys Tyr Pro Ala Gly Val Asn Ile Thr Leu Ala Asn Phe Asn Glu Thr 
305                 310                 315                 320 


Lys Gly Pro Leu Cys Val Asp Thr Ser His Phe Thr Thr Lys Tyr Val 
                325                 330                 335     


Ala Val Tyr Ala Asn Val Gly Arg Trp Ser Ala Ser Ile Asn Thr Gly 
            340                 345                 350         


Asn Cys Pro Phe Ser Phe Gly Lys Val Asn Asn Phe Val Lys Phe Gly 
        355                 360                 365             


Ser Val Cys Phe Ser Leu Lys Asp Ile Pro Gly Gly Cys Ala Met Pro 
    370                 375                 380                 


Ile Val Ala Asn Trp Ala Tyr Ser Lys Tyr Tyr Thr Ile Gly Ser Leu 
385                 390                 395                 400 


Tyr Val Ser Trp Ser Asp Gly Asp Gly Ile Thr Gly Val Pro Gln Pro 
                405                 410                 415     


Val Glu Gly Val Ser Ser Phe Met Asn Val Thr Leu Asp Lys Cys Thr 
            420                 425                 430         


Lys Tyr Asn Ile Tyr Asp Val Ser Gly Val Gly Val Ile Arg Val Ser 
        435                 440                 445             


Asn Asp Thr Phe Leu Asn Gly Ile Thr Tyr Thr Ser Thr Ser Gly Asn 
    450                 455                 460                 


Leu Leu Gly Phe Lys Asp Val Thr Lys Gly Thr Ile Tyr Ser Ile Thr 
465                 470                 475                 480 


Pro Cys Asn Pro Pro Asp Gln Leu Val Val Tyr Gln Gln Ala Val Val 
                485                 490                 495     


Gly Ala Met Leu Ser Glu Asn Phe Thr Ser Tyr Gly Phe Ser Asn Val 
            500                 505                 510         


Val Glu Leu Pro Lys Phe Phe Tyr Ala Ser Asn Gly Thr Tyr Asn Cys 
        515                 520                 525             


Thr Asp Ala Val Leu Thr Tyr Ser Ser Phe Gly Val Cys Ala Asp Gly 
    530                 535                 540                 


Ser Ile Ile Ala Val Gln Pro Arg Asn Val Ser Tyr Asp Ser Val Ser 
545                 550                 555                 560 


Ala Ile Val Thr Ala Asn Leu Ser Ile Pro Ser Asn Trp Thr Thr Ser 
                565                 570                 575     


Val Gln Val Glu Tyr Leu Gln Ile Thr Ser Thr Pro Ile Val Val Asp 
            580                 585                 590         


Cys Ser Thr Tyr Val Cys Asn Gly Asn Val Arg Cys Val Glu Leu Leu 
        595                 600                 605             


Lys Gln Tyr Thr Ser Ala Cys Lys Thr Ile Glu Asp Ala Leu Arg Asn 
    610                 615                 620                 


Ser Ala Met Leu Glu Ser Ala Asp Val Ser Glu Met Leu Thr Phe Asp 
625                 630                 635                 640 


Lys Lys Ala Phe Thr Leu Ala Asn Val Ser Ser Phe Gly Asp Tyr Asn 
                645                 650                 655     


Leu Ser Ser Val Ile Pro Ser Leu Pro Arg Ser Gly Ser Arg Val Ala 
            660                 665                 670         


Gly Arg Ser Ala Ile Glu Asp Ile Leu Phe Ser Lys Leu Val Thr Ser 
        675                 680                 685             


Gly Leu Gly Thr Val Asp Ala Asp Tyr Lys Lys Cys Thr Lys Gly Leu 
    690                 695                 700                 


Ser Ile Ala Asp Leu Ala Cys Ala Gln Tyr Tyr Asn Gly Ile Met Val 
705                 710                 715                 720 


Leu Pro Gly Val Ala Asp Ala Glu Arg Met Ala Met Tyr Thr Gly Ser 
                725                 730                 735     


Leu Ile Gly Gly Ile Ala Leu Gly Gly Leu Thr Ser Ala Ala Ser Ile 
            740                 745                 750         


Pro Phe Ser Leu Ala Ile Gln Ser Arg Leu Asn Tyr Val Ala Leu Gln 
        755                 760                 765             


Thr Asp Val Leu Gln Glu Asn Gln Lys Ile Leu Ala Ala Ser Phe Asn 
    770                 775                 780                 


Lys Ala Met Thr Asn Ile Val Asp Ala Phe Thr Gly Val Asn Asp Ala 
785                 790                 795                 800 


Ile Thr Gln Thr Ser Gln Ala Leu Gln Thr Val Ala Thr Ala Leu Asn 
                805                 810                 815     


Lys Ile Gln Asp Val Val Asn Gln Gln Gly Asn Ser Leu Asn His Leu 
            820                 825                 830         


Thr Ser Gln Leu Arg Gln Asn Phe Gln Ala Ile Ser Ser Ser Ile Gln 
        835                 840                 845             


Ala Ile Tyr Asp Arg Leu Asp Pro Pro Gln Ala Asp Gln Gln Val Asp 
    850                 855                 860                 


Arg Leu Ile Thr Gly Arg Leu Ala Ala Leu Asn Val Phe Val Ser His 
865                 870                 875                 880 


Thr Leu Thr Lys Tyr Thr Glu Val Arg Ala Ser Arg Gln Leu Ala Gln 
                885                 890                 895     


Gln Lys Val Asn Glu Cys Val Lys Ser Gln Ser Lys Arg Tyr Gly Phe 
            900                 905                 910         


Cys Gly Asn Gly Thr His Ile Phe Ser Leu Val Asn Ala Ala Pro Glu 
        915                 920                 925             


Gly Leu Val Phe Leu His Thr Val Leu Leu Pro Thr Gln Tyr Lys Asp 
    930                 935                 940                 


Val Glu Ala Trp Ser Gly Leu Cys Val Asp Gly Arg Asn Gly Tyr Val 
945                 950                 955                 960 


Leu Arg Gln Pro Asn Leu Ala Leu Tyr Lys Glu Gly Asn Tyr Tyr Arg 
                965                 970                 975     


Ile Thr Ser Arg Ile Met Phe Glu Pro Arg Ile Pro Thr Ile Ala Asp 
            980                 985                 990         


Phe Val Gln Ile Glu Asn Cys Asn  Val Thr Phe Val Asn  Ile Ser Arg 
        995                 1000                 1005             


Ser Glu  Leu Gln Thr Ile Val  Pro Glu Tyr Ile Asp  Leu Asn Lys 
    1010                 1015                 1020             


Thr Leu  Gln Glu Leu Ser Tyr  Lys Leu Pro Asn Leu  Thr Val Lys 
    1025                 1030                 1035             


Gly Ser  Gly Gly Ser Gly Asp  Ile Ile Lys Leu Leu  Asn Glu Gln 
    1040                 1045                 1050             


Val Asn  Lys Glu Met Gln Ser  Ser Asn Leu Tyr Met  Ser Met Ser 
    1055                 1060                 1065             


Ser Trp  Cys Tyr Thr His Ser  Leu Asp Gly Ala Gly  Leu Phe Leu 
    1070                 1075                 1080             


Phe Asp  His Ala Ala Glu Glu  Tyr Glu His Ala Lys  Lys Leu Ile 
    1085                 1090                 1095             


Ile Phe  Leu Asn Glu Asn Asn  Val Pro Val Gln Leu  Thr Ser Ile 
    1100                 1105                 1110             


Ser Ala  Pro Glu His Lys Phe  Glu Gly Leu Thr Gln  Ile Phe Gln 
    1115                 1120                 1125             


Lys Ala  Tyr Glu His Glu Gln  His Ile Ser Glu Ser  Ile Asn Asn 
    1130                 1135                 1140             


Ile Val  Asp His Ala Ile Lys  Ser Lys Asp His Ala  Thr Phe Asn 
    1145                 1150                 1155             


Phe Leu  Gln Trp Tyr Val Ala  Glu Gln His Glu Glu  Glu Val Leu 
    1160                 1165                 1170             


Phe Lys  Asp Ile Leu Asp Lys  Ile Glu Leu Ile Gly  Asn Glu Asn 
    1175                 1180                 1185             


His Gly  Leu Tyr Leu Ala Asp  Gln Tyr Val Lys Gly  Ile Ala Lys 
    1190                 1195                 1200             


Ser Arg  Lys Ser Gly Ser 
    1205                 


<210> 265
<211> 1210
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 265
Cys Gln Thr Thr Asn Gly Leu Asn Thr Ser Tyr Ser Val Cys Asn Gly 
1               5                   10                  15      


Cys Val Gly Tyr Ser Glu Asn Val Phe Ala Val Glu Ser Gly Gly Tyr 
            20                  25                  30          


Ile Pro Ser Asp Phe Ala Phe Asn Asn Trp Phe Leu Leu Thr Asn Thr 
        35                  40                  45              


Ser Ser Val Val Asp Gly Val Val Arg Ser Phe Gln Pro Leu Leu Leu 
    50                  55                  60                  


Asn Cys Leu Trp Ser Val Ser Gly Leu Arg Phe Thr Thr Gly Phe Val 
65                  70                  75                  80  


Tyr Phe Asn Gly Thr Gly Arg Gly Asp Cys Lys Gly Phe Ser Ser Asp 
                85                  90                  95      


Val Leu Ser Asp Val Ile Arg Tyr Asn Leu Asn Phe Glu Glu Asn Leu 
            100                 105                 110         


Arg Arg Gly Thr Ile Leu Phe Lys Thr Ser Tyr Gly Val Val Val Phe 
        115                 120                 125             


Tyr Cys Thr Asn Asn Thr Leu Val Ser Gly Asp Ala His Ile Pro Phe 
    130                 135                 140                 


Gly Thr Val Leu Gly Asn Phe Tyr Cys Phe Val Asn Thr Thr Ile Gly 
145                 150                 155                 160 


Asn Glu Thr Thr Ser Ala Phe Val Gly Ala Leu Pro Lys Thr Val Arg 
                165                 170                 175     


Glu Phe Val Ile Ser Arg Thr Gly His Phe Tyr Ile Asn Gly Tyr Arg 
            180                 185                 190         


Tyr Phe Thr Leu Gly Asn Val Glu Ala Val Asn Phe Asn Val Thr Thr 
        195                 200                 205             


Ala Glu Thr Thr Asp Phe Cys Thr Val Ala Leu Ala Ser Tyr Ala Asp 
    210                 215                 220                 


Val Leu Val Asn Val Ser Gln Thr Ser Ile Ala Asn Ile Ile Tyr Cys 
225                 230                 235                 240 


Asn Ser Val Ile Asn Arg Leu Arg Cys Asp Gln Leu Ser Phe Asp Val 
                245                 250                 255     


Pro Asp Gly Phe Tyr Ser Thr Ser Pro Ile Gln Ser Val Glu Leu Pro 
            260                 265                 270         


Val Ser Ile Val Ser Leu Pro Val Tyr His Lys His Thr Phe Ile Val 
        275                 280                 285             


Leu Tyr Val Asp Phe Lys Pro Gln Ser Gly Gly Gly Lys Cys Phe Asn 
    290                 295                 300                 


Cys Tyr Pro Ala Gly Val Asn Ile Thr Leu Ala Asn Phe Asn Glu Thr 
305                 310                 315                 320 


Lys Gly Pro Leu Cys Val Asp Thr Ser His Phe Thr Thr Lys Tyr Val 
                325                 330                 335     


Ala Val Tyr Ala Asn Val Gly Arg Trp Ser Ala Ser Ile Asn Thr Gly 
            340                 345                 350         


Asn Cys Pro Phe Ser Phe Gly Lys Val Asn Asn Phe Val Lys Phe Gly 
        355                 360                 365             


Ser Val Cys Phe Ser Leu Lys Asp Ile Pro Gly Gly Cys Ala Met Pro 
    370                 375                 380                 


Ile Val Ala Asn Trp Ala Tyr Ser Lys Tyr Tyr Thr Ile Gly Ser Leu 
385                 390                 395                 400 


Tyr Val Ser Trp Ser Asp Gly Asp Gly Ile Thr Gly Val Pro Gln Pro 
                405                 410                 415     


Val Glu Gly Val Ser Ser Phe Met Asn Val Thr Leu Asp Lys Cys Thr 
            420                 425                 430         


Lys Tyr Asn Ile Tyr Asp Val Ser Gly Val Gly Val Ile Arg Val Ser 
        435                 440                 445             


Asn Asp Thr Phe Leu Asn Gly Ile Thr Tyr Thr Ser Thr Ser Gly Asn 
    450                 455                 460                 


Leu Leu Gly Phe Lys Asp Val Thr Lys Gly Thr Ile Tyr Ser Ile Thr 
465                 470                 475                 480 


Pro Cys Asn Pro Pro Asp Gln Leu Val Val Tyr Gln Gln Ala Val Val 
                485                 490                 495     


Gly Ala Met Leu Ser Glu Asn Phe Thr Ser Tyr Gly Phe Ser Asn Val 
            500                 505                 510         


Val Glu Leu Pro Lys Phe Phe Tyr Ala Ser Asn Gly Thr Tyr Asn Cys 
        515                 520                 525             


Thr Asp Ala Val Leu Thr Tyr Ser Ser Phe Gly Val Cys Ala Asp Gly 
    530                 535                 540                 


Ser Ile Ile Ala Val Gln Pro Arg Asn Val Ser Tyr Asp Ser Val Ser 
545                 550                 555                 560 


Ala Ile Val Thr Ala Asn Leu Ser Ile Pro Ser Asn Trp Thr Thr Ser 
                565                 570                 575     


Val Gln Val Glu Tyr Leu Gln Ile Thr Ser Thr Pro Ile Val Val Asp 
            580                 585                 590         


Cys Ser Thr Tyr Val Cys Asn Gly Asn Val Arg Cys Val Glu Leu Leu 
        595                 600                 605             


Lys Gln Tyr Thr Ser Ala Cys Lys Thr Ile Glu Asp Ala Leu Arg Asn 
    610                 615                 620                 


Ser Ala Met Leu Glu Ser Ala Asp Val Ser Glu Met Leu Thr Phe Asp 
625                 630                 635                 640 


Lys Lys Ala Phe Thr Leu Ala Asn Val Ser Ser Phe Gly Asp Tyr Asn 
                645                 650                 655     


Leu Ser Ser Val Ile Pro Ser Leu Pro Arg Ser Gly Ser Arg Val Ala 
            660                 665                 670         


Gly Arg Ser Ala Ile Glu Asp Ile Leu Phe Ser Lys Leu Val Thr Ser 
        675                 680                 685             


Gly Leu Gly Thr Val Asp Ala Asp Tyr Lys Lys Cys Thr Lys Gly Leu 
    690                 695                 700                 


Ser Ile Ala Asp Leu Ala Cys Ala Gln Tyr Tyr Asn Gly Ile Met Val 
705                 710                 715                 720 


Leu Pro Gly Val Ala Asp Ala Glu Arg Met Ala Met Tyr Thr Gly Ser 
                725                 730                 735     


Leu Ile Gly Gly Ile Ala Leu Gly Gly Leu Thr Ser Ala Ala Ser Ile 
            740                 745                 750         


Pro Phe Ser Leu Ala Ile Gln Ser Arg Leu Asn Tyr Val Ala Leu Gln 
        755                 760                 765             


Thr Asp Val Leu Gln Glu Asn Gln Lys Ile Leu Ala Ala Ser Phe Asn 
    770                 775                 780                 


Lys Ala Met Thr Asn Ile Val Asp Ala Phe Thr Gly Val Asn Asp Ala 
785                 790                 795                 800 


Ile Thr Gln Thr Ser Gln Ala Leu Gln Thr Val Ala Thr Ala Leu Asn 
                805                 810                 815     


Lys Ile Gln Asp Val Val Asn Gln Gln Gly Asn Ser Leu Asn His Leu 
            820                 825                 830         


Thr Ser Gln Leu Arg Gln Asn Phe Gln Ala Ile Ser Ser Ser Ile Gln 
        835                 840                 845             


Ala Ile Tyr Asp Arg Leu Asp Pro Pro Gln Ala Asp Gln Gln Val Asp 
    850                 855                 860                 


Arg Leu Ile Thr Gly Arg Leu Ala Ala Leu Asn Val Phe Val Ser His 
865                 870                 875                 880 


Thr Leu Thr Lys Tyr Thr Glu Val Arg Ala Ser Arg Gln Leu Ala Gln 
                885                 890                 895     


Gln Lys Val Asn Glu Cys Val Lys Ser Gln Ser Lys Arg Tyr Gly Phe 
            900                 905                 910         


Cys Gly Asn Gly Thr His Ile Phe Ser Leu Val Asn Ala Ala Pro Glu 
        915                 920                 925             


Gly Leu Val Phe Leu His Thr Val Leu Leu Pro Thr Gln Tyr Lys Asp 
    930                 935                 940                 


Val Glu Ala Trp Ser Gly Leu Cys Val Asp Gly Arg Asn Gly Tyr Val 
945                 950                 955                 960 


Leu Arg Gln Pro Asn Leu Ala Leu Tyr Lys Glu Gly Asn Tyr Tyr Arg 
                965                 970                 975     


Ile Thr Ser Arg Ile Met Phe Glu Pro Arg Ile Pro Thr Ile Ala Asp 
            980                 985                 990         


Phe Val Gln Ile Glu Asn Cys Asn  Val Thr Phe Val Asn  Ile Ser Arg 
        995                 1000                 1005             


Ser Glu  Leu Gln Thr Ile Val  Pro Glu Tyr Ile Gly  Asp Leu Asn 
    1010                 1015                 1020             


Lys Thr  Leu Gln Glu Leu Ser  Tyr Lys Leu Pro Asn  Leu Thr Val 
    1025                 1030                 1035             


Lys Gly  Ser Gly Gly Ser Gly  Asp Ile Ile Lys Leu  Leu Asn Glu 
    1040                 1045                 1050             


Gln Val  Asn Lys Glu Met Gln  Ser Ser Asn Leu Tyr  Met Ser Met 
    1055                 1060                 1065             


Ser Ser  Trp Cys Tyr Thr His  Ser Leu Asp Gly Ala  Gly Leu Phe 
    1070                 1075                 1080             


Leu Phe  Asp His Ala Ala Glu  Glu Tyr Glu His Ala  Lys Lys Leu 
    1085                 1090                 1095             


Ile Ile  Phe Leu Asn Glu Asn  Asn Val Pro Val Gln  Leu Thr Ser 
    1100                 1105                 1110             


Ile Ser  Ala Pro Glu His Lys  Phe Glu Gly Leu Thr  Gln Ile Phe 
    1115                 1120                 1125             


Gln Lys  Ala Tyr Glu His Glu  Gln His Ile Ser Glu  Ser Ile Asn 
    1130                 1135                 1140             


Asn Ile  Val Asp His Ala Ile  Lys Ser Lys Asp His  Ala Thr Phe 
    1145                 1150                 1155             


Asn Phe  Leu Gln Trp Tyr Val  Ala Glu Gln His Glu  Glu Glu Val 
    1160                 1165                 1170             


Leu Phe  Lys Asp Ile Leu Asp  Lys Ile Glu Leu Ile  Gly Asn Glu 
    1175                 1180                 1185             


Asn His  Gly Leu Tyr Leu Ala  Asp Gln Tyr Val Lys  Gly Ile Ala 
    1190                 1195                 1200             


Lys Ser  Arg Lys Ser Gly Ser  
    1205                 1210 


<210> 266
<211> 1387
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 266
Cys Asn Ser Asn Ala Asn Leu Ser Met Leu Gln Leu Gly Val Pro Asp 
1               5                   10                  15      


Asn Ser Ser Thr Ile Val Thr Gly Leu Leu Pro Thr His Trp Phe Cys 
            20                  25                  30          


Ala Asn Gln Ser Thr Ser Val Tyr Ser Ala Asn Gly Phe Phe Tyr Ile 
        35                  40                  45              


Asp Val Gly Asn His Arg Ser Ala Phe Ala Leu His Thr Gly Tyr Tyr 
    50                  55                  60                  


Asp Ala Asn Gln Tyr Tyr Ile Tyr Val Thr Asn Glu Ile Gly Leu Asn 
65                  70                  75                  80  


Ala Ser Val Thr Leu Lys Ile Cys Lys Phe Ser Arg Asn Thr Thr Phe 
                85                  90                  95      


Asp Phe Leu Ser Asn Ala Ser Ser Ser Phe Asp Cys Ile Val Asn Leu 
            100                 105                 110         


Leu Phe Thr Glu Gln Leu Gly Ala Pro Leu Gly Ile Thr Ile Ser Gly 
        115                 120                 125             


Glu Thr Val Arg Leu His Leu Tyr Asn Val Thr Arg Thr Phe Tyr Val 
    130                 135                 140                 


Pro Ala Ala Tyr Lys Leu Thr Lys Leu Ser Val Lys Cys Tyr Phe Asn 
145                 150                 155                 160 


Tyr Ser Cys Val Phe Ser Val Val Asn Ala Thr Val Thr Val Asn Val 
                165                 170                 175     


Thr Thr His Asn Gly Arg Val Val Asn Tyr Thr Val Cys Asp Asp Cys 
            180                 185                 190         


Asn Gly Tyr Thr Asp Asn Ile Phe Ser Val Gln Gln Asp Gly Arg Ile 
        195                 200                 205             


Pro Asn Gly Phe Pro Phe Asn Asn Trp Phe Leu Leu Thr Asn Gly Ser 
    210                 215                 220                 


Thr Leu Val Asp Gly Val Ser Arg Leu Tyr Gln Pro Leu Arg Leu Thr 
225                 230                 235                 240 


Cys Leu Trp Pro Val Pro Gly Leu Lys Ser Ser Thr Gly Phe Val Tyr 
                245                 250                 255     


Phe Asn Ala Thr Gly Ser Asp Val Asn Cys Asn Gly Tyr Gln His Asn 
            260                 265                 270         


Ser Val Val Asp Val Met Arg Tyr Asn Leu Asn Phe Ser Ala Asn Ser 
        275                 280                 285             


Leu Asp Asn Leu Lys Ser Gly Val Ile Val Phe Lys Thr Leu Gln Tyr 
    290                 295                 300                 


Asp Val Leu Phe Tyr Cys Ser Asn Ser Ser Ser Gly Val Leu Asp Thr 
305                 310                 315                 320 


Thr Ile Pro Phe Gly Pro Ser Ser Gln Pro Tyr Tyr Cys Phe Ile Asn 
                325                 330                 335     


Ser Thr Ile Asn Thr Thr His Val Ser Thr Phe Val Gly Ile Leu Pro 
            340                 345                 350         


Pro Thr Val Arg Glu Ile Val Val Ala Arg Thr Gly Gln Phe Tyr Ile 
        355                 360                 365             


Asn Gly Phe Lys Tyr Phe Asp Leu Gly Phe Ile Glu Ala Val Asn Phe 
    370                 375                 380                 


Asn Val Thr Thr Ala Ser Ala Thr Asp Phe Trp Thr Val Ala Phe Ala 
385                 390                 395                 400 


Thr Phe Val Asp Val Leu Val Asn Val Ser Ala Thr Asn Ile Gln Asn 
                405                 410                 415     


Leu Leu Tyr Cys Asp Ser Pro Phe Glu Lys Leu Gln Cys Glu His Leu 
            420                 425                 430         


Gln Phe Gly Leu Gln Asp Gly Phe Tyr Ser Ala Asn Phe Leu Asp Asp 
        435                 440                 445             


Asn Val Leu Pro Glu Thr Tyr Val Ala Leu Pro Ile Tyr Tyr Gln His 
    450                 455                 460                 


Thr Asp Ile Asn Phe Thr Ala Thr Ala Ser Phe Gly Gly Ser Cys Tyr 
465                 470                 475                 480 


Val Cys Lys Pro His Gln Val Asn Ile Ser Leu Asn Gly Asn Thr Ser 
                485                 490                 495     


Val Cys Val Arg Thr Ser His Phe Ser Ile Arg Tyr Ile Tyr Asn Arg 
            500                 505                 510         


Val Lys Ser Gly Ser Pro Gly Asp Ser Ser Trp His Ile Tyr Leu Lys 
        515                 520                 525             


Ser Gly Thr Cys Pro Phe Ser Phe Ser Lys Leu Asn Asn Phe Gln Lys 
    530                 535                 540                 


Phe Lys Thr Ile Cys Phe Ser Thr Val Glu Val Pro Gly Ser Cys Asn 
545                 550                 555                 560 


Phe Pro Leu Glu Ala Thr Trp His Tyr Thr Ser Tyr Thr Ile Val Gly 
                565                 570                 575     


Ala Leu Tyr Val Thr Trp Ser Glu Gly Asn Ser Ile Thr Gly Val Pro 
            580                 585                 590         


Tyr Pro Val Ser Gly Ile Arg Glu Phe Ser Asn Leu Val Leu Asn Asn 
        595                 600                 605             


Cys Thr Lys Tyr Asn Ile Tyr Asp Tyr Val Gly Thr Gly Ile Ile Arg 
    610                 615                 620                 


Ser Ser Asn Gln Ser Leu Ala Gly Gly Ile Thr Tyr Val Ser Asn Ser 
625                 630                 635                 640 


Gly Asn Leu Leu Gly Phe Lys Asn Val Ser Thr Gly Asn Ile Phe Ile 
                645                 650                 655     


Val Thr Pro Cys Asn Gln Pro Asp Gln Val Ala Val Tyr Gln Gln Ser 
            660                 665                 670         


Ile Ile Gly Ala Met Thr Ala Val Asn Glu Ser Arg Tyr Gly Leu Gln 
        675                 680                 685             


Asn Leu Leu Gln Leu Pro Asn Phe Tyr Tyr Val Ser Asn Gly Gly Asn 
    690                 695                 700                 


Asn Cys Thr Thr Ala Val Met Thr Tyr Ser Asn Phe Gly Ile Cys Ala 
705                 710                 715                 720 


Asp Gly Ser Leu Ile Pro Val Arg Pro Arg Asn Ser Ser Asp Asn Gly 
                725                 730                 735     


Ile Ser Ala Ile Ile Thr Ala Asn Leu Ser Ile Pro Ser Asn Trp Thr 
            740                 745                 750         


Thr Ser Val Gln Val Glu Tyr Leu Gln Ile Thr Ser Thr Pro Ile Val 
        755                 760                 765             


Val Asp Cys Ala Thr Tyr Val Cys Asn Gly Asn Pro Arg Cys Lys Asn 
    770                 775                 780                 


Leu Leu Lys Gln Tyr Thr Ser Ala Cys Lys Thr Ile Glu Asp Ala Leu 
785                 790                 795                 800 


Arg Leu Ser Ala His Leu Glu Thr Asn Asp Val Ser Ser Met Leu Thr 
                805                 810                 815     


Phe Asp Ser Asn Ala Phe Ser Leu Ala Asn Val Thr Ser Phe Gly Asp 
            820                 825                 830         


Tyr Asn Leu Ser Ser Val Leu Pro Gln Arg Asn Ile Arg Ser Ser Arg 
        835                 840                 845             


Ile Ala Gly Arg Ser Ala Leu Glu Asp Leu Leu Phe Ser Lys Val Val 
    850                 855                 860                 


Thr Ser Gly Leu Gly Thr Val Asp Val Asp Tyr Lys Ser Cys Thr Lys 
865                 870                 875                 880 


Gly Leu Ser Ile Ala Asp Leu Ala Cys Ala Gln Tyr Tyr Asn Gly Ile 
                885                 890                 895     


Met Val Leu Pro Gly Val Ala Asp Ala Glu Arg Met Ala Met Tyr Thr 
            900                 905                 910         


Gly Ser Leu Ile Gly Gly Met Val Leu Gly Gly Leu Thr Ser Ala Ala 
        915                 920                 925             


Ala Ile Pro Phe Ser Leu Ala Leu Gln Ala Arg Leu Asn Tyr Val Ala 
    930                 935                 940                 


Leu Gln Thr Asp Val Leu Gln Glu Asn Gln Lys Ile Leu Ala Ala Ser 
945                 950                 955                 960 


Phe Asn Lys Ala Ile Asn Asn Ile Val Ala Ser Phe Ser Ser Val Asn 
                965                 970                 975     


Asp Ala Ile Thr Gln Thr Ala Glu Ala Ile His Thr Val Thr Ile Ala 
            980                 985                 990         


Leu Asn Lys Ile Gln Asp Val Val  Asn Gln Gln Gly Ser  Ala Leu Asn 
        995                 1000                 1005             


His Leu  Thr Ser Gln Leu Arg  His Asn Phe Gln Ala  Ile Ser Asn 
    1010                 1015                 1020             


Ser Ile  Gln Ala Ile Tyr Asp  Arg Leu Asp Pro Pro  Gln Ala Asp 
    1025                 1030                 1035             


Gln Gln  Val Asp Arg Leu Ile  Thr Gly Arg Leu Ala  Ala Leu Asn 
    1040                 1045                 1050             


Ala Phe  Val Ser Gln Val Leu  Asn Lys Tyr Thr Glu  Val Arg Gly 
    1055                 1060                 1065             


Ser Arg  Arg Leu Ala Gln Gln  Lys Ile Asn Glu Cys  Val Lys Ser 
    1070                 1075                 1080             


Gln Ser  Asn Arg Tyr Gly Phe  Cys Gly Asn Gly Thr  His Ile Phe 
    1085                 1090                 1095             


Ser Ile  Val Asn Ser Ala Pro  Asp Gly Leu Leu Phe  Leu His Thr 
    1100                 1105                 1110             


Val Leu  Leu Pro Thr Asp Tyr  Lys Asn Val Lys Ala  Trp Ser Gly 
    1115                 1120                 1125             


Ile Cys  Val Asp Gly Ile Tyr  Gly Tyr Val Leu Arg  Gln Pro Asn 
    1130                 1135                 1140             


Leu Val  Leu Tyr Ser Asp Asn  Gly Val Phe Arg Val  Thr Ser Arg 
    1145                 1150                 1155             


Val Met  Phe Gln Pro Arg Leu  Pro Val Leu Ser Asp  Phe Val Gln 
    1160                 1165                 1170             


Ile Tyr  Asn Cys Asn Val Thr  Phe Val Asn Ile Ser  Arg Val Glu 
    1175                 1180                 1185             


Leu His  Thr Val Ile Pro Asp  Tyr Val Asp Leu Asn  Lys Thr Leu 
    1190                 1195                 1200             


Gln Glu  Leu Ala Gln Asn Leu  Glu Lys Leu Val Lys  Lys Gly Ser 
    1205                 1210                 1215             


Gly Gly  Ser Gly Asp Ile Ile  Lys Leu Leu Asn Glu  Gln Val Asn 
    1220                 1225                 1230             


Lys Glu  Met Gln Ser Ser Asn  Leu Tyr Met Ser Met  Ser Ser Trp 
    1235                 1240                 1245             


Cys Tyr  Thr His Ser Leu Asp  Gly Ala Gly Leu Phe  Leu Phe Asp 
    1250                 1255                 1260             


His Ala  Ala Glu Glu Tyr Glu  His Ala Lys Lys Leu  Ile Ile Phe 
    1265                 1270                 1275             


Leu Asn  Glu Asn Asn Val Pro  Val Gln Leu Thr Ser  Ile Ser Ala 
    1280                 1285                 1290             


Pro Glu  His Lys Phe Glu Gly  Leu Thr Gln Ile Phe  Gln Lys Ala 
    1295                 1300                 1305             


Tyr Glu  His Glu Gln His Ile  Ser Glu Ser Ile Asn  Asn Ile Val 
    1310                 1315                 1320             


Asp His  Ala Ile Lys Ser Lys  Asp His Ala Thr Phe  Asn Phe Leu 
    1325                 1330                 1335             


Gln Trp  Tyr Val Ala Glu Gln  His Glu Glu Glu Val  Leu Phe Lys 
    1340                 1345                 1350             


Asp Ile  Leu Asp Lys Ile Glu  Leu Ile Gly Asn Glu  Asn His Gly 
    1355                 1360                 1365             


Leu Tyr  Leu Ala Asp Gln Tyr  Val Lys Gly Ile Ala  Lys Ser Arg 
    1370                 1375                 1380             


Lys Ser  Gly Ser 
    1385         


<210> 267
<211> 1388
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 267
Cys Asn Ser Asn Ala Asn Leu Ser Met Leu Gln Leu Gly Val Pro Asp 
1               5                   10                  15      


Asn Ser Ser Thr Ile Val Thr Gly Leu Leu Pro Thr His Trp Phe Cys 
            20                  25                  30          


Ala Asn Gln Ser Thr Ser Val Tyr Ser Ala Asn Gly Phe Phe Tyr Ile 
        35                  40                  45              


Asp Val Gly Asn His Arg Ser Ala Phe Ala Leu His Thr Gly Tyr Tyr 
    50                  55                  60                  


Asp Ala Asn Gln Tyr Tyr Ile Tyr Val Thr Asn Glu Ile Gly Leu Asn 
65                  70                  75                  80  


Ala Ser Val Thr Leu Lys Ile Cys Lys Phe Ser Arg Asn Thr Thr Phe 
                85                  90                  95      


Asp Phe Leu Ser Asn Ala Ser Ser Ser Phe Asp Cys Ile Val Asn Leu 
            100                 105                 110         


Leu Phe Thr Glu Gln Leu Gly Ala Pro Leu Gly Ile Thr Ile Ser Gly 
        115                 120                 125             


Glu Thr Val Arg Leu His Leu Tyr Asn Val Thr Arg Thr Phe Tyr Val 
    130                 135                 140                 


Pro Ala Ala Tyr Lys Leu Thr Lys Leu Ser Val Lys Cys Tyr Phe Asn 
145                 150                 155                 160 


Tyr Ser Cys Val Phe Ser Val Val Asn Ala Thr Val Thr Val Asn Val 
                165                 170                 175     


Thr Thr His Asn Gly Arg Val Val Asn Tyr Thr Val Cys Asp Asp Cys 
            180                 185                 190         


Asn Gly Tyr Thr Asp Asn Ile Phe Ser Val Gln Gln Asp Gly Arg Ile 
        195                 200                 205             


Pro Asn Gly Phe Pro Phe Asn Asn Trp Phe Leu Leu Thr Asn Gly Ser 
    210                 215                 220                 


Thr Leu Val Asp Gly Val Ser Arg Leu Tyr Gln Pro Leu Arg Leu Thr 
225                 230                 235                 240 


Cys Leu Trp Pro Val Pro Gly Leu Lys Ser Ser Thr Gly Phe Val Tyr 
                245                 250                 255     


Phe Asn Ala Thr Gly Ser Asp Val Asn Cys Asn Gly Tyr Gln His Asn 
            260                 265                 270         


Ser Val Val Asp Val Met Arg Tyr Asn Leu Asn Phe Ser Ala Asn Ser 
        275                 280                 285             


Leu Asp Asn Leu Lys Ser Gly Val Ile Val Phe Lys Thr Leu Gln Tyr 
    290                 295                 300                 


Asp Val Leu Phe Tyr Cys Ser Asn Ser Ser Ser Gly Val Leu Asp Thr 
305                 310                 315                 320 


Thr Ile Pro Phe Gly Pro Ser Ser Gln Pro Tyr Tyr Cys Phe Ile Asn 
                325                 330                 335     


Ser Thr Ile Asn Thr Thr His Val Ser Thr Phe Val Gly Ile Leu Pro 
            340                 345                 350         


Pro Thr Val Arg Glu Ile Val Val Ala Arg Thr Gly Gln Phe Tyr Ile 
        355                 360                 365             


Asn Gly Phe Lys Tyr Phe Asp Leu Gly Phe Ile Glu Ala Val Asn Phe 
    370                 375                 380                 


Asn Val Thr Thr Ala Ser Ala Thr Asp Phe Trp Thr Val Ala Phe Ala 
385                 390                 395                 400 


Thr Phe Val Asp Val Leu Val Asn Val Ser Ala Thr Asn Ile Gln Asn 
                405                 410                 415     


Leu Leu Tyr Cys Asp Ser Pro Phe Glu Lys Leu Gln Cys Glu His Leu 
            420                 425                 430         


Gln Phe Gly Leu Gln Asp Gly Phe Tyr Ser Ala Asn Phe Leu Asp Asp 
        435                 440                 445             


Asn Val Leu Pro Glu Thr Tyr Val Ala Leu Pro Ile Tyr Tyr Gln His 
    450                 455                 460                 


Thr Asp Ile Asn Phe Thr Ala Thr Ala Ser Phe Gly Gly Ser Cys Tyr 
465                 470                 475                 480 


Val Cys Lys Pro His Gln Val Asn Ile Ser Leu Asn Gly Asn Thr Ser 
                485                 490                 495     


Val Cys Val Arg Thr Ser His Phe Ser Ile Arg Tyr Ile Tyr Asn Arg 
            500                 505                 510         


Val Lys Ser Gly Ser Pro Gly Asp Ser Ser Trp His Ile Tyr Leu Lys 
        515                 520                 525             


Ser Gly Thr Cys Pro Phe Ser Phe Ser Lys Leu Asn Asn Phe Gln Lys 
    530                 535                 540                 


Phe Lys Thr Ile Cys Phe Ser Thr Val Glu Val Pro Gly Ser Cys Asn 
545                 550                 555                 560 


Phe Pro Leu Glu Ala Thr Trp His Tyr Thr Ser Tyr Thr Ile Val Gly 
                565                 570                 575     


Ala Leu Tyr Val Thr Trp Ser Glu Gly Asn Ser Ile Thr Gly Val Pro 
            580                 585                 590         


Tyr Pro Val Ser Gly Ile Arg Glu Phe Ser Asn Leu Val Leu Asn Asn 
        595                 600                 605             


Cys Thr Lys Tyr Asn Ile Tyr Asp Tyr Val Gly Thr Gly Ile Ile Arg 
    610                 615                 620                 


Ser Ser Asn Gln Ser Leu Ala Gly Gly Ile Thr Tyr Val Ser Asn Ser 
625                 630                 635                 640 


Gly Asn Leu Leu Gly Phe Lys Asn Val Ser Thr Gly Asn Ile Phe Ile 
                645                 650                 655     


Val Thr Pro Cys Asn Gln Pro Asp Gln Val Ala Val Tyr Gln Gln Ser 
            660                 665                 670         


Ile Ile Gly Ala Met Thr Ala Val Asn Glu Ser Arg Tyr Gly Leu Gln 
        675                 680                 685             


Asn Leu Leu Gln Leu Pro Asn Phe Tyr Tyr Val Ser Asn Gly Gly Asn 
    690                 695                 700                 


Asn Cys Thr Thr Ala Val Met Thr Tyr Ser Asn Phe Gly Ile Cys Ala 
705                 710                 715                 720 


Asp Gly Ser Leu Ile Pro Val Arg Pro Arg Asn Ser Ser Asp Asn Gly 
                725                 730                 735     


Ile Ser Ala Ile Ile Thr Ala Asn Leu Ser Ile Pro Ser Asn Trp Thr 
            740                 745                 750         


Thr Ser Val Gln Val Glu Tyr Leu Gln Ile Thr Ser Thr Pro Ile Val 
        755                 760                 765             


Val Asp Cys Ala Thr Tyr Val Cys Asn Gly Asn Pro Arg Cys Lys Asn 
    770                 775                 780                 


Leu Leu Lys Gln Tyr Thr Ser Ala Cys Lys Thr Ile Glu Asp Ala Leu 
785                 790                 795                 800 


Arg Leu Ser Ala His Leu Glu Thr Asn Asp Val Ser Ser Met Leu Thr 
                805                 810                 815     


Phe Asp Ser Asn Ala Phe Ser Leu Ala Asn Val Thr Ser Phe Gly Asp 
            820                 825                 830         


Tyr Asn Leu Ser Ser Val Leu Pro Gln Arg Asn Ile Arg Ser Ser Arg 
        835                 840                 845             


Ile Ala Gly Arg Ser Ala Leu Glu Asp Leu Leu Phe Ser Lys Val Val 
    850                 855                 860                 


Thr Ser Gly Leu Gly Thr Val Asp Val Asp Tyr Lys Ser Cys Thr Lys 
865                 870                 875                 880 


Gly Leu Ser Ile Ala Asp Leu Ala Cys Ala Gln Tyr Tyr Asn Gly Ile 
                885                 890                 895     


Met Val Leu Pro Gly Val Ala Asp Ala Glu Arg Met Ala Met Tyr Thr 
            900                 905                 910         


Gly Ser Leu Ile Gly Gly Met Val Leu Gly Gly Leu Thr Ser Ala Ala 
        915                 920                 925             


Ala Ile Pro Phe Ser Leu Ala Leu Gln Ala Arg Leu Asn Tyr Val Ala 
    930                 935                 940                 


Leu Gln Thr Asp Val Leu Gln Glu Asn Gln Lys Ile Leu Ala Ala Ser 
945                 950                 955                 960 


Phe Asn Lys Ala Ile Asn Asn Ile Val Ala Ser Phe Ser Ser Val Asn 
                965                 970                 975     


Asp Ala Ile Thr Gln Thr Ala Glu Ala Ile His Thr Val Thr Ile Ala 
            980                 985                 990         


Leu Asn Lys Ile Gln Asp Val Val  Asn Gln Gln Gly Ser  Ala Leu Asn 
        995                 1000                 1005             


His Leu  Thr Ser Gln Leu Arg  His Asn Phe Gln Ala  Ile Ser Asn 
    1010                 1015                 1020             


Ser Ile  Gln Ala Ile Tyr Asp  Arg Leu Asp Pro Pro  Gln Ala Asp 
    1025                 1030                 1035             


Gln Gln  Val Asp Arg Leu Ile  Thr Gly Arg Leu Ala  Ala Leu Asn 
    1040                 1045                 1050             


Ala Phe  Val Ser Gln Val Leu  Asn Lys Tyr Thr Glu  Val Arg Gly 
    1055                 1060                 1065             


Ser Arg  Arg Leu Ala Gln Gln  Lys Ile Asn Glu Cys  Val Lys Ser 
    1070                 1075                 1080             


Gln Ser  Asn Arg Tyr Gly Phe  Cys Gly Asn Gly Thr  His Ile Phe 
    1085                 1090                 1095             


Ser Ile  Val Asn Ser Ala Pro  Asp Gly Leu Leu Phe  Leu His Thr 
    1100                 1105                 1110             


Val Leu  Leu Pro Thr Asp Tyr  Lys Asn Val Lys Ala  Trp Ser Gly 
    1115                 1120                 1125             


Ile Cys  Val Asp Gly Ile Tyr  Gly Tyr Val Leu Arg  Gln Pro Asn 
    1130                 1135                 1140             


Leu Val  Leu Tyr Ser Asp Asn  Gly Val Phe Arg Val  Thr Ser Arg 
    1145                 1150                 1155             


Val Met  Phe Gln Pro Arg Leu  Pro Val Leu Ser Asp  Phe Val Gln 
    1160                 1165                 1170             


Ile Tyr  Asn Cys Asn Val Thr  Phe Val Asn Ile Ser  Arg Val Glu 
    1175                 1180                 1185             


Leu His  Thr Val Ile Pro Asp  Tyr Ile Gly Asp Leu  Asn Lys Thr 
    1190                 1195                 1200             


Leu Gln  Glu Leu Ala Gln Asn  Leu Glu Lys Leu Val  Lys Lys Gly 
    1205                 1210                 1215             


Ser Gly  Gly Ser Gly Asp Ile  Ile Lys Leu Leu Asn  Glu Gln Val 
    1220                 1225                 1230             


Asn Lys  Glu Met Gln Ser Ser  Asn Leu Tyr Met Ser  Met Ser Ser 
    1235                 1240                 1245             


Trp Cys  Tyr Thr His Ser Leu  Asp Gly Ala Gly Leu  Phe Leu Phe 
    1250                 1255                 1260             


Asp His  Ala Ala Glu Glu Tyr  Glu His Ala Lys Lys  Leu Ile Ile 
    1265                 1270                 1275             


Phe Leu  Asn Glu Asn Asn Val  Pro Val Gln Leu Thr  Ser Ile Ser 
    1280                 1285                 1290             


Ala Pro  Glu His Lys Phe Glu  Gly Leu Thr Gln Ile  Phe Gln Lys 
    1295                 1300                 1305             


Ala Tyr  Glu His Glu Gln His  Ile Ser Glu Ser Ile  Asn Asn Ile 
    1310                 1315                 1320             


Val Asp  His Ala Ile Lys Ser  Lys Asp His Ala Thr  Phe Asn Phe 
    1325                 1330                 1335             


Leu Gln  Trp Tyr Val Ala Glu  Gln His Glu Glu Glu  Val Leu Phe 
    1340                 1345                 1350             


Lys Asp  Ile Leu Asp Lys Ile  Glu Leu Ile Gly Asn  Glu Asn His 
    1355                 1360                 1365             


Gly Leu  Tyr Leu Ala Asp Gln  Tyr Val Lys Gly Ile  Ala Lys Ser 
    1370                 1375                 1380             


Arg Lys  Ser Gly Ser 
    1385             


<210> 268
<211> 1398
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 268
Val Ile Gly Asp Phe Asn Cys Thr Asn Ser Phe Ile Asn Asp Tyr Asn 
1               5                   10                  15      


Lys Thr Ile Pro Arg Ile Ser Glu Asp Val Val Asp Val Ser Leu Gly 
            20                  25                  30          


Leu Gly Thr Tyr Tyr Val Leu Asn Arg Val Tyr Leu Asn Thr Thr Leu 
        35                  40                  45              


Leu Phe Thr Gly Tyr Phe Pro Lys Ser Gly Ala Asn Phe Arg Asp Leu 
    50                  55                  60                  


Ala Leu Lys Gly Ser Ile Tyr Leu Ser Thr Leu Trp Tyr Lys Pro Pro 
65                  70                  75                  80  


Phe Leu Ser Asp Phe Asn Asn Gly Ile Phe Ser Lys Val Lys Asn Thr 
                85                  90                  95      


Lys Leu Tyr Val Asn Asn Thr Leu Tyr Ser Glu Phe Ser Thr Ile Val 
            100                 105                 110         


Ile Gly Ser Val Phe Val Asn Thr Ser Tyr Thr Ile Val Val Gln Pro 
        115                 120                 125             


His Asn Gly Ile Leu Glu Ile Thr Ala Cys Gln Tyr Thr Met Cys Glu 
    130                 135                 140                 


Tyr Pro His Thr Val Cys Lys Ser Lys Gly Ser Ile Arg Asn Glu Ser 
145                 150                 155                 160 


Trp His Ile Asp Ser Ser Glu Pro Leu Cys Leu Phe Lys Lys Asn Phe 
                165                 170                 175     


Thr Tyr Asn Val Ser Ala Asp Trp Leu Tyr Phe His Phe Tyr Gln Glu 
            180                 185                 190         


Arg Gly Val Phe Tyr Ala Tyr Tyr Ala Asp Val Gly Met Pro Thr Thr 
        195                 200                 205             


Phe Leu Phe Ser Leu Tyr Leu Gly Thr Ile Leu Ser His Tyr Tyr Val 
    210                 215                 220                 


Met Pro Leu Thr Cys Asn Ala Ile Ser Ser Asn Thr Asp Asn Glu Thr 
225                 230                 235                 240 


Leu Glu Tyr Trp Val Thr Pro Leu Ser Arg Arg Gln Tyr Leu Leu Asn 
                245                 250                 255     


Phe Asp Glu His Gly Val Ile Thr Asn Ala Val Asp Cys Ser Ser Ser 
            260                 265                 270         


Phe Leu Ser Glu Ile Gln Cys Lys Thr Gln Ser Phe Ala Pro Asn Thr 
        275                 280                 285             


Gly Val Tyr Asp Leu Ser Gly Phe Thr Val Lys Pro Val Ala Thr Val 
    290                 295                 300                 


Tyr Arg Arg Ile Pro Asn Leu Pro Asp Cys Asp Ile Asp Asn Trp Leu 
305                 310                 315                 320 


Asn Asn Val Ser Val Pro Ser Pro Leu Asn Trp Glu Arg Arg Ile Phe 
                325                 330                 335     


Ser Asn Cys Asn Phe Asn Leu Ser Thr Leu Leu Arg Leu Val His Val 
            340                 345                 350         


Asp Ser Phe Ser Cys Asn Asn Leu Asp Lys Ser Lys Ile Phe Gly Ser 
        355                 360                 365             


Cys Phe Asn Ser Ile Thr Val Asp Lys Phe Ala Ile Pro Asn Arg Arg 
    370                 375                 380                 


Arg Asp Asp Leu Gln Leu Gly Ser Ser Gly Phe Leu Gln Ser Ser Asn 
385                 390                 395                 400 


Tyr Lys Ile Asp Ile Ser Ser Ser Ser Cys Gln Leu Tyr Tyr Ser Leu 
                405                 410                 415     


Pro Leu Val Asn Val Thr Ile Asn Asn Phe Asn Pro Ser Ser Trp Asn 
            420                 425                 430         


Arg Arg Tyr Gly Phe Gly Ser Phe Asn Leu Ser Ser Tyr Asp Val Val 
        435                 440                 445             


Tyr Ser Asp His Cys Phe Ser Val Asn Ser Asp Phe Cys Pro Cys Ala 
    450                 455                 460                 


Asp Pro Ser Val Val Asn Ser Cys Ala Lys Ser Lys Pro Pro Ser Ala 
465                 470                 475                 480 


Ile Cys Pro Ala Gly Thr Lys Tyr Arg His Cys Asp Leu Asp Thr Thr 
                485                 490                 495     


Leu Tyr Val Lys Asn Trp Cys Arg Cys Ser Cys Leu Pro Asp Pro Ile 
            500                 505                 510         


Ser Thr Tyr Ser Pro Asn Thr Cys Pro Gln Lys Lys Val Val Val Gly 
        515                 520                 525             


Ile Gly Glu His Cys Pro Gly Leu Gly Ile Asn Glu Glu Lys Cys Gly 
    530                 535                 540                 


Thr Gln Leu Asn His Ser Ser Cys Phe Cys Ser Pro Asp Ala Phe Leu 
545                 550                 555                 560 


Gly Trp Ser Phe Asp Ser Cys Ile Ser Asn Asn Arg Cys Asn Ile Phe 
                565                 570                 575     


Ser Asn Phe Ile Phe Asn Gly Ile Asn Ser Gly Thr Thr Cys Ser Asn 
            580                 585                 590         


Asp Leu Leu Tyr Ser Asn Thr Glu Ile Ser Thr Gly Val Cys Val Asn 
        595                 600                 605             


Tyr Asp Leu Tyr Gly Ile Thr Gly Gln Gly Ile Phe Lys Glu Val Ser 
    610                 615                 620                 


Ala Ala Tyr Tyr Asn Asn Trp Gln Asn Leu Leu Tyr Asp Ser Asn Gly 
625                 630                 635                 640 


Asn Ile Ile Gly Phe Lys Asp Phe Leu Thr Asn Lys Thr Tyr Thr Ile 
                645                 650                 655     


Leu Pro Cys Tyr Ser Gly Arg Val Ser Ala Ala Phe Tyr Gln Asn Ser 
            660                 665                 670         


Ser Ser Pro Ala Leu Leu Tyr Arg Asn Leu Lys Cys Ser Tyr Val Leu 
        675                 680                 685             


Asn Asn Ile Ser Phe Ile Ser Gln Pro Phe Tyr Phe Asp Ser Tyr Leu 
    690                 695                 700                 


Gly Cys Val Leu Asn Ala Val Asn Leu Thr Ser Tyr Ser Val Ser Ser 
705                 710                 715                 720 


Cys Asp Leu Arg Met Gly Ser Gly Phe Cys Ile Asp Tyr Ala Leu Pro 
                725                 730                 735     


Ser Ser Gly Gly Ser Gly Ser Gly Ile Ser Ser Pro Tyr Arg Phe Val 
            740                 745                 750         


Thr Phe Glu Pro Phe Asn Val Ser Phe Val Asn Asp Ser Val Glu Thr 
        755                 760                 765             


Val Gly Gly Leu Phe Glu Ile Gln Ile Pro Thr Asn Phe Thr Ile Ala 
    770                 775                 780                 


Gly His Glu Glu Phe Ile Gln Thr Ser Ser Pro Lys Val Thr Ile Asp 
785                 790                 795                 800 


Cys Ser Ala Phe Val Cys Ser Asn Tyr Ala Ala Cys His Asp Leu Leu 
                805                 810                 815     


Ser Glu Tyr Gly Thr Phe Cys Asp Asn Ile Asn Ser Ile Leu Asn Glu 
            820                 825                 830         


Val Asn Asp Leu Leu Asp Ile Thr Gln Leu Gln Val Ala Asn Ala Leu 
        835                 840                 845             


Met Gln Gly Val Thr Leu Ser Ser Asn Leu Asn Thr Asn Leu His Ser 
    850                 855                 860                 


Asp Val Asp Asn Ile Asp Phe Lys Ser Leu Leu Gly Cys Leu Gly Ser 
865                 870                 875                 880 


Gln Cys Gly Ser Ser Ser Arg Ser Leu Leu Glu Asp Leu Leu Phe Asn 
                885                 890                 895     


Lys Val Lys Leu Ser Asp Val Gly Phe Val Glu Ala Tyr Asn Asn Cys 
            900                 905                 910         


Thr Gly Gly Ser Glu Ile Arg Asp Leu Leu Cys Val Gln Ser Phe Asn 
        915                 920                 925             


Gly Ile Lys Val Leu Pro Pro Ile Leu Ser Glu Thr Gln Ile Ser Gly 
    930                 935                 940                 


Tyr Thr Thr Ala Ala Thr Val Ala Ala Met Phe Pro Pro Trp Ser Ala 
945                 950                 955                 960 


Ala Ala Gly Val Pro Phe Ser Leu Asn Val Gln Tyr Arg Ile Asn Gly 
                965                 970                 975     


Leu Gly Val Thr Met Asp Val Leu Asn Lys Asn Gln Lys Leu Ile Ala 
            980                 985                 990         


Asn Ala Phe Asn Lys Ala Leu Leu  Ser Ile Gln Asn Gly  Phe Thr Ala 
        995                 1000                 1005             


Thr Asn  Ser Ala Leu Ala Lys  Ile Gln Ser Val Val  Asn Ala Asn 
    1010                 1015                 1020             


Ala Gln  Ala Leu Asn Ser Leu  Leu Gln Gln Leu Phe  Asn Lys Phe 
    1025                 1030                 1035             


Gly Ala  Ile Ser Ser Ser Leu  Gln Glu Ile Leu Ser  Arg Leu Asp 
    1040                 1045                 1050             


Pro Pro  Glu Ala Gln Val Gln  Ile Asp Arg Leu Ile  Asn Gly Arg 
    1055                 1060                 1065             


Leu Thr  Ala Leu Asn Ala Tyr  Val Ser Gln Gln Leu  Ser Asp Ile 
    1070                 1075                 1080             


Thr Leu  Ile Lys Ala Gly Ala  Ser Arg Ala Ile Glu  Lys Val Asn 
    1085                 1090                 1095             


Glu Cys  Val Lys Ser Gln Ser  Pro Arg Ile Asn Phe  Cys Gly Asn 
    1100                 1105                 1110             


Gly Asn  His Ile Leu Ser Leu  Val Gln Asn Ala Pro  Tyr Gly Leu 
    1115                 1120                 1125             


Leu Phe  Ile His Phe Ser Tyr  Lys Pro Thr Ser Phe  Lys Thr Val 
    1130                 1135                 1140             


Leu Val  Ser Pro Gly Leu Cys  Leu Ser Gly Asp Arg  Gly Ile Ala 
    1145                 1150                 1155             


Pro Lys  Gln Gly Tyr Phe Ile  Lys Gln Asn Asp Ser  Trp Met Phe 
    1160                 1165                 1170             


Thr Gly  Ser Ser Tyr Tyr Tyr  Pro Glu Pro Ile Ser  Asp Lys Asn 
    1175                 1180                 1185             


Val Val  Phe Met Asn Ser Cys  Ser Val Asn Phe Thr  Lys Ala Pro 
    1190                 1195                 1200             


Phe Ile  Tyr Leu Asn Asn Ser  Ile Ser Glu Leu Ser  Asp Phe Glu 
    1205                 1210                 1215             


Ala Glu  Leu Ser Gln Trp His  Lys Asn Gly Ser Gly  Gly Ser Gly 
    1220                 1225                 1230             


Asp Ile  Ile Lys Leu Leu Asn  Glu Gln Val Asn Lys  Glu Met Gln 
    1235                 1240                 1245             


Ser Ser  Asn Leu Tyr Met Ser  Met Ser Ser Trp Cys  Tyr Thr His 
    1250                 1255                 1260             


Ser Leu  Asp Gly Ala Gly Leu  Phe Leu Phe Asp His  Ala Ala Glu 
    1265                 1270                 1275             


Glu Tyr  Glu His Ala Lys Lys  Leu Ile Ile Phe Leu  Asn Glu Asn 
    1280                 1285                 1290             


Asn Val  Pro Val Gln Leu Thr  Ser Ile Ser Ala Pro  Glu His Lys 
    1295                 1300                 1305             


Phe Glu  Gly Leu Thr Gln Ile  Phe Gln Lys Ala Tyr  Glu His Glu 
    1310                 1315                 1320             


Gln His  Ile Ser Glu Ser Ile  Asn Asn Ile Val Asp  His Ala Ile 
    1325                 1330                 1335             


Lys Ser  Lys Asp His Ala Thr  Phe Asn Phe Leu Gln  Trp Tyr Val 
    1340                 1345                 1350             


Ala Glu  Gln His Glu Glu Glu  Val Leu Phe Lys Asp  Ile Leu Asp 
    1355                 1360                 1365             


Lys Ile  Glu Leu Ile Gly Asn  Glu Asn His Gly Leu  Tyr Leu Ala 
    1370                 1375                 1380             


Asp Gln  Tyr Val Lys Gly Ile  Ala Lys Ser Arg Lys  Ser Gly Ser 
    1385                 1390                 1395             


<210> 269
<211> 1398
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 269
Val Ile Gly Asp Phe Asn Cys Thr Asn Ser Phe Ile Asn Asp Tyr Asn 
1               5                   10                  15      


Lys Thr Ile Pro Arg Ile Ser Glu Asp Val Val Asp Val Ser Leu Gly 
            20                  25                  30          


Leu Gly Thr Tyr Tyr Val Leu Asn Arg Val Tyr Leu Asn Thr Thr Leu 
        35                  40                  45              


Leu Phe Thr Gly Tyr Phe Pro Lys Ser Gly Ala Asn Phe Arg Asp Leu 
    50                  55                  60                  


Ala Leu Lys Gly Ser Ile Tyr Leu Ser Thr Leu Trp Tyr Lys Pro Pro 
65                  70                  75                  80  


Phe Leu Ser Asp Phe Asn Asn Gly Ile Phe Ser Lys Val Lys Asn Thr 
                85                  90                  95      


Lys Leu Tyr Val Asn Asn Thr Leu Tyr Ser Glu Phe Ser Thr Ile Val 
            100                 105                 110         


Ile Gly Ser Val Phe Val Asn Thr Ser Tyr Thr Ile Val Val Gln Pro 
        115                 120                 125             


His Asn Gly Ile Leu Glu Ile Thr Ala Cys Gln Tyr Thr Met Cys Glu 
    130                 135                 140                 


Tyr Pro His Thr Val Cys Lys Ser Lys Gly Ser Ile Arg Asn Glu Ser 
145                 150                 155                 160 


Trp His Ile Asp Ser Ser Glu Pro Leu Cys Leu Phe Lys Lys Asn Phe 
                165                 170                 175     


Thr Tyr Asn Val Ser Ala Asp Trp Leu Tyr Phe His Phe Tyr Gln Glu 
            180                 185                 190         


Arg Gly Val Phe Tyr Ala Tyr Tyr Ala Asp Val Gly Met Pro Thr Thr 
        195                 200                 205             


Phe Leu Phe Ser Leu Tyr Leu Gly Thr Ile Leu Ser His Tyr Tyr Val 
    210                 215                 220                 


Met Pro Leu Thr Cys Asn Ala Ile Ser Ser Asn Thr Asp Asn Glu Thr 
225                 230                 235                 240 


Leu Glu Tyr Trp Val Thr Pro Leu Ser Arg Arg Gln Tyr Leu Leu Asn 
                245                 250                 255     


Phe Asp Glu His Gly Val Ile Thr Asn Ala Val Asp Cys Ser Ser Ser 
            260                 265                 270         


Phe Leu Ser Glu Ile Gln Cys Lys Thr Gln Ser Phe Ala Pro Asn Thr 
        275                 280                 285             


Gly Val Tyr Asp Leu Ser Gly Phe Thr Val Lys Pro Val Ala Thr Val 
    290                 295                 300                 


Tyr Arg Arg Ile Pro Asn Leu Pro Asp Cys Asp Ile Asp Asn Trp Leu 
305                 310                 315                 320 


Asn Asn Val Ser Val Pro Ser Pro Leu Asn Trp Glu Arg Arg Ile Phe 
                325                 330                 335     


Ser Asn Cys Asn Phe Asn Leu Ser Thr Leu Leu Arg Leu Val His Val 
            340                 345                 350         


Asp Ser Phe Ser Cys Asn Asn Leu Asp Lys Ser Lys Ile Phe Gly Ser 
        355                 360                 365             


Cys Phe Asn Ser Ile Thr Val Asp Lys Phe Ala Ile Pro Asn Arg Arg 
    370                 375                 380                 


Arg Asp Asp Leu Gln Leu Gly Ser Ser Gly Phe Leu Gln Ser Ser Asn 
385                 390                 395                 400 


Tyr Lys Ile Asp Ile Ser Ser Ser Ser Cys Gln Leu Tyr Tyr Ser Leu 
                405                 410                 415     


Pro Leu Val Asn Val Thr Ile Asn Asn Phe Asn Pro Ser Ser Trp Asn 
            420                 425                 430         


Arg Arg Tyr Gly Phe Gly Ser Phe Asn Leu Ser Ser Tyr Asp Val Val 
        435                 440                 445             


Tyr Ser Asp His Cys Phe Ser Val Asn Ser Asp Phe Cys Pro Cys Ala 
    450                 455                 460                 


Asp Pro Ser Val Val Asn Ser Cys Ala Lys Ser Lys Pro Pro Ser Ala 
465                 470                 475                 480 


Ile Cys Pro Ala Gly Thr Lys Tyr Arg His Cys Asp Leu Asp Thr Thr 
                485                 490                 495     


Leu Tyr Val Lys Asn Trp Cys Arg Cys Ser Cys Leu Pro Asp Pro Ile 
            500                 505                 510         


Ser Thr Tyr Ser Pro Asn Thr Cys Pro Gln Lys Lys Val Val Val Gly 
        515                 520                 525             


Ile Gly Glu His Cys Pro Gly Leu Gly Ile Asn Glu Glu Lys Cys Gly 
    530                 535                 540                 


Thr Gln Leu Asn His Ser Ser Cys Phe Cys Ser Pro Asp Ala Phe Leu 
545                 550                 555                 560 


Gly Trp Ser Phe Asp Ser Cys Ile Ser Asn Asn Arg Cys Asn Ile Phe 
                565                 570                 575     


Ser Asn Phe Ile Phe Asn Gly Ile Asn Ser Gly Thr Thr Cys Ser Asn 
            580                 585                 590         


Asp Leu Leu Tyr Ser Asn Thr Glu Ile Ser Thr Gly Val Cys Val Asn 
        595                 600                 605             


Tyr Asp Leu Tyr Gly Ile Thr Gly Gln Gly Ile Phe Lys Glu Val Ser 
    610                 615                 620                 


Ala Ala Tyr Tyr Asn Asn Trp Gln Asn Leu Leu Tyr Asp Ser Asn Gly 
625                 630                 635                 640 


Asn Ile Ile Gly Phe Lys Asp Phe Leu Thr Asn Lys Thr Tyr Thr Ile 
                645                 650                 655     


Leu Pro Cys Tyr Ser Gly Arg Val Ser Ala Ala Phe Tyr Gln Asn Ser 
            660                 665                 670         


Ser Ser Pro Ala Leu Leu Tyr Arg Asn Leu Lys Cys Ser Tyr Val Leu 
        675                 680                 685             


Asn Asn Ile Ser Phe Ile Ser Gln Pro Phe Tyr Phe Asp Ser Tyr Leu 
    690                 695                 700                 


Gly Cys Val Leu Asn Ala Val Asn Leu Thr Ser Tyr Ser Val Ser Ser 
705                 710                 715                 720 


Cys Asp Leu Arg Met Gly Ser Gly Phe Cys Ile Asp Tyr Ala Leu Pro 
                725                 730                 735     


Ser Ser Gly Gly Ser Gly Ser Gly Ile Ser Ser Pro Tyr Arg Phe Val 
            740                 745                 750         


Thr Phe Glu Pro Phe Asn Val Ser Phe Val Asn Asp Ser Val Glu Thr 
        755                 760                 765             


Val Gly Gly Leu Phe Glu Ile Gln Ile Pro Thr Asn Phe Thr Ile Ala 
    770                 775                 780                 


Gly His Glu Glu Phe Ile Gln Thr Ser Ser Pro Lys Val Thr Ile Asp 
785                 790                 795                 800 


Cys Ser Ala Phe Val Cys Ser Asn Tyr Ala Ala Cys His Asp Leu Leu 
                805                 810                 815     


Ser Glu Tyr Gly Thr Phe Cys Asp Asn Ile Asn Ser Ile Leu Asn Glu 
            820                 825                 830         


Val Asn Asp Leu Leu Asp Ile Thr Gln Leu Gln Val Ala Asn Ala Leu 
        835                 840                 845             


Met Gln Gly Val Thr Leu Ser Ser Asn Leu Asn Thr Asn Leu His Ser 
    850                 855                 860                 


Asp Val Asp Asn Ile Asp Phe Lys Ser Leu Leu Gly Cys Leu Gly Ser 
865                 870                 875                 880 


Gln Cys Gly Ser Ser Ser Arg Ser Leu Leu Glu Asp Leu Leu Phe Asn 
                885                 890                 895     


Lys Val Lys Leu Ser Asp Val Gly Phe Val Glu Ala Tyr Asn Asn Cys 
            900                 905                 910         


Thr Gly Gly Ser Glu Ile Arg Asp Leu Leu Cys Val Gln Ser Phe Asn 
        915                 920                 925             


Gly Ile Lys Val Leu Pro Pro Ile Leu Ser Glu Thr Gln Ile Ser Gly 
    930                 935                 940                 


Tyr Thr Thr Ala Ala Thr Val Ala Ala Met Phe Pro Pro Trp Ser Ala 
945                 950                 955                 960 


Ala Ala Gly Val Pro Phe Ser Leu Asn Val Gln Tyr Arg Ile Asn Gly 
                965                 970                 975     


Leu Gly Val Thr Met Asp Val Leu Asn Lys Asn Gln Lys Leu Ile Ala 
            980                 985                 990         


Asn Ala Phe Asn Lys Ala Leu Leu  Ser Ile Gln Asn Gly  Phe Thr Ala 
        995                 1000                 1005             


Thr Asn  Ser Ala Leu Ala Lys  Ile Gln Ser Val Val  Asn Ala Asn 
    1010                 1015                 1020             


Ala Gln  Ala Leu Asn Ser Leu  Leu Gln Gln Leu Phe  Asn Lys Phe 
    1025                 1030                 1035             


Gly Ala  Ile Ser Ser Ser Leu  Gln Glu Ile Leu Ser  Arg Leu Asp 
    1040                 1045                 1050             


Pro Pro  Glu Ala Gln Val Gln  Ile Asp Arg Leu Ile  Asn Gly Arg 
    1055                 1060                 1065             


Leu Thr  Ala Leu Asn Ala Tyr  Val Ser Gln Gln Leu  Ser Asp Ile 
    1070                 1075                 1080             


Thr Leu  Ile Lys Ala Gly Ala  Ser Arg Ala Ile Glu  Lys Val Asn 
    1085                 1090                 1095             


Glu Cys  Val Lys Ser Gln Ser  Pro Arg Ile Asn Phe  Cys Gly Asn 
    1100                 1105                 1110             


Gly Asn  His Ile Leu Ser Leu  Val Gln Asn Ala Pro  Tyr Gly Leu 
    1115                 1120                 1125             


Leu Phe  Ile His Phe Ser Tyr  Lys Pro Thr Ser Phe  Lys Thr Val 
    1130                 1135                 1140             


Leu Val  Ser Pro Gly Leu Cys  Leu Ser Gly Asp Arg  Gly Ile Ala 
    1145                 1150                 1155             


Pro Lys  Gln Gly Tyr Phe Ile  Lys Gln Asn Asp Ser  Trp Met Phe 
    1160                 1165                 1170             


Thr Gly  Ser Ser Tyr Tyr Tyr  Pro Glu Pro Ile Ser  Asp Lys Asn 
    1175                 1180                 1185             


Val Val  Phe Met Asn Ser Cys  Ser Val Asn Phe Thr  Lys Ala Pro 
    1190                 1195                 1200             


Phe Ile  Tyr Leu Asn Asn Ser  Ile Ser Glu Leu Ser  Asp Phe Glu 
    1205                 1210                 1215             


Ala Glu  Leu Ser Gln Trp His  Lys Gln Gly Ser Gly  Gly Ser Gly 
    1220                 1225                 1230             


Asp Ile  Ile Lys Leu Leu Asn  Glu Gln Val Asn Lys  Glu Met Gln 
    1235                 1240                 1245             


Ser Ser  Asn Leu Tyr Met Ser  Met Ser Ser Trp Cys  Tyr Thr His 
    1250                 1255                 1260             


Ser Leu  Asp Gly Ala Gly Leu  Phe Leu Phe Asp His  Ala Ala Glu 
    1265                 1270                 1275             


Glu Tyr  Glu His Ala Lys Lys  Leu Ile Ile Phe Leu  Asn Glu Asn 
    1280                 1285                 1290             


Asn Val  Pro Val Gln Leu Thr  Ser Ile Ser Ala Pro  Glu His Lys 
    1295                 1300                 1305             


Phe Glu  Gly Leu Thr Gln Ile  Phe Gln Lys Ala Tyr  Glu His Glu 
    1310                 1315                 1320             


Gln His  Ile Ser Glu Ser Ile  Asn Asn Ile Val Asp  His Ala Ile 
    1325                 1330                 1335             


Lys Ser  Lys Asp His Ala Thr  Phe Asn Phe Leu Gln  Trp Tyr Val 
    1340                 1345                 1350             


Ala Glu  Gln His Glu Glu Glu  Val Leu Phe Lys Asp  Ile Leu Asp 
    1355                 1360                 1365             


Lys Ile  Glu Leu Ile Gly Asn  Glu Asn His Gly Leu  Tyr Leu Ala 
    1370                 1375                 1380             


Asp Gln  Tyr Val Lys Gly Ile  Ala Lys Ser Arg Lys  Ser Gly Ser 
    1385                 1390                 1395             


<210> 270
<211> 1398
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 270
Val Ile Gly Asp Phe Asn Cys Thr Asn Ser Phe Ile Asn Asp Tyr Asn 
1               5                   10                  15      


Lys Thr Ile Pro Arg Ile Ser Glu Asp Val Val Asp Val Ser Leu Gly 
            20                  25                  30          


Leu Gly Thr Tyr Tyr Val Leu Asn Arg Val Tyr Leu Asn Thr Thr Leu 
        35                  40                  45              


Leu Phe Thr Gly Tyr Phe Pro Lys Ser Gly Ala Asn Phe Arg Asp Leu 
    50                  55                  60                  


Ala Leu Lys Gly Ser Ile Tyr Leu Ser Thr Leu Trp Tyr Lys Pro Pro 
65                  70                  75                  80  


Phe Leu Ser Asp Phe Asn Asn Gly Ile Phe Ser Lys Val Lys Asn Thr 
                85                  90                  95      


Lys Leu Tyr Val Asn Asn Thr Leu Tyr Ser Glu Phe Ser Thr Ile Val 
            100                 105                 110         


Ile Gly Ser Val Phe Val Asn Thr Ser Tyr Thr Ile Val Val Gln Pro 
        115                 120                 125             


His Asn Gly Ile Leu Glu Ile Thr Ala Cys Gln Tyr Thr Met Cys Glu 
    130                 135                 140                 


Tyr Pro His Thr Val Cys Lys Ser Lys Gly Ser Ile Arg Asn Glu Ser 
145                 150                 155                 160 


Trp His Ile Asp Ser Ser Glu Pro Leu Cys Leu Phe Lys Lys Asn Phe 
                165                 170                 175     


Thr Tyr Asn Val Ser Ala Asp Trp Leu Tyr Phe His Phe Tyr Gln Glu 
            180                 185                 190         


Arg Gly Val Phe Tyr Ala Tyr Tyr Ala Asp Val Gly Met Pro Thr Thr 
        195                 200                 205             


Phe Leu Phe Ser Leu Tyr Leu Gly Thr Ile Leu Ser His Tyr Tyr Val 
    210                 215                 220                 


Met Pro Leu Thr Cys Asn Ala Ile Ser Ser Asn Thr Asp Asn Glu Thr 
225                 230                 235                 240 


Leu Glu Tyr Trp Val Thr Pro Leu Ser Arg Arg Gln Tyr Leu Leu Asn 
                245                 250                 255     


Phe Asp Glu His Gly Val Ile Thr Asn Ala Val Asp Cys Ser Ser Ser 
            260                 265                 270         


Phe Leu Ser Glu Ile Gln Cys Lys Thr Gln Ser Phe Ala Pro Asn Thr 
        275                 280                 285             


Gly Val Tyr Asp Leu Ser Gly Phe Thr Val Lys Pro Val Ala Thr Val 
    290                 295                 300                 


Tyr Arg Arg Ile Pro Asn Leu Pro Asp Cys Asp Ile Asp Asn Trp Leu 
305                 310                 315                 320 


Asn Asn Val Ser Val Pro Ser Pro Leu Asn Trp Glu Arg Arg Ile Phe 
                325                 330                 335     


Ser Asn Cys Asn Phe Asn Leu Ser Thr Leu Leu Arg Leu Val His Val 
            340                 345                 350         


Asp Ser Phe Ser Cys Asn Asn Leu Asp Lys Ser Lys Ile Phe Gly Ser 
        355                 360                 365             


Cys Phe Asn Ser Ile Thr Val Asp Lys Phe Ala Ile Pro Asn Arg Arg 
    370                 375                 380                 


Arg Asp Asp Leu Gln Leu Gly Ser Ser Gly Phe Leu Gln Ser Ser Asn 
385                 390                 395                 400 


Tyr Lys Ile Asp Ile Ser Ser Ser Ser Cys Gln Leu Tyr Tyr Ser Leu 
                405                 410                 415     


Pro Leu Val Asn Val Thr Ile Asn Asn Phe Asn Pro Ser Ser Trp Asn 
            420                 425                 430         


Arg Arg Tyr Gly Phe Gly Ser Phe Asn Leu Ser Ser Tyr Asp Val Val 
        435                 440                 445             


Tyr Ser Asp His Cys Phe Ser Val Asn Ser Asp Phe Cys Pro Cys Ala 
    450                 455                 460                 


Asp Pro Ser Val Val Asn Ser Cys Ala Lys Ser Lys Pro Pro Ser Ala 
465                 470                 475                 480 


Ile Cys Pro Ala Gly Thr Lys Tyr Arg His Cys Asp Leu Asp Thr Thr 
                485                 490                 495     


Leu Tyr Val Lys Asn Trp Cys Arg Cys Ser Cys Leu Pro Asp Pro Ile 
            500                 505                 510         


Ser Thr Tyr Ser Pro Asn Thr Cys Pro Gln Lys Lys Val Val Val Gly 
        515                 520                 525             


Ile Gly Glu His Cys Pro Gly Leu Gly Ile Asn Glu Glu Lys Cys Gly 
    530                 535                 540                 


Thr Gln Leu Asn His Ser Ser Cys Phe Cys Ser Pro Asp Ala Phe Leu 
545                 550                 555                 560 


Gly Trp Ser Phe Asp Ser Cys Ile Ser Asn Asn Arg Cys Asn Ile Phe 
                565                 570                 575     


Ser Asn Phe Ile Phe Asn Gly Ile Asn Ser Gly Thr Thr Cys Ser Asn 
            580                 585                 590         


Asp Leu Leu Tyr Ser Asn Thr Glu Ile Ser Thr Gly Val Cys Val Asn 
        595                 600                 605             


Tyr Asp Leu Tyr Gly Ile Thr Gly Gln Gly Ile Phe Lys Glu Val Ser 
    610                 615                 620                 


Ala Ala Tyr Tyr Asn Asn Trp Gln Asn Leu Leu Tyr Asp Ser Asn Gly 
625                 630                 635                 640 


Asn Ile Ile Gly Phe Lys Asp Phe Leu Thr Asn Lys Thr Tyr Thr Ile 
                645                 650                 655     


Leu Pro Cys Tyr Ser Gly Arg Val Ser Ala Ala Phe Tyr Gln Asn Ser 
            660                 665                 670         


Ser Ser Pro Ala Leu Leu Tyr Arg Asn Leu Lys Cys Ser Tyr Val Leu 
        675                 680                 685             


Asn Asn Ile Ser Phe Ile Ser Gln Pro Phe Tyr Phe Asp Ser Tyr Leu 
    690                 695                 700                 


Gly Cys Val Leu Asn Ala Val Asn Leu Thr Ser Tyr Ser Val Ser Ser 
705                 710                 715                 720 


Cys Asp Leu Arg Met Gly Ser Gly Phe Cys Ile Asp Tyr Ala Leu Pro 
                725                 730                 735     


Ser Ser Gly Gly Ser Gly Ser Gly Ile Ser Ser Pro Tyr Arg Phe Val 
            740                 745                 750         


Thr Phe Glu Pro Phe Asn Val Ser Phe Val Asn Asp Ser Val Glu Thr 
        755                 760                 765             


Val Gly Gly Leu Phe Glu Ile Gln Ile Pro Thr Asn Phe Thr Ile Ala 
    770                 775                 780                 


Gly His Glu Glu Phe Ile Gln Thr Ser Ser Pro Lys Val Thr Ile Asp 
785                 790                 795                 800 


Cys Ser Ala Phe Val Cys Ser Asn Tyr Ala Ala Cys His Asp Leu Leu 
                805                 810                 815     


Ser Glu Tyr Gly Thr Phe Cys Asp Asn Ile Asn Ser Ile Leu Asn Glu 
            820                 825                 830         


Val Asn Asp Leu Leu Asp Ile Thr Gln Leu Gln Val Ala Asn Ala Leu 
        835                 840                 845             


Met Gln Gly Val Thr Leu Ser Ser Asn Leu Asn Thr Asn Leu His Ser 
    850                 855                 860                 


Asp Val Asp Asn Ile Asp Phe Lys Ser Leu Leu Gly Cys Leu Gly Ser 
865                 870                 875                 880 


Gln Cys Gly Ser Ser Ser Arg Ser Leu Leu Glu Asp Leu Leu Phe Asn 
                885                 890                 895     


Lys Val Lys Leu Ser Asp Val Gly Phe Val Glu Ala Tyr Asn Asn Cys 
            900                 905                 910         


Thr Gly Gly Ser Glu Ile Arg Asp Leu Leu Cys Val Gln Ser Phe Asn 
        915                 920                 925             


Gly Ile Lys Val Leu Pro Pro Ile Leu Ser Glu Thr Gln Ile Ser Gly 
    930                 935                 940                 


Tyr Thr Thr Ala Ala Thr Val Ala Ala Met Phe Pro Pro Trp Ser Ala 
945                 950                 955                 960 


Ala Ala Gly Val Pro Phe Ser Leu Asn Val Gln Tyr Arg Ile Asn Gly 
                965                 970                 975     


Leu Gly Val Thr Met Asp Val Leu Asn Lys Asn Gln Lys Leu Ile Ala 
            980                 985                 990         


Asn Ala Phe Asn Lys Ala Leu Leu  Ser Ile Gln Asn Gly  Phe Thr Ala 
        995                 1000                 1005             


Thr Asn  Ser Ala Leu Ala Lys  Ile Gln Ser Val Val  Asn Ala Asn 
    1010                 1015                 1020             


Ala Gln  Ala Leu Asn Ser Leu  Leu Gln Gln Leu Phe  Asn Lys Phe 
    1025                 1030                 1035             


Gly Ala  Ile Ser Ser Ser Leu  Gln Glu Ile Leu Ser  Arg Leu Asp 
    1040                 1045                 1050             


Pro Pro  Glu Ala Gln Val Gln  Ile Asp Arg Leu Ile  Asn Gly Arg 
    1055                 1060                 1065             


Leu Thr  Ala Leu Asn Ala Tyr  Val Ser Gln Gln Leu  Ser Asp Ile 
    1070                 1075                 1080             


Thr Leu  Ile Lys Ala Gly Ala  Ser Arg Ala Ile Glu  Lys Val Asn 
    1085                 1090                 1095             


Glu Cys  Val Lys Ser Gln Ser  Pro Arg Ile Asn Phe  Cys Gly Asn 
    1100                 1105                 1110             


Gly Asn  His Ile Leu Ser Leu  Val Gln Asn Ala Pro  Tyr Gly Leu 
    1115                 1120                 1125             


Leu Phe  Ile His Phe Ser Tyr  Lys Pro Thr Ser Phe  Lys Thr Val 
    1130                 1135                 1140             


Leu Val  Ser Pro Gly Leu Cys  Leu Ser Gly Asp Arg  Gly Ile Ala 
    1145                 1150                 1155             


Pro Lys  Gln Gly Tyr Phe Ile  Lys Gln Asn Asp Ser  Trp Met Phe 
    1160                 1165                 1170             


Thr Gly  Ser Ser Tyr Tyr Tyr  Pro Glu Pro Ile Ser  Asp Lys Asn 
    1175                 1180                 1185             


Val Val  Phe Met Asn Ser Cys  Ser Val Asn Phe Thr  Lys Ala Pro 
    1190                 1195                 1200             


Phe Ile  Tyr Leu Asn Asn Leu  Gln Ser Asn Leu Gln  Asp Ile Glu 
    1205                 1210                 1215             


Ala Glu  Leu Ser Gln Ile His  Lys Asn Gly Ser Gly  Gly Ser Gly 
    1220                 1225                 1230             


Asp Ile  Ile Lys Leu Leu Asn  Glu Gln Val Asn Lys  Glu Met Gln 
    1235                 1240                 1245             


Ser Ser  Asn Leu Tyr Met Ser  Met Ser Ser Trp Cys  Tyr Thr His 
    1250                 1255                 1260             


Ser Leu  Asp Gly Ala Gly Leu  Phe Leu Phe Asp His  Ala Ala Glu 
    1265                 1270                 1275             


Glu Tyr  Glu His Ala Lys Lys  Leu Ile Ile Phe Leu  Asn Glu Asn 
    1280                 1285                 1290             


Asn Val  Pro Val Gln Leu Thr  Ser Ile Ser Ala Pro  Glu His Lys 
    1295                 1300                 1305             


Phe Glu  Gly Leu Thr Gln Ile  Phe Gln Lys Ala Tyr  Glu His Glu 
    1310                 1315                 1320             


Gln His  Ile Ser Glu Ser Ile  Asn Asn Ile Val Asp  His Ala Ile 
    1325                 1330                 1335             


Lys Ser  Lys Asp His Ala Thr  Phe Asn Phe Leu Gln  Trp Tyr Val 
    1340                 1345                 1350             


Ala Glu  Gln His Glu Glu Glu  Val Leu Phe Lys Asp  Ile Leu Asp 
    1355                 1360                 1365             


Lys Ile  Glu Leu Ile Gly Asn  Glu Asn His Gly Leu  Tyr Leu Ala 
    1370                 1375                 1380             


Asp Gln  Tyr Val Lys Gly Ile  Ala Lys Ser Arg Lys  Ser Gly Ser 
    1385                 1390                 1395             


<210> 271
<211> 1398
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 271
Val Ile Gly Asp Phe Asn Cys Thr Asn Ser Phe Ile Asn Asp Tyr Asn 
1               5                   10                  15      


Lys Thr Ile Pro Arg Ile Ser Glu Asp Val Val Asp Val Ser Leu Gly 
            20                  25                  30          


Leu Gly Thr Tyr Tyr Val Leu Asn Arg Val Tyr Leu Asn Thr Thr Leu 
        35                  40                  45              


Leu Phe Thr Gly Tyr Phe Pro Lys Ser Gly Ala Asn Phe Arg Asp Leu 
    50                  55                  60                  


Ala Leu Lys Gly Ser Ile Tyr Leu Ser Thr Leu Trp Tyr Lys Pro Pro 
65                  70                  75                  80  


Phe Leu Ser Asp Phe Asn Asn Gly Ile Phe Ser Lys Val Lys Asn Thr 
                85                  90                  95      


Lys Leu Tyr Val Asn Asn Thr Leu Tyr Ser Glu Phe Ser Thr Ile Val 
            100                 105                 110         


Ile Gly Ser Val Phe Val Asn Thr Ser Tyr Thr Ile Val Val Gln Pro 
        115                 120                 125             


His Asn Gly Ile Leu Glu Ile Thr Ala Cys Gln Tyr Thr Met Cys Glu 
    130                 135                 140                 


Tyr Pro His Thr Val Cys Lys Ser Lys Gly Ser Ile Arg Asn Glu Ser 
145                 150                 155                 160 


Trp His Ile Asp Ser Ser Glu Pro Leu Cys Leu Phe Lys Lys Asn Phe 
                165                 170                 175     


Thr Tyr Asn Val Ser Ala Asp Trp Leu Tyr Phe His Phe Tyr Gln Glu 
            180                 185                 190         


Arg Gly Val Phe Tyr Ala Tyr Tyr Ala Asp Val Gly Met Pro Thr Thr 
        195                 200                 205             


Phe Leu Phe Ser Leu Tyr Leu Gly Thr Ile Leu Ser His Tyr Tyr Val 
    210                 215                 220                 


Met Pro Leu Thr Cys Asn Ala Ile Ser Ser Asn Thr Asp Asn Glu Thr 
225                 230                 235                 240 


Leu Glu Tyr Trp Val Thr Pro Leu Ser Arg Arg Gln Tyr Leu Leu Asn 
                245                 250                 255     


Phe Asp Glu His Gly Val Ile Thr Asn Ala Val Asp Cys Ser Ser Ser 
            260                 265                 270         


Phe Leu Ser Glu Ile Gln Cys Lys Thr Gln Ser Phe Ala Pro Asn Thr 
        275                 280                 285             


Gly Val Tyr Asp Leu Ser Gly Phe Thr Val Lys Pro Val Ala Thr Val 
    290                 295                 300                 


Tyr Arg Arg Ile Pro Asn Leu Pro Asp Cys Asp Ile Asp Asn Trp Leu 
305                 310                 315                 320 


Asn Asn Val Ser Val Pro Ser Pro Leu Asn Trp Glu Arg Arg Ile Phe 
                325                 330                 335     


Ser Asn Cys Asn Phe Asn Leu Ser Thr Leu Leu Arg Leu Val His Val 
            340                 345                 350         


Asp Ser Phe Ser Cys Asn Asn Leu Asp Lys Ser Lys Ile Phe Gly Ser 
        355                 360                 365             


Cys Phe Asn Ser Ile Thr Val Asp Lys Phe Ala Ile Pro Asn Arg Arg 
    370                 375                 380                 


Arg Asp Asp Leu Gln Leu Gly Ser Ser Gly Phe Leu Gln Ser Ser Asn 
385                 390                 395                 400 


Tyr Lys Ile Asp Ile Ser Ser Ser Ser Cys Gln Leu Tyr Tyr Ser Leu 
                405                 410                 415     


Pro Leu Val Asn Val Thr Ile Asn Asn Phe Asn Pro Ser Ser Trp Asn 
            420                 425                 430         


Arg Arg Tyr Gly Phe Gly Ser Phe Asn Leu Ser Ser Tyr Asp Val Val 
        435                 440                 445             


Tyr Ser Asp His Cys Phe Ser Val Asn Ser Asp Phe Cys Pro Cys Ala 
    450                 455                 460                 


Asp Pro Ser Val Val Asn Ser Cys Ala Lys Ser Lys Pro Pro Ser Ala 
465                 470                 475                 480 


Ile Cys Pro Ala Gly Thr Lys Tyr Arg His Cys Asp Leu Asp Thr Thr 
                485                 490                 495     


Leu Tyr Val Lys Asn Trp Cys Arg Cys Ser Cys Leu Pro Asp Pro Ile 
            500                 505                 510         


Ser Thr Tyr Ser Pro Asn Thr Cys Pro Gln Lys Lys Val Val Val Gly 
        515                 520                 525             


Ile Gly Glu His Cys Pro Gly Leu Gly Ile Asn Glu Glu Lys Cys Gly 
    530                 535                 540                 


Thr Gln Leu Asn His Ser Ser Cys Phe Cys Ser Pro Asp Ala Phe Leu 
545                 550                 555                 560 


Gly Trp Ser Phe Asp Ser Cys Ile Ser Asn Asn Arg Cys Asn Ile Phe 
                565                 570                 575     


Ser Asn Phe Ile Phe Asn Gly Ile Asn Ser Gly Thr Thr Cys Ser Asn 
            580                 585                 590         


Asp Leu Leu Tyr Ser Asn Thr Glu Ile Ser Thr Gly Val Cys Val Asn 
        595                 600                 605             


Tyr Asp Leu Tyr Gly Ile Thr Gly Gln Gly Ile Phe Lys Glu Val Ser 
    610                 615                 620                 


Ala Ala Tyr Tyr Asn Asn Trp Gln Asn Leu Leu Tyr Asp Ser Asn Gly 
625                 630                 635                 640 


Asn Ile Ile Gly Phe Lys Asp Phe Leu Thr Asn Lys Thr Tyr Thr Ile 
                645                 650                 655     


Leu Pro Cys Tyr Ser Gly Arg Val Ser Ala Ala Phe Tyr Gln Asn Ser 
            660                 665                 670         


Ser Ser Pro Ala Leu Leu Tyr Arg Asn Leu Lys Cys Ser Tyr Val Leu 
        675                 680                 685             


Asn Asn Ile Ser Phe Ile Ser Gln Pro Phe Tyr Phe Asp Ser Tyr Leu 
    690                 695                 700                 


Gly Cys Val Leu Asn Ala Val Asn Leu Thr Ser Tyr Ser Val Ser Ser 
705                 710                 715                 720 


Cys Asp Leu Arg Met Gly Ser Gly Phe Cys Ile Asp Tyr Ala Leu Pro 
                725                 730                 735     


Ser Ser Gly Gly Ser Gly Ser Gly Ile Ser Ser Pro Tyr Arg Phe Val 
            740                 745                 750         


Thr Phe Glu Pro Phe Asn Val Ser Phe Val Asn Asp Ser Val Glu Thr 
        755                 760                 765             


Val Gly Gly Leu Phe Glu Ile Gln Ile Pro Thr Asn Phe Thr Ile Ala 
    770                 775                 780                 


Gly His Glu Glu Phe Ile Gln Thr Ser Ser Pro Lys Val Thr Ile Asp 
785                 790                 795                 800 


Cys Ser Ala Phe Val Cys Ser Asn Tyr Ala Ala Cys His Asp Leu Leu 
                805                 810                 815     


Ser Glu Tyr Gly Thr Phe Cys Asp Asn Ile Asn Ser Ile Leu Asn Glu 
            820                 825                 830         


Val Asn Asp Leu Leu Asp Ile Thr Gln Leu Gln Val Ala Asn Ala Leu 
        835                 840                 845             


Met Gln Gly Val Thr Leu Ser Ser Asn Leu Asn Thr Asn Leu His Ser 
    850                 855                 860                 


Asp Val Asp Asn Ile Asp Phe Lys Ser Leu Leu Gly Cys Leu Gly Ser 
865                 870                 875                 880 


Gln Cys Gly Ser Ser Ser Arg Ser Leu Leu Glu Asp Leu Leu Phe Asn 
                885                 890                 895     


Lys Val Lys Leu Ser Asp Val Gly Phe Val Glu Ala Tyr Asn Asn Cys 
            900                 905                 910         


Thr Gly Gly Ser Glu Ile Arg Asp Leu Leu Cys Val Gln Ser Phe Asn 
        915                 920                 925             


Gly Ile Lys Val Leu Pro Pro Ile Leu Ser Glu Thr Gln Ile Ser Gly 
    930                 935                 940                 


Tyr Thr Thr Ala Ala Thr Val Ala Ala Met Phe Pro Pro Trp Ser Ala 
945                 950                 955                 960 


Ala Ala Gly Val Pro Phe Ser Leu Asn Val Gln Tyr Arg Ile Asn Gly 
                965                 970                 975     


Leu Gly Val Thr Met Asp Val Leu Asn Lys Asn Gln Lys Leu Ile Ala 
            980                 985                 990         


Asn Ala Phe Asn Lys Ala Leu Leu  Ser Ile Gln Asn Gly  Phe Thr Ala 
        995                 1000                 1005             


Thr Asn  Ser Ala Leu Ala Lys  Ile Gln Ser Val Val  Asn Ala Asn 
    1010                 1015                 1020             


Ala Gln  Ala Leu Asn Ser Leu  Leu Gln Gln Leu Phe  Asn Lys Phe 
    1025                 1030                 1035             


Gly Ala  Ile Ser Ser Ser Leu  Gln Glu Ile Leu Ser  Arg Leu Asp 
    1040                 1045                 1050             


Pro Pro  Glu Ala Gln Val Gln  Ile Asp Arg Leu Ile  Asn Gly Arg 
    1055                 1060                 1065             


Leu Thr  Ala Leu Asn Ala Tyr  Val Ser Gln Gln Leu  Ser Asp Ile 
    1070                 1075                 1080             


Thr Leu  Ile Lys Ala Gly Ala  Ser Arg Ala Ile Glu  Lys Val Asn 
    1085                 1090                 1095             


Glu Cys  Val Lys Ser Gln Ser  Pro Arg Ile Asn Phe  Cys Gly Asn 
    1100                 1105                 1110             


Gly Asn  His Ile Leu Ser Leu  Val Gln Asn Ala Pro  Tyr Gly Leu 
    1115                 1120                 1125             


Leu Phe  Ile His Phe Ser Tyr  Lys Pro Thr Ser Phe  Lys Thr Val 
    1130                 1135                 1140             


Leu Val  Ser Pro Gly Leu Cys  Leu Ser Gly Asp Arg  Gly Ile Ala 
    1145                 1150                 1155             


Pro Lys  Gln Gly Tyr Phe Ile  Lys Gln Asn Asp Ser  Trp Met Phe 
    1160                 1165                 1170             


Thr Gly  Ser Ser Tyr Tyr Tyr  Pro Glu Pro Ile Ser  Asp Lys Asn 
    1175                 1180                 1185             


Val Val  Phe Met Asn Ser Cys  Ser Val Asn Phe Thr  Lys Ala Pro 
    1190                 1195                 1200             


Phe Ile  Tyr Leu Asn Asn Leu  Gln Ser Asn Leu Gln  Asp Ile Glu 
    1205                 1210                 1215             


Ala Glu  Leu Ser Gln Ile His  Lys Gln Gly Ser Gly  Gly Ser Gly 
    1220                 1225                 1230             


Asp Ile  Ile Lys Leu Leu Asn  Glu Gln Val Asn Lys  Glu Met Gln 
    1235                 1240                 1245             


Ser Ser  Asn Leu Tyr Met Ser  Met Ser Ser Trp Cys  Tyr Thr His 
    1250                 1255                 1260             


Ser Leu  Asp Gly Ala Gly Leu  Phe Leu Phe Asp His  Ala Ala Glu 
    1265                 1270                 1275             


Glu Tyr  Glu His Ala Lys Lys  Leu Ile Ile Phe Leu  Asn Glu Asn 
    1280                 1285                 1290             


Asn Val  Pro Val Gln Leu Thr  Ser Ile Ser Ala Pro  Glu His Lys 
    1295                 1300                 1305             


Phe Glu  Gly Leu Thr Gln Ile  Phe Gln Lys Ala Tyr  Glu His Glu 
    1310                 1315                 1320             


Gln His  Ile Ser Glu Ser Ile  Asn Asn Ile Val Asp  His Ala Ile 
    1325                 1330                 1335             


Lys Ser  Lys Asp His Ala Thr  Phe Asn Phe Leu Gln  Trp Tyr Val 
    1340                 1345                 1350             


Ala Glu  Gln His Glu Glu Glu  Val Leu Phe Lys Asp  Ile Leu Asp 
    1355                 1360                 1365             


Lys Ile  Glu Leu Ile Gly Asn  Glu Asn His Gly Leu  Tyr Leu Ala 
    1370                 1375                 1380             


Asp Gln  Tyr Val Lys Gly Ile  Ala Lys Ser Arg Lys  Ser Gly Ser 
    1385                 1390                 1395             


<210> 272
<211> 1398
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 272
Val Ile Gly Asp Phe Asn Cys Thr Asn Ser Phe Ile Asn Asp Tyr Asn 
1               5                   10                  15      


Lys Thr Ile Pro Arg Ile Ser Glu Asp Val Val Asp Val Ser Leu Gly 
            20                  25                  30          


Leu Gly Thr Tyr Tyr Val Leu Asn Arg Val Tyr Leu Asn Thr Thr Leu 
        35                  40                  45              


Leu Phe Thr Gly Tyr Phe Pro Lys Ser Gly Ala Asn Phe Arg Asp Leu 
    50                  55                  60                  


Ala Leu Lys Gly Ser Ile Tyr Leu Ser Thr Leu Trp Tyr Lys Pro Pro 
65                  70                  75                  80  


Phe Leu Ser Asp Phe Asn Asn Gly Ile Phe Ser Lys Val Lys Asn Thr 
                85                  90                  95      


Lys Leu Tyr Val Asn Asn Thr Leu Tyr Ser Glu Phe Ser Thr Ile Val 
            100                 105                 110         


Ile Gly Ser Val Phe Val Asn Thr Ser Tyr Thr Ile Val Val Gln Pro 
        115                 120                 125             


His Asn Gly Ile Leu Glu Ile Thr Ala Cys Gln Tyr Thr Met Cys Glu 
    130                 135                 140                 


Tyr Pro His Thr Val Cys Lys Ser Lys Gly Ser Ile Arg Asn Glu Ser 
145                 150                 155                 160 


Trp His Ile Asp Ser Ser Glu Pro Leu Cys Leu Phe Lys Lys Asn Phe 
                165                 170                 175     


Thr Tyr Asn Val Ser Ala Asp Trp Leu Tyr Phe His Phe Tyr Gln Glu 
            180                 185                 190         


Arg Gly Val Phe Tyr Ala Tyr Tyr Ala Asp Val Gly Met Pro Thr Thr 
        195                 200                 205             


Phe Leu Phe Ser Leu Tyr Leu Gly Thr Ile Leu Ser His Tyr Tyr Val 
    210                 215                 220                 


Met Pro Leu Thr Cys Asn Ala Ile Ser Ser Asn Thr Asp Asn Glu Thr 
225                 230                 235                 240 


Leu Glu Tyr Trp Val Thr Pro Leu Ser Arg Arg Gln Tyr Leu Leu Asn 
                245                 250                 255     


Phe Asp Glu His Gly Val Ile Thr Asn Ala Val Asp Cys Ser Ser Ser 
            260                 265                 270         


Phe Leu Ser Glu Ile Gln Cys Lys Thr Gln Ser Phe Ala Pro Asn Thr 
        275                 280                 285             


Gly Val Tyr Asp Leu Ser Gly Phe Thr Val Lys Pro Val Ala Thr Val 
    290                 295                 300                 


Tyr Arg Arg Ile Pro Asn Leu Pro Asp Cys Asp Ile Asp Asn Trp Leu 
305                 310                 315                 320 


Asn Asn Val Ser Val Pro Ser Pro Leu Asn Trp Glu Arg Arg Ile Phe 
                325                 330                 335     


Ser Asn Cys Asn Phe Asn Leu Ser Thr Leu Leu Arg Leu Val His Val 
            340                 345                 350         


Asp Ser Phe Ser Cys Asn Asn Leu Asp Lys Ser Lys Ile Phe Gly Ser 
        355                 360                 365             


Cys Phe Asn Ser Ile Thr Val Asp Lys Phe Ala Ile Pro Asn Arg Arg 
    370                 375                 380                 


Arg Asp Asp Leu Gln Leu Gly Ser Ser Gly Phe Leu Gln Ser Ser Asn 
385                 390                 395                 400 


Tyr Lys Ile Asp Ile Ser Ser Ser Ser Cys Gln Leu Tyr Tyr Ser Leu 
                405                 410                 415     


Pro Leu Val Asn Val Thr Ile Asn Asn Phe Asn Pro Ser Ser Trp Asn 
            420                 425                 430         


Arg Arg Tyr Gly Phe Gly Ser Phe Asn Leu Ser Ser Tyr Asp Val Val 
        435                 440                 445             


Tyr Ser Asp His Cys Phe Ser Val Asn Ser Asp Phe Cys Pro Cys Ala 
    450                 455                 460                 


Asp Pro Ser Val Val Asn Ser Cys Ala Lys Ser Lys Pro Pro Ser Ala 
465                 470                 475                 480 


Ile Cys Pro Ala Gly Thr Lys Tyr Arg His Cys Asp Leu Asp Thr Thr 
                485                 490                 495     


Leu Tyr Val Lys Asn Trp Cys Arg Cys Ser Cys Leu Pro Asp Pro Ile 
            500                 505                 510         


Ser Thr Tyr Ser Pro Asn Thr Cys Pro Gln Lys Lys Val Val Val Gly 
        515                 520                 525             


Ile Gly Glu His Cys Pro Gly Leu Gly Ile Asn Glu Glu Lys Cys Gly 
    530                 535                 540                 


Thr Gln Leu Asn His Ser Ser Cys Phe Cys Ser Pro Asp Ala Phe Leu 
545                 550                 555                 560 


Gly Trp Ser Phe Asp Ser Cys Ile Ser Asn Asn Arg Cys Asn Ile Phe 
                565                 570                 575     


Ser Asn Phe Ile Phe Asn Gly Ile Asn Ser Gly Thr Thr Cys Ser Asn 
            580                 585                 590         


Asp Leu Leu Tyr Ser Asn Thr Glu Ile Ser Thr Gly Val Cys Val Asn 
        595                 600                 605             


Tyr Asp Leu Tyr Gly Ile Thr Gly Gln Gly Ile Phe Lys Glu Val Ser 
    610                 615                 620                 


Ala Ala Tyr Tyr Asn Asn Trp Gln Asn Leu Leu Tyr Asp Ser Asn Gly 
625                 630                 635                 640 


Asn Ile Ile Gly Phe Lys Asp Phe Leu Thr Asn Lys Thr Tyr Thr Ile 
                645                 650                 655     


Leu Pro Cys Tyr Ser Gly Arg Val Ser Ala Ala Phe Tyr Gln Asn Ser 
            660                 665                 670         


Ser Ser Pro Ala Leu Leu Tyr Arg Asn Leu Lys Cys Ser Tyr Val Leu 
        675                 680                 685             


Asn Asn Ile Ser Phe Ile Ser Gln Pro Phe Tyr Phe Asp Ser Tyr Leu 
    690                 695                 700                 


Gly Cys Val Leu Asn Ala Val Asn Leu Thr Ser Tyr Ser Val Ser Ser 
705                 710                 715                 720 


Cys Asp Leu Arg Met Gly Ser Gly Phe Cys Ile Asp Tyr Ala Leu Pro 
                725                 730                 735     


Ser Ser Gly Gly Ser Gly Ser Gly Ile Ser Ser Pro Tyr Arg Phe Val 
            740                 745                 750         


Thr Phe Glu Pro Phe Asn Val Ser Phe Val Asn Asp Ser Val Glu Thr 
        755                 760                 765             


Val Gly Gly Leu Phe Glu Ile Gln Ile Pro Thr Asn Phe Thr Ile Ala 
    770                 775                 780                 


Gly His Glu Glu Phe Ile Gln Thr Ser Ser Pro Lys Val Thr Ile Asp 
785                 790                 795                 800 


Cys Ser Ala Phe Val Cys Ser Asn Tyr Ala Ala Cys His Asp Leu Leu 
                805                 810                 815     


Ser Glu Tyr Gly Thr Phe Cys Asp Asn Ile Asn Ser Ile Leu Asn Glu 
            820                 825                 830         


Val Asn Asp Leu Leu Asp Ile Thr Gln Leu Gln Val Ala Asn Ala Leu 
        835                 840                 845             


Met Gln Gly Val Thr Leu Ser Ser Asn Leu Asn Thr Asn Leu His Ser 
    850                 855                 860                 


Asp Val Asp Asn Ile Asp Phe Lys Ser Leu Leu Gly Cys Leu Gly Ser 
865                 870                 875                 880 


Gln Cys Gly Ser Ser Ser Arg Ser Leu Leu Glu Asp Leu Leu Phe Asn 
                885                 890                 895     


Lys Val Lys Leu Ser Asp Val Gly Phe Val Glu Ala Tyr Asn Asn Cys 
            900                 905                 910         


Thr Gly Gly Ser Glu Ile Arg Asp Leu Leu Cys Val Gln Ser Phe Asn 
        915                 920                 925             


Gly Ile Lys Val Leu Pro Pro Ile Leu Ser Glu Thr Gln Ile Ser Gly 
    930                 935                 940                 


Tyr Thr Thr Ala Ala Thr Val Ala Ala Met Phe Pro Pro Trp Ser Ala 
945                 950                 955                 960 


Ala Ala Gly Val Pro Phe Ser Leu Asn Val Gln Tyr Arg Ile Asn Gly 
                965                 970                 975     


Leu Gly Val Thr Met Asp Val Leu Asn Lys Asn Gln Lys Leu Ile Ala 
            980                 985                 990         


Asn Ala Phe Asn Lys Ala Leu Leu  Ser Ile Gln Asn Gly  Phe Thr Ala 
        995                 1000                 1005             


Thr Asn  Ser Ala Leu Ala Lys  Ile Gln Ser Val Val  Asn Ala Asn 
    1010                 1015                 1020             


Ala Gln  Ala Leu Asn Ser Leu  Leu Gln Gln Leu Phe  Asn Lys Phe 
    1025                 1030                 1035             


Gly Ala  Ile Ser Ser Ser Leu  Gln Glu Ile Leu Ser  Arg Leu Asp 
    1040                 1045                 1050             


Pro Pro  Glu Ala Gln Val Gln  Ile Asp Arg Leu Ile  Asn Gly Arg 
    1055                 1060                 1065             


Leu Thr  Ala Leu Asn Ala Tyr  Val Ser Gln Gln Leu  Ser Asp Ile 
    1070                 1075                 1080             


Thr Leu  Ile Lys Ala Gly Ala  Ser Arg Ala Ile Glu  Lys Val Asn 
    1085                 1090                 1095             


Glu Cys  Val Lys Ser Gln Ser  Pro Arg Ile Asn Phe  Cys Gly Asn 
    1100                 1105                 1110             


Gly Asn  His Ile Leu Ser Leu  Val Gln Asn Ala Pro  Tyr Gly Leu 
    1115                 1120                 1125             


Leu Phe  Ile His Phe Ser Tyr  Lys Pro Thr Ser Phe  Lys Thr Val 
    1130                 1135                 1140             


Leu Val  Ser Pro Gly Leu Cys  Leu Ser Gly Asp Arg  Gly Ile Ala 
    1145                 1150                 1155             


Pro Lys  Gln Gly Tyr Phe Ile  Lys Gln Asn Asp Ser  Trp Met Phe 
    1160                 1165                 1170             


Thr Gly  Ser Ser Tyr Tyr Tyr  Pro Glu Pro Ile Ser  Asp Lys Asn 
    1175                 1180                 1185             


Val Val  Phe Met Asn Ser Cys  Ser Val Asn Phe Thr  Lys Ala Pro 
    1190                 1195                 1200             


Phe Ile  Tyr Leu Asn Asn Leu  Gln Ser Asn Leu Gln  Asp Leu Glu 
    1205                 1210                 1215             


Ala Glu  Leu Ser Gln Leu His  Lys Asn Gly Ser Gly  Gly Ser Gly 
    1220                 1225                 1230             


Asp Ile  Ile Lys Leu Leu Asn  Glu Gln Val Asn Lys  Glu Met Gln 
    1235                 1240                 1245             


Ser Ser  Asn Leu Tyr Met Ser  Met Ser Ser Trp Cys  Tyr Thr His 
    1250                 1255                 1260             


Ser Leu  Asp Gly Ala Gly Leu  Phe Leu Phe Asp His  Ala Ala Glu 
    1265                 1270                 1275             


Glu Tyr  Glu His Ala Lys Lys  Leu Ile Ile Phe Leu  Asn Glu Asn 
    1280                 1285                 1290             


Asn Val  Pro Val Gln Leu Thr  Ser Ile Ser Ala Pro  Glu His Lys 
    1295                 1300                 1305             


Phe Glu  Gly Leu Thr Gln Ile  Phe Gln Lys Ala Tyr  Glu His Glu 
    1310                 1315                 1320             


Gln His  Ile Ser Glu Ser Ile  Asn Asn Ile Val Asp  His Ala Ile 
    1325                 1330                 1335             


Lys Ser  Lys Asp His Ala Thr  Phe Asn Phe Leu Gln  Trp Tyr Val 
    1340                 1345                 1350             


Ala Glu  Gln His Glu Glu Glu  Val Leu Phe Lys Asp  Ile Leu Asp 
    1355                 1360                 1365             


Lys Ile  Glu Leu Ile Gly Asn  Glu Asn His Gly Leu  Tyr Leu Ala 
    1370                 1375                 1380             


Asp Gln  Tyr Val Lys Gly Ile  Ala Lys Ser Arg Lys  Ser Gly Ser 
    1385                 1390                 1395             


<210> 273
<211> 1398
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 273
Val Ile Gly Asp Phe Asn Cys Thr Asn Ser Phe Ile Asn Asp Tyr Asn 
1               5                   10                  15      


Lys Thr Ile Pro Arg Ile Ser Glu Asp Val Val Asp Val Ser Leu Gly 
            20                  25                  30          


Leu Gly Thr Tyr Tyr Val Leu Asn Arg Val Tyr Leu Asn Thr Thr Leu 
        35                  40                  45              


Leu Phe Thr Gly Tyr Phe Pro Lys Ser Gly Ala Asn Phe Arg Asp Leu 
    50                  55                  60                  


Ala Leu Lys Gly Ser Ile Tyr Leu Ser Thr Leu Trp Tyr Lys Pro Pro 
65                  70                  75                  80  


Phe Leu Ser Asp Phe Asn Asn Gly Ile Phe Ser Lys Val Lys Asn Thr 
                85                  90                  95      


Lys Leu Tyr Val Asn Asn Thr Leu Tyr Ser Glu Phe Ser Thr Ile Val 
            100                 105                 110         


Ile Gly Ser Val Phe Val Asn Thr Ser Tyr Thr Ile Val Val Gln Pro 
        115                 120                 125             


His Asn Gly Ile Leu Glu Ile Thr Ala Cys Gln Tyr Thr Met Cys Glu 
    130                 135                 140                 


Tyr Pro His Thr Val Cys Lys Ser Lys Gly Ser Ile Arg Asn Glu Ser 
145                 150                 155                 160 


Trp His Ile Asp Ser Ser Glu Pro Leu Cys Leu Phe Lys Lys Asn Phe 
                165                 170                 175     


Thr Tyr Asn Val Ser Ala Asp Trp Leu Tyr Phe His Phe Tyr Gln Glu 
            180                 185                 190         


Arg Gly Val Phe Tyr Ala Tyr Tyr Ala Asp Val Gly Met Pro Thr Thr 
        195                 200                 205             


Phe Leu Phe Ser Leu Tyr Leu Gly Thr Ile Leu Ser His Tyr Tyr Val 
    210                 215                 220                 


Met Pro Leu Thr Cys Asn Ala Ile Ser Ser Asn Thr Asp Asn Glu Thr 
225                 230                 235                 240 


Leu Glu Tyr Trp Val Thr Pro Leu Ser Arg Arg Gln Tyr Leu Leu Asn 
                245                 250                 255     


Phe Asp Glu His Gly Val Ile Thr Asn Ala Val Asp Cys Ser Ser Ser 
            260                 265                 270         


Phe Leu Ser Glu Ile Gln Cys Lys Thr Gln Ser Phe Ala Pro Asn Thr 
        275                 280                 285             


Gly Val Tyr Asp Leu Ser Gly Phe Thr Val Lys Pro Val Ala Thr Val 
    290                 295                 300                 


Tyr Arg Arg Ile Pro Asn Leu Pro Asp Cys Asp Ile Asp Asn Trp Leu 
305                 310                 315                 320 


Asn Asn Val Ser Val Pro Ser Pro Leu Asn Trp Glu Arg Arg Ile Phe 
                325                 330                 335     


Ser Asn Cys Asn Phe Asn Leu Ser Thr Leu Leu Arg Leu Val His Val 
            340                 345                 350         


Asp Ser Phe Ser Cys Asn Asn Leu Asp Lys Ser Lys Ile Phe Gly Ser 
        355                 360                 365             


Cys Phe Asn Ser Ile Thr Val Asp Lys Phe Ala Ile Pro Asn Arg Arg 
    370                 375                 380                 


Arg Asp Asp Leu Gln Leu Gly Ser Ser Gly Phe Leu Gln Ser Ser Asn 
385                 390                 395                 400 


Tyr Lys Ile Asp Ile Ser Ser Ser Ser Cys Gln Leu Tyr Tyr Ser Leu 
                405                 410                 415     


Pro Leu Val Asn Val Thr Ile Asn Asn Phe Asn Pro Ser Ser Trp Asn 
            420                 425                 430         


Arg Arg Tyr Gly Phe Gly Ser Phe Asn Leu Ser Ser Tyr Asp Val Val 
        435                 440                 445             


Tyr Ser Asp His Cys Phe Ser Val Asn Ser Asp Phe Cys Pro Cys Ala 
    450                 455                 460                 


Asp Pro Ser Val Val Asn Ser Cys Ala Lys Ser Lys Pro Pro Ser Ala 
465                 470                 475                 480 


Ile Cys Pro Ala Gly Thr Lys Tyr Arg His Cys Asp Leu Asp Thr Thr 
                485                 490                 495     


Leu Tyr Val Lys Asn Trp Cys Arg Cys Ser Cys Leu Pro Asp Pro Ile 
            500                 505                 510         


Ser Thr Tyr Ser Pro Asn Thr Cys Pro Gln Lys Lys Val Val Val Gly 
        515                 520                 525             


Ile Gly Glu His Cys Pro Gly Leu Gly Ile Asn Glu Glu Lys Cys Gly 
    530                 535                 540                 


Thr Gln Leu Asn His Ser Ser Cys Phe Cys Ser Pro Asp Ala Phe Leu 
545                 550                 555                 560 


Gly Trp Ser Phe Asp Ser Cys Ile Ser Asn Asn Arg Cys Asn Ile Phe 
                565                 570                 575     


Ser Asn Phe Ile Phe Asn Gly Ile Asn Ser Gly Thr Thr Cys Ser Asn 
            580                 585                 590         


Asp Leu Leu Tyr Ser Asn Thr Glu Ile Ser Thr Gly Val Cys Val Asn 
        595                 600                 605             


Tyr Asp Leu Tyr Gly Ile Thr Gly Gln Gly Ile Phe Lys Glu Val Ser 
    610                 615                 620                 


Ala Ala Tyr Tyr Asn Asn Trp Gln Asn Leu Leu Tyr Asp Ser Asn Gly 
625                 630                 635                 640 


Asn Ile Ile Gly Phe Lys Asp Phe Leu Thr Asn Lys Thr Tyr Thr Ile 
                645                 650                 655     


Leu Pro Cys Tyr Ser Gly Arg Val Ser Ala Ala Phe Tyr Gln Asn Ser 
            660                 665                 670         


Ser Ser Pro Ala Leu Leu Tyr Arg Asn Leu Lys Cys Ser Tyr Val Leu 
        675                 680                 685             


Asn Asn Ile Ser Phe Ile Ser Gln Pro Phe Tyr Phe Asp Ser Tyr Leu 
    690                 695                 700                 


Gly Cys Val Leu Asn Ala Val Asn Leu Thr Ser Tyr Ser Val Ser Ser 
705                 710                 715                 720 


Cys Asp Leu Arg Met Gly Ser Gly Phe Cys Ile Asp Tyr Ala Leu Pro 
                725                 730                 735     


Ser Ser Gly Gly Ser Gly Ser Gly Ile Ser Ser Pro Tyr Arg Phe Val 
            740                 745                 750         


Thr Phe Glu Pro Phe Asn Val Ser Phe Val Asn Asp Ser Val Glu Thr 
        755                 760                 765             


Val Gly Gly Leu Phe Glu Ile Gln Ile Pro Thr Asn Phe Thr Ile Ala 
    770                 775                 780                 


Gly His Glu Glu Phe Ile Gln Thr Ser Ser Pro Lys Val Thr Ile Asp 
785                 790                 795                 800 


Cys Ser Ala Phe Val Cys Ser Asn Tyr Ala Ala Cys His Asp Leu Leu 
                805                 810                 815     


Ser Glu Tyr Gly Thr Phe Cys Asp Asn Ile Asn Ser Ile Leu Asn Glu 
            820                 825                 830         


Val Asn Asp Leu Leu Asp Ile Thr Gln Leu Gln Val Ala Asn Ala Leu 
        835                 840                 845             


Met Gln Gly Val Thr Leu Ser Ser Asn Leu Asn Thr Asn Leu His Ser 
    850                 855                 860                 


Asp Val Asp Asn Ile Asp Phe Lys Ser Leu Leu Gly Cys Leu Gly Ser 
865                 870                 875                 880 


Gln Cys Gly Ser Ser Ser Arg Ser Leu Leu Glu Asp Leu Leu Phe Asn 
                885                 890                 895     


Lys Val Lys Leu Ser Asp Val Gly Phe Val Glu Ala Tyr Asn Asn Cys 
            900                 905                 910         


Thr Gly Gly Ser Glu Ile Arg Asp Leu Leu Cys Val Gln Ser Phe Asn 
        915                 920                 925             


Gly Ile Lys Val Leu Pro Pro Ile Leu Ser Glu Thr Gln Ile Ser Gly 
    930                 935                 940                 


Tyr Thr Thr Ala Ala Thr Val Ala Ala Met Phe Pro Pro Trp Ser Ala 
945                 950                 955                 960 


Ala Ala Gly Val Pro Phe Ser Leu Asn Val Gln Tyr Arg Ile Asn Gly 
                965                 970                 975     


Leu Gly Val Thr Met Asp Val Leu Asn Lys Asn Gln Lys Leu Ile Ala 
            980                 985                 990         


Asn Ala Phe Asn Lys Ala Leu Leu  Ser Ile Gln Asn Gly  Phe Thr Ala 
        995                 1000                 1005             


Thr Asn  Ser Ala Leu Ala Lys  Ile Gln Ser Val Val  Asn Ala Asn 
    1010                 1015                 1020             


Ala Gln  Ala Leu Asn Ser Leu  Leu Gln Gln Leu Phe  Asn Lys Phe 
    1025                 1030                 1035             


Gly Ala  Ile Ser Ser Ser Leu  Gln Glu Ile Leu Ser  Arg Leu Asp 
    1040                 1045                 1050             


Pro Pro  Glu Ala Gln Val Gln  Ile Asp Arg Leu Ile  Asn Gly Arg 
    1055                 1060                 1065             


Leu Thr  Ala Leu Asn Ala Tyr  Val Ser Gln Gln Leu  Ser Asp Ile 
    1070                 1075                 1080             


Thr Leu  Ile Lys Ala Gly Ala  Ser Arg Ala Ile Glu  Lys Val Asn 
    1085                 1090                 1095             


Glu Cys  Val Lys Ser Gln Ser  Pro Arg Ile Asn Phe  Cys Gly Asn 
    1100                 1105                 1110             


Gly Asn  His Ile Leu Ser Leu  Val Gln Asn Ala Pro  Tyr Gly Leu 
    1115                 1120                 1125             


Leu Phe  Ile His Phe Ser Tyr  Lys Pro Thr Ser Phe  Lys Thr Val 
    1130                 1135                 1140             


Leu Val  Ser Pro Gly Leu Cys  Leu Ser Gly Asp Arg  Gly Ile Ala 
    1145                 1150                 1155             


Pro Lys  Gln Gly Tyr Phe Ile  Lys Gln Asn Asp Ser  Trp Met Phe 
    1160                 1165                 1170             


Thr Gly  Ser Ser Tyr Tyr Tyr  Pro Glu Pro Ile Ser  Asp Lys Asn 
    1175                 1180                 1185             


Val Val  Phe Met Asn Ser Cys  Ser Val Asn Phe Thr  Lys Ala Pro 
    1190                 1195                 1200             


Phe Ile  Tyr Leu Asn Asn Leu  Gln Ser Asn Leu Gln  Asp Leu Glu 
    1205                 1210                 1215             


Ala Glu  Leu Ser Gln Leu His  Lys Gln Gly Ser Gly  Gly Ser Gly 
    1220                 1225                 1230             


Asp Ile  Ile Lys Leu Leu Asn  Glu Gln Val Asn Lys  Glu Met Gln 
    1235                 1240                 1245             


Ser Ser  Asn Leu Tyr Met Ser  Met Ser Ser Trp Cys  Tyr Thr His 
    1250                 1255                 1260             


Ser Leu  Asp Gly Ala Gly Leu  Phe Leu Phe Asp His  Ala Ala Glu 
    1265                 1270                 1275             


Glu Tyr  Glu His Ala Lys Lys  Leu Ile Ile Phe Leu  Asn Glu Asn 
    1280                 1285                 1290             


Asn Val  Pro Val Gln Leu Thr  Ser Ile Ser Ala Pro  Glu His Lys 
    1295                 1300                 1305             


Phe Glu  Gly Leu Thr Gln Ile  Phe Gln Lys Ala Tyr  Glu His Glu 
    1310                 1315                 1320             


Gln His  Ile Ser Glu Ser Ile  Asn Asn Ile Val Asp  His Ala Ile 
    1325                 1330                 1335             


Lys Ser  Lys Asp His Ala Thr  Phe Asn Phe Leu Gln  Trp Tyr Val 
    1340                 1345                 1350             


Ala Glu  Gln His Glu Glu Glu  Val Leu Phe Lys Asp  Ile Leu Asp 
    1355                 1360                 1365             


Lys Ile  Glu Leu Ile Gly Asn  Glu Asn His Gly Leu  Tyr Leu Ala 
    1370                 1375                 1380             


Asp Gln  Tyr Val Lys Gly Ile  Ala Lys Ser Arg Lys  Ser Gly Ser 
    1385                 1390                 1395             


<210> 274
<211> 1398
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 274
Val Ile Gly Asp Phe Asn Cys Thr Asn Ser Phe Ile Asn Asp Tyr Asn 
1               5                   10                  15      


Lys Thr Ile Pro Arg Ile Ser Glu Asp Val Val Asp Val Ser Leu Gly 
            20                  25                  30          


Leu Gly Thr Tyr Tyr Val Leu Asn Arg Val Tyr Leu Asn Thr Thr Leu 
        35                  40                  45              


Leu Phe Thr Gly Tyr Phe Pro Lys Ser Gly Ala Asn Phe Arg Asp Leu 
    50                  55                  60                  


Ala Leu Lys Gly Ser Ile Tyr Leu Ser Thr Leu Trp Tyr Lys Pro Pro 
65                  70                  75                  80  


Phe Leu Ser Asp Phe Asn Asn Gly Ile Phe Ser Lys Val Lys Asn Thr 
                85                  90                  95      


Lys Leu Tyr Val Asn Asn Thr Leu Tyr Ser Glu Phe Ser Thr Ile Val 
            100                 105                 110         


Ile Gly Ser Val Phe Val Asn Thr Ser Tyr Thr Ile Val Val Gln Pro 
        115                 120                 125             


His Asn Gly Ile Leu Glu Ile Thr Ala Cys Gln Tyr Thr Met Cys Glu 
    130                 135                 140                 


Tyr Pro His Thr Val Cys Lys Ser Lys Gly Ser Ile Arg Asn Glu Ser 
145                 150                 155                 160 


Trp His Ile Asp Ser Ser Glu Pro Leu Cys Leu Phe Lys Lys Asn Phe 
                165                 170                 175     


Thr Tyr Asn Val Ser Ala Asp Trp Leu Tyr Phe His Phe Tyr Gln Glu 
            180                 185                 190         


Arg Gly Val Phe Tyr Ala Tyr Tyr Ala Asp Val Gly Met Pro Thr Thr 
        195                 200                 205             


Phe Leu Phe Ser Leu Tyr Leu Gly Thr Ile Leu Ser His Tyr Tyr Val 
    210                 215                 220                 


Met Pro Leu Thr Cys Asn Ala Ile Ser Ser Asn Thr Asp Asn Glu Thr 
225                 230                 235                 240 


Leu Glu Tyr Trp Val Thr Pro Leu Ser Arg Arg Gln Tyr Leu Leu Asn 
                245                 250                 255     


Phe Asp Glu His Gly Val Ile Thr Asn Ala Val Asp Cys Ser Ser Ser 
            260                 265                 270         


Phe Leu Ser Glu Ile Gln Cys Lys Thr Gln Ser Phe Ala Pro Asn Thr 
        275                 280                 285             


Gly Val Tyr Asp Leu Ser Gly Phe Thr Val Lys Pro Val Ala Thr Val 
    290                 295                 300                 


Tyr Arg Arg Ile Pro Asn Leu Pro Asp Cys Asp Ile Asp Asn Trp Leu 
305                 310                 315                 320 


Asn Asn Val Ser Val Pro Ser Pro Leu Asn Trp Glu Arg Arg Ile Phe 
                325                 330                 335     


Ser Asn Cys Asn Phe Asn Leu Ser Thr Leu Leu Arg Leu Val His Val 
            340                 345                 350         


Asp Ser Phe Ser Cys Asn Asn Leu Asp Lys Ser Lys Ile Phe Gly Ser 
        355                 360                 365             


Cys Phe Asn Ser Ile Thr Val Asp Lys Phe Ala Ile Pro Asn Arg Arg 
    370                 375                 380                 


Arg Asp Asp Leu Gln Leu Gly Ser Ser Gly Phe Leu Gln Ser Ser Asn 
385                 390                 395                 400 


Tyr Lys Ile Asp Ile Ser Ser Ser Ser Cys Gln Leu Tyr Tyr Ser Leu 
                405                 410                 415     


Pro Leu Val Asn Val Thr Ile Asn Asn Phe Asn Pro Ser Ser Trp Asn 
            420                 425                 430         


Arg Arg Tyr Gly Phe Gly Ser Phe Asn Leu Ser Ser Tyr Asp Val Val 
        435                 440                 445             


Tyr Ser Asp His Cys Phe Ser Val Asn Ser Asp Phe Cys Pro Cys Ala 
    450                 455                 460                 


Asp Pro Ser Val Val Asn Ser Cys Ala Lys Ser Lys Pro Pro Ser Ala 
465                 470                 475                 480 


Ile Cys Pro Ala Gly Thr Lys Tyr Arg His Cys Asp Leu Asp Thr Thr 
                485                 490                 495     


Leu Tyr Val Lys Asn Trp Cys Arg Cys Ser Cys Leu Pro Asp Pro Ile 
            500                 505                 510         


Ser Thr Tyr Ser Pro Asn Thr Cys Pro Gln Lys Lys Val Val Val Gly 
        515                 520                 525             


Ile Gly Glu His Cys Pro Gly Leu Gly Ile Asn Glu Glu Lys Cys Gly 
    530                 535                 540                 


Thr Gln Leu Asn His Ser Ser Cys Phe Cys Ser Pro Asp Ala Phe Leu 
545                 550                 555                 560 


Gly Trp Ser Phe Asp Ser Cys Ile Ser Asn Asn Arg Cys Asn Ile Phe 
                565                 570                 575     


Ser Asn Phe Ile Phe Asn Gly Ile Asn Ser Gly Thr Thr Cys Ser Asn 
            580                 585                 590         


Asp Leu Leu Tyr Ser Asn Thr Glu Ile Ser Thr Gly Val Cys Val Asn 
        595                 600                 605             


Tyr Asp Leu Tyr Gly Ile Thr Gly Gln Gly Ile Phe Lys Glu Val Ser 
    610                 615                 620                 


Ala Ala Tyr Tyr Asn Asn Trp Gln Asn Leu Leu Tyr Asp Ser Asn Gly 
625                 630                 635                 640 


Asn Ile Ile Gly Phe Lys Asp Phe Leu Thr Asn Lys Thr Tyr Thr Ile 
                645                 650                 655     


Leu Pro Cys Tyr Ser Gly Arg Val Ser Ala Ala Phe Tyr Gln Asn Ser 
            660                 665                 670         


Ser Ser Pro Ala Leu Leu Tyr Arg Asn Leu Lys Cys Ser Tyr Val Leu 
        675                 680                 685             


Asn Asn Ile Ser Phe Ile Ser Gln Pro Phe Tyr Phe Asp Ser Tyr Leu 
    690                 695                 700                 


Gly Cys Val Leu Asn Ala Val Asn Leu Thr Ser Tyr Ser Val Ser Ser 
705                 710                 715                 720 


Cys Asp Leu Arg Met Gly Ser Gly Phe Cys Ile Asp Tyr Ala Leu Pro 
                725                 730                 735     


Ser Ser Gly Gly Ser Gly Ser Gly Ile Ser Ser Pro Tyr Arg Phe Val 
            740                 745                 750         


Thr Phe Glu Pro Phe Asn Val Ser Phe Val Asn Asp Ser Val Glu Thr 
        755                 760                 765             


Val Gly Gly Leu Phe Glu Ile Gln Ile Pro Thr Asn Phe Thr Ile Ala 
    770                 775                 780                 


Gly His Glu Glu Phe Ile Gln Thr Ser Ser Pro Lys Val Thr Ile Asp 
785                 790                 795                 800 


Cys Ser Ala Phe Val Cys Ser Asn Tyr Ala Ala Cys His Asp Leu Leu 
                805                 810                 815     


Ser Glu Tyr Gly Thr Phe Cys Asp Asn Ile Asn Ser Ile Leu Asn Glu 
            820                 825                 830         


Val Asn Asp Leu Leu Asp Ile Thr Gln Leu Gln Val Ala Asn Ala Leu 
        835                 840                 845             


Met Gln Gly Val Thr Leu Ser Ser Asn Leu Asn Thr Asn Leu His Ser 
    850                 855                 860                 


Asp Val Asp Asn Ile Asp Phe Lys Ser Leu Leu Gly Cys Leu Gly Ser 
865                 870                 875                 880 


Gln Cys Gly Ser Ser Ser Arg Ser Leu Leu Glu Asp Leu Leu Phe Asn 
                885                 890                 895     


Lys Val Lys Leu Ser Asp Val Gly Phe Val Glu Ala Tyr Asn Asn Cys 
            900                 905                 910         


Thr Gly Gly Ser Glu Ile Arg Asp Leu Leu Cys Val Gln Ser Phe Asn 
        915                 920                 925             


Gly Ile Lys Val Leu Pro Pro Ile Leu Ser Glu Thr Gln Ile Ser Gly 
    930                 935                 940                 


Tyr Thr Thr Ala Ala Thr Val Ala Ala Met Phe Pro Pro Trp Ser Ala 
945                 950                 955                 960 


Ala Ala Gly Val Pro Phe Ser Leu Asn Val Gln Tyr Arg Ile Asn Gly 
                965                 970                 975     


Leu Gly Val Thr Met Asp Val Leu Asn Lys Asn Gln Lys Leu Ile Ala 
            980                 985                 990         


Asn Ala Phe Asn Lys Ala Leu Leu  Ser Ile Gln Asn Gly  Phe Thr Ala 
        995                 1000                 1005             


Thr Asn  Ser Ala Leu Ala Lys  Ile Gln Ser Val Val  Asn Ala Asn 
    1010                 1015                 1020             


Ala Gln  Ala Leu Asn Ser Leu  Leu Gln Gln Leu Phe  Asn Lys Phe 
    1025                 1030                 1035             


Gly Ala  Ile Ser Ser Ser Leu  Gln Glu Ile Leu Ser  Arg Leu Asp 
    1040                 1045                 1050             


Pro Pro  Glu Ala Gln Val Gln  Ile Asp Arg Leu Ile  Asn Gly Arg 
    1055                 1060                 1065             


Leu Thr  Ala Leu Asn Ala Tyr  Val Ser Gln Gln Leu  Ser Asp Ile 
    1070                 1075                 1080             


Thr Leu  Ile Lys Ala Gly Ala  Ser Arg Ala Ile Glu  Lys Val Asn 
    1085                 1090                 1095             


Glu Cys  Val Lys Ser Gln Ser  Pro Arg Ile Asn Phe  Cys Gly Asn 
    1100                 1105                 1110             


Gly Asn  His Ile Leu Ser Leu  Val Gln Asn Ala Pro  Tyr Gly Leu 
    1115                 1120                 1125             


Leu Phe  Ile His Phe Ser Tyr  Lys Pro Thr Ser Phe  Lys Thr Val 
    1130                 1135                 1140             


Leu Val  Ser Pro Gly Leu Cys  Leu Ser Gly Asp Arg  Gly Ile Ala 
    1145                 1150                 1155             


Pro Lys  Gln Gly Tyr Phe Ile  Lys Gln Asn Asp Ser  Trp Met Phe 
    1160                 1165                 1170             


Thr Gly  Ser Ser Tyr Tyr Tyr  Pro Glu Pro Ile Ser  Asp Lys Asn 
    1175                 1180                 1185             


Val Val  Phe Met Asn Ser Cys  Ser Val Asn Phe Thr  Lys Ala Pro 
    1190                 1195                 1200             


Phe Ile  Tyr Leu Asn Asn Ser  Ile Ser Asn Leu Gln  Asp Ile Glu 
    1205                 1210                 1215             


Ala Glu  Leu Ser Gln Ile His  Lys Gln Gly Ser Gly  Gly Ser Gly 
    1220                 1225                 1230             


Asp Ile  Ile Lys Leu Leu Asn  Glu Gln Val Asn Lys  Glu Met Gln 
    1235                 1240                 1245             


Ser Ser  Asn Leu Tyr Met Ser  Met Ser Ser Trp Cys  Tyr Thr His 
    1250                 1255                 1260             


Ser Leu  Asp Gly Ala Gly Leu  Phe Leu Phe Asp His  Ala Ala Glu 
    1265                 1270                 1275             


Glu Tyr  Glu His Ala Lys Lys  Leu Ile Ile Phe Leu  Asn Glu Asn 
    1280                 1285                 1290             


Asn Val  Pro Val Gln Leu Thr  Ser Ile Ser Ala Pro  Glu His Lys 
    1295                 1300                 1305             


Phe Glu  Gly Leu Thr Gln Ile  Phe Gln Lys Ala Tyr  Glu His Glu 
    1310                 1315                 1320             


Gln His  Ile Ser Glu Ser Ile  Asn Asn Ile Val Asp  His Ala Ile 
    1325                 1330                 1335             


Lys Ser  Lys Asp His Ala Thr  Phe Asn Phe Leu Gln  Trp Tyr Val 
    1340                 1345                 1350             


Ala Glu  Gln His Glu Glu Glu  Val Leu Phe Lys Asp  Ile Leu Asp 
    1355                 1360                 1365             


Lys Ile  Glu Leu Ile Gly Asn  Glu Asn His Gly Leu  Tyr Leu Ala 
    1370                 1375                 1380             


Asp Gln  Tyr Val Lys Gly Ile  Ala Lys Ser Arg Lys  Ser Gly Ser 
    1385                 1390                 1395             


<210> 275
<211> 1398
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 275
Val Ile Gly Asp Phe Asn Cys Thr Asn Ser Phe Ile Asn Asp Tyr Asn 
1               5                   10                  15      


Lys Thr Ile Pro Arg Ile Ser Glu Asp Val Val Asp Val Ser Leu Gly 
            20                  25                  30          


Leu Gly Thr Tyr Tyr Val Leu Asn Arg Val Tyr Leu Asn Thr Thr Leu 
        35                  40                  45              


Leu Phe Thr Gly Tyr Phe Pro Lys Ser Gly Ala Asn Phe Arg Asp Leu 
    50                  55                  60                  


Ala Leu Lys Gly Ser Ile Tyr Leu Ser Thr Leu Trp Tyr Lys Pro Pro 
65                  70                  75                  80  


Phe Leu Ser Asp Phe Asn Asn Gly Ile Phe Ser Lys Val Lys Asn Thr 
                85                  90                  95      


Lys Leu Tyr Val Asn Asn Thr Leu Tyr Ser Glu Phe Ser Thr Ile Val 
            100                 105                 110         


Ile Gly Ser Val Phe Val Asn Thr Ser Tyr Thr Ile Val Val Gln Pro 
        115                 120                 125             


His Asn Gly Ile Leu Glu Ile Thr Ala Cys Gln Tyr Thr Met Cys Glu 
    130                 135                 140                 


Tyr Pro His Thr Val Cys Lys Ser Lys Gly Ser Ile Arg Asn Glu Ser 
145                 150                 155                 160 


Trp His Ile Asp Ser Ser Glu Pro Leu Cys Leu Phe Lys Lys Asn Phe 
                165                 170                 175     


Thr Tyr Asn Val Ser Ala Asp Trp Leu Tyr Phe His Phe Tyr Gln Glu 
            180                 185                 190         


Arg Gly Val Phe Tyr Ala Tyr Tyr Ala Asp Val Gly Met Pro Thr Thr 
        195                 200                 205             


Phe Leu Phe Ser Leu Tyr Leu Gly Thr Ile Leu Ser His Tyr Tyr Val 
    210                 215                 220                 


Met Pro Leu Thr Cys Asn Ala Ile Ser Ser Asn Thr Asp Asn Glu Thr 
225                 230                 235                 240 


Leu Glu Tyr Trp Val Thr Pro Leu Ser Arg Arg Gln Tyr Leu Leu Asn 
                245                 250                 255     


Phe Asp Glu His Gly Val Ile Thr Asn Ala Val Asp Cys Ser Ser Ser 
            260                 265                 270         


Phe Leu Ser Glu Ile Gln Cys Lys Thr Gln Ser Phe Ala Pro Asn Thr 
        275                 280                 285             


Gly Val Tyr Asp Leu Ser Gly Phe Thr Val Lys Pro Val Ala Thr Val 
    290                 295                 300                 


Tyr Arg Arg Ile Pro Asn Leu Pro Asp Cys Asp Ile Asp Asn Trp Leu 
305                 310                 315                 320 


Asn Asn Val Ser Val Pro Ser Pro Leu Asn Trp Glu Arg Arg Ile Phe 
                325                 330                 335     


Ser Asn Cys Asn Phe Asn Leu Ser Thr Leu Leu Arg Leu Val His Val 
            340                 345                 350         


Asp Ser Phe Ser Cys Asn Asn Leu Asp Lys Ser Lys Ile Phe Gly Ser 
        355                 360                 365             


Cys Phe Asn Ser Ile Thr Val Asp Lys Phe Ala Ile Pro Asn Arg Arg 
    370                 375                 380                 


Arg Asp Asp Leu Gln Leu Gly Ser Ser Gly Phe Leu Gln Ser Ser Asn 
385                 390                 395                 400 


Tyr Lys Ile Asp Ile Ser Ser Ser Ser Cys Gln Leu Tyr Tyr Ser Leu 
                405                 410                 415     


Pro Leu Val Asn Val Thr Ile Asn Asn Phe Asn Pro Ser Ser Trp Asn 
            420                 425                 430         


Arg Arg Tyr Gly Phe Gly Ser Phe Asn Leu Ser Ser Tyr Asp Val Val 
        435                 440                 445             


Tyr Ser Asp His Cys Phe Ser Val Asn Ser Asp Phe Cys Pro Cys Ala 
    450                 455                 460                 


Asp Pro Ser Val Val Asn Ser Cys Ala Lys Ser Lys Pro Pro Ser Ala 
465                 470                 475                 480 


Ile Cys Pro Ala Gly Thr Lys Tyr Arg His Cys Asp Leu Asp Thr Thr 
                485                 490                 495     


Leu Tyr Val Lys Asn Trp Cys Arg Cys Ser Cys Leu Pro Asp Pro Ile 
            500                 505                 510         


Ser Thr Tyr Ser Pro Asn Thr Cys Pro Gln Lys Lys Val Val Val Gly 
        515                 520                 525             


Ile Gly Glu His Cys Pro Gly Leu Gly Ile Asn Glu Glu Lys Cys Gly 
    530                 535                 540                 


Thr Gln Leu Asn His Ser Ser Cys Phe Cys Ser Pro Asp Ala Phe Leu 
545                 550                 555                 560 


Gly Trp Ser Phe Asp Ser Cys Ile Ser Asn Asn Arg Cys Asn Ile Phe 
                565                 570                 575     


Ser Asn Phe Ile Phe Asn Gly Ile Asn Ser Gly Thr Thr Cys Ser Asn 
            580                 585                 590         


Asp Leu Leu Tyr Ser Asn Thr Glu Ile Ser Thr Gly Val Cys Val Asn 
        595                 600                 605             


Tyr Asp Leu Tyr Gly Ile Thr Gly Gln Gly Ile Phe Lys Glu Val Ser 
    610                 615                 620                 


Ala Ala Tyr Tyr Asn Asn Trp Gln Asn Leu Leu Tyr Asp Ser Asn Gly 
625                 630                 635                 640 


Asn Ile Ile Gly Phe Lys Asp Phe Leu Thr Asn Lys Thr Tyr Thr Ile 
                645                 650                 655     


Leu Pro Cys Tyr Ser Gly Arg Val Ser Ala Ala Phe Tyr Gln Asn Ser 
            660                 665                 670         


Ser Ser Pro Ala Leu Leu Tyr Arg Asn Leu Lys Cys Ser Tyr Val Leu 
        675                 680                 685             


Asn Asn Ile Ser Phe Ile Ser Gln Pro Phe Tyr Phe Asp Ser Tyr Leu 
    690                 695                 700                 


Gly Cys Val Leu Asn Ala Val Asn Leu Thr Ser Tyr Ser Val Ser Ser 
705                 710                 715                 720 


Cys Asp Leu Arg Met Gly Ser Gly Phe Cys Ile Asp Tyr Ala Leu Pro 
                725                 730                 735     


Ser Ser Gly Gly Ser Gly Ser Gly Ile Ser Ser Pro Tyr Arg Phe Val 
            740                 745                 750         


Thr Phe Glu Pro Phe Asn Val Ser Phe Val Asn Asp Ser Val Glu Thr 
        755                 760                 765             


Val Gly Gly Leu Phe Glu Ile Gln Ile Pro Thr Asn Phe Thr Ile Ala 
    770                 775                 780                 


Gly His Glu Glu Phe Ile Gln Thr Ser Ser Pro Lys Val Thr Ile Asp 
785                 790                 795                 800 


Cys Ser Ala Phe Val Cys Ser Asn Tyr Ala Ala Cys His Asp Leu Leu 
                805                 810                 815     


Ser Glu Tyr Gly Thr Phe Cys Asp Asn Ile Asn Ser Ile Leu Asn Glu 
            820                 825                 830         


Val Asn Asp Leu Leu Asp Ile Thr Gln Leu Gln Val Ala Asn Ala Leu 
        835                 840                 845             


Met Gln Gly Val Thr Leu Ser Ser Asn Leu Asn Thr Asn Leu His Ser 
    850                 855                 860                 


Asp Val Asp Asn Ile Asp Phe Lys Ser Leu Leu Gly Cys Leu Gly Ser 
865                 870                 875                 880 


Gln Cys Gly Ser Ser Ser Arg Ser Leu Leu Glu Asp Leu Leu Phe Asn 
                885                 890                 895     


Lys Val Lys Leu Ser Asp Val Gly Phe Val Glu Ala Tyr Asn Asn Cys 
            900                 905                 910         


Thr Gly Gly Ser Glu Ile Arg Asp Leu Leu Cys Val Gln Ser Phe Asn 
        915                 920                 925             


Gly Ile Lys Val Leu Pro Pro Ile Leu Ser Glu Thr Gln Ile Ser Gly 
    930                 935                 940                 


Tyr Thr Thr Ala Ala Thr Val Ala Ala Met Phe Pro Pro Trp Ser Ala 
945                 950                 955                 960 


Ala Ala Gly Val Pro Phe Ser Leu Asn Val Gln Tyr Arg Ile Asn Gly 
                965                 970                 975     


Leu Gly Val Thr Met Asp Val Leu Asn Lys Asn Gln Lys Leu Ile Ala 
            980                 985                 990         


Asn Ala Phe Asn Lys Ala Leu Leu  Ser Ile Gln Asn Gly  Phe Thr Ala 
        995                 1000                 1005             


Thr Asn  Ser Ala Leu Ala Lys  Ile Gln Ser Val Val  Asn Ala Asn 
    1010                 1015                 1020             


Ala Gln  Ala Leu Asn Ser Leu  Leu Gln Gln Leu Phe  Asn Lys Phe 
    1025                 1030                 1035             


Gly Ala  Ile Ser Ser Ser Leu  Gln Glu Ile Leu Ser  Arg Leu Asp 
    1040                 1045                 1050             


Pro Pro  Glu Ala Gln Val Gln  Ile Asp Arg Leu Ile  Asn Gly Arg 
    1055                 1060                 1065             


Leu Thr  Ala Leu Asn Ala Tyr  Val Ser Gln Gln Leu  Ser Asp Ile 
    1070                 1075                 1080             


Thr Leu  Ile Lys Ala Gly Ala  Ser Arg Ala Ile Glu  Lys Val Asn 
    1085                 1090                 1095             


Glu Cys  Val Lys Ser Gln Ser  Pro Arg Ile Asn Phe  Cys Gly Asn 
    1100                 1105                 1110             


Gly Asn  His Ile Leu Ser Leu  Val Gln Asn Ala Pro  Tyr Gly Leu 
    1115                 1120                 1125             


Leu Phe  Ile His Phe Ser Tyr  Lys Pro Thr Ser Phe  Lys Thr Val 
    1130                 1135                 1140             


Leu Val  Ser Pro Gly Leu Cys  Leu Ser Gly Asp Arg  Gly Ile Ala 
    1145                 1150                 1155             


Pro Lys  Gln Gly Tyr Phe Ile  Lys Gln Asn Asp Ser  Trp Met Phe 
    1160                 1165                 1170             


Thr Gly  Ser Ser Tyr Tyr Tyr  Pro Glu Pro Ile Ser  Asp Lys Asn 
    1175                 1180                 1185             


Val Val  Phe Met Asn Ser Cys  Ser Val Asn Phe Thr  Lys Ala Pro 
    1190                 1195                 1200             


Phe Ile  Tyr Leu Asn Asn Ser  Ile Ser Asn Leu Gln  Asp Leu Glu 
    1205                 1210                 1215             


Ala Glu  Leu Ser Gln Leu His  Lys Gln Gly Ser Gly  Gly Ser Gly 
    1220                 1225                 1230             


Asp Ile  Ile Lys Leu Leu Asn  Glu Gln Val Asn Lys  Glu Met Gln 
    1235                 1240                 1245             


Ser Ser  Asn Leu Tyr Met Ser  Met Ser Ser Trp Cys  Tyr Thr His 
    1250                 1255                 1260             


Ser Leu  Asp Gly Ala Gly Leu  Phe Leu Phe Asp His  Ala Ala Glu 
    1265                 1270                 1275             


Glu Tyr  Glu His Ala Lys Lys  Leu Ile Ile Phe Leu  Asn Glu Asn 
    1280                 1285                 1290             


Asn Val  Pro Val Gln Leu Thr  Ser Ile Ser Ala Pro  Glu His Lys 
    1295                 1300                 1305             


Phe Glu  Gly Leu Thr Gln Ile  Phe Gln Lys Ala Tyr  Glu His Glu 
    1310                 1315                 1320             


Gln His  Ile Ser Glu Ser Ile  Asn Asn Ile Val Asp  His Ala Ile 
    1325                 1330                 1335             


Lys Ser  Lys Asp His Ala Thr  Phe Asn Phe Leu Gln  Trp Tyr Val 
    1340                 1345                 1350             


Ala Glu  Gln His Glu Glu Glu  Val Leu Phe Lys Asp  Ile Leu Asp 
    1355                 1360                 1365             


Lys Ile  Glu Leu Ile Gly Asn  Glu Asn His Gly Leu  Tyr Leu Ala 
    1370                 1375                 1380             


Asp Gln  Tyr Val Lys Gly Ile  Ala Lys Ser Arg Lys  Ser Gly Ser 
    1385                 1390                 1395             


<210> 276
<211> 390
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 276
Glu Gly Val Glu Cys Asp Phe Ser Pro Leu Leu Ser Gly Thr Pro Pro 
1               5                   10                  15      


Gln Val Tyr Asn Phe Lys Arg Leu Val Phe Thr Asn Cys Asn Tyr Asn 
            20                  25                  30          


Leu Thr Lys Leu Leu Ser Leu Phe Ser Val Asn Asp Phe Thr Cys Ser 
        35                  40                  45              


Gln Ile Ser Pro Ala Ala Ile Ala Ser Asn Cys Tyr Ser Ser Leu Ile 
    50                  55                  60                  


Leu Asp Tyr Phe Ser Tyr Pro Leu Ser Met Lys Ser Asp Leu Ser Val 
65                  70                  75                  80  


Ser Ser Ala Gly Pro Ile Ser Gln Phe Asn Tyr Lys Gln Ser Phe Ser 
                85                  90                  95      


Asn Pro Thr Cys Leu Ile Leu Ala Thr Val Pro His Asn Leu Thr Thr 
            100                 105                 110         


Ile Thr Lys Pro Leu Lys Tyr Ser Tyr Ile Asn Lys Cys Ser Arg Leu 
        115                 120                 125             


Leu Ser Asp Asp Arg Thr Glu Val Pro Gln Leu Val Asn Ala Asn Gln 
    130                 135                 140                 


Tyr Ser Pro Cys Val Ser Ile Val Pro Ser Thr Val Trp Glu Asp Gly 
145                 150                 155                 160 


Asp Tyr Tyr Arg Lys Gln Leu Ser Pro Leu Glu Gly Gly Gly Trp Leu 
                165                 170                 175     


Val Ala Ser Gly Ser Thr Val Ala Met Thr Glu Gln Leu Gln Met Gly 
            180                 185                 190         


Phe Gly Ile Thr Val Gln Tyr Gly Thr Asp Thr Asn Ser Val Cys Pro 
        195                 200                 205             


Lys Gly Ser Gly Gly Gly Gly Glu Ser Gln Val Arg Gln Gln Phe Ser 
    210                 215                 220                 


Lys Asp Ile Glu Lys Leu Leu Asn Glu Gln Val Asn Lys Glu Met Gln 
225                 230                 235                 240 


Ser Ser Asn Leu Tyr Met Ser Met Ser Ser Trp Cys Tyr Thr His Ser 
                245                 250                 255     


Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp His Ala Ala Glu Glu Tyr 
            260                 265                 270         


Glu His Ala Lys Lys Leu Ile Ile Phe Leu Asn Glu Asn Asn Val Pro 
        275                 280                 285             


Val Gln Leu Thr Ser Ile Ser Ala Pro Glu His Lys Phe Glu Gly Leu 
    290                 295                 300                 


Thr Gln Ile Phe Gln Lys Ala Tyr Glu His Glu Gln His Ile Ser Glu 
305                 310                 315                 320 


Ser Ile Asn Asn Ile Val Asp His Ala Ile Lys Ser Lys Asp His Ala 
                325                 330                 335     


Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala Glu Gln His Glu Glu Glu 
            340                 345                 350         


Val Leu Phe Lys Asp Ile Leu Asp Lys Ile Glu Leu Ile Gly Asn Glu 
        355                 360                 365             


Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr Val Lys Gly Ile Ala Lys 
    370                 375                 380                 


Ser Arg Lys Ser Gly Ser 
385                 390 


<210> 277
<211> 387
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 277
Glu Cys Asp Phe Ser Pro Leu Leu Ser Gly Thr Pro Pro Gln Val Tyr 
1               5                   10                  15      


Asn Phe Lys Arg Leu Val Phe Thr Asn Cys Asn Tyr Asn Leu Thr Lys 
            20                  25                  30          


Leu Leu Ser Leu Phe Ser Val Asn Asp Phe Thr Cys Ser Gln Ile Ser 
        35                  40                  45              


Pro Ala Ala Ile Ala Ser Asn Cys Tyr Ser Ser Leu Ile Leu Asp Tyr 
    50                  55                  60                  


Phe Ser Tyr Pro Leu Ser Met Lys Ser Asp Leu Ser Val Ser Ser Ala 
65                  70                  75                  80  


Gly Pro Ile Ser Gln Phe Asn Tyr Lys Gln Ser Phe Ser Asn Pro Thr 
                85                  90                  95      


Cys Leu Ile Leu Ala Thr Val Pro His Asn Leu Thr Thr Ile Thr Lys 
            100                 105                 110         


Pro Leu Lys Tyr Ser Tyr Ile Asn Lys Cys Ser Arg Leu Leu Ser Asp 
        115                 120                 125             


Asp Arg Thr Glu Val Pro Gln Leu Val Asn Ala Asn Gln Tyr Ser Pro 
    130                 135                 140                 


Cys Val Ser Ile Val Pro Ser Thr Val Trp Glu Asp Gly Asp Tyr Tyr 
145                 150                 155                 160 


Arg Lys Gln Leu Ser Pro Leu Glu Gly Gly Gly Trp Leu Val Ala Ser 
                165                 170                 175     


Gly Ser Thr Val Ala Met Thr Glu Gln Leu Gln Met Gly Phe Gly Ile 
            180                 185                 190         


Thr Val Gln Tyr Gly Thr Asp Thr Asn Ser Val Cys Pro Lys Gly Ser 
        195                 200                 205             


Gly Gly Gly Gly Glu Ser Gln Val Arg Gln Gln Phe Ser Lys Asp Ile 
    210                 215                 220                 


Glu Lys Leu Leu Asn Glu Gln Val Asn Lys Glu Met Gln Ser Ser Asn 
225                 230                 235                 240 


Leu Tyr Met Ser Met Ser Ser Trp Cys Tyr Thr His Ser Leu Asp Gly 
                245                 250                 255     


Ala Gly Leu Phe Leu Phe Asp His Ala Ala Glu Glu Tyr Glu His Ala 
            260                 265                 270         


Lys Lys Leu Ile Ile Phe Leu Asn Glu Asn Asn Val Pro Val Gln Leu 
        275                 280                 285             


Thr Ser Ile Ser Ala Pro Glu His Lys Phe Glu Gly Leu Thr Gln Ile 
    290                 295                 300                 


Phe Gln Lys Ala Tyr Glu His Glu Gln His Ile Ser Glu Ser Ile Asn 
305                 310                 315                 320 


Asn Ile Val Asp His Ala Ile Lys Ser Lys Asp His Ala Thr Phe Asn 
                325                 330                 335     


Phe Leu Gln Trp Tyr Val Ala Glu Gln His Glu Glu Glu Val Leu Phe 
            340                 345                 350         


Lys Asp Ile Leu Asp Lys Ile Glu Leu Ile Gly Asn Glu Asn His Gly 
        355                 360                 365             


Leu Tyr Leu Ala Asp Gln Tyr Val Lys Gly Ile Ala Lys Ser Arg Lys 
    370                 375                 380                 


Ser Gly Ser 
385         


<210> 278
<211> 390
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 278
Glu Gly Val Glu Cys Asp Phe Ser Pro Leu Leu Ser Gly Thr Pro Pro 
1               5                   10                  15      


Gln Val Tyr Asn Phe Lys Arg Leu Val Phe Thr Asn Cys Asn Tyr Asn 
            20                  25                  30          


Leu Thr Lys Leu Leu Ser Leu Phe Ser Val Asn Asp Phe Thr Cys Ser 
        35                  40                  45              


Gln Ile Ser Pro Ala Ala Ile Ala Ser Asn Cys Tyr Ser Ser Leu Ile 
    50                  55                  60                  


Leu Asp Tyr Phe Ser Tyr Pro Leu Ser Met Lys Ser Asp Leu Ser Val 
65                  70                  75                  80  


Ser Ser Ala Gly Pro Ile Ser Gln Phe Asn Tyr Lys Gln Ser Phe Ser 
                85                  90                  95      


Asn Pro Thr Cys Leu Ile Leu Ala Thr Val Pro His Asn Leu Thr Thr 
            100                 105                 110         


Ile Thr Lys Pro Leu Lys Tyr Ser Tyr Ile Asn Lys Cys Ser Arg Leu 
        115                 120                 125             


Leu Ser Asp Asp Arg Thr Glu Val Pro Gln Leu Val Asn Ala Asn Gln 
    130                 135                 140                 


Tyr Ser Pro Cys Val Ser Ile Val Pro Ser Thr Val Trp Glu Asp Gly 
145                 150                 155                 160 


Asp Tyr Tyr Arg Lys Gln Leu Ser Pro Leu Glu Gly Gly Gly Trp Leu 
                165                 170                 175     


Val Ala Ser Gly Ser Thr Val Ala Met Thr Glu Gln Leu Gln Met Gly 
            180                 185                 190         


Phe Gly Ile Thr Val Gln Asn Gly Thr Asp Thr Asn Ser Val Cys Pro 
        195                 200                 205             


Lys Gly Ser Gly Gly Gly Gly Glu Ser Gln Val Arg Gln Gln Phe Ser 
    210                 215                 220                 


Lys Asp Ile Glu Lys Leu Leu Asn Glu Gln Val Asn Lys Glu Met Gln 
225                 230                 235                 240 


Ser Ser Asn Leu Tyr Met Ser Met Ser Ser Trp Cys Tyr Thr His Ser 
                245                 250                 255     


Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp His Ala Ala Glu Glu Tyr 
            260                 265                 270         


Glu His Ala Lys Lys Leu Ile Ile Phe Leu Asn Glu Asn Asn Val Pro 
        275                 280                 285             


Val Gln Leu Thr Ser Ile Ser Ala Pro Glu His Lys Phe Glu Gly Leu 
    290                 295                 300                 


Thr Gln Ile Phe Gln Lys Ala Tyr Glu His Glu Gln His Ile Ser Glu 
305                 310                 315                 320 


Ser Ile Asn Asn Ile Val Asp His Ala Ile Lys Ser Lys Asp His Ala 
                325                 330                 335     


Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala Glu Gln His Glu Glu Glu 
            340                 345                 350         


Val Leu Phe Lys Asp Ile Leu Asp Lys Ile Glu Leu Ile Gly Asn Glu 
        355                 360                 365             


Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr Val Lys Gly Ile Ala Lys 
    370                 375                 380                 


Ser Arg Lys Ser Gly Ser 
385                 390 


<210> 279
<211> 390
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 279
Glu Gly Val Glu Cys Asp Phe Ser Pro Leu Leu Ser Gly Thr Pro Pro 
1               5                   10                  15      


Gln Val Tyr Asn Phe Lys Arg Leu Val Phe Thr Asn Cys Asn Tyr Asn 
            20                  25                  30          


Leu Thr Lys Leu Leu Ser Leu Phe Ser Val Asn Asp Phe Thr Cys Ser 
        35                  40                  45              


Gln Ile Ser Pro Ala Ala Ile Ala Ser Asn Cys Tyr Ser Ser Leu Ile 
    50                  55                  60                  


Leu Asp Tyr Phe Ser Tyr Pro Leu Ser Met Lys Ser Asp Leu Ser Val 
65                  70                  75                  80  


Ser Ser Ala Gly Pro Ile Ser Gln Phe Asn Tyr Lys Gln Ser Phe Ser 
                85                  90                  95      


Asn Pro Thr Cys Leu Ile Leu Ala Thr Val Pro His Asn Leu Thr Thr 
            100                 105                 110         


Ile Thr Lys Pro Leu Lys Tyr Ser Tyr Ile Asn Lys Cys Ser Arg Leu 
        115                 120                 125             


Leu Ser Asp Asp Arg Thr Glu Val Pro Gln Leu Val Asn Ala Asn Gln 
    130                 135                 140                 


Tyr Ser Pro Cys Val Ser Ile Val Pro Ser Thr Val Trp Glu Asp Gly 
145                 150                 155                 160 


Asp Tyr Tyr Arg Lys Gln Leu Ser Pro Leu Glu Gly Gly Gly Trp Leu 
                165                 170                 175     


Val Ala Ser Gly Ser Thr Val Ala Met Thr Glu Gln Leu Gln Met Gly 
            180                 185                 190         


Phe Gly Ile Thr Val Gln Arg Gly Thr Asp Thr Asn Ser Val Cys Pro 
        195                 200                 205             


Lys Gly Ser Gly Gly Gly Gly Glu Ser Gln Val Arg Gln Gln Phe Ser 
    210                 215                 220                 


Lys Asp Ile Glu Lys Leu Leu Asn Glu Gln Val Asn Lys Glu Met Gln 
225                 230                 235                 240 


Ser Ser Asn Leu Tyr Met Ser Met Ser Ser Trp Cys Tyr Thr His Ser 
                245                 250                 255     


Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp His Ala Ala Glu Glu Tyr 
            260                 265                 270         


Glu His Ala Lys Lys Leu Ile Ile Phe Leu Asn Glu Asn Asn Val Pro 
        275                 280                 285             


Val Gln Leu Thr Ser Ile Ser Ala Pro Glu His Lys Phe Glu Gly Leu 
    290                 295                 300                 


Thr Gln Ile Phe Gln Lys Ala Tyr Glu His Glu Gln His Ile Ser Glu 
305                 310                 315                 320 


Ser Ile Asn Asn Ile Val Asp His Ala Ile Lys Ser Lys Asp His Ala 
                325                 330                 335     


Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala Glu Gln His Glu Glu Glu 
            340                 345                 350         


Val Leu Phe Lys Asp Ile Leu Asp Lys Ile Glu Leu Ile Gly Asn Glu 
        355                 360                 365             


Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr Val Lys Gly Ile Ala Lys 
    370                 375                 380                 


Ser Arg Lys Ser Gly Ser 
385                 390 


<210> 280
<211> 387
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 280
Glu Cys Asp Phe Ser Pro Leu Leu Ser Gly Thr Pro Pro Gln Val Tyr 
1               5                   10                  15      


Asn Phe Lys Arg Leu Val Phe Thr Asn Cys Asn Tyr Asn Leu Thr Lys 
            20                  25                  30          


Leu Leu Ser Leu Phe Ser Val Asn Asp Phe Thr Cys Ser Gln Ile Ser 
        35                  40                  45              


Pro Ala Ala Ile Ala Ser Asn Cys Tyr Ser Ser Leu Ile Leu Asp Tyr 
    50                  55                  60                  


Phe Ser Tyr Pro Leu Ser Met Lys Ser Asp Leu Ser Val Ser Ser Ala 
65                  70                  75                  80  


Gly Pro Ile Ser Gln Phe Asn Tyr Lys Gln Ser Phe Ser Asn Pro Thr 
                85                  90                  95      


Cys Leu Ile Leu Ala Thr Val Pro His Asn Leu Thr Thr Ile Thr Lys 
            100                 105                 110         


Pro Leu Lys Tyr Ser Tyr Ile Asn Lys Cys Ser Arg Leu Leu Ser Asp 
        115                 120                 125             


Asp Arg Thr Glu Val Pro Gln Leu Val Asn Ala Asn Gln Tyr Ser Pro 
    130                 135                 140                 


Cys Val Ser Ile Val Pro Ser Thr Val Trp Glu Asp Gly Asp Tyr Tyr 
145                 150                 155                 160 


Arg Lys Gln Leu Ser Pro Leu Glu Gly Gly Gly Trp Leu Val Ala Ser 
                165                 170                 175     


Gly Ser Thr Val Ala Met Thr Glu Gln Leu Gln Met Gly Phe Gly Ile 
            180                 185                 190         


Thr Val Gln Asn Gly Thr Asp Thr Asn Ser Val Cys Pro Lys Gly Ser 
        195                 200                 205             


Gly Gly Gly Gly Glu Ser Gln Val Arg Gln Gln Phe Ser Lys Asp Ile 
    210                 215                 220                 


Glu Lys Leu Leu Asn Glu Gln Val Asn Lys Glu Met Gln Ser Ser Asn 
225                 230                 235                 240 


Leu Tyr Met Ser Met Ser Ser Trp Cys Tyr Thr His Ser Leu Asp Gly 
                245                 250                 255     


Ala Gly Leu Phe Leu Phe Asp His Ala Ala Glu Glu Tyr Glu His Ala 
            260                 265                 270         


Lys Lys Leu Ile Ile Phe Leu Asn Glu Asn Asn Val Pro Val Gln Leu 
        275                 280                 285             


Thr Ser Ile Ser Ala Pro Glu His Lys Phe Glu Gly Leu Thr Gln Ile 
    290                 295                 300                 


Phe Gln Lys Ala Tyr Glu His Glu Gln His Ile Ser Glu Ser Ile Asn 
305                 310                 315                 320 


Asn Ile Val Asp His Ala Ile Lys Ser Lys Asp His Ala Thr Phe Asn 
                325                 330                 335     


Phe Leu Gln Trp Tyr Val Ala Glu Gln His Glu Glu Glu Val Leu Phe 
            340                 345                 350         


Lys Asp Ile Leu Asp Lys Ile Glu Leu Ile Gly Asn Glu Asn His Gly 
        355                 360                 365             


Leu Tyr Leu Ala Asp Gln Tyr Val Lys Gly Ile Ala Lys Ser Arg Lys 
    370                 375                 380                 


Ser Gly Ser 
385         


<210> 281
<211> 387
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 281
Glu Cys Asp Phe Ser Pro Leu Leu Ser Gly Thr Pro Pro Gln Val Tyr 
1               5                   10                  15      


Asn Phe Lys Arg Leu Val Phe Thr Asn Cys Asn Tyr Asn Leu Thr Lys 
            20                  25                  30          


Leu Leu Ser Leu Phe Ser Val Asn Asp Phe Thr Cys Ser Gln Ile Ser 
        35                  40                  45              


Pro Ala Ala Ile Ala Ser Asn Cys Tyr Ser Ser Leu Ile Leu Asp Tyr 
    50                  55                  60                  


Phe Ser Tyr Pro Leu Ser Met Lys Ser Asp Leu Ser Val Ser Ser Ala 
65                  70                  75                  80  


Gly Pro Ile Ser Gln Phe Asn Tyr Lys Gln Ser Phe Ser Asn Pro Thr 
                85                  90                  95      


Cys Leu Ile Leu Ala Thr Val Pro His Asn Leu Thr Thr Ile Thr Lys 
            100                 105                 110         


Pro Leu Lys Tyr Ser Tyr Ile Asn Lys Cys Ser Arg Leu Leu Ser Asp 
        115                 120                 125             


Asp Arg Thr Glu Val Pro Gln Leu Val Asn Ala Asn Gln Tyr Ser Pro 
    130                 135                 140                 


Cys Val Ser Ile Val Pro Ser Thr Val Trp Glu Asp Gly Asp Tyr Tyr 
145                 150                 155                 160 


Arg Lys Gln Leu Ser Pro Leu Glu Gly Gly Gly Trp Leu Val Ala Ser 
                165                 170                 175     


Gly Ser Thr Val Ala Met Thr Glu Gln Leu Gln Met Gly Phe Gly Ile 
            180                 185                 190         


Thr Val Gln Arg Gly Thr Asp Thr Asn Ser Val Cys Pro Lys Gly Ser 
        195                 200                 205             


Gly Gly Gly Gly Glu Ser Gln Val Arg Gln Gln Phe Ser Lys Asp Ile 
    210                 215                 220                 


Glu Lys Leu Leu Asn Glu Gln Val Asn Lys Glu Met Gln Ser Ser Asn 
225                 230                 235                 240 


Leu Tyr Met Ser Met Ser Ser Trp Cys Tyr Thr His Ser Leu Asp Gly 
                245                 250                 255     


Ala Gly Leu Phe Leu Phe Asp His Ala Ala Glu Glu Tyr Glu His Ala 
            260                 265                 270         


Lys Lys Leu Ile Ile Phe Leu Asn Glu Asn Asn Val Pro Val Gln Leu 
        275                 280                 285             


Thr Ser Ile Ser Ala Pro Glu His Lys Phe Glu Gly Leu Thr Gln Ile 
    290                 295                 300                 


Phe Gln Lys Ala Tyr Glu His Glu Gln His Ile Ser Glu Ser Ile Asn 
305                 310                 315                 320 


Asn Ile Val Asp His Ala Ile Lys Ser Lys Asp His Ala Thr Phe Asn 
                325                 330                 335     


Phe Leu Gln Trp Tyr Val Ala Glu Gln His Glu Glu Glu Val Leu Phe 
            340                 345                 350         


Lys Asp Ile Leu Asp Lys Ile Glu Leu Ile Gly Asn Glu Asn His Gly 
        355                 360                 365             


Leu Tyr Leu Ala Asp Gln Tyr Val Lys Gly Ile Ala Lys Ser Arg Lys 
    370                 375                 380                 


Ser Gly Ser 
385         


<210> 282
<211> 831
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 282
atggactcta agggcagctc ccagaagggc agcaggctgc tgctgctgct ggtggtgagc       60

aacctgctgc tgcctcaggg cgtggtgggc aacatcacca atctgtgccc attcggcgag      120

gtgtttaatg ccacacgctt cgcctccgtg tatgcctgga accggaagag aatcagcaat      180

tgcgtggccg actattccgt gctgtacaac tctgccagct tctccacctt taagtgctat      240

ggcgtgagcc ctaccaagct gaacgacctg tgcttcacaa acgtgtacgc cgactccttt      300

gtgatccggg gcgatgaggt gagacagatc gcaccaggac agaccggcaa gatcgcagac      360

tacaactata agctgcctga cgacttcacc ggctgcgtga tcgcctggaa ttccaacaat      420

ctggattcta aagtgggcgg caactacaat tatctgtaca ggctgttccg caagagcaac      480

ctgaagccat ttgagcggga tatctccacc gagatctacc aggccggctc tacaccctgc      540

aacggcgtgg agggcttcaa ttgttatttt cctctgcagt cctacggctt ccagccaacc      600

aatggcgtgg gctatcagcc ctaccgggtg gtggtgctgt cttttgagct gctgcacgca      660

ccagcaaccg tgtgcggacc tctggaggtg ctgttccagg gaccatctgc ctggagccac      720

ccacagtttg agaagggagg aggctctgga ggaggctccg gaggctctgc ctggagccac      780

ccccagttcg agaagggcag ccatcatcat caccaccacc accactgatg a               831


<210> 283
<211> 245
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 283
Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg 
1               5                   10                  15      


Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val 
            20                  25                  30          


Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys 
        35                  40                  45              


Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn 
    50                  55                  60                  


Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile 
65                  70                  75                  80  


Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro 
                85                  90                  95      


Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp 
            100                 105                 110         


Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys 
        115                 120                 125             


Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln 
    130                 135                 140                 


Ala Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe 
145                 150                 155                 160 


Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln 
                165                 170                 175     


Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala 
            180                 185                 190         


Thr Val Cys Gly Pro Leu Glu Val Leu Phe Gln Gly Pro Ser Ala Trp 
        195                 200                 205             


Ser His Pro Gln Phe Glu Lys Gly Gly Gly Ser Gly Gly Gly Ser Gly 
    210                 215                 220                 


Gly Ser Ala Trp Ser His Pro Gln Phe Glu Lys Gly Ser His His His 
225                 230                 235                 240 


His His His His His 
                245 


<210> 284
<211> 1310
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 284
Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser 
1               5                   10                  15      


Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val 
            20                  25                  30          


Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr 
        35                  40                  45              


Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe 
    50                  55                  60                  


Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr 
65                  70                  75                  80  


Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp 
                85                  90                  95      


Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val 
            100                 105                 110         


Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val 
        115                 120                 125             


Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val 
    130                 135                 140                 


Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe 
145                 150                 155                 160 


Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu 
                165                 170                 175     


Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His 
            180                 185                 190         


Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu 
        195                 200                 205             


Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln 
    210                 215                 220                 


Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser 
225                 230                 235                 240 


Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln 
                245                 250                 255     


Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp 
            260                 265                 270         


Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu 
        275                 280                 285             


Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg 
    290                 295                 300                 


Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu 
305                 310                 315                 320 


Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr 
                325                 330                 335     


Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val 
            340                 345                 350         


Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Cys 
        355                 360                 365             


Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser 
    370                 375                 380                 


Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr 
385                 390                 395                 400 


Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly 
                405                 410                 415     


Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly 
            420                 425                 430         


Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro 
        435                 440                 445             


Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro 
    450                 455                 460                 


Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr 
465                 470                 475                 480 


Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val 
                485                 490                 495     


Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro 
            500                 505                 510         


Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe 
        515                 520                 525             


Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe 
    530                 535                 540                 


Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala 
545                 550                 555                 560 


Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser 
                565                 570                 575     


Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln 
            580                 585                 590         


Val Ala Val Leu Tyr Gln Gly Val Asn Cys Thr Glu Val Pro Val Ala 
        595                 600                 605             


Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly 
    610                 615                 620                 


Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His 
625                 630                 635                 640 


Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys 
                645                 650                 655     


Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro Gly Ser Ala Ser Ser Val 
            660                 665                 670         


Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn 
        675                 680                 685             


Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr 
    690                 695                 700                 


Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser 
705                 710                 715                 720 


Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn 
                725                 730                 735     


Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu 
            740                 745                 750         


Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala 
        755                 760                 765             


Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly 
    770                 775                 780                 


Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg 
785                 790                 795                 800 


Ser Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala 
                805                 810                 815     


Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg 
            820                 825                 830         


Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro 
        835                 840                 845             


Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala 
    850                 855                 860                 


Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln 
865                 870                 875                 880 


Ile Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val 
                885                 890                 895     


Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe 
            900                 905                 910         


Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser 
        915                 920                 925             


Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu 
    930                 935                 940                 


Asn Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser 
945                 950                 955                 960 


Val Leu Asn Asp Ile Leu Ser Arg Leu Cys Pro Pro Glu Ala Glu Val 
                965                 970                 975     


Gln Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser Leu Gln Thr Tyr 
            980                 985                 990         


Val Thr Gln Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
        995                 1000                 1005             


Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1010                 1015                 1020             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1025                 1030                 1035             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1040                 1045                 1050             


Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1055                 1060                 1065             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1070                 1075                 1080             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1085                 1090                 1095             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1100                 1105                 1110             


Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro 
    1115                 1120                 1125             


Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Gly  Ser Gly Gly 
    1130                 1135                 1140             


Ser Gly  Asp Ile Ile Lys Leu  Leu Asn Glu Gln Val  Asn Lys Glu 
    1145                 1150                 1155             


Met Gln  Ser Ser Asn Leu Tyr  Met Ser Met Ser Ser  Trp Cys Tyr 
    1160                 1165                 1170             


Thr His  Ser Leu Asp Gly Ala  Gly Leu Phe Leu Phe  Asp His Ala 
    1175                 1180                 1185             


Ala Glu  Glu Tyr Glu His Ala  Lys Lys Leu Ile Ile  Phe Leu Asn 
    1190                 1195                 1200             


Glu Asn  Asn Val Pro Val Gln  Leu Thr Ser Ile Ser  Ala Pro Glu 
    1205                 1210                 1215             


His Lys  Phe Glu Gly Leu Thr  Gln Ile Phe Gln Lys  Ala Tyr Glu 
    1220                 1225                 1230             


His Glu  Gln His Ile Ser Glu  Ser Ile Asn Asn Ile  Val Asp His 
    1235                 1240                 1245             


Ala Ile  Lys Ser Lys Asp His  Ala Thr Phe Asn Phe  Leu Gln Trp 
    1250                 1255                 1260             


Tyr Val  Ala Glu Gln His Glu  Glu Glu Val Leu Phe  Lys Asp Ile 
    1265                 1270                 1275             


Leu Asp  Lys Ile Glu Leu Ile  Gly Asn Glu Asn His  Gly Leu Tyr 
    1280                 1285                 1290             


Leu Ala  Asp Gln Tyr Val Lys  Gly Ile Ala Lys Ser  Arg Lys Ser 
    1295                 1300                 1305             


Gly Ser  
    1310 


<210> 285
<211> 1318
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 285
Ser Ser Gln Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala 
1               5                   10                  15      


Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe 
            20                  25                  30          


Arg Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe 
        35                  40                  45              


Ser Asn Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly 
    50                  55                  60                  


Thr Lys Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr 
65                  70                  75                  80  


Phe Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly 
                85                  90                  95      


Thr Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala 
            100                 105                 110         


Thr Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro 
        115                 120                 125             


Phe Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser 
    130                 135                 140                 


Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val 
145                 150                 155                 160 


Ser Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys 
                165                 170                 175     


Asn Leu Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile 
            180                 185                 190         


Tyr Ser Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly 
        195                 200                 205             


Phe Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile 
    210                 215                 220                 


Thr Arg Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro 
225                 230                 235                 240 


Gly Asp Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val 
                245                 250                 255     


Gly Tyr Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly 
            260                 265                 270         


Thr Ile Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr 
        275                 280                 285             


Lys Cys Thr Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr 
    290                 295                 300                 


Ser Asn Phe Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn 
305                 310                 315                 320 


Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe 
                325                 330                 335     


Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala 
            340                 345                 350         


Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys 
        355                 360                 365             


Tyr Gly Val Cys Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val 
    370                 375                 380                 


Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala 
385                 390                 395                 400 


Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp 
                405                 410                 415     


Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser 
            420                 425                 430         


Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser 
        435                 440                 445             


Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala 
    450                 455                 460                 


Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro 
465                 470                 475                 480 


Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro 
                485                 490                 495     


Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr 
            500                 505                 510         


Val Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val 
        515                 520                 525             


Asn Phe Asn Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser 
    530                 535                 540                 


Asn Lys Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp 
545                 550                 555                 560 


Thr Thr Asp Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile 
                565                 570                 575     


Thr Pro Cys Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn 
            580                 585                 590         


Thr Ser Asn Gln Val Ala Val Leu Tyr Gln Gly Val Asn Cys Thr Glu 
        595                 600                 605             


Val Pro Val Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val 
    610                 615                 620                 


Tyr Ser Thr Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile 
625                 630                 635                 640 


Gly Ala Glu His Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly 
                645                 650                 655     


Ala Gly Ile Cys Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro Gly Ser 
            660                 665                 670         


Ala Ser Ser Val Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu 
        675                 680                 685             


Gly Ala Glu Asn Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro 
    690                 695                 700                 


Thr Asn Phe Thr Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met 
705                 710                 715                 720 


Thr Lys Thr Ser Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr 
                725                 730                 735     


Glu Cys Ser Asn Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu 
            740                 745                 750         


Asn Arg Ala Leu Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln 
        755                 760                 765             


Glu Val Phe Ala Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys 
    770                 775                 780                 


Asp Phe Gly Gly Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys 
785                 790                 795                 800 


Pro Ser Lys Arg Ser Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr 
                805                 810                 815     


Leu Ala Asp Ala Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp 
            820                 825                 830         


Ile Ala Ala Arg Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr 
        835                 840                 845             


Val Leu Pro Pro Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser 
    850                 855                 860                 


Ala Leu Leu Ala Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly 
865                 870                 875                 880 


Ala Ala Leu Gln Ile Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn 
                885                 890                 895     


Gly Ile Gly Val Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile 
            900                 905                 910         


Ala Asn Gln Phe Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser 
        915                 920                 925             


Ser Thr Ala Ser Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn 
    930                 935                 940                 


Ala Gln Ala Leu Asn Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly 
945                 950                 955                 960 


Ala Ile Ser Ser Val Leu Asn Asp Ile Leu Ser Arg Leu Cys Pro Pro 
                965                 970                 975     


Glu Ala Glu Val Gln Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser 
            980                 985                 990         


Leu Gln Thr Tyr Val Thr Gln Gln  Leu Ile Arg Ala Ala  Glu Ile Arg 
        995                 1000                 1005             


Ala Ser  Ala Asn Leu Ala Ala  Thr Lys Met Ser Glu  Cys Val Leu 
    1010                 1015                 1020             


Gly Gln  Ser Lys Arg Val Asp  Phe Cys Gly Lys Gly  Tyr His Leu 
    1025                 1030                 1035             


Met Ser  Phe Pro Gln Ser Ala  Pro His Gly Val Val  Phe Leu His 
    1040                 1045                 1050             


Val Thr  Tyr Val Pro Ala Gln  Glu Lys Asn Phe Thr  Thr Ala Pro 
    1055                 1060                 1065             


Ala Ile  Cys His Asp Gly Lys  Ala His Phe Pro Arg  Glu Gly Val 
    1070                 1075                 1080             


Phe Val  Ser Asn Gly Thr His  Trp Phe Val Thr Gln  Arg Asn Phe 
    1085                 1090                 1095             


Tyr Glu  Pro Gln Ile Ile Thr  Thr Asp Asn Thr Phe  Val Ser Gly 
    1100                 1105                 1110             


Asn Cys  Asp Val Val Ile Gly  Ile Val Asn Asn Thr  Val Tyr Asp 
    1115                 1120                 1125             


Pro Leu  Gln Ser Glu Leu Asp  Ser Ile Lys Glu Glu  Leu Asp Lys 
    1130                 1135                 1140             


Ile His  Lys Asn Gly Ser Gly  Gly Ser Gly Asp Ile  Ile Lys Leu 
    1145                 1150                 1155             


Leu Asn  Glu Gln Val Asn Lys  Glu Met Gln Ser Ser  Asn Leu Tyr 
    1160                 1165                 1170             


Met Ser  Met Ser Ser Trp Cys  Tyr Thr His Ser Leu  Asp Gly Ala 
    1175                 1180                 1185             


Gly Leu  Phe Leu Phe Asp His  Ala Ala Glu Glu Tyr  Glu His Ala 
    1190                 1195                 1200             


Lys Lys  Leu Ile Ile Phe Leu  Asn Glu Asn Asn Val  Pro Val Gln 
    1205                 1210                 1215             


Leu Thr  Ser Ile Ser Ala Pro  Glu His Lys Phe Glu  Gly Leu Thr 
    1220                 1225                 1230             


Gln Ile  Phe Gln Lys Ala Tyr  Glu His Glu Gln His  Ile Ser Glu 
    1235                 1240                 1245             


Ser Ile  Asn Asn Ile Val Asp  His Ala Ile Lys Ser  Lys Asp His 
    1250                 1255                 1260             


Ala Thr  Phe Asn Phe Leu Gln  Trp Tyr Val Ala Glu  Gln His Glu 
    1265                 1270                 1275             


Glu Glu  Val Leu Phe Lys Asp  Ile Leu Asp Lys Ile  Glu Leu Ile 
    1280                 1285                 1290             


Gly Asn  Glu Asn His Gly Leu  Tyr Leu Ala Asp Gln  Tyr Val Lys 
    1295                 1300                 1305             


Gly Ile  Ala Lys Ser Arg Lys  Ser Gly Ser 
    1310                 1315             


<210> 286
<211> 1332
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 286
Ser Ser Gln Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala 
1               5                   10                  15      


Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe 
            20                  25                  30          


Arg Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe 
        35                  40                  45              


Ser Asn Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly 
    50                  55                  60                  


Thr Lys Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr 
65                  70                  75                  80  


Phe Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly 
                85                  90                  95      


Thr Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala 
            100                 105                 110         


Thr Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro 
        115                 120                 125             


Phe Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser 
    130                 135                 140                 


Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val 
145                 150                 155                 160 


Ser Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys 
                165                 170                 175     


Asn Leu Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile 
            180                 185                 190         


Tyr Ser Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly 
        195                 200                 205             


Phe Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile 
    210                 215                 220                 


Thr Arg Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro 
225                 230                 235                 240 


Gly Asp Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val 
                245                 250                 255     


Gly Tyr Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly 
            260                 265                 270         


Thr Ile Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr 
        275                 280                 285             


Lys Cys Thr Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr 
    290                 295                 300                 


Ser Asn Phe Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn 
305                 310                 315                 320 


Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe 
                325                 330                 335     


Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala 
            340                 345                 350         


Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys 
        355                 360                 365             


Tyr Gly Val Cys Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val 
    370                 375                 380                 


Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala 
385                 390                 395                 400 


Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp 
                405                 410                 415     


Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser 
            420                 425                 430         


Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser 
        435                 440                 445             


Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala 
    450                 455                 460                 


Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro 
465                 470                 475                 480 


Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro 
                485                 490                 495     


Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr 
            500                 505                 510         


Val Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val 
        515                 520                 525             


Asn Phe Asn Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser 
    530                 535                 540                 


Asn Lys Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp 
545                 550                 555                 560 


Thr Thr Asp Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile 
                565                 570                 575     


Thr Pro Cys Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn 
            580                 585                 590         


Thr Ser Asn Gln Val Ala Val Leu Tyr Gln Gly Val Asn Cys Thr Glu 
        595                 600                 605             


Val Pro Val Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val 
    610                 615                 620                 


Tyr Ser Thr Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile 
625                 630                 635                 640 


Gly Ala Glu His Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly 
                645                 650                 655     


Ala Gly Ile Cys Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro Gly Ser 
            660                 665                 670         


Ala Ser Ser Val Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu 
        675                 680                 685             


Gly Ala Glu Asn Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro 
    690                 695                 700                 


Thr Asn Phe Thr Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met 
705                 710                 715                 720 


Thr Lys Thr Ser Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr 
                725                 730                 735     


Glu Cys Ser Asn Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu 
            740                 745                 750         


Asn Arg Ala Leu Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln 
        755                 760                 765             


Glu Val Phe Ala Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys 
    770                 775                 780                 


Asp Phe Gly Gly Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys 
785                 790                 795                 800 


Pro Ser Lys Arg Ser Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr 
                805                 810                 815     


Leu Ala Asp Ala Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp 
            820                 825                 830         


Ile Ala Ala Arg Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr 
        835                 840                 845             


Val Leu Pro Pro Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser 
    850                 855                 860                 


Ala Leu Leu Ala Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly 
865                 870                 875                 880 


Ala Ala Leu Gln Ile Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn 
                885                 890                 895     


Gly Ile Gly Val Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile 
            900                 905                 910         


Ala Asn Gln Phe Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser 
        915                 920                 925             


Ser Thr Ala Ser Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn 
    930                 935                 940                 


Ala Gln Ala Leu Asn Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly 
945                 950                 955                 960 


Ala Ile Ser Ser Val Leu Asn Asp Ile Leu Ser Arg Leu Cys Pro Pro 
                965                 970                 975     


Glu Ala Glu Val Gln Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser 
            980                 985                 990         


Leu Gln Thr Tyr Val Thr Gln Gln  Leu Ile Arg Ala Ala  Glu Ile Arg 
        995                 1000                 1005             


Ala Ser  Ala Asn Leu Ala Ala  Thr Lys Met Ser Glu  Cys Val Leu 
    1010                 1015                 1020             


Gly Gln  Ser Lys Arg Val Asp  Phe Cys Gly Lys Gly  Tyr His Leu 
    1025                 1030                 1035             


Met Ser  Phe Pro Gln Ser Ala  Pro His Gly Val Val  Phe Leu His 
    1040                 1045                 1050             


Val Thr  Tyr Val Pro Ala Gln  Glu Lys Asn Phe Thr  Thr Ala Pro 
    1055                 1060                 1065             


Ala Ile  Cys His Asp Gly Lys  Ala His Phe Pro Arg  Glu Gly Val 
    1070                 1075                 1080             


Phe Val  Ser Asn Gly Thr His  Trp Phe Val Thr Gln  Arg Asn Phe 
    1085                 1090                 1095             


Tyr Glu  Pro Gln Ile Ile Thr  Thr Asp Asn Thr Phe  Val Ser Gly 
    1100                 1105                 1110             


Asn Cys  Asp Val Val Ile Gly  Ile Val Asn Asn Thr  Val Tyr Asp 
    1115                 1120                 1125             


Pro Leu  Gln Ser Glu Leu Asp  Ser Ile Lys Glu Glu  Leu Asp Lys 
    1130                 1135                 1140             


Ile His  Lys Asn Leu Asp Ser  Ile Lys Glu Glu Leu  Asp Lys Ile 
    1145                 1150                 1155             


His Lys  Asn Gly Ser Gly Gly  Ser Gly Asp Ile Ile  Lys Leu Leu 
    1160                 1165                 1170             


Asn Glu  Gln Val Asn Lys Glu  Met Gln Ser Ser Asn  Leu Tyr Met 
    1175                 1180                 1185             


Ser Met  Ser Ser Trp Cys Tyr  Thr His Ser Leu Asp  Gly Ala Gly 
    1190                 1195                 1200             


Leu Phe  Leu Phe Asp His Ala  Ala Glu Glu Tyr Glu  His Ala Lys 
    1205                 1210                 1215             


Lys Leu  Ile Ile Phe Leu Asn  Glu Asn Asn Val Pro  Val Gln Leu 
    1220                 1225                 1230             


Thr Ser  Ile Ser Ala Pro Glu  His Lys Phe Glu Gly  Leu Thr Gln 
    1235                 1240                 1245             


Ile Phe  Gln Lys Ala Tyr Glu  His Glu Gln His Ile  Ser Glu Ser 
    1250                 1255                 1260             


Ile Asn  Asn Ile Val Asp His  Ala Ile Lys Ser Lys  Asp His Ala 
    1265                 1270                 1275             


Thr Phe  Asn Phe Leu Gln Trp  Tyr Val Ala Glu Gln  His Glu Glu 
    1280                 1285                 1290             


Glu Val  Leu Phe Lys Asp Ile  Leu Asp Lys Ile Glu  Leu Ile Gly 
    1295                 1300                 1305             


Asn Glu  Asn His Gly Leu Tyr  Leu Ala Asp Gln Tyr  Val Lys Gly 
    1310                 1315                 1320             


Ile Ala  Lys Ser Arg Lys Ser  Gly Ser 
    1325                 1330         


<210> 287
<211> 1310
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 287
Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser 
1               5                   10                  15      


Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val 
            20                  25                  30          


Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr 
        35                  40                  45              


Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe 
    50                  55                  60                  


Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr 
65                  70                  75                  80  


Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp 
                85                  90                  95      


Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val 
            100                 105                 110         


Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val 
        115                 120                 125             


Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val 
    130                 135                 140                 


Tyr Ser Ser Ala Asn Gln Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe 
145                 150                 155                 160 


Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu 
                165                 170                 175     


Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His 
            180                 185                 190         


Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu 
        195                 200                 205             


Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln 
    210                 215                 220                 


Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser 
225                 230                 235                 240 


Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln 
                245                 250                 255     


Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp 
            260                 265                 270         


Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu 
        275                 280                 285             


Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg 
    290                 295                 300                 


Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu 
305                 310                 315                 320 


Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr 
                325                 330                 335     


Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val 
            340                 345                 350         


Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser 
        355                 360                 365             


Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser 
    370                 375                 380                 


Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr 
385                 390                 395                 400 


Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly 
                405                 410                 415     


Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly 
            420                 425                 430         


Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro 
        435                 440                 445             


Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro 
    450                 455                 460                 


Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr 
465                 470                 475                 480 


Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val 
                485                 490                 495     


Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro 
            500                 505                 510         


Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe 
        515                 520                 525             


Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe 
    530                 535                 540                 


Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala 
545                 550                 555                 560 


Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser 
                565                 570                 575     


Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln 
            580                 585                 590         


Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala 
        595                 600                 605             


Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly 
    610                 615                 620                 


Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His 
625                 630                 635                 640 


Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys 
                645                 650                 655     


Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro Gly Ser Ala Ser Ser Val 
            660                 665                 670         


Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn 
        675                 680                 685             


Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr 
    690                 695                 700                 


Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser 
705                 710                 715                 720 


Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn 
                725                 730                 735     


Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu 
            740                 745                 750         


Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala 
        755                 760                 765             


Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly 
    770                 775                 780                 


Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg 
785                 790                 795                 800 


Ser Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala 
                805                 810                 815     


Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg 
            820                 825                 830         


Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro 
        835                 840                 845             


Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala 
    850                 855                 860                 


Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln 
865                 870                 875                 880 


Ile Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val 
                885                 890                 895     


Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe 
            900                 905                 910         


Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser 
        915                 920                 925             


Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu 
    930                 935                 940                 


Asn Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser 
945                 950                 955                 960 


Val Leu Asn Asp Ile Leu Ser Arg Leu Asp Pro Pro Glu Ala Glu Val 
                965                 970                 975     


Gln Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser Leu Gln Thr Tyr 
            980                 985                 990         


Val Thr Gln Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
        995                 1000                 1005             


Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1010                 1015                 1020             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1025                 1030                 1035             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1040                 1045                 1050             


Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1055                 1060                 1065             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1070                 1075                 1080             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1085                 1090                 1095             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1100                 1105                 1110             


Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro 
    1115                 1120                 1125             


Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Gly  Ser Gly Gly 
    1130                 1135                 1140             


Ser Gly  Asp Ile Ile Lys Leu  Leu Asn Glu Gln Val  Asn Lys Glu 
    1145                 1150                 1155             


Met Gln  Ser Ser Asn Leu Tyr  Met Ser Met Ser Ser  Trp Cys Tyr 
    1160                 1165                 1170             


Thr His  Ser Leu Asp Gly Ala  Gly Leu Phe Leu Phe  Asp His Ala 
    1175                 1180                 1185             


Ala Glu  Glu Tyr Glu His Ala  Lys Lys Leu Ile Ile  Phe Leu Asn 
    1190                 1195                 1200             


Glu Asn  Asn Val Pro Val Gln  Leu Thr Ser Ile Ser  Ala Pro Glu 
    1205                 1210                 1215             


His Lys  Phe Glu Gly Leu Thr  Gln Ile Phe Gln Lys  Ala Tyr Glu 
    1220                 1225                 1230             


His Glu  Gln His Ile Ser Glu  Ser Ile Asn Asn Ile  Val Asp His 
    1235                 1240                 1245             


Ala Ile  Lys Ser Lys Asp His  Ala Thr Phe Asn Phe  Leu Gln Trp 
    1250                 1255                 1260             


Tyr Val  Ala Glu Gln His Glu  Glu Glu Val Leu Phe  Lys Asp Ile 
    1265                 1270                 1275             


Leu Asp  Lys Ile Glu Leu Ile  Gly Asn Glu Asn His  Gly Leu Tyr 
    1280                 1285                 1290             


Leu Ala  Asp Gln Tyr Val Lys  Gly Ile Ala Lys Ser  Arg Lys Ser 
    1295                 1300                 1305             


Gly Ser  
    1310 


<210> 288
<211> 1310
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 288
Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser 
1               5                   10                  15      


Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val 
            20                  25                  30          


Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr 
        35                  40                  45              


Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe 
    50                  55                  60                  


Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr 
65                  70                  75                  80  


Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp 
                85                  90                  95      


Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val 
            100                 105                 110         


Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val 
        115                 120                 125             


Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val 
    130                 135                 140                 


Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe 
145                 150                 155                 160 


Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu 
                165                 170                 175     


Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His 
            180                 185                 190         


Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu 
        195                 200                 205             


Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Gln Ile Thr Arg Phe Gln 
    210                 215                 220                 


Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser 
225                 230                 235                 240 


Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln 
                245                 250                 255     


Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp 
            260                 265                 270         


Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu 
        275                 280                 285             


Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg 
    290                 295                 300                 


Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu 
305                 310                 315                 320 


Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr 
                325                 330                 335     


Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val 
            340                 345                 350         


Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser 
        355                 360                 365             


Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser 
    370                 375                 380                 


Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr 
385                 390                 395                 400 


Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly 
                405                 410                 415     


Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly 
            420                 425                 430         


Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro 
        435                 440                 445             


Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro 
    450                 455                 460                 


Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr 
465                 470                 475                 480 


Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val 
                485                 490                 495     


Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro 
            500                 505                 510         


Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe 
        515                 520                 525             


Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe 
    530                 535                 540                 


Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala 
545                 550                 555                 560 


Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser 
                565                 570                 575     


Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln 
            580                 585                 590         


Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala 
        595                 600                 605             


Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly 
    610                 615                 620                 


Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His 
625                 630                 635                 640 


Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys 
                645                 650                 655     


Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro Gly Ser Ala Ser Ser Val 
            660                 665                 670         


Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn 
        675                 680                 685             


Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr 
    690                 695                 700                 


Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser 
705                 710                 715                 720 


Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn 
                725                 730                 735     


Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu 
            740                 745                 750         


Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala 
        755                 760                 765             


Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly 
    770                 775                 780                 


Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg 
785                 790                 795                 800 


Ser Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala 
                805                 810                 815     


Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg 
            820                 825                 830         


Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro 
        835                 840                 845             


Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala 
    850                 855                 860                 


Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln 
865                 870                 875                 880 


Ile Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val 
                885                 890                 895     


Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe 
            900                 905                 910         


Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser 
        915                 920                 925             


Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu 
    930                 935                 940                 


Asn Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser 
945                 950                 955                 960 


Val Leu Asn Asp Ile Leu Ser Arg Leu Asp Pro Pro Glu Ala Glu Val 
                965                 970                 975     


Gln Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser Leu Gln Thr Tyr 
            980                 985                 990         


Val Thr Gln Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
        995                 1000                 1005             


Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1010                 1015                 1020             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1025                 1030                 1035             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1040                 1045                 1050             


Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1055                 1060                 1065             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1070                 1075                 1080             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1085                 1090                 1095             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1100                 1105                 1110             


Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro 
    1115                 1120                 1125             


Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Gly  Ser Gly Gly 
    1130                 1135                 1140             


Ser Gly  Asp Ile Ile Lys Leu  Leu Asn Glu Gln Val  Asn Lys Glu 
    1145                 1150                 1155             


Met Gln  Ser Ser Asn Leu Tyr  Met Ser Met Ser Ser  Trp Cys Tyr 
    1160                 1165                 1170             


Thr His  Ser Leu Asp Gly Ala  Gly Leu Phe Leu Phe  Asp His Ala 
    1175                 1180                 1185             


Ala Glu  Glu Tyr Glu His Ala  Lys Lys Leu Ile Ile  Phe Leu Asn 
    1190                 1195                 1200             


Glu Asn  Asn Val Pro Val Gln  Leu Thr Ser Ile Ser  Ala Pro Glu 
    1205                 1210                 1215             


His Lys  Phe Glu Gly Leu Thr  Gln Ile Phe Gln Lys  Ala Tyr Glu 
    1220                 1225                 1230             


His Glu  Gln His Ile Ser Glu  Ser Ile Asn Asn Ile  Val Asp His 
    1235                 1240                 1245             


Ala Ile  Lys Ser Lys Asp His  Ala Thr Phe Asn Phe  Leu Gln Trp 
    1250                 1255                 1260             


Tyr Val  Ala Glu Gln His Glu  Glu Glu Val Leu Phe  Lys Asp Ile 
    1265                 1270                 1275             


Leu Asp  Lys Ile Glu Leu Ile  Gly Asn Glu Asn His  Gly Leu Tyr 
    1280                 1285                 1290             


Leu Ala  Asp Gln Tyr Val Lys  Gly Ile Ala Lys Ser  Arg Lys Ser 
    1295                 1300                 1305             


Gly Ser  
    1310 


<210> 289
<211> 1318
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 289
Ser Ser Gln Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala 
1               5                   10                  15      


Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe 
            20                  25                  30          


Arg Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe 
        35                  40                  45              


Ser Asn Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly 
    50                  55                  60                  


Thr Lys Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr 
65                  70                  75                  80  


Phe Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly 
                85                  90                  95      


Thr Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala 
            100                 105                 110         


Thr Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro 
        115                 120                 125             


Phe Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser 
    130                 135                 140                 


Glu Phe Arg Val Tyr Ser Ser Ala Asn Gln Cys Thr Phe Glu Tyr Val 
145                 150                 155                 160 


Ser Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys 
                165                 170                 175     


Asn Leu Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile 
            180                 185                 190         


Tyr Ser Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly 
        195                 200                 205             


Phe Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile 
    210                 215                 220                 


Thr Arg Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro 
225                 230                 235                 240 


Gly Asp Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val 
                245                 250                 255     


Gly Tyr Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly 
            260                 265                 270         


Thr Ile Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr 
        275                 280                 285             


Lys Cys Thr Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr 
    290                 295                 300                 


Ser Asn Phe Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn 
305                 310                 315                 320 


Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe 
                325                 330                 335     


Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala 
            340                 345                 350         


Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys 
        355                 360                 365             


Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val 
    370                 375                 380                 


Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala 
385                 390                 395                 400 


Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp 
                405                 410                 415     


Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser 
            420                 425                 430         


Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser 
        435                 440                 445             


Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala 
    450                 455                 460                 


Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro 
465                 470                 475                 480 


Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro 
                485                 490                 495     


Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr 
            500                 505                 510         


Val Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val 
        515                 520                 525             


Asn Phe Asn Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser 
    530                 535                 540                 


Asn Lys Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp 
545                 550                 555                 560 


Thr Thr Asp Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile 
                565                 570                 575     


Thr Pro Cys Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn 
            580                 585                 590         


Thr Ser Asn Gln Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu 
        595                 600                 605             


Val Pro Val Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val 
    610                 615                 620                 


Tyr Ser Thr Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile 
625                 630                 635                 640 


Gly Ala Glu His Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly 
                645                 650                 655     


Ala Gly Ile Cys Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro Gly Ser 
            660                 665                 670         


Ala Ser Ser Val Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu 
        675                 680                 685             


Gly Ala Glu Asn Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro 
    690                 695                 700                 


Thr Asn Phe Thr Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met 
705                 710                 715                 720 


Thr Lys Thr Ser Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr 
                725                 730                 735     


Glu Cys Ser Asn Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu 
            740                 745                 750         


Asn Arg Ala Leu Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln 
        755                 760                 765             


Glu Val Phe Ala Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys 
    770                 775                 780                 


Asp Phe Gly Gly Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys 
785                 790                 795                 800 


Pro Ser Lys Arg Ser Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr 
                805                 810                 815     


Leu Ala Asp Ala Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp 
            820                 825                 830         


Ile Ala Ala Arg Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr 
        835                 840                 845             


Val Leu Pro Pro Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser 
    850                 855                 860                 


Ala Leu Leu Ala Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly 
865                 870                 875                 880 


Ala Ala Leu Gln Ile Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn 
                885                 890                 895     


Gly Ile Gly Val Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile 
            900                 905                 910         


Ala Asn Gln Phe Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser 
        915                 920                 925             


Ser Thr Ala Ser Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn 
    930                 935                 940                 


Ala Gln Ala Leu Asn Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly 
945                 950                 955                 960 


Ala Ile Ser Ser Val Leu Asn Asp Ile Leu Ser Arg Leu Asp Pro Pro 
                965                 970                 975     


Glu Ala Glu Val Gln Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser 
            980                 985                 990         


Leu Gln Thr Tyr Val Thr Gln Gln  Leu Ile Arg Ala Ala  Glu Ile Arg 
        995                 1000                 1005             


Ala Ser  Ala Asn Leu Ala Ala  Thr Lys Met Ser Glu  Cys Val Leu 
    1010                 1015                 1020             


Gly Gln  Ser Lys Arg Val Asp  Phe Cys Gly Lys Gly  Tyr His Leu 
    1025                 1030                 1035             


Met Ser  Phe Pro Gln Ser Ala  Pro His Gly Val Val  Phe Leu His 
    1040                 1045                 1050             


Val Thr  Tyr Val Pro Ala Gln  Glu Lys Asn Phe Thr  Thr Ala Pro 
    1055                 1060                 1065             


Ala Ile  Cys His Asp Gly Lys  Ala His Phe Pro Arg  Glu Gly Val 
    1070                 1075                 1080             


Phe Val  Ser Asn Gly Thr His  Trp Phe Val Thr Gln  Arg Asn Phe 
    1085                 1090                 1095             


Tyr Glu  Pro Gln Ile Ile Thr  Thr Asp Asn Thr Phe  Val Ser Gly 
    1100                 1105                 1110             


Asn Cys  Asp Val Val Ile Gly  Ile Val Asn Asn Thr  Val Tyr Asp 
    1115                 1120                 1125             


Pro Leu  Gln Ser Glu Leu Asp  Ser Ile Lys Glu Glu  Leu Asp Lys 
    1130                 1135                 1140             


Ile His  Lys Asn Gly Ser Gly  Gly Ser Gly Asp Ile  Ile Lys Leu 
    1145                 1150                 1155             


Leu Asn  Glu Gln Val Asn Lys  Glu Met Gln Ser Ser  Asn Leu Tyr 
    1160                 1165                 1170             


Met Ser  Met Ser Ser Trp Cys  Tyr Thr His Ser Leu  Asp Gly Ala 
    1175                 1180                 1185             


Gly Leu  Phe Leu Phe Asp His  Ala Ala Glu Glu Tyr  Glu His Ala 
    1190                 1195                 1200             


Lys Lys  Leu Ile Ile Phe Leu  Asn Glu Asn Asn Val  Pro Val Gln 
    1205                 1210                 1215             


Leu Thr  Ser Ile Ser Ala Pro  Glu His Lys Phe Glu  Gly Leu Thr 
    1220                 1225                 1230             


Gln Ile  Phe Gln Lys Ala Tyr  Glu His Glu Gln His  Ile Ser Glu 
    1235                 1240                 1245             


Ser Ile  Asn Asn Ile Val Asp  His Ala Ile Lys Ser  Lys Asp His 
    1250                 1255                 1260             


Ala Thr  Phe Asn Phe Leu Gln  Trp Tyr Val Ala Glu  Gln His Glu 
    1265                 1270                 1275             


Glu Glu  Val Leu Phe Lys Asp  Ile Leu Asp Lys Ile  Glu Leu Ile 
    1280                 1285                 1290             


Gly Asn  Glu Asn His Gly Leu  Tyr Leu Ala Asp Gln  Tyr Val Lys 
    1295                 1300                 1305             


Gly Ile  Ala Lys Ser Arg Lys  Ser Gly Ser 
    1310                 1315             


<210> 290
<211> 1318
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 290
Ser Ser Gln Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala 
1               5                   10                  15      


Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe 
            20                  25                  30          


Arg Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe 
        35                  40                  45              


Ser Asn Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly 
    50                  55                  60                  


Thr Lys Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr 
65                  70                  75                  80  


Phe Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly 
                85                  90                  95      


Thr Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala 
            100                 105                 110         


Thr Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro 
        115                 120                 125             


Phe Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser 
    130                 135                 140                 


Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val 
145                 150                 155                 160 


Ser Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys 
                165                 170                 175     


Asn Leu Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile 
            180                 185                 190         


Tyr Ser Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly 
        195                 200                 205             


Phe Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Gln Ile 
    210                 215                 220                 


Thr Arg Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro 
225                 230                 235                 240 


Gly Asp Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val 
                245                 250                 255     


Gly Tyr Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly 
            260                 265                 270         


Thr Ile Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr 
        275                 280                 285             


Lys Cys Thr Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr 
    290                 295                 300                 


Ser Asn Phe Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn 
305                 310                 315                 320 


Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe 
                325                 330                 335     


Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala 
            340                 345                 350         


Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys 
        355                 360                 365             


Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val 
    370                 375                 380                 


Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala 
385                 390                 395                 400 


Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp 
                405                 410                 415     


Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser 
            420                 425                 430         


Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser 
        435                 440                 445             


Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala 
    450                 455                 460                 


Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro 
465                 470                 475                 480 


Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro 
                485                 490                 495     


Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr 
            500                 505                 510         


Val Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val 
        515                 520                 525             


Asn Phe Asn Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser 
    530                 535                 540                 


Asn Lys Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp 
545                 550                 555                 560 


Thr Thr Asp Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile 
                565                 570                 575     


Thr Pro Cys Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn 
            580                 585                 590         


Thr Ser Asn Gln Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu 
        595                 600                 605             


Val Pro Val Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val 
    610                 615                 620                 


Tyr Ser Thr Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile 
625                 630                 635                 640 


Gly Ala Glu His Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly 
                645                 650                 655     


Ala Gly Ile Cys Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro Gly Ser 
            660                 665                 670         


Ala Ser Ser Val Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu 
        675                 680                 685             


Gly Ala Glu Asn Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro 
    690                 695                 700                 


Thr Asn Phe Thr Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met 
705                 710                 715                 720 


Thr Lys Thr Ser Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr 
                725                 730                 735     


Glu Cys Ser Asn Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu 
            740                 745                 750         


Asn Arg Ala Leu Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln 
        755                 760                 765             


Glu Val Phe Ala Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys 
    770                 775                 780                 


Asp Phe Gly Gly Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys 
785                 790                 795                 800 


Pro Ser Lys Arg Ser Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr 
                805                 810                 815     


Leu Ala Asp Ala Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp 
            820                 825                 830         


Ile Ala Ala Arg Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr 
        835                 840                 845             


Val Leu Pro Pro Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser 
    850                 855                 860                 


Ala Leu Leu Ala Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly 
865                 870                 875                 880 


Ala Ala Leu Gln Ile Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn 
                885                 890                 895     


Gly Ile Gly Val Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile 
            900                 905                 910         


Ala Asn Gln Phe Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser 
        915                 920                 925             


Ser Thr Ala Ser Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn 
    930                 935                 940                 


Ala Gln Ala Leu Asn Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly 
945                 950                 955                 960 


Ala Ile Ser Ser Val Leu Asn Asp Ile Leu Ser Arg Leu Asp Pro Pro 
                965                 970                 975     


Glu Ala Glu Val Gln Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser 
            980                 985                 990         


Leu Gln Thr Tyr Val Thr Gln Gln  Leu Ile Arg Ala Ala  Glu Ile Arg 
        995                 1000                 1005             


Ala Ser  Ala Asn Leu Ala Ala  Thr Lys Met Ser Glu  Cys Val Leu 
    1010                 1015                 1020             


Gly Gln  Ser Lys Arg Val Asp  Phe Cys Gly Lys Gly  Tyr His Leu 
    1025                 1030                 1035             


Met Ser  Phe Pro Gln Ser Ala  Pro His Gly Val Val  Phe Leu His 
    1040                 1045                 1050             


Val Thr  Tyr Val Pro Ala Gln  Glu Lys Asn Phe Thr  Thr Ala Pro 
    1055                 1060                 1065             


Ala Ile  Cys His Asp Gly Lys  Ala His Phe Pro Arg  Glu Gly Val 
    1070                 1075                 1080             


Phe Val  Ser Asn Gly Thr His  Trp Phe Val Thr Gln  Arg Asn Phe 
    1085                 1090                 1095             


Tyr Glu  Pro Gln Ile Ile Thr  Thr Asp Asn Thr Phe  Val Ser Gly 
    1100                 1105                 1110             


Asn Cys  Asp Val Val Ile Gly  Ile Val Asn Asn Thr  Val Tyr Asp 
    1115                 1120                 1125             


Pro Leu  Gln Ser Glu Leu Asp  Ser Ile Lys Glu Glu  Leu Asp Lys 
    1130                 1135                 1140             


Ile His  Lys Asn Gly Ser Gly  Gly Ser Gly Asp Ile  Ile Lys Leu 
    1145                 1150                 1155             


Leu Asn  Glu Gln Val Asn Lys  Glu Met Gln Ser Ser  Asn Leu Tyr 
    1160                 1165                 1170             


Met Ser  Met Ser Ser Trp Cys  Tyr Thr His Ser Leu  Asp Gly Ala 
    1175                 1180                 1185             


Gly Leu  Phe Leu Phe Asp His  Ala Ala Glu Glu Tyr  Glu His Ala 
    1190                 1195                 1200             


Lys Lys  Leu Ile Ile Phe Leu  Asn Glu Asn Asn Val  Pro Val Gln 
    1205                 1210                 1215             


Leu Thr  Ser Ile Ser Ala Pro  Glu His Lys Phe Glu  Gly Leu Thr 
    1220                 1225                 1230             


Gln Ile  Phe Gln Lys Ala Tyr  Glu His Glu Gln His  Ile Ser Glu 
    1235                 1240                 1245             


Ser Ile  Asn Asn Ile Val Asp  His Ala Ile Lys Ser  Lys Asp His 
    1250                 1255                 1260             


Ala Thr  Phe Asn Phe Leu Gln  Trp Tyr Val Ala Glu  Gln His Glu 
    1265                 1270                 1275             


Glu Glu  Val Leu Phe Lys Asp  Ile Leu Asp Lys Ile  Glu Leu Ile 
    1280                 1285                 1290             


Gly Asn  Glu Asn His Gly Leu  Tyr Leu Ala Asp Gln  Tyr Val Lys 
    1295                 1300                 1305             


Gly Ile  Ala Lys Ser Arg Lys  Ser Gly Ser 
    1310                 1315             


<210> 291
<211> 1318
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 291
Ser Ser Gln Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala 
1               5                   10                  15      


Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe 
            20                  25                  30          


Arg Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe 
        35                  40                  45              


Ser Asn Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly 
    50                  55                  60                  


Thr Lys Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr 
65                  70                  75                  80  


Phe Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly 
                85                  90                  95      


Thr Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala 
            100                 105                 110         


Thr Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro 
        115                 120                 125             


Phe Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser 
    130                 135                 140                 


Glu Phe Arg Val Tyr Ser Ser Ala Asn Gln Cys Thr Phe Glu Tyr Val 
145                 150                 155                 160 


Ser Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys 
                165                 170                 175     


Asn Leu Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile 
            180                 185                 190         


Tyr Ser Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly 
        195                 200                 205             


Phe Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile 
    210                 215                 220                 


Thr Arg Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro 
225                 230                 235                 240 


Gly Asp Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val 
                245                 250                 255     


Gly Tyr Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly 
            260                 265                 270         


Thr Ile Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr 
        275                 280                 285             


Lys Cys Thr Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr 
    290                 295                 300                 


Ser Asn Phe Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn 
305                 310                 315                 320 


Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe 
                325                 330                 335     


Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala 
            340                 345                 350         


Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys 
        355                 360                 365             


Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val 
    370                 375                 380                 


Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala 
385                 390                 395                 400 


Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp 
                405                 410                 415     


Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser 
            420                 425                 430         


Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser 
        435                 440                 445             


Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala 
    450                 455                 460                 


Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro 
465                 470                 475                 480 


Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro 
                485                 490                 495     


Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr 
            500                 505                 510         


Val Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val 
        515                 520                 525             


Asn Phe Asn Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser 
    530                 535                 540                 


Asn Lys Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp 
545                 550                 555                 560 


Thr Thr Asp Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile 
                565                 570                 575     


Thr Pro Cys Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn 
            580                 585                 590         


Thr Ser Asn Gln Val Ala Val Leu Tyr Gln Gly Val Asn Cys Thr Glu 
        595                 600                 605             


Val Pro Val Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val 
    610                 615                 620                 


Tyr Ser Thr Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile 
625                 630                 635                 640 


Gly Ala Glu His Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly 
                645                 650                 655     


Ala Gly Ile Cys Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro Gly Ser 
            660                 665                 670         


Ala Ser Ser Val Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu 
        675                 680                 685             


Gly Ala Glu Asn Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro 
    690                 695                 700                 


Thr Asn Phe Thr Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met 
705                 710                 715                 720 


Thr Lys Thr Ser Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr 
                725                 730                 735     


Glu Cys Ser Asn Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu 
            740                 745                 750         


Asn Arg Ala Leu Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln 
        755                 760                 765             


Glu Val Phe Ala Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys 
    770                 775                 780                 


Asp Phe Gly Gly Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys 
785                 790                 795                 800 


Pro Ser Lys Arg Ser Pro Ile Glu Asp Leu Leu Phe Asn Lys Val Thr 
                805                 810                 815     


Leu Ala Asp Ala Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp 
            820                 825                 830         


Ile Ala Ala Arg Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr 
        835                 840                 845             


Val Leu Pro Pro Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser 
    850                 855                 860                 


Ala Leu Leu Ala Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly 
865                 870                 875                 880 


Pro Ala Leu Gln Ile Pro Phe Pro Met Gln Met Ala Tyr Arg Phe Asn 
                885                 890                 895     


Gly Ile Gly Val Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile 
            900                 905                 910         


Ala Asn Gln Phe Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser 
        915                 920                 925             


Ser Thr Pro Ser Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn 
    930                 935                 940                 


Ala Gln Ala Leu Asn Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly 
945                 950                 955                 960 


Ala Ile Ser Ser Val Leu Asn Asp Ile Leu Ser Arg Leu Asp Pro Pro 
                965                 970                 975     


Glu Ala Glu Val Gln Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser 
            980                 985                 990         


Leu Gln Thr Tyr Val Thr Gln Gln  Leu Ile Arg Ala Ala  Glu Ile Arg 
        995                 1000                 1005             


Ala Ser  Ala Asn Leu Ala Ala  Thr Lys Met Ser Glu  Cys Val Leu 
    1010                 1015                 1020             


Gly Gln  Ser Lys Arg Val Asp  Phe Cys Gly Lys Gly  Tyr His Leu 
    1025                 1030                 1035             


Met Ser  Phe Pro Gln Ser Ala  Pro His Gly Val Val  Phe Leu His 
    1040                 1045                 1050             


Val Thr  Tyr Val Pro Ala Gln  Glu Lys Asn Phe Thr  Thr Ala Pro 
    1055                 1060                 1065             


Ala Ile  Cys His Asp Gly Lys  Ala His Phe Pro Arg  Glu Gly Val 
    1070                 1075                 1080             


Phe Val  Ser Asn Gly Thr His  Trp Phe Val Thr Gln  Arg Asn Phe 
    1085                 1090                 1095             


Tyr Glu  Pro Gln Ile Ile Thr  Thr Asp Asn Thr Phe  Val Ser Gly 
    1100                 1105                 1110             


Asn Cys  Asp Val Val Ile Gly  Ile Val Asn Asn Thr  Val Tyr Asp 
    1115                 1120                 1125             


Pro Leu  Gln Ser Glu Leu Asp  Ser Ile Lys Glu Glu  Leu Asp Lys 
    1130                 1135                 1140             


Ile His  Lys Asn Gly Ser Gly  Gly Ser Gly Asp Ile  Ile Lys Leu 
    1145                 1150                 1155             


Leu Asn  Glu Gln Val Asn Lys  Glu Met Gln Ser Ser  Asn Leu Tyr 
    1160                 1165                 1170             


Met Ser  Met Ser Ser Trp Cys  Tyr Thr His Ser Leu  Asp Gly Ala 
    1175                 1180                 1185             


Gly Leu  Phe Leu Phe Asp His  Ala Ala Glu Glu Tyr  Glu His Ala 
    1190                 1195                 1200             


Lys Lys  Leu Ile Ile Phe Leu  Asn Glu Asn Asn Val  Pro Val Gln 
    1205                 1210                 1215             


Leu Thr  Ser Ile Ser Ala Pro  Glu His Lys Phe Glu  Gly Leu Thr 
    1220                 1225                 1230             


Gln Ile  Phe Gln Lys Ala Tyr  Glu His Glu Gln His  Ile Ser Glu 
    1235                 1240                 1245             


Ser Ile  Asn Asn Ile Val Asp  His Ala Ile Lys Ser  Lys Asp His 
    1250                 1255                 1260             


Ala Thr  Phe Asn Phe Leu Gln  Trp Tyr Val Ala Glu  Gln His Glu 
    1265                 1270                 1275             


Glu Glu  Val Leu Phe Lys Asp  Ile Leu Asp Lys Ile  Glu Leu Ile 
    1280                 1285                 1290             


Gly Asn  Glu Asn His Gly Leu  Tyr Leu Ala Asp Gln  Tyr Val Lys 
    1295                 1300                 1305             


Gly Ile  Ala Lys Ser Arg Lys  Ser Gly Ser 
    1310                 1315             


<210> 292
<211> 1318
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 292
Ser Ser Gln Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala 
1               5                   10                  15      


Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe 
            20                  25                  30          


Arg Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe 
        35                  40                  45              


Ser Asn Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly 
    50                  55                  60                  


Thr Lys Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr 
65                  70                  75                  80  


Phe Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly 
                85                  90                  95      


Thr Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala 
            100                 105                 110         


Thr Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro 
        115                 120                 125             


Phe Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser 
    130                 135                 140                 


Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val 
145                 150                 155                 160 


Ser Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys 
                165                 170                 175     


Asn Leu Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile 
            180                 185                 190         


Tyr Ser Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly 
        195                 200                 205             


Phe Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Gln Ile 
    210                 215                 220                 


Thr Arg Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro 
225                 230                 235                 240 


Gly Asp Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val 
                245                 250                 255     


Gly Tyr Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly 
            260                 265                 270         


Thr Ile Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr 
        275                 280                 285             


Lys Cys Thr Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr 
    290                 295                 300                 


Ser Asn Phe Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn 
305                 310                 315                 320 


Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe 
                325                 330                 335     


Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala 
            340                 345                 350         


Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys 
        355                 360                 365             


Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val 
    370                 375                 380                 


Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala 
385                 390                 395                 400 


Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp 
                405                 410                 415     


Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser 
            420                 425                 430         


Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser 
        435                 440                 445             


Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala 
    450                 455                 460                 


Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro 
465                 470                 475                 480 


Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro 
                485                 490                 495     


Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr 
            500                 505                 510         


Val Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val 
        515                 520                 525             


Asn Phe Asn Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser 
    530                 535                 540                 


Asn Lys Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp 
545                 550                 555                 560 


Thr Thr Asp Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile 
                565                 570                 575     


Thr Pro Cys Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn 
            580                 585                 590         


Thr Ser Asn Gln Val Ala Val Leu Tyr Gln Gly Val Asn Cys Thr Glu 
        595                 600                 605             


Val Pro Val Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val 
    610                 615                 620                 


Tyr Ser Thr Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile 
625                 630                 635                 640 


Gly Ala Glu His Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly 
                645                 650                 655     


Ala Gly Ile Cys Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro Gly Ser 
            660                 665                 670         


Ala Ser Ser Val Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu 
        675                 680                 685             


Gly Ala Glu Asn Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro 
    690                 695                 700                 


Thr Asn Phe Thr Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met 
705                 710                 715                 720 


Thr Lys Thr Ser Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr 
                725                 730                 735     


Glu Cys Ser Asn Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu 
            740                 745                 750         


Asn Arg Ala Leu Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln 
        755                 760                 765             


Glu Val Phe Ala Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys 
    770                 775                 780                 


Asp Phe Gly Gly Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys 
785                 790                 795                 800 


Pro Ser Lys Arg Ser Pro Ile Glu Asp Leu Leu Phe Asn Lys Val Thr 
                805                 810                 815     


Leu Ala Asp Ala Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp 
            820                 825                 830         


Ile Ala Ala Arg Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr 
        835                 840                 845             


Val Leu Pro Pro Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser 
    850                 855                 860                 


Ala Leu Leu Ala Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly 
865                 870                 875                 880 


Pro Ala Leu Gln Ile Pro Phe Pro Met Gln Met Ala Tyr Arg Phe Asn 
                885                 890                 895     


Gly Ile Gly Val Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile 
            900                 905                 910         


Ala Asn Gln Phe Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser 
        915                 920                 925             


Ser Thr Pro Ser Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn 
    930                 935                 940                 


Ala Gln Ala Leu Asn Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly 
945                 950                 955                 960 


Ala Ile Ser Ser Val Leu Asn Asp Ile Leu Ser Arg Leu Asp Pro Pro 
                965                 970                 975     


Glu Ala Glu Val Gln Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser 
            980                 985                 990         


Leu Gln Thr Tyr Val Thr Gln Gln  Leu Ile Arg Ala Ala  Glu Ile Arg 
        995                 1000                 1005             


Ala Ser  Ala Asn Leu Ala Ala  Thr Lys Met Ser Glu  Cys Val Leu 
    1010                 1015                 1020             


Gly Gln  Ser Lys Arg Val Asp  Phe Cys Gly Lys Gly  Tyr His Leu 
    1025                 1030                 1035             


Met Ser  Phe Pro Gln Ser Ala  Pro His Gly Val Val  Phe Leu His 
    1040                 1045                 1050             


Val Thr  Tyr Val Pro Ala Gln  Glu Lys Asn Phe Thr  Thr Ala Pro 
    1055                 1060                 1065             


Ala Ile  Cys His Asp Gly Lys  Ala His Phe Pro Arg  Glu Gly Val 
    1070                 1075                 1080             


Phe Val  Ser Asn Gly Thr His  Trp Phe Val Thr Gln  Arg Asn Phe 
    1085                 1090                 1095             


Tyr Glu  Pro Gln Ile Ile Thr  Thr Asp Asn Thr Phe  Val Ser Gly 
    1100                 1105                 1110             


Asn Cys  Asp Val Val Ile Gly  Ile Val Asn Asn Thr  Val Tyr Asp 
    1115                 1120                 1125             


Pro Leu  Gln Ser Glu Leu Asp  Ser Ile Lys Glu Glu  Leu Asp Lys 
    1130                 1135                 1140             


Ile His  Lys Asn Gly Ser Gly  Gly Ser Gly Asp Ile  Ile Lys Leu 
    1145                 1150                 1155             


Leu Asn  Glu Gln Val Asn Lys  Glu Met Gln Ser Ser  Asn Leu Tyr 
    1160                 1165                 1170             


Met Ser  Met Ser Ser Trp Cys  Tyr Thr His Ser Leu  Asp Gly Ala 
    1175                 1180                 1185             


Gly Leu  Phe Leu Phe Asp His  Ala Ala Glu Glu Tyr  Glu His Ala 
    1190                 1195                 1200             


Lys Lys  Leu Ile Ile Phe Leu  Asn Glu Asn Asn Val  Pro Val Gln 
    1205                 1210                 1215             


Leu Thr  Ser Ile Ser Ala Pro  Glu His Lys Phe Glu  Gly Leu Thr 
    1220                 1225                 1230             


Gln Ile  Phe Gln Lys Ala Tyr  Glu His Glu Gln His  Ile Ser Glu 
    1235                 1240                 1245             


Ser Ile  Asn Asn Ile Val Asp  His Ala Ile Lys Ser  Lys Asp His 
    1250                 1255                 1260             


Ala Thr  Phe Asn Phe Leu Gln  Trp Tyr Val Ala Glu  Gln His Glu 
    1265                 1270                 1275             


Glu Glu  Val Leu Phe Lys Asp  Ile Leu Asp Lys Ile  Glu Leu Ile 
    1280                 1285                 1290             


Gly Asn  Glu Asn His Gly Leu  Tyr Leu Ala Asp Gln  Tyr Val Lys 
    1295                 1300                 1305             


Gly Ile  Ala Lys Ser Arg Lys  Ser Gly Ser 
    1310                 1315             


<210> 293
<211> 1332
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 293
Ser Ser Gln Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala 
1               5                   10                  15      


Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe 
            20                  25                  30          


Arg Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe 
        35                  40                  45              


Ser Asn Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly 
    50                  55                  60                  


Thr Lys Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr 
65                  70                  75                  80  


Phe Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly 
                85                  90                  95      


Thr Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala 
            100                 105                 110         


Thr Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro 
        115                 120                 125             


Phe Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser 
    130                 135                 140                 


Glu Phe Arg Val Tyr Ser Ser Ala Asn Gln Cys Thr Phe Glu Tyr Val 
145                 150                 155                 160 


Ser Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys 
                165                 170                 175     


Asn Leu Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile 
            180                 185                 190         


Tyr Ser Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly 
        195                 200                 205             


Phe Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile 
    210                 215                 220                 


Thr Arg Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro 
225                 230                 235                 240 


Gly Asp Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val 
                245                 250                 255     


Gly Tyr Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly 
            260                 265                 270         


Thr Ile Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr 
        275                 280                 285             


Lys Cys Thr Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr 
    290                 295                 300                 


Ser Asn Phe Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn 
305                 310                 315                 320 


Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe 
                325                 330                 335     


Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala 
            340                 345                 350         


Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys 
        355                 360                 365             


Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val 
    370                 375                 380                 


Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala 
385                 390                 395                 400 


Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp 
                405                 410                 415     


Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser 
            420                 425                 430         


Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser 
        435                 440                 445             


Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala 
    450                 455                 460                 


Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro 
465                 470                 475                 480 


Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro 
                485                 490                 495     


Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr 
            500                 505                 510         


Val Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val 
        515                 520                 525             


Asn Phe Asn Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser 
    530                 535                 540                 


Asn Lys Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp 
545                 550                 555                 560 


Thr Thr Asp Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile 
                565                 570                 575     


Thr Pro Cys Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn 
            580                 585                 590         


Thr Ser Asn Gln Val Ala Val Leu Tyr Gln Gly Val Asn Cys Thr Glu 
        595                 600                 605             


Val Pro Val Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val 
    610                 615                 620                 


Tyr Ser Thr Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile 
625                 630                 635                 640 


Gly Ala Glu His Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly 
                645                 650                 655     


Ala Gly Ile Cys Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro Gly Ser 
            660                 665                 670         


Ala Ser Ser Val Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu 
        675                 680                 685             


Gly Ala Glu Asn Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro 
    690                 695                 700                 


Thr Asn Phe Thr Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met 
705                 710                 715                 720 


Thr Lys Thr Ser Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr 
                725                 730                 735     


Glu Cys Ser Asn Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu 
            740                 745                 750         


Asn Arg Ala Leu Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln 
        755                 760                 765             


Glu Val Phe Ala Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys 
    770                 775                 780                 


Asp Phe Gly Gly Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys 
785                 790                 795                 800 


Pro Ser Lys Arg Ser Pro Ile Glu Asp Leu Leu Phe Asn Lys Val Thr 
                805                 810                 815     


Leu Ala Asp Ala Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp 
            820                 825                 830         


Ile Ala Ala Arg Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr 
        835                 840                 845             


Val Leu Pro Pro Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser 
    850                 855                 860                 


Ala Leu Leu Ala Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly 
865                 870                 875                 880 


Pro Ala Leu Gln Ile Pro Phe Pro Met Gln Met Ala Tyr Arg Phe Asn 
                885                 890                 895     


Gly Ile Gly Val Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile 
            900                 905                 910         


Ala Asn Gln Phe Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser 
        915                 920                 925             


Ser Thr Pro Ser Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn 
    930                 935                 940                 


Ala Gln Ala Leu Asn Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly 
945                 950                 955                 960 


Ala Ile Ser Ser Val Leu Asn Asp Ile Leu Ser Arg Leu Asp Pro Pro 
                965                 970                 975     


Glu Ala Glu Val Gln Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser 
            980                 985                 990         


Leu Gln Thr Tyr Val Thr Gln Gln  Leu Ile Arg Ala Ala  Glu Ile Arg 
        995                 1000                 1005             


Ala Ser  Ala Asn Leu Ala Ala  Thr Lys Met Ser Glu  Cys Val Leu 
    1010                 1015                 1020             


Gly Gln  Ser Lys Arg Val Asp  Phe Cys Gly Lys Gly  Tyr His Leu 
    1025                 1030                 1035             


Met Ser  Phe Pro Gln Ser Ala  Pro His Gly Val Val  Phe Leu His 
    1040                 1045                 1050             


Val Thr  Tyr Val Pro Ala Gln  Glu Lys Asn Phe Thr  Thr Ala Pro 
    1055                 1060                 1065             


Ala Ile  Cys His Asp Gly Lys  Ala His Phe Pro Arg  Glu Gly Val 
    1070                 1075                 1080             


Phe Val  Ser Asn Gly Thr His  Trp Phe Val Thr Gln  Arg Asn Phe 
    1085                 1090                 1095             


Tyr Glu  Pro Gln Ile Ile Thr  Thr Asp Asn Thr Phe  Val Ser Gly 
    1100                 1105                 1110             


Asn Cys  Asp Val Val Ile Gly  Ile Val Asn Asn Thr  Val Tyr Asp 
    1115                 1120                 1125             


Pro Leu  Gln Ser Glu Leu Asp  Ser Ile Lys Glu Glu  Leu Asp Lys 
    1130                 1135                 1140             


Ile His  Lys Asn Leu Asp Ser  Ile Lys Glu Glu Leu  Asp Lys Ile 
    1145                 1150                 1155             


His Lys  Asn Gly Ser Gly Gly  Ser Gly Asp Ile Ile  Lys Leu Leu 
    1160                 1165                 1170             


Asn Glu  Gln Val Asn Lys Glu  Met Gln Ser Ser Asn  Leu Tyr Met 
    1175                 1180                 1185             


Ser Met  Ser Ser Trp Cys Tyr  Thr His Ser Leu Asp  Gly Ala Gly 
    1190                 1195                 1200             


Leu Phe  Leu Phe Asp His Ala  Ala Glu Glu Tyr Glu  His Ala Lys 
    1205                 1210                 1215             


Lys Leu  Ile Ile Phe Leu Asn  Glu Asn Asn Val Pro  Val Gln Leu 
    1220                 1225                 1230             


Thr Ser  Ile Ser Ala Pro Glu  His Lys Phe Glu Gly  Leu Thr Gln 
    1235                 1240                 1245             


Ile Phe  Gln Lys Ala Tyr Glu  His Glu Gln His Ile  Ser Glu Ser 
    1250                 1255                 1260             


Ile Asn  Asn Ile Val Asp His  Ala Ile Lys Ser Lys  Asp His Ala 
    1265                 1270                 1275             


Thr Phe  Asn Phe Leu Gln Trp  Tyr Val Ala Glu Gln  His Glu Glu 
    1280                 1285                 1290             


Glu Val  Leu Phe Lys Asp Ile  Leu Asp Lys Ile Glu  Leu Ile Gly 
    1295                 1300                 1305             


Asn Glu  Asn His Gly Leu Tyr  Leu Ala Asp Gln Tyr  Val Lys Gly 
    1310                 1315                 1320             


Ile Ala  Lys Ser Arg Lys Ser  Gly Ser 
    1325                 1330         


<210> 294
<211> 1332
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 294
Ser Ser Gln Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala 
1               5                   10                  15      


Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe 
            20                  25                  30          


Arg Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe 
        35                  40                  45              


Ser Asn Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly 
    50                  55                  60                  


Thr Lys Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr 
65                  70                  75                  80  


Phe Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly 
                85                  90                  95      


Thr Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala 
            100                 105                 110         


Thr Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro 
        115                 120                 125             


Phe Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser 
    130                 135                 140                 


Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val 
145                 150                 155                 160 


Ser Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys 
                165                 170                 175     


Asn Leu Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile 
            180                 185                 190         


Tyr Ser Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly 
        195                 200                 205             


Phe Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Gln Ile 
    210                 215                 220                 


Thr Arg Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro 
225                 230                 235                 240 


Gly Asp Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val 
                245                 250                 255     


Gly Tyr Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly 
            260                 265                 270         


Thr Ile Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr 
        275                 280                 285             


Lys Cys Thr Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr 
    290                 295                 300                 


Ser Asn Phe Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn 
305                 310                 315                 320 


Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe 
                325                 330                 335     


Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala 
            340                 345                 350         


Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys 
        355                 360                 365             


Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val 
    370                 375                 380                 


Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala 
385                 390                 395                 400 


Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp 
                405                 410                 415     


Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser 
            420                 425                 430         


Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser 
        435                 440                 445             


Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala 
    450                 455                 460                 


Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro 
465                 470                 475                 480 


Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro 
                485                 490                 495     


Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr 
            500                 505                 510         


Val Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val 
        515                 520                 525             


Asn Phe Asn Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser 
    530                 535                 540                 


Asn Lys Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp 
545                 550                 555                 560 


Thr Thr Asp Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile 
                565                 570                 575     


Thr Pro Cys Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn 
            580                 585                 590         


Thr Ser Asn Gln Val Ala Val Leu Tyr Gln Gly Val Asn Cys Thr Glu 
        595                 600                 605             


Val Pro Val Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val 
    610                 615                 620                 


Tyr Ser Thr Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile 
625                 630                 635                 640 


Gly Ala Glu His Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly 
                645                 650                 655     


Ala Gly Ile Cys Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro Gly Ser 
            660                 665                 670         


Ala Ser Ser Val Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu 
        675                 680                 685             


Gly Ala Glu Asn Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro 
    690                 695                 700                 


Thr Asn Phe Thr Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met 
705                 710                 715                 720 


Thr Lys Thr Ser Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr 
                725                 730                 735     


Glu Cys Ser Asn Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu 
            740                 745                 750         


Asn Arg Ala Leu Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln 
        755                 760                 765             


Glu Val Phe Ala Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys 
    770                 775                 780                 


Asp Phe Gly Gly Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys 
785                 790                 795                 800 


Pro Ser Lys Arg Ser Pro Ile Glu Asp Leu Leu Phe Asn Lys Val Thr 
                805                 810                 815     


Leu Ala Asp Ala Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp 
            820                 825                 830         


Ile Ala Ala Arg Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr 
        835                 840                 845             


Val Leu Pro Pro Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser 
    850                 855                 860                 


Ala Leu Leu Ala Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly 
865                 870                 875                 880 


Pro Ala Leu Gln Ile Pro Phe Pro Met Gln Met Ala Tyr Arg Phe Asn 
                885                 890                 895     


Gly Ile Gly Val Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile 
            900                 905                 910         


Ala Asn Gln Phe Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser 
        915                 920                 925             


Ser Thr Pro Ser Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn 
    930                 935                 940                 


Ala Gln Ala Leu Asn Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly 
945                 950                 955                 960 


Ala Ile Ser Ser Val Leu Asn Asp Ile Leu Ser Arg Leu Asp Pro Pro 
                965                 970                 975     


Glu Ala Glu Val Gln Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser 
            980                 985                 990         


Leu Gln Thr Tyr Val Thr Gln Gln  Leu Ile Arg Ala Ala  Glu Ile Arg 
        995                 1000                 1005             


Ala Ser  Ala Asn Leu Ala Ala  Thr Lys Met Ser Glu  Cys Val Leu 
    1010                 1015                 1020             


Gly Gln  Ser Lys Arg Val Asp  Phe Cys Gly Lys Gly  Tyr His Leu 
    1025                 1030                 1035             


Met Ser  Phe Pro Gln Ser Ala  Pro His Gly Val Val  Phe Leu His 
    1040                 1045                 1050             


Val Thr  Tyr Val Pro Ala Gln  Glu Lys Asn Phe Thr  Thr Ala Pro 
    1055                 1060                 1065             


Ala Ile  Cys His Asp Gly Lys  Ala His Phe Pro Arg  Glu Gly Val 
    1070                 1075                 1080             


Phe Val  Ser Asn Gly Thr His  Trp Phe Val Thr Gln  Arg Asn Phe 
    1085                 1090                 1095             


Tyr Glu  Pro Gln Ile Ile Thr  Thr Asp Asn Thr Phe  Val Ser Gly 
    1100                 1105                 1110             


Asn Cys  Asp Val Val Ile Gly  Ile Val Asn Asn Thr  Val Tyr Asp 
    1115                 1120                 1125             


Pro Leu  Gln Ser Glu Leu Asp  Ser Ile Lys Glu Glu  Leu Asp Lys 
    1130                 1135                 1140             


Ile His  Lys Asn Leu Asp Ser  Ile Lys Glu Glu Leu  Asp Lys Ile 
    1145                 1150                 1155             


His Lys  Asn Gly Ser Gly Gly  Ser Gly Asp Ile Ile  Lys Leu Leu 
    1160                 1165                 1170             


Asn Glu  Gln Val Asn Lys Glu  Met Gln Ser Ser Asn  Leu Tyr Met 
    1175                 1180                 1185             


Ser Met  Ser Ser Trp Cys Tyr  Thr His Ser Leu Asp  Gly Ala Gly 
    1190                 1195                 1200             


Leu Phe  Leu Phe Asp His Ala  Ala Glu Glu Tyr Glu  His Ala Lys 
    1205                 1210                 1215             


Lys Leu  Ile Ile Phe Leu Asn  Glu Asn Asn Val Pro  Val Gln Leu 
    1220                 1225                 1230             


Thr Ser  Ile Ser Ala Pro Glu  His Lys Phe Glu Gly  Leu Thr Gln 
    1235                 1240                 1245             


Ile Phe  Gln Lys Ala Tyr Glu  His Glu Gln His Ile  Ser Glu Ser 
    1250                 1255                 1260             


Ile Asn  Asn Ile Val Asp His  Ala Ile Lys Ser Lys  Asp His Ala 
    1265                 1270                 1275             


Thr Phe  Asn Phe Leu Gln Trp  Tyr Val Ala Glu Gln  His Glu Glu 
    1280                 1285                 1290             


Glu Val  Leu Phe Lys Asp Ile  Leu Asp Lys Ile Glu  Leu Ile Gly 
    1295                 1300                 1305             


Asn Glu  Asn His Gly Leu Tyr  Leu Ala Asp Gln Tyr  Val Lys Gly 
    1310                 1315                 1320             


Ile Ala  Lys Ser Arg Lys Ser  Gly Ser 
    1325                 1330         


<210> 295
<211> 1318
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 295
Ser Ser Gln Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala 
1               5                   10                  15      


Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe 
            20                  25                  30          


Arg Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe 
        35                  40                  45              


Ser Asn Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly 
    50                  55                  60                  


Thr Lys Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr 
65                  70                  75                  80  


Phe Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly 
                85                  90                  95      


Thr Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala 
            100                 105                 110         


Thr Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro 
        115                 120                 125             


Phe Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser 
    130                 135                 140                 


Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val 
145                 150                 155                 160 


Ser Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys 
                165                 170                 175     


Asn Leu Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile 
            180                 185                 190         


Tyr Ser Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly 
        195                 200                 205             


Phe Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile 
    210                 215                 220                 


Thr Arg Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro 
225                 230                 235                 240 


Gly Asp Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val 
                245                 250                 255     


Gly Tyr Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly 
            260                 265                 270         


Thr Ile Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr 
        275                 280                 285             


Lys Cys Thr Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr 
    290                 295                 300                 


Ser Asn Phe Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn 
305                 310                 315                 320 


Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe 
                325                 330                 335     


Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala 
            340                 345                 350         


Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys 
        355                 360                 365             


Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val 
    370                 375                 380                 


Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala 
385                 390                 395                 400 


Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp 
                405                 410                 415     


Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser 
            420                 425                 430         


Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser 
        435                 440                 445             


Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala 
    450                 455                 460                 


Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro 
465                 470                 475                 480 


Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro 
                485                 490                 495     


Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr 
            500                 505                 510         


Val Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val 
        515                 520                 525             


Asn Phe Asn Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser 
    530                 535                 540                 


Asn Lys Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp 
545                 550                 555                 560 


Thr Thr Asp Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile 
                565                 570                 575     


Thr Pro Cys Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn 
            580                 585                 590         


Thr Ser Asn Gln Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu 
        595                 600                 605             


Val Pro Val Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val 
    610                 615                 620                 


Tyr Ser Thr Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile 
625                 630                 635                 640 


Gly Ala Glu His Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly 
                645                 650                 655     


Ala Gly Ile Cys Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro Gly Ser 
            660                 665                 670         


Ala Ser Ser Val Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu 
        675                 680                 685             


Gly Ala Glu Asn Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro 
    690                 695                 700                 


Thr Asn Phe Thr Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met 
705                 710                 715                 720 


Thr Lys Thr Ser Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr 
                725                 730                 735     


Glu Cys Ser Asn Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu 
            740                 745                 750         


Asn Arg Ala Leu Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln 
        755                 760                 765             


Glu Val Phe Ala Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys 
    770                 775                 780                 


Asp Phe Gly Gly Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys 
785                 790                 795                 800 


Pro Ser Lys Arg Ser Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr 
                805                 810                 815     


Leu Ala Asp Ala Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp 
            820                 825                 830         


Ile Ala Ala Arg Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr 
        835                 840                 845             


Val Leu Pro Pro Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser 
    850                 855                 860                 


Ala Leu Leu Ala Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly 
865                 870                 875                 880 


Ala Ala Leu Gln Ile Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn 
                885                 890                 895     


Gly Ile Gly Val Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile 
            900                 905                 910         


Ala Asn Gln Phe Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser 
        915                 920                 925             


Ser Thr Ala Ser Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn 
    930                 935                 940                 


Ala Gln Ala Leu Asn Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly 
945                 950                 955                 960 


Ala Ile Ser Ser Val Leu Asn Asp Ile Leu Ser Arg Leu Asp Pro Pro 
                965                 970                 975     


Glu Ala Glu Val Gln Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser 
            980                 985                 990         


Leu Gln Thr Tyr Val Thr Gln Gln  Leu Ile Arg Ala Ala  Glu Ile Arg 
        995                 1000                 1005             


Ala Ser  Ala Asn Leu Ala Ala  Thr Lys Met Ser Glu  Cys Val Leu 
    1010                 1015                 1020             


Gly Gln  Ser Lys Arg Val Asp  Phe Cys Gly Lys Gly  Tyr His Leu 
    1025                 1030                 1035             


Met Ser  Phe Pro Gln Ser Ala  Pro His Gly Val Val  Phe Leu His 
    1040                 1045                 1050             


Val Thr  Tyr Val Pro Ala Gln  Glu Lys Asn Phe Thr  Thr Ala Pro 
    1055                 1060                 1065             


Ala Ile  Cys His Asp Gly Lys  Ala His Phe Pro Arg  Glu Gly Val 
    1070                 1075                 1080             


Phe Val  Ser Asn Gly Thr His  Trp Phe Val Thr Gln  Arg Asn Phe 
    1085                 1090                 1095             


Tyr Glu  Pro Gln Ile Ile Thr  Thr Asp Asn Thr Phe  Val Ser Gly 
    1100                 1105                 1110             


Asn Cys  Asp Val Val Ile Gly  Ile Val Asn Asn Thr  Val Tyr Asp 
    1115                 1120                 1125             


Pro Leu  Gln Ser Glu Leu Asp  Ser Ile Lys Glu Glu  Leu Asp Lys 
    1130                 1135                 1140             


Ile His  Lys Asn Gly Ser Gly  Gly Ser Gly Asp Ile  Ile Lys Leu 
    1145                 1150                 1155             


Leu Asn  Glu Gln Val Asn Lys  Glu Met Gln Ser Ser  Asn Leu Tyr 
    1160                 1165                 1170             


Met Ser  Met Ser Ser Trp Cys  Tyr Thr His Ser Leu  Asp Gly Ala 
    1175                 1180                 1185             


Gly Leu  Phe Leu Phe Asp His  Ala Ala Glu Glu Tyr  Glu His Ala 
    1190                 1195                 1200             


Lys Lys  Leu Ile Ile Phe Leu  Asn Glu Asn Asn Val  Pro Val Gln 
    1205                 1210                 1215             


Leu Thr  Ser Ile Ser Ala Pro  Glu His Lys Phe Glu  Gly Leu Thr 
    1220                 1225                 1230             


Gln Ile  Phe Gln Lys Ala Tyr  Glu His Glu Gln His  Ile Ser Glu 
    1235                 1240                 1245             


Ser Ile  Asn Asn Ile Val Asp  His Ala Ile Lys Ser  Lys Asp His 
    1250                 1255                 1260             


Ala Thr  Phe Asn Phe Leu Gln  Trp Tyr Val Ala Glu  Gln His Glu 
    1265                 1270                 1275             


Glu Glu  Val Leu Phe Lys Asp  Ile Leu Asp Lys Ile  Glu Leu Ile 
    1280                 1285                 1290             


Gly Asn  Glu Thr His Gly Leu  Tyr Leu Ala Asp Gln  Tyr Val Lys 
    1295                 1300                 1305             


Gly Ile  Ala Lys Ser Arg Lys  Ser Gly Ser 
    1310                 1315             


<210> 296
<211> 1318
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 296
Ser Ser Gln Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala 
1               5                   10                  15      


Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe 
            20                  25                  30          


Arg Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe 
        35                  40                  45              


Ser Asn Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly 
    50                  55                  60                  


Thr Lys Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr 
65                  70                  75                  80  


Phe Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly 
                85                  90                  95      


Thr Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala 
            100                 105                 110         


Thr Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro 
        115                 120                 125             


Phe Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser 
    130                 135                 140                 


Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val 
145                 150                 155                 160 


Ser Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys 
                165                 170                 175     


Asn Leu Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile 
            180                 185                 190         


Tyr Ser Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly 
        195                 200                 205             


Phe Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile 
    210                 215                 220                 


Thr Arg Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro 
225                 230                 235                 240 


Gly Asp Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val 
                245                 250                 255     


Gly Tyr Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly 
            260                 265                 270         


Thr Ile Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr 
        275                 280                 285             


Lys Cys Thr Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr 
    290                 295                 300                 


Ser Asn Phe Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn 
305                 310                 315                 320 


Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe 
                325                 330                 335     


Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala 
            340                 345                 350         


Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys 
        355                 360                 365             


Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val 
    370                 375                 380                 


Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala 
385                 390                 395                 400 


Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp 
                405                 410                 415     


Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser 
            420                 425                 430         


Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser 
        435                 440                 445             


Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala 
    450                 455                 460                 


Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro 
465                 470                 475                 480 


Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro 
                485                 490                 495     


Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr 
            500                 505                 510         


Val Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val 
        515                 520                 525             


Asn Phe Asn Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser 
    530                 535                 540                 


Asn Lys Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp 
545                 550                 555                 560 


Thr Thr Asp Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile 
                565                 570                 575     


Thr Pro Cys Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn 
            580                 585                 590         


Thr Ser Asn Gln Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu 
        595                 600                 605             


Val Pro Val Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val 
    610                 615                 620                 


Tyr Ser Thr Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile 
625                 630                 635                 640 


Gly Ala Glu His Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly 
                645                 650                 655     


Ala Gly Ile Cys Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro Gly Ser 
            660                 665                 670         


Ala Ser Ser Val Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu 
        675                 680                 685             


Gly Ala Glu Asn Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro 
    690                 695                 700                 


Thr Asn Phe Thr Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met 
705                 710                 715                 720 


Thr Lys Thr Ser Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr 
                725                 730                 735     


Glu Cys Ser Asn Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu 
            740                 745                 750         


Asn Arg Ala Leu Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln 
        755                 760                 765             


Glu Val Phe Ala Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys 
    770                 775                 780                 


Asp Phe Gly Gly Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys 
785                 790                 795                 800 


Pro Ser Lys Arg Ser Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr 
                805                 810                 815     


Leu Ala Asp Ala Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp 
            820                 825                 830         


Ile Ala Ala Arg Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr 
        835                 840                 845             


Val Leu Pro Pro Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser 
    850                 855                 860                 


Ala Leu Leu Ala Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly 
865                 870                 875                 880 


Ala Ala Leu Gln Ile Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn 
                885                 890                 895     


Gly Ile Gly Val Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile 
            900                 905                 910         


Ala Asn Gln Phe Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser 
        915                 920                 925             


Ser Thr Ala Ser Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn 
    930                 935                 940                 


Ala Gln Ala Leu Asn Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly 
945                 950                 955                 960 


Ala Ile Ser Ser Val Leu Asn Asp Ile Leu Ser Arg Leu Asp Pro Pro 
                965                 970                 975     


Glu Ala Glu Val Gln Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser 
            980                 985                 990         


Leu Gln Thr Tyr Val Thr Gln Gln  Leu Ile Arg Ala Ala  Glu Ile Arg 
        995                 1000                 1005             


Ala Ser  Ala Asn Leu Ala Ala  Thr Lys Met Ser Glu  Cys Val Leu 
    1010                 1015                 1020             


Gly Gln  Ser Lys Arg Val Asp  Phe Cys Gly Lys Gly  Tyr His Leu 
    1025                 1030                 1035             


Met Ser  Phe Pro Gln Ser Ala  Pro His Gly Val Val  Phe Leu His 
    1040                 1045                 1050             


Val Thr  Tyr Val Pro Ala Gln  Glu Lys Asn Phe Thr  Thr Ala Pro 
    1055                 1060                 1065             


Ala Ile  Cys His Asp Gly Lys  Ala His Phe Pro Arg  Glu Gly Val 
    1070                 1075                 1080             


Phe Val  Ser Asn Gly Thr His  Trp Phe Val Thr Gln  Arg Asn Phe 
    1085                 1090                 1095             


Tyr Glu  Pro Gln Ile Ile Thr  Thr Asp Asn Thr Phe  Val Ser Gly 
    1100                 1105                 1110             


Asn Cys  Asp Val Val Ile Gly  Ile Val Asn Asn Thr  Val Tyr Asp 
    1115                 1120                 1125             


Pro Leu  Gln Ser Glu Leu Asp  Ser Ile Lys Glu Glu  Leu Asp Lys 
    1130                 1135                 1140             


Ile His  Lys Asn Gly Ser Gly  Gly Ser Gly Asp Ile  Ile Lys Leu 
    1145                 1150                 1155             


Leu Asn  Glu Gln Val Asn Lys  Glu Met Gln Ser Ser  Asn Leu Tyr 
    1160                 1165                 1170             


Met Ser  Met Ser Ser Trp Cys  Tyr Thr His Ser Leu  Asp Gly Ala 
    1175                 1180                 1185             


Gly Leu  Phe Leu Phe Asp His  Ala Ala Glu Glu Tyr  Glu His Ala 
    1190                 1195                 1200             


Lys Lys  Leu Ile Ile Phe Leu  Asn Glu Asn Asn Val  Pro Val Gln 
    1205                 1210                 1215             


Leu Thr  Ser Ile Ser Ala Pro  Asn His Ser Phe Glu  Gly Leu Thr 
    1220                 1225                 1230             


Gln Ile  Phe Gln Lys Ala Tyr  Glu His Glu Gln His  Ile Ser Glu 
    1235                 1240                 1245             


Ser Ile  Asn Asn Ile Val Asp  His Ala Ile Lys Ser  Lys Asp His 
    1250                 1255                 1260             


Ala Thr  Phe Asn Phe Leu Gln  Trp Tyr Val Ala Glu  Gln His Glu 
    1265                 1270                 1275             


Glu Glu  Val Leu Phe Lys Asp  Ile Leu Asp Lys Ile  Glu Leu Ile 
    1280                 1285                 1290             


Gly Asn  Glu Asn His Gly Leu  Tyr Leu Ala Asp Gln  Tyr Val Lys 
    1295                 1300                 1305             


Gly Ile  Ala Lys Ser Arg Lys  Ser Gly Ser 
    1310                 1315             


<210> 297
<211> 1318
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 297
Ser Ser Gln Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala 
1               5                   10                  15      


Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe 
            20                  25                  30          


Arg Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe 
        35                  40                  45              


Ser Asn Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly 
    50                  55                  60                  


Thr Lys Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr 
65                  70                  75                  80  


Phe Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly 
                85                  90                  95      


Thr Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala 
            100                 105                 110         


Thr Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro 
        115                 120                 125             


Phe Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser 
    130                 135                 140                 


Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val 
145                 150                 155                 160 


Ser Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys 
                165                 170                 175     


Asn Leu Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile 
            180                 185                 190         


Tyr Ser Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly 
        195                 200                 205             


Phe Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile 
    210                 215                 220                 


Thr Arg Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro 
225                 230                 235                 240 


Gly Asp Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val 
                245                 250                 255     


Gly Tyr Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly 
            260                 265                 270         


Thr Ile Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr 
        275                 280                 285             


Lys Cys Thr Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr 
    290                 295                 300                 


Ser Asn Phe Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn 
305                 310                 315                 320 


Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe 
                325                 330                 335     


Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala 
            340                 345                 350         


Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys 
        355                 360                 365             


Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val 
    370                 375                 380                 


Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala 
385                 390                 395                 400 


Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp 
                405                 410                 415     


Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser 
            420                 425                 430         


Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser 
        435                 440                 445             


Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala 
    450                 455                 460                 


Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro 
465                 470                 475                 480 


Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro 
                485                 490                 495     


Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr 
            500                 505                 510         


Val Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val 
        515                 520                 525             


Asn Phe Asn Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser 
    530                 535                 540                 


Asn Lys Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp 
545                 550                 555                 560 


Thr Thr Asp Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile 
                565                 570                 575     


Thr Pro Cys Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn 
            580                 585                 590         


Thr Ser Asn Gln Val Ala Val Leu Tyr Gln Gly Val Asn Cys Thr Glu 
        595                 600                 605             


Val Pro Val Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val 
    610                 615                 620                 


Tyr Ser Thr Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile 
625                 630                 635                 640 


Gly Ala Glu His Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly 
                645                 650                 655     


Ala Gly Ile Cys Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro Gly Ser 
            660                 665                 670         


Ala Ser Ser Val Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu 
        675                 680                 685             


Gly Ala Glu Asn Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro 
    690                 695                 700                 


Thr Asn Phe Thr Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met 
705                 710                 715                 720 


Thr Lys Thr Ser Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr 
                725                 730                 735     


Glu Cys Ser Asn Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu 
            740                 745                 750         


Asn Arg Ala Leu Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln 
        755                 760                 765             


Glu Val Phe Ala Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys 
    770                 775                 780                 


Asp Phe Gly Gly Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys 
785                 790                 795                 800 


Pro Ser Lys Arg Ser Pro Ile Glu Asp Leu Leu Phe Asn Lys Val Thr 
                805                 810                 815     


Leu Ala Asp Ala Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp 
            820                 825                 830         


Ile Ala Ala Arg Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr 
        835                 840                 845             


Val Leu Pro Pro Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser 
    850                 855                 860                 


Ala Leu Leu Ala Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly 
865                 870                 875                 880 


Pro Ala Leu Gln Ile Pro Phe Pro Met Gln Met Ala Tyr Arg Phe Asn 
                885                 890                 895     


Gly Ile Gly Val Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile 
            900                 905                 910         


Ala Asn Gln Phe Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser 
        915                 920                 925             


Ser Thr Pro Ser Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn 
    930                 935                 940                 


Ala Gln Ala Leu Asn Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly 
945                 950                 955                 960 


Ala Ile Ser Ser Val Leu Asn Asp Ile Leu Ser Arg Leu Asp Pro Pro 
                965                 970                 975     


Glu Ala Glu Val Gln Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser 
            980                 985                 990         


Leu Gln Thr Tyr Val Thr Gln Gln  Leu Ile Arg Ala Ala  Glu Ile Arg 
        995                 1000                 1005             


Ala Ser  Ala Asn Leu Ala Ala  Thr Lys Met Ser Glu  Cys Val Leu 
    1010                 1015                 1020             


Gly Gln  Ser Lys Arg Val Asp  Phe Cys Gly Lys Gly  Tyr His Leu 
    1025                 1030                 1035             


Met Ser  Phe Pro Gln Ser Ala  Pro His Gly Val Val  Phe Leu His 
    1040                 1045                 1050             


Val Thr  Tyr Val Pro Ala Gln  Glu Lys Asn Phe Thr  Thr Ala Pro 
    1055                 1060                 1065             


Ala Ile  Cys His Asp Gly Lys  Ala His Phe Pro Arg  Glu Gly Val 
    1070                 1075                 1080             


Phe Val  Ser Asn Gly Thr His  Trp Phe Val Thr Gln  Arg Asn Phe 
    1085                 1090                 1095             


Tyr Glu  Pro Gln Ile Ile Thr  Thr Asp Asn Thr Phe  Val Ser Gly 
    1100                 1105                 1110             


Asn Cys  Asp Val Val Ile Gly  Ile Val Asn Asn Thr  Val Tyr Asp 
    1115                 1120                 1125             


Pro Leu  Gln Ser Glu Leu Asp  Ser Ile Lys Glu Glu  Leu Asp Lys 
    1130                 1135                 1140             


Ile His  Lys Asn Gly Ser Gly  Gly Ser Gly Asp Ile  Ile Lys Leu 
    1145                 1150                 1155             


Leu Asn  Glu Gln Val Asn Lys  Glu Met Gln Ser Ser  Asn Leu Tyr 
    1160                 1165                 1170             


Met Ser  Met Ser Ser Trp Cys  Tyr Thr His Ser Leu  Asp Gly Ala 
    1175                 1180                 1185             


Gly Leu  Phe Leu Phe Asp His  Ala Ala Glu Glu Tyr  Glu His Ala 
    1190                 1195                 1200             


Lys Lys  Leu Ile Ile Phe Leu  Asn Glu Asn Asn Val  Pro Val Gln 
    1205                 1210                 1215             


Leu Thr  Ser Ile Ser Ala Pro  Glu His Lys Phe Glu  Gly Leu Thr 
    1220                 1225                 1230             


Gln Ile  Phe Gln Lys Ala Tyr  Glu His Glu Gln His  Ile Ser Glu 
    1235                 1240                 1245             


Ser Ile  Asn Asn Ile Val Asp  His Ala Ile Lys Ser  Lys Asp His 
    1250                 1255                 1260             


Ala Thr  Phe Asn Phe Leu Gln  Trp Tyr Val Ala Glu  Gln His Glu 
    1265                 1270                 1275             


Glu Glu  Val Leu Phe Lys Asp  Ile Leu Asp Lys Ile  Glu Leu Ile 
    1280                 1285                 1290             


Gly Asn  Glu Thr His Gly Leu  Tyr Leu Ala Asp Gln  Tyr Val Lys 
    1295                 1300                 1305             


Gly Ile  Ala Lys Ser Arg Lys  Ser Gly Ser 
    1310                 1315             


<210> 298
<211> 1318
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 298
Ser Ser Gln Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala 
1               5                   10                  15      


Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe 
            20                  25                  30          


Arg Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe 
        35                  40                  45              


Ser Asn Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly 
    50                  55                  60                  


Thr Lys Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr 
65                  70                  75                  80  


Phe Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly 
                85                  90                  95      


Thr Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala 
            100                 105                 110         


Thr Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro 
        115                 120                 125             


Phe Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser 
    130                 135                 140                 


Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val 
145                 150                 155                 160 


Ser Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys 
                165                 170                 175     


Asn Leu Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile 
            180                 185                 190         


Tyr Ser Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly 
        195                 200                 205             


Phe Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile 
    210                 215                 220                 


Thr Arg Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro 
225                 230                 235                 240 


Gly Asp Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val 
                245                 250                 255     


Gly Tyr Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly 
            260                 265                 270         


Thr Ile Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr 
        275                 280                 285             


Lys Cys Thr Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr 
    290                 295                 300                 


Ser Asn Phe Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn 
305                 310                 315                 320 


Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe 
                325                 330                 335     


Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala 
            340                 345                 350         


Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys 
        355                 360                 365             


Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val 
    370                 375                 380                 


Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala 
385                 390                 395                 400 


Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp 
                405                 410                 415     


Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser 
            420                 425                 430         


Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser 
        435                 440                 445             


Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala 
    450                 455                 460                 


Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro 
465                 470                 475                 480 


Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro 
                485                 490                 495     


Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr 
            500                 505                 510         


Val Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val 
        515                 520                 525             


Asn Phe Asn Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser 
    530                 535                 540                 


Asn Lys Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp 
545                 550                 555                 560 


Thr Thr Asp Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile 
                565                 570                 575     


Thr Pro Cys Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn 
            580                 585                 590         


Thr Ser Asn Gln Val Ala Val Leu Tyr Gln Gly Val Asn Cys Thr Glu 
        595                 600                 605             


Val Pro Val Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val 
    610                 615                 620                 


Tyr Ser Thr Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile 
625                 630                 635                 640 


Gly Ala Glu His Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly 
                645                 650                 655     


Ala Gly Ile Cys Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro Gly Ser 
            660                 665                 670         


Ala Ser Ser Val Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu 
        675                 680                 685             


Gly Ala Glu Asn Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro 
    690                 695                 700                 


Thr Asn Phe Thr Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met 
705                 710                 715                 720 


Thr Lys Thr Ser Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr 
                725                 730                 735     


Glu Cys Ser Asn Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu 
            740                 745                 750         


Asn Arg Ala Leu Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln 
        755                 760                 765             


Glu Val Phe Ala Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys 
    770                 775                 780                 


Asp Phe Gly Gly Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys 
785                 790                 795                 800 


Pro Ser Lys Arg Ser Pro Ile Glu Asp Leu Leu Phe Asn Lys Val Thr 
                805                 810                 815     


Leu Ala Asp Ala Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp 
            820                 825                 830         


Ile Ala Ala Arg Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr 
        835                 840                 845             


Val Leu Pro Pro Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser 
    850                 855                 860                 


Ala Leu Leu Ala Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly 
865                 870                 875                 880 


Pro Ala Leu Gln Ile Pro Phe Pro Met Gln Met Ala Tyr Arg Phe Asn 
                885                 890                 895     


Gly Ile Gly Val Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile 
            900                 905                 910         


Ala Asn Gln Phe Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser 
        915                 920                 925             


Ser Thr Pro Ser Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn 
    930                 935                 940                 


Ala Gln Ala Leu Asn Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly 
945                 950                 955                 960 


Ala Ile Ser Ser Val Leu Asn Asp Ile Leu Ser Arg Leu Asp Pro Pro 
                965                 970                 975     


Glu Ala Glu Val Gln Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser 
            980                 985                 990         


Leu Gln Thr Tyr Val Thr Gln Gln  Leu Ile Arg Ala Ala  Glu Ile Arg 
        995                 1000                 1005             


Ala Ser  Ala Asn Leu Ala Ala  Thr Lys Met Ser Glu  Cys Val Leu 
    1010                 1015                 1020             


Gly Gln  Ser Lys Arg Val Asp  Phe Cys Gly Lys Gly  Tyr His Leu 
    1025                 1030                 1035             


Met Ser  Phe Pro Gln Ser Ala  Pro His Gly Val Val  Phe Leu His 
    1040                 1045                 1050             


Val Thr  Tyr Val Pro Ala Gln  Glu Lys Asn Phe Thr  Thr Ala Pro 
    1055                 1060                 1065             


Ala Ile  Cys His Asp Gly Lys  Ala His Phe Pro Arg  Glu Gly Val 
    1070                 1075                 1080             


Phe Val  Ser Asn Gly Thr His  Trp Phe Val Thr Gln  Arg Asn Phe 
    1085                 1090                 1095             


Tyr Glu  Pro Gln Ile Ile Thr  Thr Asp Asn Thr Phe  Val Ser Gly 
    1100                 1105                 1110             


Asn Cys  Asp Val Val Ile Gly  Ile Val Asn Asn Thr  Val Tyr Asp 
    1115                 1120                 1125             


Pro Leu  Gln Ser Glu Leu Asp  Ser Ile Lys Glu Glu  Leu Asp Lys 
    1130                 1135                 1140             


Ile His  Lys Asn Gly Ser Gly  Gly Ser Gly Asp Ile  Ile Lys Leu 
    1145                 1150                 1155             


Leu Asn  Glu Gln Val Asn Lys  Glu Met Gln Ser Ser  Asn Leu Tyr 
    1160                 1165                 1170             


Met Ser  Met Ser Ser Trp Cys  Tyr Thr His Ser Leu  Asp Gly Ala 
    1175                 1180                 1185             


Gly Leu  Phe Leu Phe Asp His  Ala Ala Glu Glu Tyr  Glu His Ala 
    1190                 1195                 1200             


Lys Lys  Leu Ile Ile Phe Leu  Asn Glu Asn Asn Val  Pro Val Gln 
    1205                 1210                 1215             


Leu Thr  Ser Ile Ser Ala Pro  Asn His Ser Phe Glu  Gly Leu Thr 
    1220                 1225                 1230             


Gln Ile  Phe Gln Lys Ala Tyr  Glu His Glu Gln His  Ile Ser Glu 
    1235                 1240                 1245             


Ser Ile  Asn Asn Ile Val Asp  His Ala Ile Lys Ser  Lys Asp His 
    1250                 1255                 1260             


Ala Thr  Phe Asn Phe Leu Gln  Trp Tyr Val Ala Glu  Gln His Glu 
    1265                 1270                 1275             


Glu Glu  Val Leu Phe Lys Asp  Ile Leu Asp Lys Ile  Glu Leu Ile 
    1280                 1285                 1290             


Gly Asn  Glu Asn His Gly Leu  Tyr Leu Ala Asp Gln  Tyr Val Lys 
    1295                 1300                 1305             


Gly Ile  Ala Lys Ser Arg Lys  Ser Gly Ser 
    1310                 1315             


<210> 299
<211> 1332
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 299
Ser Ser Gln Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala 
1               5                   10                  15      


Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe 
            20                  25                  30          


Arg Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe 
        35                  40                  45              


Ser Asn Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly 
    50                  55                  60                  


Thr Lys Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr 
65                  70                  75                  80  


Phe Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly 
                85                  90                  95      


Thr Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala 
            100                 105                 110         


Thr Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro 
        115                 120                 125             


Phe Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser 
    130                 135                 140                 


Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val 
145                 150                 155                 160 


Ser Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys 
                165                 170                 175     


Asn Leu Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile 
            180                 185                 190         


Tyr Ser Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly 
        195                 200                 205             


Phe Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile 
    210                 215                 220                 


Thr Arg Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro 
225                 230                 235                 240 


Gly Asp Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val 
                245                 250                 255     


Gly Tyr Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly 
            260                 265                 270         


Thr Ile Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr 
        275                 280                 285             


Lys Cys Thr Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr 
    290                 295                 300                 


Ser Asn Phe Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn 
305                 310                 315                 320 


Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe 
                325                 330                 335     


Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala 
            340                 345                 350         


Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys 
        355                 360                 365             


Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val 
    370                 375                 380                 


Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala 
385                 390                 395                 400 


Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp 
                405                 410                 415     


Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser 
            420                 425                 430         


Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser 
        435                 440                 445             


Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala 
    450                 455                 460                 


Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro 
465                 470                 475                 480 


Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro 
                485                 490                 495     


Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr 
            500                 505                 510         


Val Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val 
        515                 520                 525             


Asn Phe Asn Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser 
    530                 535                 540                 


Asn Lys Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp 
545                 550                 555                 560 


Thr Thr Asp Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile 
                565                 570                 575     


Thr Pro Cys Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn 
            580                 585                 590         


Thr Ser Asn Gln Val Ala Val Leu Tyr Gln Gly Val Asn Cys Thr Glu 
        595                 600                 605             


Val Pro Val Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val 
    610                 615                 620                 


Tyr Ser Thr Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile 
625                 630                 635                 640 


Gly Ala Glu His Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly 
                645                 650                 655     


Ala Gly Ile Cys Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro Gly Ser 
            660                 665                 670         


Ala Ser Ser Val Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu 
        675                 680                 685             


Gly Ala Glu Asn Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro 
    690                 695                 700                 


Thr Asn Phe Thr Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met 
705                 710                 715                 720 


Thr Lys Thr Ser Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr 
                725                 730                 735     


Glu Cys Ser Asn Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu 
            740                 745                 750         


Asn Arg Ala Leu Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln 
        755                 760                 765             


Glu Val Phe Ala Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys 
    770                 775                 780                 


Asp Phe Gly Gly Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys 
785                 790                 795                 800 


Pro Ser Lys Arg Ser Pro Ile Glu Asp Leu Leu Phe Asn Lys Val Thr 
                805                 810                 815     


Leu Ala Asp Ala Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp 
            820                 825                 830         


Ile Ala Ala Arg Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr 
        835                 840                 845             


Val Leu Pro Pro Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser 
    850                 855                 860                 


Ala Leu Leu Ala Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly 
865                 870                 875                 880 


Pro Ala Leu Gln Ile Pro Phe Pro Met Gln Met Ala Tyr Arg Phe Asn 
                885                 890                 895     


Gly Ile Gly Val Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile 
            900                 905                 910         


Ala Asn Gln Phe Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser 
        915                 920                 925             


Ser Thr Pro Ser Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn 
    930                 935                 940                 


Ala Gln Ala Leu Asn Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly 
945                 950                 955                 960 


Ala Ile Ser Ser Val Leu Asn Asp Ile Leu Ser Arg Leu Asp Pro Pro 
                965                 970                 975     


Glu Ala Glu Val Gln Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser 
            980                 985                 990         


Leu Gln Thr Tyr Val Thr Gln Gln  Leu Ile Arg Ala Ala  Glu Ile Arg 
        995                 1000                 1005             


Ala Ser  Ala Asn Leu Ala Ala  Thr Lys Met Ser Glu  Cys Val Leu 
    1010                 1015                 1020             


Gly Gln  Ser Lys Arg Val Asp  Phe Cys Gly Lys Gly  Tyr His Leu 
    1025                 1030                 1035             


Met Ser  Phe Pro Gln Ser Ala  Pro His Gly Val Val  Phe Leu His 
    1040                 1045                 1050             


Val Thr  Tyr Val Pro Ala Gln  Glu Lys Asn Phe Thr  Thr Ala Pro 
    1055                 1060                 1065             


Ala Ile  Cys His Asp Gly Lys  Ala His Phe Pro Arg  Glu Gly Val 
    1070                 1075                 1080             


Phe Val  Ser Asn Gly Thr His  Trp Phe Val Thr Gln  Arg Asn Phe 
    1085                 1090                 1095             


Tyr Glu  Pro Gln Ile Ile Thr  Thr Asp Asn Thr Phe  Val Ser Gly 
    1100                 1105                 1110             


Asn Cys  Asp Val Val Ile Gly  Ile Val Asn Asn Thr  Val Tyr Asp 
    1115                 1120                 1125             


Pro Leu  Gln Ser Glu Leu Asp  Ser Ile Lys Glu Glu  Leu Asp Lys 
    1130                 1135                 1140             


Ile His  Lys Asn Leu Asp Ser  Ile Lys Glu Glu Leu  Asp Lys Ile 
    1145                 1150                 1155             


His Lys  Asn Gly Ser Gly Gly  Ser Gly Asp Ile Ile  Lys Leu Leu 
    1160                 1165                 1170             


Asn Glu  Gln Val Asn Lys Glu  Met Gln Ser Ser Asn  Leu Tyr Met 
    1175                 1180                 1185             


Ser Met  Ser Ser Trp Cys Tyr  Thr His Ser Leu Asp  Gly Ala Gly 
    1190                 1195                 1200             


Leu Phe  Leu Phe Asp His Ala  Ala Glu Glu Tyr Glu  His Ala Lys 
    1205                 1210                 1215             


Lys Leu  Ile Ile Phe Leu Asn  Glu Asn Asn Val Pro  Val Gln Leu 
    1220                 1225                 1230             


Thr Ser  Ile Ser Ala Pro Glu  His Lys Phe Glu Gly  Leu Thr Gln 
    1235                 1240                 1245             


Ile Phe  Gln Lys Ala Tyr Glu  His Glu Gln His Ile  Ser Glu Ser 
    1250                 1255                 1260             


Ile Asn  Asn Ile Val Asp His  Ala Ile Lys Ser Lys  Asp His Ala 
    1265                 1270                 1275             


Thr Phe  Asn Phe Leu Gln Trp  Tyr Val Ala Glu Gln  His Glu Glu 
    1280                 1285                 1290             


Glu Val  Leu Phe Lys Asp Ile  Leu Asp Lys Ile Glu  Leu Ile Gly 
    1295                 1300                 1305             


Asn Glu  Thr His Gly Leu Tyr  Leu Ala Asp Gln Tyr  Val Lys Gly 
    1310                 1315                 1320             


Ile Ala  Lys Ser Arg Lys Ser  Gly Ser 
    1325                 1330         


<210> 300
<211> 1332
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 300
Ser Ser Gln Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala 
1               5                   10                  15      


Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe 
            20                  25                  30          


Arg Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe 
        35                  40                  45              


Ser Asn Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly 
    50                  55                  60                  


Thr Lys Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr 
65                  70                  75                  80  


Phe Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly 
                85                  90                  95      


Thr Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala 
            100                 105                 110         


Thr Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro 
        115                 120                 125             


Phe Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser 
    130                 135                 140                 


Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val 
145                 150                 155                 160 


Ser Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys 
                165                 170                 175     


Asn Leu Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile 
            180                 185                 190         


Tyr Ser Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly 
        195                 200                 205             


Phe Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile 
    210                 215                 220                 


Thr Arg Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro 
225                 230                 235                 240 


Gly Asp Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val 
                245                 250                 255     


Gly Tyr Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly 
            260                 265                 270         


Thr Ile Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr 
        275                 280                 285             


Lys Cys Thr Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr 
    290                 295                 300                 


Ser Asn Phe Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn 
305                 310                 315                 320 


Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe 
                325                 330                 335     


Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala 
            340                 345                 350         


Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys 
        355                 360                 365             


Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val 
    370                 375                 380                 


Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala 
385                 390                 395                 400 


Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp 
                405                 410                 415     


Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser 
            420                 425                 430         


Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser 
        435                 440                 445             


Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala 
    450                 455                 460                 


Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro 
465                 470                 475                 480 


Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro 
                485                 490                 495     


Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr 
            500                 505                 510         


Val Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val 
        515                 520                 525             


Asn Phe Asn Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser 
    530                 535                 540                 


Asn Lys Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp 
545                 550                 555                 560 


Thr Thr Asp Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile 
                565                 570                 575     


Thr Pro Cys Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn 
            580                 585                 590         


Thr Ser Asn Gln Val Ala Val Leu Tyr Gln Gly Val Asn Cys Thr Glu 
        595                 600                 605             


Val Pro Val Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val 
    610                 615                 620                 


Tyr Ser Thr Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile 
625                 630                 635                 640 


Gly Ala Glu His Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly 
                645                 650                 655     


Ala Gly Ile Cys Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro Gly Ser 
            660                 665                 670         


Ala Ser Ser Val Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu 
        675                 680                 685             


Gly Ala Glu Asn Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro 
    690                 695                 700                 


Thr Asn Phe Thr Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met 
705                 710                 715                 720 


Thr Lys Thr Ser Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr 
                725                 730                 735     


Glu Cys Ser Asn Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu 
            740                 745                 750         


Asn Arg Ala Leu Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln 
        755                 760                 765             


Glu Val Phe Ala Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys 
    770                 775                 780                 


Asp Phe Gly Gly Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys 
785                 790                 795                 800 


Pro Ser Lys Arg Ser Pro Ile Glu Asp Leu Leu Phe Asn Lys Val Thr 
                805                 810                 815     


Leu Ala Asp Ala Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp 
            820                 825                 830         


Ile Ala Ala Arg Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr 
        835                 840                 845             


Val Leu Pro Pro Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser 
    850                 855                 860                 


Ala Leu Leu Ala Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly 
865                 870                 875                 880 


Pro Ala Leu Gln Ile Pro Phe Pro Met Gln Met Ala Tyr Arg Phe Asn 
                885                 890                 895     


Gly Ile Gly Val Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile 
            900                 905                 910         


Ala Asn Gln Phe Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser 
        915                 920                 925             


Ser Thr Pro Ser Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn 
    930                 935                 940                 


Ala Gln Ala Leu Asn Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly 
945                 950                 955                 960 


Ala Ile Ser Ser Val Leu Asn Asp Ile Leu Ser Arg Leu Asp Pro Pro 
                965                 970                 975     


Glu Ala Glu Val Gln Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser 
            980                 985                 990         


Leu Gln Thr Tyr Val Thr Gln Gln  Leu Ile Arg Ala Ala  Glu Ile Arg 
        995                 1000                 1005             


Ala Ser  Ala Asn Leu Ala Ala  Thr Lys Met Ser Glu  Cys Val Leu 
    1010                 1015                 1020             


Gly Gln  Ser Lys Arg Val Asp  Phe Cys Gly Lys Gly  Tyr His Leu 
    1025                 1030                 1035             


Met Ser  Phe Pro Gln Ser Ala  Pro His Gly Val Val  Phe Leu His 
    1040                 1045                 1050             


Val Thr  Tyr Val Pro Ala Gln  Glu Lys Asn Phe Thr  Thr Ala Pro 
    1055                 1060                 1065             


Ala Ile  Cys His Asp Gly Lys  Ala His Phe Pro Arg  Glu Gly Val 
    1070                 1075                 1080             


Phe Val  Ser Asn Gly Thr His  Trp Phe Val Thr Gln  Arg Asn Phe 
    1085                 1090                 1095             


Tyr Glu  Pro Gln Ile Ile Thr  Thr Asp Asn Thr Phe  Val Ser Gly 
    1100                 1105                 1110             


Asn Cys  Asp Val Val Ile Gly  Ile Val Asn Asn Thr  Val Tyr Asp 
    1115                 1120                 1125             


Pro Leu  Gln Ser Glu Leu Asp  Ser Ile Lys Glu Glu  Leu Asp Lys 
    1130                 1135                 1140             


Ile His  Lys Asn Leu Asp Ser  Ile Lys Glu Glu Leu  Asp Lys Ile 
    1145                 1150                 1155             


His Lys  Asn Gly Ser Gly Gly  Ser Gly Asp Ile Ile  Lys Leu Leu 
    1160                 1165                 1170             


Asn Glu  Gln Val Asn Lys Glu  Met Gln Ser Ser Asn  Leu Tyr Met 
    1175                 1180                 1185             


Ser Met  Ser Ser Trp Cys Tyr  Thr His Ser Leu Asp  Gly Ala Gly 
    1190                 1195                 1200             


Leu Phe  Leu Phe Asp His Ala  Ala Glu Glu Tyr Glu  His Ala Lys 
    1205                 1210                 1215             


Lys Leu  Ile Ile Phe Leu Asn  Glu Asn Asn Val Pro  Val Gln Leu 
    1220                 1225                 1230             


Thr Ser  Ile Ser Ala Pro Asn  His Ser Phe Glu Gly  Leu Thr Gln 
    1235                 1240                 1245             


Ile Phe  Gln Lys Ala Tyr Glu  His Glu Gln His Ile  Ser Glu Ser 
    1250                 1255                 1260             


Ile Asn  Asn Ile Val Asp His  Ala Ile Lys Ser Lys  Asp His Ala 
    1265                 1270                 1275             


Thr Phe  Asn Phe Leu Gln Trp  Tyr Val Ala Glu Gln  His Glu Glu 
    1280                 1285                 1290             


Glu Val  Leu Phe Lys Asp Ile  Leu Asp Lys Ile Glu  Leu Ile Gly 
    1295                 1300                 1305             


Asn Glu  Asn His Gly Leu Tyr  Leu Ala Asp Gln Tyr  Val Lys Gly 
    1310                 1315                 1320             


Ile Ala  Lys Ser Arg Lys Ser  Gly Ser 
    1325                 1330         


<210> 301
<211> 1336
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 301
His His His His His His His His Gly Pro Leu Glu Val Leu Phe Gln 
1               5                   10                  15      


Gly Pro Ser Ser Gln Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro 
            20                  25                  30          


Pro Ala Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys 
        35                  40                  45              


Val Phe Arg Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro 
    50                  55                  60                  


Phe Phe Ser Asn Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr 
65                  70                  75                  80  


Asn Gly Thr Lys Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly 
                85                  90                  95      


Val Tyr Phe Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile 
            100                 105                 110         


Phe Gly Thr Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn 
        115                 120                 125             


Asn Ala Thr Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn 
    130                 135                 140                 


Asp Pro Phe Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met 
145                 150                 155                 160 


Glu Ser Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu 
                165                 170                 175     


Tyr Val Ser Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn 
            180                 185                 190         


Phe Lys Asn Leu Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe 
        195                 200                 205             


Lys Ile Tyr Ser Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro 
    210                 215                 220                 


Gln Gly Phe Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile 
225                 230                 235                 240 


Asn Ile Thr Arg Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu 
                245                 250                 255     


Thr Pro Gly Asp Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr 
            260                 265                 270         


Tyr Val Gly Tyr Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu 
        275                 280                 285             


Asn Gly Thr Ile Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser 
    290                 295                 300                 


Glu Thr Lys Cys Thr Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr 
305                 310                 315                 320 


Gln Thr Ser Asn Phe Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe 
                325                 330                 335     


Pro Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr 
            340                 345                 350         


Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys 
        355                 360                 365             


Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe 
    370                 375                 380                 


Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr 
385                 390                 395                 400 


Asn Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln 
                405                 410                 415     


Ile Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu 
            420                 425                 430         


Pro Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu 
        435                 440                 445             


Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg 
    450                 455                 460                 


Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr 
465                 470                 475                 480 


Gln Ala Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr 
                485                 490                 495     


Phe Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr 
            500                 505                 510         


Gln Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro 
        515                 520                 525             


Ala Thr Val Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys 
    530                 535                 540                 


Cys Val Asn Phe Asn Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr 
545                 550                 555                 560 


Glu Ser Asn Lys Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile 
                565                 570                 575     


Ala Asp Thr Thr Asp Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu 
            580                 585                 590         


Asp Ile Thr Pro Cys Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly 
        595                 600                 605             


Thr Asn Thr Ser Asn Gln Val Ala Val Leu Tyr Gln Asp Val Asn Cys 
    610                 615                 620                 


Thr Glu Val Pro Val Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp 
625                 630                 635                 640 


Arg Val Tyr Ser Thr Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys 
                645                 650                 655     


Leu Ile Gly Ala Glu His Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro 
            660                 665                 670         


Ile Gly Ala Gly Ile Cys Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro 
        675                 680                 685             


Gly Ser Ala Ser Ser Val Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met 
    690                 695                 700                 


Ser Leu Gly Ala Glu Asn Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala 
705                 710                 715                 720 


Ile Pro Thr Asn Phe Thr Ile Ser Val Thr Thr Glu Ile Leu Pro Val 
                725                 730                 735     


Ser Met Thr Lys Thr Ser Val Asp Cys Thr Met Tyr Ile Cys Gly Asp 
            740                 745                 750         


Ser Thr Glu Cys Ser Asn Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr 
        755                 760                 765             


Gln Leu Asn Arg Ala Leu Thr Gly Ile Ala Val Glu Gln Asp Lys Asn 
    770                 775                 780                 


Thr Gln Glu Val Phe Ala Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro 
785                 790                 795                 800 


Ile Lys Asp Phe Gly Gly Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro 
                805                 810                 815     


Ser Lys Pro Ser Lys Arg Ser Phe Ile Glu Asp Leu Leu Phe Asn Lys 
            820                 825                 830         


Val Thr Leu Ala Asp Ala Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu 
        835                 840                 845             


Gly Asp Ile Ala Ala Arg Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly 
    850                 855                 860                 


Leu Thr Val Leu Pro Pro Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr 
865                 870                 875                 880 


Thr Ser Ala Leu Leu Ala Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly 
                885                 890                 895     


Ala Gly Ala Ala Leu Gln Ile Pro Phe Ala Met Gln Met Ala Tyr Arg 
            900                 905                 910         


Phe Asn Gly Ile Gly Val Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys 
        915                 920                 925             


Leu Ile Ala Asn Gln Phe Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser 
    930                 935                 940                 


Leu Ser Ser Thr Ala Ser Ala Leu Gly Lys Leu Gln Asp Val Val Asn 
945                 950                 955                 960 


Gln Asn Ala Gln Ala Leu Asn Thr Leu Val Lys Gln Leu Ser Ser Asn 
                965                 970                 975     


Phe Gly Ala Ile Ser Ser Val Leu Asn Asp Ile Leu Ser Arg Leu Asp 
            980                 985                 990         


Pro Pro Glu Ala Glu Val Gln Ile  Asp Arg Leu Ile Thr  Gly Arg Leu 
        995                 1000                 1005             


Gln Ser  Leu Gln Thr Tyr Val  Thr Gln Gln Leu Ile  Arg Ala Ala 
    1010                 1015                 1020             


Glu Ile  Arg Ala Ser Ala Asn  Leu Ala Ala Thr Lys  Met Ser Glu 
    1025                 1030                 1035             


Cys Val  Leu Gly Gln Ser Lys  Arg Val Asp Phe Cys  Gly Lys Gly 
    1040                 1045                 1050             


Tyr His  Leu Met Ser Phe Pro  Gln Ser Ala Pro His  Gly Val Val 
    1055                 1060                 1065             


Phe Leu  His Val Thr Tyr Val  Pro Ala Gln Glu Lys  Asn Phe Thr 
    1070                 1075                 1080             


Thr Ala  Pro Ala Ile Cys His  Asp Gly Lys Ala His  Phe Pro Arg 
    1085                 1090                 1095             


Glu Gly  Val Phe Val Ser Asn  Gly Thr His Trp Phe  Val Thr Gln 
    1100                 1105                 1110             


Arg Asn  Phe Tyr Glu Pro Gln  Ile Ile Thr Thr Asp  Asn Thr Phe 
    1115                 1120                 1125             


Val Ser  Gly Asn Cys Asp Val  Val Ile Gly Ile Val  Asn Asn Thr 
    1130                 1135                 1140             


Val Tyr  Asp Pro Leu Gln Ser  Glu Leu Asp Ser Ile  Lys Glu Glu 
    1145                 1150                 1155             


Leu Asp  Lys Ile His Lys Asn  Gly Ser Gly Gly Ser  Gly Asp Ile 
    1160                 1165                 1170             


Ile Lys  Leu Leu Asn Glu Gln  Val Asn Lys Glu Met  Gln Ser Ser 
    1175                 1180                 1185             


Asn Leu  Tyr Met Ser Met Ser  Ser Trp Cys Tyr Thr  His Ser Leu 
    1190                 1195                 1200             


Asp Gly  Ala Gly Leu Phe Leu  Phe Asp His Ala Ala  Glu Glu Tyr 
    1205                 1210                 1215             


Glu His  Ala Lys Lys Leu Ile  Ile Phe Leu Asn Glu  Asn Asn Val 
    1220                 1225                 1230             


Pro Val  Gln Leu Thr Ser Ile  Ser Ala Pro Glu His  Lys Phe Glu 
    1235                 1240                 1245             


Gly Leu  Thr Gln Ile Phe Gln  Lys Ala Tyr Glu His  Glu Gln His 
    1250                 1255                 1260             


Ile Ser  Glu Ser Ile Asn Asn  Ile Val Asp His Ala  Ile Lys Ser 
    1265                 1270                 1275             


Lys Asp  His Ala Thr Phe Asn  Phe Leu Gln Trp Tyr  Val Ala Glu 
    1280                 1285                 1290             


Gln His  Glu Glu Glu Val Leu  Phe Lys Asp Ile Leu  Asp Lys Ile 
    1295                 1300                 1305             


Glu Leu  Ile Gly Asn Glu Asn  His Gly Leu Tyr Leu  Ala Asp Gln 
    1310                 1315                 1320             


Tyr Val  Lys Gly Ile Ala Lys  Ser Arg Lys Ser Gly  Ser 
    1325                 1330                 1335     


<210> 302
<211> 1216
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 302
Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg 
1               5                   10                  15      


Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val 
            20                  25                  30          


Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys 
        35                  40                  45              


Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn 
    50                  55                  60                  


Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile 
65                  70                  75                  80  


Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro 
                85                  90                  95      


Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp 
            100                 105                 110         


Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys 
        115                 120                 125             


Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln 
    130                 135                 140                 


Ala Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe 
145                 150                 155                 160 


Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln 
                165                 170                 175     


Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala 
            180                 185                 190         


Thr Val Cys Gly Gly Gly Gly Ser Thr Asn Leu Cys Pro Phe Gly Glu 
        195                 200                 205             


Val Phe Asn Ala Thr Lys Phe Pro Ser Val Tyr Ala Trp Glu Arg Lys 
    210                 215                 220                 


Lys Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser Thr 
225                 230                 235                 240 


Phe Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Ala Thr Lys Leu Asn 
                245                 250                 255     


Asp Leu Cys Phe Ser Asn Val Tyr Ala Asp Ser Phe Val Val Lys Gly 
            260                 265                 270         


Asp Asp Val Arg Gln Ile Ala Pro Gly Gln Thr Gly Val Ile Ala Asp 
        275                 280                 285             


Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Met Gly Cys Val Leu Ala Trp 
    290                 295                 300                 


Asn Thr Arg Asn Ile Asp Ala Thr Ser Thr Gly Asn Tyr Asn Tyr Lys 
305                 310                 315                 320 


Tyr Arg Tyr Leu Arg His Gly Lys Leu Arg Pro Phe Glu Arg Asp Ile 
                325                 330                 335     


Ser Asn Val Pro Phe Ser Pro Asp Gly Lys Pro Cys Thr Pro Pro Ala 
            340                 345                 350         


Leu Asn Cys Tyr Trp Pro Leu Asn Asp Tyr Gly Phe Tyr Thr Thr Thr 
        355                 360                 365             


Gly Ile Gly Tyr Gln Pro Cys Gly Gly Gly Gly Ser Asp Cys Asp Ile 
    370                 375                 380                 


Asp Lys Trp Leu Asn Asn Phe Asn Val Pro Ser Pro Leu Asn Trp Glu 
385                 390                 395                 400 


Arg Lys Ile Phe Ser Asn Cys Asn Phe Asn Leu Ser Thr Leu Leu Arg 
                405                 410                 415     


Leu Val His Thr Asp Ser Phe Ser Cys Asn Asn Phe Asp Glu Ser Lys 
            420                 425                 430         


Ile Tyr Gly Ser Cys Phe Lys Ser Ile Val Leu Asp Lys Phe Ala Ile 
        435                 440                 445             


Pro Asn Ser Arg Arg Ser Asp Leu Gln Leu Gly Ser Ser Gly Phe Leu 
    450                 455                 460                 


Gln Ser Ser Asn Tyr Lys Ile Asp Thr Thr Ser Ser Ser Cys Gln Leu 
465                 470                 475                 480 


Tyr Tyr Ser Leu Pro Ala Ile Asn Val Thr Ile Asn Asn Tyr Asn Pro 
                485                 490                 495     


Ser Ser Trp Asn Arg Arg Tyr Gly Phe Asn Asn Phe Asn Leu Ser Ser 
            500                 505                 510         


His Ser Val Val Tyr Ser Arg Tyr Cys Phe Ser Val Asn Asn Thr Phe 
        515                 520                 525             


Cys Pro Cys Ala Lys Pro Ser Phe Ala Ser Ser Cys Lys Ser His Lys 
    530                 535                 540                 


Pro Pro Ser Ala Ser Cys Pro Ile Gly Thr Asn Tyr Arg Ser Cys Glu 
545                 550                 555                 560 


Ser Thr Thr Val Leu Asp His Thr Asp Trp Cys Arg Cys Ser Cys Leu 
                565                 570                 575     


Pro Asp Pro Ile Thr Ala Tyr Asp Pro Arg Ser Cys Ser Gln Lys Lys 
            580                 585                 590         


Ser Leu Val Gly Val Gly Glu His Cys Ala Gly Phe Gly Val Asp Glu 
        595                 600                 605             


Glu Lys Cys Gly Val Leu Asp Gly Ser Tyr Asn Val Ser Cys Leu Cys 
    610                 615                 620                 


Ser Thr Asp Ala Phe Leu Gly Trp Ser Tyr Asp Thr Cys Val Ser Asn 
625                 630                 635                 640 


Asn Arg Cys Asn Ile Phe Ser Asn Phe Ile Leu Asn Gly Cys Gly Gly 
                645                 650                 655     


Gly Gly Ser Glu Ala Lys Pro Ser Gly Ser Val Val Glu Gln Ala Glu 
            660                 665                 670         


Gly Val Glu Cys Asp Phe Ser Pro Leu Leu Ser Gly Thr Pro Pro Gln 
        675                 680                 685             


Val Tyr Asn Phe Lys Arg Leu Val Phe Thr Asn Cys Asn Tyr Asn Leu 
    690                 695                 700                 


Thr Lys Leu Leu Ser Leu Phe Ser Val Asn Asp Phe Thr Cys Ser Gln 
705                 710                 715                 720 


Ile Ser Pro Ala Ala Ile Ala Ser Asn Cys Tyr Ser Ser Leu Ile Leu 
                725                 730                 735     


Asp Tyr Phe Ser Tyr Pro Leu Ser Met Lys Ser Asp Leu Ser Val Ser 
            740                 745                 750         


Ser Ala Gly Pro Ile Ser Gln Phe Asn Tyr Lys Gln Ser Phe Ser Asn 
        755                 760                 765             


Pro Thr Cys Leu Ile Leu Ala Thr Val Pro His Asn Leu Thr Thr Ile 
    770                 775                 780                 


Thr Lys Pro Leu Lys Tyr Ser Tyr Ile Asn Lys Cys Ser Arg Phe Leu 
785                 790                 795                 800 


Ser Asp Asp Arg Thr Glu Val Pro Gln Leu Val Asn Ala Asn Gln Tyr 
                805                 810                 815     


Ser Pro Cys Val Ser Ile Val Pro Ser Thr Val Trp Glu Asp Gly Asp 
            820                 825                 830         


Tyr Tyr Arg Lys Gln Leu Ser Pro Leu Glu Gly Gly Gly Trp Leu Val 
        835                 840                 845             


Ala Ser Gly Ser Thr Val Ala Met Thr Glu Gln Leu Gln Met Gly Phe 
    850                 855                 860                 


Gly Ile Thr Val Gln Tyr Gly Thr Asp Thr Asn Ser Val Cys Pro Lys 
865                 870                 875                 880 


Cys Gly Gly Gly Gly Ser Ser Ile Val Ser Leu Pro Val Tyr His Lys 
                885                 890                 895     


His Thr Phe Ile Val Leu Tyr Val Asp Phe Lys Pro Gln Ser Gly Gly 
            900                 905                 910         


Gly Lys Cys Phe Asn Cys Tyr Pro Ala Gly Val Asn Ile Thr Leu Ala 
        915                 920                 925             


Asn Phe Asn Glu Thr Lys Gly Pro Leu Cys Val Asp Thr Ser His Phe 
    930                 935                 940                 


Thr Thr Lys Tyr Val Ala Val Tyr Ala Asn Val Gly Arg Trp Ser Ala 
945                 950                 955                 960 


Ser Ile Asn Thr Gly Asn Cys Pro Phe Ser Phe Gly Lys Val Asn Asn 
                965                 970                 975     


Phe Val Lys Phe Gly Ser Val Cys Phe Ser Leu Lys Asp Ile Pro Gly 
            980                 985                 990         


Gly Cys Ala Met Pro Ile Val Ala  Asn Trp Ala Tyr Ser  Lys Tyr Tyr 
        995                 1000                 1005             


Thr Ile  Gly Ser Leu Tyr Val  Ser Trp Ser Asp Gly  Asp Gly Ile 
    1010                 1015                 1020             


Thr Gly  Val Pro Gln Pro Val  Glu Gly Val Ser Ser  Gly Ser Gly 
    1025                 1030                 1035             


Gly Gly  Gly Glu Ser Gln Val  Arg Gln Gln Phe Ser  Lys Asp Ile 
    1040                 1045                 1050             


Glu Lys  Leu Leu Asn Glu Gln  Val Asn Lys Glu Met  Gln Ser Ser 
    1055                 1060                 1065             


Asn Leu  Tyr Met Ser Met Ser  Ser Trp Cys Tyr Thr  His Ser Leu 
    1070                 1075                 1080             


Asp Gly  Ala Gly Leu Phe Leu  Phe Asp His Ala Ala  Glu Glu Tyr 
    1085                 1090                 1095             


Glu His  Ala Lys Lys Leu Ile  Ile Phe Leu Asn Glu  Asn Asn Val 
    1100                 1105                 1110             


Pro Val  Gln Leu Thr Ser Ile  Ser Ala Pro Glu His  Lys Phe Glu 
    1115                 1120                 1125             


Gly Leu  Thr Gln Ile Phe Gln  Lys Ala Tyr Glu His  Glu Gln His 
    1130                 1135                 1140             


Ile Ser  Glu Ser Ile Asn Asn  Ile Val Asp His Ala  Ile Lys Ser 
    1145                 1150                 1155             


Lys Asp  His Ala Thr Phe Asn  Phe Leu Gln Trp Tyr  Val Ala Glu 
    1160                 1165                 1170             


Gln His  Glu Glu Glu Val Leu  Phe Lys Asp Ile Leu  Asp Lys Ile 
    1175                 1180                 1185             


Glu Leu  Ile Gly Asn Glu Asn  His Gly Leu Tyr Leu  Ala Asp Gln 
    1190                 1195                 1200             


Tyr Val  Lys Gly Ile Ala Lys  Ser Arg Lys Ser Gly  Ser 
    1205                 1210                 1215     


<210> 303
<211> 1216
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 303
Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Lys Phe Pro 
1               5                   10                  15      


Ser Val Tyr Ala Trp Glu Arg Lys Lys Ile Ser Asn Cys Val Ala Asp 
            20                  25                  30          


Tyr Ser Val Leu Tyr Asn Ser Thr Phe Phe Ser Thr Phe Lys Cys Tyr 
        35                  40                  45              


Gly Val Ser Ala Thr Lys Leu Asn Asp Leu Cys Phe Ser Asn Val Tyr 
    50                  55                  60                  


Ala Asp Ser Phe Val Val Lys Gly Asp Asp Val Arg Gln Ile Ala Pro 
65                  70                  75                  80  


Gly Gln Thr Gly Val Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp 
                85                  90                  95      


Phe Met Gly Cys Val Leu Ala Trp Asn Thr Arg Asn Ile Asp Ala Thr 
            100                 105                 110         


Ser Thr Gly Asn Tyr Asn Tyr Lys Tyr Arg Tyr Leu Arg His Gly Lys 
        115                 120                 125             


Leu Arg Pro Phe Glu Arg Asp Ile Ser Asn Val Pro Phe Ser Pro Asp 
    130                 135                 140                 


Gly Lys Pro Cys Thr Pro Pro Ala Leu Asn Cys Tyr Trp Pro Leu Asn 
145                 150                 155                 160 


Asp Tyr Gly Phe Tyr Thr Thr Thr Gly Ile Gly Tyr Gln Pro Cys Gly 
                165                 170                 175     


Gly Gly Gly Ser Asp Cys Asp Ile Asp Lys Trp Leu Asn Asn Phe Asn 
            180                 185                 190         


Val Pro Ser Pro Leu Asn Trp Glu Arg Lys Ile Phe Ser Asn Cys Asn 
        195                 200                 205             


Phe Asn Leu Ser Thr Leu Leu Arg Leu Val His Thr Asp Ser Phe Ser 
    210                 215                 220                 


Cys Asn Asn Phe Asp Glu Ser Lys Ile Tyr Gly Ser Cys Phe Lys Ser 
225                 230                 235                 240 


Ile Val Leu Asp Lys Phe Ala Ile Pro Asn Ser Arg Arg Ser Asp Leu 
                245                 250                 255     


Gln Leu Gly Ser Ser Gly Phe Leu Gln Ser Ser Asn Tyr Lys Ile Asp 
            260                 265                 270         


Thr Thr Ser Ser Ser Cys Gln Leu Tyr Tyr Ser Leu Pro Ala Ile Asn 
        275                 280                 285             


Val Thr Ile Asn Asn Tyr Asn Pro Ser Ser Trp Asn Arg Arg Tyr Gly 
    290                 295                 300                 


Phe Asn Asn Phe Asn Leu Ser Ser His Ser Val Val Tyr Ser Arg Tyr 
305                 310                 315                 320 


Cys Phe Ser Val Asn Asn Thr Phe Cys Pro Cys Ala Lys Pro Ser Phe 
                325                 330                 335     


Ala Ser Ser Cys Lys Ser His Lys Pro Pro Ser Ala Ser Cys Pro Ile 
            340                 345                 350         


Gly Thr Asn Tyr Arg Ser Cys Glu Ser Thr Thr Val Leu Asp His Thr 
        355                 360                 365             


Asp Trp Cys Arg Cys Ser Cys Leu Pro Asp Pro Ile Thr Ala Tyr Asp 
    370                 375                 380                 


Pro Arg Ser Cys Ser Gln Lys Lys Ser Leu Val Gly Val Gly Glu His 
385                 390                 395                 400 


Cys Ala Gly Phe Gly Val Asp Glu Glu Lys Cys Gly Val Leu Asp Gly 
                405                 410                 415     


Ser Tyr Asn Val Ser Cys Leu Cys Ser Thr Asp Ala Phe Leu Gly Trp 
            420                 425                 430         


Ser Tyr Asp Thr Cys Val Ser Asn Asn Arg Cys Asn Ile Phe Ser Asn 
        435                 440                 445             


Phe Ile Leu Asn Gly Cys Gly Gly Gly Gly Ser Glu Ala Lys Pro Ser 
    450                 455                 460                 


Gly Ser Val Val Glu Gln Ala Glu Gly Val Glu Cys Asp Phe Ser Pro 
465                 470                 475                 480 


Leu Leu Ser Gly Thr Pro Pro Gln Val Tyr Asn Phe Lys Arg Leu Val 
                485                 490                 495     


Phe Thr Asn Cys Asn Tyr Asn Leu Thr Lys Leu Leu Ser Leu Phe Ser 
            500                 505                 510         


Val Asn Asp Phe Thr Cys Ser Gln Ile Ser Pro Ala Ala Ile Ala Ser 
        515                 520                 525             


Asn Cys Tyr Ser Ser Leu Ile Leu Asp Tyr Phe Ser Tyr Pro Leu Ser 
    530                 535                 540                 


Met Lys Ser Asp Leu Ser Val Ser Ser Ala Gly Pro Ile Ser Gln Phe 
545                 550                 555                 560 


Asn Tyr Lys Gln Ser Phe Ser Asn Pro Thr Cys Leu Ile Leu Ala Thr 
                565                 570                 575     


Val Pro His Asn Leu Thr Thr Ile Thr Lys Pro Leu Lys Tyr Ser Tyr 
            580                 585                 590         


Ile Asn Lys Cys Ser Arg Phe Leu Ser Asp Asp Arg Thr Glu Val Pro 
        595                 600                 605             


Gln Leu Val Asn Ala Asn Gln Tyr Ser Pro Cys Val Ser Ile Val Pro 
    610                 615                 620                 


Ser Thr Val Trp Glu Asp Gly Asp Tyr Tyr Arg Lys Gln Leu Ser Pro 
625                 630                 635                 640 


Leu Glu Gly Gly Gly Trp Leu Val Ala Ser Gly Ser Thr Val Ala Met 
                645                 650                 655     


Thr Glu Gln Leu Gln Met Gly Phe Gly Ile Thr Val Gln Tyr Gly Thr 
            660                 665                 670         


Asp Thr Asn Ser Val Cys Pro Lys Cys Gly Gly Gly Gly Ser Ser Ile 
        675                 680                 685             


Val Ser Leu Pro Val Tyr His Lys His Thr Phe Ile Val Leu Tyr Val 
    690                 695                 700                 


Asp Phe Lys Pro Gln Ser Gly Gly Gly Lys Cys Phe Asn Cys Tyr Pro 
705                 710                 715                 720 


Ala Gly Val Asn Ile Thr Leu Ala Asn Phe Asn Glu Thr Lys Gly Pro 
                725                 730                 735     


Leu Cys Val Asp Thr Ser His Phe Thr Thr Lys Tyr Val Ala Val Tyr 
            740                 745                 750         


Ala Asn Val Gly Arg Trp Ser Ala Ser Ile Asn Thr Gly Asn Cys Pro 
        755                 760                 765             


Phe Ser Phe Gly Lys Val Asn Asn Phe Val Lys Phe Gly Ser Val Cys 
    770                 775                 780                 


Phe Ser Leu Lys Asp Ile Pro Gly Gly Cys Ala Met Pro Ile Val Ala 
785                 790                 795                 800 


Asn Trp Ala Tyr Ser Lys Tyr Tyr Thr Ile Gly Ser Leu Tyr Val Ser 
                805                 810                 815     


Trp Ser Asp Gly Asp Gly Ile Thr Gly Val Pro Gln Pro Val Glu Gly 
            820                 825                 830         


Val Ser Ser Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn 
        835                 840                 845             


Ala Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser 
    850                 855                 860                 


Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser 
865                 870                 875                 880 


Thr Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys 
                885                 890                 895     


Phe Thr Asn Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val 
            900                 905                 910         


Arg Gln Ile Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr 
        915                 920                 925             


Lys Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn 
    930                 935                 940                 


Asn Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu 
945                 950                 955                 960 


Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu 
                965                 970                 975     


Ile Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn 
            980                 985                 990         


Cys Tyr Phe Pro Leu Gln Ser Tyr  Gly Phe Gln Pro Thr  Asn Gly Val 
        995                 1000                 1005             


Gly Tyr  Gln Pro Tyr Arg Val  Val Val Leu Ser Phe  Glu Leu Leu 
    1010                 1015                 1020             


His Ala  Pro Ala Thr Val Cys  Gly Gly Gly Gly Ser  Gly Ser Gly 
    1025                 1030                 1035             


Gly Gly  Gly Glu Ser Gln Val  Arg Gln Gln Phe Ser  Lys Asp Ile 
    1040                 1045                 1050             


Glu Lys  Leu Leu Asn Glu Gln  Val Asn Lys Glu Met  Gln Ser Ser 
    1055                 1060                 1065             


Asn Leu  Tyr Met Ser Met Ser  Ser Trp Cys Tyr Thr  His Ser Leu 
    1070                 1075                 1080             


Asp Gly  Ala Gly Leu Phe Leu  Phe Asp His Ala Ala  Glu Glu Tyr 
    1085                 1090                 1095             


Glu His  Ala Lys Lys Leu Ile  Ile Phe Leu Asn Glu  Asn Asn Val 
    1100                 1105                 1110             


Pro Val  Gln Leu Thr Ser Ile  Ser Ala Pro Glu His  Lys Phe Glu 
    1115                 1120                 1125             


Gly Leu  Thr Gln Ile Phe Gln  Lys Ala Tyr Glu His  Glu Gln His 
    1130                 1135                 1140             


Ile Ser  Glu Ser Ile Asn Asn  Ile Val Asp His Ala  Ile Lys Ser 
    1145                 1150                 1155             


Lys Asp  His Ala Thr Phe Asn  Phe Leu Gln Trp Tyr  Val Ala Glu 
    1160                 1165                 1170             


Gln His  Glu Glu Glu Val Leu  Phe Lys Asp Ile Leu  Asp Lys Ile 
    1175                 1180                 1185             


Glu Leu  Ile Gly Asn Glu Asn  His Gly Leu Tyr Leu  Ala Asp Gln 
    1190                 1195                 1200             


Tyr Val  Lys Gly Ile Ala Lys  Ser Arg Lys Ser Gly  Ser 
    1205                 1210                 1215     


<210> 304
<211> 937
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 304
Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg 
1               5                   10                  15      


Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val 
            20                  25                  30          


Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys 
        35                  40                  45              


Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn 
    50                  55                  60                  


Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile 
65                  70                  75                  80  


Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro 
                85                  90                  95      


Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp 
            100                 105                 110         


Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys 
        115                 120                 125             


Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln 
    130                 135                 140                 


Ala Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe 
145                 150                 155                 160 


Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln 
                165                 170                 175     


Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala 
            180                 185                 190         


Thr Val Cys Gly Gly Gly Gly Ser Thr Asn Leu Cys Pro Phe Gly Glu 
        195                 200                 205             


Val Phe Asn Ala Thr Lys Phe Pro Ser Val Tyr Ala Trp Glu Arg Lys 
    210                 215                 220                 


Lys Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser Thr 
225                 230                 235                 240 


Phe Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Ala Thr Lys Leu Asn 
                245                 250                 255     


Asp Leu Cys Phe Ser Asn Val Tyr Ala Asp Ser Phe Val Val Lys Gly 
            260                 265                 270         


Asp Asp Val Arg Gln Ile Ala Pro Gly Gln Thr Gly Val Ile Ala Asp 
        275                 280                 285             


Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Met Gly Cys Val Leu Ala Trp 
    290                 295                 300                 


Asn Thr Arg Asn Ile Asp Ala Thr Ser Thr Gly Asn Tyr Asn Tyr Lys 
305                 310                 315                 320 


Tyr Arg Tyr Leu Arg His Gly Lys Leu Arg Pro Phe Glu Arg Asp Ile 
                325                 330                 335     


Ser Asn Val Pro Phe Ser Pro Asp Gly Lys Pro Cys Thr Pro Pro Ala 
            340                 345                 350         


Leu Asn Cys Tyr Trp Pro Leu Asn Asp Tyr Gly Phe Tyr Thr Thr Thr 
        355                 360                 365             


Gly Ile Gly Tyr Gln Pro Cys Gly Gly Gly Gly Ser Glu Ala Lys Pro 
    370                 375                 380                 


Ser Gly Ser Val Val Glu Gln Ala Glu Gly Val Glu Cys Asp Phe Ser 
385                 390                 395                 400 


Pro Leu Leu Ser Gly Thr Pro Pro Gln Val Tyr Asn Phe Lys Arg Leu 
                405                 410                 415     


Val Phe Thr Asn Cys Asn Tyr Asn Leu Thr Lys Leu Leu Ser Leu Phe 
            420                 425                 430         


Ser Val Asn Asp Phe Thr Cys Ser Gln Ile Ser Pro Ala Ala Ile Ala 
        435                 440                 445             


Ser Asn Cys Tyr Ser Ser Leu Ile Leu Asp Tyr Phe Ser Tyr Pro Leu 
    450                 455                 460                 


Ser Met Lys Ser Asp Leu Ser Val Ser Ser Ala Gly Pro Ile Ser Gln 
465                 470                 475                 480 


Phe Asn Tyr Lys Gln Ser Phe Ser Asn Pro Thr Cys Leu Ile Leu Ala 
                485                 490                 495     


Thr Val Pro His Asn Leu Thr Thr Ile Thr Lys Pro Leu Lys Tyr Ser 
            500                 505                 510         


Tyr Ile Asn Lys Cys Ser Arg Phe Leu Ser Asp Asp Arg Thr Glu Val 
        515                 520                 525             


Pro Gln Leu Val Asn Ala Asn Gln Tyr Ser Pro Cys Val Ser Ile Val 
    530                 535                 540                 


Pro Ser Thr Val Trp Glu Asp Gly Asp Tyr Tyr Arg Lys Gln Leu Ser 
545                 550                 555                 560 


Pro Leu Glu Gly Gly Gly Trp Leu Val Ala Ser Gly Ser Thr Val Ala 
                565                 570                 575     


Met Thr Glu Gln Leu Gln Met Gly Phe Gly Ile Thr Val Gln Tyr Gly 
            580                 585                 590         


Thr Asp Thr Asn Ser Val Cys Pro Lys Cys Gly Gly Gly Gly Ser Ser 
        595                 600                 605             


Ile Val Ser Leu Pro Val Tyr His Lys His Thr Phe Ile Val Leu Tyr 
    610                 615                 620                 


Val Asp Phe Lys Pro Gln Ser Gly Gly Gly Lys Cys Phe Asn Cys Tyr 
625                 630                 635                 640 


Pro Ala Gly Val Asn Ile Thr Leu Ala Asn Phe Asn Glu Thr Lys Gly 
                645                 650                 655     


Pro Leu Cys Val Asp Thr Ser His Phe Thr Thr Lys Tyr Val Ala Val 
            660                 665                 670         


Tyr Ala Asn Val Gly Arg Trp Ser Ala Ser Ile Asn Thr Gly Asn Cys 
        675                 680                 685             


Pro Phe Ser Phe Gly Lys Val Asn Asn Phe Val Lys Phe Gly Ser Val 
    690                 695                 700                 


Cys Phe Ser Leu Lys Asp Ile Pro Gly Gly Cys Ala Met Pro Ile Val 
705                 710                 715                 720 


Ala Asn Trp Ala Tyr Ser Lys Tyr Tyr Thr Ile Gly Ser Leu Tyr Val 
                725                 730                 735     


Ser Trp Ser Asp Gly Asp Gly Ile Thr Gly Val Pro Gln Pro Val Glu 
            740                 745                 750         


Gly Val Ser Ser Gly Ser Gly Gly Gly Gly Glu Ser Gln Val Arg Gln 
        755                 760                 765             


Gln Phe Ser Lys Asp Ile Glu Lys Leu Leu Asn Glu Gln Val Asn Lys 
    770                 775                 780                 


Glu Met Gln Ser Ser Asn Leu Tyr Met Ser Met Ser Ser Trp Cys Tyr 
785                 790                 795                 800 


Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp His Ala Ala 
                805                 810                 815     


Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe Leu Asn Glu Asn 
            820                 825                 830         


Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro Glu His Lys Phe 
        835                 840                 845             


Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu His Glu Gln His 
    850                 855                 860                 


Ile Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala Ile Lys Ser Lys 
865                 870                 875                 880 


Asp His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala Glu Gln His 
                885                 890                 895     


Glu Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys Ile Glu Leu Ile 
            900                 905                 910         


Gly Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr Val Lys Gly 
        915                 920                 925             


Ile Ala Lys Ser Arg Lys Ser Gly Ser 
    930                 935         


<210> 305
<211> 1036
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 305
Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg 
1               5                   10                  15      


Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val 
            20                  25                  30          


Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys 
        35                  40                  45              


Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn 
    50                  55                  60                  


Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile 
65                  70                  75                  80  


Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro 
                85                  90                  95      


Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp 
            100                 105                 110         


Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys 
        115                 120                 125             


Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln 
    130                 135                 140                 


Ala Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe 
145                 150                 155                 160 


Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln 
                165                 170                 175     


Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala 
            180                 185                 190         


Thr Val Cys Gly Gly Gly Gly Ser Asp Cys Asp Ile Asp Lys Trp Leu 
        195                 200                 205             


Asn Asn Phe Asn Val Pro Ser Pro Leu Asn Trp Glu Arg Lys Ile Phe 
    210                 215                 220                 


Ser Asn Cys Asn Phe Asn Leu Ser Thr Leu Leu Arg Leu Val His Thr 
225                 230                 235                 240 


Asp Ser Phe Ser Cys Asn Asn Phe Asp Glu Ser Lys Ile Tyr Gly Ser 
                245                 250                 255     


Cys Phe Lys Ser Ile Val Leu Asp Lys Phe Ala Ile Pro Asn Ser Arg 
            260                 265                 270         


Arg Ser Asp Leu Gln Leu Gly Ser Ser Gly Phe Leu Gln Ser Ser Asn 
        275                 280                 285             


Tyr Lys Ile Asp Thr Thr Ser Ser Ser Cys Gln Leu Tyr Tyr Ser Leu 
    290                 295                 300                 


Pro Ala Ile Asn Val Thr Ile Asn Asn Tyr Asn Pro Ser Ser Trp Asn 
305                 310                 315                 320 


Arg Arg Tyr Gly Phe Asn Asn Phe Asn Leu Ser Ser His Ser Val Val 
                325                 330                 335     


Tyr Ser Arg Tyr Cys Phe Ser Val Asn Asn Thr Phe Cys Pro Cys Ala 
            340                 345                 350         


Lys Pro Ser Phe Ala Ser Ser Cys Lys Ser His Lys Pro Pro Ser Ala 
        355                 360                 365             


Ser Cys Pro Ile Gly Thr Asn Tyr Arg Ser Cys Glu Ser Thr Thr Val 
    370                 375                 380                 


Leu Asp His Thr Asp Trp Cys Arg Cys Ser Cys Leu Pro Asp Pro Ile 
385                 390                 395                 400 


Thr Ala Tyr Asp Pro Arg Ser Cys Ser Gln Lys Lys Ser Leu Val Gly 
                405                 410                 415     


Val Gly Glu His Cys Ala Gly Phe Gly Val Asp Glu Glu Lys Cys Gly 
            420                 425                 430         


Val Leu Asp Gly Ser Tyr Asn Val Ser Cys Leu Cys Ser Thr Asp Ala 
        435                 440                 445             


Phe Leu Gly Trp Ser Tyr Asp Thr Cys Val Ser Asn Asn Arg Cys Asn 
    450                 455                 460                 


Ile Phe Ser Asn Phe Ile Leu Asn Gly Cys Gly Gly Gly Gly Ser Glu 
465                 470                 475                 480 


Ala Lys Pro Ser Gly Ser Val Val Glu Gln Ala Glu Gly Val Glu Cys 
                485                 490                 495     


Asp Phe Ser Pro Leu Leu Ser Gly Thr Pro Pro Gln Val Tyr Asn Phe 
            500                 505                 510         


Lys Arg Leu Val Phe Thr Asn Cys Asn Tyr Asn Leu Thr Lys Leu Leu 
        515                 520                 525             


Ser Leu Phe Ser Val Asn Asp Phe Thr Cys Ser Gln Ile Ser Pro Ala 
    530                 535                 540                 


Ala Ile Ala Ser Asn Cys Tyr Ser Ser Leu Ile Leu Asp Tyr Phe Ser 
545                 550                 555                 560 


Tyr Pro Leu Ser Met Lys Ser Asp Leu Ser Val Ser Ser Ala Gly Pro 
                565                 570                 575     


Ile Ser Gln Phe Asn Tyr Lys Gln Ser Phe Ser Asn Pro Thr Cys Leu 
            580                 585                 590         


Ile Leu Ala Thr Val Pro His Asn Leu Thr Thr Ile Thr Lys Pro Leu 
        595                 600                 605             


Lys Tyr Ser Tyr Ile Asn Lys Cys Ser Arg Phe Leu Ser Asp Asp Arg 
    610                 615                 620                 


Thr Glu Val Pro Gln Leu Val Asn Ala Asn Gln Tyr Ser Pro Cys Val 
625                 630                 635                 640 


Ser Ile Val Pro Ser Thr Val Trp Glu Asp Gly Asp Tyr Tyr Arg Lys 
                645                 650                 655     


Gln Leu Ser Pro Leu Glu Gly Gly Gly Trp Leu Val Ala Ser Gly Ser 
            660                 665                 670         


Thr Val Ala Met Thr Glu Gln Leu Gln Met Gly Phe Gly Ile Thr Val 
        675                 680                 685             


Gln Tyr Gly Thr Asp Thr Asn Ser Val Cys Pro Lys Cys Gly Gly Gly 
    690                 695                 700                 


Gly Ser Ser Ile Val Ser Leu Pro Val Tyr His Lys His Thr Phe Ile 
705                 710                 715                 720 


Val Leu Tyr Val Asp Phe Lys Pro Gln Ser Gly Gly Gly Lys Cys Phe 
                725                 730                 735     


Asn Cys Tyr Pro Ala Gly Val Asn Ile Thr Leu Ala Asn Phe Asn Glu 
            740                 745                 750         


Thr Lys Gly Pro Leu Cys Val Asp Thr Ser His Phe Thr Thr Lys Tyr 
        755                 760                 765             


Val Ala Val Tyr Ala Asn Val Gly Arg Trp Ser Ala Ser Ile Asn Thr 
    770                 775                 780                 


Gly Asn Cys Pro Phe Ser Phe Gly Lys Val Asn Asn Phe Val Lys Phe 
785                 790                 795                 800 


Gly Ser Val Cys Phe Ser Leu Lys Asp Ile Pro Gly Gly Cys Ala Met 
                805                 810                 815     


Pro Ile Val Ala Asn Trp Ala Tyr Ser Lys Tyr Tyr Thr Ile Gly Ser 
            820                 825                 830         


Leu Tyr Val Ser Trp Ser Asp Gly Asp Gly Ile Thr Gly Val Pro Gln 
        835                 840                 845             


Pro Val Glu Gly Val Ser Ser Gly Ser Gly Gly Gly Gly Glu Ser Gln 
    850                 855                 860                 


Val Arg Gln Gln Phe Ser Lys Asp Ile Glu Lys Leu Leu Asn Glu Gln 
865                 870                 875                 880 


Val Asn Lys Glu Met Gln Ser Ser Asn Leu Tyr Met Ser Met Ser Ser 
                885                 890                 895     


Trp Cys Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp 
            900                 905                 910         


His Ala Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe Leu 
        915                 920                 925             


Asn Glu Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro Glu 
    930                 935                 940                 


His Lys Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu His 
945                 950                 955                 960 


Glu Gln His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala Ile 
                965                 970                 975     


Lys Ser Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala 
            980                 985                 990         


Glu Gln His Glu Glu Glu Val Leu  Phe Lys Asp Ile Leu  Asp Lys Ile 
        995                 1000                 1005             


Glu Leu  Ile Gly Asn Glu Asn  His Gly Leu Tyr Leu  Ala Asp Gln 
    1010                 1015                 1020             


Tyr Val  Lys Gly Ile Ala Lys  Ser Arg Lys Ser Gly  Ser 
    1025                 1030                 1035     


<210> 306
<211> 989
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 306
Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg 
1               5                   10                  15      


Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val 
            20                  25                  30          


Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys 
        35                  40                  45              


Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn 
    50                  55                  60                  


Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile 
65                  70                  75                  80  


Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro 
                85                  90                  95      


Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp 
            100                 105                 110         


Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys 
        115                 120                 125             


Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln 
    130                 135                 140                 


Ala Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe 
145                 150                 155                 160 


Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln 
                165                 170                 175     


Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala 
            180                 185                 190         


Thr Val Cys Gly Gly Gly Gly Ser Thr Asn Leu Cys Pro Phe Gly Glu 
        195                 200                 205             


Val Phe Asn Ala Thr Lys Phe Pro Ser Val Tyr Ala Trp Glu Arg Lys 
    210                 215                 220                 


Lys Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser Thr 
225                 230                 235                 240 


Phe Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Ala Thr Lys Leu Asn 
                245                 250                 255     


Asp Leu Cys Phe Ser Asn Val Tyr Ala Asp Ser Phe Val Val Lys Gly 
            260                 265                 270         


Asp Asp Val Arg Gln Ile Ala Pro Gly Gln Thr Gly Val Ile Ala Asp 
        275                 280                 285             


Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Met Gly Cys Val Leu Ala Trp 
    290                 295                 300                 


Asn Thr Arg Asn Ile Asp Ala Thr Ser Thr Gly Asn Tyr Asn Tyr Lys 
305                 310                 315                 320 


Tyr Arg Tyr Leu Arg His Gly Lys Leu Arg Pro Phe Glu Arg Asp Ile 
                325                 330                 335     


Ser Asn Val Pro Phe Ser Pro Asp Gly Lys Pro Cys Thr Pro Pro Ala 
            340                 345                 350         


Leu Asn Cys Tyr Trp Pro Leu Asn Asp Tyr Gly Phe Tyr Thr Thr Thr 
        355                 360                 365             


Gly Ile Gly Tyr Gln Pro Cys Gly Gly Gly Gly Ser Asp Cys Asp Ile 
    370                 375                 380                 


Asp Lys Trp Leu Asn Asn Phe Asn Val Pro Ser Pro Leu Asn Trp Glu 
385                 390                 395                 400 


Arg Lys Ile Phe Ser Asn Cys Asn Phe Asn Leu Ser Thr Leu Leu Arg 
                405                 410                 415     


Leu Val His Thr Asp Ser Phe Ser Cys Asn Asn Phe Asp Glu Ser Lys 
            420                 425                 430         


Ile Tyr Gly Ser Cys Phe Lys Ser Ile Val Leu Asp Lys Phe Ala Ile 
        435                 440                 445             


Pro Asn Ser Arg Arg Ser Asp Leu Gln Leu Gly Ser Ser Gly Phe Leu 
    450                 455                 460                 


Gln Ser Ser Asn Tyr Lys Ile Asp Thr Thr Ser Ser Ser Cys Gln Leu 
465                 470                 475                 480 


Tyr Tyr Ser Leu Pro Ala Ile Asn Val Thr Ile Asn Asn Tyr Asn Pro 
                485                 490                 495     


Ser Ser Trp Asn Arg Arg Tyr Gly Phe Asn Asn Phe Asn Leu Ser Ser 
            500                 505                 510         


His Ser Val Val Tyr Ser Arg Tyr Cys Phe Ser Val Asn Asn Thr Phe 
        515                 520                 525             


Cys Pro Cys Ala Lys Pro Ser Phe Ala Ser Ser Cys Lys Ser His Lys 
    530                 535                 540                 


Pro Pro Ser Ala Ser Cys Pro Ile Gly Thr Asn Tyr Arg Ser Cys Glu 
545                 550                 555                 560 


Ser Thr Thr Val Leu Asp His Thr Asp Trp Cys Arg Cys Ser Cys Leu 
                565                 570                 575     


Pro Asp Pro Ile Thr Ala Tyr Asp Pro Arg Ser Cys Ser Gln Lys Lys 
            580                 585                 590         


Ser Leu Val Gly Val Gly Glu His Cys Ala Gly Phe Gly Val Asp Glu 
        595                 600                 605             


Glu Lys Cys Gly Val Leu Asp Gly Ser Tyr Asn Val Ser Cys Leu Cys 
    610                 615                 620                 


Ser Thr Asp Ala Phe Leu Gly Trp Ser Tyr Asp Thr Cys Val Ser Asn 
625                 630                 635                 640 


Asn Arg Cys Asn Ile Phe Ser Asn Phe Ile Leu Asn Gly Cys Gly Gly 
                645                 650                 655     


Gly Gly Ser Ser Ile Val Ser Leu Pro Val Tyr His Lys His Thr Phe 
            660                 665                 670         


Ile Val Leu Tyr Val Asp Phe Lys Pro Gln Ser Gly Gly Gly Lys Cys 
        675                 680                 685             


Phe Asn Cys Tyr Pro Ala Gly Val Asn Ile Thr Leu Ala Asn Phe Asn 
    690                 695                 700                 


Glu Thr Lys Gly Pro Leu Cys Val Asp Thr Ser His Phe Thr Thr Lys 
705                 710                 715                 720 


Tyr Val Ala Val Tyr Ala Asn Val Gly Arg Trp Ser Ala Ser Ile Asn 
                725                 730                 735     


Thr Gly Asn Cys Pro Phe Ser Phe Gly Lys Val Asn Asn Phe Val Lys 
            740                 745                 750         


Phe Gly Ser Val Cys Phe Ser Leu Lys Asp Ile Pro Gly Gly Cys Ala 
        755                 760                 765             


Met Pro Ile Val Ala Asn Trp Ala Tyr Ser Lys Tyr Tyr Thr Ile Gly 
    770                 775                 780                 


Ser Leu Tyr Val Ser Trp Ser Asp Gly Asp Gly Ile Thr Gly Val Pro 
785                 790                 795                 800 


Gln Pro Val Glu Gly Val Ser Ser Gly Ser Gly Gly Gly Gly Glu Ser 
                805                 810                 815     


Gln Val Arg Gln Gln Phe Ser Lys Asp Ile Glu Lys Leu Leu Asn Glu 
            820                 825                 830         


Gln Val Asn Lys Glu Met Gln Ser Ser Asn Leu Tyr Met Ser Met Ser 
        835                 840                 845             


Ser Trp Cys Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe 
    850                 855                 860                 


Asp His Ala Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe 
865                 870                 875                 880 


Leu Asn Glu Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro 
                885                 890                 895     


Glu His Lys Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu 
            900                 905                 910         


His Glu Gln His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala 
        915                 920                 925             


Ile Lys Ser Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val 
    930                 935                 940                 


Ala Glu Gln His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys 
945                 950                 955                 960 


Ile Glu Leu Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln 
                965                 970                 975     


Tyr Val Lys Gly Ile Ala Lys Ser Arg Lys Ser Gly Ser 
            980                 985                 


<210> 307
<211> 1061
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 307
Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg 
1               5                   10                  15      


Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val 
            20                  25                  30          


Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys 
        35                  40                  45              


Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn 
    50                  55                  60                  


Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile 
65                  70                  75                  80  


Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro 
                85                  90                  95      


Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp 
            100                 105                 110         


Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys 
        115                 120                 125             


Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln 
    130                 135                 140                 


Ala Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe 
145                 150                 155                 160 


Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln 
                165                 170                 175     


Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala 
            180                 185                 190         


Thr Val Cys Gly Gly Gly Gly Ser Thr Asn Leu Cys Pro Phe Gly Glu 
        195                 200                 205             


Val Phe Asn Ala Thr Lys Phe Pro Ser Val Tyr Ala Trp Glu Arg Lys 
    210                 215                 220                 


Lys Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser Thr 
225                 230                 235                 240 


Phe Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Ala Thr Lys Leu Asn 
                245                 250                 255     


Asp Leu Cys Phe Ser Asn Val Tyr Ala Asp Ser Phe Val Val Lys Gly 
            260                 265                 270         


Asp Asp Val Arg Gln Ile Ala Pro Gly Gln Thr Gly Val Ile Ala Asp 
        275                 280                 285             


Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Met Gly Cys Val Leu Ala Trp 
    290                 295                 300                 


Asn Thr Arg Asn Ile Asp Ala Thr Ser Thr Gly Asn Tyr Asn Tyr Lys 
305                 310                 315                 320 


Tyr Arg Tyr Leu Arg His Gly Lys Leu Arg Pro Phe Glu Arg Asp Ile 
                325                 330                 335     


Ser Asn Val Pro Phe Ser Pro Asp Gly Lys Pro Cys Thr Pro Pro Ala 
            340                 345                 350         


Leu Asn Cys Tyr Trp Pro Leu Asn Asp Tyr Gly Phe Tyr Thr Thr Thr 
        355                 360                 365             


Gly Ile Gly Tyr Gln Pro Cys Gly Gly Gly Gly Ser Asp Cys Asp Ile 
    370                 375                 380                 


Asp Lys Trp Leu Asn Asn Phe Asn Val Pro Ser Pro Leu Asn Trp Glu 
385                 390                 395                 400 


Arg Lys Ile Phe Ser Asn Cys Asn Phe Asn Leu Ser Thr Leu Leu Arg 
                405                 410                 415     


Leu Val His Thr Asp Ser Phe Ser Cys Asn Asn Phe Asp Glu Ser Lys 
            420                 425                 430         


Ile Tyr Gly Ser Cys Phe Lys Ser Ile Val Leu Asp Lys Phe Ala Ile 
        435                 440                 445             


Pro Asn Ser Arg Arg Ser Asp Leu Gln Leu Gly Ser Ser Gly Phe Leu 
    450                 455                 460                 


Gln Ser Ser Asn Tyr Lys Ile Asp Thr Thr Ser Ser Ser Cys Gln Leu 
465                 470                 475                 480 


Tyr Tyr Ser Leu Pro Ala Ile Asn Val Thr Ile Asn Asn Tyr Asn Pro 
                485                 490                 495     


Ser Ser Trp Asn Arg Arg Tyr Gly Phe Asn Asn Phe Asn Leu Ser Ser 
            500                 505                 510         


His Ser Val Val Tyr Ser Arg Tyr Cys Phe Ser Val Asn Asn Thr Phe 
        515                 520                 525             


Cys Pro Cys Ala Lys Pro Ser Phe Ala Ser Ser Cys Lys Ser His Lys 
    530                 535                 540                 


Pro Pro Ser Ala Ser Cys Pro Ile Gly Thr Asn Tyr Arg Ser Cys Glu 
545                 550                 555                 560 


Ser Thr Thr Val Leu Asp His Thr Asp Trp Cys Arg Cys Ser Cys Leu 
                565                 570                 575     


Pro Asp Pro Ile Thr Ala Tyr Asp Pro Arg Ser Cys Ser Gln Lys Lys 
            580                 585                 590         


Ser Leu Val Gly Val Gly Glu His Cys Ala Gly Phe Gly Val Asp Glu 
        595                 600                 605             


Glu Lys Cys Gly Val Leu Asp Gly Ser Tyr Asn Val Ser Cys Leu Cys 
    610                 615                 620                 


Ser Thr Asp Ala Phe Leu Gly Trp Ser Tyr Asp Thr Cys Val Ser Asn 
625                 630                 635                 640 


Asn Arg Cys Asn Ile Phe Ser Asn Phe Ile Leu Asn Gly Cys Gly Gly 
                645                 650                 655     


Gly Gly Ser Glu Ala Lys Pro Ser Gly Ser Val Val Glu Gln Ala Glu 
            660                 665                 670         


Gly Val Glu Cys Asp Phe Ser Pro Leu Leu Ser Gly Thr Pro Pro Gln 
        675                 680                 685             


Val Tyr Asn Phe Lys Arg Leu Val Phe Thr Asn Cys Asn Tyr Asn Leu 
    690                 695                 700                 


Thr Lys Leu Leu Ser Leu Phe Ser Val Asn Asp Phe Thr Cys Ser Gln 
705                 710                 715                 720 


Ile Ser Pro Ala Ala Ile Ala Ser Asn Cys Tyr Ser Ser Leu Ile Leu 
                725                 730                 735     


Asp Tyr Phe Ser Tyr Pro Leu Ser Met Lys Ser Asp Leu Ser Val Ser 
            740                 745                 750         


Ser Ala Gly Pro Ile Ser Gln Phe Asn Tyr Lys Gln Ser Phe Ser Asn 
        755                 760                 765             


Pro Thr Cys Leu Ile Leu Ala Thr Val Pro His Asn Leu Thr Thr Ile 
    770                 775                 780                 


Thr Lys Pro Leu Lys Tyr Ser Tyr Ile Asn Lys Cys Ser Arg Phe Leu 
785                 790                 795                 800 


Ser Asp Asp Arg Thr Glu Val Pro Gln Leu Val Asn Ala Asn Gln Tyr 
                805                 810                 815     


Ser Pro Cys Val Ser Ile Val Pro Ser Thr Val Trp Glu Asp Gly Asp 
            820                 825                 830         


Tyr Tyr Arg Lys Gln Leu Ser Pro Leu Glu Gly Gly Gly Trp Leu Val 
        835                 840                 845             


Ala Ser Gly Ser Thr Val Ala Met Thr Glu Gln Leu Gln Met Gly Phe 
    850                 855                 860                 


Gly Ile Thr Val Gln Tyr Gly Thr Asp Thr Asn Ser Val Cys Pro Lys 
865                 870                 875                 880 


Gly Ser Gly Gly Gly Gly Glu Ser Gln Val Arg Gln Gln Phe Ser Lys 
                885                 890                 895     


Asp Ile Glu Lys Leu Leu Asn Glu Gln Val Asn Lys Glu Met Gln Ser 
            900                 905                 910         


Ser Asn Leu Tyr Met Ser Met Ser Ser Trp Cys Tyr Thr His Ser Leu 
        915                 920                 925             


Asp Gly Ala Gly Leu Phe Leu Phe Asp His Ala Ala Glu Glu Tyr Glu 
    930                 935                 940                 


His Ala Lys Lys Leu Ile Ile Phe Leu Asn Glu Asn Asn Val Pro Val 
945                 950                 955                 960 


Gln Leu Thr Ser Ile Ser Ala Pro Glu His Lys Phe Glu Gly Leu Thr 
                965                 970                 975     


Gln Ile Phe Gln Lys Ala Tyr Glu His Glu Gln His Ile Ser Glu Ser 
            980                 985                 990         


Ile Asn Asn Ile Val Asp His Ala  Ile Lys Ser Lys Asp  His Ala Thr 
        995                 1000                 1005             


Phe Asn  Phe Leu Gln Trp Tyr  Val Ala Glu Gln His  Glu Glu Glu 
    1010                 1015                 1020             


Val Leu  Phe Lys Asp Ile Leu  Asp Lys Ile Glu Leu  Ile Gly Asn 
    1025                 1030                 1035             


Glu Asn  His Gly Leu Tyr Leu  Ala Asp Gln Tyr Val  Lys Gly Ile 
    1040                 1045                 1050             


Ala Lys  Ser Arg Lys Ser Gly  Ser 
    1055                 1060     


<210> 308
<211> 205
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 308
Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg 
1               5                   10                  15      


Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val 
            20                  25                  30          


Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys 
        35                  40                  45              


Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn 
    50                  55                  60                  


Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile 
65                  70                  75                  80  


Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro 
                85                  90                  95      


Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp 
            100                 105                 110         


Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys 
        115                 120                 125             


Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln 
    130                 135                 140                 


Ala Gly Ser Thr Pro Cys Asn Gly Val Lys Gly Phe Asn Cys Tyr Phe 
145                 150                 155                 160 


Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln 
                165                 170                 175     


Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala 
            180                 185                 190         


Thr Val Cys Gly Pro Gly Ser His His His His His His 
        195                 200                 205 


<210> 309
<211> 205
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 309
Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg 
1               5                   10                  15      


Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val 
            20                  25                  30          


Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys 
        35                  40                  45              


Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn 
    50                  55                  60                  


Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile 
65                  70                  75                  80  


Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro 
                85                  90                  95      


Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp 
            100                 105                 110         


Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys 
        115                 120                 125             


Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln 
    130                 135                 140                 


Ala Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe 
145                 150                 155                 160 


Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Tyr Gly Val Gly Tyr Gln 
                165                 170                 175     


Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala 
            180                 185                 190         


Thr Val Cys Gly Pro Gly Ser His His His His His His 
        195                 200                 205 


<210> 310
<211> 205
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 310
Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg 
1               5                   10                  15      


Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val 
            20                  25                  30          


Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys 
        35                  40                  45              


Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn 
    50                  55                  60                  


Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile 
65                  70                  75                  80  


Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro 
                85                  90                  95      


Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp 
            100                 105                 110         


Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys 
        115                 120                 125             


Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln 
    130                 135                 140                 


Ala Gly Ser Thr Pro Cys Asn Gly Val Lys Gly Phe Asn Cys Tyr Phe 
145                 150                 155                 160 


Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Tyr Gly Val Gly Tyr Gln 
                165                 170                 175     


Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala 
            180                 185                 190         


Thr Val Cys Gly Pro Gly Ser His His His His His His 
        195                 200                 205 


<210> 311
<211> 205
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 311
Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg 
1               5                   10                  15      


Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val 
            20                  25                  30          


Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys 
        35                  40                  45              


Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn 
    50                  55                  60                  


Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile 
65                  70                  75                  80  


Ala Pro Gly Gln Thr Gly Asn Ile Ala Asp Tyr Asn Tyr Lys Leu Pro 
                85                  90                  95      


Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp 
            100                 105                 110         


Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys 
        115                 120                 125             


Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln 
    130                 135                 140                 


Ala Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe 
145                 150                 155                 160 


Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln 
                165                 170                 175     


Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala 
            180                 185                 190         


Thr Val Cys Gly Pro Gly Ser His His His His His His 
        195                 200                 205 


<210> 312
<211> 205
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 312
Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg 
1               5                   10                  15      


Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val 
            20                  25                  30          


Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys 
        35                  40                  45              


Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn 
    50                  55                  60                  


Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile 
65                  70                  75                  80  


Ala Pro Gly Gln Thr Gly Asn Ile Ala Asp Tyr Asn Tyr Lys Leu Pro 
                85                  90                  95      


Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp 
            100                 105                 110         


Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys 
        115                 120                 125             


Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln 
    130                 135                 140                 


Ala Gly Ser Thr Pro Cys Asn Gly Val Lys Gly Phe Asn Cys Tyr Phe 
145                 150                 155                 160 


Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Tyr Gly Val Gly Tyr Gln 
                165                 170                 175     


Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala 
            180                 185                 190         


Thr Val Cys Gly Pro Gly Ser His His His His His His 
        195                 200                 205 


<210> 313
<211> 675
<212> PRT
<213> Severe acute respiratory syndrome coronavirus 2

<400> 313
Ser Ser Gln Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala 
1               5                   10                  15      


Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe 
            20                  25                  30          


Arg Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe 
        35                  40                  45              


Ser Asn Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly 
    50                  55                  60                  


Thr Lys Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr 
65                  70                  75                  80  


Phe Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly 
                85                  90                  95      


Thr Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala 
            100                 105                 110         


Thr Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro 
        115                 120                 125             


Phe Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser 
    130                 135                 140                 


Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val 
145                 150                 155                 160 


Ser Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys 
                165                 170                 175     


Asn Leu Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile 
            180                 185                 190         


Tyr Ser Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly 
        195                 200                 205             


Phe Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile 
    210                 215                 220                 


Thr Arg Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro 
225                 230                 235                 240 


Gly Asp Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val 
                245                 250                 255     


Gly Tyr Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly 
            260                 265                 270         


Thr Ile Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr 
        275                 280                 285             


Lys Cys Thr Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr 
    290                 295                 300                 


Ser Asn Phe Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn 
305                 310                 315                 320 


Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe 
                325                 330                 335     


Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala 
            340                 345                 350         


Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys 
        355                 360                 365             


Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val 
    370                 375                 380                 


Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala 
385                 390                 395                 400 


Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp 
                405                 410                 415     


Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser 
            420                 425                 430         


Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser 
        435                 440                 445             


Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala 
    450                 455                 460                 


Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro 
465                 470                 475                 480 


Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro 
                485                 490                 495     


Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr 
            500                 505                 510         


Val Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val 
        515                 520                 525             


Asn Phe Asn Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser 
    530                 535                 540                 


Asn Lys Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp 
545                 550                 555                 560 


Thr Thr Asp Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile 
                565                 570                 575     


Thr Pro Cys Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn 
            580                 585                 590         


Thr Ser Asn Gln Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu 
        595                 600                 605             


Val Pro Val Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val 
    610                 615                 620                 


Tyr Ser Thr Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile 
625                 630                 635                 640 


Gly Ala Glu His Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly 
                645                 650                 655     


Ala Gly Ile Cys Ala Ser Tyr Gln Thr Gly Gly Ser Gln Ser Ile Ile 
            660                 665                 670         


Ala Tyr Thr 
        675 


<210> 314
<211> 1127
<212> PRT
<213> Severe acute respiratory syndrome-related coronavirus

<400> 314
Ser Asp Leu Asp Arg Cys Thr Thr Phe Asp Asp Val Gln Ala Pro Asn 
1               5                   10                  15      


Tyr Thr Gln His Thr Ser Ser Met Arg Gly Val Tyr Tyr Pro Asp Glu 
            20                  25                  30          


Ile Phe Arg Ser Asp Thr Leu Tyr Leu Thr Gln Asp Leu Phe Leu Pro 
        35                  40                  45              


Phe Tyr Ser Asn Val Thr Gly Phe His Thr Ile Asn His Thr Phe Gly 
    50                  55                  60                  


Asn Pro Val Ile Pro Phe Lys Asp Gly Ile Tyr Phe Ala Ala Thr Glu 
65                  70                  75                  80  


Lys Ser Asn Val Val Arg Gly Trp Val Phe Gly Ser Thr Met Asn Asn 
                85                  90                  95      


Lys Ser Gln Ser Val Ile Ile Ile Asn Asn Ser Thr Asn Val Val Ile 
            100                 105                 110         


Arg Ala Cys Asn Phe Glu Leu Cys Asp Asn Pro Phe Phe Ala Val Ser 
        115                 120                 125             


Lys Pro Met Gly Thr Gln Thr His Thr Met Ile Phe Asp Asn Ala Phe 
    130                 135                 140                 


Asn Cys Thr Phe Glu Tyr Ile Ser Asp Ala Phe Ser Leu Asp Val Ser 
145                 150                 155                 160 


Glu Lys Ser Gly Asn Phe Lys His Leu Arg Glu Phe Val Phe Lys Asn 
                165                 170                 175     


Lys Asp Gly Phe Leu Tyr Val Tyr Lys Gly Tyr Gln Pro Ile Asp Val 
            180                 185                 190         


Val Arg Asp Leu Pro Ser Gly Phe Asn Thr Leu Lys Pro Ile Phe Lys 
        195                 200                 205             


Leu Pro Leu Gly Ile Asn Ile Thr Asn Phe Arg Ala Ile Leu Thr Ala 
    210                 215                 220                 


Phe Ser Pro Ala Gln Asp Ile Trp Gly Thr Ser Ala Ala Ala Tyr Phe 
225                 230                 235                 240 


Val Gly Tyr Leu Lys Pro Thr Thr Phe Met Leu Lys Tyr Asp Glu Asn 
                245                 250                 255     


Gly Thr Ile Thr Asp Ala Val Asp Cys Ser Gln Asn Pro Leu Ala Glu 
            260                 265                 270         


Leu Lys Cys Ser Val Lys Ser Phe Glu Ile Asp Lys Gly Ile Tyr Gln 
        275                 280                 285             


Thr Ser Asn Phe Arg Val Val Pro Ser Gly Asp Val Val Arg Phe Pro 
    290                 295                 300                 


Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Lys 
305                 310                 315                 320 


Phe Pro Ser Val Tyr Ala Trp Glu Arg Lys Lys Ile Ser Asn Cys Val 
                325                 330                 335     


Ala Asp Tyr Ser Val Leu Tyr Asn Ser Thr Phe Phe Ser Thr Phe Lys 
            340                 345                 350         


Cys Tyr Gly Val Ser Ala Thr Lys Leu Asn Asp Leu Cys Phe Ser Asn 
        355                 360                 365             


Val Tyr Ala Asp Ser Phe Val Val Lys Gly Asp Asp Val Arg Gln Ile 
    370                 375                 380                 


Ala Pro Gly Gln Thr Gly Val Ile Ala Asp Tyr Asn Tyr Lys Leu Pro 
385                 390                 395                 400 


Asp Asp Phe Met Gly Cys Val Leu Ala Trp Asn Thr Arg Asn Ile Asp 
                405                 410                 415     


Ala Thr Ser Thr Gly Asn Tyr Asn Tyr Lys Tyr Arg Tyr Leu Arg His 
            420                 425                 430         


Gly Lys Leu Arg Pro Phe Glu Arg Asp Ile Ser Asn Val Pro Phe Ser 
        435                 440                 445             


Pro Asp Gly Lys Pro Cys Thr Pro Pro Ala Leu Asn Cys Tyr Trp Pro 
    450                 455                 460                 


Leu Asn Asp Tyr Gly Phe Tyr Thr Thr Thr Gly Ile Gly Tyr Gln Pro 
465                 470                 475                 480 


Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu Asn Ala Pro Ala Thr 
                485                 490                 495     


Val Cys Gly Pro Lys Leu Ser Thr Asp Leu Ile Lys Asn Gln Cys Val 
            500                 505                 510         


Asn Phe Asn Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Pro Ser 
        515                 520                 525             


Ser Lys Arg Phe Gln Pro Phe Gln Gln Phe Gly Arg Asp Val Ser Asp 
    530                 535                 540                 


Phe Thr Asp Ser Val Arg Asp Pro Lys Thr Ser Glu Ile Leu Asp Ile 
545                 550                 555                 560 


Ser Pro Cys Ala Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn 
                565                 570                 575     


Ala Ser Ser Glu Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Asp 
            580                 585                 590         


Val Ser Thr Ala Ile His Ala Asp Gln Leu Thr Pro Ala Trp Arg Ile 
        595                 600                 605             


Tyr Ser Thr Gly Asn Asn Val Phe Gln Thr Gln Ala Gly Cys Leu Ile 
    610                 615                 620                 


Gly Ala Glu His Val Asp Thr Ser Tyr Glu Cys Asp Ile Pro Ile Gly 
625                 630                 635                 640 


Ala Gly Ile Cys Ala Ser Tyr His Thr Val Ser Leu Leu Arg Ser Thr 
                645                 650                 655     


Ser Gln Lys Ser Ile Val Ala Tyr Thr Met Ser Leu Gly Ala Asp Ser 
            660                 665                 670         


Ser Ile Ala Tyr Ser Asn Asn Thr Ile Ala Ile Pro Thr Asn Phe Ser 
        675                 680                 685             


Ile Ser Ile Thr Thr Glu Val Met Pro Val Ser Met Ala Lys Thr Ser 
    690                 695                 700                 


Val Asp Cys Asn Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ala Asn 
705                 710                 715                 720 


Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu 
                725                 730                 735     


Ser Gly Ile Ala Ala Glu Gln Asp Arg Asn Thr Arg Glu Val Phe Ala 
            740                 745                 750         


Gln Val Lys Gln Met Tyr Lys Thr Pro Thr Leu Lys Tyr Phe Gly Gly 
        755                 760                 765             


Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Leu Lys Pro Thr Lys Arg 
    770                 775                 780                 


Ser Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala 
785                 790                 795                 800 


Gly Phe Met Lys Gln Tyr Gly Glu Cys Leu Gly Asp Ile Asn Ala Arg 
                805                 810                 815     


Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro 
            820                 825                 830         


Leu Leu Thr Asp Asp Met Ile Ala Ala Tyr Thr Ala Ala Leu Val Ser 
        835                 840                 845             


Gly Thr Ala Thr Ala Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln 
    850                 855                 860                 


Ile Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val 
865                 870                 875                 880 


Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Gln Ile Ala Asn Gln Phe 
                885                 890                 895     


Asn Lys Ala Ile Ser Gln Ile Gln Glu Ser Leu Thr Thr Thr Ser Thr 
            900                 905                 910         


Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu 
        915                 920                 925             


Asn Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser 
    930                 935                 940                 


Val Leu Asn Asp Ile Leu Ser Arg Leu Asp Pro Pro Glu Ala Glu Val 
945                 950                 955                 960 


Gln Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser Leu Gln Thr Tyr 
                965                 970                 975     


Val Thr Gln Gln Leu Ile Arg Ala Ala Glu Ile Arg Ala Ser Ala Asn 
            980                 985                 990         


Leu Ala Ala Thr Lys Met Ser Glu  Cys Val Leu Gly Gln  Ser Lys Arg 
        995                 1000                 1005             


Val Asp  Phe Cys Gly Lys Gly  Tyr His Leu Met Ser  Phe Pro Gln 
    1010                 1015                 1020             


Ala Ala  Pro His Gly Val Val  Phe Leu His Val Thr  Tyr Val Pro 
    1025                 1030                 1035             


Ser Gln  Glu Arg Asn Phe Thr  Thr Ala Pro Ala Ile  Cys His Glu 
    1040                 1045                 1050             


Gly Lys  Ala Tyr Phe Pro Arg  Glu Gly Val Phe Val  Phe Asn Gly 
    1055                 1060                 1065             


Thr Ser  Trp Phe Ile Thr Gln  Arg Asn Phe Phe Ser  Pro Gln Ile 
    1070                 1075                 1080             


Ile Thr  Thr Asp Asn Thr Phe  Val Ser Gly Asn Cys  Asp Val Val 
    1085                 1090                 1095             


Ile Gly  Ile Ile Asn Asn Thr  Val Tyr Asp Pro Leu  Gln Ser Glu 
    1100                 1105                 1110             


Leu Asp  Ser Ile Lys Glu Glu  Leu Asp Lys Ile His  Lys Asn 
    1115                 1120                 1125         


<210> 315
<211> 4
<212> PRT
<213> Severe acute respiratory syndrome coronavirus 2

<400> 315
Arg Arg Ala Ser 
1               


<210> 316
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 316
Gly Ser Ala Ser 
1               


<210> 317
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      His tag


<220>
<221> SITE
<222> (1)..(10) 
<223> This sequence may encompass 5-10 residues

<400> 317
His His His His His His His His His His 
1               5                   10  


<210> 318
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      6xHis tag

<400> 318
His His His His His His 
1               5       


<210> 319
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 319
tcgtggtatt cttgctag                                                     18


<210> 320
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 320
gaaggtttta caagactcac                                                   20


<210> 321
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      probe

<400> 321
acactagcca tccttactgc g                                                 21


<210> 322
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 322
cgatctcttg tagatctgtt ctc                                               23


<210> 323
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 323
ctctgagagc ggctctattg g                                                 21


<210> 324
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 324
gttccctaca acgagcctaa attc                                              24


<210> 325
<211> 26
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      probe

<400> 325
tcagacacgc ggtccgctat aacgat                                            26


<210> 326
<211> 62
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 326
taatacgact cactataggg gaattgtgcg tggatgaggc gatctcttgt agatctgttc       60

tc                                                                      62


<210> 327
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 327
His His His His His His His His 
1               5               


<210> 328
<211> 22
<212> PRT
<213> Severe acute respiratory syndrome coronavirus 2

<400> 328
Pro Leu Gln Pro Glu Leu Asp Ser Phe Lys Glu Glu Leu Asp Lys Tyr 
1               5                   10                  15      


Phe Lys Asn Thr Ser Pro 
            20          


<210> 329
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 329
Pro Leu Gln Pro Glu Leu Asp Ser Phe Lys Glu Glu Leu Asp Lys 
1               5                   10                  15  


<210> 330
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 330
Pro Leu Gln Ser Glu Leu Asp Ser Ile Lys Glu Glu Leu Asp Lys Ile 
1               5                   10                  15      


His Lys Asn 
            


<210> 331
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 331
Gly Ser Gly Gly Ser Gly Glu Ser Gln Val Arg Gln Gln Phe Ser Lys 
1               5                   10                  15      


<210> 332
<211> 30
<212> PRT
<213> Severe acute respiratory syndrome coronavirus 2

<400> 332
Cys Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser 
1               5                   10                  15      


Val Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly 
            20                  25                  30  


<210> 333
<211> 30
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 333
Cys Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro Gly Ser Ala Ser Ser 
1               5                   10                  15      


Val Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly 
            20                  25                  30  


<210> 334
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 334
Cys Ala Ser Tyr Gln Thr 
1               5       


<210> 335
<211> 26
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 335
Cys Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro Gly Ser Ala Ser Ser 
1               5                   10                  15      


Val Ala Ser Gln Ser Ile Ile Ala Tyr Thr 
            20                  25      


<210> 336
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 336
Cys Ala Ser Tyr Gln Thr Gly Gly Ser Gln Ser Ile Ile Ala Tyr Thr 
1               5                   10                  15      


<210> 337
<211> 33
<212> PRT
<213> Severe acute respiratory syndrome coronavirus 2

<400> 337
Pro Leu Gln Pro Glu Leu Asp Ser Phe Lys Glu Glu Leu Asp Lys Tyr 
1               5                   10                  15      


Phe Lys Asn Thr Ser Pro Asp Val Asp Leu Gly Asp Ile Ser Gly Ile 
            20                  25                  30          


Asn 
    


<210> 338
<211> 33
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 338
Pro Leu Gln Ser Glu Leu Asp Ser Ile Lys Glu Glu Leu Asp Lys Ile 
1               5                   10                  15      


His Lys Asn Leu Asp Ser Ile Lys Glu Glu Leu Asp Lys Ile His Lys 
            20                  25                  30          


Asn 
    


<210> 339
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 339
Met Gly Ile Leu 
1               


<210> 340
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 340
Gly Ile Val Asn Asn Thr Val 
1               5           


<210> 341
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 341
Gly Lys Tyr Glu Gln 
1               5   


<210> 342
<211> 22
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 342
Val Asn Asn Thr Val Tyr Asp Pro Leu Gln Pro Glu Leu Asp Ser Phe 
1               5                   10                  15      


Lys Glu Glu Leu Asp Lys 
            20          


<210> 343
<211> 26
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 343
Val Asn Asn Thr Val Tyr Asp Pro Leu Gln Ser Glu Leu Asp Ser Ile 
1               5                   10                  15      


Lys Glu Glu Leu Asp Lys Ile His Lys Asn 
            20                  25      


<210> 344
<211> 26
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 344
Val Asn Asn Thr Val Tyr Asp Pro Leu Gln Ser Glu Ile Asp Ser Ile 
1               5                   10                  15      


Lys Glu Glu Ile Asp Lys Ile His Lys Asn 
            20                  25      


<210> 345
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 345
Ser Phe Leu Gly Arg Ser 
1               5       


<210> 346
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 346
Glu Ser Gln Val Arg Gln Gln Phe Ser Lys Gly Ser Gly Gly Ser Gly 
1               5                   10                  15      


