                         SEQUENCE LISTING

<110>  NellOne Therapeutics, Inc.
 
<120>  METHODS AND COMPOSITIONS FOR TREATING MUSCLE ATROPHY

<130>  N88509 1070WO

<150>  62/986,327
<151>  2020-03-06

<160>  20    

<170>  PatentIn version 3.5

<210>  1
<211>  3255
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  NELL1 isoform 1

<220>
<221>  CDS
<222>  (154)..(2586)

<400>  1
atatgcgagc gcagcacccg gcgctgccga gccacctccc ccgccgcccg ctagcaagtt       60

tggcggctcc aagccaggcg cgcctcagga tccaggctca tttgcttcca cctagcttcg      120

gtgccccctg ctaggcgggg accctcgaga gcg atg ccg atg gat ttg att tta       174
                                     Met Pro Met Asp Leu Ile Leu          
                                     1               5                    

gtt gtg tgg ttc tgt gtg tgc act gcc agg aca gtg gtg ggc ttt ggg        222
Val Val Trp Phe Cys Val Cys Thr Ala Arg Thr Val Val Gly Phe Gly           
        10                  15                  20                        

atg gac cct gac ctt cag atg gat atc gtc acc gag ctt gac ctt gtg        270
Met Asp Pro Asp Leu Gln Met Asp Ile Val Thr Glu Leu Asp Leu Val           
    25                  30                  35                            

aac acc acc ctt gga gtt gct cag gtg tct gga atg cac aat gcc agc        318
Asn Thr Thr Leu Gly Val Ala Gln Val Ser Gly Met His Asn Ala Ser           
40                  45                  50                  55            

aaa gca ttt tta ttt caa gac ata gaa aga gag atc cat gca gct cct        366
Lys Ala Phe Leu Phe Gln Asp Ile Glu Arg Glu Ile His Ala Ala Pro           
                60                  65                  70                

cat gtg agt gag aaa tta att cag ctg ttc cgg aac aag agt gaa ttc        414
His Val Ser Glu Lys Leu Ile Gln Leu Phe Arg Asn Lys Ser Glu Phe           
            75                  80                  85                    

acc att ttg gcc act gta cag cag aag cca tcc act tca gga gtg ata        462
Thr Ile Leu Ala Thr Val Gln Gln Lys Pro Ser Thr Ser Gly Val Ile           
        90                  95                  100                       

ctg tcc att cga gaa ctg gag cac agc tat ttt gaa ctg gag agc agt        510
Leu Ser Ile Arg Glu Leu Glu His Ser Tyr Phe Glu Leu Glu Ser Ser           
    105                 110                 115                           

ggc ctg agg gat gag att cgg tat cac tac ata cac aat ggg aag cca        558
Gly Leu Arg Asp Glu Ile Arg Tyr His Tyr Ile His Asn Gly Lys Pro           
120                 125                 130                 135           

agg aca gag gca ctt cct tac cgc atg gca gat gga caa tgg cac aag        606
Arg Thr Glu Ala Leu Pro Tyr Arg Met Ala Asp Gly Gln Trp His Lys           
                140                 145                 150               

gtt gca ctg tca gtt agc gcc tct cat ctc ctg ctc cat gtc gac tgt        654
Val Ala Leu Ser Val Ser Ala Ser His Leu Leu Leu His Val Asp Cys           
            155                 160                 165                   

aac agg att tat gag cgt gtg ata gac cct cca gat acc aac ctt ccc        702
Asn Arg Ile Tyr Glu Arg Val Ile Asp Pro Pro Asp Thr Asn Leu Pro           
        170                 175                 180                       

cca gga atc aat tta tgg ctt ggc cag cgc aac caa aag cat ggc tta        750
Pro Gly Ile Asn Leu Trp Leu Gly Gln Arg Asn Gln Lys His Gly Leu           
    185                 190                 195                           

ttc aaa ggg atc atc caa gat ggg aag atc atc ttt atg ccg aat gga        798
Phe Lys Gly Ile Ile Gln Asp Gly Lys Ile Ile Phe Met Pro Asn Gly           
200                 205                 210                 215           

tat ata aca cag tgt cca aat cta aat cac act tgc cca acc tgc agt        846
Tyr Ile Thr Gln Cys Pro Asn Leu Asn His Thr Cys Pro Thr Cys Ser           
                220                 225                 230               

gat ttc tta agc ctg gtg caa gga ata atg gat tta caa gag ctt ttg        894
Asp Phe Leu Ser Leu Val Gln Gly Ile Met Asp Leu Gln Glu Leu Leu           
            235                 240                 245                   

gcc aag atg act gca aaa cta aat tat gca gag aca aga ctt agt caa        942
Ala Lys Met Thr Ala Lys Leu Asn Tyr Ala Glu Thr Arg Leu Ser Gln           
        250                 255                 260                       

ttg gaa aac tgt cat tgt gag aag act tgt caa gtg agt gga ctg ctc        990
Leu Glu Asn Cys His Cys Glu Lys Thr Cys Gln Val Ser Gly Leu Leu           
    265                 270                 275                           

tat cga gat caa gac tct tgg gta gat ggt gac cat tgc agg aac tgc       1038
Tyr Arg Asp Gln Asp Ser Trp Val Asp Gly Asp His Cys Arg Asn Cys           
280                 285                 290                 295           

act tgc aaa agt ggt gcc gtg gaa tgc cga agg atg tcc tgt ccc cct       1086
Thr Cys Lys Ser Gly Ala Val Glu Cys Arg Arg Met Ser Cys Pro Pro           
                300                 305                 310               

ctc aat tgc tcc cca gac tcc ctc cca gtg cac att gct ggc cag tgc       1134
Leu Asn Cys Ser Pro Asp Ser Leu Pro Val His Ile Ala Gly Gln Cys           
            315                 320                 325                   

tgt aag gtc tgc cga cca aaa tgt atc tat gga gga aaa gtt ctt gca       1182
Cys Lys Val Cys Arg Pro Lys Cys Ile Tyr Gly Gly Lys Val Leu Ala           
        330                 335                 340                       

gaa ggc cag cgg att tta acc aag agc tgt cgg gaa tgc cga ggt gga       1230
Glu Gly Gln Arg Ile Leu Thr Lys Ser Cys Arg Glu Cys Arg Gly Gly           
    345                 350                 355                           

gtt tta gta aaa att aca gaa atg tgt cct cct ttg aac tgc tca gaa       1278
Val Leu Val Lys Ile Thr Glu Met Cys Pro Pro Leu Asn Cys Ser Glu           
360                 365                 370                 375           

aag gat cac att ctt cct gag aat cag tgc tgc cgt gtc tgt aga ggt       1326
Lys Asp His Ile Leu Pro Glu Asn Gln Cys Cys Arg Val Cys Arg Gly           
                380                 385                 390               

cat aac ttt tgt gca gaa gga cct aaa tgt ggt gaa aac tca gag tgc       1374
His Asn Phe Cys Ala Glu Gly Pro Lys Cys Gly Glu Asn Ser Glu Cys           
            395                 400                 405                   

aaa aac tgg aat aca aaa gct act tgt gag tgc aag agt ggt tac atc       1422
Lys Asn Trp Asn Thr Lys Ala Thr Cys Glu Cys Lys Ser Gly Tyr Ile           
        410                 415                 420                       

tct gtc cag gga gac tct gcc tac tgt gaa gat att gat gag tgt gca       1470
Ser Val Gln Gly Asp Ser Ala Tyr Cys Glu Asp Ile Asp Glu Cys Ala           
    425                 430                 435                           

gct aag atg cat tac tgt cat gcc aat act gtg tgt gtc aac ctt cct       1518
Ala Lys Met His Tyr Cys His Ala Asn Thr Val Cys Val Asn Leu Pro           
440                 445                 450                 455           

ggg tta tat cgc tgt gac tgt gtc cca gga tac att cgt gtg gat gac       1566
Gly Leu Tyr Arg Cys Asp Cys Val Pro Gly Tyr Ile Arg Val Asp Asp           
                460                 465                 470               

ttc tct tgt aca gaa cac gat gaa tgt ggc agc ggc cag cac aac tgt       1614
Phe Ser Cys Thr Glu His Asp Glu Cys Gly Ser Gly Gln His Asn Cys           
            475                 480                 485                   

gat gag aat gcc atc tgc acc aac act gtc cag gga cac agc tgc acc       1662
Asp Glu Asn Ala Ile Cys Thr Asn Thr Val Gln Gly His Ser Cys Thr           
        490                 495                 500                       

tgc aaa ccg ggc tac gtg ggg aac ggg acc atc tgc aga gct ttc tgt       1710
Cys Lys Pro Gly Tyr Val Gly Asn Gly Thr Ile Cys Arg Ala Phe Cys           
    505                 510                 515                           

gaa gag ggc tgc aga tac ggt gga acg tgt gtg gct ccc aac aaa tgt       1758
Glu Glu Gly Cys Arg Tyr Gly Gly Thr Cys Val Ala Pro Asn Lys Cys           
520                 525                 530                 535           

gtc tgt cca tct gga ttc aca gga agc cac tgc gag aaa gat att gat       1806
Val Cys Pro Ser Gly Phe Thr Gly Ser His Cys Glu Lys Asp Ile Asp           
                540                 545                 550               

gaa tgt tca gag gga atc att gag tgc cac aac cat tcc cgc tgc gtt       1854
Glu Cys Ser Glu Gly Ile Ile Glu Cys His Asn His Ser Arg Cys Val           
            555                 560                 565                   

aac ctg cca ggg tgg tac cac tgt gag tgc aga agc ggt ttc cat gac       1902
Asn Leu Pro Gly Trp Tyr His Cys Glu Cys Arg Ser Gly Phe His Asp           
        570                 575                 580                       

gat ggg acc tat tca ctg tcc ggg gag tcc tgt att gac att gat gaa       1950
Asp Gly Thr Tyr Ser Leu Ser Gly Glu Ser Cys Ile Asp Ile Asp Glu           
    585                 590                 595                           

tgt gcc tta aga act cac acc tgt tgg aac gat tct gcc tgc atc aac       1998
Cys Ala Leu Arg Thr His Thr Cys Trp Asn Asp Ser Ala Cys Ile Asn           
600                 605                 610                 615           

ctg gca ggg ggc ttt gac tgt ctc tgc ccc tct ggg ccc tcc tgc tct       2046
Leu Ala Gly Gly Phe Asp Cys Leu Cys Pro Ser Gly Pro Ser Cys Ser           
                620                 625                 630               

ggt gac tgt cct cat gaa ggg ggg ctg aag cac aat ggc cag gtg tgg       2094
Gly Asp Cys Pro His Glu Gly Gly Leu Lys His Asn Gly Gln Val Trp           
            635                 640                 645                   

acc ttg aaa gaa gac agg tgt tct gtc tgc tcc tgc aag gat ggc aag       2142
Thr Leu Lys Glu Asp Arg Cys Ser Val Cys Ser Cys Lys Asp Gly Lys           
        650                 655                 660                       

ata ttc tgc cga cgg aca gct tgt gat tgc cag aat cca agt gct gac       2190
Ile Phe Cys Arg Arg Thr Ala Cys Asp Cys Gln Asn Pro Ser Ala Asp           
    665                 670                 675                           

cta ttc tgt tgc cca gaa tgt gac acc aga gtc aca agt caa tgt tta       2238
Leu Phe Cys Cys Pro Glu Cys Asp Thr Arg Val Thr Ser Gln Cys Leu           
680                 685                 690                 695           

gac caa aat ggt cac aag ctg tat cga agt gga gac aat tgg acc cat       2286
Asp Gln Asn Gly His Lys Leu Tyr Arg Ser Gly Asp Asn Trp Thr His           
                700                 705                 710               

agc tgt cag cag tgt cgg tgt ctg gaa gga gag gta gat tgc tgg cca       2334
Ser Cys Gln Gln Cys Arg Cys Leu Glu Gly Glu Val Asp Cys Trp Pro           
            715                 720                 725                   

ctc act tgc ccc aac ttg agc tgt gag tat aca gct atc tta gaa ggg       2382
Leu Thr Cys Pro Asn Leu Ser Cys Glu Tyr Thr Ala Ile Leu Glu Gly           
        730                 735                 740                       

gaa tgt tgt ccc cgc tgt gtc agt gac ccc tgc cta gct gat aac atc       2430
Glu Cys Cys Pro Arg Cys Val Ser Asp Pro Cys Leu Ala Asp Asn Ile           
    745                 750                 755                           

acc tat gac atc aga aaa act tgc ctg gac agc tat ggt gtt tca cgg       2478
Thr Tyr Asp Ile Arg Lys Thr Cys Leu Asp Ser Tyr Gly Val Ser Arg           
760                 765                 770                 775           

ctt agt ggc tca gtg tgg acg atg gct gga tct ccc tgc aca acc tgt       2526
Leu Ser Gly Ser Val Trp Thr Met Ala Gly Ser Pro Cys Thr Thr Cys           
                780                 785                 790               

aaa tgc aag aat gga aga gtc tgt tgt tct gtg gat ttt gag tgt ctt       2574
Lys Cys Lys Asn Gly Arg Val Cys Cys Ser Val Asp Phe Glu Cys Leu           
            795                 800                 805                   

caa aat aat tga agtatttaca gtggactcaa cgcagaagaa tggacgaaat           2626
Gln Asn Asn                                                               
        810                                                               

gaccatccaa cgtgattaag gataggaatc ggtagtttgg tttttttgtt tgttttgttt     2686

ttttaaccac agataattgc caaagtttcc acctgaggac ggtgtttgga ggttgccttt     2746

tggacctacc actttgctca ttcttgctaa cctagtctag gtgacctaca gtgccgtgca     2806

tttaagtcaa tggttgttaa aagaagtttc ccgtgttgta aatcatgttt cccttatcag     2866

atcatttgca aatacattta aatgatctca tggtaaatgt tgatgtattt tttggtttat     2926

tttgtgtact aacataatag agagagactc agctcctttt atttattttg ttgatttatg     2986

gatcaaattc taaaataaag ttgcctgttg tgacttttgt cccatctact gcatacttag     3046

tgctgagatc cctgtaaaat gttttgatga aaatatgtat gtagagtcca gtcgcattat     3106

acatacattt catagtgctg aaccttctta aatgcctact cattcagctt aaacaggctg     3166

aagccaagta tgacaaagag gggaagggcc aaaaacataa tcaaagaata attttaaaga     3226

gaattcttgt ctctcttgca aaaaaaaaa                                       3255


<210>  2
<211>  810
<212>  PRT
<213>  Homo sapiens

<220>
<221>  misc_feature
<223>  NELL1 isoform 1

<400>  2

Met Pro Met Asp Leu Ile Leu Val Val Trp Phe Cys Val Cys Thr Ala 
1               5                   10                  15      


Arg Thr Val Val Gly Phe Gly Met Asp Pro Asp Leu Gln Met Asp Ile 
            20                  25                  30          


Val Thr Glu Leu Asp Leu Val Asn Thr Thr Leu Gly Val Ala Gln Val 
        35                  40                  45              


Ser Gly Met His Asn Ala Ser Lys Ala Phe Leu Phe Gln Asp Ile Glu 
    50                  55                  60                  


Arg Glu Ile His Ala Ala Pro His Val Ser Glu Lys Leu Ile Gln Leu 
65                  70                  75                  80  


Phe Arg Asn Lys Ser Glu Phe Thr Ile Leu Ala Thr Val Gln Gln Lys 
                85                  90                  95      


Pro Ser Thr Ser Gly Val Ile Leu Ser Ile Arg Glu Leu Glu His Ser 
            100                 105                 110         


Tyr Phe Glu Leu Glu Ser Ser Gly Leu Arg Asp Glu Ile Arg Tyr His 
        115                 120                 125             


Tyr Ile His Asn Gly Lys Pro Arg Thr Glu Ala Leu Pro Tyr Arg Met 
    130                 135                 140                 


Ala Asp Gly Gln Trp His Lys Val Ala Leu Ser Val Ser Ala Ser His 
145                 150                 155                 160 


Leu Leu Leu His Val Asp Cys Asn Arg Ile Tyr Glu Arg Val Ile Asp 
                165                 170                 175     


Pro Pro Asp Thr Asn Leu Pro Pro Gly Ile Asn Leu Trp Leu Gly Gln 
            180                 185                 190         


Arg Asn Gln Lys His Gly Leu Phe Lys Gly Ile Ile Gln Asp Gly Lys 
        195                 200                 205             


Ile Ile Phe Met Pro Asn Gly Tyr Ile Thr Gln Cys Pro Asn Leu Asn 
    210                 215                 220                 


His Thr Cys Pro Thr Cys Ser Asp Phe Leu Ser Leu Val Gln Gly Ile 
225                 230                 235                 240 


Met Asp Leu Gln Glu Leu Leu Ala Lys Met Thr Ala Lys Leu Asn Tyr 
                245                 250                 255     


Ala Glu Thr Arg Leu Ser Gln Leu Glu Asn Cys His Cys Glu Lys Thr 
            260                 265                 270         


Cys Gln Val Ser Gly Leu Leu Tyr Arg Asp Gln Asp Ser Trp Val Asp 
        275                 280                 285             


Gly Asp His Cys Arg Asn Cys Thr Cys Lys Ser Gly Ala Val Glu Cys 
    290                 295                 300                 


Arg Arg Met Ser Cys Pro Pro Leu Asn Cys Ser Pro Asp Ser Leu Pro 
305                 310                 315                 320 


Val His Ile Ala Gly Gln Cys Cys Lys Val Cys Arg Pro Lys Cys Ile 
                325                 330                 335     


Tyr Gly Gly Lys Val Leu Ala Glu Gly Gln Arg Ile Leu Thr Lys Ser 
            340                 345                 350         


Cys Arg Glu Cys Arg Gly Gly Val Leu Val Lys Ile Thr Glu Met Cys 
        355                 360                 365             


Pro Pro Leu Asn Cys Ser Glu Lys Asp His Ile Leu Pro Glu Asn Gln 
    370                 375                 380                 


Cys Cys Arg Val Cys Arg Gly His Asn Phe Cys Ala Glu Gly Pro Lys 
385                 390                 395                 400 


Cys Gly Glu Asn Ser Glu Cys Lys Asn Trp Asn Thr Lys Ala Thr Cys 
                405                 410                 415     


Glu Cys Lys Ser Gly Tyr Ile Ser Val Gln Gly Asp Ser Ala Tyr Cys 
            420                 425                 430         


Glu Asp Ile Asp Glu Cys Ala Ala Lys Met His Tyr Cys His Ala Asn 
        435                 440                 445             


Thr Val Cys Val Asn Leu Pro Gly Leu Tyr Arg Cys Asp Cys Val Pro 
    450                 455                 460                 


Gly Tyr Ile Arg Val Asp Asp Phe Ser Cys Thr Glu His Asp Glu Cys 
465                 470                 475                 480 


Gly Ser Gly Gln His Asn Cys Asp Glu Asn Ala Ile Cys Thr Asn Thr 
                485                 490                 495     


Val Gln Gly His Ser Cys Thr Cys Lys Pro Gly Tyr Val Gly Asn Gly 
            500                 505                 510         


Thr Ile Cys Arg Ala Phe Cys Glu Glu Gly Cys Arg Tyr Gly Gly Thr 
        515                 520                 525             


Cys Val Ala Pro Asn Lys Cys Val Cys Pro Ser Gly Phe Thr Gly Ser 
    530                 535                 540                 


His Cys Glu Lys Asp Ile Asp Glu Cys Ser Glu Gly Ile Ile Glu Cys 
545                 550                 555                 560 


His Asn His Ser Arg Cys Val Asn Leu Pro Gly Trp Tyr His Cys Glu 
                565                 570                 575     


Cys Arg Ser Gly Phe His Asp Asp Gly Thr Tyr Ser Leu Ser Gly Glu 
            580                 585                 590         


Ser Cys Ile Asp Ile Asp Glu Cys Ala Leu Arg Thr His Thr Cys Trp 
        595                 600                 605             


Asn Asp Ser Ala Cys Ile Asn Leu Ala Gly Gly Phe Asp Cys Leu Cys 
    610                 615                 620                 


Pro Ser Gly Pro Ser Cys Ser Gly Asp Cys Pro His Glu Gly Gly Leu 
625                 630                 635                 640 


Lys His Asn Gly Gln Val Trp Thr Leu Lys Glu Asp Arg Cys Ser Val 
                645                 650                 655     


Cys Ser Cys Lys Asp Gly Lys Ile Phe Cys Arg Arg Thr Ala Cys Asp 
            660                 665                 670         


Cys Gln Asn Pro Ser Ala Asp Leu Phe Cys Cys Pro Glu Cys Asp Thr 
        675                 680                 685             


Arg Val Thr Ser Gln Cys Leu Asp Gln Asn Gly His Lys Leu Tyr Arg 
    690                 695                 700                 


Ser Gly Asp Asn Trp Thr His Ser Cys Gln Gln Cys Arg Cys Leu Glu 
705                 710                 715                 720 


Gly Glu Val Asp Cys Trp Pro Leu Thr Cys Pro Asn Leu Ser Cys Glu 
                725                 730                 735     


Tyr Thr Ala Ile Leu Glu Gly Glu Cys Cys Pro Arg Cys Val Ser Asp 
            740                 745                 750         


Pro Cys Leu Ala Asp Asn Ile Thr Tyr Asp Ile Arg Lys Thr Cys Leu 
        755                 760                 765             


Asp Ser Tyr Gly Val Ser Arg Leu Ser Gly Ser Val Trp Thr Met Ala 
    770                 775                 780                 


Gly Ser Pro Cys Thr Thr Cys Lys Cys Lys Asn Gly Arg Val Cys Cys 
785                 790                 795                 800 


Ser Val Asp Phe Glu Cys Leu Gln Asn Asn 
                805                 810 


<210>  3
<211>  3114
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  NELL1 isoform 2

<220>
<221>  CDS
<222>  (154)..(2445)

<400>  3
atatgcgagc gcagcacccg gcgctgccga gccacctccc ccgccgcccg ctagcaagtt       60

tggcggctcc aagccaggcg cgcctcagga tccaggctca tttgcttcca cctagcttcg      120

gtgccccctg ctaggcgggg accctcgaga gcg atg ccg atg gat ttg att tta       174
                                     Met Pro Met Asp Leu Ile Leu          
                                     1               5                    

gtt gtg tgg ttc tgt gtg tgc act gcc agg aca gtg gtg ggc ttt ggg        222
Val Val Trp Phe Cys Val Cys Thr Ala Arg Thr Val Val Gly Phe Gly           
        10                  15                  20                        

atg gac cct gac ctt cag atg gat atc gtc acc gag ctt gac ctt gtg        270
Met Asp Pro Asp Leu Gln Met Asp Ile Val Thr Glu Leu Asp Leu Val           
    25                  30                  35                            

aac acc acc ctt gga gtt gct cag gtg tct gga atg cac aat gcc agc        318
Asn Thr Thr Leu Gly Val Ala Gln Val Ser Gly Met His Asn Ala Ser           
40                  45                  50                  55            

aaa gca ttt tta ttt caa gac ata gaa aga gag atc cat gca gct cct        366
Lys Ala Phe Leu Phe Gln Asp Ile Glu Arg Glu Ile His Ala Ala Pro           
                60                  65                  70                

cat gtg agt gag aaa tta att cag ctg ttc cgg aac aag agt gaa ttc        414
His Val Ser Glu Lys Leu Ile Gln Leu Phe Arg Asn Lys Ser Glu Phe           
            75                  80                  85                    

acc att ttg gcc act gta cag cag aag cca tcc act tca gga gtg ata        462
Thr Ile Leu Ala Thr Val Gln Gln Lys Pro Ser Thr Ser Gly Val Ile           
        90                  95                  100                       

ctg tcc att cga gaa ctg gag cac agc tat ttt gaa ctg gag agc agt        510
Leu Ser Ile Arg Glu Leu Glu His Ser Tyr Phe Glu Leu Glu Ser Ser           
    105                 110                 115                           

ggc ctg agg gat gag att cgg tat cac tac ata cac aat ggg aag cca        558
Gly Leu Arg Asp Glu Ile Arg Tyr His Tyr Ile His Asn Gly Lys Pro           
120                 125                 130                 135           

agg aca gag gca ctt cct tac cgc atg gca gat gga caa tgg cac aag        606
Arg Thr Glu Ala Leu Pro Tyr Arg Met Ala Asp Gly Gln Trp His Lys           
                140                 145                 150               

gtt gca ctg tca gtt agc gcc tct cat ctc ctg ctc cat gtc gac tgt        654
Val Ala Leu Ser Val Ser Ala Ser His Leu Leu Leu His Val Asp Cys           
            155                 160                 165                   

aac agg att tat gag cgt gtg ata gac cct cca gat acc aac ctt ccc        702
Asn Arg Ile Tyr Glu Arg Val Ile Asp Pro Pro Asp Thr Asn Leu Pro           
        170                 175                 180                       

cca gga atc aat tta tgg ctt ggc cag cgc aac caa aag cat ggc tta        750
Pro Gly Ile Asn Leu Trp Leu Gly Gln Arg Asn Gln Lys His Gly Leu           
    185                 190                 195                           

ttc aaa ggg atc atc caa gat ggg aag atc atc ttt atg ccg aat gga        798
Phe Lys Gly Ile Ile Gln Asp Gly Lys Ile Ile Phe Met Pro Asn Gly           
200                 205                 210                 215           

tat ata aca cag tgt cca aat cta aat cac act tgc cca acc tgc agt        846
Tyr Ile Thr Gln Cys Pro Asn Leu Asn His Thr Cys Pro Thr Cys Ser           
                220                 225                 230               

gat ttc tta agc ctg gtg caa gga ata atg gat tta caa gag ctt ttg        894
Asp Phe Leu Ser Leu Val Gln Gly Ile Met Asp Leu Gln Glu Leu Leu           
            235                 240                 245                   

gcc aag atg act gca aaa cta aat tat gca gag aca aga ctt agt caa        942
Ala Lys Met Thr Ala Lys Leu Asn Tyr Ala Glu Thr Arg Leu Ser Gln           
        250                 255                 260                       

ttg gaa aac tgt cat tgt gag aag act tgt caa gtg agt gga ctg ctc        990
Leu Glu Asn Cys His Cys Glu Lys Thr Cys Gln Val Ser Gly Leu Leu           
    265                 270                 275                           

tat cga gat caa gac tct tgg gta gat ggt gac cat tgc agg aac tgc       1038
Tyr Arg Asp Gln Asp Ser Trp Val Asp Gly Asp His Cys Arg Asn Cys           
280                 285                 290                 295           

act tgc aaa agt ggt gcc gtg gaa tgc cga agg atg tcc tgt ccc cct       1086
Thr Cys Lys Ser Gly Ala Val Glu Cys Arg Arg Met Ser Cys Pro Pro           
                300                 305                 310               

ctc aat tgc tcc cca gac tcc ctc cca gtg cac att gct ggc cag tgc       1134
Leu Asn Cys Ser Pro Asp Ser Leu Pro Val His Ile Ala Gly Gln Cys           
            315                 320                 325                   

tgt aag gtc tgc cga cca aaa tgt atc tat gga gga aaa gtt ctt gca       1182
Cys Lys Val Cys Arg Pro Lys Cys Ile Tyr Gly Gly Lys Val Leu Ala           
        330                 335                 340                       

gaa ggc cag cgg att tta acc aag agc tgt cgg gaa tgc cga ggt gga       1230
Glu Gly Gln Arg Ile Leu Thr Lys Ser Cys Arg Glu Cys Arg Gly Gly           
    345                 350                 355                           

gtt tta gta aaa att aca gaa atg tgt cct cct ttg aac tgc tca gaa       1278
Val Leu Val Lys Ile Thr Glu Met Cys Pro Pro Leu Asn Cys Ser Glu           
360                 365                 370                 375           

aag gat cac att ctt cct gag aat cag tgc tgc cgt gtc tgt aga ggt       1326
Lys Asp His Ile Leu Pro Glu Asn Gln Cys Cys Arg Val Cys Arg Gly           
                380                 385                 390               

cat aac ttt tgt gca gaa gga cct aaa tgt ggt gaa aac tca gag tgc       1374
His Asn Phe Cys Ala Glu Gly Pro Lys Cys Gly Glu Asn Ser Glu Cys           
            395                 400                 405                   

aaa aac tgg aat aca aaa gct act tgt gag tgc aag agt ggt tac atc       1422
Lys Asn Trp Asn Thr Lys Ala Thr Cys Glu Cys Lys Ser Gly Tyr Ile           
        410                 415                 420                       

tct gtc cag gga gac tct gcc tac tgt gaa gat att gat gag tgt gca       1470
Ser Val Gln Gly Asp Ser Ala Tyr Cys Glu Asp Ile Asp Glu Cys Ala           
    425                 430                 435                           

gct aag atg cat tac tgt cat gcc aat act gtg tgt gtc aac ctt cct       1518
Ala Lys Met His Tyr Cys His Ala Asn Thr Val Cys Val Asn Leu Pro           
440                 445                 450                 455           

ggg tta tat cgc tgt gac tgt gtc cca gga tac att cgt gtg gat gac       1566
Gly Leu Tyr Arg Cys Asp Cys Val Pro Gly Tyr Ile Arg Val Asp Asp           
                460                 465                 470               

ttc tct tgt aca gaa cac gat gaa tgt ggc agc ggc cag cac aac tgt       1614
Phe Ser Cys Thr Glu His Asp Glu Cys Gly Ser Gly Gln His Asn Cys           
            475                 480                 485                   

gat gag aat gcc atc tgc acc aac act gtc cag gga cac agc tgc acc       1662
Asp Glu Asn Ala Ile Cys Thr Asn Thr Val Gln Gly His Ser Cys Thr           
        490                 495                 500                       

tgc aaa ccg ggc tac gtg ggg aac ggg acc atc tgc aga gct ttc tgt       1710
Cys Lys Pro Gly Tyr Val Gly Asn Gly Thr Ile Cys Arg Ala Phe Cys           
    505                 510                 515                           

gaa gag ggc tgc aga tac ggt gga acg tgt gtg gct ccc aac aaa tgt       1758
Glu Glu Gly Cys Arg Tyr Gly Gly Thr Cys Val Ala Pro Asn Lys Cys           
520                 525                 530                 535           

gtc tgt cca tct gga ttc aca gga agc cac tgc gag aaa gac att gat       1806
Val Cys Pro Ser Gly Phe Thr Gly Ser His Cys Glu Lys Asp Ile Asp           
                540                 545                 550               

gaa tgt gcc tta aga act cac acc tgt tgg aac gat tct gcc tgc atc       1854
Glu Cys Ala Leu Arg Thr His Thr Cys Trp Asn Asp Ser Ala Cys Ile           
            555                 560                 565                   

aac ctg gca ggg ggc ttt gac tgt ctc tgc ccc tct ggg ccc tcc tgc       1902
Asn Leu Ala Gly Gly Phe Asp Cys Leu Cys Pro Ser Gly Pro Ser Cys           
        570                 575                 580                       

tct ggt gac tgt cct cat gaa ggg ggg ctg aag cac aat ggc cag gtg       1950
Ser Gly Asp Cys Pro His Glu Gly Gly Leu Lys His Asn Gly Gln Val           
    585                 590                 595                           

tgg acc ttg aaa gaa gac agg tgt tct gtc tgc tcc tgc aag gat ggc       1998
Trp Thr Leu Lys Glu Asp Arg Cys Ser Val Cys Ser Cys Lys Asp Gly           
600                 605                 610                 615           

aag ata ttc tgc cga cgg aca gct tgt gat tgc cag aat cca agt gct       2046
Lys Ile Phe Cys Arg Arg Thr Ala Cys Asp Cys Gln Asn Pro Ser Ala           
                620                 625                 630               

gac cta ttc tgt tgc cca gaa tgt gac acc aga gtc aca agt caa tgt       2094
Asp Leu Phe Cys Cys Pro Glu Cys Asp Thr Arg Val Thr Ser Gln Cys           
            635                 640                 645                   

tta gac caa aat ggt cac aag ctg tat cga agt gga gac aat tgg acc       2142
Leu Asp Gln Asn Gly His Lys Leu Tyr Arg Ser Gly Asp Asn Trp Thr           
        650                 655                 660                       

cat agc tgt cag cag tgt cgg tgt ctg gaa gga gag gta gat tgc tgg       2190
His Ser Cys Gln Gln Cys Arg Cys Leu Glu Gly Glu Val Asp Cys Trp           
    665                 670                 675                           

cca ctc act tgc ccc aac ttg agc tgt gag tat aca gct atc tta gaa       2238
Pro Leu Thr Cys Pro Asn Leu Ser Cys Glu Tyr Thr Ala Ile Leu Glu           
680                 685                 690                 695           

ggg gaa tgt tgt ccc cgc tgt gtc agt gac ccc tgc cta gct gat aac       2286
Gly Glu Cys Cys Pro Arg Cys Val Ser Asp Pro Cys Leu Ala Asp Asn           
                700                 705                 710               

atc acc tat gac atc aga aaa act tgc ctg gac agc tat ggt gtt tca       2334
Ile Thr Tyr Asp Ile Arg Lys Thr Cys Leu Asp Ser Tyr Gly Val Ser           
            715                 720                 725                   

cgg ctt agt ggc tca gtg tgg acg atg gct gga tct ccc tgc aca acc       2382
Arg Leu Ser Gly Ser Val Trp Thr Met Ala Gly Ser Pro Cys Thr Thr           
        730                 735                 740                       

tgt aaa tgc aag aat gga aga gtc tgt tgt tct gtg gat ttt gag tgt       2430
Cys Lys Cys Lys Asn Gly Arg Val Cys Cys Ser Val Asp Phe Glu Cys           
    745                 750                 755                           

ctt caa aat aat tga agtatttaca gtggactcaa cgcagaagaa tggacgaaat       2485
Leu Gln Asn Asn                                                           
760                                                                       

gaccatccaa cgtgattaag gataggaatc ggtagtttgg tttttttgtt tgttttgttt     2545

ttttaaccac agataattgc caaagtttcc acctgaggac ggtgtttgga ggttgccttt     2605

tggacctacc actttgctca ttcttgctaa cctagtctag gtgacctaca gtgccgtgca     2665

tttaagtcaa tggttgttaa aagaagtttc ccgtgttgta aatcatgttt cccttatcag     2725

atcatttgca aatacattta aatgatctca tggtaaatgt tgatgtattt tttggtttat     2785

tttgtgtact aacataatag agagagactc agctcctttt atttattttg ttgatttatg     2845

gatcaaattc taaaataaag ttgcctgttg tgacttttgt cccatctact gcatacttag     2905

tgctgagatc cctgtaaaat gttttgatga aaatatgtat gtagagtcca gtcgcattat     2965

acatacattt catagtgctg aaccttctta aatgcctact cattcagctt aaacaggctg     3025

aagccaagta tgacaaagag gggaagggcc aaaaacataa tcaaagaata attttaaaga     3085

gaattcttgt ctctcttgca aaaaaaaaa                                       3114


<210>  4
<211>  763
<212>  PRT
<213>  Homo sapiens

<220>
<221>  misc_feature
<223>  NELL1 isoform 2

<400>  4

Met Pro Met Asp Leu Ile Leu Val Val Trp Phe Cys Val Cys Thr Ala 
1               5                   10                  15      


Arg Thr Val Val Gly Phe Gly Met Asp Pro Asp Leu Gln Met Asp Ile 
            20                  25                  30          


Val Thr Glu Leu Asp Leu Val Asn Thr Thr Leu Gly Val Ala Gln Val 
        35                  40                  45              


Ser Gly Met His Asn Ala Ser Lys Ala Phe Leu Phe Gln Asp Ile Glu 
    50                  55                  60                  


Arg Glu Ile His Ala Ala Pro His Val Ser Glu Lys Leu Ile Gln Leu 
65                  70                  75                  80  


Phe Arg Asn Lys Ser Glu Phe Thr Ile Leu Ala Thr Val Gln Gln Lys 
                85                  90                  95      


Pro Ser Thr Ser Gly Val Ile Leu Ser Ile Arg Glu Leu Glu His Ser 
            100                 105                 110         


Tyr Phe Glu Leu Glu Ser Ser Gly Leu Arg Asp Glu Ile Arg Tyr His 
        115                 120                 125             


Tyr Ile His Asn Gly Lys Pro Arg Thr Glu Ala Leu Pro Tyr Arg Met 
    130                 135                 140                 


Ala Asp Gly Gln Trp His Lys Val Ala Leu Ser Val Ser Ala Ser His 
145                 150                 155                 160 


Leu Leu Leu His Val Asp Cys Asn Arg Ile Tyr Glu Arg Val Ile Asp 
                165                 170                 175     


Pro Pro Asp Thr Asn Leu Pro Pro Gly Ile Asn Leu Trp Leu Gly Gln 
            180                 185                 190         


Arg Asn Gln Lys His Gly Leu Phe Lys Gly Ile Ile Gln Asp Gly Lys 
        195                 200                 205             


Ile Ile Phe Met Pro Asn Gly Tyr Ile Thr Gln Cys Pro Asn Leu Asn 
    210                 215                 220                 


His Thr Cys Pro Thr Cys Ser Asp Phe Leu Ser Leu Val Gln Gly Ile 
225                 230                 235                 240 


Met Asp Leu Gln Glu Leu Leu Ala Lys Met Thr Ala Lys Leu Asn Tyr 
                245                 250                 255     


Ala Glu Thr Arg Leu Ser Gln Leu Glu Asn Cys His Cys Glu Lys Thr 
            260                 265                 270         


Cys Gln Val Ser Gly Leu Leu Tyr Arg Asp Gln Asp Ser Trp Val Asp 
        275                 280                 285             


Gly Asp His Cys Arg Asn Cys Thr Cys Lys Ser Gly Ala Val Glu Cys 
    290                 295                 300                 


Arg Arg Met Ser Cys Pro Pro Leu Asn Cys Ser Pro Asp Ser Leu Pro 
305                 310                 315                 320 


Val His Ile Ala Gly Gln Cys Cys Lys Val Cys Arg Pro Lys Cys Ile 
                325                 330                 335     


Tyr Gly Gly Lys Val Leu Ala Glu Gly Gln Arg Ile Leu Thr Lys Ser 
            340                 345                 350         


Cys Arg Glu Cys Arg Gly Gly Val Leu Val Lys Ile Thr Glu Met Cys 
        355                 360                 365             


Pro Pro Leu Asn Cys Ser Glu Lys Asp His Ile Leu Pro Glu Asn Gln 
    370                 375                 380                 


Cys Cys Arg Val Cys Arg Gly His Asn Phe Cys Ala Glu Gly Pro Lys 
385                 390                 395                 400 


Cys Gly Glu Asn Ser Glu Cys Lys Asn Trp Asn Thr Lys Ala Thr Cys 
                405                 410                 415     


Glu Cys Lys Ser Gly Tyr Ile Ser Val Gln Gly Asp Ser Ala Tyr Cys 
            420                 425                 430         


Glu Asp Ile Asp Glu Cys Ala Ala Lys Met His Tyr Cys His Ala Asn 
        435                 440                 445             


Thr Val Cys Val Asn Leu Pro Gly Leu Tyr Arg Cys Asp Cys Val Pro 
    450                 455                 460                 


Gly Tyr Ile Arg Val Asp Asp Phe Ser Cys Thr Glu His Asp Glu Cys 
465                 470                 475                 480 


Gly Ser Gly Gln His Asn Cys Asp Glu Asn Ala Ile Cys Thr Asn Thr 
                485                 490                 495     


Val Gln Gly His Ser Cys Thr Cys Lys Pro Gly Tyr Val Gly Asn Gly 
            500                 505                 510         


Thr Ile Cys Arg Ala Phe Cys Glu Glu Gly Cys Arg Tyr Gly Gly Thr 
        515                 520                 525             


Cys Val Ala Pro Asn Lys Cys Val Cys Pro Ser Gly Phe Thr Gly Ser 
    530                 535                 540                 


His Cys Glu Lys Asp Ile Asp Glu Cys Ala Leu Arg Thr His Thr Cys 
545                 550                 555                 560 


Trp Asn Asp Ser Ala Cys Ile Asn Leu Ala Gly Gly Phe Asp Cys Leu 
                565                 570                 575     


Cys Pro Ser Gly Pro Ser Cys Ser Gly Asp Cys Pro His Glu Gly Gly 
            580                 585                 590         


Leu Lys His Asn Gly Gln Val Trp Thr Leu Lys Glu Asp Arg Cys Ser 
        595                 600                 605             


Val Cys Ser Cys Lys Asp Gly Lys Ile Phe Cys Arg Arg Thr Ala Cys 
    610                 615                 620                 


Asp Cys Gln Asn Pro Ser Ala Asp Leu Phe Cys Cys Pro Glu Cys Asp 
625                 630                 635                 640 


Thr Arg Val Thr Ser Gln Cys Leu Asp Gln Asn Gly His Lys Leu Tyr 
                645                 650                 655     


Arg Ser Gly Asp Asn Trp Thr His Ser Cys Gln Gln Cys Arg Cys Leu 
            660                 665                 670         


Glu Gly Glu Val Asp Cys Trp Pro Leu Thr Cys Pro Asn Leu Ser Cys 
        675                 680                 685             


Glu Tyr Thr Ala Ile Leu Glu Gly Glu Cys Cys Pro Arg Cys Val Ser 
    690                 695                 700                 


Asp Pro Cys Leu Ala Asp Asn Ile Thr Tyr Asp Ile Arg Lys Thr Cys 
705                 710                 715                 720 


Leu Asp Ser Tyr Gly Val Ser Arg Leu Ser Gly Ser Val Trp Thr Met 
                725                 730                 735     


Ala Gly Ser Pro Cys Thr Thr Cys Lys Cys Lys Asn Gly Arg Val Cys 
            740                 745                 750         


Cys Ser Val Asp Phe Glu Cys Leu Gln Asn Asn 
        755                 760             


<210>  5
<211>  2791
<212>  DNA
<213>  Equus caballus


<220>
<221>  misc_feature
<223>  NELL1 isoform 1

<220>
<221>  CDS
<222>  (1)..(2376)

<400>  5
atg ggc ttt ggg atg gac ccc gac ctt caa atg gat att atc acc gag         48
Met Gly Phe Gly Met Asp Pro Asp Leu Gln Met Asp Ile Ile Thr Glu           
1               5                   10                  15                

ctc gac ctc gtg aac acc acc ctt gga gtc act cag gtg tcc gga ctg         96
Leu Asp Leu Val Asn Thr Thr Leu Gly Val Thr Gln Val Ser Gly Leu           
            20                  25                  30                    

cac aat gcc agc aaa gca ttt tta ttt caa gat gta gag aga gag atc        144
His Asn Ala Ser Lys Ala Phe Leu Phe Gln Asp Val Glu Arg Glu Ile           
        35                  40                  45                        

cat gca gcc cca cac gtg agt gag aaa tta att cag ctg ttc cgg aat        192
His Ala Ala Pro His Val Ser Glu Lys Leu Ile Gln Leu Phe Arg Asn           
    50                  55                  60                            

aag agt gaa ttc acc ttt ttg gcc act gtg cag cag aag ccg tca act        240
Lys Ser Glu Phe Thr Phe Leu Ala Thr Val Gln Gln Lys Pro Ser Thr           
65                  70                  75                  80            

tca gga gtg ata ctg tcc att cga gaa ctg gaa aac agt tat ttt gaa        288
Ser Gly Val Ile Leu Ser Ile Arg Glu Leu Glu Asn Ser Tyr Phe Glu           
                85                  90                  95                

ctg gag agc agt ggc ctg aga gat gag att cga tat cac tac aca cac        336
Leu Glu Ser Ser Gly Leu Arg Asp Glu Ile Arg Tyr His Tyr Thr His           
            100                 105                 110                   

aag ggg aag ccc agg aca gag gca ctt ccc tac cgg atg gcg gac gga        384
Lys Gly Lys Pro Arg Thr Glu Ala Leu Pro Tyr Arg Met Ala Asp Gly           
        115                 120                 125                       

cgg tgg cac aag gtg gcg ctg tca gtt agc gcc tct cat ctc ctg ctc        432
Arg Trp His Lys Val Ala Leu Ser Val Ser Ala Ser His Leu Leu Leu           
    130                 135                 140                           

cac atc gac tgc aac agg att tat gaa cgt gtg ata gac act cct gag        480
His Ile Asp Cys Asn Arg Ile Tyr Glu Arg Val Ile Asp Thr Pro Glu           
145                 150                 155                 160           

acc aac ctc ccc cca gga agc aat ttg tgg ctg ggt cag cga aac caa        528
Thr Asn Leu Pro Pro Gly Ser Asn Leu Trp Leu Gly Gln Arg Asn Gln           
                165                 170                 175               

aag cac ggc tta ttc aaa gga atc atc caa gat gga aaa atc atc ttc        576
Lys His Gly Leu Phe Lys Gly Ile Ile Gln Asp Gly Lys Ile Ile Phe           
            180                 185                 190                   

atg ccg aat gga tac ata aca cag tgt ccg aac ctg aat cgc act tgc        624
Met Pro Asn Gly Tyr Ile Thr Gln Cys Pro Asn Leu Asn Arg Thr Cys           
        195                 200                 205                       

cca acg tgc agt gat ttc tta agc ctg gtg caa gga atc atg gat tta        672
Pro Thr Cys Ser Asp Phe Leu Ser Leu Val Gln Gly Ile Met Asp Leu           
    210                 215                 220                           

caa gag ctt ctg gcc aag atg act gcg aaa cta aat tat gca gag aca        720
Gln Glu Leu Leu Ala Lys Met Thr Ala Lys Leu Asn Tyr Ala Glu Thr           
225                 230                 235                 240           

cga ctt agt caa ttg gaa aac tgc cac tgc gag aag acc tgt caa gtg        768
Arg Leu Ser Gln Leu Glu Asn Cys His Cys Glu Lys Thr Cys Gln Val           
                245                 250                 255               

agt gga ctg ctc tat aga gac cag gac tcc tgg gtt gat ggc gat cac        816
Ser Gly Leu Leu Tyr Arg Asp Gln Asp Ser Trp Val Asp Gly Asp His           
            260                 265                 270                   

tgt agg aac tgc acg tgc aaa agc ggc gct gtg gaa tgt cgg agg atg        864
Cys Arg Asn Cys Thr Cys Lys Ser Gly Ala Val Glu Cys Arg Arg Met           
        275                 280                 285                       

tct tgt ccc cct ctc aat tgc tcc cca gac tcc ctc cct gtg cac gtt        912
Ser Cys Pro Pro Leu Asn Cys Ser Pro Asp Ser Leu Pro Val His Val           
    290                 295                 300                           

gcc ggc cag tgc tgt aag gtc tgc cga cca aaa tgt atc tac gga ggg        960
Ala Gly Gln Cys Cys Lys Val Cys Arg Pro Lys Cys Ile Tyr Gly Gly           
305                 310                 315                 320           

aaa gtc ctt gca gaa ggc cag cgg att tta acc aag agc tgt cgg gaa       1008
Lys Val Leu Ala Glu Gly Gln Arg Ile Leu Thr Lys Ser Cys Arg Glu           
                325                 330                 335               

tgc cga ggt gga gtt tta gtg aaa att aca gaa gcg tgc cct cct ttg       1056
Cys Arg Gly Gly Val Leu Val Lys Ile Thr Glu Ala Cys Pro Pro Leu           
            340                 345                 350                   

aac tgc tca gac aag gat cac att ctc cca gag aat cag tgc tgc agc       1104
Asn Cys Ser Asp Lys Asp His Ile Leu Pro Glu Asn Gln Cys Cys Ser           
        355                 360                 365                       

gtc tgc aga ggt cat aac ttt tgt gcg gaa gga cct aaa tgt ggt gaa       1152
Val Cys Arg Gly His Asn Phe Cys Ala Glu Gly Pro Lys Cys Gly Glu           
    370                 375                 380                           

aat tca gag tgc aaa aac tgg aat aca aaa gct act tgc gag tgc aag       1200
Asn Ser Glu Cys Lys Asn Trp Asn Thr Lys Ala Thr Cys Glu Cys Lys           
385                 390                 395                 400           

aat ggt tat atc tct gtc cag ggg gac tcc gcc tac tgt gaa gat atc       1248
Asn Gly Tyr Ile Ser Val Gln Gly Asp Ser Ala Tyr Cys Glu Asp Ile           
                405                 410                 415               

gat gag tgt gct gct aag atg cat tac tgt cgt gcc aat act gtg tgt       1296
Asp Glu Cys Ala Ala Lys Met His Tyr Cys Arg Ala Asn Thr Val Cys           
            420                 425                 430                   

gtc aac ctg cct ggg tta tat cgg tgt gac tgt gtc ccg gga tac att       1344
Val Asn Leu Pro Gly Leu Tyr Arg Cys Asp Cys Val Pro Gly Tyr Ile           
        435                 440                 445                       

cgc gtg gat gat ttc tct tgt aca gaa cat gac gaa tgt ggc agc ggg       1392
Arg Val Asp Asp Phe Ser Cys Thr Glu His Asp Glu Cys Gly Ser Gly           
    450                 455                 460                           

cag cac aac tgt gat gag aat gcc atc tgc acc aac act gtc cag gga       1440
Gln His Asn Cys Asp Glu Asn Ala Ile Cys Thr Asn Thr Val Gln Gly           
465                 470                 475                 480           

cac agc tgc acc tgc aaa ccg ggc tac gtg ggg aat ggg acc agc tgc       1488
His Ser Cys Thr Cys Lys Pro Gly Tyr Val Gly Asn Gly Thr Ser Cys           
                485                 490                 495               

aga gcg ttc tgc gaa gag ggc tgc aga tat ggc ggg aca tgc gtg gct       1536
Arg Ala Phe Cys Glu Glu Gly Cys Arg Tyr Gly Gly Thr Cys Val Ala           
            500                 505                 510                   

cct aac aaa tgt gtc tgt cct tct gga ttc aca gga agc cac tgt gag       1584
Pro Asn Lys Cys Val Cys Pro Ser Gly Phe Thr Gly Ser His Cys Glu           
        515                 520                 525                       

aaa gat att gat gaa tgt aca gag gga atc att gag tgc cac aac cat       1632
Lys Asp Ile Asp Glu Cys Thr Glu Gly Ile Ile Glu Cys His Asn His           
    530                 535                 540                           

tcc cgc tgc gtt aac ctg cca ggg tgg tac cac tgt gag tgc aga agc       1680
Ser Arg Cys Val Asn Leu Pro Gly Trp Tyr His Cys Glu Cys Arg Ser           
545                 550                 555                 560           

ggt ttc cat gac gat ggg acc tat tca ctg tcc ggg gag tcc tgt att       1728
Gly Phe His Asp Asp Gly Thr Tyr Ser Leu Ser Gly Glu Ser Cys Ile           
                565                 570                 575               

gac att gat gaa tgt gcc tta aga act cac acc tgt tgg aat gat tct       1776
Asp Ile Asp Glu Cys Ala Leu Arg Thr His Thr Cys Trp Asn Asp Ser           
            580                 585                 590                   

gcc tgc atc aac ttg gca ggg ggc ttc gac tgc ctg tgt ccc tca ggg       1824
Ala Cys Ile Asn Leu Ala Gly Gly Phe Asp Cys Leu Cys Pro Ser Gly           
        595                 600                 605                       

cca tcc tgc tct ggt gac tgc ccc cac gaa gga gga ctg aag cgc aac       1872
Pro Ser Cys Ser Gly Asp Cys Pro His Glu Gly Gly Leu Lys Arg Asn           
    610                 615                 620                           

ggg cag gtg tgg acc ctg aaa gaa gac agg tgt tct gtg tgt tcc tgc       1920
Gly Gln Val Trp Thr Leu Lys Glu Asp Arg Cys Ser Val Cys Ser Cys           
625                 630                 635                 640           

aag gat ggg aag ata ttc tgc cga cgg aca gct tgt gat tgc cag aat       1968
Lys Asp Gly Lys Ile Phe Cys Arg Arg Thr Ala Cys Asp Cys Gln Asn           
                645                 650                 655               

cca agc gtt gac ctt ttc tgt tgc cca gag tgt gac acc agg gtc aca       2016
Pro Ser Val Asp Leu Phe Cys Cys Pro Glu Cys Asp Thr Arg Val Thr           
            660                 665                 670                   

agt caa tgt tta gac caa aat gga cac aag ctc tat cga agt gga gac       2064
Ser Gln Cys Leu Asp Gln Asn Gly His Lys Leu Tyr Arg Ser Gly Asp           
        675                 680                 685                       

aat tgg act cac agc tgt cag cag tgc cgg tgt ctg gaa gga gag gta       2112
Asn Trp Thr His Ser Cys Gln Gln Cys Arg Cys Leu Glu Gly Glu Val           
    690                 695                 700                           

gat tgc tgg cca ctc act tgc ccc aga ttg agc tgt gag tac aca gcc       2160
Asp Cys Trp Pro Leu Thr Cys Pro Arg Leu Ser Cys Glu Tyr Thr Ala           
705                 710                 715                 720           

atc ttg gaa ggg gag tgt tgt cca cgc tgt gtc agc gac ccc tgc ctg       2208
Ile Leu Glu Gly Glu Cys Cys Pro Arg Cys Val Ser Asp Pro Cys Leu           
                725                 730                 735               

gcg gat aac atc gtc tat gac atc aga gaa act tgc ctg gac agc tat       2256
Ala Asp Asn Ile Val Tyr Asp Ile Arg Glu Thr Cys Leu Asp Ser Tyr           
            740                 745                 750                   

gga gtt tca agg ctt agt ggc tca gtg tgg aca ttg gct gga tct ccc       2304
Gly Val Ser Arg Leu Ser Gly Ser Val Trp Thr Leu Ala Gly Ser Pro           
        755                 760                 765                       

tgc acg acc tgc aaa tgc aag aat gga agt gtc tgc tgt tct gtg gat       2352
Cys Thr Thr Cys Lys Cys Lys Asn Gly Ser Val Cys Cys Ser Val Asp           
    770                 775                 780                           

ttg gag tgt ctt cat aat aat tga aggatttaaa atggactcat gatcgccaga      2406
Leu Glu Cys Leu His Asn Asn                                               
785                 790                                                   

gaaaaatgga caaatgacca tccatgatga tgaaagaaca ggagttggtg ttttttttac     2466

cacagacaat taccaaagtc tccgtctgag gaaggtgttt gcaggttgcc ttttggacct     2526

cccactctgc tcattcttgc taacctagtc taggtgacct acagtgcatt tcagtctatg     2586

gttgttaaaa gaagttttcc gtgttgtaaa tcacgtttcc cttaccaggt cattgcaaat     2646

acatttaaat gatttcatgg taaatgttga tgtatttttt gggtttattt tgtgtactaa     2706

cataatagag attcagctgc ttttatttat ttttttcttg acttttggat caaattcaac     2766

aaataaagtt gcctgttgtg atttt                                           2791


<210>  6
<211>  791
<212>  PRT
<213>  Equus caballus

<220>
<221>  misc_feature
<223>  NELL1 isoform 1

<400>  6

Met Gly Phe Gly Met Asp Pro Asp Leu Gln Met Asp Ile Ile Thr Glu 
1               5                   10                  15      


Leu Asp Leu Val Asn Thr Thr Leu Gly Val Thr Gln Val Ser Gly Leu 
            20                  25                  30          


His Asn Ala Ser Lys Ala Phe Leu Phe Gln Asp Val Glu Arg Glu Ile 
        35                  40                  45              


His Ala Ala Pro His Val Ser Glu Lys Leu Ile Gln Leu Phe Arg Asn 
    50                  55                  60                  


Lys Ser Glu Phe Thr Phe Leu Ala Thr Val Gln Gln Lys Pro Ser Thr 
65                  70                  75                  80  


Ser Gly Val Ile Leu Ser Ile Arg Glu Leu Glu Asn Ser Tyr Phe Glu 
                85                  90                  95      


Leu Glu Ser Ser Gly Leu Arg Asp Glu Ile Arg Tyr His Tyr Thr His 
            100                 105                 110         


Lys Gly Lys Pro Arg Thr Glu Ala Leu Pro Tyr Arg Met Ala Asp Gly 
        115                 120                 125             


Arg Trp His Lys Val Ala Leu Ser Val Ser Ala Ser His Leu Leu Leu 
    130                 135                 140                 


His Ile Asp Cys Asn Arg Ile Tyr Glu Arg Val Ile Asp Thr Pro Glu 
145                 150                 155                 160 


Thr Asn Leu Pro Pro Gly Ser Asn Leu Trp Leu Gly Gln Arg Asn Gln 
                165                 170                 175     


Lys His Gly Leu Phe Lys Gly Ile Ile Gln Asp Gly Lys Ile Ile Phe 
            180                 185                 190         


Met Pro Asn Gly Tyr Ile Thr Gln Cys Pro Asn Leu Asn Arg Thr Cys 
        195                 200                 205             


Pro Thr Cys Ser Asp Phe Leu Ser Leu Val Gln Gly Ile Met Asp Leu 
    210                 215                 220                 


Gln Glu Leu Leu Ala Lys Met Thr Ala Lys Leu Asn Tyr Ala Glu Thr 
225                 230                 235                 240 


Arg Leu Ser Gln Leu Glu Asn Cys His Cys Glu Lys Thr Cys Gln Val 
                245                 250                 255     


Ser Gly Leu Leu Tyr Arg Asp Gln Asp Ser Trp Val Asp Gly Asp His 
            260                 265                 270         


Cys Arg Asn Cys Thr Cys Lys Ser Gly Ala Val Glu Cys Arg Arg Met 
        275                 280                 285             


Ser Cys Pro Pro Leu Asn Cys Ser Pro Asp Ser Leu Pro Val His Val 
    290                 295                 300                 


Ala Gly Gln Cys Cys Lys Val Cys Arg Pro Lys Cys Ile Tyr Gly Gly 
305                 310                 315                 320 


Lys Val Leu Ala Glu Gly Gln Arg Ile Leu Thr Lys Ser Cys Arg Glu 
                325                 330                 335     


Cys Arg Gly Gly Val Leu Val Lys Ile Thr Glu Ala Cys Pro Pro Leu 
            340                 345                 350         


Asn Cys Ser Asp Lys Asp His Ile Leu Pro Glu Asn Gln Cys Cys Ser 
        355                 360                 365             


Val Cys Arg Gly His Asn Phe Cys Ala Glu Gly Pro Lys Cys Gly Glu 
    370                 375                 380                 


Asn Ser Glu Cys Lys Asn Trp Asn Thr Lys Ala Thr Cys Glu Cys Lys 
385                 390                 395                 400 


Asn Gly Tyr Ile Ser Val Gln Gly Asp Ser Ala Tyr Cys Glu Asp Ile 
                405                 410                 415     


Asp Glu Cys Ala Ala Lys Met His Tyr Cys Arg Ala Asn Thr Val Cys 
            420                 425                 430         


Val Asn Leu Pro Gly Leu Tyr Arg Cys Asp Cys Val Pro Gly Tyr Ile 
        435                 440                 445             


Arg Val Asp Asp Phe Ser Cys Thr Glu His Asp Glu Cys Gly Ser Gly 
    450                 455                 460                 


Gln His Asn Cys Asp Glu Asn Ala Ile Cys Thr Asn Thr Val Gln Gly 
465                 470                 475                 480 


His Ser Cys Thr Cys Lys Pro Gly Tyr Val Gly Asn Gly Thr Ser Cys 
                485                 490                 495     


Arg Ala Phe Cys Glu Glu Gly Cys Arg Tyr Gly Gly Thr Cys Val Ala 
            500                 505                 510         


Pro Asn Lys Cys Val Cys Pro Ser Gly Phe Thr Gly Ser His Cys Glu 
        515                 520                 525             


Lys Asp Ile Asp Glu Cys Thr Glu Gly Ile Ile Glu Cys His Asn His 
    530                 535                 540                 


Ser Arg Cys Val Asn Leu Pro Gly Trp Tyr His Cys Glu Cys Arg Ser 
545                 550                 555                 560 


Gly Phe His Asp Asp Gly Thr Tyr Ser Leu Ser Gly Glu Ser Cys Ile 
                565                 570                 575     


Asp Ile Asp Glu Cys Ala Leu Arg Thr His Thr Cys Trp Asn Asp Ser 
            580                 585                 590         


Ala Cys Ile Asn Leu Ala Gly Gly Phe Asp Cys Leu Cys Pro Ser Gly 
        595                 600                 605             


Pro Ser Cys Ser Gly Asp Cys Pro His Glu Gly Gly Leu Lys Arg Asn 
    610                 615                 620                 


Gly Gln Val Trp Thr Leu Lys Glu Asp Arg Cys Ser Val Cys Ser Cys 
625                 630                 635                 640 


Lys Asp Gly Lys Ile Phe Cys Arg Arg Thr Ala Cys Asp Cys Gln Asn 
                645                 650                 655     


Pro Ser Val Asp Leu Phe Cys Cys Pro Glu Cys Asp Thr Arg Val Thr 
            660                 665                 670         


Ser Gln Cys Leu Asp Gln Asn Gly His Lys Leu Tyr Arg Ser Gly Asp 
        675                 680                 685             


Asn Trp Thr His Ser Cys Gln Gln Cys Arg Cys Leu Glu Gly Glu Val 
    690                 695                 700                 


Asp Cys Trp Pro Leu Thr Cys Pro Arg Leu Ser Cys Glu Tyr Thr Ala 
705                 710                 715                 720 


Ile Leu Glu Gly Glu Cys Cys Pro Arg Cys Val Ser Asp Pro Cys Leu 
                725                 730                 735     


Ala Asp Asn Ile Val Tyr Asp Ile Arg Glu Thr Cys Leu Asp Ser Tyr 
            740                 745                 750         


Gly Val Ser Arg Leu Ser Gly Ser Val Trp Thr Leu Ala Gly Ser Pro 
        755                 760                 765             


Cys Thr Thr Cys Lys Cys Lys Asn Gly Ser Val Cys Cys Ser Val Asp 
    770                 775                 780                 


Leu Glu Cys Leu His Asn Asn 
785                 790     


<210>  7
<211>  2285
<212>  DNA
<213>  Equus caballus


<220>
<221>  misc_feature
<223>  NELL1 isoform 2

<220>
<221>  CDS
<222>  (1)..(2235)

<400>  7
atg ggc ttt ggg atg gac ccc gac ctt caa atg gat att atc acc gag         48
Met Gly Phe Gly Met Asp Pro Asp Leu Gln Met Asp Ile Ile Thr Glu           
1               5                   10                  15                

ctc gac ctc gtg aac acc acc ctt gga gtc act cag gtg tcc gga ctg         96
Leu Asp Leu Val Asn Thr Thr Leu Gly Val Thr Gln Val Ser Gly Leu           
            20                  25                  30                    

cac aat gcc agc aaa gca ttt tta ttt caa gat gta gag aga gag atc        144
His Asn Ala Ser Lys Ala Phe Leu Phe Gln Asp Val Glu Arg Glu Ile           
        35                  40                  45                        

cat gca gcc cca cac gtg agt gag aaa tta att cag ctg ttc cgg aat        192
His Ala Ala Pro His Val Ser Glu Lys Leu Ile Gln Leu Phe Arg Asn           
    50                  55                  60                            

aag agt gaa ttc acc ttt ttg gcc act gtg cag cag aag ccg tca act        240
Lys Ser Glu Phe Thr Phe Leu Ala Thr Val Gln Gln Lys Pro Ser Thr           
65                  70                  75                  80            

tca gga gtg ata ctg tcc att cga gaa ctg gaa aac agt tat ttt gaa        288
Ser Gly Val Ile Leu Ser Ile Arg Glu Leu Glu Asn Ser Tyr Phe Glu           
                85                  90                  95                

ctg gag agc agt ggc ctg aga gat gag att cga tat cac tac aca cac        336
Leu Glu Ser Ser Gly Leu Arg Asp Glu Ile Arg Tyr His Tyr Thr His           
            100                 105                 110                   

aag ggg aag ccc agg aca gag gca ctt ccc tac cgg atg gcg gac gga        384
Lys Gly Lys Pro Arg Thr Glu Ala Leu Pro Tyr Arg Met Ala Asp Gly           
        115                 120                 125                       

cgg tgg cac aag gtg gcg ctg tca gtt agc gcc tct cat ctc ctg ctc        432
Arg Trp His Lys Val Ala Leu Ser Val Ser Ala Ser His Leu Leu Leu           
    130                 135                 140                           

cac atc gac tgc aac agg att tat gaa cgt gtg ata gac act cct gag        480
His Ile Asp Cys Asn Arg Ile Tyr Glu Arg Val Ile Asp Thr Pro Glu           
145                 150                 155                 160           

acc aac ctc ccc cca gga agc aat ttg tgg ctg ggt cag cga aac caa        528
Thr Asn Leu Pro Pro Gly Ser Asn Leu Trp Leu Gly Gln Arg Asn Gln           
                165                 170                 175               

aag cac ggc tta ttc aaa gga atc atc caa gat gga aaa atc atc ttc        576
Lys His Gly Leu Phe Lys Gly Ile Ile Gln Asp Gly Lys Ile Ile Phe           
            180                 185                 190                   

atg ccg aat gga tac ata aca cag tgt ccg aac ctg aat cgc act tgc        624
Met Pro Asn Gly Tyr Ile Thr Gln Cys Pro Asn Leu Asn Arg Thr Cys           
        195                 200                 205                       

cca acg tgc agt gat ttc tta agc ctg gtg caa gga atc atg gat tta        672
Pro Thr Cys Ser Asp Phe Leu Ser Leu Val Gln Gly Ile Met Asp Leu           
    210                 215                 220                           

caa gag ctt ctg gcc aag atg act gcg aaa cta aat tat gca gag aca        720
Gln Glu Leu Leu Ala Lys Met Thr Ala Lys Leu Asn Tyr Ala Glu Thr           
225                 230                 235                 240           

cga ctt agt caa ttg gaa aac tgc cac tgc gag aag acc tgt caa gtg        768
Arg Leu Ser Gln Leu Glu Asn Cys His Cys Glu Lys Thr Cys Gln Val           
                245                 250                 255               

agt gga ctg ctc tat aga gac cag gac tcc tgg gtt gat ggc gat cac        816
Ser Gly Leu Leu Tyr Arg Asp Gln Asp Ser Trp Val Asp Gly Asp His           
            260                 265                 270                   

tgt agg aac tgc acg tgc aaa agc ggc gct gtg gaa tgt cgg agg atg        864
Cys Arg Asn Cys Thr Cys Lys Ser Gly Ala Val Glu Cys Arg Arg Met           
        275                 280                 285                       

tct tgt ccc cct ctc aat tgc tcc cca gac tcc ctc cct gtg cac gtt        912
Ser Cys Pro Pro Leu Asn Cys Ser Pro Asp Ser Leu Pro Val His Val           
    290                 295                 300                           

gcc ggc cag tgc tgt aag gtc tgc cga cca aaa tgt atc tac gga ggg        960
Ala Gly Gln Cys Cys Lys Val Cys Arg Pro Lys Cys Ile Tyr Gly Gly           
305                 310                 315                 320           

aaa gtc ctt gca gaa ggc cag cgg att tta acc aag agc tgt cgg gaa       1008
Lys Val Leu Ala Glu Gly Gln Arg Ile Leu Thr Lys Ser Cys Arg Glu           
                325                 330                 335               

tgc cga ggt gga gtt tta gtg aaa att aca gaa gcg tgc cct cct ttg       1056
Cys Arg Gly Gly Val Leu Val Lys Ile Thr Glu Ala Cys Pro Pro Leu           
            340                 345                 350                   

aac tgc tca gac aag gat cac att ctc cca gag aat cag tgc tgc agc       1104
Asn Cys Ser Asp Lys Asp His Ile Leu Pro Glu Asn Gln Cys Cys Ser           
        355                 360                 365                       

gtc tgc aga ggt cat aac ttt tgt gcg gaa gga cct aaa tgt ggt gaa       1152
Val Cys Arg Gly His Asn Phe Cys Ala Glu Gly Pro Lys Cys Gly Glu           
    370                 375                 380                           

aat tca gag tgc aaa aac tgg aat aca aaa gct act tgc gag tgc aag       1200
Asn Ser Glu Cys Lys Asn Trp Asn Thr Lys Ala Thr Cys Glu Cys Lys           
385                 390                 395                 400           

aat ggt tat atc tct gtc cag ggg gac tcc gcc tac tgt gaa gat atc       1248
Asn Gly Tyr Ile Ser Val Gln Gly Asp Ser Ala Tyr Cys Glu Asp Ile           
                405                 410                 415               

gat gag tgt gct gct aag atg cat tac tgt cgt gcc aat act gtg tgt       1296
Asp Glu Cys Ala Ala Lys Met His Tyr Cys Arg Ala Asn Thr Val Cys           
            420                 425                 430                   

gtc aac ctg cct ggg tta tat cgg tgt gac tgt gtc ccg gga tac att       1344
Val Asn Leu Pro Gly Leu Tyr Arg Cys Asp Cys Val Pro Gly Tyr Ile           
        435                 440                 445                       

cgc gtg gat gat ttc tct tgt aca gaa cat gac gaa tgt ggc agc ggg       1392
Arg Val Asp Asp Phe Ser Cys Thr Glu His Asp Glu Cys Gly Ser Gly           
    450                 455                 460                           

cag cac aac tgt gat gag aat gcc atc tgc acc aac act gtc cag gga       1440
Gln His Asn Cys Asp Glu Asn Ala Ile Cys Thr Asn Thr Val Gln Gly           
465                 470                 475                 480           

cac agc tgc acc tgc aaa ccg ggc tac gtg ggg aat ggg acc agc tgc       1488
His Ser Cys Thr Cys Lys Pro Gly Tyr Val Gly Asn Gly Thr Ser Cys           
                485                 490                 495               

aga gcg ttc tgc gaa gag ggc tgc aga tat ggc ggg aca tgc gtg gct       1536
Arg Ala Phe Cys Glu Glu Gly Cys Arg Tyr Gly Gly Thr Cys Val Ala           
            500                 505                 510                   

cct aac aaa tgt gtc tgt cct tct gga ttc aca gga agc cac tgt gag       1584
Pro Asn Lys Cys Val Cys Pro Ser Gly Phe Thr Gly Ser His Cys Glu           
        515                 520                 525                       

aaa gac att gat gaa tgt gcc tta aga act cac acc tgt tgg aat gat       1632
Lys Asp Ile Asp Glu Cys Ala Leu Arg Thr His Thr Cys Trp Asn Asp           
    530                 535                 540                           

tct gcc tgc atc aac ttg gca ggg ggc ttc gac tgc ctg tgt ccc tca       1680
Ser Ala Cys Ile Asn Leu Ala Gly Gly Phe Asp Cys Leu Cys Pro Ser           
545                 550                 555                 560           

ggg cca tcc tgc tct ggt gac tgc ccc cac gaa gga gga ctg aag cgc       1728
Gly Pro Ser Cys Ser Gly Asp Cys Pro His Glu Gly Gly Leu Lys Arg           
                565                 570                 575               

aac ggg cag gtg tgg acc ctg aaa gaa gac agg tgt tct gtg tgt tcc       1776
Asn Gly Gln Val Trp Thr Leu Lys Glu Asp Arg Cys Ser Val Cys Ser           
            580                 585                 590                   

tgc aag gat ggg aag ata ttc tgc cga cgg aca gct tgt gat tgc cag       1824
Cys Lys Asp Gly Lys Ile Phe Cys Arg Arg Thr Ala Cys Asp Cys Gln           
        595                 600                 605                       

aat cca agc gtt gac ctt ttc tgt tgc cca gag tgt gac acc agg gtc       1872
Asn Pro Ser Val Asp Leu Phe Cys Cys Pro Glu Cys Asp Thr Arg Val           
    610                 615                 620                           

aca agt caa tgt tta gac caa aat gga cac aag ctc tat cga agt gga       1920
Thr Ser Gln Cys Leu Asp Gln Asn Gly His Lys Leu Tyr Arg Ser Gly           
625                 630                 635                 640           

gac aat tgg act cac agc tgt cag cag tgc cgg tgt ctg gaa gga gag       1968
Asp Asn Trp Thr His Ser Cys Gln Gln Cys Arg Cys Leu Glu Gly Glu           
                645                 650                 655               

gta gat tgc tgg cca ctc act tgc ccc aga ttg agc tgt gag tac aca       2016
Val Asp Cys Trp Pro Leu Thr Cys Pro Arg Leu Ser Cys Glu Tyr Thr           
            660                 665                 670                   

gcc atc ttg gaa ggg gag tgt tgt cca cgc tgt gtc agc gac ccc tgc       2064
Ala Ile Leu Glu Gly Glu Cys Cys Pro Arg Cys Val Ser Asp Pro Cys           
        675                 680                 685                       

ctg gcg gat aac atc gtc tat gac atc aga gaa act tgc ctg gac agc       2112
Leu Ala Asp Asn Ile Val Tyr Asp Ile Arg Glu Thr Cys Leu Asp Ser           
    690                 695                 700                           

tat gga gtt tca agg ctt agt ggc tca gtg tgg aca ttg gct gga tct       2160
Tyr Gly Val Ser Arg Leu Ser Gly Ser Val Trp Thr Leu Ala Gly Ser           
705                 710                 715                 720           

ccc tgc acg acc tgc aaa tgc aag aat gga agt gtc tgc tgt tct gtg       2208
Pro Cys Thr Thr Cys Lys Cys Lys Asn Gly Ser Val Cys Cys Ser Val           
                725                 730                 735               

gat ttg gag tgt ctt cat aat aat tga aggatttaaa atggactcat             2255
Asp Leu Glu Cys Leu His Asn Asn                                           
            740                                                           

gatcgccaga gaaaaatgga caaatgacca                                      2285


<210>  8
<211>  744
<212>  PRT
<213>  Equus caballus

<220>
<221>  misc_feature
<223>  NELL1 isoform 2

<400>  8

Met Gly Phe Gly Met Asp Pro Asp Leu Gln Met Asp Ile Ile Thr Glu 
1               5                   10                  15      


Leu Asp Leu Val Asn Thr Thr Leu Gly Val Thr Gln Val Ser Gly Leu 
            20                  25                  30          


His Asn Ala Ser Lys Ala Phe Leu Phe Gln Asp Val Glu Arg Glu Ile 
        35                  40                  45              


His Ala Ala Pro His Val Ser Glu Lys Leu Ile Gln Leu Phe Arg Asn 
    50                  55                  60                  


Lys Ser Glu Phe Thr Phe Leu Ala Thr Val Gln Gln Lys Pro Ser Thr 
65                  70                  75                  80  


Ser Gly Val Ile Leu Ser Ile Arg Glu Leu Glu Asn Ser Tyr Phe Glu 
                85                  90                  95      


Leu Glu Ser Ser Gly Leu Arg Asp Glu Ile Arg Tyr His Tyr Thr His 
            100                 105                 110         


Lys Gly Lys Pro Arg Thr Glu Ala Leu Pro Tyr Arg Met Ala Asp Gly 
        115                 120                 125             


Arg Trp His Lys Val Ala Leu Ser Val Ser Ala Ser His Leu Leu Leu 
    130                 135                 140                 


His Ile Asp Cys Asn Arg Ile Tyr Glu Arg Val Ile Asp Thr Pro Glu 
145                 150                 155                 160 


Thr Asn Leu Pro Pro Gly Ser Asn Leu Trp Leu Gly Gln Arg Asn Gln 
                165                 170                 175     


Lys His Gly Leu Phe Lys Gly Ile Ile Gln Asp Gly Lys Ile Ile Phe 
            180                 185                 190         


Met Pro Asn Gly Tyr Ile Thr Gln Cys Pro Asn Leu Asn Arg Thr Cys 
        195                 200                 205             


Pro Thr Cys Ser Asp Phe Leu Ser Leu Val Gln Gly Ile Met Asp Leu 
    210                 215                 220                 


Gln Glu Leu Leu Ala Lys Met Thr Ala Lys Leu Asn Tyr Ala Glu Thr 
225                 230                 235                 240 


Arg Leu Ser Gln Leu Glu Asn Cys His Cys Glu Lys Thr Cys Gln Val 
                245                 250                 255     


Ser Gly Leu Leu Tyr Arg Asp Gln Asp Ser Trp Val Asp Gly Asp His 
            260                 265                 270         


Cys Arg Asn Cys Thr Cys Lys Ser Gly Ala Val Glu Cys Arg Arg Met 
        275                 280                 285             


Ser Cys Pro Pro Leu Asn Cys Ser Pro Asp Ser Leu Pro Val His Val 
    290                 295                 300                 


Ala Gly Gln Cys Cys Lys Val Cys Arg Pro Lys Cys Ile Tyr Gly Gly 
305                 310                 315                 320 


Lys Val Leu Ala Glu Gly Gln Arg Ile Leu Thr Lys Ser Cys Arg Glu 
                325                 330                 335     


Cys Arg Gly Gly Val Leu Val Lys Ile Thr Glu Ala Cys Pro Pro Leu 
            340                 345                 350         


Asn Cys Ser Asp Lys Asp His Ile Leu Pro Glu Asn Gln Cys Cys Ser 
        355                 360                 365             


Val Cys Arg Gly His Asn Phe Cys Ala Glu Gly Pro Lys Cys Gly Glu 
    370                 375                 380                 


Asn Ser Glu Cys Lys Asn Trp Asn Thr Lys Ala Thr Cys Glu Cys Lys 
385                 390                 395                 400 


Asn Gly Tyr Ile Ser Val Gln Gly Asp Ser Ala Tyr Cys Glu Asp Ile 
                405                 410                 415     


Asp Glu Cys Ala Ala Lys Met His Tyr Cys Arg Ala Asn Thr Val Cys 
            420                 425                 430         


Val Asn Leu Pro Gly Leu Tyr Arg Cys Asp Cys Val Pro Gly Tyr Ile 
        435                 440                 445             


Arg Val Asp Asp Phe Ser Cys Thr Glu His Asp Glu Cys Gly Ser Gly 
    450                 455                 460                 


Gln His Asn Cys Asp Glu Asn Ala Ile Cys Thr Asn Thr Val Gln Gly 
465                 470                 475                 480 


His Ser Cys Thr Cys Lys Pro Gly Tyr Val Gly Asn Gly Thr Ser Cys 
                485                 490                 495     


Arg Ala Phe Cys Glu Glu Gly Cys Arg Tyr Gly Gly Thr Cys Val Ala 
            500                 505                 510         


Pro Asn Lys Cys Val Cys Pro Ser Gly Phe Thr Gly Ser His Cys Glu 
        515                 520                 525             


Lys Asp Ile Asp Glu Cys Ala Leu Arg Thr His Thr Cys Trp Asn Asp 
    530                 535                 540                 


Ser Ala Cys Ile Asn Leu Ala Gly Gly Phe Asp Cys Leu Cys Pro Ser 
545                 550                 555                 560 


Gly Pro Ser Cys Ser Gly Asp Cys Pro His Glu Gly Gly Leu Lys Arg 
                565                 570                 575     


Asn Gly Gln Val Trp Thr Leu Lys Glu Asp Arg Cys Ser Val Cys Ser 
            580                 585                 590         


Cys Lys Asp Gly Lys Ile Phe Cys Arg Arg Thr Ala Cys Asp Cys Gln 
        595                 600                 605             


Asn Pro Ser Val Asp Leu Phe Cys Cys Pro Glu Cys Asp Thr Arg Val 
    610                 615                 620                 


Thr Ser Gln Cys Leu Asp Gln Asn Gly His Lys Leu Tyr Arg Ser Gly 
625                 630                 635                 640 


Asp Asn Trp Thr His Ser Cys Gln Gln Cys Arg Cys Leu Glu Gly Glu 
                645                 650                 655     


Val Asp Cys Trp Pro Leu Thr Cys Pro Arg Leu Ser Cys Glu Tyr Thr 
            660                 665                 670         


Ala Ile Leu Glu Gly Glu Cys Cys Pro Arg Cys Val Ser Asp Pro Cys 
        675                 680                 685             


Leu Ala Asp Asn Ile Val Tyr Asp Ile Arg Glu Thr Cys Leu Asp Ser 
    690                 695                 700                 


Tyr Gly Val Ser Arg Leu Ser Gly Ser Val Trp Thr Leu Ala Gly Ser 
705                 710                 715                 720 


Pro Cys Thr Thr Cys Lys Cys Lys Asn Gly Ser Val Cys Cys Ser Val 
                725                 730                 735     


Asp Leu Glu Cys Leu His Asn Asn 
            740                 


<210>  9
<211>  2812
<212>  DNA
<213>  Mus musculus


<220>
<221>  misc_feature
<223>  NELL1

<220>
<221>  CDS
<222>  (40)..(2472)

<400>  9
gcgttggtgc gccctgcttg gcggggggcc tccggagcg atg ccg atg gat gtg          54
                                           Met Pro Met Asp Val            
                                           1               5              

att tta gtt ttg tgg ttc tgt gtg tgc acc gcc agg aca gtg ctg ggc        102
Ile Leu Val Leu Trp Phe Cys Val Cys Thr Ala Arg Thr Val Leu Gly           
                10                  15                  20                

ttt ggg atg gac cct gac ctt cag atg gac atc atc act gaa ctt gac        150
Phe Gly Met Asp Pro Asp Leu Gln Met Asp Ile Ile Thr Glu Leu Asp           
            25                  30                  35                    

ctt gtg aac acc acc ctg ggc gtc act cag gtg gct gga cta cac aat        198
Leu Val Asn Thr Thr Leu Gly Val Thr Gln Val Ala Gly Leu His Asn           
        40                  45                  50                        

gcc agt aag gca ttt ctg ttt caa gat gta cag aga gag atc cac tca        246
Ala Ser Lys Ala Phe Leu Phe Gln Asp Val Gln Arg Glu Ile His Ser           
    55                  60                  65                            

gcc cct cat gtg agt gag aag ctg atc cag cta ttc cgg aat aag agt        294
Ala Pro His Val Ser Glu Lys Leu Ile Gln Leu Phe Arg Asn Lys Ser           
70                  75                  80                  85            

gag ttt acc ttt ttg gct aca gtg cag cag aag ccg tcc acc tca ggg        342
Glu Phe Thr Phe Leu Ala Thr Val Gln Gln Lys Pro Ser Thr Ser Gly           
                90                  95                  100               

gtg ata ctg tcg atc cgg gag ctg gaa cac agc tat ttt gaa ctg gag        390
Val Ile Leu Ser Ile Arg Glu Leu Glu His Ser Tyr Phe Glu Leu Glu           
            105                 110                 115                   

agc agt ggc cca aga gaa gag ata cgc tat cat tac atc cat ggc ggc        438
Ser Ser Gly Pro Arg Glu Glu Ile Arg Tyr His Tyr Ile His Gly Gly           
        120                 125                 130                       

aag ccc agg act gag gcc ctt ccc tac cgc atg gcc gat gga cag tgg        486
Lys Pro Arg Thr Glu Ala Leu Pro Tyr Arg Met Ala Asp Gly Gln Trp           
    135                 140                 145                           

cac aag gtc gcg ctg tct gtg agc gcc tct cac ctc cta ctc cat gtc        534
His Lys Val Ala Leu Ser Val Ser Ala Ser His Leu Leu Leu His Val           
150                 155                 160                 165           

gac tgc aat agg att tat gag cgt gtg ata gat cct ccg gag acc aac        582
Asp Cys Asn Arg Ile Tyr Glu Arg Val Ile Asp Pro Pro Glu Thr Asn           
                170                 175                 180               

ctt cct cca gga agc aat cta tgg ctt ggg caa cgt aat caa aag cat        630
Leu Pro Pro Gly Ser Asn Leu Trp Leu Gly Gln Arg Asn Gln Lys His           
            185                 190                 195                   

ggc ttt ttc aaa gga atc atc caa gat ggc aag atc atc ttc atg ccg        678
Gly Phe Phe Lys Gly Ile Ile Gln Asp Gly Lys Ile Ile Phe Met Pro           
        200                 205                 210                       

aac ggc ttc atc aca cag tgc ccc aac cta aat cgc act tgc cca aca        726
Asn Gly Phe Ile Thr Gln Cys Pro Asn Leu Asn Arg Thr Cys Pro Thr           
    215                 220                 225                           

tgc agt gat ttc ctg agc ctg gtt caa gga ata atg gat ttg caa gag        774
Cys Ser Asp Phe Leu Ser Leu Val Gln Gly Ile Met Asp Leu Gln Glu           
230                 235                 240                 245           

ctt ttg gcc aag atg act gca aaa ctg aat tat gca gag acg aga ctt        822
Leu Leu Ala Lys Met Thr Ala Lys Leu Asn Tyr Ala Glu Thr Arg Leu           
                250                 255                 260               

ggt caa ctg gaa aat tgc cac tgt gag aag acc tgc caa gtg agt ggg        870
Gly Gln Leu Glu Asn Cys His Cys Glu Lys Thr Cys Gln Val Ser Gly           
            265                 270                 275                   

ctg ctc tac agg gac caa gac tcc tgg gta gat ggt gac aac tgc agg        918
Leu Leu Tyr Arg Asp Gln Asp Ser Trp Val Asp Gly Asp Asn Cys Arg           
        280                 285                 290                       

aac tgc aca tgc aaa agt ggt gct gtg gag tgc cga agg atg tcc tgt        966
Asn Cys Thr Cys Lys Ser Gly Ala Val Glu Cys Arg Arg Met Ser Cys           
    295                 300                 305                           

ccc cca ctc aac tgt tcc cca gac tca ctt cct gtg cat att tct ggc       1014
Pro Pro Leu Asn Cys Ser Pro Asp Ser Leu Pro Val His Ile Ser Gly           
310                 315                 320                 325           

caa tgt tgt aaa gtt tgc aga cca aaa tgt atc tat gga gga aaa gtt       1062
Gln Cys Cys Lys Val Cys Arg Pro Lys Cys Ile Tyr Gly Gly Lys Val           
                330                 335                 340               

ctt gct gag ggc cag cgg att tta acc aag acc tgc cgg gaa tgt cga       1110
Leu Ala Glu Gly Gln Arg Ile Leu Thr Lys Thr Cys Arg Glu Cys Arg           
            345                 350                 355                   

ggt gga gtc ttg gta aaa atc aca gaa gct tgc cct cct ttg aac tgc       1158
Gly Gly Val Leu Val Lys Ile Thr Glu Ala Cys Pro Pro Leu Asn Cys           
        360                 365                 370                       

tca gag aag gat cat att ctt ccg gag aac cag tgc tgc agg gtc tgc       1206
Ser Glu Lys Asp His Ile Leu Pro Glu Asn Gln Cys Cys Arg Val Cys           
    375                 380                 385                           

cga ggt cat aac ttc tgt gca gaa gca cct aag tgt gga gaa aac tcg       1254
Arg Gly His Asn Phe Cys Ala Glu Ala Pro Lys Cys Gly Glu Asn Ser           
390                 395                 400                 405           

gaa tgc aaa aat tgg aat aca aaa gcg act tgt gag tgc aag aat gga       1302
Glu Cys Lys Asn Trp Asn Thr Lys Ala Thr Cys Glu Cys Lys Asn Gly           
                410                 415                 420               

tac atc tct gtc cag ggc aac tct gca tac tgt gaa gat atc gat gag       1350
Tyr Ile Ser Val Gln Gly Asn Ser Ala Tyr Cys Glu Asp Ile Asp Glu           
            425                 430                 435                   

tgt gca gca aag atg cac tac tgt cat gcc aac acg gtg tgt gtc aac       1398
Cys Ala Ala Lys Met His Tyr Cys His Ala Asn Thr Val Cys Val Asn           
        440                 445                 450                       

ttg ccg ggg tta tat cgc tgt gac tgc atc cca gga tac atc cgt gtg       1446
Leu Pro Gly Leu Tyr Arg Cys Asp Cys Ile Pro Gly Tyr Ile Arg Val           
    455                 460                 465                           

gat gac ttc tct tgt acg gag cat gat gat tgt ggc agc gga caa cac       1494
Asp Asp Phe Ser Cys Thr Glu His Asp Asp Cys Gly Ser Gly Gln His           
470                 475                 480                 485           

aac tgt gac aaa aat gcc atc tgt acc aac aca gtc cag gga cac agc       1542
Asn Cys Asp Lys Asn Ala Ile Cys Thr Asn Thr Val Gln Gly His Ser           
                490                 495                 500               

tgt acc tgc cag cca ggc tac gtg gga aat ggt act gtc tgc aaa gca       1590
Cys Thr Cys Gln Pro Gly Tyr Val Gly Asn Gly Thr Val Cys Lys Ala           
            505                 510                 515                   

ttc tgt gaa gag ggt tgc aga tac gga ggt acc tgt gtg gcc cct aac       1638
Phe Cys Glu Glu Gly Cys Arg Tyr Gly Gly Thr Cys Val Ala Pro Asn           
        520                 525                 530                       

aaa tgt gtc tgt cct tct gga ttc aca gga agc cac tgt gag aaa gat       1686
Lys Cys Val Cys Pro Ser Gly Phe Thr Gly Ser His Cys Glu Lys Asp           
    535                 540                 545                           

att gat gaa tgt gca gag gga ttc gtt gag tgc cac aac cac tcc cgc       1734
Ile Asp Glu Cys Ala Glu Gly Phe Val Glu Cys His Asn His Ser Arg           
550                 555                 560                 565           

tgc gtt aac ctt cca ggg tgg tac cac tgt gag tgc aga agc ggt ttc       1782
Cys Val Asn Leu Pro Gly Trp Tyr His Cys Glu Cys Arg Ser Gly Phe           
                570                 575                 580               

cat gac gat ggg acc tat tca ctg tcc ggg gag tcc tgc att gat att       1830
His Asp Asp Gly Thr Tyr Ser Leu Ser Gly Glu Ser Cys Ile Asp Ile           
            585                 590                 595                   

gat gaa tgt gcc tta aga act cac act tgt tgg aat gac tct gcc tgc       1878
Asp Glu Cys Ala Leu Arg Thr His Thr Cys Trp Asn Asp Ser Ala Cys           
        600                 605                 610                       

atc aac tta gca gga gga ttt gac tgc ctg tgt ccc tct ggg ccc tcc       1926
Ile Asn Leu Ala Gly Gly Phe Asp Cys Leu Cys Pro Ser Gly Pro Ser           
    615                 620                 625                           

tgc tct ggt gac tgt ccc cac gaa ggg ggg ctg aag cat aat ggg cag       1974
Cys Ser Gly Asp Cys Pro His Glu Gly Gly Leu Lys His Asn Gly Gln           
630                 635                 640                 645           

gtg tgg att ctg aga gaa gac agg tgt tca gtc tgt tcc tgt aag gat       2022
Val Trp Ile Leu Arg Glu Asp Arg Cys Ser Val Cys Ser Cys Lys Asp           
                650                 655                 660               

ggg aag ata ttc tgc cgg cgg aca gct tgt gat tgc cag aat cca aat       2070
Gly Lys Ile Phe Cys Arg Arg Thr Ala Cys Asp Cys Gln Asn Pro Asn           
            665                 670                 675                   

gtt gac ctt ttc tgc tgc cca gag tgt gac acc agg gtc act agc caa       2118
Val Asp Leu Phe Cys Cys Pro Glu Cys Asp Thr Arg Val Thr Ser Gln           
        680                 685                 690                       

tgt tta gat caa agc gga cag aag ctc tat cga agt gga gac aac tgg       2166
Cys Leu Asp Gln Ser Gly Gln Lys Leu Tyr Arg Ser Gly Asp Asn Trp           
    695                 700                 705                           

acc cac agc tgc cag cag tgc cga tgt ctg gaa gga gag gca gac tgc       2214
Thr His Ser Cys Gln Gln Cys Arg Cys Leu Glu Gly Glu Ala Asp Cys           
710                 715                 720                 725           

tgg cct cta gct tgc cct agt ttg agc tgt gaa tac aca gcc atc ttt       2262
Trp Pro Leu Ala Cys Pro Ser Leu Ser Cys Glu Tyr Thr Ala Ile Phe           
                730                 735                 740               

gaa gga gag tgt tgt ccc cgc tgt gtc agt gac ccc tgc ctg gct gat       2310
Glu Gly Glu Cys Cys Pro Arg Cys Val Ser Asp Pro Cys Leu Ala Asp           
            745                 750                 755                   

aat att gcc tat gac atc aga aaa act tgc ctg gac agc tct ggt att       2358
Asn Ile Ala Tyr Asp Ile Arg Lys Thr Cys Leu Asp Ser Ser Gly Ile           
        760                 765                 770                       

tcg agg ctg agc ggc gca gtg tgg aca atg gct gga tct ccc tgt aca       2406
Ser Arg Leu Ser Gly Ala Val Trp Thr Met Ala Gly Ser Pro Cys Thr           
    775                 780                 785                           

acc tgt caa tgc aag aat ggg aga gtc tgc tgc tct gtg gat ctg gtg       2454
Thr Cys Gln Cys Lys Asn Gly Arg Val Cys Cys Ser Val Asp Leu Val           
790                 795                 800                 805           

tgt ctt gag aat aac tga agattttaaa tggactcatc acatgagaaa              2502
Cys Leu Glu Asn Asn                                                       
                810                                                       

atggacaaaa tgaccatcca acctgaggaa gaggaggggc tgatttcttt ttctttttaa     2562

ccacagtcaa ttaccaaagt ctccatcaga ggaaggcgtt tgggttgcct ttaccacttt     2622

gctcatcctt gctgacctag tctagatgcc tgcagtaccg tgtatttcgg tcgatggttg     2682

ttgagtctcc gtgctgtaaa tcacatttcc cttgtcagat catttacaga tacatttaaa     2742

ggattccatg ataaatgtta aagtaccttt tgtttatttt gtgtaccaac ataatagaga     2802

cttggcacca                                                            2812


<210>  10
<211>  810
<212>  PRT
<213>  Mus musculus

<220>
<221>  misc_feature
<223>  NELL1

<400>  10

Met Pro Met Asp Val Ile Leu Val Leu Trp Phe Cys Val Cys Thr Ala 
1               5                   10                  15      


Arg Thr Val Leu Gly Phe Gly Met Asp Pro Asp Leu Gln Met Asp Ile 
            20                  25                  30          


Ile Thr Glu Leu Asp Leu Val Asn Thr Thr Leu Gly Val Thr Gln Val 
        35                  40                  45              


Ala Gly Leu His Asn Ala Ser Lys Ala Phe Leu Phe Gln Asp Val Gln 
    50                  55                  60                  


Arg Glu Ile His Ser Ala Pro His Val Ser Glu Lys Leu Ile Gln Leu 
65                  70                  75                  80  


Phe Arg Asn Lys Ser Glu Phe Thr Phe Leu Ala Thr Val Gln Gln Lys 
                85                  90                  95      


Pro Ser Thr Ser Gly Val Ile Leu Ser Ile Arg Glu Leu Glu His Ser 
            100                 105                 110         


Tyr Phe Glu Leu Glu Ser Ser Gly Pro Arg Glu Glu Ile Arg Tyr His 
        115                 120                 125             


Tyr Ile His Gly Gly Lys Pro Arg Thr Glu Ala Leu Pro Tyr Arg Met 
    130                 135                 140                 


Ala Asp Gly Gln Trp His Lys Val Ala Leu Ser Val Ser Ala Ser His 
145                 150                 155                 160 


Leu Leu Leu His Val Asp Cys Asn Arg Ile Tyr Glu Arg Val Ile Asp 
                165                 170                 175     


Pro Pro Glu Thr Asn Leu Pro Pro Gly Ser Asn Leu Trp Leu Gly Gln 
            180                 185                 190         


Arg Asn Gln Lys His Gly Phe Phe Lys Gly Ile Ile Gln Asp Gly Lys 
        195                 200                 205             


Ile Ile Phe Met Pro Asn Gly Phe Ile Thr Gln Cys Pro Asn Leu Asn 
    210                 215                 220                 


Arg Thr Cys Pro Thr Cys Ser Asp Phe Leu Ser Leu Val Gln Gly Ile 
225                 230                 235                 240 


Met Asp Leu Gln Glu Leu Leu Ala Lys Met Thr Ala Lys Leu Asn Tyr 
                245                 250                 255     


Ala Glu Thr Arg Leu Gly Gln Leu Glu Asn Cys His Cys Glu Lys Thr 
            260                 265                 270         


Cys Gln Val Ser Gly Leu Leu Tyr Arg Asp Gln Asp Ser Trp Val Asp 
        275                 280                 285             


Gly Asp Asn Cys Arg Asn Cys Thr Cys Lys Ser Gly Ala Val Glu Cys 
    290                 295                 300                 


Arg Arg Met Ser Cys Pro Pro Leu Asn Cys Ser Pro Asp Ser Leu Pro 
305                 310                 315                 320 


Val His Ile Ser Gly Gln Cys Cys Lys Val Cys Arg Pro Lys Cys Ile 
                325                 330                 335     


Tyr Gly Gly Lys Val Leu Ala Glu Gly Gln Arg Ile Leu Thr Lys Thr 
            340                 345                 350         


Cys Arg Glu Cys Arg Gly Gly Val Leu Val Lys Ile Thr Glu Ala Cys 
        355                 360                 365             


Pro Pro Leu Asn Cys Ser Glu Lys Asp His Ile Leu Pro Glu Asn Gln 
    370                 375                 380                 


Cys Cys Arg Val Cys Arg Gly His Asn Phe Cys Ala Glu Ala Pro Lys 
385                 390                 395                 400 


Cys Gly Glu Asn Ser Glu Cys Lys Asn Trp Asn Thr Lys Ala Thr Cys 
                405                 410                 415     


Glu Cys Lys Asn Gly Tyr Ile Ser Val Gln Gly Asn Ser Ala Tyr Cys 
            420                 425                 430         


Glu Asp Ile Asp Glu Cys Ala Ala Lys Met His Tyr Cys His Ala Asn 
        435                 440                 445             


Thr Val Cys Val Asn Leu Pro Gly Leu Tyr Arg Cys Asp Cys Ile Pro 
    450                 455                 460                 


Gly Tyr Ile Arg Val Asp Asp Phe Ser Cys Thr Glu His Asp Asp Cys 
465                 470                 475                 480 


Gly Ser Gly Gln His Asn Cys Asp Lys Asn Ala Ile Cys Thr Asn Thr 
                485                 490                 495     


Val Gln Gly His Ser Cys Thr Cys Gln Pro Gly Tyr Val Gly Asn Gly 
            500                 505                 510         


Thr Val Cys Lys Ala Phe Cys Glu Glu Gly Cys Arg Tyr Gly Gly Thr 
        515                 520                 525             


Cys Val Ala Pro Asn Lys Cys Val Cys Pro Ser Gly Phe Thr Gly Ser 
    530                 535                 540                 


His Cys Glu Lys Asp Ile Asp Glu Cys Ala Glu Gly Phe Val Glu Cys 
545                 550                 555                 560 


His Asn His Ser Arg Cys Val Asn Leu Pro Gly Trp Tyr His Cys Glu 
                565                 570                 575     


Cys Arg Ser Gly Phe His Asp Asp Gly Thr Tyr Ser Leu Ser Gly Glu 
            580                 585                 590         


Ser Cys Ile Asp Ile Asp Glu Cys Ala Leu Arg Thr His Thr Cys Trp 
        595                 600                 605             


Asn Asp Ser Ala Cys Ile Asn Leu Ala Gly Gly Phe Asp Cys Leu Cys 
    610                 615                 620                 


Pro Ser Gly Pro Ser Cys Ser Gly Asp Cys Pro His Glu Gly Gly Leu 
625                 630                 635                 640 


Lys His Asn Gly Gln Val Trp Ile Leu Arg Glu Asp Arg Cys Ser Val 
                645                 650                 655     


Cys Ser Cys Lys Asp Gly Lys Ile Phe Cys Arg Arg Thr Ala Cys Asp 
            660                 665                 670         


Cys Gln Asn Pro Asn Val Asp Leu Phe Cys Cys Pro Glu Cys Asp Thr 
        675                 680                 685             


Arg Val Thr Ser Gln Cys Leu Asp Gln Ser Gly Gln Lys Leu Tyr Arg 
    690                 695                 700                 


Ser Gly Asp Asn Trp Thr His Ser Cys Gln Gln Cys Arg Cys Leu Glu 
705                 710                 715                 720 


Gly Glu Ala Asp Cys Trp Pro Leu Ala Cys Pro Ser Leu Ser Cys Glu 
                725                 730                 735     


Tyr Thr Ala Ile Phe Glu Gly Glu Cys Cys Pro Arg Cys Val Ser Asp 
            740                 745                 750         


Pro Cys Leu Ala Asp Asn Ile Ala Tyr Asp Ile Arg Lys Thr Cys Leu 
        755                 760                 765             


Asp Ser Ser Gly Ile Ser Arg Leu Ser Gly Ala Val Trp Thr Met Ala 
    770                 775                 780                 


Gly Ser Pro Cys Thr Thr Cys Gln Cys Lys Asn Gly Arg Val Cys Cys 
785                 790                 795                 800 


Ser Val Asp Leu Val Cys Leu Glu Asn Asn 
                805                 810 


<210>  11
<211>  2915
<212>  DNA
<213>  Rattus norvegicus


<220>
<221>  misc_feature
<223>  NELL1

<220>
<221>  CDS
<222>  (59)..(2491)

<400>  11
aagcactggt ttcttgttag cgttggtgcg ccctgcttgg cgggggttct ccggagcg         58

atg ccg atg gat gtg att tta gtt ttg tgg ttc tgt gta tgc acc gcc        106
Met Pro Met Asp Val Ile Leu Val Leu Trp Phe Cys Val Cys Thr Ala           
1               5                   10                  15                

agg aca gtg ttg ggc ttt ggg atg gac cct gac ctt cag ctg gac atc        154
Arg Thr Val Leu Gly Phe Gly Met Asp Pro Asp Leu Gln Leu Asp Ile           
            20                  25                  30                    

atc tca gag ctc gac ctg gtg aac acc acc ctg gga gtc acg cag gtg        202
Ile Ser Glu Leu Asp Leu Val Asn Thr Thr Leu Gly Val Thr Gln Val           
        35                  40                  45                        

gct gga ctg cac aac gcc agt aaa gca ttt cta ttt caa gat gta cag        250
Ala Gly Leu His Asn Ala Ser Lys Ala Phe Leu Phe Gln Asp Val Gln           
    50                  55                  60                            

aga gag atc cat tcg gcc cct cac gtg agt gag aag ctg atc cag cta        298
Arg Glu Ile His Ser Ala Pro His Val Ser Glu Lys Leu Ile Gln Leu           
65                  70                  75                  80            

ttc cgg aat aag agc gag ttc acc ttt ttg gct aca gtg cag cag aaa        346
Phe Arg Asn Lys Ser Glu Phe Thr Phe Leu Ala Thr Val Gln Gln Lys           
                85                  90                  95                

cca tcc acc tca ggg gtg ata ctg tcc atc cgg gag ctg gag cac agc        394
Pro Ser Thr Ser Gly Val Ile Leu Ser Ile Arg Glu Leu Glu His Ser           
            100                 105                 110                   

tat ttt gaa ctg gag agc agt ggc cca aga gaa gag ata cgc tac cat        442
Tyr Phe Glu Leu Glu Ser Ser Gly Pro Arg Glu Glu Ile Arg Tyr His           
        115                 120                 125                       

tac ata cat ggt gga aag ccc agg act gag gcc ctt ccc tac cgc atg        490
Tyr Ile His Gly Gly Lys Pro Arg Thr Glu Ala Leu Pro Tyr Arg Met           
    130                 135                 140                           

gca gac gga caa tgg cac aag gtc gcg ctg tca gtg agc gcc tct cac        538
Ala Asp Gly Gln Trp His Lys Val Ala Leu Ser Val Ser Ala Ser His           
145                 150                 155                 160           

ctc ctg ctc cac atc gac tgc aat agg att tac gag cgt gtg ata gac        586
Leu Leu Leu His Ile Asp Cys Asn Arg Ile Tyr Glu Arg Val Ile Asp           
                165                 170                 175               

cct ccg gag acc aac ctt cct cca gga agc aat ctg tgg ctt ggg caa        634
Pro Pro Glu Thr Asn Leu Pro Pro Gly Ser Asn Leu Trp Leu Gly Gln           
            180                 185                 190                   

cgt aac caa aag cat ggc ttt ttc aaa gga atc atc caa gat ggt aag        682
Arg Asn Gln Lys His Gly Phe Phe Lys Gly Ile Ile Gln Asp Gly Lys           
        195                 200                 205                       

atc atc ttc atg ccg aat ggt ttc atc aca cag tgt ccc aac ctc aat        730
Ile Ile Phe Met Pro Asn Gly Phe Ile Thr Gln Cys Pro Asn Leu Asn           
    210                 215                 220                           

cgc act tgc cca aca tgc agt gac ttc ctg agc ctg gtt caa gga ata        778
Arg Thr Cys Pro Thr Cys Ser Asp Phe Leu Ser Leu Val Gln Gly Ile           
225                 230                 235                 240           

atg gat ttg caa gag ctt ttg gcc aag atg act gca aaa ctg aat tat        826
Met Asp Leu Gln Glu Leu Leu Ala Lys Met Thr Ala Lys Leu Asn Tyr           
                245                 250                 255               

gca gag acg aga ctt ggt caa ctg gaa aat tgc cac tgt gag aag acc        874
Ala Glu Thr Arg Leu Gly Gln Leu Glu Asn Cys His Cys Glu Lys Thr           
            260                 265                 270                   

tgc caa gtg agt ggg ctg ctc tac agg gac caa gac tcc tgg gtg gat        922
Cys Gln Val Ser Gly Leu Leu Tyr Arg Asp Gln Asp Ser Trp Val Asp           
        275                 280                 285                       

ggt gac aac tgt ggg aac tgc acg tgc aaa agt ggt gcc gtg gag tgc        970
Gly Asp Asn Cys Gly Asn Cys Thr Cys Lys Ser Gly Ala Val Glu Cys           
    290                 295                 300                           

cgc agg atg tcc tgt ccc ccg ctc aac tgt tcc ccg gac tca ctt cct       1018
Arg Arg Met Ser Cys Pro Pro Leu Asn Cys Ser Pro Asp Ser Leu Pro           
305                 310                 315                 320           

gtg cac att tcc ggc cag tgt tgt aaa gtt tgc aga cca aaa tgt atc       1066
Val His Ile Ser Gly Gln Cys Cys Lys Val Cys Arg Pro Lys Cys Ile           
                325                 330                 335               

tat gga gga aaa gtt ctt gct gag ggc cag cgg att tta acc aag acc       1114
Tyr Gly Gly Lys Val Leu Ala Glu Gly Gln Arg Ile Leu Thr Lys Thr           
            340                 345                 350                   

tgc cgg gaa tgt cga ggt gga gtc ttg gta aaa atc aca gaa gct tgc       1162
Cys Arg Glu Cys Arg Gly Gly Val Leu Val Lys Ile Thr Glu Ala Cys           
        355                 360                 365                       

cct cct ttg aac tgc tca gca aag gat cat att ctt cca gag aat cag       1210
Pro Pro Leu Asn Cys Ser Ala Lys Asp His Ile Leu Pro Glu Asn Gln           
    370                 375                 380                           

tgc tgc agg gtc tgc cca ggt cat aac ttc tgt gca gaa gca cct aag       1258
Cys Cys Arg Val Cys Pro Gly His Asn Phe Cys Ala Glu Ala Pro Lys           
385                 390                 395                 400           

tgc gga gaa aac tcg gaa tgc aaa aat tgg aat aca aaa gca acc tgt       1306
Cys Gly Glu Asn Ser Glu Cys Lys Asn Trp Asn Thr Lys Ala Thr Cys           
                405                 410                 415               

gag tgc aag aat gga tac atc tct gtc cag ggc aac tct gca tac tgt       1354
Glu Cys Lys Asn Gly Tyr Ile Ser Val Gln Gly Asn Ser Ala Tyr Cys           
            420                 425                 430                   

gaa gat att gat gag tgt gca gct aaa atg cac tat tgt cat gcc aac       1402
Glu Asp Ile Asp Glu Cys Ala Ala Lys Met His Tyr Cys His Ala Asn           
        435                 440                 445                       

acc gtg tgt gtc aac ttg ccg ggg ttg tat cgc tgt gac tgc gtc cca       1450
Thr Val Cys Val Asn Leu Pro Gly Leu Tyr Arg Cys Asp Cys Val Pro           
    450                 455                 460                           

ggg tac atc cgt gtg gat gac ttc tct tgt acg gag cat gat gat tgt       1498
Gly Tyr Ile Arg Val Asp Asp Phe Ser Cys Thr Glu His Asp Asp Cys           
465                 470                 475                 480           

ggc agc gga caa cac aac tgc gac aaa aat gcc atc tgt acc aac aca       1546
Gly Ser Gly Gln His Asn Cys Asp Lys Asn Ala Ile Cys Thr Asn Thr           
                485                 490                 495               

gtc cag gga cac agc tgc acc tgc cag ccg ggt tac gtg gga aat ggc       1594
Val Gln Gly His Ser Cys Thr Cys Gln Pro Gly Tyr Val Gly Asn Gly           
            500                 505                 510                   

acc atc tgc aaa gca ttc tgt gaa gag ggt tgc aga tac gga ggt acc       1642
Thr Ile Cys Lys Ala Phe Cys Glu Glu Gly Cys Arg Tyr Gly Gly Thr           
        515                 520                 525                       

tgt gtg gct cct aac aag tgt gtc tgt cct tct gga ttc acg gga agc       1690
Cys Val Ala Pro Asn Lys Cys Val Cys Pro Ser Gly Phe Thr Gly Ser           
    530                 535                 540                           

cac tgt gag aaa gat att gat gaa tgc gca gag gga ttc gtt gaa tgc       1738
His Cys Glu Lys Asp Ile Asp Glu Cys Ala Glu Gly Phe Val Glu Cys           
545                 550                 555                 560           

cac aac tac tcc cgc tgt gtt aac ctg cca ggg tgg tac cac tgt gag       1786
His Asn Tyr Ser Arg Cys Val Asn Leu Pro Gly Trp Tyr His Cys Glu           
                565                 570                 575               

tgc aga agc ggt ttc cat gac gat ggg acc tac tca ctg tcc ggg gag       1834
Cys Arg Ser Gly Phe His Asp Asp Gly Thr Tyr Ser Leu Ser Gly Glu           
            580                 585                 590                   

tcc tgc att gat atc gat gaa tgt gcc tta aga act cac act tgt tgg       1882
Ser Cys Ile Asp Ile Asp Glu Cys Ala Leu Arg Thr His Thr Cys Trp           
        595                 600                 605                       

aat gac tct gcc tgc atc aac tta gca gga gga ttt gac tgc ctg tgt       1930
Asn Asp Ser Ala Cys Ile Asn Leu Ala Gly Gly Phe Asp Cys Leu Cys           
    610                 615                 620                           

ccc tct ggg ccc tcc tgc tct ggt gac tgt ccc cac gaa gga ggg ctg       1978
Pro Ser Gly Pro Ser Cys Ser Gly Asp Cys Pro His Glu Gly Gly Leu           
625                 630                 635                 640           

aag cat aat ggg cag gtg tgg att ctg aga gaa gac agg tgt tca gtc       2026
Lys His Asn Gly Gln Val Trp Ile Leu Arg Glu Asp Arg Cys Ser Val           
                645                 650                 655               

tgt tcc tgc aag gat ggg aag ata ttc tgc cgg cgg aca gct tgt gat       2074
Cys Ser Cys Lys Asp Gly Lys Ile Phe Cys Arg Arg Thr Ala Cys Asp           
            660                 665                 670                   

tgc cag aat cca aat gtt gac ctt ttt tgc tgc cca gag tgc gat acc       2122
Cys Gln Asn Pro Asn Val Asp Leu Phe Cys Cys Pro Glu Cys Asp Thr           
        675                 680                 685                       

agg gtc acc agc caa tgt tta gat caa agt gga cag aag ctc tat cga       2170
Arg Val Thr Ser Gln Cys Leu Asp Gln Ser Gly Gln Lys Leu Tyr Arg           
    690                 695                 700                           

agt gga gac aac tgg acc cac agc tgc cag cag tgc cga tgt ctg gaa       2218
Ser Gly Asp Asn Trp Thr His Ser Cys Gln Gln Cys Arg Cys Leu Glu           
705                 710                 715                 720           

gga gag gca gac tgc tgg cct ctg gct tgc cct agt ttg ggc tgt gaa       2266
Gly Glu Ala Asp Cys Trp Pro Leu Ala Cys Pro Ser Leu Gly Cys Glu           
                725                 730                 735               

tac aca gcc atg ttt gaa ggg gag tgt tgt ccc cga tgt gtc agt gac       2314
Tyr Thr Ala Met Phe Glu Gly Glu Cys Cys Pro Arg Cys Val Ser Asp           
            740                 745                 750                   

ccc tgc ctg gct ggt aat att gcc tat gac atc aga aaa act tgc ctg       2362
Pro Cys Leu Ala Gly Asn Ile Ala Tyr Asp Ile Arg Lys Thr Cys Leu           
        755                 760                 765                       

gac agc ttt ggt gtt tcg agg ctg agc gga gcc gtg tgg aca atg gct       2410
Asp Ser Phe Gly Val Ser Arg Leu Ser Gly Ala Val Trp Thr Met Ala           
    770                 775                 780                           

gga tct cct tgt aca acc tgc aaa tgc aag aat ggg aga gtc tgc tgc       2458
Gly Ser Pro Cys Thr Thr Cys Lys Cys Lys Asn Gly Arg Val Cys Cys           
785                 790                 795                 800           

tct gtg gat ctg gag tgt att gag aat aac tga agattttaaa tggactcgtc     2511
Ser Val Asp Leu Glu Cys Ile Glu Asn Asn                                   
                805                 810                                   

acgtgagaaa atgggcaaaa tgatcatccc acctgaggaa gaagaggggc tgatttcttt     2571

ttctttttaa ccacagtcaa ttaccaaagt ctccatctga ggaaggcgtt tggattgcct     2631

ttgccacttt gctcatcctt gctgacctag tctagatgcc tgcagtaccg tgcatttcgg     2691

tcgatggttg ttgagtctca gtgttgtaaa tcgcatttcc ctcgtcagat catttacaga     2751

tacatttaaa ggggttccat gataaatgtt aatgtaactt ttgtttattt tgtgtactga     2811

cataatagag acttggcacc atttatttat ttttcttgat ttttggatca aattctaaaa     2871

ataaagttgc ctgttgcgaa aaaaaaaaaa aaaaaaaaaa aaaa                      2915


<210>  12
<211>  810
<212>  PRT
<213>  Rattus norvegicus


<220>
<221>  misc_feature
<223>  NELL1

<400>  12

Met Pro Met Asp Val Ile Leu Val Leu Trp Phe Cys Val Cys Thr Ala 
1               5                   10                  15      


Arg Thr Val Leu Gly Phe Gly Met Asp Pro Asp Leu Gln Leu Asp Ile 
            20                  25                  30          


Ile Ser Glu Leu Asp Leu Val Asn Thr Thr Leu Gly Val Thr Gln Val 
        35                  40                  45              


Ala Gly Leu His Asn Ala Ser Lys Ala Phe Leu Phe Gln Asp Val Gln 
    50                  55                  60                  


Arg Glu Ile His Ser Ala Pro His Val Ser Glu Lys Leu Ile Gln Leu 
65                  70                  75                  80  


Phe Arg Asn Lys Ser Glu Phe Thr Phe Leu Ala Thr Val Gln Gln Lys 
                85                  90                  95      


Pro Ser Thr Ser Gly Val Ile Leu Ser Ile Arg Glu Leu Glu His Ser 
            100                 105                 110         


Tyr Phe Glu Leu Glu Ser Ser Gly Pro Arg Glu Glu Ile Arg Tyr His 
        115                 120                 125             


Tyr Ile His Gly Gly Lys Pro Arg Thr Glu Ala Leu Pro Tyr Arg Met 
    130                 135                 140                 


Ala Asp Gly Gln Trp His Lys Val Ala Leu Ser Val Ser Ala Ser His 
145                 150                 155                 160 


Leu Leu Leu His Ile Asp Cys Asn Arg Ile Tyr Glu Arg Val Ile Asp 
                165                 170                 175     


Pro Pro Glu Thr Asn Leu Pro Pro Gly Ser Asn Leu Trp Leu Gly Gln 
            180                 185                 190         


Arg Asn Gln Lys His Gly Phe Phe Lys Gly Ile Ile Gln Asp Gly Lys 
        195                 200                 205             


Ile Ile Phe Met Pro Asn Gly Phe Ile Thr Gln Cys Pro Asn Leu Asn 
    210                 215                 220                 


Arg Thr Cys Pro Thr Cys Ser Asp Phe Leu Ser Leu Val Gln Gly Ile 
225                 230                 235                 240 


Met Asp Leu Gln Glu Leu Leu Ala Lys Met Thr Ala Lys Leu Asn Tyr 
                245                 250                 255     


Ala Glu Thr Arg Leu Gly Gln Leu Glu Asn Cys His Cys Glu Lys Thr 
            260                 265                 270         


Cys Gln Val Ser Gly Leu Leu Tyr Arg Asp Gln Asp Ser Trp Val Asp 
        275                 280                 285             


Gly Asp Asn Cys Gly Asn Cys Thr Cys Lys Ser Gly Ala Val Glu Cys 
    290                 295                 300                 


Arg Arg Met Ser Cys Pro Pro Leu Asn Cys Ser Pro Asp Ser Leu Pro 
305                 310                 315                 320 


Val His Ile Ser Gly Gln Cys Cys Lys Val Cys Arg Pro Lys Cys Ile 
                325                 330                 335     


Tyr Gly Gly Lys Val Leu Ala Glu Gly Gln Arg Ile Leu Thr Lys Thr 
            340                 345                 350         


Cys Arg Glu Cys Arg Gly Gly Val Leu Val Lys Ile Thr Glu Ala Cys 
        355                 360                 365             


Pro Pro Leu Asn Cys Ser Ala Lys Asp His Ile Leu Pro Glu Asn Gln 
    370                 375                 380                 


Cys Cys Arg Val Cys Pro Gly His Asn Phe Cys Ala Glu Ala Pro Lys 
385                 390                 395                 400 


Cys Gly Glu Asn Ser Glu Cys Lys Asn Trp Asn Thr Lys Ala Thr Cys 
                405                 410                 415     


Glu Cys Lys Asn Gly Tyr Ile Ser Val Gln Gly Asn Ser Ala Tyr Cys 
            420                 425                 430         


Glu Asp Ile Asp Glu Cys Ala Ala Lys Met His Tyr Cys His Ala Asn 
        435                 440                 445             


Thr Val Cys Val Asn Leu Pro Gly Leu Tyr Arg Cys Asp Cys Val Pro 
    450                 455                 460                 


Gly Tyr Ile Arg Val Asp Asp Phe Ser Cys Thr Glu His Asp Asp Cys 
465                 470                 475                 480 


Gly Ser Gly Gln His Asn Cys Asp Lys Asn Ala Ile Cys Thr Asn Thr 
                485                 490                 495     


Val Gln Gly His Ser Cys Thr Cys Gln Pro Gly Tyr Val Gly Asn Gly 
            500                 505                 510         


Thr Ile Cys Lys Ala Phe Cys Glu Glu Gly Cys Arg Tyr Gly Gly Thr 
        515                 520                 525             


Cys Val Ala Pro Asn Lys Cys Val Cys Pro Ser Gly Phe Thr Gly Ser 
    530                 535                 540                 


His Cys Glu Lys Asp Ile Asp Glu Cys Ala Glu Gly Phe Val Glu Cys 
545                 550                 555                 560 


His Asn Tyr Ser Arg Cys Val Asn Leu Pro Gly Trp Tyr His Cys Glu 
                565                 570                 575     


Cys Arg Ser Gly Phe His Asp Asp Gly Thr Tyr Ser Leu Ser Gly Glu 
            580                 585                 590         


Ser Cys Ile Asp Ile Asp Glu Cys Ala Leu Arg Thr His Thr Cys Trp 
        595                 600                 605             


Asn Asp Ser Ala Cys Ile Asn Leu Ala Gly Gly Phe Asp Cys Leu Cys 
    610                 615                 620                 


Pro Ser Gly Pro Ser Cys Ser Gly Asp Cys Pro His Glu Gly Gly Leu 
625                 630                 635                 640 


Lys His Asn Gly Gln Val Trp Ile Leu Arg Glu Asp Arg Cys Ser Val 
                645                 650                 655     


Cys Ser Cys Lys Asp Gly Lys Ile Phe Cys Arg Arg Thr Ala Cys Asp 
            660                 665                 670         


Cys Gln Asn Pro Asn Val Asp Leu Phe Cys Cys Pro Glu Cys Asp Thr 
        675                 680                 685             


Arg Val Thr Ser Gln Cys Leu Asp Gln Ser Gly Gln Lys Leu Tyr Arg 
    690                 695                 700                 


Ser Gly Asp Asn Trp Thr His Ser Cys Gln Gln Cys Arg Cys Leu Glu 
705                 710                 715                 720 


Gly Glu Ala Asp Cys Trp Pro Leu Ala Cys Pro Ser Leu Gly Cys Glu 
                725                 730                 735     


Tyr Thr Ala Met Phe Glu Gly Glu Cys Cys Pro Arg Cys Val Ser Asp 
            740                 745                 750         


Pro Cys Leu Ala Gly Asn Ile Ala Tyr Asp Ile Arg Lys Thr Cys Leu 
        755                 760                 765             


Asp Ser Phe Gly Val Ser Arg Leu Ser Gly Ala Val Trp Thr Met Ala 
    770                 775                 780                 


Gly Ser Pro Cys Thr Thr Cys Lys Cys Lys Asn Gly Arg Val Cys Cys 
785                 790                 795                 800 


Ser Val Asp Leu Glu Cys Ile Glu Asn Asn 
                805                 810 


<210>  13
<211>  810
<212>  PRT
<213>  Felis catus


<220>
<221>  MISC_FEATURE
<223>  NELL1 isoform 1

<400>  13

Met Pro Arg Asp Val Ile Leu Val Val Trp Phe Cys Val Cys Thr Ala 
1               5                   10                  15      


Arg Thr Val Val Gly Phe Gly Thr Asp Pro Asp Leu Gln Val Asp Ile 
            20                  25                  30          


Ile Ala Glu Leu Asp Leu Val Asn Thr Thr Ala Gly Val Thr Gln Val 
        35                  40                  45              


Ser Gly Leu His Asn Ala Ser Lys Ala Tyr Leu Phe Gln Glu Thr Glu 
    50                  55                  60                  


Arg Glu Ile His Ala Ala Pro His Val Ser Glu Lys Leu Ile Gln Leu 
65                  70                  75                  80  


Phe Arg Asn Lys Ser Glu Phe Ser Phe Leu Ala Thr Val Gln Gln Lys 
                85                  90                  95      


Pro Ser Thr Ser Gly Val Ile Leu Ser Ile Arg Glu Leu Glu His Ser 
            100                 105                 110         


Tyr Phe Glu Leu Glu Ser Ser Gly Leu Arg Asp Glu Ile Arg Tyr His 
        115                 120                 125             


Tyr Ile His Asn Gly Lys Pro Arg Thr Glu Ala Leu Pro Tyr Arg Met 
    130                 135                 140                 


Ala Asp Gly Gln Trp His Lys Val Ala Leu Ser Ile Ser Ala Ser His 
145                 150                 155                 160 


Leu Leu Leu His Val Asp Cys Asn Arg Ile Tyr Glu Arg Val Ile Asp 
                165                 170                 175     


Pro Pro Glu Thr Asn Leu Pro Pro Gly Ser Asn Val Trp Leu Gly Gln 
            180                 185                 190         


Arg Asn Gln Lys His Gly Leu Phe Lys Gly Ile Ile Gln Asp Gly Lys 
        195                 200                 205             


Ile Ile Phe Met Pro Asn Gly Tyr Ile Thr Gln Cys Pro Asn Leu Asn 
    210                 215                 220                 


Arg Thr Cys Pro Thr Cys Ser Asp Phe Leu Ser Leu Val Gln Gly Ile 
225                 230                 235                 240 


Met Asp Leu Gln Glu Leu Leu Ala Lys Met Thr Ala Lys Leu Asn Tyr 
                245                 250                 255     


Ala Glu Thr Arg Leu Asn Gln Leu Glu Asn Cys His Cys Glu Lys Thr 
            260                 265                 270         


Cys Gln Val Ser Gly Leu Leu Tyr Arg Asp Gln Asp Ser Trp Val Asp 
        275                 280                 285             


Gly Asp His Cys Arg Asn Cys Thr Cys Lys Ser Gly Ala Val Glu Cys 
    290                 295                 300                 


Arg Arg Met Ser Cys Pro Pro Leu Asn Cys Ser Pro Asp Ser Leu Pro 
305                 310                 315                 320 


Val His Ile Ala Gly Gln Cys Cys Lys Val Cys Arg Pro Lys Cys Ile 
                325                 330                 335     


Tyr Gly Gly Lys Val Leu Ala Glu Gly Gln Arg Ile Leu Thr Lys Ser 
            340                 345                 350         


Cys Arg Glu Cys Arg Gly Gly Val Leu Val Lys Ile Thr Asp Ala Cys 
        355                 360                 365             


Pro Pro Leu Asn Cys Ser Glu Lys Asp His Ile Leu Pro Glu Asn Gln 
    370                 375                 380                 


Cys Cys Ser Val Cys Arg Gly His Asn Phe Cys Ala Glu Gly Pro Thr 
385                 390                 395                 400 


Cys Gly Glu Asn Ser Glu Cys Lys Asn Trp Asn Thr Lys Ala Thr Cys 
                405                 410                 415     


Glu Cys Lys Asn Gly Tyr Ile Ser Val Gln Gly Asp Ser Ala Tyr Cys 
            420                 425                 430         


Glu Asp Ile Asp Glu Cys Ala Ala Lys Met His Tyr Cys His Ala Asn 
        435                 440                 445             


Thr Val Cys Val Asn Leu Pro Gly Leu Tyr Arg Cys Asp Cys Val Pro 
    450                 455                 460                 


Gly Tyr Ile Arg Val Asp Asp Phe Ser Cys Thr Glu His Asp Glu Cys 
465                 470                 475                 480 


Gly Ser Gly Gln His Asn Cys Asp Glu Asn Ala Ile Cys Thr Asn Thr 
                485                 490                 495     


Val Gln Gly His Ser Cys Thr Cys Lys Pro Gly Tyr Val Gly Asn Gly 
            500                 505                 510         


Thr Ile Cys Arg Ala Phe Cys Gln Glu Gly Cys Arg Tyr Gly Gly Thr 
        515                 520                 525             


Cys Val Ser Pro Asn Lys Cys Val Cys Pro Ser Gly Phe Thr Gly Ser 
    530                 535                 540                 


His Cys Glu Lys Asp Ile Asp Glu Cys Thr Glu Gly Ile Ile Glu Cys 
545                 550                 555                 560 


His Asn His Ser Arg Cys Val Asn Leu Pro Gly Trp Tyr His Cys Glu 
                565                 570                 575     


Cys Arg Ser Gly Phe His Asp Asp Gly Thr Tyr Ser Leu Ser Gly Glu 
            580                 585                 590         


Ser Cys Ile Asp Ile Asp Glu Cys Ala Leu Arg Thr His Thr Cys Trp 
        595                 600                 605             


Asn Asp Ser Ala Cys Ile Asn Leu Ala Gly Gly Phe Asp Cys Leu Cys 
    610                 615                 620                 


Pro Ser Gly Pro Ser Cys Ser Gly Asp Cys Pro His Glu Gly Gly Leu 
625                 630                 635                 640 


Lys Arg Asn Gly Gln Val Trp Thr Leu Lys Glu Asp Arg Cys Ser Val 
                645                 650                 655     


Cys Ser Cys Lys Asp Gly Lys Ile Phe Cys Arg Arg Thr Ala Cys Asp 
            660                 665                 670         


Cys Gln Asn Pro Ser Val Asp Leu Phe Cys Cys Pro Glu Cys Asp Thr 
        675                 680                 685             


Arg Val Thr Ser Gln Cys Leu Asp Gln Asn Gly His Lys Leu Tyr Arg 
    690                 695                 700                 


Ser Gly Asp Asn Trp Thr His Ser Cys Gln Gln Cys Arg Cys Leu Glu 
705                 710                 715                 720 


Gly Glu Val Asp Cys Trp Pro Leu Thr Cys Pro Asn Leu Ser Cys Glu 
                725                 730                 735     


Tyr Thr Ala Met Leu Glu Gly Glu Cys Cys Pro Arg Cys Val Ser Asp 
            740                 745                 750         


Pro Cys Leu Ala Asp Asn Ile Ala Tyr Asp Ile Arg Lys Thr Cys Leu 
        755                 760                 765             


Asp Ser Tyr Gly Ile Ser Arg Leu Ser Gly Ala Val Trp Thr Met Ala 
    770                 775                 780                 


Gly Ser Pro Cys Thr Thr Cys Lys Cys Lys Asn Gly Ser Val Cys Cys 
785                 790                 795                 800 


Ser Val Asp Leu Glu Cys Leu His Asn Asn 
                805                 810 


<210>  14
<211>  763
<212>  PRT
<213>  Felis catus


<220>
<221>  MISC_FEATURE
<223>  NELL1 isoform 2

<400>  14

Met Pro Arg Asp Val Ile Leu Val Val Trp Phe Cys Val Cys Thr Ala 
1               5                   10                  15      


Arg Thr Val Val Gly Phe Gly Thr Asp Pro Asp Leu Gln Val Asp Ile 
            20                  25                  30          


Ile Ala Glu Leu Asp Leu Val Asn Thr Thr Ala Gly Val Thr Gln Val 
        35                  40                  45              


Ser Gly Leu His Asn Ala Ser Lys Ala Tyr Leu Phe Gln Glu Thr Glu 
    50                  55                  60                  


Arg Glu Ile His Ala Ala Pro His Val Ser Glu Lys Leu Ile Gln Leu 
65                  70                  75                  80  


Phe Arg Asn Lys Ser Glu Phe Ser Phe Leu Ala Thr Val Gln Gln Lys 
                85                  90                  95      


Pro Ser Thr Ser Gly Val Ile Leu Ser Ile Arg Glu Leu Glu His Ser 
            100                 105                 110         


Tyr Phe Glu Leu Glu Ser Ser Gly Leu Arg Asp Glu Ile Arg Tyr His 
        115                 120                 125             


Tyr Ile His Asn Gly Lys Pro Arg Thr Glu Ala Leu Pro Tyr Arg Met 
    130                 135                 140                 


Ala Asp Gly Gln Trp His Lys Val Ala Leu Ser Ile Ser Ala Ser His 
145                 150                 155                 160 


Leu Leu Leu His Val Asp Cys Asn Arg Ile Tyr Glu Arg Val Ile Asp 
                165                 170                 175     


Pro Pro Glu Thr Asn Leu Pro Pro Gly Ser Asn Val Trp Leu Gly Gln 
            180                 185                 190         


Arg Asn Gln Lys His Gly Leu Phe Lys Gly Ile Ile Gln Asp Gly Lys 
        195                 200                 205             


Ile Ile Phe Met Pro Asn Gly Tyr Ile Thr Gln Cys Pro Asn Leu Asn 
    210                 215                 220                 


Arg Thr Cys Pro Thr Cys Ser Asp Phe Leu Ser Leu Val Gln Gly Ile 
225                 230                 235                 240 


Met Asp Leu Gln Glu Leu Leu Ala Lys Met Thr Ala Lys Leu Asn Tyr 
                245                 250                 255     


Ala Glu Thr Arg Leu Asn Gln Leu Glu Asn Cys His Cys Glu Lys Thr 
            260                 265                 270         


Cys Gln Val Ser Gly Leu Leu Tyr Arg Asp Gln Asp Ser Trp Val Asp 
        275                 280                 285             


Gly Asp His Cys Arg Asn Cys Thr Cys Lys Ser Gly Ala Val Glu Cys 
    290                 295                 300                 


Arg Arg Met Ser Cys Pro Pro Leu Asn Cys Ser Pro Asp Ser Leu Pro 
305                 310                 315                 320 


Val His Ile Ala Gly Gln Cys Cys Lys Val Cys Arg Pro Lys Cys Ile 
                325                 330                 335     


Tyr Gly Gly Lys Val Leu Ala Glu Gly Gln Arg Ile Leu Thr Lys Ser 
            340                 345                 350         


Cys Arg Glu Cys Arg Gly Gly Val Leu Val Lys Ile Thr Asp Ala Cys 
        355                 360                 365             


Pro Pro Leu Asn Cys Ser Glu Lys Asp His Ile Leu Pro Glu Asn Gln 
    370                 375                 380                 


Cys Cys Ser Val Cys Arg Gly His Asn Phe Cys Ala Glu Gly Pro Thr 
385                 390                 395                 400 


Cys Gly Glu Asn Ser Glu Cys Lys Asn Trp Asn Thr Lys Ala Thr Cys 
                405                 410                 415     


Glu Cys Lys Asn Gly Tyr Ile Ser Val Gln Gly Asp Ser Ala Tyr Cys 
            420                 425                 430         


Glu Asp Ile Asp Glu Cys Ala Ala Lys Met His Tyr Cys His Ala Asn 
        435                 440                 445             


Thr Val Cys Val Asn Leu Pro Gly Leu Tyr Arg Cys Asp Cys Val Pro 
    450                 455                 460                 


Gly Tyr Ile Arg Val Asp Asp Phe Ser Cys Thr Glu His Asp Glu Cys 
465                 470                 475                 480 


Gly Ser Gly Gln His Asn Cys Asp Glu Asn Ala Ile Cys Thr Asn Thr 
                485                 490                 495     


Val Gln Gly His Ser Cys Thr Cys Lys Pro Gly Tyr Val Gly Asn Gly 
            500                 505                 510         


Thr Ile Cys Arg Ala Phe Cys Gln Glu Gly Cys Arg Tyr Gly Gly Thr 
        515                 520                 525             


Cys Val Ser Pro Asn Lys Cys Val Cys Pro Ser Gly Phe Thr Gly Ser 
    530                 535                 540                 


His Cys Glu Lys Asp Ile Asp Glu Cys Ala Leu Arg Thr His Thr Cys 
545                 550                 555                 560 


Trp Asn Asp Ser Ala Cys Ile Asn Leu Ala Gly Gly Phe Asp Cys Leu 
                565                 570                 575     


Cys Pro Ser Gly Pro Ser Cys Ser Gly Asp Cys Pro His Glu Gly Gly 
            580                 585                 590         


Leu Lys Arg Asn Gly Gln Val Trp Thr Leu Lys Glu Asp Arg Cys Ser 
        595                 600                 605             


Val Cys Ser Cys Lys Asp Gly Lys Ile Phe Cys Arg Arg Thr Ala Cys 
    610                 615                 620                 


Asp Cys Gln Asn Pro Ser Val Asp Leu Phe Cys Cys Pro Glu Cys Asp 
625                 630                 635                 640 


Thr Arg Val Thr Ser Gln Cys Leu Asp Gln Asn Gly His Lys Leu Tyr 
                645                 650                 655     


Arg Ser Gly Asp Asn Trp Thr His Ser Cys Gln Gln Cys Arg Cys Leu 
            660                 665                 670         


Glu Gly Glu Val Asp Cys Trp Pro Leu Thr Cys Pro Asn Leu Ser Cys 
        675                 680                 685             


Glu Tyr Thr Ala Met Leu Glu Gly Glu Cys Cys Pro Arg Cys Val Ser 
    690                 695                 700                 


Asp Pro Cys Leu Ala Asp Asn Ile Ala Tyr Asp Ile Arg Lys Thr Cys 
705                 710                 715                 720 


Leu Asp Ser Tyr Gly Ile Ser Arg Leu Ser Gly Ala Val Trp Thr Met 
                725                 730                 735     


Ala Gly Ser Pro Cys Thr Thr Cys Lys Cys Lys Asn Gly Ser Val Cys 
            740                 745                 750         


Cys Ser Val Asp Leu Glu Cys Leu His Asn Asn 
        755                 760             


<210>  15
<211>  901
<212>  PRT
<213>  Canis lupis familiaris


<220>
<221>  MISC_FEATURE
<223>  NELL1

<400>  15

Met Thr Ser Thr Ser Phe Leu Leu Trp Leu Gly Cys Val His Asn Thr 
1               5                   10                  15      


Lys Phe Pro Phe Pro Leu Val Leu Val Thr Arg Ala Ile Val Val Val 
            20                  25                  30          


Val Val Glu Val Val Gly Val Gly Ser Pro Gly Val Arg Ile Arg Ser 
        35                  40                  45              


Thr Gly Cys Asp Ile Leu Leu Leu Tyr Glu Val Leu Glu His Leu Leu 
    50                  55                  60                  


Gly Ile Arg Phe Leu Cys Val Asp Gln Gly Glu Asn Ser Cys His His 
65                  70                  75                  80  


Gly Gln Cys Ala Cys Arg Leu Gln Val Ile Val Pro Lys Ala Leu Met 
                85                  90                  95      


Ser Val Phe Glu Ala Lys Thr Ala Val Cys Phe Phe Pro Val Val Gly 
            100                 105                 110         


Phe Gly Thr Asp Pro Asp Leu Gln Met Asp Ile Ile Thr Glu Leu Asp 
        115                 120                 125             


Leu Val Asn Ile Ser Leu Gly Val Thr Gln Val Ser Gly Leu His Asn 
    130                 135                 140                 


Ala Ser Lys Ala Tyr Val Phe Gln Asp Thr Ala Arg Glu Ile His Ala 
145                 150                 155                 160 


Ala Pro His Val Ser Glu Lys Leu Ile Gln Leu Phe Arg Asn Lys Ser 
                165                 170                 175     


Asp Phe Thr Phe Leu Ala Thr Val Gln Gln Lys Pro Ser Thr Ser Gly 
            180                 185                 190         


Val Ile Leu Ser Ile Arg Glu Leu Glu His Ser Tyr Phe Glu Leu Glu 
        195                 200                 205             


Ser Ser Gly Leu Arg Asp Glu Ile Arg Tyr His Tyr Met His Asn Gly 
    210                 215                 220                 


Lys Pro Arg Thr Glu Ala Leu Pro Tyr Arg Leu Ala Asp Gly Gln Trp 
225                 230                 235                 240 


His Lys Val Ala Leu Ser Val Ser Ala Ser His Leu Leu Leu His Ile 
                245                 250                 255     


Asp Cys Asn Arg Ile Tyr Glu Arg Val Ile Asp Pro Pro Glu Thr Asn 
            260                 265                 270         


Leu Pro Pro Gly Ser Asn Leu Trp Leu Gly Gln Arg Asn Gln Lys His 
        275                 280                 285             


Gly Phe Phe Lys Gly Ile Ile Gln Asp Gly Lys Ile Ile Phe Met Pro 
    290                 295                 300                 


Asn Gly Tyr Ile Thr Gln Cys Pro Asn Leu Asn Arg Thr Cys Pro Thr 
305                 310                 315                 320 


Cys Ser Asp Phe Leu Ser Leu Val Gln Gly Ile Met Asp Leu Gln Glu 
                325                 330                 335     


Leu Leu Ala Lys Met Thr Ala Lys Leu Asn Tyr Ala Glu Thr Arg Leu 
            340                 345                 350         


Ser Gln Leu Glu Asn Cys His Cys Glu Lys Thr Cys Gln Val Ser Gly 
        355                 360                 365             


Leu Leu Tyr Arg Asp Gln Asp Ser Trp Val Asp Gly Asp His Cys Arg 
    370                 375                 380                 


Asn Cys Thr Cys Lys Gly Gly Ala Val Glu Cys Arg Arg Met Ser Cys 
385                 390                 395                 400 


Pro Pro Leu Asn Cys Ser Pro Asp Ser Leu Pro Val His Ile Ala Gly 
                405                 410                 415     


Gln Cys Cys Lys Val Cys Arg Pro Lys Cys Ile Tyr Gly Gly Arg Val 
            420                 425                 430         


Leu Ala Glu Gly Gln Arg Ile Leu Thr Lys Ser Cys Arg Glu Cys Arg 
        435                 440                 445             


Gly Gly Val Leu Val Lys Ile Thr Asp Ala Cys Pro Pro Leu Asn Cys 
    450                 455                 460                 


Ser Glu Lys Asp His Ile Leu Pro Glu Asn Gln Cys Cys Ser Val Cys 
465                 470                 475                 480 


Arg Gly His Asn Phe Cys Ala Glu Gly Pro Lys Cys Gly Glu Asn Ser 
                485                 490                 495     


Glu Cys Lys Asn Trp Asn Thr Lys Ala Thr Cys Glu Cys Lys Asn Gly 
            500                 505                 510         


Tyr Ile Ser Val Gln Gly Asp Ser Ala Tyr Cys Glu Asp Ile Asp Glu 
        515                 520                 525             


Cys Ala Ala Lys Met His Tyr Cys His Ala Asn Thr Val Cys Val Asn 
    530                 535                 540                 


Leu Pro Gly Leu Tyr Arg Cys Asp Cys Val Pro Gly Tyr Ile Arg Val 
545                 550                 555                 560 


Asp Asp Phe Ser Cys Thr Glu His Asp Glu Cys Gly Ser Gly Gln His 
                565                 570                 575     


Asn Cys Asp Glu Asn Ala Ile Cys Thr Asn Thr Val Arg Gly His Ser 
            580                 585                 590         


Cys Thr Cys Lys Pro Gly Tyr Val Gly Asn Gly Thr Ile Cys Arg Ala 
        595                 600                 605             


Phe Cys Gln Glu Gly Cys Arg Tyr Gly Gly Ser Cys Val Ser Pro Asn 
    610                 615                 620                 


Lys Cys Val Cys Pro Ser Gly Phe Thr Gly Ser His Cys Glu Lys Asp 
625                 630                 635                 640 


Ile Asp Glu Cys Thr Glu Gly Ile Ile Glu Cys His Asn His Ser Arg 
                645                 650                 655     


Cys Val Asn Leu Pro Gly Trp Tyr His Cys Glu Cys Arg Ser Gly Phe 
            660                 665                 670         


His Asp Asp Gly Thr Tyr Ser Leu Ser Gly Glu Ser Cys Ile Asp Ile 
        675                 680                 685             


Asp Glu Cys Ala Leu Arg Thr His Thr Cys Trp Asn Asp Ser Ala Cys 
    690                 695                 700                 


Ile Asn Leu Ala Gly Gly Phe Asp Cys Leu Cys Pro Ser Gly Pro Ser 
705                 710                 715                 720 


Cys Ser Gly Asp Cys Pro His Glu Gly Gly Leu Lys Arg Asn Gly Gln 
                725                 730                 735     


Val Trp Thr Leu Lys Glu Asp Arg Cys Ser Val Cys Ser Cys Lys Asp 
            740                 745                 750         


Gly Lys Ile Leu Cys Arg Arg Thr Ala Cys Asp Cys Gln Asn Pro Ser 
        755                 760                 765             


Val Asp Leu Phe Cys Cys Pro Glu Cys Asp Thr Arg Val Thr Ser Gln 
    770                 775                 780                 


Cys Leu Asp Gln Asn Gly His Lys Leu Tyr Arg Ser Gly Asp Asn Trp 
785                 790                 795                 800 


Thr His Ser Cys Gln Gln Cys Arg Cys Leu Glu Gly Glu Val Asp Cys 
                805                 810                 815     


Trp Pro Leu Thr Cys Pro Asn Leu Ser Cys Glu Tyr Thr Ala Ile Leu 
            820                 825                 830         


Glu Gly Glu Cys Cys Pro Arg Cys Val Ser Asp Pro Cys Leu Ala Asp 
        835                 840                 845             


Asn Ile Ala Tyr Asp Ile Arg Lys Thr Cys Leu Asp Ser Tyr Gly Ile 
    850                 855                 860                 


Ser Arg Leu Ser Gly Ser Val Trp Thr Met Ala Gly Ser Pro Cys Thr 
865                 870                 875                 880 


Thr Cys Lys Cys Lys Asn Gly Ser Val Cys Cys Ser Val Asp Leu Glu 
                885                 890                 895     


Cys Leu His Asn Asn 
            900     


<210>  16
<211>  810
<212>  PRT
<213>  Ovis aries


<220>
<221>  MISC_FEATURE
<223>  NELL1

<400>  16

Met Pro Arg Gly Val Ile Leu Val Val Cys Phe Cys Val Cys Ala Ala 
1               5                   10                  15      


Arg Thr Val Val Gly Phe Gly Met Asp Pro Asp Leu Gln Leu Asp Ile 
            20                  25                  30          


Ile Thr Glu Leu Asp Leu Val Asn Thr Thr Leu Gly Val Thr Gln Val 
        35                  40                  45              


Ser Gly Leu His Asn Thr Ser Lys Ala Phe Leu Phe Gln Asp Ala Glu 
    50                  55                  60                  


Arg Glu Ile His Ala Ala Pro His Val Ser Glu Lys Leu Ile Gln Leu 
65                  70                  75                  80  


Phe Arg Asn Lys Ser Glu Phe Thr Phe Leu Ala Thr Val Gln Gln Lys 
                85                  90                  95      


Pro Ser Thr Ser Gly Val Ile Leu Ser Ile Arg Glu Leu Glu His Ser 
            100                 105                 110         


Tyr Phe Glu Leu Glu Ser Ser Gly Leu Arg Asp Glu Ile Arg Tyr His 
        115                 120                 125             


Tyr Met His Ser Gly Arg Pro Arg Thr Glu Ala Leu Pro Tyr Arg Leu 
    130                 135                 140                 


Ala Asp Gly Gln Trp His Arg Val Ala Leu Ser Val Ser Ala Ser His 
145                 150                 155                 160 


Leu Leu Leu His Ile Asp Cys Asn Arg Ile Tyr Glu Arg Val Ile Asp 
                165                 170                 175     


Pro Pro Glu Thr Asn Leu Pro Pro Gly Ser Asn Leu Trp Leu Gly Gln 
            180                 185                 190         


Arg Asn Gln Lys His Gly Leu Phe Lys Gly Ile Ile Gln Asp Gly Lys 
        195                 200                 205             


Ile Ile Phe Met Pro Asn Gly Tyr Ile Thr Gln Cys Pro Asn Leu Asn 
    210                 215                 220                 


Arg Thr Cys Pro Thr Cys Ser Asp Phe Leu Ser Leu Val Gln Gly Ile 
225                 230                 235                 240 


Met Asp Leu Gln Glu Leu Leu Ala Lys Met Thr Ala Lys Leu Asn Tyr 
                245                 250                 255     


Ala Glu Thr Arg Leu Ser Gln Leu Glu Asn Cys His Cys Glu Lys Thr 
            260                 265                 270         


Cys Gln Val Ser Gly Leu Leu Tyr Arg Asp Gln Asp Ser Trp Val Asp 
        275                 280                 285             


Gly Asp His Cys Arg Asn Cys Thr Cys Lys Ser Gly Ala Val Glu Cys 
    290                 295                 300                 


Arg Arg Met Ser Cys Pro Pro Leu Asn Cys Ser Pro Asp Ser Leu Pro 
305                 310                 315                 320 


Val His Ile Ala Gly Gln Cys Cys Lys Val Cys Arg Pro Lys Cys Ile 
                325                 330                 335     


Tyr Gly Gly Lys Val Leu Ala Glu Gly Gln Arg Ile Leu Ser Lys Asn 
            340                 345                 350         


Cys Gln Glu Cys Arg Gly Gly Val Leu Val Lys Ile Thr Glu Ala Cys 
        355                 360                 365             


Pro Leu Leu Asn Cys Ser Glu Lys Asp His Ile Leu Pro Glu Asn Gln 
    370                 375                 380                 


Cys Cys Ser Val Cys Arg Gly His Asn Phe Cys Ala Glu Gly Pro Lys 
385                 390                 395                 400 


Cys Gly Glu Asn Ser Glu Cys Lys Asn Trp Asn Thr Lys Ala Thr Cys 
                405                 410                 415     


Glu Cys Lys Asn Gly Tyr Ile Ser Val Gln Gly Asp Ser Ala Tyr Cys 
            420                 425                 430         


Glu Asp Ile Asp Glu Cys Ala Ala Lys Met His Tyr Cys His Ala Asn 
        435                 440                 445             


Thr Val Cys Val Asn Leu Pro Gly Leu Tyr Arg Cys Asp Cys Val Pro 
    450                 455                 460                 


Gly Tyr Ile Arg Val Asp Asp Phe Ser Cys Thr Glu His Asp Asp Cys 
465                 470                 475                 480 


Gly Ser Gly Gln His Asn Cys Asp Glu Asn Ala Ile Cys Thr Asn Thr 
                485                 490                 495     


Val Gln Gly His Ser Cys Thr Cys Lys Pro Gly Tyr Val Gly Asn Gly 
            500                 505                 510         


Thr Ile Cys Arg Ala Phe Cys Glu Glu Gly Cys Arg Tyr Gly Gly Thr 
        515                 520                 525             


Cys Met Ala Pro Asn Lys Cys Val Cys Pro Ser Gly Phe Thr Gly Ser 
    530                 535                 540                 


His Cys Glu Lys Asp Ile Asp Glu Cys Ala Glu Gly Ile Ile Glu Cys 
545                 550                 555                 560 


His Ser His Ser Arg Cys Val Asn Leu Pro Gly Trp Tyr His Cys Glu 
                565                 570                 575     


Cys Arg Ser Gly Phe His Asp Asp Gly Thr Tyr Ser Leu Ser Gly Glu 
            580                 585                 590         


Ser Cys Val Asp Ile Asp Glu Cys Ala Leu Arg Thr His Thr Cys Trp 
        595                 600                 605             


Asn Asp Ser Ala Cys Ile Asn Leu Ala Gly Gly Phe Asp Cys Leu Cys 
    610                 615                 620                 


Pro Ser Gly Pro Ser Cys Ser Gly Asp Cys Pro His Glu Gly Gly Leu 
625                 630                 635                 640 


Lys Arg Asn Gly Gln Val Trp Thr Leu Lys Glu Asp Arg Cys Ser Val 
                645                 650                 655     


Cys Ser Cys Lys Asp Gly Lys Ile Phe Cys Arg Arg Thr Ala Cys Asp 
            660                 665                 670         


Cys Gln Asn Pro Ser Val Asp Leu Phe Cys Cys Pro Glu Cys Asp Thr 
        675                 680                 685             


Arg Val Thr Ser Gln Cys Leu Asp Gln Asn Gly Asn Lys Leu Tyr Arg 
    690                 695                 700                 


Ser Gly Asp Asn Trp Thr His Ser Cys Gln Gln Cys Arg Cys Leu Glu 
705                 710                 715                 720 


Gly Glu Val Asp Cys Trp Pro Leu Thr Cys Pro Ser Leu Ser Cys Glu 
                725                 730                 735     


Tyr Thr Thr Ile Leu Glu Gly Glu Cys Cys Pro Arg Cys Val Ser Asp 
            740                 745                 750         


Pro Cys Leu Ala Asp Asn Ile Ala Tyr Asp Ile Arg Lys Thr Cys Leu 
        755                 760                 765             


Asp Ser Tyr Gly Leu Ser Arg Leu Ser Gly Ser Val Trp Thr Met Ala 
    770                 775                 780                 


Gly Ser Pro Cys Thr Thr Cys Lys Cys Lys Asn Gly Ser Val Cys Cys 
785                 790                 795                 800 


Ser Val Asp Leu Glu Cys Leu His Asn Asn 
                805                 810 


<210>  17
<211>  610
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  NELL1 fragment

<400>  17

Phe Gly Met Asp Pro Asp Leu Gln Met Asp Ile Val Thr Glu Leu Asp 
1               5                   10                  15      


Leu Val Asn Thr Thr Leu Gly Val Ala Gln Val Ser Gly Met His Asn 
            20                  25                  30          


Ala Ser Lys Ala Phe Leu Phe Gln Asp Ile Glu Arg Glu Ile His Ala 
        35                  40                  45              


Ala Pro His Val Ser Glu Lys Leu Ile Gln Leu Phe Arg Asn Lys Ser 
    50                  55                  60                  


Glu Phe Thr Ile Leu Ala Thr Val Gln Gln Lys Pro Ser Thr Ser Gly 
65                  70                  75                  80  


Val Ile Leu Ser Ile Arg Glu Leu Glu His Ser Tyr Phe Glu Leu Glu 
                85                  90                  95      


Ser Ser Gly Leu Arg Asp Glu Ile Arg Tyr His Tyr Ile His Asn Gly 
            100                 105                 110         


Lys Pro Arg Thr Glu Ala Leu Pro Tyr Arg Met Ala Asp Gly Gln Trp 
        115                 120                 125             


His Lys Val Ala Leu Ser Val Ser Ala Ser His Leu Leu Leu His Val 
    130                 135                 140                 


Asp Cys Asn Arg Ile Tyr Glu Arg Val Ile Asp Pro Pro Asp Thr Asn 
145                 150                 155                 160 


Leu Pro Pro Gly Ile Asn Leu Trp Leu Gly Gln Arg Asn Gln Lys His 
                165                 170                 175     


Gly Leu Phe Lys Gly Ile Ile Gln Asp Gly Lys Ile Ile Phe Met Pro 
            180                 185                 190         


Asn Gly Tyr Ile Thr Gln Cys Pro Asn Leu Asn His Thr Cys Pro Thr 
        195                 200                 205             


Cys Ser Asp Phe Leu Ser Leu Val Gln Gly Ile Met Asp Leu Gln Glu 
    210                 215                 220                 


Leu Leu Ala Lys Met Thr Ala Lys Leu Asn Tyr Ala Glu Thr Arg Leu 
225                 230                 235                 240 


Ser Gln Leu Glu Asn Cys His Cys Glu Lys Thr Cys Gln Val Ser Gly 
                245                 250                 255     


Leu Leu Tyr Arg Asp Gln Asp Ser Trp Val Asp Gly Asp His Cys Arg 
            260                 265                 270         


Asn Cys Thr Cys Lys Ser Gly Ala Val Glu Cys Arg Arg Met Ser Cys 
        275                 280                 285             


Pro Pro Leu Asn Cys Ser Pro Asp Ser Leu Pro Val His Ile Ala Gly 
    290                 295                 300                 


Gln Cys Cys Lys Val Cys Arg Pro Lys Cys Ile Tyr Gly Gly Lys Val 
305                 310                 315                 320 


Leu Ala Glu Gly Gln Arg Ile Leu Thr Lys Ser Cys Arg Glu Cys Arg 
                325                 330                 335     


Gly Gly Val Leu Val Lys Ile Thr Glu Met Cys Pro Pro Leu Asn Cys 
            340                 345                 350         


Ser Glu Lys Asp His Ile Leu Pro Glu Asn Gln Cys Cys Arg Val Cys 
        355                 360                 365             


Arg Gly His Asn Phe Cys Ala Glu Gly Pro Lys Cys Gly Glu Asn Ser 
    370                 375                 380                 


Glu Cys Lys Asn Trp Asn Thr Lys Ala Thr Cys Glu Cys Lys Ser Gly 
385                 390                 395                 400 


Tyr Ile Ser Val Gln Gly Asp Ser Ala Tyr Cys Glu Asp Ile Asp Glu 
                405                 410                 415     


Cys Ala Ala Lys Met His Tyr Cys His Ala Asn Thr Val Cys Val Asn 
            420                 425                 430         


Leu Pro Gly Leu Tyr Arg Cys Asp Cys Val Pro Gly Tyr Ile Arg Val 
        435                 440                 445             


Asp Asp Phe Ser Cys Thr Glu His Asp Glu Cys Gly Ser Gly Gln His 
    450                 455                 460                 


Asn Cys Asp Glu Asn Ala Ile Cys Thr Asn Thr Val Gln Gly His Ser 
465                 470                 475                 480 


Cys Thr Cys Lys Pro Gly Tyr Val Gly Asn Gly Thr Ile Cys Arg Ala 
                485                 490                 495     


Phe Cys Glu Glu Gly Cys Arg Tyr Gly Gly Thr Cys Val Ala Pro Asn 
            500                 505                 510         


Lys Cys Val Cys Pro Ser Gly Phe Thr Gly Ser His Cys Glu Lys Asp 
        515                 520                 525             


Ile Asp Glu Cys Ser Glu Gly Ile Ile Glu Cys His Asn His Ser Arg 
    530                 535                 540                 


Cys Val Asn Leu Pro Gly Trp Tyr His Cys Glu Cys Arg Ser Gly Phe 
545                 550                 555                 560 


His Asp Asp Gly Thr Tyr Ser Leu Ser Gly Glu Ser Cys Ile Asp Ile 
                565                 570                 575     


Asp Glu Cys Ala Leu Arg Thr His Thr Cys Trp Asn Asp Ser Ala Cys 
            580                 585                 590         


Ile Asn Leu Ala Gly Gly Phe Asp Cys Leu Cys Pro Ser Gly Pro Ser 
        595                 600                 605             


Cys Ser 
    610 


<210>  18
<211>  610
<212>  PRT
<213>  Equus caballus


<220>
<221>  MISC_FEATURE
<223>  NELL1 fragment

<400>  18

Phe Gly Met Asp Pro Asp Leu Gln Met Asp Ile Ile Thr Glu Leu Asp 
1               5                   10                  15      


Leu Val Asn Thr Thr Leu Gly Val Thr Gln Val Ser Gly Leu His Asn 
            20                  25                  30          


Ala Ser Lys Ala Phe Leu Phe Gln Asp Val Glu Arg Glu Ile His Ala 
        35                  40                  45              


Ala Pro His Val Ser Glu Lys Leu Ile Gln Leu Phe Arg Asn Lys Ser 
    50                  55                  60                  


Glu Phe Thr Phe Leu Ala Thr Val Gln Gln Lys Pro Ser Thr Ser Gly 
65                  70                  75                  80  


Val Ile Leu Ser Ile Arg Glu Leu Glu Asn Ser Tyr Phe Glu Leu Glu 
                85                  90                  95      


Ser Ser Gly Leu Arg Asp Glu Ile Arg Tyr His Tyr Thr His Lys Gly 
            100                 105                 110         


Lys Pro Arg Thr Glu Ala Leu Pro Tyr Arg Met Ala Asp Gly Arg Trp 
        115                 120                 125             


His Lys Val Ala Leu Ser Val Ser Ala Ser His Leu Leu Leu His Ile 
    130                 135                 140                 


Asp Cys Asn Arg Ile Tyr Glu Arg Val Ile Asp Thr Pro Glu Thr Asn 
145                 150                 155                 160 


Leu Pro Pro Gly Ser Asn Leu Trp Leu Gly Gln Arg Asn Gln Lys His 
                165                 170                 175     


Gly Leu Phe Lys Gly Ile Ile Gln Asp Gly Lys Ile Ile Phe Met Pro 
            180                 185                 190         


Asn Gly Tyr Ile Thr Gln Cys Pro Asn Leu Asn Arg Thr Cys Pro Thr 
        195                 200                 205             


Cys Ser Asp Phe Leu Ser Leu Val Gln Gly Ile Met Asp Leu Gln Glu 
    210                 215                 220                 


Leu Leu Ala Lys Met Thr Ala Lys Leu Asn Tyr Ala Glu Thr Arg Leu 
225                 230                 235                 240 


Ser Gln Leu Glu Asn Cys His Cys Glu Lys Thr Cys Gln Val Ser Gly 
                245                 250                 255     


Leu Leu Tyr Arg Asp Gln Asp Ser Trp Val Asp Gly Asp His Cys Arg 
            260                 265                 270         


Asn Cys Thr Cys Lys Ser Gly Ala Val Glu Cys Arg Arg Met Ser Cys 
        275                 280                 285             


Pro Pro Leu Asn Cys Ser Pro Asp Ser Leu Pro Val His Val Ala Gly 
    290                 295                 300                 


Gln Cys Cys Lys Val Cys Arg Pro Lys Cys Ile Tyr Gly Gly Lys Val 
305                 310                 315                 320 


Leu Ala Glu Gly Gln Arg Ile Leu Thr Lys Ser Cys Arg Glu Cys Arg 
                325                 330                 335     


Gly Gly Val Leu Val Lys Ile Thr Glu Ala Cys Pro Pro Leu Asn Cys 
            340                 345                 350         


Ser Asp Lys Asp His Ile Leu Pro Glu Asn Gln Cys Cys Ser Val Cys 
        355                 360                 365             


Arg Gly His Asn Phe Cys Ala Glu Gly Pro Lys Cys Gly Glu Asn Ser 
    370                 375                 380                 


Glu Cys Lys Asn Trp Asn Thr Lys Ala Thr Cys Glu Cys Lys Asn Gly 
385                 390                 395                 400 


Tyr Ile Ser Val Gln Gly Asp Ser Ala Tyr Cys Glu Asp Ile Asp Glu 
                405                 410                 415     


Cys Ala Ala Lys Met His Tyr Cys Arg Ala Asn Thr Val Cys Val Asn 
            420                 425                 430         


Leu Pro Gly Leu Tyr Arg Cys Asp Cys Val Pro Gly Tyr Ile Arg Val 
        435                 440                 445             


Asp Asp Phe Ser Cys Thr Glu His Asp Glu Cys Gly Ser Gly Gln His 
    450                 455                 460                 


Asn Cys Asp Glu Asn Ala Ile Cys Thr Asn Thr Val Gln Gly His Ser 
465                 470                 475                 480 


Cys Thr Cys Lys Pro Gly Tyr Val Gly Asn Gly Thr Ser Cys Arg Ala 
                485                 490                 495     


Phe Cys Glu Glu Gly Cys Arg Tyr Gly Gly Thr Cys Val Ala Pro Asn 
            500                 505                 510         


Lys Cys Val Cys Pro Ser Gly Phe Thr Gly Ser His Cys Glu Lys Asp 
        515                 520                 525             


Ile Asp Glu Cys Thr Glu Gly Ile Ile Glu Cys His Asn His Ser Arg 
    530                 535                 540                 


Cys Val Asn Leu Pro Gly Trp Tyr His Cys Glu Cys Arg Ser Gly Phe 
545                 550                 555                 560 


His Asp Asp Gly Thr Tyr Ser Leu Ser Gly Glu Ser Cys Ile Asp Ile 
                565                 570                 575     


Asp Glu Cys Ala Leu Arg Thr His Thr Cys Trp Asn Asp Ser Ala Cys 
            580                 585                 590         


Ile Asn Leu Ala Gly Gly Phe Asp Cys Leu Cys Pro Ser Gly Pro Ser 
        595                 600                 605             


Cys Ser 
    610 


<210>  19
<211>  599
<212>  PRT
<213>  Bos taurus


<220>
<221>  MISC_FEATURE
<223>  NELL1

<400>  19

Met Ala Leu Cys Ser Phe Ser Val Val Gly Phe Gly Leu Asp Pro Asp 
1               5                   10                  15      


Leu Gln Leu Asp Ile Ile Thr Glu Leu Asp Leu Val Asn Thr Thr Leu 
            20                  25                  30          


Gly Val Thr Gln Val Ser Gly Leu His Asn Thr Ser Lys Ala Phe Leu 
        35                  40                  45              


Phe Gln Asp Ala Glu Arg Glu Ile His Ala Ala Pro His Val Ser Glu 
    50                  55                  60                  


Lys Leu Ile Gln Leu Phe Arg Asn Lys Ser Glu Phe Thr Phe Leu Ala 
65                  70                  75                  80  


Thr Val Gln Gln Lys Pro Ser Thr Ser Gly Val Ile Leu Ser Ile Arg 
                85                  90                  95      


Glu Leu Glu His Ser Tyr Phe Glu Leu Glu Ser Ser Gly Leu Arg Asp 
            100                 105                 110         


Glu Ile Arg Tyr His Tyr Val His Ser Gly Arg Pro Arg Thr Glu Ala 
        115                 120                 125             


Leu Pro Tyr Arg Leu Ala Asp Gly Gln Trp His Arg Val Ala Leu Ser 
    130                 135                 140                 


Val Ser Ala Ser His Leu Leu Leu His Ile Asp Cys Asn Arg Ile Tyr 
145                 150                 155                 160 


Glu Arg Val Ile Asp Pro Pro Glu Thr Asn Leu Pro Pro Gly Ser Asn 
                165                 170                 175     


Leu Trp Leu Gly Gln Arg Asn Gln Lys His Gly Leu Phe Lys Gly Ile 
            180                 185                 190         


Ile Gln Asp Gly Lys Ile Ile Phe Met Pro Asn Gly Tyr Ile Thr Gln 
        195                 200                 205             


Cys Pro Asn Leu Asn Arg Thr Cys Pro Thr Cys Ser Asp Phe Leu Ser 
    210                 215                 220                 


Leu Val Gln Gly Ile Met Asp Leu Gln Glu Leu Leu Ala Lys Met Thr 
225                 230                 235                 240 


Ala Lys Leu Asn Tyr Ala Glu Thr Arg Leu Ser Gln Leu Glu Asn Cys 
                245                 250                 255     


His Cys Glu Lys Thr Cys Gln Val Ser Gly Leu Leu Tyr Arg Asp Gln 
            260                 265                 270         


Asp Ser Trp Val Asp Gly Asp His Cys Arg Asn Cys Thr Cys Lys Ser 
        275                 280                 285             


Gly Ala Val Glu Cys Arg Arg Met Ser Cys Pro Pro Leu Asn Cys Ser 
    290                 295                 300                 


Pro Asp Ser Leu Pro Val His Ile Ala Gly Glu Cys Cys Lys Val Cys 
305                 310                 315                 320 


Arg Pro Lys Cys Ile Tyr Gly Gly Lys Val Leu Ala Glu Gly Gln Arg 
                325                 330                 335     


Ile Leu Ser Lys Ser Cys Gln Glu Cys Arg Gly Gly Val Leu Val Lys 
            340                 345                 350         


Ile Thr Glu Ala Cys Pro Leu Leu Asn Cys Ser Glu Lys Asp His Ile 
        355                 360                 365             


Leu Pro Glu Asn Gln Cys Cys Ser Val Cys Arg Gly His Asn Phe Cys 
    370                 375                 380                 


Ala Glu Gly Pro Lys Cys Gly Glu Asn Ser Glu Cys Lys Asn Trp Asn 
385                 390                 395                 400 


Thr Lys Ala Thr Cys Glu Cys Lys Asn Gly Tyr Ile Ser Val Gln Gly 
                405                 410                 415     


Asp Ser Ala Tyr Cys Glu Asp Ile Asp Glu Cys Ala Ala Lys Met His 
            420                 425                 430         


Tyr Cys His Ala Asn Thr Val Cys Val Asn Leu Pro Gly Leu Tyr Arg 
        435                 440                 445             


Cys Asp Cys Val Pro Gly Tyr Ile Arg Val Asp Asp Phe Ser Cys Thr 
    450                 455                 460                 


Glu His Asp Asp Cys Gly Ser Gly Gln His Asn Cys Asp Glu Asn Ala 
465                 470                 475                 480 


Ile Cys Thr Asn Thr Val Gln Gly His Ser Cys Thr Cys Lys Pro Gly 
                485                 490                 495     


Tyr Val Gly Asn Gly Thr Ile Cys Arg Gly Met Pro Glu Val Gly Pro 
            500                 505                 510         


Pro Arg Ala Leu Leu Asn Ser Leu Asp Leu Gly Phe Leu Ser Phe Ser 
        515                 520                 525             


Lys Glu Ala Leu Ala Val Gly Met Ile Thr Leu Glu Gly Asn Ile Val 
    530                 535                 540                 


Ala Lys Ser Phe Thr Asp Asp Glu Thr Leu Val Glu Arg Gly Arg Glu 
545                 550                 555                 560 


Lys Val Ile Ala Leu Leu Phe Ser Trp Leu His Lys Glu Lys Leu Ser 
                565                 570                 575     


Leu Glu Asn Leu Arg Asp Ile Tyr Cys Lys Ala Asn Ser Leu Val Gly 
            580                 585                 590         


Leu Asp His Leu Pro Gln Arg 
        595                 


<210>  20
<211>  269
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  interleukin-1 beta proprotein

<400>  20

Met Ala Glu Val Pro Glu Leu Ala Ser Glu Met Met Ala Tyr Tyr Ser 
1               5                   10                  15      


Gly Asn Glu Asp Asp Leu Phe Phe Glu Ala Asp Gly Pro Lys Gln Met 
            20                  25                  30          


Lys Cys Ser Phe Gln Asp Leu Asp Leu Cys Pro Leu Asp Gly Gly Ile 
        35                  40                  45              


Gln Leu Arg Ile Ser Asp His His Tyr Ser Lys Gly Phe Arg Gln Ala 
    50                  55                  60                  


Ala Ser Val Val Val Ala Met Asp Lys Leu Arg Lys Met Leu Val Pro 
65                  70                  75                  80  


Cys Pro Gln Thr Phe Gln Glu Asn Asp Leu Ser Thr Phe Phe Pro Phe 
                85                  90                  95      


Ile Phe Glu Glu Glu Pro Ile Phe Phe Asp Thr Trp Asp Asn Glu Ala 
            100                 105                 110         


Tyr Val His Asp Ala Pro Val Arg Ser Leu Asn Cys Thr Leu Arg Asp 
        115                 120                 125             


Ser Gln Gln Lys Ser Leu Val Met Ser Gly Pro Tyr Glu Leu Lys Ala 
    130                 135                 140                 


Leu His Leu Gln Gly Gln Asp Met Glu Gln Gln Val Val Phe Ser Met 
145                 150                 155                 160 


Ser Phe Val Gln Gly Glu Glu Ser Asn Asp Lys Ile Pro Val Ala Leu 
                165                 170                 175     


Gly Leu Lys Glu Lys Asn Leu Tyr Leu Ser Cys Val Leu Lys Asp Asp 
            180                 185                 190         


Lys Pro Thr Leu Gln Leu Glu Ser Val Asp Pro Lys Asn Tyr Pro Lys 
        195                 200                 205             


Lys Lys Met Glu Lys Arg Phe Val Phe Asn Lys Ile Glu Ile Asn Asn 
    210                 215                 220                 


Lys Leu Glu Phe Glu Ser Ala Gln Phe Pro Asn Trp Tyr Ile Ser Thr 
225                 230                 235                 240 


Ser Gln Ala Glu Asn Met Pro Val Phe Leu Gly Gly Thr Lys Gly Gly 
                245                 250                 255     


Gln Asp Ile Thr Asp Phe Thr Met Gln Phe Val Ser Ser 
            260                 265                 


