                         SEQUENCE LISTING

<110>  University of Pittsburgh - Of the Commonwealth System of 
       Higher Education
 
<120>  2019-NCOV SUBUNIT VACCINE AND MICRONEEDLE ARRAY DELIVERY SYSTEM

<130>  45049-0051WO1

<140>  PCT/US2021/021192
<141>  2021-03-05

<150>  62/985,498
<151>  2020-03-05

<150>  62/989,208
<151>  2020-03-13

<150>  17/009,121
<151>  2020-09-01

<160>  11    

<170>  PatentIn version 3.5

<210>  1
<211>  1992
<212>  DNA
<213>  Coronavirus (SARS-CoV-2)

<400>  1
gagaacggca cgatcaccga tgccgtggat tgtgcgctgg acccgctgtc ggagacaaag       60

tgcacgctga agtcgtttac cgtggagaag gggatctacc agacatctaa cttccgggtt      120

cagcccactg agtccatcgt atgttcgtgt tcctggtcct gctcccactg gtgtcctcgc      180

agtgcgtgaa cctgaccacc cgcacccagc tgccccctgc gtacaccaac tccatcacca      240

ggggcgtcta ctatcccgac aaggtgtttc gaagttccgt tctgcactcg acccaagacc      300

tgttcctccc cttcttcagc aacgtgacct ggttccatgc tatccacgta tcgggtacga      360

acgggaccaa gcgcttcgac aaccccgtcc tgcccttcaa cgacggcgtg tactttgcat      420

ccaccgagaa gtcgaacatt atcagggggt ggattttcgg caccacccta gactcgaaga      480

cacagtcgct gctgatcgtg aacaacgcga ccaatgtcgt catcaaggtt tgcgaattcc      540

agttctgcaa tgaccccttc ctgggagtct actaccacaa gaacaacaag agctggatgg      600

agagtgagtt cagagtgtat tcctccgcta acaattgcac cttcgagtac gtatcccagc      660

ccttcctgat ggacctggag ggcaagcagg ggaactttaa aaatctgcgc gagttcgtgt      720

ttaagaacat cgacggctac ttcaagatct atagtaagca cacacccata aatctggtcc      780

gcgacctgcc gcaaggcttc tccgctttgg aacccctcgt ggacctgccg attgggatca      840

acatcacacg ttttcagact ctcctggccc tgcaccggag ttacctgaca cccggtgact      900

cctcctcagg ctggactgcc ggggccgccg cttactacgt cggctatttg cagcccagaa      960

ctttcctcct gaagtataac gcgcttcccc aacatcacga atctctgccc cttcggcgag     1020

gtgttcaacg caactcgctt cgccagtgtg tacgcctgga accgcaagcg gatttccaat     1080

tgtgtcgctg actacagtgt gctttacaac tctgcctcat tcagtacgtt caagtgttac     1140

ggcgtgtccc cgaccaagct gaatgatctg tgcttcacca acgtatacgc cgactcgttt     1200

gtcatccgcg gcgatgaagt gaggcagatc gcgcccggcc agacgggcaa gatcgccgac     1260

tacaactaca agctgcccga tgatttcact ggctgtgtta ttgcttggaa tagtaacaat     1320

ctggactcga aggtcggggg gaactacaac tatctctata ggctcttcag aaaaagtaat     1380

ctgaagcctt tcgagcgcga catctcgact gagatatatc aggcaggctc caccccctgc     1440

aacggcgtgg aggggtttaa ttgctacttc ccccttcaga gctacggctt tcagccaaca     1500

aacggcgtag gctatcagcc ctaccgcgtg gtggtgctgt cattcgaact cctgcacgcc     1560

cccgcaaccg tctgcggccc taagaagagt acgaacctgg tgaagaacaa gtgcgtcaac     1620

ttcaatttca acggcctcac cggcacaggg gtgctgaccg agtccaacaa gaagtttctc     1680

ccgttccagc agtttgggag ggacatcgca gacactaccg acgcggtgag ggacccacag     1740

accttggaga tactggacat cactccttgc agcttcgggg gcgtgtcggt cataactccc     1800

ggcactaaca cctcaaacca ggtcgccgtg ctctaccagg acgtgaactg taccgaggtg     1860

cccgtggcga ttcacgccga ccagctgaca cccacgtgga gggtgtactc caccggaagt     1920

aatgtcttcc agacccgcgc cgggtgtctg ataggcgccg agcacgtcaa caactcgtac     1980

gagggatcct ga                                                         1992


<210>  2
<211>  663
<212>  PRT
<213>  Coronavirus (SARS-CoV-2)

<400>  2

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Ile 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
                245                 250                 255     


Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270         


Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285             


Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                 


Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
305                 310                 315                 320 


Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 
                325                 330                 335     


Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 
            340                 345                 350         


Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
        355                 360                 365             


Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
    370                 375                 380                 


Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
385                 390                 395                 400 


Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
                405                 410                 415     


Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
            420                 425                 430         


Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
        435                 440                 445             


Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
    450                 455                 460                 


Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
465                 470                 475                 480 


Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
                485                 490                 495     


Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
            500                 505                 510         


Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
        515                 520                 525             


Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
    530                 535                 540                 


Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
545                 550                 555                 560 


Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 
                565                 570                 575     


Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 
            580                 585                 590         


Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 
        595                 600                 605             


Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile 
    610                 615                 620                 


His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 
625                 630                 635                 640 


Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val 
                645                 650                 655     


Asn Asn Ser Tyr Glu Gly Ser 
            660             


<210>  3
<211>  2010
<212>  DNA
<213>  Coronavirus (SARS-CoV-2)

<400>  3
atgttcgtgt tcctggtcct gctcccactg gtgtcctcgc agtgcgtgaa cctgaccacc       60

cgcacccagc tgccccctgc gtacaccaac tccatcacca ggggcgtcta ctatcccgac      120

aaggtgtttc gaagttccgt tctgcactcg acccaagacc tgttcctccc cttcttcagc      180

aacgtgacct ggttccatgc tatccacgta tcgggtacga acgggaccaa gcgcttcgac      240

aaccccgtcc tgcccttcaa cgacggcgtg tactttgcat ccaccgagaa gtcgaacatt      300

atcagggggt ggattttcgg caccacccta gactcgaaga cacagtcgct gctgatcgtg      360

aacaacgcga ccaatgtcgt catcaaggtt tgcgaattcc agttctgcaa tgaccccttc      420

ctgggagtct actaccacaa gaacaacaag agctggatgg agagtgagtt cagagtgtat      480

tcctccgcta acaattgcac cttcgagtac gtatcccagc ccttcctgat ggacctggag      540

ggcaagcagg ggaactttaa aaatctgcgc gagttcgtgt ttaagaacat cgacggctac      600

ttcaagatct atagtaagca cacacccata aatctggtcc gcgacctgcc gcaaggcttc      660

tccgctttgg aacccctcgt ggacctgccg attgggatca acatcacacg ttttcagact      720

ctcctggccc tgcaccggag ttacctgaca cccggtgact cctcctcagg ctggactgcc      780

ggggccgccg cttactacgt cggctatttg cagcccagaa ctttcctcct gaagtataac      840

gagaacggca cgatcaccga tgccgtggat tgtgcgctgg acccgctgtc ggagacaaag      900

tgcacgctga agtcgtttac cgtggagaag gggatctacc agacatctaa cttccgggtt      960

cagcccactg agtccatcgt gcgcttcccc aacatcacga atctctgccc cttcggcgag     1020

gtgttcaacg caactcgctt cgccagtgtg tacgcctgga accgcaagcg gatttccaat     1080

tgtgtcgctg actacagtgt gctttacaac tctgcctcat tcagtacgtt caagtgttac     1140

ggcgtgtccc cgaccaagct gaatgatctg tgcttcacca acgtatacgc cgactcgttt     1200

gtcatccgcg gcgatgaagt gaggcagatc gcgcccggcc agacgggcaa gatcgccgac     1260

tacaactaca agctgcccga tgatttcact ggctgtgtta ttgcttggaa tagtaacaat     1320

ctggactcga aggtcggggg gaactacaac tatctctata ggctcttcag aaaaagtaat     1380

ctgaagcctt tcgagcgcga catctcgact gagatatatc aggcaggctc caccccctgc     1440

aacggcgtgg aggggtttaa ttgctacttc ccccttcaga gctacggctt tcagccaaca     1500

aacggcgtag gctatcagcc ctaccgcgtg gtggtgctgt cattcgaact cctgcacgcc     1560

cccgcaaccg tctgcggccc taagaagagt acgaacctgg tgaagaacaa gtgcgtcaac     1620

ttcaatttca acggcctcac cggcacaggg gtgctgaccg agtccaacaa gaagtttctc     1680

ccgttccagc agtttgggag ggacatcgca gacactaccg acgcggtgag ggacccacag     1740

accttggaga tactggacat cactccttgc agcttcgggg gcgtgtcggt cataactccc     1800

ggcactaaca cctcaaacca ggtcgccgtg ctctaccagg acgtgaactg taccgaggtg     1860

cccgtggcga ttcacgccga ccagctgaca cccacgtgga gggtgtactc caccggaagt     1920

aatgtcttcc agacccgcgc cgggtgtctg ataggcgccg agcacgtcaa caactcgtac     1980

gagggatccc accatcacca ccaccactga                                      2010


<210>  4
<211>  669
<212>  PRT
<213>  Coronavirus (SARS-CoV-2)

<400>  4

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Ile 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
                245                 250                 255     


Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270         


Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285             


Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                 


Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
305                 310                 315                 320 


Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 
                325                 330                 335     


Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 
            340                 345                 350         


Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
        355                 360                 365             


Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
    370                 375                 380                 


Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
385                 390                 395                 400 


Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
                405                 410                 415     


Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
            420                 425                 430         


Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
        435                 440                 445             


Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
    450                 455                 460                 


Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
465                 470                 475                 480 


Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
                485                 490                 495     


Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
            500                 505                 510         


Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
        515                 520                 525             


Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
    530                 535                 540                 


Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
545                 550                 555                 560 


Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 
                565                 570                 575     


Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 
            580                 585                 590         


Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 
        595                 600                 605             


Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile 
    610                 615                 620                 


His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 
625                 630                 635                 640 


Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val 
                645                 650                 655     


Asn Asn Ser Tyr Glu Gly Ser His His His His His His 
            660                 665                 


<210>  5
<211>  2094
<212>  DNA
<213>  Coronavirus (SARS-CoV-2)

<400>  5
atgttcgtgt tcctggtcct gctcccactg gtgtcctcgc agtgcgtgaa cctgaccacc       60

cgcacccagc tgccccctgc gtacaccaac tccatcacca ggggcgtcta ctatcccgac      120

aaggtgtttc gaagttccgt tctgcactcg acccaagacc tgttcctccc cttcttcagc      180

aacgtgacct ggttccatgc tatccacgta tcgggtacga acgggaccaa gcgcttcgac      240

aaccccgtcc tgcccttcaa cgacggcgtg tactttgcat ccaccgagaa gtcgaacatt      300

atcagggggt ggattttcgg caccacccta gactcgaaga cacagtcgct gctgatcgtg      360

aacaacgcga ccaatgtcgt catcaaggtt tgcgaattcc agttctgcaa tgaccccttc      420

ctgggagtct actaccacaa gaacaacaag agctggatgg agagtgagtt cagagtgtat      480

tcctccgcta acaattgcac cttcgagtac gtatcccagc ccttcctgat ggacctggag      540

ggcaagcagg ggaactttaa aaatctgcgc gagttcgtgt ttaagaacat cgacggctac      600

ttcaagatct atagtaagca cacacccata aatctggtcc gcgacctgcc gcaaggcttc      660

tccgctttgg aacccctcgt ggacctgccg attgggatca acatcacacg ttttcagact      720

ctcctggccc tgcaccggag ttacctgaca cccggtgact cctcctcagg ctggactgcc      780

ggggccgccg cttactacgt cggctatttg cagcccagaa ctttcctcct gaagtataac      840

gagaacggca cgatcaccga tgccgtggat tgtgcgctgg acccgctgtc ggagacaaag      900

tgcacgctga agtcgtttac cgtggagaag gggatctacc agacatctaa cttccgggtt      960

cagcccactg agtccatcgt gcgcttcccc aacatcacga atctctgccc cttcggcgag     1020

gtgttcaacg caactcgctt cgccagtgtg tacgcctgga accgcaagcg gatttccaat     1080

tgtgtcgctg actacagtgt gctttacaac tctgcctcat tcagtacgtt caagtgttac     1140

ggcgtgtccc cgaccaagct gaatgatctg tgcttcacca acgtatacgc cgactcgttt     1200

gtcatccgcg gcgatgaagt gaggcagatc gcgcccggcc agacgggcaa gatcgccgac     1260

tacaactaca agctgcccga tgatttcact ggctgtgtta ttgcttggaa tagtaacaat     1320

ctggactcga aggtcggggg gaactacaac tatctctata ggctcttcag aaaaagtaat     1380

ctgaagcctt tcgagcgcga catctcgact gagatatatc aggcaggctc caccccctgc     1440

aacggcgtgg aggggtttaa ttgctacttc ccccttcaga gctacggctt tcagccaaca     1500

aacggcgtag gctatcagcc ctaccgcgtg gtggtgctgt cattcgaact cctgcacgcc     1560

cccgcaaccg tctgcggccc taagaagagt acgaacctgg tgaagaacaa gtgcgtcaac     1620

ttcaatttca acggcctcac cggcacaggg gtgctgaccg agtccaacaa gaagtttctc     1680

ccgttccagc agtttgggag ggacatcgca gacactaccg acgcggtgag ggacccacag     1740

accttggaga tactggacat cactccttgc agcttcgggg gcgtgtcggt cataactccc     1800

ggcactaaca cctcaaacca ggtcgccgtg ctctaccagg acgtgaactg taccgaggtg     1860

cccgtggcga ttcacgccga ccagctgaca cccacgtgga gggtgtactc caccggaagt     1920

aatgtcttcc agacccgcgc cgggtgtctg ataggcgccg agcacgtcaa caactcgtac     1980

gagggatccg ggtacatccc cgaggcccct cgcgatggcc aagcttatgt gcgaaaggac     2040

ggggagtggg tgctgctctc caccttcctg gccccccccc acgcactgag ctga           2094


<210>  6
<211>  697
<212>  PRT
<213>  Coronavirus (SARS-CoV-2)

<400>  6

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Ile 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
                245                 250                 255     


Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270         


Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285             


Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                 


Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
305                 310                 315                 320 


Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 
                325                 330                 335     


Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 
            340                 345                 350         


Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
        355                 360                 365             


Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
    370                 375                 380                 


Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
385                 390                 395                 400 


Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
                405                 410                 415     


Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
            420                 425                 430         


Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
        435                 440                 445             


Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
    450                 455                 460                 


Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
465                 470                 475                 480 


Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
                485                 490                 495     


Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
            500                 505                 510         


Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
        515                 520                 525             


Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
    530                 535                 540                 


Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
545                 550                 555                 560 


Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 
                565                 570                 575     


Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 
            580                 585                 590         


Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 
        595                 600                 605             


Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile 
    610                 615                 620                 


His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 
625                 630                 635                 640 


Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val 
                645                 650                 655     


Asn Asn Ser Tyr Glu Gly Ser Gly Tyr Ile Pro Glu Ala Pro Arg Asp 
            660                 665                 670         


Gly Gln Ala Tyr Val Arg Lys Asp Gly Glu Trp Val Leu Leu Ser Thr 
        675                 680                 685             


Phe Leu Ala Pro Pro His Ala Leu Ser 
    690                 695         


<210>  7
<211>  2133
<212>  DNA
<213>  Coronavirus (SARS-CoV-2)

<400>  7
atgttcgtgt tcctggtcct gctcccactg gtgtcctcgc agtgcgtgaa cctgaccacc       60

cgcacccagc tgccccctgc gtacaccaac tccatcacca ggggcgtcta ctatcccgac      120

aaggtgtttc gaagttccgt tctgcactcg acccaagacc tgttcctccc cttcttcagc      180

aacgtgacct ggttccatgc tatccacgta tcgggtacga acgggaccaa gcgcttcgac      240

aaccccgtcc tgcccttcaa cgacggcgtg tactttgcat ccaccgagaa gtcgaacatt      300

atcagggggt ggattttcgg caccacccta gactcgaaga cacagtcgct gctgatcgtg      360

aacaacgcga ccaatgtcgt catcaaggtt tgcgaattcc agttctgcaa tgaccccttc      420

ctgggagtct actaccacaa gaacaacaag agctggatgg agagtgagtt cagagtgtat      480

tcctccgcta acaattgcac cttcgagtac gtatcccagc ccttcctgat ggacctggag      540

ggcaagcagg ggaactttaa aaatctgcgc gagttcgtgt ttaagaacat cgacggctac      600

ttcaagatct atagtaagca cacacccata aatctggtcc gcgacctgcc gcaaggcttc      660

tccgctttgg aacccctcgt ggacctgccg attgggatca acatcacacg ttttcagact      720

ctcctggccc tgcaccggag ttacctgaca cccggtgact cctcctcagg ctggactgcc      780

ggggccgccg cttactacgt cggctatttg cagcccagaa ctttcctcct gaagtataac      840

gagaacggca cgatcaccga tgccgtggat tgtgcgctgg acccgctgtc ggagacaaag      900

tgcacgctga agtcgtttac cgtggagaag gggatctacc agacatctaa cttccgggtt      960

cagcccactg agtccatcgt gcgcttcccc aacatcacga atctctgccc cttcggcgag     1020

gtgttcaacg caactcgctt cgccagtgtg tacgcctgga accgcaagcg gatttccaat     1080

tgtgtcgctg actacagtgt gctttacaac tctgcctcat tcagtacgtt caagtgttac     1140

ggcgtgtccc cgaccaagct gaatgatctg tgcttcacca acgtatacgc cgactcgttt     1200

gtcatccgcg gcgatgaagt gaggcagatc gcgcccggcc agacgggcaa gatcgccgac     1260

tacaactaca agctgcccga tgatttcact ggctgtgtta ttgcttggaa tagtaacaat     1320

ctggactcga aggtcggggg gaactacaac tatctctata ggctcttcag aaaaagtaat     1380

ctgaagcctt tcgagcgcga catctcgact gagatatatc aggcaggctc caccccctgc     1440

aacggcgtgg aggggtttaa ttgctacttc ccccttcaga gctacggctt tcagccaaca     1500

aacggcgtag gctatcagcc ctaccgcgtg gtggtgctgt cattcgaact cctgcacgcc     1560

cccgcaaccg tctgcggccc taagaagagt acgaacctgg tgaagaacaa gtgcgtcaac     1620

ttcaatttca acggcctcac cggcacaggg gtgctgaccg agtccaacaa gaagtttctc     1680

ccgttccagc agtttgggag ggacatcgca gacactaccg acgcggtgag ggacccacag     1740

accttggaga tactggacat cactccttgc agcttcgggg gcgtgtcggt cataactccc     1800

ggcactaaca cctcaaacca ggtcgccgtg ctctaccagg acgtgaactg taccgaggtg     1860

cccgtggcga ttcacgccga ccagctgaca cccacgtgga gggtgtactc caccggaagt     1920

aatgtcttcc agacccgcgc cgggtgtctg ataggcgccg agcacgtcaa caactcgtac     1980

gagggatccg ggtacatccc cgaggcccct cgcgatggcc aagcttatgt gcgaaaggac     2040

ggggagtggg tgctgctctc caccttcctg gccccccccc acgcactgag cgagaactta     2100

tacttcgagg gccaccatca ccaccaccat tga                                  2133


<210>  8
<211>  710
<212>  PRT
<213>  Coronavirus (SARS-CoV-2)

<400>  8

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Ile 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
                245                 250                 255     


Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270         


Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285             


Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                 


Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
305                 310                 315                 320 


Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 
                325                 330                 335     


Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 
            340                 345                 350         


Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
        355                 360                 365             


Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
    370                 375                 380                 


Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
385                 390                 395                 400 


Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
                405                 410                 415     


Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
            420                 425                 430         


Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
        435                 440                 445             


Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
    450                 455                 460                 


Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
465                 470                 475                 480 


Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
                485                 490                 495     


Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
            500                 505                 510         


Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
        515                 520                 525             


Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
    530                 535                 540                 


Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
545                 550                 555                 560 


Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 
                565                 570                 575     


Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 
            580                 585                 590         


Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 
        595                 600                 605             


Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile 
    610                 615                 620                 


His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 
625                 630                 635                 640 


Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val 
                645                 650                 655     


Asn Asn Ser Tyr Glu Gly Ser Gly Tyr Ile Pro Glu Ala Pro Arg Asp 
            660                 665                 670         


Gly Gln Ala Tyr Val Arg Lys Asp Gly Glu Trp Val Leu Leu Ser Thr 
        675                 680                 685             


Phe Leu Ala Pro Pro His Ala Leu Ser Glu Asn Leu Tyr Phe Glu Gly 
    690                 695                 700                 


His His His His His His 
705                 710 


<210>  9
<211>  229
<212>  PRT
<213>  Homo sapiens

<400>  9

Asp Lys Thr His Thr Cys Pro Ser Arg Pro Cys Pro Ala Pro Glu Leu 
1               5                   10                  15      


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            20                  25                  30          


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        35                  40                  45              


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
    50                  55                  60                  


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
65                  70                  75                  80  


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                85                  90                  95      


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
            100                 105                 110         


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        115                 120                 125             


Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
    130                 135                 140                 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
145                 150                 155                 160 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                165                 170                 175     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
            180                 185                 190         


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
        195                 200                 205             


Val Leu His Glu Ala Leu His Ser His Tyr Thr Gln Lys Ser Leu Ser 
    210                 215                 220                 


Leu Ser Pro Gly Lys 
225                 


<210>  10
<211>  27
<212>  PRT
<213>  Escherichia virus T4

<400>  10

Gly Tyr Ile Pro Glu Ala Pro Arg Asp Gly Gln Ala Tyr Val Arg Lys 
1               5                   10                  15      


Asp Gly Glu Trp Val Leu Leu Ser Thr Phe Leu 
            20                  25          


<210>  11
<211>  64
<212>  PRT
<213>  Homo sapiens

<400>  11

Val Thr Ala Phe Ser Asn Met Asp Asp Met Leu Gln Lys Ala His Leu 
1               5                   10                  15      


Val Ile Glu Gly Thr Phe Ile Tyr Leu Arg Asp Ser Thr Glu Phe Phe 
            20                  25                  30          


Ile Arg Val Arg Asp Gly Trp Lys Lys Leu Gln Leu Gly Glu Leu Ile 
        35                  40                  45              


Pro Ile Pro Ala Asp Ser Pro Pro Pro Pro Ala Leu Ser Ser Asn Pro 
    50                  55                  60                  


